keyword
https://read.qxmd.com/read/38522361/endobronchial-silicone-spigot-in-prolonged-air-leaks-nationwide-study-on-outcomes-and-risk-factors-for-treatment-failure
#1
JOURNAL ARTICLE
Jumpei Taniguchi, Shotaro Aso, Jo Taisuke, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: The endobronchial silicone spigot, also known as the endobronchial Watanabe spigot, is used in bronchoscopic interventions to manage prolonged pulmonary air leakage. However, the outcomes of this procedure have not been thoroughly investigated. METHODS: Using a Japanese national inpatient database from April 2014 to March 2022, we assessed the clinical characteristics and outcomes of all eligible patients who received the endobronchial spigot. We also investigated risk factors associated with treatment failure...
March 23, 2024: Respiratory Investigation
https://read.qxmd.com/read/38512495/green-synthesis-of-silver-and-gold-nanoparticles-in-callistemon-viminalis-extracts-and-their-antimicrobial-activities
#2
JOURNAL ARTICLE
Shahid Khan, Abdur Rauf, Abdullah S M Aljohani, Yahya S Al-Awthan, Zubair Ahmad, Omar S Bahattab, Shehla Khan, Muhammad Saadiq, Shahid Ali Khan, Rekha Thiruvengadam, Muthu Thiruvengadam
In the current study, the bottlebrush [Callistemon viminalis (Sol. ex Gaertn.) G. Don] plant was selected for the green synthesis of silver (Ag) and gold (Au) nanoparticles and to evaluate its antibacterial and antifungal activities. Phytochemical screening of C. viminalis confirmed the presence of alkaloids, anthraquinones, saponins, tannins, betacyanins, phlobatanins, coumarins, terpenoids, steroids, glycosides, and proteins. To characterize the synthesized Ag and Au NPs, UV-Visible spectroscopy, FTIR spectroscopy for functional group identification, field emission scanning electron microscopy (FE-SEM) for particle size, and elemental analysis were performed using EDX...
March 21, 2024: Bioprocess and Biosystems Engineering
https://read.qxmd.com/read/38506028/-acute-and-chronic-rhinosinusitis-age-characteristics
#3
JOURNAL ARTICLE
S V Ryazantsev, I M Kirichenko, E L Savlevich, V I Popadyuk, N S Kozlova, A I Chernolev
Children's and adults' rhinosinusitis are two diseases that have both similarities and differences in anatomy, epidemiology, causes, pathogenesis, diagnosis and treatment. At the same rhinosinusitis is one of the most common in otorhinolaryngology's practice, both in children and adults. The of adults paranasal sinuses (PNS) anatomy differs from children's PNS anatomy. Although ostiomeatal complex occlusion is recognized as a major cause of poor ventilation and drainage of the adult paranasal sinuses, it does not have a strong effect on pediatric rhinosinusitis, but adenoids play a key role...
2024: Vestnik Otorinolaringologii
https://read.qxmd.com/read/38494809/-a-case-of-breast-cancer-that-developed-pulmonary-tumor-thrombotic-microangiopathy-during-adjuvant-chemotherapy
#4
JOURNAL ARTICLE
Kensuke Okano, Takahiro Suzuki, Atsumi Abe, Akiko Itaya, Yuma Kameyama, Shuntaro Matsumoto, Kenichi Hakamada
A 68-year-old woman underwent neoadjuvant chemotherapy for left breast cancer(triple negative type), cT2N3cM0, cStage ⅢC, and Bt+Ax(Ⅲ). The pathological diagnosis was ypT1aN2aM0, ypStage ⅢA, ER-, PgR-, HER2 score 1+, Ki- 67 25%. Adjuvant radiotherapy(50 Gy/25 Fr)was then administered, followed by capecitabine as adjuvant chemotherapy. Dyspnea occurred during administration of capecitabine, and computed tomography(CT)and blood test results suggested drug-induced interstitial pneumonia and disseminated intravascular coagulation(DIC)...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38487405/long-term-survival-following-medical-management-of-aspergillus-endocarditis-with-dissemination-as-a-consequence-of-steroid-therapy-in-severe-covid-19-pneumonia
#5
Kiran G Kulirankal, Ann Mary, Merlin Moni, Gopal S Pillai, Dipu T Sathyapalan
A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Despite the poor prognosis generally associated with fungal endocarditis, the patient survived following aggressive medical management with a combination of liposomal amphotericin b and voriconazole therapy and is now doing well for over two years and is off antifungal therapy for a year...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38481129/purulent-pericarditis-caused-by-methicillin-sensitive-staphylococcus-aureus-bacteriuria
#6
JOURNAL ARTICLE
Lorraine Mascarenhas, Dzhalal Agakishiev, Morgan Freeman, Scott Hubers
BACKGROUND: Purulent pericarditis (PP)- a purulent infection involving the pericardial space-requires a high index of suspicion for diagnosis as it often lacks characteristic signs of pericarditis and carries a mortality rate as high as 40% even with treatment. Common risk factors include immunosuppression, diabetes mellitus, thoracic surgery, malignancy, and uremia. Most reported cases of PP occur in individuals with predisposing risk factors, such as immunosuppression, and result from more commonly observed preceding infections, such as pneumonia, osteomyelitis, and meningitis...
March 13, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38479823/uptake-and-safety-of-pneumococcal-vaccination-in-adults-with-immune-mediated-inflammatory-diseases-a-uk-wide-observational-study
#7
JOURNAL ARTICLE
Georgina Nakafero, Matthew J Grainge, Tim Card, Christian D Mallen, Jonathan S Nguyen Van-Tam, Abhishek Abhishek
OBJECTIVE: The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association between vaccination and IMID flare. METHODS: Adults with IMIDs diagnosed on or before 01/09/2018, prescribed steroid-sparing drugs within the last 12 months and contributing data to the Clinical Practice Research Datalink Gold were included...
March 13, 2024: Rheumatology
https://read.qxmd.com/read/38470034/a-panel-of-janus-kinase-inhibitors-identified-with-anti-inflammatory-effects-protect-mice-from-lethal-influenza-virus-infection
#8
JOURNAL ARTICLE
Yang Yu, Si Chen, Haonan Zhang, Yuanyuan Duan, Zhuogang Li, Lefang Jiang, Weihua Cao, Qun Peng, Xulin Chen
Influenza remains a significant threat to public health. In severe cases, excessive inflammation can lead to severe pneumonia or acute respiratory distress syndrome, contributing to patient morbidity and mortality. While antivirals can be effective if administered early, current anti-inflammatory drugs have limited success in treating severe cases. Therefore, discovering new anti-inflammatory agents to inhibit influenza-related inflammatory diseases is crucial. Herein, we screened a drug library with known targets using a human monocyte U937 infected with the influenza virus to identify novel anti-inflammatory agents...
March 12, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38464245/biological-effects-of-corticosteroids-on-pneumococcal-pneumonia-in-mice-and-humans
#9
Hiroki Taenaka, Katherine D Wick, Aartik Sarma, Shotaro Matsumoto, Rajani Ghale, Xiaohui Fang, Mazharul Maishan, Jeffrey E Gotts, Charles R Langelier, Carolyn S Calfee, Michael A Matthay
Background: Streptococcus pneumoniae is the most common bacterial cause of community acquired pneumonia and the acute respiratory distress syndrome (ARDS). Some clinical trials have demonstrated a beneficial effect of corticosteroid therapy in community acquired pneumonia, COVID-19, and ARDS, but the mechanisms of this benefit remain unclear. The objective of this study was to investigate the effects of corticosteroids on the pulmonary biology of pneumococcal pneumonia in an observational cohort of mechanically ventilated patients and in a mouse model of bacterial pneumonia with Streptococcus pneumoniae ...
February 21, 2024: Research Square
https://read.qxmd.com/read/38457550/a-case-of-empty-sella-syndrome-with-adrenal-insufficiency-masked-by-prednisolone-after-administration-of-immune-checkpoint-inhibitors
#10
JOURNAL ARTICLE
Yuichiro Iwamoto, Fuminori Tatsumi, Mana Ohnishi, Yukino Katakura, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Hideaki Kaneto
INTRODUCTION: The use of immune checkpoint inhibitors (ICIs) is gradually increasing; ICIs produce a variety of immune-related adverse events (irAEs), especially ICI-induced hypoadrenocorticism, which can be a lethal complication if treatment is delayed. PATIENT CONCERNS: A 63-year-old man received chemotherapy with pembrolizumab for nonsmall cell lung cancer. He developed drug-induced interstitial pneumonia 366 days after receiving pembrolizumab and was treated with prednisolone...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38444994/methylphenidate-causes-chronic-eosinophilic-pneumonia
#11
Dhafer Alghamdi, Hamdan Jahdali, Abdullah Alharbi, Ahmad Alshehri, Bandar Alfirm, Hanaa Bamefleh
A man who is 38 years old and diagnosed with attention-deficit hyperactivity disorder was prescribed methylphenidate. Three weeks later, he began experiencing progressive shortness of breath and coughing. Imaging of his chest showed patchy bilateral ground-glass opacities, and bronchoscopy revealed a 15% eosinophil count in his bronchoalveolar lavage. A transbronchial biopsy confirmed a diagnosis of eosinophilic pneumonia. The patient's condition improved when he was given steroids and stopped taking methylphenidate...
2024: Annals of Thoracic Medicine
https://read.qxmd.com/read/38444989/corticosteroid-treatment-for-persistent-pulmonary-infiltrates-following-covid-19-infection-clearing-the-fog
#12
JOURNAL ARTICLE
Prince Ntiamoah, Michelle Biehl, Victoria Ruesch, Atul C Mehta, Samar Farha
BACKGROUND: Systemic corticosteroids have been shown to improve outcomes in severe coronavirus disease 2019 (COVID-19) pneumonia; however, their role in post-COVID-19 persistent lung abnormalities is not well defined. Here, we describe our experience with corticosteroids in patients with persistent lung infiltrates following COVID-19 infection. RESEARCH QUESTION: What is the efficacy of systemic corticosteroids in improving lung function and radiological abnormalities in patients following COVID-19 pneumonia? STUDY DESIGN AND METHODS: This is a single-center retrospective study evaluating patients with persistent respiratory symptoms and abnormal chest computed tomography findings...
2024: Annals of Thoracic Medicine
https://read.qxmd.com/read/38442129/antibacterial-activity-and-phytochemical-screening-of-traditional-medicinal-plants-most-preferred-for-treating-infectious-diseases-in-habru-district-north-wollo-zone-amhara-region-ethiopia
#13
JOURNAL ARTICLE
Mulugeta Alemu, Ermias Lulekal, Zemede Asfaw, Bikila Warkineh, Asfaw Debella, Abiy Abebe, Sileshi Degu, Eyob Debebe
Ethiopia's healthcare system relies on traditional medicinal practices that use medicinal plants to treat human and livestock ailments. However, the lack of empirical validation regarding the efficacy of these treatments against specific infectious diseases necessitates rigorous scientific investigations. The objective of this study was to investigate the antibacterial activity and phytochemical screening on five selected medicinal plant species, namely Solanum somalense Franchet., Verbascum sinaiticum Benth...
2024: PloS One
https://read.qxmd.com/read/38437683/acute-large-vessel-occlusion-due-to-an-infected-thrombus-formation-induced-by-invasive-sphenoid-sinus-aspergillosis-illustrative-case
#14
JOURNAL ARTICLE
Yoshiyasu Matsumoto, Yosuke Akamatsu, Koji Yoshida, Yasushi Ogasawara, Toshinari Misaki, Shunichi Sasou, Hiromu Konno, Kuniaki Ogasawara
BACKGROUND: The authors describe a rare case of acute large-vessel occlusion due to an infected thrombus formation that was induced by invasive sphenoid sinus aspergillosis. OBSERVATIONS: An 82-year-old man with a history of immunoglobulin G4-related disease and long-term use of steroids and immunosuppressants was admitted to the authors' hospital with severe right hemiparesis. Cerebral angiography revealed occlusion of the left internal carotid artery (ICA). He underwent thrombectomy, resulting in successful recanalization...
March 4, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38424575/human-herpesvirus-6-infection-in-a-critically-ill-and-immunocompetent-patient-a-case-report
#15
JOURNAL ARTICLE
Xin Tian Chia, Hai Liang Marc Wong, Jia Shen Loh
BACKGROUND: Human herpesvirus-6 is a rare infection in an immunocompetent adult. In existing literature, there is a dearth of knowledge that mainly exists as case reports and case series. CASE PRESENTATION: In this case report, we described a 29-year-old female of Myanmarese descent patient from Myanmar who presented with altered mental status and non-specific respiratory and gastrointestinal symptoms. She was initially treated for pneumonia and discharged well...
March 1, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38420060/deciphering-the-neuropsychiatric-lupus-enigma-navigating-the-intersection-of-acute-inflammatory-demyelinating-polyneuropathy-aidp-infection-and-flare
#16
Jhasaketan Meher, Jivtesh Singh, Saroj Kumar Pati, Vinay R Pandit, Saurabh K Patel, Mallika Kapur, M S Nithin
A 17-year-old male diagnosed with systemic lupus erythematosus (SLE), showing poor compliance with medication, presented to our facility with a 20-day history of fever, polyarthritis, and cough. Additionally, he had experienced a seizure episode, followed by a one-day history of altered mentation. Subsequently, he developed pneumonia, respiratory distress, and shock, necessitating ventilator and inotropic support. Neuropsychiatric lupus (NP-lupus) was suspected, and hence high-dose steroids, hydroxychloroquine, and broad-spectrum antibiotics were initiated...
January 2024: Curēus
https://read.qxmd.com/read/38419217/risk-factors-and-outcomes-of-upper-gastrointestinal-bleeding-in-hospitalized-patients-in-a-tertiary-care-hospital
#17
JOURNAL ARTICLE
Zahabia Muhammad Sohail Essani, Filza Naeem, Om Parkash
OBJECTIVE: To determine different aetiologies and outcomes of upper gastrointestinal bleeding in hospitalised patients. METHODS: The retrospective cohort study was conducted at the Aga Khan University Hospital, Karachi, and comprised data from December 2019 to April 2021 related to adult patients of either gender with nongastrointestinal illnesses who developed bleeding at least 24 hours after admission. Data was reviewed for clinical characteristics, cause of bleeding and clinical outcome...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38406079/pattern-and-predictors-of-infection-among-patients-with-rheumatological-disease-on-immunosuppressive-medications-a-retrospective-study-in-a-tertiary-care-hospital-in-bangladesh
#18
JOURNAL ARTICLE
S K Jakaria Been Sayeed, Md Moniruzzaman, A K M Humayon Kabir, Md Uzzwal Mallik, Bikas Chandra Mondal, Shahin Mahmud, Fahim T Rahman, Mehrin Rahman, Md Mujibur Rahman
Background Immunomodulatory therapy for chronic rheumatic disease carries a risk for infectious complications. In Bangladesh, there is limited information regarding patterns and factors associated with infections among patients receiving immunosuppressive medications. Objective The present study aimed to find out patterns and predictors associated with infection among patients who were on different immunosuppressive medications due to chronic rheumatological disease. Methodology This was a retrospective study; all confirmed cases of (new and old) different rheumatological diseases on disease-modifying agents attended at the rheumatology clinic of Dhaka Medical College Hospital from January 2019 to December 2021 were enrolled...
January 2024: Curēus
https://read.qxmd.com/read/38403765/autopsy-of-drug-induced-lung-injury-with-atypical-diffuse-alveolar-disorder-due-to-amiodarone-a-case-report
#19
JOURNAL ARTICLE
Hikaru Mamizu, Hiroki Kohda, Yuusuke Tomita, Takuma Hatakeyama, Maiko Mamizu, Daisuke Ishikawa, Hidenori Kawakami, Toshiki Furukawa, Takashi Ishida, Tsuyoshi Sakai
Amiodarone, a prominent antiarrhythmic drug, may cause lung injury. We herein report the case of an 87-year-old man who had been taking amiodarone for 5 years and was subsequently referred due to respiratory failure. Chest computed tomography revealed multiple consolidations with air bronchograms in both lungs. Despite administering steroid pulse therapy, his respiratory failure worsened, and he died 3 days later. Autopsy revealed hyaline membrane formation and organic formation with fibrin deposition. Drug-induced lung injury caused by amiodarone was confirmed by autopsy...
February 26, 2024: Internal Medicine
https://read.qxmd.com/read/38402465/opportunistic-pathogens-increased-and-probiotics-or-short-chain-fatty-acid-producing-bacteria-decreased-in-the-intestinal-microbiota-of-pneumonia-inpatients-during-sars-cov-2-omicron-variant-epidemic
#20
JOURNAL ARTICLE
Fan Huang, Min Luo, Jun Peng, Shide Liu, Jinlei He
The global pandemic of COVID-19 has been over four years, and the role of intestinal microbiota in the occurrence and development of COVID-19 needs to be further clarified. During the outbreak of SARS-CoV-2 Omicron variant in China, we analyzed the intestinal microbiome in fecal samples from inpatients with pneumonia and normal individuals in January 2023. The microbiota composition, alpha diversity, beta diversity, differential microbial community, co-occurrence networks, and functional abundance were analyzed...
March 1, 2024: Letters in Applied Microbiology
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