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alopecia and microneedling

Angela Hou, Brandon Cohen, Adele Haimovic, Nada Elbuluk
BACKGROUND: Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The microwounds created stimulate the release of growth factors and induce collagen production. The epidermis remains relatively intact, therefore helping to limit adverse events. The indications for microneedling therapy have grown significantly, and it is becoming a more widely used treatment in dermatology. OBJECTIVE: A comprehensive review of microneedling in human subjects and its applications in dermatology...
October 13, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Yoon Seob Kim, Kwan Ho Jeong, Jung Eun Kim, Young Jun Woo, Beom Joon Kim, Hoon Kang
BACKGROUND: Microneedle is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. No previous study showed a therapeutic effect of microneedle itself on hair growth by wounding. OBJECTIVE: The aim of this study is to investigate the effect of repeated microwound formed by microneedle on hair growth and hair growth-related genes in a murine model. METHODS: A disk microneedle roller was applied to each group of mice five times a week for three weeks...
October 2016: Annals of Dermatology
Aashim Singh, Savita Yadav
Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique. It was initially introduced for skin rejuvenation, however, now it is being used for a very wide range of indications including acne scar, acne, post-traumatic/burn scar, alopecia, skin rejuvenation, drug delivery, hyperhidrosis, stretch marks, and many more. Moreover, during the last 10 years, many new innovations have been made to the initial instrument, which was used for microneedling. This technique can be combined with other surgical techniques to provide better results...
July 2016: Indian Dermatology Online Journal
Yan Deng, Jiao Chen, Yi Zhao, Xiaohui Yan, Li Zhang, Kwongwai Choy, Jun Hu, Himanshu J Sant, Bruce K Gale, Tao Tang
Successful development of siRNA therapies has significant potential for the treatment of skin conditions (alopecia, allergic skin diseases, hyperpigmentation, psoriasis, skin cancer, pachyonychia congenital) caused by aberrant gene expression. Although hypodermic needles can be used to effectively deliver siRNA through the stratum corneum, the major challenge is that this approach is painful and the effects are restricted to the injection site. Microneedle arrays may represent a better way to deliver siRNAs across the stratum corneum...
February 18, 2016: Scientific Reports
Steve Stoll, Christian Dietlin, Claudia S Nett-Mettler
BACKGROUND: Alopecia X (hair cycle arrest) is a relatively frequent hair growth disorder in Pomeranians and several other breeds, characterized by symmetrical, noninflammatory alopecia without systemic signs. The cause and pathogenesis remain unknown. Previously reported treatments with various topical and systemic drugs have been variably successful. HYPOTHESIS: We hypothesized that superficial mechanical skin trauma applied with a microneedling device would induce long-term hair regrowth at treated sites...
October 2015: Veterinary Dermatology
Rachita Dhurat, Sukesh Mathapati
INTRODUCTION: The efficacy of conventional therapy viz. finasteride and minoxidil in androgenetic alopecia (AGA) that is based on both preventing hair loss and promoting new hair growth, varies between 30% and 60%. This has led to a large number of patients unsatisfied who demand for a better cosmetic coverage over the scalp. Microneedling has recently been reported to be promising, effective and a safe treatment modality in the treatment of AGA. This augments the response of conventional therapy...
May 2015: Indian Journal of Dermatology
Bs Chandrashekar, Vani Yepuri, Venkataram Mysore
No abstract text is available yet for this article.
January 2014: Journal of Cutaneous and Aesthetic Surgery
Rachita Dhurat, Ms Sukesh, Ganesh Avhad, Ameet Dandale, Anjali Pal, Poonam Pund
INTRODUCTION: Dermal papilla (DP) is the site of expression of various hair growth related genes. Various researches have demonstrated the underlying importance of Wnt proteins and wound growth factors in stimulating DP associated stem cells. Microneedling works by stimulation of stem cells and inducing activation of growth factors. MATERIALS AND METHODS: Hundred cases of mild to moderate (III vertex or IV) androgenetic alopecia (AGA) were recruited into 2 groups...
January 2013: International Journal of Trichology
Kwang Ho Yoo, Jin Woong Lee, Kapsok Li, Beom Joon Kim, Myeung Nam Kim
BACKGROUND: Photodynamic therapy (PDT) with aminolevulinic acid or methyl 5-aminolevulinic acid (MAL) has been tried for the treatment of alopecia areata (AA). Unfortunately, the efficacy of PDT in treating AA is still being debated, and most clinical trials have produced disappointing results, which may have been because of the lack of treatment rationale or because of drug penetration. In several clinical trials of PDT in AA, the dermatologists suspected that skin preparations, including mechanical or chemical peeling, might be incomplete for drug penetration...
May 2010: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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