keyword
https://read.qxmd.com/read/37774434/radiosynthesis-preclinical-evaluation-and-pilot-clinical-pet-imaging-study-of-a-18-f-labeled-tracer-targeting-fibroblast-activation-protein
#21
JOURNAL ARTICLE
Lilan Fu, Jiawen Huang, Qingxing Liu, Fei Xie, Yanjiang Han, Penghui Sun, Min Cao, Yanchao Huang, Kongzhen Hu, Ganghua Tang
Fibroblast activation protein (FAP) is a promising molecular target for imaging in various types of cancers. Several 18 F-labeled FAP inhibitor (FAPI) tracers have been evaluated in clinical study. However, these tracers display high physiological uptake in gallbladder and bile duct system. To overcome the limitation, we herein designed a novel radiotracer named 18 F-FAPTG. 18 F-FAPTG was produced with a non-decay-corrected radiochemical yield of 24.0 ± 6.0% and 22.0 ± 7.0% for manual and automatic synthesis, respectively...
September 22, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/37747509/developmental-profiles-of-arithmetic-fluency-skills-from-grades-1-to-9-and-their-early-identification
#22
JOURNAL ARTICLE
Maria Psyridou, Minna Torppa, Asko Tolvanen, Anna-Maija Poikkeus, Marja-Kristiina Lerkkanen, Tuire Koponen
The aim of the present study was to examine the kinds of developmental profiles of arithmetic fluency skills that can be identified across Grades 1-9 (ages 7-16) in a large Finnish sample ( n = 2,518). The study also examined whether membership in the developmental profiles could be predicted using a comprehensive set of kindergarten-age factors, including information on cognitive skills; motivational, parental, and home environment factors; and gender. Four profiles of arithmetic fluency skills development were identified using a factor mixture model: persistent arithmetic difficulties (12...
September 25, 2023: Developmental Psychology
https://read.qxmd.com/read/37743718/integration-of-semi-empirical-ms-ms-library-with-characteristic-features-for-the-annotation-of-novel-amino-acid-conjugated-bile-acids
#23
JOURNAL ARTICLE
Yan Ma, Yang Cao, Xiaocui Song, Weichen Xu, Zichen Luo, Jinjun Shan, Jingjie Zhou
Recently, amino acids other than glycine and taurine were found to be conjugated with bile acids by the gut microbiome in mouse and human. As potential diagnostic markers for inflammatory bowel disease and farnesoid X receptor agonists, their physiological effects and mechanisms, however, remain to be elucidated. A tool for the rapid and comprehensive annotation of such new metabolites is required. Thus, we developed a semi-empirical MS/MS library for bile acids conjugated with 18 common amino acids, including alanine, arginine, asparagine, aspartate, glutamine, glutamate, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine...
September 25, 2023: Analyst
https://read.qxmd.com/read/37705705/oolong-tea-cultivars-categorization-and-germination-period-classification-based-on-multispectral-information
#24
JOURNAL ARTICLE
Qiong Cao, Chunjiang Zhao, Bingnan Bai, Jie Cai, Longyue Chen, Fan Wang, Bo Xu, Dandan Duan, Ping Jiang, Xiangyu Meng, Guijun Yang
Recognizing and identifying tea plant ( Camellia sinensis ) cultivar plays a significant role in tea planting and germplasm resource management, particularly for oolong tea. There is a wide range of high-quality oolong tea with diverse varieties of tea plants that are suitable for oolong tea production. The conventional method for identifying and confirming tea cultivars involves visual assessment. Machine learning and computer vision-based automatic classification methods offer efficient and non-invasive alternatives for rapid categorization...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37600965/executive-functions-and-morphological-awareness-explain-the-shared-variance-between-word-reading-and-listening-comprehension
#25
JOURNAL ARTICLE
Young-Suk Grace Kim
PURPOSE: A large body of literature showed that word reading and listening comprehension-two proximal predictors of reading comprehension according to the simple view of reading-are related. Grounded on the direct and indirect effects model of reading (Kim, 2020a, 2020b, 2023), we examined the extent to which the relation is explained by domain-general cognitions or executive functions (working memory and attentional control) and emergent literacy skills (language and code-related skills including morphological awareness, phonological awareness, orthographic pattern recognition, letter naming fluency, and rapid automatized naming)...
2023: Scientific Studies of Reading
https://read.qxmd.com/read/37600301/a-portable-system-for-economical-nucleic-acid-amplification-testing
#26
JOURNAL ARTICLE
Hui Dong, Jin Mo, Yongjian Yu, Wantao Xie, Jianping Zheng, Chao Jia
Introduction: Regular and rapid large-scale screening for pathogens is crucial for controlling pandemics like Coronavirus Disease 2019 (COVID-19). In this study, we present the development of a digital point-of-care testing (POCT) system utilizing microfluidic paper-based analytical devices (μPADs) for the detection of SARS-CoV-2 gene fragments. The system incorporates temperature tuning and fluorescent detection components, along with intelligent and autonomous image acquisition and self-recognition programs...
2023: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/37597408/epilepsynet-novel-automated-detection-of-epilepsy-using-transformer-model-with-eeg-signals-from-121-patient-population
#27
JOURNAL ARTICLE
Oh Shu Lih, V Jahmunah, Elizabeth Emma Palmer, Prabal D Barua, Sengul Dogan, Turker Tuncer, Salvador García, Filippo Molinari, U Rajendra Acharya
BACKGROUND: Epilepsy is one of the most common neurological conditions globally, and the fourth most common in the United States. Recurrent non-provoked seizures characterize it and have huge impacts on the quality of life and financial impacts for affected individuals. A rapid and accurate diagnosis is essential in order to instigate and monitor optimal treatments. There is also a compelling need for the accurate interpretation of epilepsy due to the current scarcity in neurologist diagnosticians and a global inequity in access and outcomes...
August 5, 2023: Computers in Biology and Medicine
https://read.qxmd.com/read/37592217/effects-of-a-developmental-dyslexia-remediation-protocol-based-on-the-training-of-audio-phonological-cognitive-processes-in-dyslexic-children-with-high-intellectual-potential-study-protocol-for-a-multiple-baseline-single-case-experimental-design
#28
JOURNAL ARTICLE
Gaëlle Darrot, Auriane Gros, Valeria Manera, Bruno De Cara, Sylvane Faure, Xavier Corveleyn, Karine Harrar-Eskinazi
BACKGROUND: The significant prevalence of children with high intellectual potential (HIP) in the school-age population and the high rate of comorbidity with learning disabilities such as dyslexia has increased the demand for speech and language therapy and made it more complex. However, the management of dyslexic patients with high intellectual potential (HIP-DD) is poorly referenced in the literature. A large majority of studies on HIP-DD children focus on the screening and diagnosis of developmental dyslexia, but only a few address remediation...
August 17, 2023: BMC Pediatrics
https://read.qxmd.com/read/37586201/integration-of-multi-omics-data-using-adaptive-graph-learning-and-attention-mechanism-for-patient-classification-and-biomarker-identification
#29
JOURNAL ARTICLE
Dong Ouyang, Yong Liang, Le Li, Ning Ai, Shanghui Lu, Mingkun Yu, Xiaoying Liu, Shengli Xie
With the rapid development and accumulation of high-throughput sequencing technology and omics data, many studies have conducted a more comprehensive understanding of human diseases from a multi-omics perspective. Meanwhile, graph-based methods have been widely used to process multi-omics data due to its powerful expressive ability. However, most existing graph-based methods utilize fixed graphs to learn sample embedding representations, which often leads to sub-optimal results. Furthermore, treating embedding representations of different omics equally usually cannot obtain more reasonable integrated information...
August 2, 2023: Computers in Biology and Medicine
https://read.qxmd.com/read/37571739/fccd-sar-a-lightweight-sar-atr-algorithm-based-on-fasternet
#30
JOURNAL ARTICLE
Xiang Dong, Dong Li, Jiandong Fang
In recent times, the realm of remote sensing has witnessed a remarkable surge in the area of deep learning, specifically in the domain of target recognition within synthetic aperture radar (SAR) images. However, prevailing deep learning models have often placed undue emphasis on network depth and width while disregarding the imperative requirement for a harmonious equilibrium between accuracy and speed. To address this concern, this paper presents FCCD-SAR, a SAR target recognition algorithm based on the lightweight FasterNet network...
August 5, 2023: Sensors
https://read.qxmd.com/read/37544251/capscnet-a-novel-scattering-network-for-automated-identification-of-phasic-cyclic-alternating-patterns-of-human-sleep-using-multivariate-eeg-signals
#31
JOURNAL ARTICLE
Manish Sharma, Sarv Verma, Divyansh Anand, Vikram M Gadre, U Rajendra Acharya
The Cyclic Alternating Pattern (CAP) can be considered a physiological marker of sleep instability. The CAP can examine various sleep-related disorders. Certain short events (A and B phases) manifest related to a specific physiological process or pathology during non-rapid eye movement (NREM) sleep. These phases unexpectedly modify EEG oscillations; hence, manual detection is challenging. Therefore, it is highly desirable to have an automated system for detecting the A-phases (AP). Deep convolution neural networks (CNN) have shown high performance in various healthcare applications...
July 14, 2023: Computers in Biology and Medicine
https://read.qxmd.com/read/37535807/auto-lectin-dotcoding-by-two-octopuses-rapid-analysis-of-fluorescence-labeled-glycoproteins-by-an-8-channel-fully-automatic-bead-array-scanner-with-a-rolling-circle-detector
#32
JOURNAL ARTICLE
Hiroko Shimazaki, Kazuhiro Nakamura, Ayaka Ono, Osamu Segawa, Kazumi Sawakami, Michinori Koizuka, Makoto Hirayama, Kanji Hori, Hideji Tajima, Atsushi Kuno
Protein glycosylation is a crucial factor that must be evaluated in biological pharmaceuticals. The glycoform profile of a protein can vary depending on the conditions of the cultivation, purification process, and the selection of a host cell. Lectin microarrays are reliable bioanalytical methods used in the early phases of bioprocesses for the detection of glycosylation. The concept of a fully automated glycan detection with a bead array has been previously reported; however, no simple system has been constructed on fluorescence-based detection using a microarray...
August 3, 2023: Analytical Chemistry
https://read.qxmd.com/read/37465984/progress-in-elementary-school-reading-linked-to-growth-of-cortical-responses-to-familiar-letter-combinations-within-visual-word-forms
#33
JOURNAL ARTICLE
Fang Wang, Blair Kaneshiro, Elizabeth Y Toomarian, Radhika S Gosavi, Lindsey R Hasak, Suanna Moron, Quynh Trang H Nguyen, Anthony M Norcia, Bruce D McCandliss
Learning to read depends on the ability to extract precise details of letter combinations, which convey critical information that distinguishes tens of thousands of visual word forms. To support fluent reading skill, one crucial neural developmental process is one's brain sensitivity to statistical constraints inherent in combining letters into visual word forms. To test this idea in early readers, we tracked the impact of two years of schooling on within-subject longitudinal changes in cortical responses to three different properties of words: coarse tuning for print, and fine tuning to either familiar letter combinations within visual word forms or whole word representations...
July 19, 2023: Developmental Science
https://read.qxmd.com/read/37463487/automated-synthesis-and-preclinical-evaluation-of-optimized-integrin-%C3%AE-6-targeted-positron-emission-tomography-imaging-of-pancreatic-cancer
#34
JOURNAL ARTICLE
Liping Chen, Haitian Fu, Huihui He, Kequan Lou, Qingbo Li, Jiacong Ye, Guokai Feng, Chunjing Yu
Integrin α6 has been considered a promising biomarker, is overexpressed in many tumors, and plays a vital role in tumor formation, recurrence, and metastasis. In this study, we identified a novel high-affinity integrin α6-targeted peptide named RD2 (Arg-Trp-Tyr-Asp-PEG4)2 -Lys-Lys and developed a 18 F-radiolabeled peptide tracer ([18 F]-AlF-NOTA-RD2 ) and evaluated its potential application in positron emission tomography (PET) imaging of pancreatic cancer. [18 F]-AlF-NOTA-RD2 was produced using GMP (Good Manufacturing Practice of Medical Products)-compliant automatic radiosynthesis on a single GE FASTLab2 cassette-type synthesis module...
July 18, 2023: Molecular Pharmaceutics
https://read.qxmd.com/read/37433651/how-active-coping-influences-school-aged-children-s-rapid-automatized-naming-a-chain-mediation-model-involving-subjective-vitality-and-aerobic-fitness
#35
JOURNAL ARTICLE
Jiajin Tong, Yundi Chen, Zhanjia Zhang, Xiujie Yang, Zhonghui He
Rapid automatized naming (RAN) has been proven to be important for students' academic performance, but it remains unclear whether and how dealing with stressors (e.g., active coping) is associated with children's development of RAN. To examine this question, this research views the growth of RAN as a cross-stressor adaptation process and proposes that school-aged children may build up adapted and modified stress response systems through active coping in dealing with stressors and cognitive tasks. Based on the broaden-and-build theory and the mind-body unity theory, we explored the impact of active coping on RAN and hypothesized that subjective vitality and aerobic fitness chain mediated the relationship between active coping and RAN...
July 11, 2023: PsyCh Journal
https://read.qxmd.com/read/37428367/visual-perception-and-linguistic-abilities-not-quantitative-knowledge-count-in-geometric-knowledge-of-kindergarten-children
#36
JOURNAL ARTICLE
Kaichun Liu, Xiaohan Huang, Xiujie Yang
Geometric knowledge is one of the important mathematical skills acquired by children at a young age and is a major area of future mathematical learning; however, there is no direct research on the factors influencing kindergarteners' early geometric knowledge. The pathways model to mathematics was modified to examine the cognitive mechanisms underlying geometric knowledge in Chinese kindergarten children aged 5-7 (n = 99). Quantitative knowledge, visual-spatial processing, and linguistic abilities were stepped into hierarchical multiple regression models...
July 10, 2023: Cognitive Processing
https://read.qxmd.com/read/37408955/ran-related-neural-congruency-a-machine-learning-approach-toward-the-study-of-the-neural-underpinnings-of-naming-speed
#37
JOURNAL ARTICLE
Christoforos Christoforou, Maria Theodorou, Argyro Fella, Timothy C Papadopoulos
OBJECTIVE: Naming speed, behaviorally measured via the serial Rapid automatized naming (RAN) test, is one of the most examined underlying cognitive factors of reading development and reading difficulties (RD). However, the unconstrained-reading format of serial RAN has made it challenging for traditional EEG analysis methods to extract neural components for studying the neural underpinnings of naming speed. The present study aims to explore a novel approach to isolate neural components during the serial RAN task that are (a) informative of group differences between children with dyslexia (DYS) and chronological age controls (CAC), (b) improve the power of analysis, and (c) are suitable for deciphering the neural underpinnings of naming speed...
2023: Frontiers in Psychology
https://read.qxmd.com/read/37387280/-simultaneous-determination-of-43-antibacterials-from-nine-categories-in-water-using-automatic-sample-loading-solid-phase-extraction-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#38
JOURNAL ARTICLE
Bao-Lin Xia, Shi-Tao Wang, Jing-Jing Yin, Wei-Yi Zhang, Na Yang, Qiang Liu, Hai-Jing Wu
Antibacterials represent a pharmaceutical class that is extensively used and consumed worldwide. The presence of a large number of antibacterial agents in water could result in antibiotic resistance. Thus, the development of a fast, accurate, and high-throughput method to analyze these emerging contaminants in water is necessary. Herein, a method was developed to achieve the simultaneous determination of 43 antibacterials from nine pharmaceutical categories (i.e., sulfonamides, quinolones, fluoroquinolones, tetracyclines, lincosamides, macrolides, nitroimidazoles, diterpenes, and dihydrofolate reductase inhibitors) in water using automatic sample loading-solid phase extraction (SPE)-ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
July 2023: Se Pu, Chinese Journal of Chromatography
https://read.qxmd.com/read/37371443/visual-motor-reaction-times-predict-receptive-and-expressive-language-development-in-early-school-age-children
#39
JOURNAL ARTICLE
Areej A Alhamdan, Melanie J Murphy, Sheila G Crewther
Proficiency of multisensory processing and motor skill are often associated with early cognitive, social, and language development. However, little research exists regarding the relationship between multisensory motor reaction times (MRTs) to auditory, visual and audiovisual stimuli, and classical measures of receptive language and expressive vocabulary development in school-age children. Thus, this study aimed to examine the concurrent development of performance in classical tests of receptive (Peabody Picture Vocabulary Test; abbreviated as PPVT) and expressive vocabulary (Expressive Vocabulary Test; abbreviated as EVT), nonverbal intelligence (NVIQ) (determined with the aid of Raven's Colored Progressive Matrices; abbreviated as RCPM), speed of visual-verbal processing in the Rapid Automatic Naming (RAN) test, Eye-Hand Co-ordination (EHC) in the SLURP task, and multisensory MRTs, in children ( n = 75), aged between 5 and 10 years...
June 19, 2023: Brain Sciences
https://read.qxmd.com/read/37362744/optimal-feature-selection-for-covid-19-detection-with-ct-images-enabled-by-metaheuristic-optimization-and-artificial-intelligence
#40
JOURNAL ARTICLE
Dattaprasad A Torse, Rajashri Khanai, Krishna Pai, Sridhar Iyer, Swati Mavinkattimath, Rakhee Kallimani, Salma Shahpur
There is a broad range of novel Coronaviruses (CoV) such as the common cold, cough, and severe lung infections. The mutation of this virus, which originally started as COVID-19 in Wuhan, China, has continued the rapid spread globally. As the mutated form of this virus spreads across the world, testing and screening procedures of patients have become tedious for healthcare departments in largely populated countries such as India. To diagnose COVID-19 pneumonia by radiological methods, high-resolution computed tomography (CT) of the chest has been considered the most precise method of examination...
March 20, 2023: Multimedia Tools and Applications
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