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https://www.readbyqxmd.com/read/29223546/sigmoidocolocystoplasty-for-neurogenic-bladder-reviewed-after-20-years
#1
Yutaka Hayashi, Emi Nishimura, Satoko Shimizu, Go Miyano, Manabu Okawada, Itsuro Nagae, Geoffrey J Lane, Kenji Katsumata, Atsuyuki Yamataka, Akihiko Tsuchida
BACKGROUND/PURPOSE: We report the current status of patients who underwent augmentation cystoplasty (AC) at least 20years previously. METHODS: Surgical history, incidence of urinary tract infection (UTI) and bladder stones, vesicoureteral reflux (VUR), urine cytology, renal function, a colon cancer tumor marker (carcinoembryonic antigen: CEA), and patient outcomes were assessed. RESULTS: Forty patients who underwent AC (mean age: 34.4years; mean follow-up time: 24...
December 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29222399/pediatric-disorders-of-orthostatic-intolerance
#2
REVIEW
Julian M Stewart, Jeffrey R Boris, Gisela Chelimsky, Phillip R Fischer, John E Fortunato, Blair P Grubb, Geoffrey L Heyer, Imad T Jarjour, Marvin S Medow, Mohammed T Numan, Paolo T Pianosi, Wolfgang Singer, Sally Tarbell, Thomas C Chelimsky
Orthostatic intolerance (OI), having difficulty tolerating an upright posture because of symptoms or signs that abate when returned to supine, is common in pediatrics. For example, ∼40% of people faint during their lives, half of whom faint during adolescence, and the peak age for first faint is 15 years. Because of this, we describe the most common forms of OI in pediatrics and distinguish between chronic and acute OI. These common forms of OI include initial orthostatic hypotension (which is a frequently seen benign condition in youngsters), true orthostatic hypotension (both neurogenic and nonneurogenic), vasovagal syncope, and postural tachycardia syndrome...
December 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/29217690/re-positioning-of-somatic-golgi-apparatus-is-essential-for-the-dendritic-establishment-of-adult-born-hippocampal-neurons
#3
Sneha Rao, Gregory W Kirschen, Joanna Szczurkowska, Adrian Di Antonio, Jia Wang, Shaoyu Ge, Maya Shelly
New dentate granule cells are continuously generated, and integrate into the pre-existing hippocampal network in the adult brain. How an adult-born neuron with initially simple spindle-like morphology develops into a complex dentate granule cell (DGC), consisting of a single apical dendrite with further branches, remains largely unknown. Here, using retroviruses to birth-date and manipulate newborn neurons, we examined initial dendritic formation, and possible underlying mechanisms. We found that GFP-expressing newborn cells began to establish a DGC-like morphology at around 7 days after birth, with a primary dendrite pointing to the molecular layer, but at this stage, with several neurites in the neurogenic zone...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29215823/validation-of-the-korean-version-of-the-scales-for-outcomes-in-parkinson-s-disease-sleep
#4
Young Hee Sung, Hee Jin Kim, Seong Beom Koh, Joong Seok Kim, Sang Jin Kim, Sang Myung Cheon, Jin Whan Cho, Yoon Joong Kim, Hyeo Il Ma, Mee Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong Min Kim, In Uk Song, Han Joon Kim, Ji Young Kim, Do Young Kwon, Jae Hyeok Lee, Jee Young Lee, Ji Seon Kim, Ji Young Yun, Jin Yong Hong, Mi Jung Kim, Jinyoung Youn, Ji Sun Kim, Eung Seok Oh, Hui Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum Yil Kwon, Hyung Eun Park, Su Yun Lee, Younsoo Kim, Hee Tae Kim, Tae Beom Ahn
BACKGROUND: Sleep problems commonly occur in patients with Parkinson's disease (PD), and are associated with a lower quality of life. The aim of the current study was to translate the English version of the Scales for Outcomes in Parkinson's Disease-Sleep (SCOPA-S) into the Korean version of SCOPA-S (K-SCOPA-S), and to evaluate its reliability and validity for use by Korean-speaking patients with PD. METHODS: In total, 136 patients with PD from 27 movement disorder centres of university-affiliated hospitals in Korea were enrolled in this study...
January 8, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29212999/-a-case-of-hyperammonemia-resulting-from-urinary-tract-infection-caused-by-urease-producing-bacteria-in-a-parkinson-s-disease-patient-with-drug-induced-urinary-retention
#5
Masahiro Yasunishi, Akihiro Koumura, Yuichi Hayashi, Shohei Nishida, Takashi Inuzuka
A 71-year-old woman with a 9-year history of Parkinson's disease was admitted to our hospital emergently because of consciousness disturbance. Her consciousness level was 200 on the Japan coma scale (JCS), and she presented with tenderness and distension of the lower abdomen. Brain computed tomography showed normal findings. Blood tests showed an increased ammonia level (209 μg/dl) with normal AST and ALT levels. We catheterized the bladder for urinary retention. Five hours after admission, the blood ammonia level decreased to 38 μg/dl, and her consciousness level improved dramatically...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29200911/dual-control-of-the-vestibulosympathetic-reflex-following-hypotension-in-rats
#6
Sang Eon Park, Yuan-Zhe Jin, Byung Rim Park
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29153234/evaluation-of-pain-syndromes-headache-and-temporomandibular-joint-disorders-in-children
#7
REVIEW
Bruce B Horswell, Jason Sheikh
After a thorough review of the history and presentation of a child's facial pain, a targeted head and neck examination is critical to the appropriate diagnosis of facial pain and temporomandibular joint disorders. It is critical to distinguish between the structural (trauma, degenerative disease, and tumor) and nonstructural (neurogenic, myogenic, and psychological) causes of pain, which will allow for incorporation of appropriate strategies of medical, psychological, dental, and surgical therapies.
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29124503/urological-dysfunction-in-synucleinopathies-epidemiology-pathophysiology-and-management
#8
REVIEW
Ryuji Sakakibara, Fuyuki Tateno, Tatsuya Yamamoto, Tomoyuki Uchiyama, Tomonori Yamanishi
OBJECTIVE: Parkinson's disease (PD) and multiple system atrophy (MSA) are major neurogenerative diseases characterized pathologically by abnormal alpha-synuclein aggregation. PD and MSA are clinically characterized by motor disorder and bladder dysfunction (mainly urinary urgency and frequency, also called overactive bladder). However, few literatures are available concerning bladder dysfunction in PD or MSA. METHOD: A systematic review. RESULTS: The bladder dysfunction in MSA is more severe than that in PD for large post-void residual or urinary retention...
November 9, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29096349/extramedullary-hematopoiesis-mimicking-mediastinal-tumor-in-a-patient-with-hereditary-spherocytosis-case-report
#9
Jae Bum Park, Song Am Lee, Yo Han Kim, Woo Surng Lee, Jae Joon Hwang
INTRODUCTION: Extramedullary hematopoiesis (EMH) is a rare disorder, defined as the appearance of hematopoietic elements outside the bone marrow or peripheral blood. The exact mechanism of this development is still unknown. We herein report a case of intrathoracic EMH, manifesting as a posterior mediastinal tumor in a patient with hereditary spherocytosis. PRESENTATION OF CASE: A 45-year-old man who presented with anemia, jaundice and abdominal pain was diagnosed with hereditary spherocytosis...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29089873/exploiting-heparan-sulfate-proteoglycans-in-human-neurogenesis-controlling-lineage-specification-and-fate
#10
REVIEW
Chieh Yu, Lyn R Griffiths, Larisa M Haupt
Unspecialized, self-renewing stem cells have extraordinary application to regenerative medicine due to their multilineage differentiation potential. Stem cell therapies through replenishing damaged or lost cells in the injured area is an attractive treatment of brain trauma and neurodegenerative neurological disorders. Several stem cell types have neurogenic potential including neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). Currently, effective use of these cells is limited by our lack of understanding and ability to direct lineage commitment and differentiation of neural lineages...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29081809/astrocytes-at-the-hub-of-the-stress-response-potential-modulation-of-neurogenesis-by-mirnas-in-astrocyte-derived-exosomes
#11
REVIEW
Alejandro Luarte, Pablo Cisternas, Ariel Caviedes, Luis Federico Batiz, Carlos Lafourcade, Ursula Wyneken, Roberto Henzi
Repetitive stress negatively affects several brain functions and neuronal networks. Moreover, adult neurogenesis is consistently impaired in chronic stress models and in associated human diseases such as unipolar depression and bipolar disorder, while it is restored by effective antidepressant treatments. The adult neurogenic niche contains neural progenitor cells in addition to amplifying progenitors, neuroblasts, immature and mature neurons, pericytes, astrocytes, and microglial cells. Because of their particular and crucial position, with their end feet enwrapping endothelial cells and their close communication with the cells of the niche, astrocytes might constitute a nodal point to bridge or transduce systemic stress signals from peripheral blood, such as glucocorticoids, to the cells involved in the neurogenic process...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29075571/quantitative-muscle-ultrasound-is-useful-for-evaluating-secondary-axonal-degeneration-in-chronic-inflammatory-demyelinating-polyneuropathy
#12
Keiichi Hokkoku, Kiyoshi Matsukura, Yudai Uchida, Midori Kuwabara, Yuichi Furukawa, Hiroshi Tsukamoto, Yuki Hatanaka, Masahiro Sonoo
INTRODUCTION: In chronic inflammatory demyelinating polyneuropathy (CIDP), exclusion of secondary axonal degeneration is challenging with conventional methods such as nerve conduction study (NCS), needle electromyography, and nerve biopsy. Increased echo intensity (EI) and decreased muscle thickness (MT) identified on muscle ultrasound (MUS) examination represent muscle denervation due to axonal degeneration in neurogenic disorders, suggesting MUS as a new tool to detect secondary axonal degeneration in patients with CIDP...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29037191/ascorbic-acid-alters-cell-fate-commitment-of-human-neural-progenitors-in-a-wnt-%C3%AE-catenin-ros-signaling-dependent-manner
#13
Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G Weiss, Daniela Panáková, Stéphanie Lucas
BACKGROUND: Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely used to expand neurogenesis from NPCs in cultures although the mechanisms of its action remain unclear. Neurogenesis from NPCs is regulated by the redox-sensitive WNT/β-catenin signaling pathway. We therefore aimed to investigate how AA interacts with this pathway and potentiates neurogenesis...
October 16, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29030680/-modern-non-cosmetic-treatment-with-botulinum-toxins
#14
REVIEW
A Straube
Botulinum toxin has been known in medical history for a long time. The first scientific investigations and thoughts on possible indications in the treatment of muscular disorders were published by the German physician and poet Justinus Kerner in 1822. The physiological effect of botulinum toxin was identified in the middle of the twentieth century and the first clinical use was reported in 1977. It was first used in ophthalmology for the correction of strabismus and some years later the therapy of blepharospasm and cervical dystonia was established...
October 13, 2017: Der Internist
https://www.readbyqxmd.com/read/29021885/fracture-dislocation-at-c6-c7-level-with-quadriplegia-after-traditional-massage-in-a-patient-with-ankylosing-spondylitis-a-case-report
#15
Kak Abilash, Qmq Mohd, Zah Ahmad, Basir Towil
Ankylosing spinal disorders (ASD) tend to result in fractures and/or dislocations after minor trauma because of the altered biomechanical properties. The relative risk of traumatic vertebral fractures in patients with ankylosing spondylitis has been estimated as three times higher than in the general population. These spine traumas, which are located at cervical level in 81% of patients with ankylosing spondylitis, are complicated by neurological lesions in 65% of patients, due to the high inherent instability of these fractures...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28991086/bowel-dysfunction-related-to-spina-bifida-keep-it-simple
#16
Charlène Brochard, Benoît Peyronnet, Anne Dariel, Hélène Ménard, Andréa Manunta, Alain Ropert, Michel Neunlist, Guillaume Bouguen, Laurent Siproudhis
BACKGROUND: Although care of urological disorders in spina bifida is well established, there is yet no agreement on a standardized approach to bowel dysfunction in this population. OBJECTIVE: The purpose of this study was to assess bowel dysfunction using validated instruments and the risk factors in adults with spina bifida. DESIGN: A multidisciplinary team prospectively collected patient data, focusing on anorectal and urological symptoms...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28984668/brain-heart-interactions-in-traumatic-brain-injury
#17
Ayman El-Menyar, Abhishek Goyal, Rifat Latifi, Hassan Al-Thani, William Frishman
The cardiovascular manifestations associated with nontraumatic head disorders are commonly known. Similar manifestations have been reported in patients with traumatic brain injury (TBI); however, the underlying mechanisms and impact on the patient's clinical outcomes are not well explored. The neurocardiac axis theory and neurogenic stunned myocardium phenomenon could partly explain the brain-heart link and interactions and can thus pave the way to a better understanding and management of TBI. Several observational retrospective studies have shown a promising role for beta-adrenergic blockers in patients with TBI in reducing the overall TBI-related mortality...
November 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28969403/the-impact-of-bladder-neck-sparing-on-urinary-continence-during-laparoscopic-radical-prostatectomy-results-from-a-high-volume-centre
#18
Ali Serdar Gozen, Yigit Akin, Mutlu Ates, Marcel Fiedler, Jens Rassweiler
OBJECTIVE: To evaluate the effects of bladder neck reconstruction techniques on early continence after laparoscopic radical prostatectomy (LRP). MATERIALS AND METHODS: This non-randomized retrospective study analyzed prospectively collected data concerning LRP. In total, 3107 patients underwent LRP between March 1999 and December 2016. Exclusion criteria were preoperative urinary incontinence, previous history of external beam radiotherapy, co-morbities which may affect urinary continence such as diabetes mellitus and/or neurogenic disorders, irregular followup, and follow-up shorter than 24 months...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28968362/ultrasonography-in-peripheral-nervous-system-diagnosis
#19
Francis O Walker
PURPOSE OF REVIEW: High-resolution ultrasound has made it possible to view most nerves and muscles in real time and to identify pathologic change in size, echo texture, and vascularity. This article focuses on the principles underlying ultrasound imaging and the application of ultrasound imaging to clinical disorders commonly seen in an electrodiagnostic laboratory. RECENT FINDINGS: Ultrasound is a sensitive and specific tool for evaluating myopathic and neurogenic muscle disease...
October 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28954467/afferent-pathway-mediated-effect-of-%C3%AE-1-adrenergic-antagonist-tamsulosin-on-the-neurogenic-bladder-after-spinal-cord-injury
#20
Jin-Hee Han, Sung-Eun Kim, Il-Gyu Ko, Jayoung Kim, Khae Hawn Kim
PURPOSE: The functions of the lower urinary tract (LUT), such as voiding and storing urine, are dependent on complex central neural networks located in the brain, spinal cord, and peripheral ganglia. Thus, the functions of the LUT are susceptible to various neurologic disorders including spinal cord injury (SCI). SCI at the cervical or thoracic levels disrupts voluntary control of voiding and the normal reflex pathways coordinating bladder and sphincter functions. In this context, it is noteworthy that α1-adrenoceptor blockers have been reported to relieve voiding symptoms and storage symptoms in elderly men with benign prostatic hyperplasia (BPH)...
September 2017: International Neurourology Journal
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