Paola Bisaccia, Fabio Magarotto, Stefania D'Agostino, Arben Dedja, Silvia Barbon, Diego Guidolin, Cristina Liboni, Roberta Angioni, Giada De Lazzari, Federico Caicci, Antonella Viola, Marcin Jurga, Gabrielis Kundrotas, Dimitri Stevens, Domenico Mancuso, Elisabetta Gramegna, Bruno Seitaj, Rudra Kashyap, Beatrice De Vos, Veronica Macchi, Eugenio Baraldi, Andrea Porzionato, Raffaele De Caro, Maurizio Muraca, Michela Pozzobon
Oxidative stress and fibrosis are important stress responses that characterize bronchopulmonary dysplasia (BPD), a disease for which only a therapy but not a cure has been developed. In this work, we investigated the effects of mesenchymal stromal cells-derived extracellular vesicles (MSC-EVs) on lung and brain compartment in an animal model of hyperoxia-induced BPD. Rat pups were intratracheally injected with MSC-EVs produced by human umbilical cord-derived MSC, following the Good Manufacturing Practice-grade (GMP-grade)...
November 15, 2023: Stem Cells Translational Medicine