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Congenital syphilis

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https://www.readbyqxmd.com/read/28942420/unique-manifestations-and-risk-factors-of-jarisch-herxheimer-reaction-during-treatment-of-child-congenital-syphilis
#1
Caiying Wang, Shuxin He, Hongling Yang, Yuhuan Liu, Yang Zhao, Lin Pang
OBJECTIVES: The objective of this retrospective study was to summarise the clinical manifestations of, and to analyse the incidence and risk factors of, Jarisch-Herxheimer reaction (JHR) during the treatment of children with symptomatic congenital syphilis. METHODS: Clinical data of 60 children with clinically and laboratory diagnosed congenital syphilis, hospitalised in Beijing Ditan Hospital between January 2010 and November 2015, were collected and analysed. RESULTS: A total of 11 patients with congenital syphilis (11/60, 18...
September 23, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28929534/emerging-arboviruses-in-rio-grande-do-sul-brazil-chikungunya-and-zika-outbreaks-2014-2016
#2
Tatiana Schäffer Gregianini, Tani Ranieri, Cátia Favreto, Zenaida Marion Alves Nunes, Gabriela Luchiari Tumioto Giannini, Nara Druck Sanberg, Marilda Tereza Mar da Rosa, Ana Beatriz Gorini da Veiga
QUESTIONS INVESTIGATED: The recent emergence of arboviruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil has posed a threat to human health and to the country's economy. Outbreaks occur mainly in tropical areas; however, increasing number of cases have been observed in Rio Grande do Sul (RS), the Southernmost state; therefore, surveillance of these arboviruses is essential for public health measures. DESIGN: In this study, we analyzed 1276 samples from patients with clinically suspected arboviral diseases between 2014 and 2016...
September 20, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28923018/effects-on-preventing-mother-to-child-transmission-of-syphilis-and-associated-adverse-pregnant-outcomes-a-longitudinal-study-from-2001-to-2015-in-shanghai-china
#3
Yang Li, Liping Zhu, Li Du, Lingxiao Qu, Weili Jiang, Biao Xu
BACKGROUND: Maternal syphilis is a health threat to both the pregnant women and the children. This study aimed to delineate the longitudinal trend of maternal syphilis and burden of associated adverse pregnant outcomes (APOs) in Shanghai from 2001 to 2015; and to evaluate the effects of preventing mother-to-child transmission (PMTCT) of syphilis in Shanghai with regard to service coverage and APOs averted. METHODS: PMTCT program of syphilis has been implemented since 2001...
September 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28918883/pseudoparalysis-of-parrot-a-diagnostic-aid-in-congenital-syphilis
#4
Annelyse Araújo Pereira, Sandra Márcia Castro, Ranielly Ribeiro Venturini, Fernanda Oliveira César, Patricia Marques Fortes, Paulo Sucasas Costa
No abstract text is available yet for this article.
September 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28889773/sensitivity-of-npcr-for-four-types-of-membrane-protein-dna-and-of-two-pairs-of-primers-for-tpp47-dna-of-treponema-pallidum-in-whole-blood-of-congenital-syphilis-newborns
#5
Yafei Guan, Rong Ding, Yequn Zhou, Xiaoqin Chen, Xiaolin Miao, Ye Zhang, Dan Luo, Shudong Cui
BACKGROUND: Problems exist in congenital syphilis (CS) diagnosis and no single test can be used to diagnose CS. OBJECTIVE: To know whether there exit differences of nPCR sensitivity among four membrane protein DNA and of nPCR between two pairs of primers for Tpp47. METHODS: We collected 30 CS patients as study group, and 20 cases admitted to hospital for other reasons as control group. The blood samples from newborns were left of blood for other examination, not special for the study...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28876321/provider-adherence-to-syphilis-testing-recommendations-for-women-delivering-a-stillbirth
#6
Chirag G Patel, Jill S Huppert, Guoyu Tao
OBJECTIVE: To assess overall adherence to Centers for Disease Control and Prevention and American College of Obstetrics and Gynecology recommended guidelines for syphilis testing among women who delivered a stillbirth and compare it with other tests recommended for stillbirth evaluation. METHODS: We used MarketScan claims data with 40 million commercially insured and 8 million Medicaid enrollees annually to estimate prenatal care and follow-up testing among women who had stillbirths between January 1, 2013, and December 24, 2013...
June 16, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28845335/congenital-syphilis-masquerading-as-leukemia
#7
Tiffany Lee, Stephanie Bell, Jason Scimeme, Nizar Maraqa
As of late, the incidence of congenital syphilis in the United States is increasing. Each new case represents a failure of preventing, diagnosing, and treating syphilis in pregnant women. Pediatricians should confirm that all women have received adequate screening for and management of syphilis during pregnancy. Congenital syphilis is easily treatable but may be a diagnostic challenge with high morbidity and mortality.
July 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28837587/the-current-status-of-syphilis-prevention-and-control-in-jiangsu-province-china-a-cross-sectional-study
#8
Yuan-Fang Chen, Jian-Ping Ding, Hong-Jing Yan, Jing Lu, Ping Ding, Guo-Hong Chen, Jian-Jun Li, Xi-Ping Huan, Hai-Tao Yang, Wei-Ming Tang, Geng-Feng Fu
OBJECTIVE: To analyze the midterm evaluation data from the National Syphilis Prevention and Control Plan (2010-2020) and evaluate the current status of syphilis prevention and control in Jiangsu province, China. METHODS: We collected data via (1) field surveys conducted in 2015 and (2) data recorded in existing syphilis surveillance systems. We conducted descriptive statistical analysis to evaluate the current landscape of syphilis control initiatives and their potential effect in syphilis control...
2017: PloS One
https://www.readbyqxmd.com/read/28832755/assessment-in-the-primary-care-of-the-state-of-s%C3%A3-o-paulo-brazil-incipient-actions-in-sexual-and-reproductive-health
#9
Mariana Arantes Nasser, Maria Ines Battistella Nemes, Marta Campagnoni Andrade, Rogério Ruscitto do Prado, Elen Rose Lodeiro Castanheira
OBJECTIVE: The objective of this study is to assess performance in sexual and reproductive health of primary health care services of the Brazilian Unified Health System, in the State of São Paulo, Brazil. METHODS: An evaluative framework was built for sexual and reproductive health with the categorization of 99 indicators in three domains: sexual and reproductive health promotion (25), sexually transmitted infections/AIDS prevention and care (43), and reproductive health care (31)...
August 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28821219/early-congenital-syphilis-recognising-symptoms-of-an-increasingly-prevalent-disease
#10
Nupur U Patel, Elias Oussedik, Erin T Landis, Lindsay C Strowd
BACKGROUND: Congenital syphilis (CS) is an infectious disease resulting from transplacental transmission of Treponema pallidum spirochetes from an infected mother to fetus during pregnancy. While uncommon, CS has shown an increased incidence in Canada and the United States since 2001 and 2012, respectively. CASE REPORT: We present the case of a 5-week-old female infant with blistering rash on the palms and soles. The infant displayed decreased movement of the left upper extremity, clinically consistent with Parrot pseudoparalysis...
August 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28820706/high-prevalence-of-treponema-pallidum-infection-in-brazilian-prisoners
#11
Maisa Estopa Correa, Julio Croda, Ana Rita Coimbra Motta de Castro, Sandra Maria do Valle Leone de Oliveira, Maurício Antonio Pompilio, Ronaldo Omizolo de Souza, Júlio Henrique Ferreira de Sá Queiroz, Kesia Esther da Silva, Albert L Ko, Simone Simionatto
The number of new syphilis cases in Brazil has risen alarmingly in recent years. However, there is limited data regarding syphilis prevalence in the Brazilian prison population. To facilitate the development of effective interventions, a cross-sectional study was undertaken to determine the prevalence of Treponema pallidum infection, active syphilis, and associated risk factors among Brazilian prisoners. We administered a questionnaire to a population-based sample of prisoners from 12 prisons in Central-West Brazil and collected sera for syphilis testing, from January to December 2013...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28807019/barriers-and-facilitators-to-the-implementation-of-antenatal-syphilis-screening-and-treatment-for-the-prevention-of-congenital-syphilis-in-the-democratic-republic-of-congo-and-zambia-results-of-qualitative-formative-research
#12
Dalau Nkamba, Musaku Mwenechanya, Arlette Mavila Kilonga, Maria Luisa Cafferata, Amanda Mabel Berrueta, Agustina Mazzoni, Fernando Althabe, Ezequiel Garcia-Elorrio, Antoniette K Tshefu, Elwyn Chomba, Pierre M Buekens, Maria Belizan
BACKGROUND: The impact of untreated syphilis during pregnancy on neonatal health remains a major public health threat worldwide. Given the high prevalence of syphilis during pregnancy in Zambia and Democratic Republic of Congo (DRC), the Preventive Congenital Syphilis Trial (PCS Trial), a cluster randomized trial, was proposed to increase same-day screening and treatment of syphilis during antenatal care visits. To design an accepted and feasible intervention, we conducted a qualitative  formative research...
August 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28735562/diagnostic-and-therapeutic-knowledge-and-practices-in-the-management-of-congenital-syphilis-by-pediatricians-in-public-maternity-hospitals-in-brazil
#13
Raquel Rodrigues Dos Santos, Roberta Pereira Niquini, Francisco Inácio Bastos, Rosa Maria Soares Madeira Domingues
The study aimed to assess conformity with Brazil's standard protocol for diagnostic and therapeutic practices in the management of congenital syphilis by pediatricians in public maternity hospitals. A cross-sectional study was conducted in 2015 with 41 pediatricians working in all the public maternity hospitals in Teresina, the capital of Piauí State, Northeast Brazil, through self-completed questionnaires. The study assessed the conformity of knowledge and practices according to the Brazilian Ministry of Health protocols...
January 1, 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28730136/early-diagnosis-of-abcb11-spectrum-liver-disorders-by-next-generation-sequencing
#14
Su Jeong Lee, Jung Eun Kim, Byung-Ho Choe, An Na Seo, Han-Ik Bae, Su-Kyeong Hwang
PURPOSE: The goal of this study was the early diagnosis of ABCB11 spectrum liver disorders, especially those focused on benign recurrent intrahepatic cholestasis and progressive familial intrahepatic cholestasis. METHODS: Fifty patients presenting neonatal cholestasis were evaluated to identify underlying etiologies. Genetic analysis was performed on patients suspected to have syndromic diseases or ABCB11 spectrum liver disorders. Two families with proven ABCB11 spectrum liver disorders were subjected to genetic analyses to confirm the diagnosis and were provided genetic counseling...
June 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28718492/-hiv-and-syphilis-coinfection-in-pregnancy-and-vertical-hiv-transmission-a-study-based-on-epidemiological-surveillance-data
#15
Lisiane M W Acosta, Tonantzin Ribeiro Gonçalves, Nêmora Tregnago Barcellos
Objective: To estimate the rate of HIV and syphilis coinfection among pregnant women living in Porto Alegre, Brazil, as well as the association of coinfection with vertical HIV transmission and socioeconomic variables. Method: This analytical retrospective cross-sectional study employed data from the regular epidemiological surveillance system for the period from 2010 to 2013. Data were obtained regarding pregnant women with HIV and exposed children, syphilis in pregnancy, and congenital syphilis...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28682315/congenital-syphilis-in-neonates-with-nonreactive-nontreponemal-test-results
#16
P S Wozniak, J B Cantey, F Zeray, N K Leos, J S Sheffield, G D Wendel, P J Sánchez
OBJECTIVE: Infants whose mothers had syphilis during pregnancy were studied to determine how often exposed newborns with normal physical examinations and nonreactive nontreponemal serologic tests had abnormal laboratory or radiographic studies. STUDY DESIGN: Retrospective analysis of prospectively collected data from infants born to mothers with syphilis and had a normal examination and a nonreactive nontreponemal test. Some infants had IgM immunoblotting, PCR testing or rabbit infectivity testing (RIT) performed...
July 6, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28665076/congenital-syphilis-presenting-with-only-nephrotic-syndrome-reemergence-of-a-forgotten-disease
#17
Yun Hee Kim, Ji Ho Song, Chan Jong Kim, Eun Mi Yang
Syphilis infection has re-emerged after years of declining incidence. The prevalence of congenital syphilis (CS) has increased in Korea and other countries during the last few decades. Untreated infants develop symptoms such as rhinorrhea, anemia, jaundice, cutaneous lesions, hepatosplenomegaly, and pseudoparalysis within weeks or months. Significant renal disease is uncommon in CS, and clinical renal involvement varies from mild transient proteinuria to frank nephrosis. We report a 2-month-old infant with CS who presented with only nephrotic syndrome (NS)...
August 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28647172/infection-related-microcephaly-after-the-2015-and-2016-zika-virus-outbreaks-in-brazil-a-surveillance-based-analysis
#18
Wanderson Kleber de Oliveira, Giovanny Vinícius Araújo de França, Eduardo Hage Carmo, Bruce Bartholow Duncan, Ricardo de Souza Kuchenbecker, Maria Inês Schmidt
BACKGROUND: On Nov 11, 2015, the Brazilian Ministry of Health declared a Public Health Emergency of National Concern in response to an increased number of microcephaly cases, possibly related to previous Zika virus outbreaks. We describe the course of the dual epidemics of the Zika virus infection during pregnancy and microcephaly in Brazil up to Nov 12, 2016, the first anniversary of this declaration. METHODS: We used secondary data for Zika virus and microcephaly cases obtained through the Brazilian Ministry of Health's surveillance systems from Jan 1, 2015, to Nov 12, 2016...
June 21, 2017: Lancet
https://www.readbyqxmd.com/read/28640799/screening-for-syphilis-and-other-sexually-transmitted-infections-in-pregnant-women-guam-2014
#19
Susan Cha, Tasneem Malik, Winston E Abara, Mia S DeSimone, Bernadette Schumann, Esther Mallada, Michael Klemme, Vince Aguon, Anne Marie Santos, Thomas A Peterman, Gail Bolan, Mary L Kamb
Prenatal screening and treatment for sexually transmitted infections (STIs) can prevent adverse perinatal outcomes. In Guam, the largest of the three U.S. territories in the Pacific, primary and secondary syphilis rates among women increased 473%, from 1.1 to 6.3 per 100,000 during 2009-2013 (1). In 2013, the first congenital syphilis case after no cases since 2008 was reported (1,2). Little is known about STI screening coverage and factors associated with inadequate screening among pregnant women in Guam. This study evaluated the prevalence of screening for syphilis, human immunodeficiency virus (HIV), chlamydia, and gonorrhea, and examined correlates of inadequate screening among pregnant women in Guam...
June 23, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28626975/congenital-syphilis
#20
Megumi Iwahashi, Yoshiki Kusama
No abstract text is available yet for this article.
June 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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