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Jordi Sans-Roselló, Gregori Casals, Xavier Rosselló, Bernardino González de la Presa, Montserrat Vila, Albert Duran-Cambra, Manuel Morales-Ruiz, Andreu Ferrero-Gregori, Wladimiro Jiménez, Alessandro Sionis
BACKGROUND: The use of plasma biomarkers is relevant for the prognosis of ST-segment elevation myocardial infarction (STEMI) patients. Apelin, an adipocytokine, plays a pivotal role in the pathophysiology of both ischemia/reperfusion injury and its potential subsequent heart failure. We evaluated apelin concentrations at admission as a biomarker to assess risk of 6-month mortality. METHODS: Consecutive patients with STEMI were recruited from January 2012 to January 2013 (n=250)...
November 23, 2016: Clinical Biochemistry
Diana María Valero-Hervás, Elena Sánchez-Zapardiel, María José Castro, Fernando Gallego-Bustos, Félix Cambra, Iago Justo, Rocío Laguna-Goya, Carlos Jiménez-Romero, Enrique Moreno, Francisco López-Medrano, Rafael San Juan, Mario Fernández-Ruiz, José María Aguado, Estela Paz-Artal
Complement component 3 (C3) presents both slow (C3S) and fast (C3F) variants, which can be locally-produced and activated by immune system cells. We studied C3 recipient variants in 483 liver transplant patients by RT-PCR-HRM to determine their effect on graft outcome during the first year post-transplantation. Allograft survival was significantly decreased in C3FF recipients (C3SS 95% vs. C3FS 91% vs. C3FF 83%; p=0.01) or C3F allele carriers (C3F-absence 95% vs. C3F-presence 90%, p=0.02). C3FF genotype or presence of C3F allele independently increased risk for allograft loss (OR: 2...
November 1, 2016: Clinical Transplantation
K Cambra, A Galbete, L Forga, O Lecea, M J Ariz, C Moreno-Iribas, F Aizpuru, B Ibañez
BACKGROUND: We aimed to determine the degree to which control targets of glycaemia and cardiovascular risk factors were achieved among patients with type 2 diabetes and to investigate sex- and age-related differences in this population. METHODS: This cross-sectional, population-based study was conducted in Spain. Glycated hemoglobin (HbA1c), blood pressure, LDL-c, HDL-c, triglycerides, BMI, and smoking history were obtained from electronic clinical primary care records (n = 32,638 cases)...
October 12, 2016: BMC Family Practice
Ana Flo, Trinitat Cambras, Antoni Díez-Noguera, Ana Calpena
Melatonin is a neurohormone with multiple and different actions, such as chronobiotic or antioxidant. Melatonin is usually orally administered, but dermal administration is also useful in dermatological diseases or as adjuvant to certain skin treatments. Here, we studied the variability of the pharmacokinetics of melatonin and its metabolite AFMK, when melatonin is transdermally administered to Hairless rat at two different times of day (Zeitgeber Time 4 (ZT4) and ZT16). Moreover, in order to obtain the bioavailability, kinetics after intravenous administration was also studied...
September 16, 2016: European Journal of Pharmaceutical Sciences
B A Ali, M Fortún, T Belzunegui, B Ibañez, K Cambra, A Galbete
BACKGROUND: Trauma registries (TR) collect information about trauma patients according to inclusion criteria, and it helps to establish protocols to improve care. However, all TR deal with incompleteness. The aim of this study is to assess the number of patients not included despite fulfilling inclusion criteria in our regional TR and identifying the predictors for being missing. METHODS: The sample was randomly selected. Two months of each year from 2010 to 2014 (5 years) were selected, and medical files of all patients attended in the emergency department room during those months were studied...
August 23, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Xavier Rossello, Montserrat Vila, Mercedes Rivas-Lasarte, Andreu Ferrero-Gregori, Jordi Sans-Roselló, Albert Duran-Cambra, Alessandro Sionis
OBJECTIVES: The impact of pulmonary artery catheterization (PAC) on survival in patients with cardiogenic shock (CS) is not well established. This study aimed to assess whether Swan-Ganz catheter monitoring is related to short- and long-term mortality in patients with CS. METHODS: One hundred and twenty-nine consecutive patients with a first admission for CS were prospectively enrolled in a single-center registry between December 2005 and May 2009, and were subsequently followed up over 5...
August 24, 2016: Cardiology
Nieves Candelas González, Josefina Rascón Pérez, Beatriz Chamero, Oscar Cambra-Moo, Armando González Martín
The methodology for sex determination in human skeletal remains depends on the different bone morphologies presented by men and women. Due to their direct implications in reproduction, the whole pelvis, particularly the os coxae, shows different characteristics in either sex. The sacrum and the os coxae constitute the birth canal. In this research study, the os coxae shape is analyzed using geometric morphometrics, providing information on morphology, regardless of size or any other factor beyond the geometry itself...
August 3, 2016: Journal of Anatomy
Elena Rubio-Abadal, Núria Del Cacho, Gerard Saenz-Navarrete, Belen Arranz, Rosa-Maria Cambra, Daniel Cuadras, Demián Rodante, Csaba Fehér, Mercedes Roca, Vanessa Barneda, Judith Usall
OBJECTIVE: We aimed to study the relationship between hyperprolactinemia (HPRL) and sexual dysfunction (SED) in a sample of patients being prescribed a dose-stable antipsychotic medication, and to evaluate sex differences in the prevalence of HPRL and SED and their relationship. METHOD: A cross-sectional study was carried out including patients between 18 and 55 years of age with a psychotic spectrum diagnosis who were attending community mental health services or hospitalized in medium and long stay units...
October 2016: Journal of Clinical Psychopharmacology
Juan Ignacio Arraras, Berta Hernandez, Maite Martinez, Koldo Cambra, Mikel Rico, Jose Juan Illarramendi, Antonio Viudez, Berta Ibañez, Uxue Zarandona, Enrique Martinez, Ruth Vera
PURPOSE: This paper studies the Quality of Life (QL) of Spanish advanced non-small-cell lung cancer (NSCLC) patients receiving platinum-doublet chemotherapy, compares our results with those from studies from other cultural areas, and identifies factors associated with global QL and survival prognostic variables. METHODS: EORTC QLQ-C30 and QLQ-LC13 questionnaires were completed three times by 39 patients along treatment and follow-up. Univariate and multivariate logistic regression analyses were performed to study global QL determinants (≤50 points considered low global-QL score)...
2016: SpringerPlus
Claire Mills, Piyush Patel
Caries management by risk assessment (CAMBRA) is an evidence-based model intended to provide dentists with a protocol for diagnosis, treatment, and prevention of caries by assessing and addressing a patient's overall oral health. The aim of this review was to examine the literature on CAMBRA to determine its efficacy. Clinical studies demonstrate that the CAMBRA approach is an effective concept that is both predictive of dental caries development and accurate in outlining appropriate treatment options and preventive strategies that can reduce the morbidity of this common disease process across all patient demographics...
July 2016: General Dentistry
Nicole Colin, Alberto Maceda-Veiga, Núria Flor-Arnau, Josep Mora, Pau Fortuño, Cristiana Vieira, Narcís Prat, Jaume Cambra, Adolfo de Sostoa
The textile industry is one of the largest sectors globally, representing up to 20% of industrial water pollution. However, there is limited insight into how fluvial ecosystems respond and recover from this impact. From summer 2012 to spring 2013, we examined water quality and ecological status upstream and 1.5km downstream the input of a textile industry wastewater treatment plant (WWTP) in Ripoll River, NE Spain. The ecological status was determined via diversity measures and 10 biotic indices based on diatoms, macrophytes, macroinvertebrates and fish...
October 2016: Ecotoxicology and Environmental Safety
Antonio Lalueza, Félix Cambra, María Urbanowicz, Rafael San Juan, Guadalupe López-Alonso, José María Aguado
No abstract text is available yet for this article.
July 2016: Journal of Clinical Microbiology
Antonio Lalueza, Félix Cambra, María Urbanowicz, Rafael San Juan, Guadalupe López-Alonso, José María Aguado
No abstract text is available yet for this article.
July 2016: Journal of Clinical Microbiology
M Fernández-Ruiz, J T Silva, F López-Medrano, L M Allende, R San Juan, F Cambra, I Justo, E Paz-Artal, C Jiménez, J M Aguado
BACKGROUND: Monitoring of peripheral blood lymphocyte subpopulation (PBLS) counts might be useful for estimating the risk of infection after liver transplantation (LT). METHODS: We prospectively measured total lymphocyte and PBLS counts at baseline and post-transplant months 1 and 6 in 92 LT recipients. PBLS were enumerated by single-platform 6-color flow cytometry technology. Areas under receiver operating characteristic (ROC) curves were used to evaluate the accuracy of different PBLS for predicting cytomegalovirus (CMV) disease and overall opportunistic infection (OI)...
August 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
K Bizkarra, V L Barrio, P L Arias, J F Cambra
In the present work m-xylene and an equimolecular mixture of m-xylene, 1-butanol and furfural, all of them bio-oil model compounds, were studied in steam reforming (SR) conditions. Three different nickel catalysts, which showed to be active in 1-butanol SR (Ni/Al2O3, Ni/CeO2-Al2O3 and Ni/La2O3-Al2O3), were tested and compared with thermodynamic equilibrium values. Tests were carried out at temperatures from 800 to 600°C at atmospheric pressure with a steam to carbon ratio (S/C) of 5.0. Despite the different bio-oils fed, the amount of moles going through the catalytic bed was kept constant in order to obtain comparable results...
September 2016: Bioresource Technology
Luis Forga, María José Goñi, Berta Ibáñez, Koldo Cambra, Marta García-Mouriz, Ana Iriarte
Aim. To determine the influence of age at onset of type 1 diabetes and of traditional vascular risk factors on the development of diabetic retinopathy, in a cohort of patients who have been followed up after onset. Methods. Observational, retrospective study. The cohort consists of 989 patients who were followed up after diagnosis for a mean of 10.1 (SD: 6.8) years. The influence of age at diagnosis, glycemic control, duration of diabetes, sex, blood pressure, lipids, BMI, and smoking is analyzed using Cox univariate and multivariate models with fixed and time-dependent variables...
2016: Journal of Diabetes Research
Christian Stephan-Otto, Sara Siddi, Jorge Cuevas Esteban, Carl Senior, Roberto García-Álvarez, Maria Rosa Cambra-Martí, Judith Usall, Gildas Brébion
BACKGROUND: Abnormalities in visual processes have been observed in schizophrenia patients and have been associated with alteration of the lateral occipital complex and visual cortex. However, the relationship of these abnormalities with clinical symptomatology is largely unknown. METHODS: We investigated the brain activity associated with object perception in schizophrenia. Pictures of common objects were presented to 26 healthy participants (age=36.9; 11 females) and 20 schizophrenia patients (age=39...
August 2016: Schizophrenia Research
J Calvo Pulido, M Manrique Municio, C Loinaz Segurola, I Justo Alonso, O Caso Maestro, A García-Sesma, F Cambra Molero, R San-Juan Garrido, M Abradelo de Usera, A Marcacuzco Quinto, E Moreno González, C Jiménez Romero
BACKGROUND: Surgical complications in multivisceral transplantation (MVT) are frequent and always severe. Those related to technical issues are relevant as they have implications not only on the graft but also on patient survival. The aim of this study was to review our case-based data and experience with 5 MVT performed since December 2004. CASE REPORT: A 38 year-old woman presented with ultra-short bowel syndrome due to massive ischemia also affecting the celiac trunk...
March 2016: Transplantation Proceedings
Juan Ignacio Arraras, Ana Manterola, Gemma Asin, Jose Juan Illarramendi, Susana de la Cruz, Berta Ibañez, Josu Delfrade, Esteban Salgado, Uxue Zarandona, Koldo Cambra, Ruth Vera, Miguel Angel Dominguez
PURPOSE: There is a debate on the role of adjuvant Radiotherapy (RT) in elderly breast cancer patients. The aim is to study Quality of Life (QL) throughout the treatment and follow-up periods in early stages breast cancer patients who have started radiotherapy, and to compare the QL of axillary surgery groups. METHODS: 173 patients, ≥65 years completed the EORTC QLQ-C30 and QLQ-BR23, and the Interview for Deterioration in Daily Living Activities in Dementia(IDDD) questionnaires three times throughout treatment and follow-up periods...
April 2016: Breast: Official Journal of the European Society of Mastology
Jordi Aguiló, Pau Ferrer-Salvans, Antonio García-Rozo, Antonio Armario, Ángel Corbí, Francisco J Cambra, Raquel Bailón, Ana González-Marcos, Gerardo Caja, Sira Aguiló, Raúl López-Antón, Adriana Arza-Valdés, Jorge M Garzón-Rey
No abstract text is available yet for this article.
April 1, 2016: Revista de Neurologia
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