keyword
MENU ▼
Read by QxMD icon Read
search

Geriatric AND cancer

keyword
https://www.readbyqxmd.com/read/29150094/-geriatric-assessment-and-prognostic-scores-in-older-cancer-patient-additional-support-to-the-therapeutic-decision
#1
REVIEW
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29145553/tumour-boards-in-geriatric-oncology
#2
Tanya Marya Wildes, Anita O'Donovan, Giuseppe Ferdinando Colloca, Kwok-Leung Cheung
Multidisciplinary tumour board is an integral part of cancer treatment planning. Although no definite survival benefits have yet been shown by mostly observational studies, other benefits of multidisciplinary tumour board have been identified. Traditionally the multidisciplinary tumour board involves participation of treating clinicians-medical, radiation and surgical oncologists. They tend to focus on the cancer alone. There is an increasing awareness that the treatment goal for cancer in older adults is not primarily on prolonging survival, with functional preservation and quality of life being particularly important for this population...
November 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29144543/primary-thromboprophylaxis-in-individuals-without-cancer-admitted-to-a-geriatric-palliative-care-unit
#3
Adam J Gurau, Anna Berall, Jurgis Karuza, Giulia-Anna Perri
BACKGROUND/OBJECTIVES: The prevalence of individuals with advanced noncancer disease is increasing on palliative care units (PCUs), but there are no current guidelines to direct venous thromboembolism (VTE) prophylaxis decisions in these individuals. The aim of this study was to compare primary VTE prophylaxis in elderly adults with advanced noncancer diagnoses with that of those with advanced cancer on a dedicated geriatric PCU. DESIGN: Single-center retrospective chart review...
November 16, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29142786/extraordinary-clinical-benefit-to-sequential-treatment-with-targeted-therapy-and-immunotherapy-of-a-braf-v600e-and-pd-l1-positive-metastatic-lung-adenocarcinoma
#4
Shuyu D Li, Annia Martial, Alexa B Schrock, Jane J Liu
Background: The treatment algorithm for metastatic non-small cell lung cancers (NSCLCs) has been evolving rapidly due to the development of new therapeutic agents. Although guidelines are provided by National Comprehensive Cancer Network (NCCN) for treatment options according to biomarker testing results, sequentially applying the three main modalities (chemotherapy, targeted therapy and immunotherapy) remains an ad hoc practice in clinic. In light of recent FDA approval of dabrafenib and trametinib combination for metastatic NSCLCs with BRAF V600E mutation, one question arises due to insufficient clinical data is if the targeted therapy should be used before immunotherapy in patients with both BRAF V600E and PD-L1 expression...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29141942/frailty-and-the-management-of-hematologic-malignancies
#5
Gregory A Abel, Heidi D Klepin
The majority of blood cancers occur in the elderly. This fact conspires with an aging population in many countries to make rigorous assessment for frailty increasingly important for hematologic oncologists. In this review, we first define frailty and its relevance for patients with hematologic malignancy. Next, we review current data regarding the impact of domains of frailty on outcomes for blood cancers including myelodysplastic syndromes (MDS), acute leukemia, non-Hodgkin lymphomas such as chronic lymphocytic leukemia (CLL), and multiple myeloma...
November 15, 2017: Blood
https://www.readbyqxmd.com/read/29136185/cognitive-dysfunction-among-newly-diagnosed-older-patients-with-hematological-malignancy-frequency-clinical-indicators-and-predictors
#6
Sayo Aiki, Toru Okuyama, Koji Sugano, Yosuke Kubota, Fuminobu Imai, Masahiro Nishioka, Yoshinori Ito, Shinsuke Iida, Hirokazu Komatsu, Takashi Ishida, Shigeru Kusumoto, Tatsuo Akechi
Background: Medical staff often overlook or underestimate the presence or severity of cognitive dysfunction. The purpose of this study was to clarify the frequency, clinical indicators and predictors of cognitive dysfunction among newly diagnosed older patients with hematologic malignancy receiving first-line chemotherapy. Methods: Patients aged 65 years or over with a primary diagnosis of malignant lymphoma or multiple myeloma were consecutively recruited. Cognitive dysfunction was evaluated using the Mini-Mental State Examination (MMSE) twice: before starting chemotherapy (T1) and 1 month later (T2)...
November 10, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29133190/integrating-geriatric-assessment-in-the-first-line-chemotherapy-treatment-in-older-patients-with-metastatic-colorectal-cancer-results-of-a-prospective-observational-cohort-study-avaplus
#7
Lore Decoster, Cindy Kenis, Benedicte Naessens, Ghislain Houbier, Marc De Man, Guy Lambrecht, Els Monsaert, Veerle Moons, Philippe Vergauwe, Hans Prenen, Eric Van Cutsem, Hans Wildiers
OBJECTIVES: This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS: This is a Belgian multi-centre, observational cohort study. Patients≥70years old with mCRC considered suitable for first-line chemotherapy were eligible for inclusion. At baseline geriatric screening and assessment was performed...
November 10, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29129470/risk-stratification-for-surgical-outcomes-in-older-colorectal-cancer-patients-using-isar-hp-and-g8-screening-tools
#8
Esteban T D Souwer, Norbert M Verweij, Frederiek van den Bos, Esther Bastiaannet, Rob M E Slangen, Willem H Steup, Marije E Hamaker, Johanna E A Portielje
BACKGROUND: Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in older colorectal cancer patients has not been investigated. OBJECTIVE: To study the predictive value of the Geriatric 8 (G8) and Identification of Seniors at Risk for Hospitalized Patients (ISAR-HP) screening tools for adverse outcomes after elective colorectal surgery in patients older than 70years...
November 9, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29129091/issues-in-the-management-of-esophageal-cancer-and-geriatric-patients
#9
Elizabeth Won
Esophageal cancer is a disease occurring in older adults and given the aging population, the incidence of cancer in the elderly will continue to rise. However, older patients are less likely to receive treatment for their cancers based on age alone. There are limited data and guidelines for how to manage the older patient population but elderly patients can derive benefit from treatment. This review will describe issues specific to older patients with esophageal cancer with a focus on the utilization of geriatric assessment (GA) tools and how to apply geriatric principles to this cancer patients...
October 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29128297/role-of-geriatric-oncologists-in-optimizing-care-of-urological-oncology-patients
#10
REVIEW
Jean-Pierre Droz, Helen Boyle, Gilles Albrand, Nicolas Mottet, Martine Puts
CONTEXT: Urological cancers are common. Since the median age of diagnosis is 60-70 yr, many patients require geriatric as well as urological evaluation if treatment is to be tailored to individual health status including comorbidities and frailty. OBJECTIVE: To review the most important features of geriatric assessment and its expected benefits. We also consider ways in which collaboration between urologists and geriatricians and geriatric teams can benefit patient well-being...
November 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29122598/effects-of-eus-guided-intratumoral-injection-of-oligonucleotide-stnm01-on-tumor-growth-histology-and-overall-survival-in-patients-with-unresectable-pancreatic-cancer
#11
Makoto Nishimura, Miho Matsukawa, Yuko Fujii, Yoko Matsuda, Tomio Arai, Yasutoshi Ochiai, Takao Itoi, Naohisa Yahagi
BACKGROUND AND AIMS: Carbohydrate sulfotransferase 15 (CHST15) promotes tumor growth and invasion and is considered to be an emergent therapeutic target for pancreatic cancer. The aim of this study was to evaluate the safety and efficacy of EUS-guided fine-needle injection (EUS-FNI) of STNM01, the double-stranded RNA oligonucleotide that specifically represses CHST15, for use in patients with pancreatic cancer. METHODS: Six patients with unresectable pancreatic cancer, treated at Tokyo Metropolitan Geriatric Hospital, were used in this open-labeled, investigator-initiated trial...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29120933/an-overview-of-perioperative-considerations-in-elderly-patients-for-thoracic-surgery-demographics-risk-benefit-and-resource-planning
#12
Maria Castillo
PURPOSE OF REVIEW: Increasing numbers of geriatric patients will present for thoracic surgery as the population ages. The changes in physiologic reserve as well as the increase in comorbid conditions among this population must be considered in order to optimize patient care in the perioperative period. RECENT FINDINGS: For elderly patients with cancer, the risk-benefit relationship for thoracic surgery remains favorable. Consideration of comorbidities, especially chronic obstructive pulmonary disease and congestive heart failure, is important in the setting of surgical treatment, as they have implications for perioperative care as well as postoperative morbidity and mortality...
November 7, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29113668/preoperative-geriatric-nutritional-risk-index-a-predictive-and-prognostic-factor-in-patients-with-pathological-stage-i-non-small-cell-lung-cancer
#13
Fumihiro Shoji, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Gouji Toyokawa, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: Surgical outcomes of early-stage non-small cell lung cancer (NSCLC) are poor. The Geriatric Nutritional Risk Index (GNRI) is a useful parameter for evaluating nutritional status. We aimed to investigate if preoperative GNRI could be a predictive factor for pathological stage I NSCLC patients. PATIENTS AND METHODS: We retrospectively selected 141 consecutive pathological stage I NSCLC patients treated from August 2005 to August 2010. We analyzed their preoperative GNRI in univariate and multivariate Cox regression analyses for postoperative recurrence-free survival (RFS)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29090187/multimorbidity-constellations-of-conditions-across-subgroups-of-midlife-and-older-individuals-and-related-medicare-expenditures
#14
Siran M Koroukian, Nicholas K Schiltz, David F Warner, Jiayang Sun, Kurt C Stange, Charles W Given, Avi Dor
INTRODUCTION: The Department of Health and Human Services' 2010 Strategic Framework on Multiple Chronic Conditions called for the identification of common constellations of conditions in older adults. OBJECTIVES: To analyze patterns of conditions constituting multimorbidity (CCMM) and expenditures in a US representative sample of midlife and older adults (50-64 and ≥65 years of age, respectively). DESIGN: A cross-sectional study of the 2010 Health and Retirement Study (HRS; n=17,912)...
2017: J Comorb
https://www.readbyqxmd.com/read/29075972/clinical-benefits-of-single-incision-laparoscopic-surgery-for-postoperative-delirium-in-elderly-colon-cancer-patients
#15
Yujiro Nishizawa, Taishi Hata, Ichiro Takemasa, Makoto Yamasaki, Hiroshi Akasaka, Ken Sugimoto, Koki Tamai, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Chu Matsuda, Tsunekazu Mizushima, Masakazu Ikenaga, Hirofumi Yamamoto, Kohei Murata, Hiromi Rakugi, Yuichiro Doki, Masaki Mori
BACKGROUND: The number of elderly patients with colon cancer is increasing in Japan. Postoperative delirium (POD) is a major complication for elderly patients who undergo surgery, and postoperative pain is a common inducer of POD. We reported previously that single-incision laparoscopic surgery (SLS) significantly reduces postoperative pain compared to conventional laparoscopic surgery (CLS). Data are lacking about the effect of SLS on POD. This retrospective study evaluated the clinical benefits of SLS for POD in elderly patients with colon cancer...
October 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29063810/the-use-of-uhear%C3%A2-to-screen-for-hearing-loss-in-older-patients-with-cancer-as-part-of-a-comprehensive-geriatric-assessment
#16
Michelle Lycke, Philip R Debruyne, Tessa Lefebvre, Evi Martens, Lore Ketelaars, Hans Pottel, Koen Van Eygen, Sofie Derijcke, Patrick Werbrouck, Philippe Vergauwe, Karin Stellamans, Philippe Clarysse, Ingeborg Dhooge, Patricia Schofield, Tom Boterberg
OBJECTIVE: We previously validated uHear™ to screen for hearing loss in older patients with cancer without a known hearing loss, as part of a comprehensive geriatric assessment (CGA). In view of low specificity, we tested a new modified uHear™ scoring system as described by Handzel. METHODS: Patients, aged ≥70 years, were evaluated by uHear™ and conventional audiometry, which is considered the gold standard, as part of a CGA. The pass or fail screening cut-off for uHear™ was defined as having ≥2 consecutive hearing grades starting from the moderate-severe threshold zone ranging from 0...
October 24, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29059735/re-psychological-stress-in-geriatric-patients-with-genito-urinary-cancers
#17
Tomas L Griebling
No abstract text is available yet for this article.
November 2017: Journal of Urology
https://www.readbyqxmd.com/read/29055624/geriatric-assessment-and-biomarkers-in-patients-with-metastatic-breast-cancer-receiving-first-line-mono-chemotherapy-results-from-the-randomized-phase-iii-pelican-trial
#18
Friedemann Honecker, Nadia Harbeck, Claudia Schnabel, Ulrich Wedding, Dirk Waldenmaier, Steffen Saupe, Elke Jäger, Marcus Schmidt, Rolf Kreienberg, Lothar Müller, Burkhard Otremba, Julia Dorn, Mathias Warm, Salah-Eddin Al-Batran, Maike de Wit
OBJECTIVES: To determine predictive/prognostic factors for patients with metastatic breast cancer (MBC) receiving first-line monochemotherapy using biomarker analysis and geriatric assessment (GA). MATERIALS AND METHODS: Karnofsky Performance Status (KPS) and GA as clinical parameters, and prognostic inflammatory and nutritional index (PINI), and Glasgow prognostic score (GPS) as biomarkers were analyzed for association with clinical outcome within the randomized phase III PEg-LIposomal Doxorubicin vs...
October 18, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29054805/factors-predicting-adherence-to-a-tailored-dose-adjuvant-treatment-on-the-basis-of-geriatric-assessment-in-elderly-people-with-colorectal-cancer-a-prospective-study
#19
Maite Antonio, Alberto Carmona-Bayonas, Juana Saldaña, Valentí Navarro, Cristian Tebé, Ramon Salazar, Josep Maria Borràs
BACKGROUND: Selecting elderly people with colorectal cancer (CRC) for adjuvant chemotherapy is challenging. Comprehensive geriatric assessment (CGA) can help by classifying them according to their frailty profile. The supposed benefit of chemotherapy is on the basis of the rate of treatment adherence. In this study we evaluated tolerance and adherence to tailored-dose adjuvant therapy on the basis of CGA in a cohort of older patients with high-risk stage II and stage III CRC. PATIENTS AND METHODS: This was a prospective study in 193 consecutive patients aged 75 years or older...
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29050492/prevalence-of-dementia-in-a-geriatric-palliative-care-unit
#20
Amanda T Lo, Jurgis Karuza, Anna Berall, Giulia-Anna Perri
OBJECTIVES: To determine the prevalence of dementia in a palliative care unit (PCU) and to determine whether there is a difference between length of stay (LOS) and Palliative Performance Scale (PPS) score in individuals admitted with a primary diagnosis of dementia compared to individuals admitted with other noncancer and cancer diagnoses. DESIGN: Descriptive retrospective chart review. SETTING: Geriatric PCU in an academic community geriatric hospital...
January 1, 2017: American Journal of Hospice & Palliative Care
keyword
keyword
7938
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"