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https://www.readbyqxmd.com/read/27861428/hepatogenic-differentiation-of-human-induced-pluripotent-stem-cells-on-collagen-coated-polyethersulfone-nanofibers
#1
Maryam Mahmoodinia Maymand, Hamid Reza Soleimanpour-Lichaei, Abdolreza Ardeshirylajimi, Masoud Soleimani, Samaneh Mirzaei, Athena Hajarizadeh, Maryam Kabir Salmani
Many scientists have been fascinated with Induced pluripotent stem cells (iPSCs) for cell replacement therapies. Nanofibrous biocompatible scaffolds have been shown to promote better cell adhesion and improve stem cell differentiation. In the present study, after fabrication using electrospinning technique and surface modifications, the characteristics of Polyethersulfone (PES) nanofibers were determined by scanning electron microscopy (SEM), ATR-FTIR and MTT assay. Then, the hepatogenic potential of iPSCs was evaluated using Real-Time RT-PCR and immunocytochemistry (ICC) after culture on collagen coated polyethersulfone (PES/COL) scaffolds...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27784345/-changes-of-adamts13-activity-and-tsp1-level-in-patients-with-hematologic-malignancies
#2
Cai-Feng Sun, Xia Zhao, Fang Han, Qi Jia, Liang Wang, Guang Lu, Hui-Fang Ding
OBJECTIVE: To investigate the changes of thrombospondin 1(TSP1) level and von Willebrand factor cleaving protease(ADAMTS13) activity in the patients with hematologic malignancies before and after treatment and to evaluate their clinical significance. METHODS: Eighty-two patients with hematologic malignancies were enrolled in this study, among them 20 patients were with acute leukemia, 48 patients were with lymphoma and 14 patients were with multiple myeloma. The plasma samples of 82 patients with hematologic malignancies and 45 healthy controls were collected...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27779587/the-renin-inhibitor-aliskiren-protects-rat-lungs-from-the-histopathological-effects-of-fat-embolism
#3
Amanda N Fletcher, Agostino Molteni, Rakesh Ponnapureddy, Chirag Patel, Mark Pluym, Alan M Poisner
BACKGROUND: Fat embolism (FE) and the consequent fat embolism syndrome (FES) occurring after trauma or surgery can lead to serious pulmonary injury, including ARDS and death. Current treatment of FES is limited to supportive therapy. We have shown in a rat model that the renin angiotensin system (RAS) plays a significant role in the pathophysiology of FE since drugs interfering with the RAS, captopril and losartan, reduce the histopathologic pulmonary damage. The purpose of the current study was to determine if inhibition of renin by aliskiren, an FDA-approved drug for treating hypertension, would produce effective protection in the same model...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27755171/microneedling-a-comprehensive-review
#4
Angela Hou, Brandon Cohen, Adele Haimovic, Nada Elbuluk
BACKGROUND: Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The microwounds created stimulate the release of growth factors and induce collagen production. The epidermis remains relatively intact, therefore helping to limit adverse events. The indications for microneedling therapy have grown significantly, and it is becoming a more widely used treatment in dermatology. OBJECTIVE: A comprehensive review of microneedling in human subjects and its applications in dermatology...
October 13, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27737805/differentiation-of-nerve-derived-adult-pluripotent-stem-cells-into-osteoblastic-and-endothelial-cells
#5
Shang-You Yang, Nora Strong, Xuan Gong, Michael H Heggeness
BACKGROUND: Stem cell-involved tissue engineering has gained dramatic attention as a therapeutic strategy for tissue regeneration including bone repair. However, the currently available possibilities to use embryonic stem cells and induced pluripotent stem cells (iPCs) face potential ethical issues, as well as risks of malignant transformation and immune rejection. Recently identified peripheral nerve-derived adult pluripotent cells (NEDAPS) that quickly proliferate after exposure to BMP-2 or nerve trauma and exhibit many embryonic stem cell characteristics may provide an attractive source cells for a variety of regenerative therapies...
October 10, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27661759/low-level-laser-therapy-904nm-can-increase-collagen-and-reduce-oxidative-and-nitrosative-stress-in-diabetic-wounded-mouse-skin
#6
José Carlos Tatmatsu-Rocha, Cleber Ferraresi, Michael R Hamblin, Flávio Damasceno Maia, Nilberto Robson Falcão do Nascimento, Patricia Driusso, Nivaldo Antonio Parizotto
BACKGROUND AND OBJECTIVE: Over the last decade we have seen an increased interest in the use of Low-Level Laser Therapy (LLLT) in diseases that involve increased oxidative stress. It is well established that hyperglycemia in diabetes elicits a rise in reactive oxygen species (ROS) production but the effect of LLLT remains unclear. This study aimed to investigate whether LLLT was able to improve oxidative/nitrosative stress parameters in the wound healing process in diabetic mice. STUDY DESIGN/MATERIALS AND METHODS: Twenty male mice were divided into four groups: non-irradiated control (NIC), irradiated control (IC), non-irradiated and diabetic (NID), irradiated and diabetic (ID)...
November 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27637777/scaffold-based-delivery-of-bone-marrow-mesenchymal-stem-cell-sheet-fragments-enhances-new-bone-formation-in%C3%A2-vivo
#7
Ge Ma, Jin-Long Zhao, Ming Mao, Jie Chen, Zhi-Wei Dong, Yan-Pu Liu
PURPOSE: Stem cell therapy is becoming a potent strategy to shorten the consolidation time and reduce potential complications during distraction osteogenesis (DO). However, the conventional local injection or scaffold-based delivery of bone marrow mesenchymal stem cell (BMSC) suspension deprives the cells of their endogenous extracellular matrix, which might dampen cell differentiation and tissue regeneration after implantation. Therefore, in our study, a BMSC sheet was established and was then minced into fragments and loaded onto a hydroxyapatite (HA) scaffold for grafting...
August 24, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27630718/induction-of-tenogenic-differentiation-mediated-by-extracellular-tendon-matrix-and-short-term-cyclic-stretching
#8
Janina Burk, Amelie Plenge, Walter Brehm, Sandra Heller, Bastian Pfeiffer, Cornelia Kasper
Tendon and ligament pathologies are still a therapeutic challenge, due to the difficulty in restoring the complex extracellular matrix architecture and biomechanical strength. While progress is being made in cell-based therapies and tissue engineering approaches, comprehensive understanding of the fate of progenitor cells in tendon healing is still lacking. The aim of this study was to investigate the effect of decellularized tendon matrix and moderate cyclic stretching as natural stimuli which could potentially direct tenogenic fate...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27582519/bmp7-based-functionalized-self-assembling-peptides-protect-nucleus-pulposus-derived-stem-cells-from-apoptosis-in-vitro
#9
Xiao-Chuan Li, Yao-Hong Wu, Xue-Dong Bai, Wei Ji, Zi-Ming Guo, Chao-Feng Wang, Qing He, Di-Ke Ruan
Tissue engineering has shown great success in the treatment of intervertebral disk degeneration (IVDD) in the past decade. However, the adverse and harsh microenvironment associated in the intervertebral disks remains a great obstacle for the survival of transplanted cells. Although increasing numbers of new materials have been created or modified to overcome this hurdle, a new effective strategy of biological therapy is still required. In this study, bone morphogenic protein 7 (BMP7)-based functionalized self-assembling peptides were developed by conjugating a bioactive motif from BMP-7 (RKPS) onto the C-terminal of the peptide RADARADARADARADA (RADA16-I) at a ratio of 1:1 to form a new RADARKPS peptide...
October 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27579476/therapeutic-effect-of-ergotope-peptides-on-cia-by-down-regulation-of-inflammatory-and-th1-th17-responses-and-induction-of-regulatory-t-cells
#10
Xiaoyin Niu, Shaohua Deng, Shan Li, Yebin Xi, Chengzhen Li, Li Wang, Dongyi He, Zhaojun Wang, Guangjie Chen
Rheumatoid arthritis (RA) is a systemic autoimmune disease that results in a chronic and inflammatory disorder. Dynamic balance of helper T cells (Th)1, Th17 and regulatory T cells (Treg) is broken in RA. Since there is no cure for RA at present, it's necessary to find a truly effective and convenient treatment. Several studies intended to induce ergotopic regulation to treat autoimmune diseases. This study was undertaken to find the potential ergotope peptides and investigate its effect in treating the animal model of RA and their underlying regulatory mechanisms...
August 30, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27534902/sirtuin-6-suppresses-hypoxia-induced-inflammatory-response-in-human-osteoblasts-via-inhibition-of-reactive-oxygen-species-production-and-glycolysis-a-therapeutic-implication-in-inflammatory-bone-resorption
#11
Kuo-Liang Hou, Sze-Kwan Lin, Ling-Hsiu Chao, Eddie Hsiang-Hua Lai, Cheng-Chi Chang, Chia-Tung Shun, Wan-Yu Lu, Jyh-Horng Wang, Michael Hsiao, Chi-Yuan Hong, Sang-Heng Kok
Elevated glycolytic activity and redox imbalance induced by tissue hypoxia are common phenomena of chronic inflammation, including inflammatory bone diseases such as arthritis. However, relation between glycolysis and redox signaling in the inflammatory milieu is unclear. The histone deacetylase sirtuin 6 (SIRT6) is a crucial modulator of inflammation and glucose metabolism, and it is also involved in cellular protection against oxidative injury. The aims of the study were to examine the connection between glycolysis and reactive oxygen species (ROS) production in human osteoblastic cells (HOB) and whether SIRT6 modulates inflammatory response via regulation of glycolytic activity and ROS generation...
August 18, 2016: BioFactors
https://www.readbyqxmd.com/read/27516061/apoptotic-cell-infusion-treats-ongoing-collagen-induced-arthritis-even-in-the-presence-of-methotrexate-and-is-synergic-with-anti-tnf-therapy
#12
Francis Bonnefoy, Anna Daoui, Séverine Valmary-Degano, Eric Toussirot, Philippe Saas, Sylvain Perruche
BACKGROUND: Apoptotic cell-based therapies have been proposed to treat chronic inflammatory diseases. The aim of this study was to investigate the effect of intravenous (i.v.) apoptotic cell infusion in ongoing collagen-induced arthritis (CIA) and the interaction of this therapy with other treatments used in rheumatoid arthritis (RA), including methotrexate (MTX) or anti-TNF therapy. METHODS: The effects of i.v. apoptotic cell infusion were evaluated in a CIA mouse model in DBA/1 mice immunized with bovine type II collagen...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27510285/fractional-carbon-dioxide-laser-versus-low-dose-uva-1-phototherapy-for-treatment-of-localized-scleroderma-%C3%A2-a-clinical-and-immunohistochemical-randomized-controlled-study
#13
S M Shalaby, M Bosseila, M M Fawzy, D M Abdel Halim, S S Sayed, R S H M Allam
Morphea is a rare fibrosing skin disorder that occurs as a result of abnormal homogenized collagen synthesis. Fractional ablative laser resurfacing has been used effectively in scar treatment via abnormal collagen degradation and induction of healthy collagen synthesis. Therefore, fractional ablative laser can provide an effective modality in treatment of morphea. The study aimed at evaluating the efficacy of fractional carbon dioxide laser as a new modality for the treatment of localized scleroderma and to compare its results with the well-established method of UVA-1 phototherapy...
November 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27492167/fibrosis-inducing-strategies-in-regenerating-dystrophic-and-normal-skeletal-muscle
#14
Patrizia Pessina, Pura Muñoz-Cánoves
The excessive accumulation of collagens (fibrosis) impairs the function of vital tissues and organs. Fibrosis is a hallmark of severe muscular dystrophies, such as the incurable Duchenne Muscular Dystrophy (DMD), where skeletal muscle is substituted by scar (fibrotic) tissue as disease advances. One of the major obstacles in increasing our ability to combat fibrosis-driven muscular dystrophy progression is that no optimal in vivo models of muscle fibrosis are currently available, limiting fibrosis research and the development of novel therapies...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27477297/nrf2-knockdown-attenuates-the-ameliorative-effects-of-ligustrazine-on-hepatic-fibrosis-by-targeting-hepatic-stellate-cell-transdifferentiation
#15
Chunfeng Lu, Wenxuan Xu, Feng Zhang, Jiangjuan Shao, Shizhong Zheng
Hepatic fibrosis is a frequent reparative process in response to chronic liver injury and inflammation, which is mainly attributed to hepatic stellate cell (HSC) activation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) was recently highlighted for its negative regulation of HSC behaviors. Our previous studies have revealed the potent antifibrotic effects of ligutrazine without elaborating potential molecular mechanisms. In this work, our in vitro results showed that ligustrazine significantly enhanced Nrf2 expression and nuclear translocation in HSC...
July 15, 2016: Toxicology
https://www.readbyqxmd.com/read/27448409/effect-of-platelet-mediator-concentrate-pmc-on-achilles-tenocytes-an-in-vitro-study
#16
Esra Arslan, Thomas Nellesen, Andreas Bayer, Andreas Prescher, Sebastian Lippross, Sven Nebelung, Holger Jahr, Christine Jaeger, Wolf Dietrich Huebner, Horst Fischer, Marcus Stoffel, Mehdi Shakibaei, Thomas Pufe, Mersedeh Tohidnezhad
BACKGROUND: Although there are many studies discussing the etiological and pathological factors leading to both, acute and chronic tendon injuries, the pathophysiology of tendon injuries is still not clearly understood. Although most lesions are uncomplicated, treatment is long and unsatisfactory due to the poor vascularity of tendon tissue. Platelet mediator concentrate (PMC) contains many growth factors derived from platelets, which can promote wound healing. In this study we investigate the effects of PMC on tenocyte proliferation and differentiation in order to provide an experimental basis for tissue regeneration strategies and to develop new treatment concepts...
July 22, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27421741/effects-of-hypoxia-on-osteogenic-differentiation-of-mesenchymal-stromal-cells-used-as-a-cell-therapy-for-avascular-necrosis-of-the-femoral-head
#17
Gabriela Ciapetti, Donatella Granchi, Caterina Fotia, Lucia Savarino, Dante Dallari, Nicola Del Piccolo, Davide Maria Donati, Nicola Baldini
BACKGROUND AIMS: Avascular necrosis of the femoral head (AVN) occurs as common result of various conditions or develops as a primary entity, with a high freqency in young adults. Because of its tendency toward osteoarthritis requiring total hip arthroplasty, alternative treatments are being advocated, including cell therapy with mesenchymal stromal cells (MSCs). Because osteonecrotic bone is a severely hypoxic tissue, with a 1-3% oxygen tension, the survival and function of multipotent cells is questionable...
September 2016: Cytotherapy
https://www.readbyqxmd.com/read/27417692/induction-of-mice-adult-bone-marrow-mesenchymal-stem-cells-into-functional-motor-neuron-like-cells
#18
Rafal H Abdullah, Nahi Y Yaseen, Shahlaa M Salih, Ahmad Adnan Al-Juboory, Ayman Hassan, Ahmed Majeed Al-Shammari
The differentiation of mesenchymal stem cells (MSC) into acetylcholine secreted motor neuron-like cells, followed by elongation of the cell axon, is a promising treatment for spinal cord injury and motor neuron cell dysfunction in mammals. Differentiation is induced through a pre-induction step using Beta- mercaptoethanol (BME) followed by four days of induction with retinoic acid and sonic hedgehog. This process results in a very efficient differentiation of BM-MSCs into motor neuron-like cells. Immunocytochemistry showed that these treated cells had specific motor neural markers: microtubule associated protein-2 and acetylcholine transferase...
July 11, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27400798/epidermal-growth-factor-tethered-to-%C3%AE-tricalcium-phosphate-bone-scaffolds-via-a-high-affinity-binding-peptide-enhances-survival-of-human-mesenchymal-stem-cells-multipotent-stromal-cells-in-an-immune-competent-parafascial-implantation-assay-in-mice
#19
Austin Nuschke, Melanie Rodrigues, Jaime Rivera, Cecelia Yates, Diana Whaley, Donna Stolz, Linda Griffith, Alan Wells
: : Mesenchymal stem cells/multipotent stromal cells (MSCs) are attractive candidates for cell therapies owing to their ability to differentiate into many lineages. However, these cells often fail to survive when implanted into a harsh wound environment, limiting efficacy in vivo. To improve MSC survival, we previously found that tethered epidermal growth factor (tEGF) molecules that restrict epidermal growth factor receptor (EGFR) signaling to the cell surface provide resistance to death signals...
July 8, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27365484/mesenchymal-stem-cell-spheroids-retain-osteogenic-phenotype-through-%C3%AE-2%C3%AE-1-signaling
#20
Kaitlin C Murphy, Allison I Hoch, Jenna N Harvestine, Dejie Zhou, J Kent Leach
UNLABELLED: : The induction of mesenchymal stem cells (MSCs) toward the osteoblastic lineage using osteogenic supplements prior to implantation is one approach under examination to enhance their bone-forming potential. MSCs rapidly lose their induced phenotype upon removal of the soluble stimuli; however, their bone-forming potential can be sustained when provided with continued instruction via extracellular matrix (ECM) cues. In comparison with dissociated cells, MSC spheroids exhibit improved survival and secretion of trophic factors while maintaining their osteogenic potential...
September 2016: Stem Cells Translational Medicine
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