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https://www.readbyqxmd.com/read/28292646/follow-up-of-elderly-patients-with-urogenital-cancers-evaluation-of-geriatric-care-needs-and-related-actions
#1
Silvio Monfardini, Sara Morlino, Riccardo Valdagni, Mario Catanzaro, Ardit Tafa, Barbara Bortolato, Giovanni Petralia, Elisa Bonetto, Elisa Villa, Stefano Picozzi, Maria Cristina Locatelli, Giuseppe Galetti, Andrea Millul, Yasmin Albanese, Elisa Bianchi, Claudia Panzarino, Francesca Gerardi, Ettore Beghi
OBJECTIVES: To investigate a comprehensive geriatric assessment (CGA) with subsequent investigation of healthcare patterns in older patients with urological cancers undergoing initial surgery or radiotherapy, to verify the usefulness of the incorporation of geriatric principles in future care plans. MATERIAL AND METHODS: This is a prospective cohort study. From November 2011 to March 2015, CGA was offered to all patients aged 70+ years treated with radiotherapy or surgery at seven tertiary centers...
March 11, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28288711/marginal-zone-lymphoma-in-elderly-and-geriatric-patients
#2
REVIEW
Valentin Goede
Approximately 50% of patients with newly diagnosed marginal zone lymphoma (MZL) are of advanced age. For the three subtypes of MZL (extranodal MZL of mucosa-associated lymphoid tissue, splenic MZL, nodal MZL), the median age at diagnosis is around 65-70 years. Due to the lack of larger studies in MZL, little is known of the prevalence of comorbidity, polypharmacy, or geriatric syndromes in older patients with MZL. The impact of these concurrent conditions on the tolerability and feasibility of diagnostic or therapeutic procedures used in MZL has not been specifically investigated...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28286660/preference-of-elderly-patients-to-oral-or-intravenous-chemotherapy-in-heavily-pre-treated-recurrent-ovarian-cancer-final-results-of-a-prospective-multicenter-trial
#3
Radoslav Chekerov, Philipp Harter, Stefan Fuxius, Lars Christian Hanker, Linn Woelber, Lothar Müller, Peter Klare, Wolfgang Abenhardt, Yoana Nedkova, Isil Yalcinkaya, Georg Heinrich, Harald Sommer, Sven Mahner, Pauline Wimberger, Dominique Koensgen-Mustea, Rolf Richter, Gülten Oskay-Oezcelik, Jalid Sehouli
BACKGROUND: Palliative systemic treatment in elderly gynaecological cancer patients remains a major challenge. In recurrent ovarian cancer (ROC), treosulfan an active alkylating drug showed similar cytotoxicity whether as oral (p.o.) or intravenous (i.v.) application. The aim of this innovative trial was to evaluate the preference of elderly patients (≥65 years) for p.o. or i.v. chemotherapy focusing compliance, outcome, toxicities, and geriatric aspects as secondary endpoints. METHODS: Patients with ROC had the free choice between treosulfan i...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28285980/activities-function-and-health-related-quality-of-life-hrqol-of-older-adults-with-cancer
#4
Mackenzi Pergolotti, Allison M Deal, Grant R Williams, Ashley L Bryant, Jeannette T Bensen, Hyman B Muss, Bryce B Reeve
OBJECTIVE: This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATERIALS AND METHODS: The Health Registry/Cancer Survivorship Cohort is an institutional database designed to aid cancer survivorship research. The registry includes three measures of patient-reported HRQOL: FACT-G and PROMIS® Global measures for physical and mental health...
March 9, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28280921/the-effect-of-a-geriatric-assessment-on-treatment-decisions-for-patients-with-lung-cancer
#5
Karlijn J G Schulkes, Esteban T D Souwer, Marije E Hamaker, Henk Codrington, Simone van der Sar-van der Brugge, Jan-Willem J Lammers, Johanneke E A Portielje, Leontine J R van Elden, Frederiek van den Bos
BACKGROUND: Decision-making for older patients with lung cancer can be complex and challenging. A geriatric assessment (GA) may be helpful and is increasingly being used since 2005 when SIOG advised to incorporate this in standard work-up for the elderly with cancer. Our aim was to evaluate the value of a geriatric assessment in decision-making for patients with lung cancer. METHODS: Between January 2014 and April 2016, data on patients with lung cancer from two teaching hospitals in the Netherlands were entered in a prospective database...
March 9, 2017: Lung
https://www.readbyqxmd.com/read/28279473/issues-in-the-management-of-esophagogastric-cancer-in-geriatric-patients
#6
REVIEW
Elizabeth Won
Esophagogastric cancers predominantly affect older adults; however, older patients are less likely to be recommended for both curative and palliative treatment. Older patients have unique challenges that need to be addressed during their oncologic care. Tools such as complete geriatric assessments may help to better identify fit older adults and stratify patients for aggressive treatment strategies. This review evaluates the current knowledge and the remaining challenges in optimally managing elderly patients with esophagogastric cancers...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28273043/frailty-and-inflammatory-markers-in-older-adults-with-cancer
#7
Tomohiro F Nishijima, Allison M Deal, Grant R Williams, Emily J Guerard, Kirsten A Nyrop, Hyman B Muss
We examined the associations between frailty and inflammatory markers, in particular neutrophil lymphocyte ratio (NLR), in elderly cancer patients. We conducted cross-sectional analyses of data derived from the Carolina Seniors Registry (CSR), a database of geriatric assessments (GA) in older adults (≧65 years) with cancer. We included patients in the CSR who had a GA and complete blood count test before initiation of therapy. The primary outcome was frailty, determined using the 36-item Carolina Frailty Index (CFI)...
March 8, 2017: Aging
https://www.readbyqxmd.com/read/28258899/are-future-radiation-oncologists-equipped-with-the-knowledge-to-manage-elderly-patients-with-cancer
#8
Lucinda Morris, Niluja Thiruthaneeswaran, Margot Lehman, Gina Hasselburg, Sandra Turner
PURPOSE: To assess radiation oncology (RO) trainee knowledge, attitudes, and clinical practice relating to geriatric oncology. METHODS AND MATERIALS: A custom online survey was anonymously administered to RO trainees across Australia, New Zealand, and Singapore. The survey assessed 3 domains: (1) trainee demographics and prior training in geriatric medicine; (2) current clinical practice and attitudes regarding elderly cancer patients and radiation therapy; and (3) opinions regarding educational opportunities around geriatric oncology...
January 9, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28258889/geriatric-assessment-as-a-predictor-of-tolerance-quality-of-life-and-outcomes-in-older-patients-with-head-and-neck-cancers-and-lung-cancers-receiving-radiation-therapy
#9
Noam A VanderWalde, Allison M Deal, Elizabeth Comitz, Lori Stravers, Hyman Muss, Bryce B Reeve, Ethan Basch, Joel Tepper, Bhishamjit Chera
PURPOSE: To evaluate the association between functional status based on a geriatric assessment (GA) and outcomes of tolerance to treatment in patients with lung or head and neck cancer receiving radiation therapy (RT) or chemoradiation (CRT). METHODS AND MATERIALS: A prospective cohort study was conducted in patients aged ≥65 years with head and neck cancer or lung cancer undergoing curative intent RT or CRT. Pretreatment GA, health-related quality of life (HRQoL), and patient-reported outcomes (PRO) were obtained...
December 2, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28256432/phase-ii-study-of-dose-attenuated-bortezomib-cyclophosphamide-and-dexamethasone-vcd-lite-in-very-old-or-otherwise-toxicity-vulnerable-adults-with-newly-diagnosed-multiple-myeloma
#10
Sascha A Tuchman, Joseph O Moore, Carlos D DeCastro, Zhiguo Li, Emily Sellars, Yubin Kang, Gwynn Long, Cristina G Gasparetto
OBJECTIVES: Multiple myeloma (MM) primarily strikes older adults, but full-dose chemotherapy such as bortezomib (Velcade), cyclophosphamide and dexamethasone (VCD) is often excessively toxic to very old or frail adults and those with substantial comorbidities. We piloted dose-attenuated VCD ("VCD-Lite") in such vulnerable adults with newly diagnosed MM (NDMM). MATERIALS AND METHODS: Subjects with NDMM and a high risk of therapy-related toxicity due to factors above received bortezomib 1...
February 27, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28248432/neoadjuvant-chemotherapy-in-geriatric-head-and-neck-cancers
#11
Vijay M Patil, Vanita Noronha, Amit Joshi, Anant Ramaswamy, Sachin Dhumal, Shashikant Juvekar, Supreeta Arya, Abhishek Mahajan, Pankaj Chaturvedi, Anil D'Cruz, Atanu Bhattacharjee, Kumar Prabhash
BACKGROUND: The purpose of this study was to present our findings on the treatment completion rates and outcomes in geriatric patients with head and neck cancer treated with neoadjuvant chemotherapy followed by definitive therapy. METHODS: Geriatric patients with locally advanced head and neck cancer who received neoadjuvant chemotherapy were selected for this analysis. Overall survival (OS) and progression-free survival (PFS) were estimated. RESULTS: Forty-six of 49 patients completed neoadjuvant chemotherapy (93...
March 1, 2017: Head & Neck
https://www.readbyqxmd.com/read/28245638/impact-of-age-and-insulin-like-growth-factor-1-on-dna-damage-responses-in-uv-irradiated-human-skin
#12
REVIEW
Michael G Kemp, Dan F Spandau, Jeffrey B Travers
The growing incidence of non-melanoma skin cancer (NMSC) necessitates a thorough understanding of its primary risk factors, which include exposure to ultraviolet (UV) wavelengths of sunlight and age. Whereas UV radiation (UVR) has long been known to generate photoproducts in genomic DNA that promote genetic mutations that drive skin carcinogenesis, the mechanism by which age contributes to disease pathogenesis is less understood and has not been sufficiently studied. In this review, we highlight studies that have considered age as a variable in examining DNA damage responses in UV-irradiated skin and then discuss emerging evidence that the reduced production of insulin-like growth factor-1 (IGF-1) by senescent fibroblasts in the dermis of geriatric skin creates an environment that negatively impacts how epidermal keratinocytes respond to UVR-induced DNA damage...
February 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28241844/immune-profiles-of-elderly-breast-cancer-patients-are-altered-by-chemotherapy-and-relate-to-clinical-frailty
#13
Jithendra Kini Bailur, Graham Pawelec, Sigrid Hatse, Barbara Brouwers, Ann Smeets, Patrick Neven, Annouschka Laenen, Hans Wildiers, Christopher Shipp
BACKGROUND: Effective therapeutic management of elderly patients with cancer, on an individual basis, remains a clinical challenge. Here, we identify novel biomarkers to assess elderly patients (≥70 years of age) with breast cancer undergoing treatment with or without chemotherapy. METHODS: We performed comprehensive geriatric assessment and measured markers sensitive to alteration in ageing, including leukocyte telomere length, CMV serostatus, levels of circulating growth factors and cytokines, and immune profiling of T cell and myeloid populations in blood before and at 3 months and 12 months after initiation of therapy, using flow cytometry...
February 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28236586/impaired-mobility-depressed-mood-cognitive-impairment-and-polypharmacy-are-independently-associated-with-disability-in-older-cancer-outpatients-the-prospective-physical-frailty-in-elderly-cancer-patients-pf-ec-cohort-study
#14
Frederic Pamoukdjian, Thomas Aparicio, Laurent Zelek, Marouane Boubaya, Philippe Caillet, Veronique François, Laure de Decker, Vincent Lévy, Georges Sebbane, Elena Paillaud
OBJECTIVE: To assess the prevalence of disability and the oncologic factors associated with disability in older outpatients with cancer. MATERIALS AND METHODS: The Physical Frailty in Elderly Cancer patients (PF-EC) study (France) is a prospective bicentric observational cohort study. Two hundred and ninety outpatients with cancer were included. A cross-sectional analysis of oncologic factors and geriatric variables associated with disability that were collected using a comprehensive geriatric assessment (CGA) was conducted...
February 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28223666/-geriatric-oncology
#15
Satoko Maeno, Fumio Nagashima, Daisuke Naruge, Naohiro Okano, Kirio Kawai, Takaaki Kobayashi, Hiroshi Kitamura, Junji Furuse
The number of older adults in Japan is rising, and healthcare for older patients differs from those of younger patients.We have limited available data regarding the outcomes of cancer treatment in this population.In addition, we have few guidelines to address the evaluation and treatment of older cancer patients in Japan.The Japan Agency for Medical Research and Development(AMED)has funded clinical research focusing on elderly cancer patients.We organized the Geriatric Study Committee in Japan Clinical Oncology Group(JCOG)to develop geriatric research policy in this area...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28216387/corrigendum-to-long-term-results-of-a-concomitant-boost-radiotherapy-technique-for-elderly-patients-with-muscle-%C3%A4-nvasive-bladder-cancer-j-geriatr-oncol6-4-july-2015-316-323
#16
Emine Canyilmaz, Adnan Yoney, Lasif Serdar, Gonca Hanedan Uslu, Ozlem Aynaci, Emel Haciislamoglu, Melek Nur Yavuz
No abstract text is available yet for this article.
February 16, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28209240/geriatric-factors-and-outcomes-in-metastatic-colorectal-cancer
#17
EDITORIAL
Demetris Papamichael, Matti Aapro
No abstract text is available yet for this article.
February 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28207581/the-impact-of-an-interprofessional-oral-health-curriculum-on-trainees
#18
Oren Berkowitz, Madeline F Brisotti, Leslie Gascon, Michelle Henshaw, Laura B Kaufman
PURPOSE: Despite the prevalence of oral disease, the subject of oral health historically has been absent from medical education. We have developed an interprofessional curriculum in collaboration with our school of dentistry to teach oral health in the primary care setting to physician assistant (PA) students. The goal was to create and assess the impact of a curricular model that would be adaptable to various academic settings. METHODS: A blend of classroom, clinical skills lab, observations in the dental clinic, and observed structured clinical examinations was used to teach oral health to first-year (didactic year) PA students...
March 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28188187/electronic-rapid-fitness-assessment-a-novel-tool-for-preoperative-evaluation-of-the-geriatric-oncology-patient
#19
Armin Shahrokni, Amy Tin, Robert J Downey, Vivian Strong, Sanam Mahmoudzadeh, Manpreet K Boparai, Sincere McMillan, Andrew Vickers, Beatriz Korc-Grodzicki
Background: The American College of Surgeons and American Geriatrics Society recommend performing a geriatric assessment (GA) in the preoperative evaluation of older patients. To address this, we developed an electronic GA, the Electronic Rapid Fitness Assessment (eRFA). We reviewed the feasibility and clinical utility of the eRFA in the preoperative evaluation of geriatric patients. Methods: We performed a retrospective review of our experience using the eRFA in the preoperative assessment of geriatric patients...
February 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28181371/comparative-economic-evaluation-of-home-based-and-hospital-based-palliative-care-for-terminal-cancer-patients
#20
Koki Kato, Haruhisa Fukuda
AIM: To quantify the difference between adjusted costs for home-based palliative care and hospital-based palliative care in terminally ill cancer patients. METHODS: We carried out a case-control study of home-care patients (cases) who had died at home between January 2009 and December 2013, and hospital-care patients (controls) who had died at a hospital between April 2008 and December 2013. Data on patient characteristics were obtained from insurance claims data and medical records...
February 8, 2017: Geriatrics & Gerontology International
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