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https://www.readbyqxmd.com/read/29030287/inhibition-of-pain-and-pain-related-brain-activity-by-heterotopic-noxious-counter-stimulation-and-selective-attention-in-chronic-non-specific-low-back-pain
#1
Alexandra Ladouceur, Nabi Rustamov, Jean-Daniel Dubois, Jessica Tessier, Alexandre Lehmann, Martin Descarreaux, Pierre Rainville, Mathieu Piché
The aim of the present study was to assess inhibition of pain and somatosensory-evoked potentials (SEP) by heterotopic noxious counter-stimulation (HNCS) and by selective attention in patients with chronic non-specific LBP. Seventeen patients and age/sex matched controls were recruited (10 men, 7 women; mean age ± SD: 43.3 ± 10.4 and 42.7 ± 11.1, respectively). On average, patients with LBP reported pain duration of 7.6 ± 6.5 years, light to moderate disability (19.3 ± 5.7/100) and low clinical pain intensity (21...
October 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/29023219/predictors-of-outcome-in-patients-with-pediatric-intracerebral-hemorrhage-development-and-validation-of-a-modified-score
#2
Alexis Guédon, Thomas Blauwblomme, Grégoire Boulouis, Camille Jousset, Philippe Meyer, Manoëlle Kossorotof, Marie Bourgeois, Stéphanie Puget, Michel Zerah, Catherine Oppenheim, Jean-François Meder, Nathalie Boddaert, Francis Brunelle, Christian Sainte-Rose, Olivier Naggara
Purpose To propose and validate a modified pediatric intracerebral hemorrhage (PICH) (mPICH) score and to compare its association with functional outcome to that of the original PICH score. Materials and Methods Data from prospectively included patients were retrospectively analyzed. Consecutive patients with nontraumatic PICH who had undergone clinical follow-up were included. The study population was divided into a development cohort (2008-2012, n = 100) and a validation cohort (2013-2016, n = 43). An mPICH score was developed after variables associated with poor outcome were identified at multivariate analysis (King's Outcome Scale for Childhood Head Injury score < 5a) in the development cohort...
October 12, 2017: Radiology
https://www.readbyqxmd.com/read/28991504/changes-in-complementarity-determining-regions-significantly-alter-igg-binding-to-the-neonatal-fc-receptor-fcrn-and-pharmacokinetics
#3
Nicole M Piche-Nicholas, Amy C King, Lindsay B Avery, Mania Kavosi, Mengmeng Wang, Denise M O'Hara, Lioudmila Tchistiakova, Madan Katragadda
A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG. We have observed that PK of IgG molecules vary widely, even when they share identical Fc domains. This led us to hypothesize that domains distal from the Fc could contribute to FcRn binding and affect PK. In this study, we explored the role of these IgG domains in altering the affinity between IgG and FcRn. Using a surface plasmon resonance-based assay developed to examine the steady-state binding affinity (KD) of IgG molecules to FcRn, we dissected the contributions of IgG domains in modulating the affinity between FcRn and IgG...
October 9, 2017: MAbs
https://www.readbyqxmd.com/read/28979779/a-clinical-genetic-approach-to-assessing-cardiovascular-risk-in-patients-with-ckd
#4
Emilio Rodrigo, Sara Pich, Isaac Subirana, Gema Fernandez-Fresnedo, Paloma Barreda, Carles Ferrer-Costa, Ángel Luis M de Francisco, Eduardo Salas, Roberto Elosua, Manuel Arias
BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported that the addition of a genetic risk score (GRS) to the Framingham risk function improved its predictive capacity in the general population. The aims of this study were to evaluate the association between this GRS and coronary events in the CKD population and to determine whether the addition of the GRS to coronary risk prediction functions improves the estimation of coronary risk at the earliest possible stages of kidney disease...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28977671/a-novel-tpr-ben-domain-interaction-mediates-pich-bend3-association
#5
Ganesha P Pitchai, Manuel Kaulich, Anna H Bizard, Pablo Mesa, Qi Yao, Kata Sarlos, Werner W Streicher, Erich A Nigg, Guillermo Montoya, Ian D Hickson
PICH is a DNA translocase required for the maintenance of chromosome stability in human cells. Recent data indicate that PICH co-operates with topoisomerase IIα to suppress pathological chromosome missegregation through promoting the resolution of ultra-fine anaphase bridges (UFBs). Here, we identify the BEN domain-containing protein 3 (BEND3) as an interaction partner of PICH in human cells in mitosis. We have purified full length PICH and BEND3 and shown that they exhibit a functional biochemical interaction in vitro...
September 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28975689/inflammatory-cell-distribution-in-colon-mucosa-as-a-new-tool-for-diagnosis-of-irritable-bowel-syndrome-a-promising-pilot-study
#6
J Boyer, M-C Saint-Paul, B Dadone, S Patouraux, M-H Vivinus, D Ouvrier, J-F Michiels, T Piche, M K Tulic
BACKGROUND: Currently, there are no histological criteria to diagnose irritable bowel syndrome (IBS). Our aims were (i) to examine the distribution of inflammatory cells in the colon of healthy and IBS subjects and (ii) to find histological diagnosis criteria for IBS. METHODS: Colonic biopsies were taken from four distinct regions of the colon from 20 controls (HC) and 11 patients with IBS (4 with constipation (IBS-C) and 7 with diarrhea (IBS-D) and embedded in paraffin...
October 4, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28957727/measuring-the-impact-of-a-point-of-view-disability-simulation-on-nursing-students-empathy-using-the-comprehensive-state-empathy-scale
#7
Tracy Levett-Jones, Samuel Lapkin, Natalie Govind, Jacqueline Pich, Kerry Hoffman, Sarah Yeun-Sim Jeong, Carol Anne Norton, Danielle Noble, Lorna Maclellan, Melissa Robinson-Reilly, Naleya Everson
BACKGROUND: Although empathy is an integral component of professional practice and person-centred care, a body of research has identified that vulnerable patients groups frequently experience healthcare that is less than optimal and often lacking in empathy. AIM: The aim of this study was to examine the impact of an immersive point-of-view simulation on nursing students' empathy towards people with an Acquired Brain Injury. SETTING AND PARTICIPANTS: A convenience sample of 390 nursing students from a cohort of 488 participated in the study, giving a response rate of 80%...
September 20, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#8
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28931551/endoplasmic-reticulum-membrane-protein-complex-subunit-10-emc10-is-a-bone-marrow-derived-angiogenic-growth-factor-promoting-tissue-repair-after-myocardial-infarction
#9
Marc R Reboll, Mortimer Korf-Klingebiel, Stefanie Klede, Felix Polten, Eva Brinkmann, Ines Reimann, Hans-Joachim Schönfeld, Maria Bobadilla, Jan Faix, George Kensah, Ina Gruh, Michael Klintschar, Matthias Gaestel, Hans W Niessen, Andreas Pich, Johann Bauersachs, Joseph A Gogos, Yong Wang, Kai C Wollert
Background -Clinical trials of bone marrow cell (BMC)-based therapies after acute myocardial infarction (MI) have produced mostly neutral results. Treatment with specific BMC-derived secreted proteins may provide an alternative biologic approach to improving tissue repair and heart function after MI. We recently performed a bioinformatic secretome analysis in BMCs from patients with acute MI and discovered a poorly characterized secreted protein, endoplasmic reticulum membrane protein complex subunit 10 (EMC10), showing activity in an angiogenic screen...
September 20, 2017: Circulation
https://www.readbyqxmd.com/read/28902071/the-importance-of-risk-perception-predictors-of-prep-acceptance-among-thai-msm-and-tg-women-at-a-community-based-health-service
#10
Rosalyn Plotzker, Pich Seekaew, Jureeporn Jantarapakde, Supabhorn Pengnonyang, Deondara Trachunthong, Danai Lingjongrat, Surang Janyam, Thitiyanun Nakpor, Sutinee Charoenying, Stephen Mills, Ravipa Vannakit, Michael Cassell, Praphan Phanuphak, Cheewanan Lertpiriyasuwat, Nittaya Phanuphak
BACKGROUND: HIV prevalence among Thai men who have sex with men (MSM) and transgender women (TG) are 9.15% and 11.8% respectively, compared to 1.1% in the general population. To better understand early adopters of Pre-Exposure Prophylaxis (PrEP) in Thailand, we analyzed bio-behavioral and socio-demographic characteristics of PrEP-eligible MSM and TG. SETTING: Four Thai urban community clinics between October 2015 and February 2016 METHODS:: Socio-demographics, HIV risk characteristics, and PrEP knowledge and attitudes, were analyzed in association with PrEP initiation among eligible Thai MSM and TG...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28792560/-epidemiology-of-depressive-and-anxiety-disorders-among-quebec-children-and-adolescents
#11
Geneviève Piché, Marilou Cournoyer, Lise Bergeron, Marie-Ève Clément, Nicole Smolla
Epidemiology of child and adolescent mental health is a relatively new discipline, particularly in the province of Quebec. Some work has however estimated the prevalence of the most common mental disorders among young people, such as anxiety and depression, as well as identified associated individual, family and socio-economic variables. This article has two objectives: to present a review of major epidemiological research findings in child psychiatry conducted in the province of Quebec and highlight the contribution of these findings for public health...
2017: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28771876/i-was-yelled-at-intimidated-and-treated-unfairly-nursing-students-experiences-of-being-bullied-in-clinical-and-academic-settings
#12
Helen Courtney-Pratt, Jacqueline Pich, Tracy Levett-Jones, Annette Moxey
AIM: To present findings from a study that explored nursing students' experiences of bullying in clinical and academic settings, the strategies used to negotiate bullying, and recommendations for empowering future students. BACKGROUND: Nursing students are identified as a group who are at particular risk of bullying. Numerous studies have examined students' experiences of bullying in clinical contexts by qualified nurses, however, there has been far less attention to the bullying that occurs in academic settings where the perpetrators are university staff and other students...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28754390/bariatric-surgery-induced-lower-angiopoietin-like-2-protein-is-associated-with-improved-cardiometabolic-profile
#13
Marie-Eve Piché, Nathalie Thorin-Trescases, Audrey Auclair, Simon Marceau, Julie Martin, Annik Fortier, Eric Thorin, Paul Poirier
BACKGROUND: Plasma angiopoietin-like 2 (Angptl2), a proinflammatory protein, has been associated with obesity and diabetes. Whether weight loss induced by bariatric surgery and associated improvement of the cardiometabolic risk profile influence circulating Angptl2 levels is unknown. We tested whether biliopancreatic diversion with duodenal switch (BPD-DS) surgery alters plasma Angptl2 concentrations. METHODS: Severely obese patients (n = 73; body mass index: 49...
August 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28749283/seroprevalence-and-molecular-characterization-of-ferlavirus-in-captive-vipers-of-costa-rica
#14
Cristina Solis, Randall Arguedas, Mario Baldi, Martha Piche, Carlos Jimenez
Ferlaviruses (FV, previously referred to as ophidian paramyxoviruses, OPMV), are enveloped viruses with a negative-strand RNA genome, affecting snakes in captivity worldwide. Infection is characterized by respiratory and nervous clinical signs and carries high mortality rates, but no specific treatment or vaccine is currently available. Costa Rica has 16 species of vipers, found in captivity in collections essential for antivenom production, reintroduction, and public education. FV circulation in these populations was previously unknown, and the risk of introducing the viruses into naïve collections or free-ranging populations exists if the virus's presence is confirmed...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749275/clinical-challenge-the-endolymphatic-system-in-the-denny-s-tree-frog-polypedates-dennysi
#15
Ashley A Pich, Carlos R Sanchez
No abstract text is available yet for this article.
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28745493/sortase-mediated-surface-functionalization-of-stimuli-responsive-microgels
#16
Elisabeth Gau, Diana M Mate, Zhi Zou, Alex Oppermann, Alexander Töpel, Felix Jakob, Dominik Wöll, Ulrich Schwaneberg, Andrij Pich
In this work we explored an enzyme-mediated method for selective and efficient decoration of aqueous microgels with biomolecules. Poly(N-vinylcaprolactam) (VCL) microgels with varied amounts of glycidyl methacrylate (GMA) as comonomer incorporated in the microgel shell were synthesized and characterized in regard to their size, swelling degree, and temperature-responsiveness in aqueous solutions. The surface of the PVCL/GMA microgel containing 5 mol % glycidyl methyacrylate was modified by grafting of a specific recognition peptide sequence (LPETG) for Sortase A from Staphylococcus aureus (Sa-SrtAΔ59)...
August 4, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28723970/barriers-and-facilitators-of-hiv-vaccine-and-prevention-study-participation-among-young-black-msm-and-transwomen-in-new-york-city
#17
Sharise Richardson, Pich Seekaew, Beryl Koblin, Tasha Vazquez, Vijay Nandi, Hong-Van Tieu
BACKGROUND: Black men who have sex with men (MSM), and Transwomen (TW) shoulder disproportionate burden of HIV. However, they are unrepresented in HIV vaccine trials. We investigated the perceptions of that factors associated with HIV vaccine trials participation among Black MSM and TW in New York. METHODS: Self-administered online questionnaires were administered to 18-29 years of NYC residents who identified as Black MSM and TW, assessing demographics, awareness and willingness to participate in HIV vaccine trials, barriers and facilitators associated with willingness, and sexual behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/28716979/blood-biomarkers-for-the-early-diagnosis-of-stroke-the-stroke-chip-study
#18
Alejandro Bustamante, Elena López-Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa García-Berrocoso, Carles Ferrer-Costa, Teresa Gasull, María Hernández-Pérez, Mónica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, Helena Quesada, Mikel Terceño, Yolanda Silva, Mar Castellanos, Moisés Garces, Silvia Reverté, Xavier Ustrell, Rafael Marés, Joan Josep Baiges, Joaquín Serena, Francisco Rubio, Eduardo Salas, Antoni Dávalos, Joan Montaner
BACKGROUND AND PURPOSE: Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. METHODS: The Stroke-Chip was a prospective, observational, multicenter study, conducted at 6 Stroke Centers in Catalonia. Consecutive patients with suspected stroke were enrolled within the first 6 hours after symptom onset, and blood samples were drawn immediately after admission...
September 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28716590/lumbar-muscle-inflammation-alters-spinally-mediated-locomotor-recovery-induced-by-training-in-a-mouse-model-of-complete-spinal-cord-injury
#19
Renaud Jeffrey-Gauthier, Mathieu Piché, Hugues Leblond
Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion recovery in a mouse model of complete SCI. Lower limb kinematics during treadmill training was assessed before and after complete SCI at T8 (2, 7, 14, 21 and 28days post-injury). Locomotor recovery was compared in 4 groups of CD1 mice: control spinal mice; spinal mice with daily locomotor training; spinal mice with lumbar muscle inflammation (Complete Freund's Adjuvant (CFA) injection); and spinal mice with locomotor training and CFA...
July 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28714796/effect-of-bariatric-surgery-on-heart-failure
#20
Marcela Rodriguez Flores, Carlos Aguilar Salinas, Marie-Eve Piché, Audrey Auclair, Paul Poirier
Obesity increases the risk of heart failure (HF), which continues to be a significant proportion of all cardiovascular diseases and affects increasingly younger populations. The cross-talk between adipose and the heart involves insulin resistance, adipokine signaling and inflammation, with the capacity of adipose tissue to mediate hemodynamic signals, promoting progressive cardiomyopathy. Areas covered: From a therapeutic perspective, there is not yet a single obesity-related pathway that when addressed, can ameliorate cardiomyopathy in obese patients and this is a matter of ongoing research...
August 2017: Expert Review of Cardiovascular Therapy
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