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Ian Shrier, Alexendre Piché, Russell J Steele
No abstract text is available yet for this article.
April 16, 2018: British Journal of Sports Medicine
Sergi Torres-Puig, Carlos Martínez-Torró, Ignasi Granero-Moya, Enrique Querol, Jaume Piñol, Oscar Q Pich
In the human pathogen Mycoplasma genitalium, homologous recombination is under the control of σ20, an alternative sigma factor that boosts the generation of genetic and antigenic diversity in the population. Under laboratory growth conditions, σ20 activation is rare and the factors governing its intermittent activity are unknown. Two σ20-regulated genes, rrlA and rrlB, showed to be important for recombination of homologous DNA sequences in this bacterium. Herein, we demonstrate that rrlA and rrlB code for two small proteins that participate in a feed-forward loop essential for σ20 function...
April 11, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
Thierry Paquette, Hugues Leblond, Mathieu Piché
Neurological examination remains the primary clinical investigation in patients with spinal cord injury. However, neuroimaging methods such as functional magnetic resonance imaging (fMRI) are promising tools for following functional changes in the course of injury, disease and rehabilitation. However, the relationship between neuronal activity and blood flow in the spinal cord on which fMRI relies has been largely overlooked. The objective of this study was to examine neurovascular coupling in the spinal cord of decerebrated rats during electrical stimulation of the sciatic nerve with and without isoflurane anesthesia (1...
March 29, 2018: Journal of Physiological Sciences: JPS
Jacqueline Pich
Editor's note: This is a summary of a nursing care-related systematic review from the Cochrane Library. For more information, see
April 2018: American Journal of Nursing
Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H Nelson, Marcus Q Bernardini, John M S Bartlett, Dimcho Bachvarov, Walter H Gotlieb, Blake Gilks, Jessica N McAlpine, Mark W Nachtigal, Alain Piché, Peter H Watson, Barbara Vanderhyden, David G Huntsman, Diane M Provencher, Anne-Marie Mes-Masson
BACKGROUND: Ovarian carcinoma is the most lethal gynecological malignancy due to early dissemination and acquired resistance to platinum-based chemotherapy. Reliable markers that are independent and complementary to clinical parameters are needed to improve the management of patients with this disease. The Canadian Ovarian Experimental Unified Resource (COEUR) provides researchers with biological material and associated clinical data to conduct biomarker validation studies. Using standards defined by the Canadian Tissue Repository Network (CTRNet), we have previously demonstrated the quality of the biological material from this resource...
March 27, 2018: BMC Cancer
Mangmang Xu, Shihong Zhang, Jiaqi Liu, Simiao Wu, Yajun Cheng, Ming Liu
OBJECTIVES: To investigate the association of kidney function with the total burden of cerebral small vessel disease (CSVD) in primary intracerebral hemorrhage (pICH). METHODS: Cerebral magnetic resonance imaging of consecutively enrolled pICH patients was reviewed to assess for lacunes, white matter hyperintensity (WMH), cerebral microbleeds (CMBs) and enlarged perivascular spaces (EPVS). Minor refinements to the CSVD score, namely modified CSVD score 1 and 2, were made by incorporating different weightings of CSVD markers...
March 25, 2018: Current Neurovascular Research
Marie-Eve Piché, Anne-Sophie Laberge, Patrice Brassard, Benoit J Arsenault, Olivier F Bertrand, Jean-Pierre Després, Olivier Costerousse, Paul Poirier
BACKGROUND: Individuals with type 2 diabetes (T2D) are insulin resistant and have a lower exercise capacity than individuals without T2D. AIMS: We examined the effect of 1 year treatment with the insulin sensitizer peroxisome proliferator-activated receptor (PPAR)-γ agonist rosiglitazone on exercise capacity and blood pressure (BP) response to exercise in men with coronary artery disease (CAD) and T2D. MATERIALS AND METHODS: One hundred and sixteen men (age: 64±7 yrs; body mass index: 30...
March 23, 2018: Diabetes, Obesity & Metabolism
Nathan E Holton, Amanda Piche, Todd R Yokley
OBJECTIVES: Assessing the strength of integration among different regions of the modern human nasal complex is important for developing a more thorough understanding of the determinants of nasal morphology. Given the morphogenetic influence of cartilage on adjacent intramembranous growth sites, the interaction between chondrocranial- versus intramembranous-derived nasal structures may have a significant influence on patterns of nasal variation. The purpose of this study is to examine integration between the chondrocranial- and intramembranous-derived regions of the nasal complex...
March 22, 2018: American Journal of Physical Anthropology
Xueling Song, Liying Yan, Cuiling Lu, Chunyu Zhang, Fuli Zhu, Jingjing Yang, Hongyan Jing, Yang Zhang, Jie Qiao, Hongyan Guo
Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors, 16 benign ovarian epithelial tumors) and 11 normal ovarian epithelial tissues by immunohistochemistry. The results demonstrated widespread expression of Hh pathway molecules in ovarian tumors...
April 2018: Oncology Letters
Ginetta Collo, Laura Cavalleri, Federica Bono, Cristina Mora, Stefania Fedele, Roberto William Invernizzi, Massimo Gennarelli, Giovanna Piovani, Tilo Kunath, Mark J Millan, Emilio Merlo Pich, PierFranco Spano
The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed. Since D3R agonists are highly expressed on DA neurons in humans, we studied the effect of ropinirole and pramipexole on structural plasticity using a translational model of human-inducible pluripotent stem cells (hiPSCs)...
2018: Neural Plasticity
Marianne Goudreault, Nago Humbert, France Gauvin, Monia Marzouki, Catherine K Beaumier, Dickens St-Vil, Nelson Piché
INTRODUCTION: Pediatric surgeons are often involved in the management of severely or terminally ill patients. However, articles addressing their specific roles in the context of palliative care are almost inexistent. We sought to characterize the involvement of pediatric surgeons caring for children near end of life. METHODS: Chart review of children who had a procedure under general anesthesia within 6months of their death over a five-year period at a tertiary children's hospital (excluding traumas and neonatology cases)...
February 9, 2018: Journal of Pediatric Surgery
Larry C Deeb, Hélène Dulude, Cristina B Guzman, Shuyu Zhang, Barry J Reiner, Claude A Piché, Sheetal Pradhan, Xiaotian Michelle Zhang
OBJECTIVE: This multicenter, open-label study was designed to evaluate real-world effectiveness and ease of use of nasal glucagon (NG) in treating moderate or severe hypoglycemic events in children and adolescents with type 1 diabetes (T1D). METHODS: Caregivers were trained to administer NG (3 mg) to the child/adolescent with T1D during spontaneous, symptomatic moderate or severe hypoglycemic events, observe treatment response (defined as awakening or returning to normal status within 30 minutes), and measure blood glucose (BG) levels every 15 minutes...
March 7, 2018: Pediatric Diabetes
Juergen Dukart, Štefan Holiga, Christopher Chatham, Peter Hawkins, Anna Forsyth, Rebecca McMillan, Jim Myers, Anne R Lingford-Hughes, David J Nutt, Emilio Merlo-Pich, Celine Risterucci, Lauren Boak, Daniel Umbricht, Scott Schobel, Thomas Liu, Mitul A Mehta, Fernando O Zelaya, Steve C Williams, Gregory Brown, Martin Paulus, Garry D Honey, Suresh Muthukumaraswamy, Joerg Hipp, Alessandro Bertolino, Fabio Sambataro
Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter systems remains unclear. We address this question by probing cerebral blood flow in healthy volunteers using seven established drugs with known dopaminergic, serotonergic, glutamatergic and GABAergic mechanisms of action...
March 6, 2018: Scientific Reports
Elizabeth R Seaquist, Hélène Dulude, Xiaotian Michelle Zhang, Remi Rabasa-Lhoret, George M Tsoukas, James R Conway, Stanley John Weisnagel, Gregg Gerety, Vincent C Woo, Shuyu Zhang, Dolorès Carballo, Sheetal Pradhan, Claude A Piché, Cristina B Guzman
This multi-center, open-label, prospective, phase 3 study evaluated real-world effectiveness and ease of use of nasal glucagon (NG) in the treatment of moderate/severe hypoglycemic events (HEs) in adults with type 1 diabetes (T1D). Patients and caregivers were taught how to use NG (3 mg) to treat moderate/severe HEs, record the time taken to awaken or return to normal status, and measure blood glucose (BG) levels over time. Questionnaires were used to collect information about adverse events and ease of use of NG...
March 5, 2018: Diabetes, Obesity & Metabolism
Marinalva Cardoso Dos Santos, Thais Kroetz, Cristiana Lima Dora, Fernando Carlos Giacomelli, Tiago Elias Allievi Frizon, Claus Tröger Pich, Luciano da Silva Pinto, Amanda Sigal Soares, Fabiano Severo Rodembusch, Vânia Rodrigues de Lima, Alexandre Gonçalves Dal-Bó
Investigations focused on the interactions of nanoparticles with lectins are relevant since it is well accepted that such proteins can be recognized by carbohydrates as parts of cell membranes. This can ultimately enhance the cellular uptake of the produced assemblies. In this framework, the physical interactions of phosphatidylcholine (PC) liposomes and the Bauhinia variegate lectin (BVL) are reported here. BVL-liposome interactions were characterized by a variety of techniques to understand the influence of BVL in the structural features, thermodynamic and spectroscopic properties of the hybrid material...
February 24, 2018: Journal of Colloid and Interface Science
Zoha Deldar, Nabi Rustamov, Suzie Bois, Isabelle Blanchette, Mathieu Piché
The aim of this study was to examine whether transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) enhances pain inhibition by improving working memory (WM). Forty healthy volunteers participated in two tDCS sessions. Pain was evoked by electrical stimulation at the ankle. Participants performed an n-back task (0-back and 2-back). The experimental protocol comprised five counterbalanced conditions (0-back, 2-back, pain, 0-back with pain and 2-back with pain) that were performed twice (pre-tDCS baseline and during tDCS)...
February 15, 2018: Journal of Physiological Sciences: JPS
Jacqueline Pich
No abstract text is available yet for this article.
February 13, 2018: International Journal of Nursing Practice
K Herman, M E Lang, A Pich
In the present work we used microgels as colloidal containers for the loading of hydrophobic magnetic nanoparticles using the solvent exchange method. We varied systematically two parameters: (i) the crosslinking degree of microgels (1-4.5 mol% crosslinker) and (ii) loading of hydrophobic magnetite nanoparticles (d = 7 nm) in microgels (2-10 wt%). The experimental data show that the interplay between these two parameters provides efficient control over the clustering of magnetic nanoparticles in the microgel structure...
February 8, 2018: Nanoscale
Jacqueline Pich
The mission of the Cochrane Nursing Care Field (CNCF) is to improve health outcomes through increasing the use of the Cochrane Library and supporting Cochrane's role by providing an evidence base for nurses and healthcare professionals who deliver, lead or research nursing care. The CNCF produces Cochrane Corner columns, summaries of recent nursing-care-relevant Cochrane Reviews that are regularly published in collaborating nursing-related journals. Information on the processes CNCF has developed can be accessed at: cncf...
February 7, 2018: Nursing Standard
Arnaud Lardon, Jean-Daniel Dubois, Vincent Cantin, Mathieu Piché, Martin Descarreaux
OBJECTIVES: The objective of this study was to identify baseline predictors of disability and absenteeism in workers with a history of non-specific low back pain (LBP). METHODS: One hundred workers with a history of non-specific LBP participated in three evaluations (baseline, 7 and 15 months follow-up). Current and past history of LBP, clinical pain intensity, disability, absenteeism, fear-avoidance beliefs, pain catastrophizing, pain hypervigilance, work satisfaction and patient stratification based on "risk of poor clinical outcome assessment" (RPCO) were evaluated using questionnaires and interviews...
April 2018: Applied Ergonomics
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