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Geriatric assessment

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https://www.readbyqxmd.com/read/29935293/optimization-of-the-apop-screener-to-predict-functional-decline-or-mortality-in-older-emergency-department-patients-cross-validation-in-four-prospective-cohorts
#1
J de Gelder, J A Lucke, L C Blomaard, A M Booijen, A J Fogteloo, S Anten, E W Steyerberg, J Alsma, S C E Klein Nagelvoort Schuit, A Brink, B de Groot, G J Blauw, S P Mooijaart
INTRODUCTION: Many screening instruments to predict adverse health outcomes in older patients visiting the emergency department (ED) have been developed, but successful implementation has been hampered because they are insufficiently validated or not tailored for the intended use of everyday clinical practice. The present study aims to refine and validate an existing screening instrument (the APOP screener) to predict 90-day functional decline or mortality in older ED patients. METHODS: Consecutive older patients (≥70 years) visiting the EDs of four hospitals were included and prospectively followed...
June 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29934933/real-world-adverse-effects-of-capecitabine-toxicity-in-an-elderly-population
#2
Michiel W H van Beek, Monique Roukens, Wilco C H Jacobs, Johanna N H Timmer-Bonte, Cees Kramers
BACKGROUND: Few studies have assessed the safety and effectiveness of the numerous available chemotherapeutic therapies for geriatric oncology patients. Most safety studies are conducted in large trials, and there is some uncertainty surrounding whether the results would be the same in typical daily use. OBJECTIVE: This retrospective study aims to assess the adverse effects of real-world capecitabine use in elderly patients. METHODS: We reviewed the records of patients treated with capecitabine in an oncology department of a University Clinic in Nijmegen, The Netherlands...
June 22, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29934277/factors-associated-with-the-use-of-potentially-inappropriate-medications-by-older-adults-in-primary-health-care-an-analysis-comparing-ags-beers-eu-7-pim-list-and-brazilian-consensus-pim-criteria
#3
Thiago Augusto Almeida, Edna Afonso Reis, Isabela Vaz Leite Pinto, Maria das Graças Braga Ceccato, Micheline Rosa Silveira, Marina Guimarães Lima, Adriano Max Moreira Reis
BACKGROUND: Potentially inappropriate medications (PIM) for the older adults are those with an unfavorable risk-benefit ratio when more effective and safe therapeutic alternatives are available and is an important public health problem. PURPOSE: To analyze the factors associated with the use of PIM by the older adults and to investigate the agreement of PIM use frequency using the 2015 American Geriatric Society Beers Criteria for Potentially Inappropriate Medication Use in Older Adults - 2015 AGS Beers Criteria, the Brazilian consensus on potentially inappropriate medication for older adults (BCPIM) and the European union list of potentially inappropriate medications - EU (7)-PIM List...
June 15, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29932846/practical-assessment-and-management-of-vulnerabilities-in-older-patients-receiving-chemotherapy-asco-guideline-for-geriatric-oncology-summary
#4
Supriya G Mohile, William Dale, Mark R Somerfield, Arti Hurria
No abstract text is available yet for this article.
June 22, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29931793/safety-and-therapeutic-efficacy-of-mirabegron-25-mg-in-older-patients-with-overactive-bladder-and-multiple-comorbidities
#5
Yu Khun Lee, Hann-Chorng Kuo
AIM: The present study assessed the therapeutic efficacy and safety of mirabegron 25 mg in older patients aged ≥80 years with overactive bladder and multiple comorbidities. METHODS: Patients with overactive bladder were prospectively treated with 25 mg of mirabegron once daily. The patients were divided into a younger group (aged 40-60 years) and an older group (aged ≥80 years), and their underlying comorbidities were recorded. The primary efficacy end-point was the change in symptom score from baseline to the third month...
June 21, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29931746/neurological-and-psychological-changes-in-hemodialysis-patients-before-and-after-the-treatment
#6
Silvia Lai, Alessio Molfino, Oriano Mecarelli, Patrizia Pulitano, Santo Morabito, Valentina Pistolesi, Roberto Romanello, Alessia Zarabla, Alessandro Galani, Nicla Frassetti, Paola Aceto, Carlo Lai
Neurological, psychological, and cognitive disorders in chronic kidney disease may contribute to poor quality of life in these patients. The aim of this study was to assess the electroencephalographic, psychological, and cognitive changes before and after hemodialysis (HD) compared with healthy controls (HC). Sixteen HD patients and 15 HC were enrolled. Electroencephalogram (EEG), Minnesota multiphasic personality inventory (MMPI-2) Satisfaction profile (SAT-P), and Neuropsychological test Global z-scores (NPZ5) were performed before (T0) and after (T1) HD treatment and in HC...
June 22, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29928932/is-increased-neutrophil-lymphocyte-ratio-remarking-the-inflammation-in-sarcopenia
#7
Zeynel Abidin Öztürk, Seval Kul, İbrahim Halil Türkbeyler, Zeynel Abidin Sayıner, Azer Abiyev
OBJECTIVES: Increasing data suggests that chronic inflammation has an essential role on development of muscle dysfunction and progression of sarcopenia in aging population. The aim of the present study was to compare Neutrophil Lymphocyte Ratio (NLR) levels in sarcopenic and non-sarcopenic individuals and to present the correlation between NLR and other inflammatory markers. METHODS: A total of 105 subjects with sarcopenia (male/female: 54/51, mean age 72.8 ± 7...
June 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29927729/medication-management-in-older-adults-and-interprofessional-education-a-needs-assessment
#8
Tia Kostas, Randall Knoebel, Stacie Levine
Elderly, multi-morbid patients are at high risk for suffering adverse drug events. Safe medication management is a key process in preventing these adverse events, and requires interprofessional teamwork. We performed a needs assessment survey of graduating medical students and faculty to evaluate student training in medication management, in particular students' preparedness in the three minimum geriatrics competencies pertaining to medication management, interprofessional educational opportunities, and optimal learning methods...
June 21, 2018: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/29923530/a-study-on-prevalence-of-depression-and-associated-risk-factors-among-elderly-in-a-rural-block-of-tamil-nadu
#9
M Buvneshkumar, K R John, M Logaraj
Background: Depression among elderly is an important public health problem responsible for considerable morbidity and disability. Causes of depression are multifactorial and often preventable. As there was dearth of community studies in Tamil Nadu, the present study was undertaken. Objectives: The objective of this study is to estimate the prevalence of depression and to assess the factors which are associated with depression among elderly. Methods: A cross-sectional study was done from July 2014 to July 2015 among elderly in Kattankulathur block with a sample size of 690 by cluster sampling method...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29923472/the-ad8-dementia-screening-interview-is-a-valid-and-reliable-screening-scale-not-only-for-dementia-but-also-for-mild-cognitive-impairment-in-the-turkish-geriatric-outpatients
#10
Cansu Usarel, Ozge Dokuzlar, Ali Ekrem Aydin, Pinar Soysal, Ahmet Turan Isik
ABSTRACTIntroduction:There is still a need for short, practical, and daily-appropriate scales to distinguish between normal cognitive aging, mild cognitive impairment (MCI), or dementia for patients with memory complaints. This study aimed to determine validity and reliability of AD8 (Dementia Screening Interview) to detect both MCI and dementia in Turkish geriatric outpatients. METHODS: Comprehensive geriatric assessment was performed in 334 patients, who attended with their informants to the geriatric outpatient clinic for memory complaints...
June 20, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29922046/usual-gait-speed-is-associated-with-frailty-status-institutionalization-and-mortality-in-community-dwelling-rural-older-adults-a-longitudinal-analysis-of-the-aging-study-of-pyeongchang-rural-area
#11
Hee-Won Jung, Il-Young Jang, Chang Ki Lee, Sang Soo Yu, Jae Kyoon Hwang, Chawoong Jeon, Young Soo Lee, Eunju Lee
Purpose: We aimed to describe the age- and sex-specific distributions of gait speed and to evaluate associations with longitudinal outcomes in Korean rural community-dwelling older adults. Patients and methods: A total of 1,348 people (mean age: 76 years, 55% women) in the population-based, prospective cohort of Aging Study of Pyeongchang Rural Area (ASPRA) between October 2014 and June 2017. All participants underwent a comprehensive geriatric assessment, including 4-m usual gait speed, and were followed annually...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29921540/poor-nutritional-status-among-low-income-older-adults-examining-the-interconnection-between-self-care-capacity-food-insecurity-and-depression
#12
Seung Eun Jung, Seoyoun Kim, Alex Bishop, Janice Hermann
BACKGROUND: Understanding of the mechanisms of how food insecurity and poor physical and mental health status are interrelated with nutritional status among older adults is needed due to their unique health and social needs. OBJECTIVE: To examine the complex relationships between self-care capacity, depressive symptoms, food insecurity, and nutritional status among low-income older adults. DESIGN: The cross-sectional study was conducted from February 2017 to May 2017...
June 16, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29921533/orthogeriatric-co-management-managing-frailty-as-well-as-fragility
#13
Giulio Pioli, Chiara Bendini, Paolo Pignedoli, Andrea Giusti, David Marsh
A high proportion of patients with fragility fracture, mainly hip fracture, have a variable degree of comorbidity and show some degree of dependence in basic or more complex activities of daily living. Evaluating these patents following the geriatric concept of frailty, about one third of hip fracture patients may be categorised as frail with high risk of poor outcomes and prolonged length of stay, one third as not frail, and about one third with an intermediate condition. Due to the high vulnerability, combined with the hip fracture event and surgical repair procedures, a multidisciplinary approach that includes geriatric competencies becomes essential to improve short and long-term outcomes after hip fracture...
April 20, 2018: Injury
https://www.readbyqxmd.com/read/29916025/short-term-weight-loss-reverses-obesity-induced-microvascular-endothelial-dysfunction
#14
Tamas Csipo, Gabor A Fulop, Agnes Lipecz, Stefano Tarantini, Tamas Kiss, Priya Balasubramanian, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy
Obesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and exacerbates cognitive decline in aging...
June 18, 2018: GeroScience
https://www.readbyqxmd.com/read/29915736/evaluation-of-treatment-satisfaction-efficacy-and-safety-of-dipeptidyl-peptidase-4-inhibitors-in-geriatric-patients-with-type-2-diabetes-mellitus-a-cross-sectionalcomparative-study
#15
Harmanjit Singh, Avinash Chakrawarti, Harjit Singh, P Guruprasad, Yogendra Kumar Gupta
Introduction: Dipeptidyl peptidase 4 (DPP4) inhibitors are attractive agents to be used in the elderly patients with Type 2 diabetes mellitus (T2DM) because of their beneficial effects. Methods: In this cross-sectional, observational study, we evaluated and compared the treatment satisfaction using Diabetes Treatment Satisfaction Questionnaire (DTSQ) in two groups (i.e., regimens containing DPP4 inhibitors vs. other regimens). Efficacy was evaluated by assessing and comparing the glycosylated hemoglobin (HbA1c) values and the percentage of patients who achieved the glycemic control (HbA1c <7%)...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915439/%C3%AF-editors-choice%C3%AF-practice-management-for-elderly-patients-with-breast-cancer-findings-from-a-survey-by-the-japan-breast-cancer-study-group
#16
Masataka Sawaki, Kenji Tamura, Akihiko Shimomura, Yumiko Taki, Fumio Nagashima, Hiroji Iwata
Information on patterns of clinical care for elderly breast cancer patients is lacking. The aims of this study are two-fold, firstly, to clarify daily practice treatments for elderly breast cancer patients in Japan, and secondly, to plan a prospective clinical trial to address unresolved clinical questions. We investigated practice care of elderly breast cancer patients in 38 institutions of the Japan Clinical Oncology Group (JCOG). Questionnaires asked: (1) definition of "elderly" for each treatment, (2) clinical standard anti-HER2 therapy in each age-group, (3) recommended docetaxel dose in each age-group, (4) considerations for future clinical trials, and (5) other information about geriatric oncology concerning breast cancer...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914840/altered-body-composition-sarcopenia-frailty-and-their-clinico-biological-correlates-in-parkinson-s-disease
#17
Ai Huey Tan, Yin Cheng Hew, Shen-Yang Lim, Norlisah Mohd Ramli, Shahrul Bahyah Kamaruzzaman, Maw Pin Tan, Mathis Grossmann, Ban Hong Ang, Jiun Yan Tan, Mohamad Addin Azhan A Manap, Tun Khong Tay, Siang Lyn Tan, Ru Peng New, Farhana Fadzli, Eng Jui Yee, Foong Ming Moy, Sanjiv Mahadeva, Anthony E Lang
INTRODUCTION: Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention in PD. We studied body composition, sarcopenia, frailty, and their clinico-biological correlates in PD. METHODS: 93 patients and 78 spousal/sibling controls underwent comprehensive assessment of diet, clinical status, muscle strength/performance, frailty, body composition (using dual-energy X-ray absorptiometry), and serum levels of neurogastrointestinal hormones and inflammatory markers...
June 13, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29914306/nutritional-status-is-associated-with-the-degree-of-cognitive-impairment-and-depressive-symptoms-in-a-greek-elderly-population
#18
Mantzorou Maria, Vadikolias Konstantinos, Pavlidou Eleni, Serdari Aspasia, Vasios Georgios, Tryfonos Christina, Giaginis Constantinos
INTRODUCTION: Cognitive impairment and malnutrition are two important public health issues in the elderly, which have been associated with their mental health. AIMS: This study aims to evaluate the nutritional status of an elderly population in Greece, and its association with the grade of cognitive decline, anthropometric measures and psychological status. MATERIALS AND METHODS: A total of 2092 elderly men and women were enrolled from seven Greek cities...
June 19, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29910608/oral-health-related-quality-of-life-in-patients-undergoing-chronic-hemodialysis
#19
Ewa Rodakowska, Magdalena Wilczyńska-Borawska, Justyna Fryc, Joanna Baginska, Beata Naumnik
Aims: The aims of the study were to determine oral health-related quality of life (OHRQoL) in chronic hemodialysis (HD) patients and to estimate which scale describing OHRQoL, Oral Health Impact Profile (OHIP-14) or Geriatric/General Oral Health Assessment Index (GOHAI), was more useful in this particular group. Methods: This was a cross-sectional study conducted by means of a census survey. The Polish versions of OHIP-14 and GOHAI were used to assess OHRQoL. The oral examination included decayed, missing and filled teeth (DMF-T) Index; Oral Hygiene Index simplified; Plaque Index and Gingival Index...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29910184/effectiveness-of-the-timed-up-and-go-tug-and-the-chair-test-as-screening-tools-for-geriatric-fall-risk-assessment-in-the-ed
#20
Richard B Chow, Andre Lee, Bryan G Kane, Jeanne L Jacoby, Robert D Barraco, Stephen W Dusza, Matthew C Meyers, Marna Rayl Greenberg
OBJECTIVE: We sought to evaluate the effectiveness of the "Timed Up and Go" (TUG) and the Chair test as screening tools in the Emergency Department (ED), stratified by sex. METHODS: This prospective cohort study was conducted at a Level 1 Trauma center. After consent, subjects performed the TUG and the Chair test. Subjects were contacted for phone follow-up and asked to self-report interim falling. RESULTS: Data from 192 subjects were analyzed...
June 7, 2018: American Journal of Emergency Medicine
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