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Congenital syphilis

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https://www.readbyqxmd.com/read/29787466/dactylitis-as-the-presenting-manifestation-of-congenital-syphilis-in-an-infant
#1
Ankur Kumar Jindal, Devika Laishram, Aman Gupta, Suresh Kumar Kuchana, Ankita Singh, Parul Chawla Gupta
No abstract text is available yet for this article.
May 22, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29770234/a-case-of-congenital-syphilis-presenting-with-unusual-skin-eruptions
#2
Alexander K C Leung, Kin Fon Leong, Joseph M Lam
Once believed to be a rare disease in developed countries, recent data suggest that there is a surge in incidence of congenital syphilis in many developed countries. Diagnosis of congenital syphilis can be difficult because more than two-thirds of affected infants are asymptomatic at birth, and signs of symptomatic infants may be nonspecific or subtle. On top of this, some affected infants may have atypical presentations. Familiarity with the diverse presentations is essential to diagnosis. We report a 2-week-old male infant with congenital syphilis whose cutaneous manifestations included diffuse, erythematous keratoderma with desquamation and fissures on his hands and feet, multiple linear scaly fissures at the angles of his mouth, and onychauxis of the fingernails and toenails To our knowledge, diffuse, erythematous keratoderma of the hands and feet and thick nails have not been reported previously in congenital syphilis...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29770098/infectious-and-congenital-syphilis-in-canada-2010-2015
#3
Y Choudhri, J Miller, J Sandhu, A Leon, J Aho
Background: Syphilis is the third most commonly reported notifiable sexually transmitted infection (STI) in Canada, following chlamydia and gonorrhea, respectively. Rates of this STI have been rising rapidly in Canada since 2001. Objective: To summarize trends observed in syphilis rates for 2010 to 2015 in Canada. Methods: Laboratory-confirmed cases of infectious syphilis and early congenital syphilis were reported to the Public Health Agency of Canada by all of the Canadian provinces and territories...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29768611/deaths-of-women-hospitalized-for-childbirth-and-abortion-and-of-their-concept-in-maternity-wards-of-brazilian-public-hospitals
#4
Pauline Lorena Kale, Maria Helena Prado de Mello Jorge, Sandra Costa Fonseca, Angela Maria Cascão, Kátia Silveira da Silva, Ana Cristina Reis, Mauro Tomoyuki Taniguchi
The aim of this cross-sectional hospital-based study of 7,845 pregnancies was to analyze deaths of women hospitalized for childbirth and abortion, and fetal and neonatal deaths, in public hospitals in the cities of São Paulo, Rio de Janeiro and Niteroi (RJ), Brazil, in 2011. Outcomes of the pregnancies were: one maternal death, 498 abortions, 65 fetal deaths, 44 neonatal deaths and 7,291 infant survivors. Data were collected through interviews, medical records and the women's pregnancy records, and from the Mortality Information System (SIM)...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29721241/syphilis-infection-in-an-hiv-patient-presenting-with-leukemoid-reaction-case-report-and-review-of-the-literature
#5
Athina Lioni, Markela-Pagonitsa Zorzou, Christina Kollia, Dimitrios Loulakis, Fotini Ntziora, Fotini Stergiou, Maria Boboli, Maria Chini
Leukemoid reaction (LR) is an uncommon though dreadful sign for the treating physician, as it is related to increased mortality. In the few series that have addressed its incidence and clinical significance, infectious causes count for about half of the cases of LR, the rest accounting for cancer, drugs or rarer causes. In the HIV setting, it represents an even rarer event, owing probably to the impaired granulocytic response of AIDS patients to bacterial agents. However no report exists as to the incidence of LR to the immune-restored HIV patients adequately treated with antiretroviral therapy (ART)...
March 29, 2018: Infectious Disease Reports
https://www.readbyqxmd.com/read/29627075/congenital-syphilis
#6
REVIEW
Joshua M Cooper, Pablo J Sánchez
Congenital syphilis remains a major public health problem worldwide, and its incidence is increasing in the United States. This review highlights the ongoing problem of this preventable infection, and discusses vertical transmission and clinical manifestations while providing a practical algorithm for the evaluation and management of infants born to mothers with reactive serologic tests for syphilis. Every case of congenital syphilis must be seen as a failure of our public health system to provide optimal prenatal care to pregnant women, as congenital syphilis can be prevented by early and repeated prenatal serologic screening of mothers and penicillin treatment of infected women, their sexual partners, and their newborn infants...
April 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29624562/congenital-syphilis-prevention-strategies-evidence-and-future-directions
#7
Rosalyn E Plotzker, Ryan D Murphy, Juliet E Stoltey
BACKGROUND: Congenital syphilis (CS) - the preventable transmission of Treponema pallidum from infected mother to fetus - remains a significant problem worldwide. METHODS: From July through November 2017, 239 articles relevant to CS prevention were identified via keyword searches in PubMed and Google Scholar, ancestry searches, and expert recommendation. Articles were then assessed for 1) measurement of a specified CS or adverse pregnancy outcome (APOs) and 2) geographic setting in high/upper middle income countries according to United Nations criteria...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29570589/the-re-emergence-of-congenital-syphilis-in-ohio
#8
Joshua M Cooper, Makeda Porter, José A Bazan, Lisa M Nicholson, Pablo J Sánchez
BACKGROUND: The recent occurrence of congenital syphilis in Columbus, OH raised concern for an increase in syphilis among women and infants. The objectives were to examine the rates of syphilis among men, women, and infants in Ohio from 2003 to 2016 and compare these rates to the rest of the United States (US). METHODS: This retrospective study evaluated cases of syphilis among men, women, and infants from 2003 to 2016 using data from the Ohio Department of Health (ODH) and the Centers for Disease Control and Prevention (CDC)...
March 21, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29562870/sleep-eeg-of-microcephaly-in-zika-outbreak
#9
Paulo Afonso Medeiros Kanda, Aline de Almeida Xavier Aguiar, Jose Lucivan Miranda, Alexandre Loverde Falcao, Claudia Suenia Andrade, Luigi Neves Dos Santos Reis, Ellen White R Bacelar Almeida, Yanes Brum Bello, Arthur Monfredinho, Rafael Guimaraes Kanda
Microcephaly (MC), previously considered rare, is now a health emergency of international concern because of the devastating Zika virus pandemic outbreak of 2015. The authors describe the electroencephalogram (EEG) findings in sleep EEG of epileptic children who were born with microcephaly in areas of Brazil with active Zika virus transmission between 2014 and 2017. The authors reviewed EEGs from 23 children. Nine were females (39.2%), and the age distribution varied from 4 to 48 months. MC was associated with mother positive serology to toxoplasmosis (toxo), rubella (rub), herpes, and dengue (1 case); toxo (1 case); chikungunya virus (CHIKV) (1 case); syphilis (1 case); and Zika virus (ZIKV) (10 cases)...
2018: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29560291/prevention-of-congenital-syphilis-through-antenatal-screenings-in-lusaka-zambia-a-systematic-review
#10
REVIEW
Faisal Akhtar, Sabah Rehman
Congenital syphilis is one of the preventable diseases caused by the gram-negative bacteria Treponema pallidum; yet, it imposes a serious global health and economic burden, with more than half of the cases resulting in serious adverse outcomes, including infant mortality. Mother-to-child transmission (MTCT) of syphilis is estimated at 3.6 million adjusted life years (DALYs) and around $309 million in medical costs. In 2006, an estimated 9.7 million children of age less than five years died in developing countries; almost four million were neonatal deaths...
January 16, 2018: Curēus
https://www.readbyqxmd.com/read/29555652/sixth-child-dies-from-congenital-syphilis-in-northern-australia
#11
Bianca Nogrady
No abstract text is available yet for this article.
March 19, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29543623/use-of-national-syphilis-surveillance-data-to-develop-a-congenital-syphilis-prevention-cascade-and-estimate-the-number-of-potential-congenital-syphilis-cases-averted
#12
Sarah Kidd, Virginia B Bowen, Elizabeth A Torrone, Gail Bolan
BACKGROUND: Recent increases in reported congenital syphilis have led to an urgent need to identify interventions that will have the greatest impact on congenital syphilis prevention. We sought to create a congenital syphilis prevention cascade using national syphilis surveillance data to (1) estimate the proportion of potential congenital syphilis cases averted with current prevention efforts, and (2) develop a classification framework to better describe why reported cases were not averted...
March 14, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29541782/the-history-of-congenital-syphilis-behind-the-inheritance-by-edvard-munch
#13
Antonio Perciaccante, Alessia Coralli
No abstract text is available yet for this article.
March 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29538279/congenital-and-heterosexual-syphilis-still-part-of-the-problem
#14
Elizabeth A Torrone, William C Miller
No abstract text is available yet for this article.
March 13, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29528993/biomedical-research-priorities-for-modern-syphilis-clinical-management-diagnosis-and-vaccines-overview-and-commentary-for-unit-1
#15
Ellen N Kersh, Sheila A Lukehart
The first session at the 2016 Syphilis Summit provided an opportunity for laboratory researchers and clinicians to comment on gaps in biomedical knowledge and technologies. Predominant themes in the presentations and discussion included the need for optimization of existing diagnostic tests, commercial availability and FDA approval of nucleic acid amplification tests for primary and secondary syphilis, development of sensitive and specific new blood tests for diagnosis of active (vs. treated) syphilis infection, clarification of the best measures for adequacy of response to treatment, continued study of complications of syphilis including neuro- and ocular syphilis, and development of a safe and effective vaccine that will protect against transmission and complications of disseminated infection (including congenital and neurosyphilis)...
March 9, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465666/characteristics-associated-with-delivery-of-an-infant-with-congenital-syphilis-and-missed-opportunities-for-prevention-california-2012-2014
#16
Hope H Biswas, Rilene A Chew Ng, Erin L Murray, Joan M Chow, Juliet E Stoltey, James P Watt, Heidi M Bauer
BACKGROUND: Congenital syphilis (CS), the transmission of Treponema pallidum from mother to fetus during pregnancy, can cause adverse birth outcomes. During 2012-2014, the CS rate in California increased >200% from 6.6 to 20.3 cases per 100,000 live births. Our objectives were to identify characteristics associated with delivering an infant with CS and missed opportunities for prevention among syphilis-infected pregnant women in California. METHODS: We linked California Department of Public Health syphilis surveillance records from women aged 15-45 years - diagnosed during March 13, 2012-December 31, 2014 - to birth records...
January 4, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465662/social-vulnerability-in-congenital-syphilis-case-mothers-qualitative-assessment-of-cases-in-indiana-2014-2016
#17
Dawne DiOrio, Karen Kroeger, Amara Ross
BACKGROUND: Congenital syphilis occurs when a pregnant woman with syphilis is not diagnosed or treated and the infection is passed in utero, causing severe infant morbidity and mortality. Congenital syphilis is easily prevented if women receive timely and adequate prenatal care. Cases of congenital syphilis are considered indicators of problems in the safety net. However, maternal social and behavioral factors can impede women's care, even when providers follow guidelines. METHODS: We reviewed case interviews and maternal records for 23 congenital syphilis cases reported to CDC from Indiana between 2014 and 2016...
January 4, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465658/pathways-to-congenital-syphilis-prevention-a-rapid-qualitative-assessment-of-barriers-and-the-public-health-response-in-caddo-parish-louisiana
#18
Karen Kroeger, Thurka Sangaramoorthy, Penny S Loosier, Rebecca Schmidt, DeAnn Gruber
BACKGROUND: Congenital syphilis (CS) disproportionately affects racial and ethnic minority women, especially in the US South. While CS is relatively easy and inexpensive to prevent through screening and treatment of pregnant women, CS cases have continued to rise and are concentrated in relatively few US counties and states. In 2010, Louisiana had the highest case rate in the country for primary, secondary, and congenital syphilis, with the highest number of CS cases in northwest Louisiana, where Shreveport is located...
January 10, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465640/context-appropriate-interventions-to-prevent-syphilis-a-narrative-review
#19
Thomas A Peterman, Susan Cha
BACKGROUND: The success of an intervention to prevent syphilis will depend on the context and the goal of the intervention. To help programs choose interventions, we reviewed major changes in context and types of interventions that may be effective. METHODS: We reviewed the literature on the changing context of syphilis in the United States and interventions to prevent syphilis, focusing on papers that included evidence of effectiveness. RESULTS: Populations acquiring syphilis are constantly changing...
February 13, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465639/multi-state-syphilis-outbreak-among-american-indians-2013-2015
#20
Virginia B Bowen, Thomas A Peterman, Dinorah L Calles, Antoine Thompson, Robert Kirkcaldy, Melanie Taylor
This article summarizes a multi-state outbreak of heterosexual syphilis, including 134 cases of syphilis in adults and adolescents and at least two cases of congenital syphilis, which occurred on an American Indian reservation in the United States during 2013-2015. In addition to providing salient details about the outbreak, the article seeks to document the case-finding and treatment activities undertaken, their relative success or failure, and the lessons learned from a coordinated, multiagency response. Of 134 adult cases of syphilis, 40% were identified by enhanced, interagency contact tracing and partner services; 26% through symptomatic testing; and 16% through screening of asymptomatic individuals as the result of an electronic medical record (EMR) screening prompt...
February 13, 2018: Sexually Transmitted Diseases
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