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Geriatric AND cancer

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https://www.readbyqxmd.com/read/28062326/the-impact-of-comorbidity-on-surgical-outcomes-in-older-adults-with-cancer
#1
REVIEW
Virginia Sun, Peggy S Burhenn, Lily Lai, Arti Hurria
OBJECTIVES: To provide an overview of the impact of comorbidity on surgical outcomes and postoperative geriatric events in older adults with cancer, and review key components of quality perioperative nursing care of older adults with cancer. DATA SOURCES: Journal articles, research reports, state of the science papers, position papers, and clinical guidelines from professional organizations. CONCLUSION: The high prevalence of multiple comorbidities and the associated burden of geriatric events in older adults after cancer surgery have a substantial impact on surgical outcomes, quality of life, and health care costs...
January 3, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28061830/age-nutrition-chirugie-anc-study-impact-of-a-geriatric-intervention-on-the-screening-and-management-of-undernutrition-in-elderly-patients-operated-on-for-colon-cancer-a-stepped-wedge-controlled-trial
#2
Marine Dupuis, Elisabetta Kuczewski, Laurent Villeneuve, Sylvie Bin-Dorel, Max Haine, Claire Falandry, Thomas Gilbert, Guillaume Passot, Olivier Glehen, Marc Bonnefoy
BACKGROUND: Undernutrition prior to major abdominal surgery is frequent and increases morbidity and mortality, especially in older patients. The management of undernutrition reduces postoperative complications. Nutritional management should be a priority in patient care during the preoperative period. However undernutrition is rarely detected and the guidelines are infrequently followed. Preoperative undernutrition screening should allow a better implementation of the guidelines. METHODS/DESIGN: The ANC ("Age Nutrition Chirurgie") study is an interventional, comparative, prospective, multicenter, randomized protocol based on the stepped wedge trial design...
January 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28060439/factors-associated-with-unexpected-admissions-and-mortality-among-low-functioning-older-patients-receiving-home-medical-care
#3
Hiroyuki Umegaki, Atushi Asai, Shigeru Kanda, Keiko Maeda, Takuya Shimojima, Hideki Nomura, Masafumi Kuzuya
AIM: The need for and availability of home medical care for elderly patients with limitations in terms of access to medical facilities has been increasing. We investigated the association between low function, malnutrition, dementia and multicomorbidity with patient prognosis, focusing on unexpected hospital admissions and mortality in elderly non-cancer patients receiving home care. METHODS: The study included 124 Japanese patients receiving home medical care in the form of regular visits from doctors and nurses for physical and/or mental disability...
January 6, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28057051/what-is-the-normal-value-of-the-neutrophil-to-lymphocyte-ratio
#4
Patrice Forget, Céline Khalifa, Jean-Philippe Defour, Dominique Latinne, Marie-Cécile Van Pel, Marc De Kock
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has proven its prognostic value in cardiovascular diseases, infections, inflammatory diseases and in several types of cancers. However, no cut-off has been proposed on the basis of reference values coming from healthy population. METHODS: Routine blood samples were obtained (n = 413) from workers (age: median 38, range: 21-66 years) involved in a health care prevention program, to determine means, standard deviations (SDs), 95% confidence intervals (95% CI), percentiles P2...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056465/the-impact-of-age-on-complications-survival-and-cause-of-death-following-colon-cancer-surgery
#5
Christopher T Aquina, Supriya G Mohile, Mohamedtaki A Tejani, Adan Z Becerra, Zhaomin Xu, Bradley J Hensley, Reza Arsalani-Zadeh, Francis P Boscoe, Maria J Schymura, Katia Noyes, John Rt Monson, Fergal J Fleming
BACKGROUND: Given scarce data regarding the relationship among age, complications, and survival beyond the 30-day postoperative period for oncology patients in the United States, this study identified age-related differences in complications and the rate and cause of 1-year mortality following colon cancer surgery. METHODS: The NY State Cancer Registry and Statewide Planning and Research Cooperative System identified stage I-III colon cancer resections (2004-2011)...
January 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28054112/-surgical-treatment-of-colorectal-carcinoma-in-the-elderly
#6
J Schuld, M Glanemann
Colorectal carcinoma is one of the most frequent tumor entities worldwide. The treatment of elderly and mostly polymorbid patients is an outstanding challenge in view of the demographic change with a continuously aging community. Due to the demographic changes the numbers of elderly (>65 years) and very old (≥80 years) patients are steadily increasing in surgical cohorts. This has resulted in higher morbidity and mortality rates in comparison to younger patients, with increased wound healing and cardiovascular complications but with comparable numbers of anastomotic insufficiency...
January 4, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28053513/metastatic-castration-resistant-prostate-cancer-in-very-elderly-patients-challenges-and-solutions
#7
REVIEW
Orazio Caffo, Francesca Maines, Mimma Rizzo, Stefania Kinspergher, Antonello Veccia
The treatment of elderly patients with cancer is usually viewed by clinicians as a challenge, because of the age-related decline in normal organ function and the frequent concomitant administration of multiple drugs for comorbid conditions. Clinicians therefore tend not to prescribe antineoplastic agents (mainly in the case of chemotherapy) to elderly patients, with the fear of excess toxicity leading to an unfavorable cost:benefit ratio. The cutoff age defining a cancer patient as elderly is usually 70 years, but over the last 10 years clinicians have paid more attention to functional status, as evaluated by means of a comprehensive geriatric assessment and comorbidity burden, rather than chronological age...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28052175/reasons-for-chemotherapy-refusal-or-acceptance-in-older-adults-with-cancer
#8
Naveen Gopal, Andrzej Kozikowski, Myra F Barginear, Joanna Fishbein, Renee Pekmezaris, Gisele Wolf-Klein
OBJECTIVES: The majority of Americans diagnosed as having cancer are older than 65 years. They are, however, less likely than younger patients to receive chemotherapy. Our study aimed to better understand the specific reasons for acceptance or refusal of chemotherapy in older adults with cancer. METHODS: An anonymous cross-sectional survey was distributed during a 6-month study period in a cancer center and an outpatient geriatric medicine faculty practice to patients at least 50 years old with cancer or to their family members...
January 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28051804/%C3%A2-complications-of-liver-resection-in-geriatric-patients
#9
Ivana Dedinská, Ludovít Laca, Juraj Miklusica, Blazej Palkoci, Petra Skálová, Slavomíra Lauková, Denisa Osinová, Simona Strmenová, Ján Janík, Marián Mokán
:  Introduction and aims. Liver resection is the treatment of choice for many primary and secondary liver diseases. Most studies in the elderly have reported resection of primary and secondary liver tumors, especially hepatocellular carcinoma and colorectal metastatic cancer. However, over the last two decades, hepatectomy has become safe and is now performed in the older population, implying a paradigm shift in the approach to these patients. MATERIAL AND METHODS: We retrospectively evaluated the risk factors for postoperative complications in patients over 65 years of age in comparison with those under 65 years of age after liver resection (n = 360)...
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28049616/three-decades-of-comprehensive-geriatric-assessment-evidence-coming-from-different-healthcare-settings-and-specific-clinical-conditions
#10
REVIEW
Alberto Pilotto, Alberto Cella, Andrea Pilotto, Julia Daragjati, Nicola Veronese, Clarissa Musacchio, Anna Maria Mello, Giancarlo Logroscino, Alessandro Padovani, Camilla Prete, Francesco Panza
Comprehensive geriatric assessment (CGA) is a multidisciplinary diagnostic and treatment process that identifies medical, psychosocial, and functional capabilities of older adults to develop a coordinated plan to maximize overall health with aging. Specific criteria used by CGA programs to evaluate patients include age, medical comorbidities, psychosocial problems, previous or predicted high healthcare utilization, change in living situation, and specific geriatric conditions. However, no universal criteria have been agreed upon to readily identify patients who are likely to benefit from CGA...
December 31, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28039893/chemotherapy-in-old-women-with-breast-cancer-is-age-still-a-predictor-for-under-treatment
#11
Mégane Meresse, Anne-Déborah Bouhnik, Marc-Karim Bendiane, Frédérique Retornaz, Frédérique Rousseau, Dominique Rey, Roch Giorgi
Breast cancer affects mostly older women but there are no guidelines especially devoted to adjuvant chemotherapy for this population. In this context, this study was carried out in a population-based cohort of French elderly women with breast cancer, to check adherence to the existing national guidelines according to the women's age, taking into account the evolution of the situation over time for women requiring chemotherapy. Between October 2006 and December 2008, all consecutive women included in the French Health registry for a biopsy-proven primary nonmetastatic breast cancer, aged 65-80 years at diagnosis, and living in South Eastern France, were asked to participate in a cohort study...
December 31, 2016: Breast Journal
https://www.readbyqxmd.com/read/28038782/-functional-decline-and-presence-of-symptoms-in-palliative-care-cause-or-consequence
#12
Alfredo Zamora-Mur, María Nabal-Vicuña, Aranzazu Zamora-Catevilla, Rafael García-Foncillas, Verónica Calderero-Aragón, Óscar Aubí-Catevilla, Fernando Lostalé-Latorre
INTRODUCTION: Several publications have related functional decline to the appearance of symptoms, especially psychiatric or psychological ones, such as anxiety and depression. Moreover, an initial depressive disorder or prior to functional decline usually worsens it. It was decided to investigate the relationship between the presence of functional decline, measured by a decrease in the Barthel index (BI), and the presence of symptoms. MATERIAL AND METHODS: A prospective analytical study conducted on patients referred to a Home Care Support Team (HCST)...
December 27, 2016: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28033277/a-propensity-matched-analysis-of-surgery-and-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-in-the-elderly
#13
Peng Wang, Dong Zhang, Xue-Guang Guo, Xiao-Mei Li, Le-Hui Du, Bao-Jun Sun, Xiang-Qun Fang, Ying-Hua Guo, Jun Guo, Li An, Ge-Ping Qu, Chang-Ting Liu
Elderly patients with early stage non-small cell lung cancer (NSCLC) who undergo surgical resection are at a high risk of treatment-related complications. Stereotactic body radiation therapy (SBRT) is considered an alternative treatment option with a favorable safety profile. Given that prospective comparative data on SBRT and surgical treatments are limited, we compared the 2 treatments for early stage NSCLC in the elderly.We retrospectively collected information from the database at our geriatric institution on patients with clinical stage IA/B NSCLC who were treated with surgery or SBRT...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28030446/cancer-related-cognitive-impairment-in-older-adults
#14
Andrew Edelstein, Denise Pergolizzi, Yesne Alici
PURPOSE OF REVIEW: Cancer, aging, and cognition form a complicated interface that can challenge patients, caretakers, and healthcare professionals. Although the typical aging process allows for compensatory mechanisms to help maintain daily functioning, cancer and cancer treatments can remove the fail-safes and exacerbate cognitive decline. As a result, older cancer patients can experience increased morbidity and mortality. The goal of this article is to provide additional assessment strategies, diagnostic considerations, and treatment options for providers taking care of this growing population...
December 26, 2016: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28029586/social-determinants-multimorbidity-and-patterns-of-end-of-life-care-in-older-adults-dying-from-cancer
#15
Siran M Koroukian, Nicholas K Schiltz, David F Warner, Charles W Given, Mark Schluchter, Cynthia Owusu, Nathan A Berger
OBJECTIVE: Most prior studies on aggressive end-of-life care in older patients with cancer have accounted for social determinants of health (e.g., race, income, and education), but rarely for multimoribidity (MM). In this study, we examine the association between end-of-life care and each of the social determinants of health and MM, hypothesizing that higher MM is associated with less aggressive care. METHODS: From the linked 1991-2008 Health and Retirement Study, Medicare data, and the National Death Index, we identified fee-for-service patients age ≥66years who died from cancer (n=835)...
October 28, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28024799/assessment-of-older-patients-with-cancer-edmonton-frail-scale-efs-as-a-predictor-of-adverse-outcomes-in-older-patients-undergoing-radiotherapy
#16
Lorna G Keenan, Michelle O'Brien, Tim Ryan, Mary Dunne, Orla McArdle
OBJECTIVE: In this study we evaluate the usefulness of the Edmonton Frail Scale (EFS) in predicting which older patients are at risk of developing serious toxicities during radiotherapy. MATERIALS AND METHODS: This prospective study was carried out over an 18month period. Our primary aim was to examine the Edmonton Frail Scale (EFS) as a predictor of toxicity in patients over 70years undergoing radical radiotherapy for any malignant diagnosis. RESULTS: 63 patients were recruited: 29% experienced grade 3 or greater toxicities, with very few having multiple grade 3 or greater toxicities...
December 23, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28024721/functional-and-cognitive-impairment-social-environment-frailty-and-adverse-health-outcomes-in-older-patients-with-head-and-neck-cancer-a-systematic-review
#17
REVIEW
Floor J van Deudekom, Anouk S Schimberg, Marije H Kallenberg, Marije Slingerland, Lily-Ann van der Velden, Simon P Mooijaart
OBJECTIVES: Older head and neck cancer patients are at increased risk for adverse health outcomes, but little is known about which geriatric assessment associates with poor outcome. The aim is to study the association of functional or cognitive impairment, social environment and frailty with adverse health outcomes in patients with head and neck cancer. METHODS: Four libraries were searched for studies reporting on an association of functional or cognitive impairment, social environment and frailty with adverse outcomes in head and neck cancer patients...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/27999751/responses-to-immune-checkpoint-inhibitors-in-nonagenarians
#18
Romany A N Johnpulle, Robert M Conry, Jeffrey A Sosman, Igor Puzanov, Douglas B Johnson
The incidence of melanoma continues to rise with the most rapid increase seen in the elderly population. Historically, elderly patients with advanced melanoma have had dismal clinical outcomes, in part, due to distinct tumor biology, and often ineligibility for effective therapies during their development. In addition, due to relatively few geriatric patients being accrued to clinical trials of novel immunotherapeutics, there is a paucity of data regarding their safety and efficacy. Herein, we present the clinical course of three consecutive nonagenarians (≥90 y old) with metastatic melanoma, who were treated with single-agent or combination immune checkpoint inhibitors...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27994985/mortality-in-tongue-cancer-patients-treated-by-curative-surgery-a-retrospective-cohort-study-from-cgrd
#19
Ming-Shao Tsai, Chia-Hsuan Lai, Chuan-Pin Lee, Yao-Hsu Yang, Pau-Chung Chen, Chung-Jan Kang, Geng-He Chang, Yao-Te Tsai, Chang-Hsien Lu, Chih-Yen Chien, Chi-Kuang Young, Ku-Hao Fang, Chin-Jui Liu, Re-Ming A Yeh, Wen-Cheng Chen
BACKGROUND: Our study aimed to compare the outcomes of surgical treatment of tongue cancer patients in three different age groups. METHODS: From 2004 to 2013, we retrospectively analyzed the clinical data of 1,712 patients who were treated in the four institutions constituting the Chang Gung Memorial Hospitals (CGMH). We divided and studied the patients in three age groups: Group 1, younger (<65 years); Group 2, young old (65 to <75); and Group 3, older old patients (≥75 years)...
2016: PeerJ
https://www.readbyqxmd.com/read/27993461/designing-geriatric-specific-trials-in-advanced-lung-cancer-what-who-and-how-to-study
#20
EDITORIAL
Ajeet Gajra
No abstract text is available yet for this article.
December 16, 2016: Journal of Geriatric Oncology
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