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GLV-1h153

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https://www.readbyqxmd.com/read/27119120/molecular-network-pathway-and-functional-analysis-of-time-dependent-gene-changes-associated-with-pancreatic-cancer-susceptibility-to-oncolytic-vaccinia-virotherapy
#1
Dana Haddad, Nicholas Socci, Chun-Hao Chen, Nanhai G Chen, Qian Zhang, Susanne G Carpenter, Arjun Mittra, Aladar A Szalay, Yuman Fong
BACKGROUND: Pancreatic cancer is a fatal disease associated with resistance to conventional therapies. This study aimed to determine changes in gene expression patterns associated with infection and susceptibility of pancreatic cancer cells to an oncolyticvaccinia virus, GLV-1h153, carrying the human sodium iodide symporter for deep tissue imaging of virotherapy. METHODS: Replication and susceptibility of pancreatic adenocarcinoma PANC-1 cells to GLV-1h153 was confirmed with replication and cytotoxicity assays...
2016: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/26814609/oncolytic-vaccinia-virus-as-a-vector-for-therapeutic-sodium-iodide-symporter-gene-therapy-in-prostate-cancer
#2
D C Mansfield, J N Kyula, N Rosenfelder, J Chao-Chu, G Kramer-Marek, A A Khan, V Roulstone, M McLaughlin, A A Melcher, R G Vile, H S Pandha, V Khoo, K J Harrington
Oncolytic strains of vaccinia virus are currently in clinical development with clear evidence of safety and promising signs of efficacy. Addition of therapeutic genes to the viral genome may increase the therapeutic efficacy of vaccinia. We evaluated the therapeutic potential of vaccinia virus expressing the sodium iodide symporter (NIS) in prostate cancer models, combining oncolysis, external beam radiotherapy and NIS-mediated radioiodide therapy. The NIS-expressing vaccinia virus (VV-NIS), GLV-1h153, was tested in in vitro analyzes of viral cell killing, combination with radiotherapy, NIS expression, cellular radioiodide uptake and apoptotic cell death in PC3, DU145, LNCaP and WPMY-1 human prostate cell lines...
April 2016: Gene Therapy
https://www.readbyqxmd.com/read/25616946/gene-therapy-using-therapeutic-and-diagnostic-recombinant-oncolytic-vaccinia-virus-glv-1h153-for-management-of-colorectal-peritoneal-carcinomatosis
#3
Clarisse Eveno, Kelly Mojica, Justin W Ady, Daniel L J Thorek, Valerie Longo, Laurence J Belin, Sepideh Gholami, Clark Johnsen, Pat Zanzonico, Nanhai Chen, Tony Yu, Aladar A Szalay, Yuman Fong
BACKGROUND: Peritoneal carcinomatosis (PC) is a terminal progression of colorectal cancer (CRC). Poor response to cytoreductive operation and chemotherapy coupled with the inability to reliably track disease progression by the use of established diagnostic methods, make this a deadly disease. We examined the effectiveness of the oncolytic vaccinia virus GLV-1h153 as a therapeutic and diagnostic vehicle. We believe that viral expression of the human sodium iodide transporter (hNIS) provides both real-time monitoring of viral therapy and effective treatment of colorectal peritoneal carcinomatosis (CRPC)...
February 2015: Surgery
https://www.readbyqxmd.com/read/24186964/vaccinia-virus-glv-1h153-in-combination-with-131i-shows-increased-efficiency-in-treating-triple-negative-breast-cancer
#4
Sepideh Gholami, Chun-Hao Chen, Emil Lou, Laurence J Belin, Sho Fujisawa, Valerie A Longo, Nanhai G Chen, Mithat Gönen, Pat B Zanzonico, Aladar A Szalay, Yuman Fong
We investigated the therapeutic efficacy of a replication-competent oncolytic vaccinia virus, GLV-1h153, carrying human sodium iodide symporter (hNIS), in combination with radioiodine in an orthotopic triple-negative breast cancer (TNBC) murine model. In vitro viral infection was confirmed by immunoblotting and radioiodine uptake assays. Orthotopic xenografts (MDA-MB-231 cells) received intratumoral injection of GLV-1h153 or PBS. One week after viral injection, xenografts were randomized into 4 treatment groups: GLV-1h153 alone, GLV-1h153 and (131)I (∼ 5 mCi), (131)I alone, or PBS, and followed for tumor growth...
February 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/23890748/an-oncolytic-vaccinia-virus-expressing-the-human-sodium-iodine-symporter-prolongs-survival-and-facilitates-spect-ct-imaging-in-an-orthotopic-model-of-malignant-pleural-mesothelioma
#5
Laurence J Belin, Justin W Ady, Christina Lewis, Drew Marano, Sepideh Gholami, Kelly Mojica, Clarisse Eveno, Valerie Longo, Pat B Zanzonico, Nanhai G Chen, Aladar A Szalay, Yuman Fong
BACKGROUND: The purpose of this work was to examine the ability of an oncolytic vaccinia virus expressing the human sodium iodine transporter (hNIS) to provide real time monitoring of viral therapy and effective treatment of malignant pleural mesothelioma (MPM). METHODS: Infectivity and cytotoxic effects of GLV-1h153 on mesothelioma cell lines of all histologic subtypes were assayed in vitro. Viral replication was examined by standard viral plaque assay. Orthotopic MPM xenografts were generated in athymic nude mice, treated with intrapleural GLV-1h153, and assessed for effect on tumor burden and survival...
September 2013: Surgery
https://www.readbyqxmd.com/read/23824643/triple-negative-breast-cancer-new-perspectives-for-novel-therapies
#6
REVIEW
Yashin A Mahamodhossen, Wei Liu, Zhou Rong-Rong
Triple-negative breast cancer (TNBC) represents 10-20 % of all mammary tumors. It is often found in younger women and has been associated with poor prognosis, due to aggressive tumor phenotype(s), early metastasis to visceral organ or brain after chemotherapy and present lack of clinically established targeted therapies. In recent years, a greater understanding of the biology of this disease has led to the development of numerous and varied therapeutic approaches, especially the trials on poly (ADP-ribose) polymerase inhibitors BSI-201 and olaparib, and antiangiogenic agents such as bevacizumab and sunitinib, which have raised hopes in the treatment for TNBC and BRCA1/2-positive disease...
2013: Medical Oncology
https://www.readbyqxmd.com/read/23506710/vaccinia-virus-glv-1h153-is-a-novel-agent-for-detection-and-effective-local-control-of-positive-surgical-margins-for-breast-cancer
#7
Sepideh Gholami, Chun-Hao Chen, Laurence J Belin, Emil Lou, Sho Fujisawa, Caroline Antonacci, Amanda Carew, Nanhai G Chen, Marina De Brot, Pat B Zanzonico, Aladar A Szalay, Yuman Fong
INTRODUCTION: Surgery is currently the definitive treatment for early-stage breast cancer. However, the rate of positive surgical margins remains unacceptably high. The human sodium iodide symporter (hNIS) is a naturally occurring protein in human thyroid tissue, which enables cells to concentrate radionuclides. The hNIS has been exploited to image and treat thyroid cancer. We therefore investigated the potential of a novel oncolytic vaccinia virus GLV1h-153 engineered to express the hNIS gene for identifying positive surgical margins after tumor resection via positron emission tomography (PET)...
2013: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/23139088/a-vaccinia-virus-encoding-the-human-sodium-iodide-symporter-facilitates-long-term-image-monitoring-of-virotherapy-and-targeted-radiotherapy-of-pancreatic-cancer
#8
Dana Haddad, Pat B Zanzonico, Sean Carlin, Chun-Hao Chen, Nanhai G Chen, Qian Zhang, Yong A Yu, Valerie Longo, Kelly Mojica, Richard J Aguilar, Aladar A Szalay, Yuman Fong
UNLABELLED: To assess therapeutic response and potential toxicity of oncolytic virotherapy, a noninvasive, deep-tissue imaging modality is needed. This study aimed to assess the feasibility, parameters, and determining factors of serial imaging and long-term monitoring of virotherapy and the therapeutic response of pancreatic cancer xenografts treated with a vaccinia virus carrying the human sodium iodide symporter GLV-1h153. METHODS: Pancreatic cancer xenografts (PANC-1) in nude mice were treated systemically or intratumorally with GLV-1h153 and serially imaged using (124)I PET at 1, 2, 3, and 5 wk after viral injection...
December 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/22912675/imaging-characteristics-tissue-distribution-and-spread-of-a-novel-oncolytic-vaccinia-virus-carrying-the-human-sodium-iodide-symporter
#9
Dana Haddad, Chun-Hao Chen, Sean Carlin, Gerd Silberhumer, Nanhai G Chen, Qian Zhang, Valerie Longo, Susanne G Carpenter, Arjun Mittra, Joshua Carson, Joyce Au, Mithat Gonen, Pat B Zanzonico, Aladar A Szalay, Yuman Fong
INTRODUCTION: Oncolytic viruses show promise for treating cancer. However, to assess therapy and potential toxicity, a noninvasive imaging modality is needed. This study aims to determine the in vivo biodistribution, and imaging and timing characteristics of a vaccinia virus, GLV-1h153, encoding the human sodium iodide symporter (hNIS. METHODS: GLV-1h153 was modified from GLV-1h68 to encode the hNIS gene. Timing of cellular uptake of radioiodide (131)I in human pancreatic carcinoma cells PANC-1 was assessed using radiouptake assays...
2012: PloS One
https://www.readbyqxmd.com/read/22868370/vaccinia-virus-glv-1h153-is-effective-in-treating-and-preventing-metastatic-triple-negative-breast-cancer
#10
Sepideh Gholami, Chun-Hao Chen, Emil Lou, Marina De Brot, Sho Fujisawa, Nanhai G Chen, Aladar A Szalay, Yuman Fong
OBJECTIVE: This study aimed to investigate the therapeutic impact of a new oncolytic vaccinia virus in a triple-negative breast cancer (TNBC) murine model and its potential for treating distant metastatic disease. BACKGROUND: TNBCs are aggressive tumors associated with a high metastatic rate. Their lack of targets for hormonal/biological therapy presents significant clinical challenges and a dire need for novel therapies. METHODS: GLV-1h153, a replication-competent vaccinia virus, was tested against multiple cell lines...
September 2012: Annals of Surgery
https://www.readbyqxmd.com/read/22136819/novel-therapy-for-anaplastic-thyroid-carcinoma-cells-using-an-oncolytic-vaccinia-virus-carrying-the-human-sodium-iodide-symporter
#11
Sepideh Gholami, Dana Haddad, Chun-Hao Chen, Nanhai G Chen, Qian Zhang, Pat B Zanzonico, Aladar A Szalay, Yuman Fong
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is fatal with resistance to radiotherapy because of the loss of intrinsic human sodium iodine symporter (hNIS). We determined whether vaccinia virus carrying hNIS kills and induces hNIS reexpression in ATC cells, facilitating deep-tissue imaging. METHODS: Vaccinia virus (GLV-1h153) carrying hNIS was tested against ATC lines for killing and replication via cytotoxicity and viral plaque assays. Cellular radiouptake was determined using radiouptake assays...
December 2011: Surgery
https://www.readbyqxmd.com/read/21453532/insertion-of-the-human-sodium-iodide-symporter-to-facilitate-deep-tissue-imaging-does-not-alter-oncolytic-or-replication-capability-of-a-novel-vaccinia-virus
#12
Dana Haddad, Nanhai G Chen, Qian Zhang, Chun-Hao Chen, Yong A Yu, Lorena Gonzalez, Susanne G Carpenter, Joshua Carson, Joyce Au, Arjun Mittra, Mithat Gonen, Pat B Zanzonico, Yuman Fong, Aladar A Szalay
INTRODUCTION: Oncolytic viruses show promise for treating cancer. However, to assess therapeutic efficacy and potential toxicity, a noninvasive imaging modality is needed. This study aimed to determine if insertion of the human sodium iodide symporter (hNIS) cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a novel vaccinia virus, GLV-1h153. METHODS: GLV-1h153 was modified from parental vaccinia virus GLV-1h68 to carry hNIS via homologous recombination...
2011: Journal of Translational Medicine
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