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https://www.readbyqxmd.com/read/29220080/high-salinity-impacts-germination-of-the-halophyte-cakile-maritima-but-primes-seeds-for-rapid-germination-upon-stress-release
#1
Ahmed Debez, Ikram Belghith, Andreas Pich, Wael Taamalli, Chedly Abdelly, Hans-Peter Braun
Seed germination recovery aptitude is an adaptive trait of overriding significance for the successful establishment and dispersal of extremophile plants in their native ecosystems. Cakile maritima is an annual halophyte frequent on Mediterranean coasts, which transiently produces transiently dormant seeds under high salinity, but that germinate fast when soil salinity is lowered by rainfall. Here, we report eco-physiological and proteomic data about (i) the effect of high salt (200 mM NaCl) on the early developmental stages (germination and seedling) and (ii) the seed germination recovery capacity of this species...
December 8, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29185524/multiscale-scenarios-for-nature-futures
#2
Isabel M D Rosa, Henrique M Pereira, Simon Ferrier, Rob Alkemade, Lilibeth A Acosta, H Resit Akcakaya, Eefje den Belder, Asghar M Fazel, Shinichiro Fujimori, Mike Harfoot, Khaled A Harhash, Paula A Harrison, Jennifer Hauck, Rob J J Hendriks, Gladys Hernández, Walter Jetz, Sylvia I Karlsson-Vinkhuyzen, HyeJin Kim, Nicholas King, Marcel T J Kok, Grygoriy O Kolomytsev, Tanya Lazarova, Paul Leadley, Carolyn J Lundquist, Jaime García Márquez, Carsten Meyer, Laetitia M Navarro, Carsten Nesshöver, Hien T Ngo, Karachepone N Ninan, Maria G Palomo, Laura M Pereira, Garry D Peterson, Ramon Pichs, Alexander Popp, Andy Purvis, Federica Ravera, Carlo Rondinini, Jyothis Sathyapalan, Aafke M Schipper, Ralf Seppelt, Josef Settele, Nadia Sitas, Detlef van Vuuren
No abstract text is available yet for this article.
October 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29165227/reflections-on-a-community-engagement-strategy-for-mass-antimalarial-drug-administration-in-cambodia
#3
Thomas J Peto, Rupam Tripura, Chan Davoeung, Chea Nguon, Sanann Nou, Chhouen Heng, Pich Kunthea, Bipin Adhikari, Renly Lim, Nicola James, Christopher Pell, Phaik Yeong Cheah
Mass drug administration (MDA) to interrupt malaria transmission requires the participation of entire communities. As part of a clinical trial in western Cambodia, four villages received MDA in 2015-2016. Before approaching study communities, a collaboration was established with the local health authorities, village leaders, and village malaria workers. Formative research guided the development of engagement strategies. In each village, a team of volunteers was formed to explain MDA to their neighbors and provide support during implementation...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29158584/ketamine-enhances-structural-plasticity-in-mouse-mesencephalic-and-human-ipsc-derived-dopaminergic-neurons-via-ampar-driven-bdnf-and-mtor-signaling
#4
L Cavalleri, E Merlo Pich, M J Millan, C Chiamulera, T Kunath, P F Spano, G Collo
Among neurobiological mechanisms underlying antidepressant properties of ketamine, structural remodeling of prefrontal and hippocampal neurons has been proposed as critical. The suggested mechanism involves downstream activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which trigger mammalian target of rapamycin (mTOR)-dependent structural plasticity via brain-derived neurotrophic factor (BDNF) and protein neo-synthesis. We evaluated whether ketamine elicits similar molecular events in dopaminergic (DA) neurons, known to be affected in mood disorders, using a novel, translational strategy that involved mouse mesencephalic and human induced pluripotent stem cells-derived DA neurons...
November 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29136215/multitaskprotdb-ii-an-update-of-a-database-of-multitasking-moonlighting-proteins
#5
Luís Franco-Serrano, Sergio Hernández, Alejandra Calvo, María A Severi, Gabriela Ferragut, JosepAntoni Pérez-Pons, Jaume Piñol, Òscar Pich, Ángel Mozo-Villarias, Isaac Amela, Enrique Querol, Juan Cedano
Multitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references. In the present update, the number of entries has been increased from 288 to 694 moonlighting proteins...
November 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29136011/ten-year-experience-with-antiretroviral-treatment-in-cambodia-trends-in-patient-characteristics-and-treatment-outcomes
#6
Phirum Lay, Sokkab An, Sunpiseth Soeung, Pich Sovannary Srey, Sopheak Thai, Lutgarde Lynen, Johan van Griensven
BACKGROUND: Although HIV disease stage at ART initiation critically determines ART outcomes, few reports have longitudinally monitored this within Asia. Using prospectively collected data from a large ART program at Sihanouk Hospital Center of Hope in Cambodia, we report on the change in patient characteristics and outcomes over a ten-year period. METHODS: We conducted a retrospective analysis including all adults (≥ 18 years old) starting ART from March 2003-March 2013 in a non-governmental hospital in Phnom Penh, Cambodia...
2017: PloS One
https://www.readbyqxmd.com/read/29099975/chylomicron-derived-fatty-acid-spillover-in-adipose-tissue-a-signature-of-metabolic-health
#7
Marie-Eve Piché, Siôn A Parry, Fredrik Karpe, Leanne Hodson
Context and Objective: Spillover of fatty acids (FAs) into the plasma non-esterified fatty acid (NEFA) pool, due to an inability of adipose tissue to accommodate sufficient fat uptake, has been suggested to be a contributing factor to insulin resistance in obesity. Using specific labelling techniques, we compared the proportion of spillover-derived NEFA across a range of adiposity. Participants and Methods: Seventy-one healthy men and women (22-64 years; BMI 20-35 kg/m2) were fed a mixed meal (40g fat) containing [U13C]palmitate to assess the contribution of chylomicron-derived spillover FAs...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29065142/safety-and-vaccine-induced-hiv-1-immune-responses-in-healthy-volunteers-following-a-late-mva-b-boost-4-years-after-the-last-immunization
#8
RANDOMIZED CONTROLLED TRIAL
Alberto C Guardo, Carmen Elena Gómez, Vicens Díaz-Brito, Judit Pich, Joan Albert Arnaiz, Beatriz Perdiguero, Juan García-Arriaza, Nuria González, Carlos O S Sorzano, Laura Jiménez, José Luis Jiménez, María Ángeles Muñoz-Fernández, José M Gatell, José Alcamí, Mariano Esteban, Juan Carlos López Bernaldo de Quirós, Felipe García, Montserrat Plana
BACKGROUND: We have previously shown that an HIV vaccine regimen including three doses of HIV-modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B) was safe and elicited moderate and durable (1 year) T-cell and antibody responses in 75% and 95% of HIV-negative volunteers (n = 24), respectively (RISVAC02 study). Here, we describe the long-term durability of vaccine-induced responses and the safety and immunogenicity of an additional MVA-B boost. METHODS: 13 volunteers from the RISVAC02 trial were recruited to receive a fourth dose of MVA-B 4 years after the last immunization...
2017: PloS One
https://www.readbyqxmd.com/read/29058358/an-investigation-of-regional-cerebral-blood-flow-and-tissue-structure-changes-after-acute-administration-of-antipsychotics-in-healthy-male-volunteers
#9
Peter C T Hawkins, Tobias C Wood, Anthony C Vernon, Alessandro Bertolino, Fabio Sambataro, Juergen Dukart, Emilio Merlo-Pich, Celine Risterucci, Hanna Silber-Baumann, Eamonn Walsh, Ndabezinhle Mazibuko, Fernando O Zelaya, Mitul A Mehta
Chronic administration of antipsychotic drugs has been linked to structural brain changes observed in patients with schizophrenia. Recent MRI studies have shown rapid changes in regional brain volume following just a single dose of these drugs. However, it is not clear if these changes represent real volume changes or are artefacts ("apparent" volume changes) due to drug-induced physiological changes, such as increased cerebral blood flow (CBF). To address this, we examined the effects of a single, clinical dose of three commonly prescribed antipsychotics on quantitative measures of T1 and regional blood flow of the healthy human brain...
October 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29053231/effects-of-common-cold-and-concomitant-administration-of-nasal-decongestant-on-the-pharmacokinetics-and-pharmacodynamics-of-nasal-glucagon-in-otherwise-healthy-participants-a-randomized-clinical-trial
#10
Cristina B Guzman, Helene Dulude, Claude Piché, Marianne Rufiange, Aziz A Sadoune, Emmanouil Rampakakis, Dolores Carballo, Myriam Triest, Michelle Xiaotian Zhang, Shuyu Zhang, Maryam Tafreshi, Eric Sicard
AIMS: Nasal glucagon (NG) is a nasally-administered glucagon powder, absorbed through the nasal mucosa, designed for treatment of severe hypoglycaemia. This study evaluated safety, pharmacokinetics (PK), and pharmacodynamics (PD) of NG in otherwise healthy participants with common colds and after recovery from cold symptoms, with and without concomitant nasal decongestant. MATERIALS AND METHODS: This was a single-centre, open-label study. Cohort 1 participants (N=18) received two NG doses: one while experiencing nasal congestion and another after recovery from cold symptoms...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29030287/inhibition-of-pain-and-pain-related-brain-activity-by-heterotopic-noxious-counter-stimulation-and-selective-attention-in-chronic-non-specific-low-back-pain
#11
Alexandra Ladouceur, Nabi Rustamov, Jean-Daniel Dubois, Jessica Tessier, Alexandre Lehmann, Martin Descarreaux, Pierre Rainville, Mathieu Piché
The aim of the present study was to assess inhibition of pain and somatosensory-evoked potentials (SEPs) by heterotopic noxious counter-stimulation (HNCS) and by selective attention in patients with chronic non-specific LBP. Seventeen patients and age/sex-matched controls were recruited (10 men, 7 women; mean age ± SD: 43.3 ± 10.4 and 42.7 ± 11.1, respectively). On average, patients with LBP reported pain duration of 7.6 ± 6.5 years, light to moderate disability (19.3 ± 5.7/100) and low clinical pain intensity (21...
October 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/29023219/predictors-of-outcome-in-patients-with-pediatric-intracerebral-hemorrhage-development-and-validation-of-a-modified-score
#12
Alexis Guédon, Thomas Blauwblomme, Grégoire Boulouis, Camille Jousset, Philippe Meyer, Manoëlle Kossorotof, Marie Bourgeois, Stéphanie Puget, Michel Zerah, Catherine Oppenheim, Jean-François Meder, Nathalie Boddaert, Francis Brunelle, Christian Sainte-Rose, Olivier Naggara
Purpose To propose and validate a modified pediatric intracerebral hemorrhage (PICH) (mPICH) score and to compare its association with functional outcome to that of the original PICH score. Materials and Methods Data from prospectively included patients were retrospectively analyzed. Consecutive patients with nontraumatic PICH who had undergone clinical follow-up were included. The study population was divided into a development cohort (2008-2012, n = 100) and a validation cohort (2013-2016, n = 43). An mPICH score was developed after variables associated with poor outcome were identified at multivariate analysis (King's Outcome Scale for Childhood Head Injury score < 5a) in the development cohort...
October 12, 2017: Radiology
https://www.readbyqxmd.com/read/28991504/changes-in-complementarity-determining-regions-significantly-alter-igg-binding-to-the-neonatal-fc-receptor-fcrn-and-pharmacokinetics
#13
Nicole M Piche-Nicholas, Lindsay B Avery, Amy C King, Mania Kavosi, Mengmeng Wang, Denise M O'Hara, Lioudmila Tchistiakova, Madan Katragadda
A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG. We have observed that PK of IgG molecules vary widely, even when they share identical Fc domains. This led us to hypothesize that domains distal from the Fc could contribute to FcRn binding and affect PK. In this study, we explored the role of these IgG domains in altering the affinity between IgG and FcRn. Using a surface plasmon resonance-based assay developed to examine the steady-state binding affinity (KD) of IgG molecules to FcRn, we dissected the contributions of IgG domains in modulating the affinity between FcRn and IgG...
October 9, 2017: MAbs
https://www.readbyqxmd.com/read/28979779/a-clinical-genetic-approach-to-assessing-cardiovascular-risk-in-patients-with-ckd
#14
Emilio Rodrigo, Sara Pich, Isaac Subirana, Gema Fernandez-Fresnedo, Paloma Barreda, Carles Ferrer-Costa, Ángel Luis M de Francisco, Eduardo Salas, Roberto Elosua, Manuel Arias
BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported that the addition of a genetic risk score (GRS) to the Framingham risk function improved its predictive capacity in the general population. The aims of this study were to evaluate the association between this GRS and coronary events in the CKD population and to determine whether the addition of the GRS to coronary risk prediction functions improves the estimation of coronary risk at the earliest possible stages of kidney disease...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28977671/a-novel-tpr-ben-domain-interaction-mediates-pich-bend3-association
#15
Ganesha P Pitchai, Manuel Kaulich, Anna H Bizard, Pablo Mesa, Qi Yao, Kata Sarlos, Werner W Streicher, Erich A Nigg, Guillermo Montoya, Ian D Hickson
PICH is a DNA translocase required for the maintenance of chromosome stability in human cells. Recent data indicate that PICH co-operates with topoisomerase IIα to suppress pathological chromosome missegregation through promoting the resolution of ultra-fine anaphase bridges (UFBs). Here, we identify the BEN domain-containing protein 3 (BEND3) as an interaction partner of PICH in human cells in mitosis. We have purified full length PICH and BEND3 and shown that they exhibit a functional biochemical interaction in vitro...
September 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28975689/inflammatory-cell-distribution-in-colon-mucosa-as-a-new-tool-for-diagnosis-of-irritable-bowel-syndrome-a-promising-pilot-study
#16
J Boyer, M-C Saint-Paul, B Dadone, S Patouraux, M-H Vivinus, D Ouvrier, J-F Michiels, T Piche, M K Tulic
BACKGROUND: Currently, there are no histological criteria to diagnose irritable bowel syndrome (IBS). Our aims were (i) to examine the distribution of inflammatory cells in the colon of healthy and IBS subjects and (ii) to find histological diagnosis criteria for IBS. METHODS: Colonic biopsies were taken from four distinct regions of the colon from 20 controls (HC) and 11 patients with IBS (4 with constipation (IBS-C) and 7 with diarrhea (IBS-D) and embedded in paraffin...
October 4, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28957727/measuring-the-impact-of-a-point-of-view-disability-simulation-on-nursing-students-empathy-using-the-comprehensive-state-empathy-scale
#17
Tracy Levett-Jones, Samuel Lapkin, Natalie Govind, Jacqueline Pich, Kerry Hoffman, Sarah Yeun-Sim Jeong, Carol Anne Norton, Danielle Noble, Lorna Maclellan, Melissa Robinson-Reilly, Naleya Everson
BACKGROUND: Although empathy is an integral component of professional practice and person-centred care, a body of research has identified that vulnerable patients groups frequently experience healthcare that is less than optimal and often lacking in empathy. AIM: The aim of this study was to examine the impact of an immersive point-of-view simulation on nursing students' empathy towards people with an Acquired Brain Injury. SETTING AND PARTICIPANTS: A convenience sample of 390 nursing students from a cohort of 488 participated in the study, giving a response rate of 80%...
December 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#18
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and influences lipoprotein metabolism. The effect of BPD-DS on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS-associated caloric restriction (CR)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28931551/emc10-endoplasmic-reticulum-membrane-protein-complex-subunit-10-is-a-bone-marrow-derived-angiogenic-growth-factor-promoting-tissue-repair-after-myocardial-infarction
#19
Marc R Reboll, Mortimer Korf-Klingebiel, Stefanie Klede, Felix Polten, Eva Brinkmann, Ines Reimann, Hans-Joachim Schönfeld, Maria Bobadilla, Jan Faix, George Kensah, Ina Gruh, Michael Klintschar, Matthias Gaestel, Hans W Niessen, Andreas Pich, Johann Bauersachs, Joseph A Gogos, Yong Wang, Kai C Wollert
BACKGROUND: Clinical trials of bone marrow cell-based therapies after acute myocardial infarction (MI) have produced mostly neutral results. Treatment with specific bone marrow cell-derived secreted proteins may provide an alternative biological approach to improving tissue repair and heart function after MI. We recently performed a bioinformatic secretome analysis in bone marrow cells from patients with acute MI and discovered a poorly characterized secreted protein, EMC10 (endoplasmic reticulum membrane protein complex subunit 10), showing activity in an angiogenic screen...
November 7, 2017: Circulation
https://www.readbyqxmd.com/read/28902071/importance-of-risk-perception-predictors-of-prep-acceptance-among-thai-msm-and-tg-women-at-a-community-based-health-service
#20
Rosalyn Plotzker, Pich Seekaew, Jureeporn Jantarapakde, Supabhorn Pengnonyang, Deondara Trachunthong, Danai Linjongrat, Surang Janyam, Thitiyanun Nakpor, Sutinee Charoenying, Stephen Mills, Ravipa Vannakit, Michael Cassell, Praphan Phanuphak, Cheewanan Lertpiriyasuwat, Nittaya Phanuphak
BACKGROUND: HIV prevalence among Thai men who have sex with men (MSM) and transgender women (TG) are 9.15% and 11.8%, respectively, compared with 1.1% in the general population. To better understand early adopters of pre-exposure prophylaxis (PrEP) in Thailand, we analyzed biobehavioral and sociodemographic characteristics of PrEP-eligible MSM and TG. SETTING: Four Thai urban community clinics between October 2015 and February 2016. METHODS: Sociodemographics, HIV risk characteristics, and PrEP knowledge and attitudes were analyzed in association with PrEP initiation among eligible Thai MSM and TG...
December 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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