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https://www.readbyqxmd.com/read/28445366/biomechanical-integrity-in-craniofacial-surgery-calvarial-reconstruction-in-favorable-and-infected-defects-with-bone-morphogenetic-protein-2
#1
Zoe M MacIsaac, Sarah E Henderson, Sameer Shakir, Sanjay Naran, Darren M Smith, Liliana Camison, James J Cray, Alejandro J Almarza, Gregory M Cooper, Joseph E Losee
BACKGROUND: The limitations of autologous and alloplastic reconstruction for craniofacial bone defects have created a clinical need for viable tissue-engineering strategies. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has shown promise in this setting. The aim of this study was to determine the long-term biomechanical properties of rhBMP-2-mediated calvarial reconstruction. METHODS: Twelve-week-old New Zealand White rabbits underwent subtotal calvarectomy...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28441013/cytotoxicity-of-pyrazine-based-cyclometalated-c-n-pz-c-au-iii-carbene-complexes-impact-of-the-nature-of-the-ancillary-ligand-on-the-biological-properties
#2
Benoît Bertrand, Julio Fernandez-Cestau, Jesus Angulo, Marco M D Cominetti, Zoë A E Waller, Mark Searcey, Maria A O'Connell, Manfred Bochmann
The synthesis of a series of cyclometalated gold(III) complexes supported by pyrazine-based (C^N^C)-type pincer ligands is reported, including the crystal structure of a cationic example. The compounds provide a new platform for the study of antiproliferative properties of gold(III) complexes. Seven complexes were tested: the neutral series (C^N(pz)^C)AuX [X = Cl (1), 6-thioguanine (4), C≡CPh (5), SPh (6)] and an ionic series that included the N-methyl complex [(C^N(pzMe)^C)AuCl]BF4 (7) and the N-heterocyclic carbene complexes [(C^N(pz)^C)AuL](+) with L = 1,3-dimethylbenzimidazol-2-ylidene (2) or 1,3,7,9-tetramethylxanthin-8-ylidene (3)...
April 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28440866/a-prospective-comparison-of-how-the-level-of-response-to-alcohol-and-impulsivity-relate-to-future-dsm-iv-alcohol-problems-in-the-coga-youth-panel
#3
Marc A Schuckit, Tom L Smith, George Danko, Robert Anthenelli, Lara Schoen, Mari Kawamura, John Kramer, Danielle M Dick, Zoe Neale, Samuel Kuperman, Vivia McCutcheon, Andrey P Anokhin, Victor Hesselbrock, Michie Hesselbrock, Kathleen Bucholz
BACKGROUND: Alcohol problems reflect both environmental and genetic characteristics that often operate through endophenotypes like low levels of response (low LRs) to alcohol and higher impulsivity. Relationships of these preexisting characteristics to alcohol problems have been studied, but few analyses have included both low LR and impulsivity in the same model. METHODS: We extracted prospective data from 1,028 participants in the Prospective Youth Sample of the Collaborative Study for the Genetics of Alcoholism (COGA)...
April 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28438557/the-isozyme-selective-phosphodiesterase-4-inhibitor-abi-4-attenuates-the-effects-of-lipopolysaccharide-in-human-cells-and-rodent-models-of-peripheral-and-cns-inflammation
#4
Joseph R Hedde, Ashley N Hanks, Christopher J Schmidt, Zoë A Hughes
Inhibitors of phosphodiesterase-4 (PDE4) have been approved for the treatment of inflammatory disorders, but are associated with dose-limiting nausea and vomiting. These side effects are hypothesized to be mediated by inhibition of the PDE4D isozyme. Here we demonstrate the anti-inflammatory effects of the novel brain penetrant PDE4D-sparing PDE4 inhibitor, ABI-4. ABI-4 was a potent (EC50 ∼14 nM) inhibitor of lipopolysaccharide (LPS) induced TNF-α release from mouse microglia and human PBMCs. ABI-4 (0.32 mg/kg) blocked LPS-induced release of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in blood and brain of mice...
April 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28438482/manufacture-and-preparation-of-human-placenta-derived-mesenchymal-stromal-cells-for-local-tissue-delivery
#5
Lee Lankford, Y Julia Chen, Zoe Saenz, Priyadarsini Kumar, Connor Long, Diana Farmer, Aijun Wang
BACKGROUND: In this study we describe the development of a Current Good Manufacturing Practice (CGMP)-compliant process to isolate, expand and bank placenta-derived mesenchymal stromal cells (PMSCs) for use as stem cell therapy. We characterize the viability, proliferation and neuroprotective secretory profile of PMSCs seeded on clinical-grade porcine small intestine submucosa extracellular matrix (SIS-ECM; Cook Biotech). METHODS: PMSCs were isolated from early gestation placenta chorionic villus tissue via explant culture...
April 21, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28435310/tropical-diseases-of-the-myocardium-a-review
#6
REVIEW
Zoe C Groom, Aristotle D Protopapas, Vasileios Zochios
Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including Trypanosoma cruzi, the protozoal causative agent of American trypanosomiasis (Chagas disease), and Taenia solium, the cestode causative agent of taeniasis and cysticercosis. We also discuss tropical endomyocardial fibrosis, trichinellosis and schistosomiasis...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28434794/behavioral-and-physiological-responses-of-yellow-perch-perca-flavescens-to-moderate-hypoxia
#7
L Zoe Almeida, Samuel C Guffey, Maria S Sepúlveda, Tomas O Höök
While severe hypoxia can be lethal and is usually avoided by mobile aquatic organisms, moderate hypoxic conditions are likely more prevalent and may affect organisms, such as fishes, in a variety of systems. However, fishes have the potential to adjust physiologically and behaviorally and thus reduce the negative effects of hypoxia. Quantifying such physiological responses may shed light on the ability of fishes to tolerate reduced oxygen concentrations. This study assessed how two different hatchery populations of yellow perch Perca flavescens, a fish that is likely to encounter moderate hypoxic conditions in a variety of systems, responded to moderate hypoxic exposure through three experiments: 1) a behavioral foraging experiment, 2) an acute exposure experiment, and 3) a chronic exposure experiment...
April 18, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28434429/association-between-sleep-disordered-breathing-and-nighttime-driving-performance-in-mild-cognitive-impairment
#8
Nathan Cross, Zoe Terpening, Shantel L Duffy, Simon J G Lewis, Ron Grunstein, Keith Wong, Sharon L Naismith
OBJECTIVES: The effect of sleep disordered breathing (SDB) on driving performance in older adults has not been extensively investigated, especially in those with mild cognitive impairment (MCI). The aim of this study was to examine the relationship between severity measures of SDB and a simulated driving task in older adults with and without MCI. METHODS: Nineteen older adults (age ≥50) meeting criteria for MCI and 23 age-matched cognitively intact controls underwent neuropsychological assessment and a driving simulator task in the evening before a diagnostic sleep study...
April 24, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28433239/shame-feeling-in-the-intensive-care-unit-patient-s-family-members
#9
Vasilios Koulouras, Zoe Konstanti, Dimitra Lepida, Georgios Papathanakos, Mary Gouva
OBJECTIVE: To investigate the levels of internal and external shame among family members of critically ill patients. RESEARCH METHODOLOGY/ DESIGN: This prospective study was conducted in 2012/2013 on family members of Intensive Care Unit patients using the Others As Shamer Scale and the Experiential Shame Scale questionnaires. SETTING: Greek university hospital. RESULTS: Two hundred and twenty-three family members mean-aged (41...
April 19, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28432711/vdr-gene-methylation-as-a-molecular-adaption-to-light-exposure-historic-recent-and-genetic-influences
#10
Emma L Beckett, Patrice Jones, Martin Veysey, Konsta Duesing, Charlotte Martin, John Furst, Zoe Yates, Nina G Jablonski, George Chaplin, Mark Lucock
OBJECTIVES: The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects. METHODS: Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP. RESULTS: Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation (r(2)  = 0...
April 22, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28431533/effect-of-a-16-week-bikram-yoga-program-on-heart-rate-variability-and-associated-cardiovascular-disease-risk-factors-in-stressed-and-sedentary-adults-a-randomized-controlled-trial
#11
Zoe L Hewett, Kate L Pumpa, Caroline A Smith, Paul P Fahey, Birinder S Cheema
BACKGROUND: Chronic activation of the stress-response can contribute to cardiovascular disease risk, particularly in sedentary individuals. This study investigated the effect of a Bikram yoga intervention on the high frequency power component of heart rate variability (HRV) and associated cardiovascular disease (CVD) risk factors (i.e. additional domains of HRV, hemodynamic, hematologic, anthropometric and body composition outcome measures) in stressed and sedentary adults. METHODS: Eligible adults were randomized to an experimental group (n = 29) or a no treatment control group (n = 34)...
April 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28430459/direct-observation-of-percolation-in-the-yielding-transition-of-colloidal-glasses
#12
Antina Ghosh, Zoe Budrikis, Vijayakumar Chikkadi, Alessandro L Sellerio, Stefano Zapperi, Peter Schall
When strained beyond the linear regime, soft colloidal glasses yield to steady-state plastic flow in a way that is similar to the deformation of conventional amorphous solids. Because of the much larger size of the colloidal particles with respect to the atoms comprising an amorphous solid, colloidal glasses allow us to obtain microscopic insight into the nature of the yielding transition, as we illustrate here combining experiments, atomistic simulations, and mesoscopic modeling. Our results unanimously show growing clusters of nonaffine deformation percolating at yielding...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28429725/estrogen-reprograms-the-activity-of-neutrophils-to-foster-protumoral-microenvironment-during-mammary-involution
#13
Hwa Hwa Chung, Yu Zuan Or, Smeeta Shrestha, Jia Tong Loh, Chew Leng Lim, Zoe Ong, Amanda Rui En Woo, I-Hsin Su, Valerie C L Lin
Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast cancer. We report here that estrogen exacerbates mammary inflammation during involution. Microarray analysis shows that estrogen induces an extensive proinflammatory gene signature in the involuting mammary tissue. This is associated with estrogen-induced neutrophil infiltration. Furthermore, estrogen induces the expression of protumoral cytokines/chemokines, COX-2 and tissue-remodeling enzymes in isolated mammary neutrophils and systemic neutrophil depletion abolished estrogen-induced expression of these genes in mammary tissue...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28422129/gaas1-xbix-ganyas1-y-type-ii-quantum-wells-novel-strain-balanced-heterostructures-for-gaas-based-near-and-mid-infrared-photonics
#14
Christopher A Broderick, Shirong Jin, Igor P Marko, Konstanze Hild, Peter Ludewig, Zoe L Bushell, Wolfgang Stolz, Judy M Rorison, Eoin P O'Reilly, Kerstin Volz, Stephen J Sweeney
The potential to extend the emission wavelength of photonic devices further into the near- and mid-infrared via pseudomorphic growth on conventional GaAs substrates is appealing for a number of communications and sensing applications. We present a new class of GaAs-based quantum well (QW) heterostructure that exploits the unusual impact of Bi and N on the GaAs band structure to produce type-II QWs having long emission wavelengths with little or no net strain relative to GaAs, while also providing control over important laser loss processes...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421095/exploiting-wild-relatives-for-genomics-assisted-breeding-of-perennial-crops
#15
REVIEW
Zoë Migicovsky, Sean Myles
Perennial crops are vital contributors to global food production and nutrition. However, the breeding of new perennial crops is an expensive and time-consuming process due to the large size and lengthy juvenile phase of many species. Genomics provides a valuable tool for improving the efficiency of breeding by allowing progeny possessing a trait of interest to be selected at the seed or seedling stage through marker-assisted selection (MAS). The benefits of MAS to a breeder are greatest when the targeted species takes a long time to reach maturity and is expensive to grow and maintain...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28420446/immune-resistance-and-tolerance-strategies-in-malaria-vector-and-non-vector-mosquitoes
#16
Tibebu Habtewold, Zoe Groom, George K Christophides
BACKGROUND: The Anopheles gambiae complex consists of species that vary greatly in their capacity to transmit malaria. The mosquito immune system has been identified as a key factor that can influence whether Plasmodium infection establishes within the mosquito vector. This study was designed to investigate the immune responses of An. coluzzii, An. arabiensis and An. quadriannulatus mosquitoes. The first two mosquito species are major vectors of malaria in sub-Saharan Africa, while the third is thought to be a non-vector...
April 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28420363/context-matters-sources-of-variability-in-weekend-physical-activity-among-families-a-repeated-measures-study
#17
Robert J Noonan, Stuart J Fairclough, Zoe R Knowles, Lynne M Boddy
BACKGROUND: Family involvement is an essential component of effective physical activity (PA) interventions in children. However, little is known about the PA levels and characteristics of PA among families. This study used a repeated measures design and multiple data sources to explore the variability and characteristics of weekend PA among families. METHODS: Families (including a 'target' child aged 9-11 years, their primary caregiver(s) and siblings aged 6-8 years) were recruited through primary schools in Liverpool, UK...
April 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28419697/defensive-high-anxious-individuals-demonstrate-different-responses-to-pain-management-to-those-with-lower-levels-of-defensiveness-and-anxiety
#18
Zoe C Franklin, Neil E Fowler
OBJECTIVES: Few studies have considered the effect of Weinberger et al.'s personality types on the management of pain. The aims of this study were to (i) identify whether the relationships between pain intensity, cognitive factors and disability at three and six months post baseline differs as a result of personality type; and (ii) identify whether personality type affects the likelihood of achieving a minimal clinical important change (MCIC) in pain intensity or disability at three and six months...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28419121/the-magnitude-of-ivacaftor-effects-on-fluid-secretion-via-r117h-cftr-channels-human-in-vivo-measurements
#19
Jessica E Char, Colleen Dunn, Zoe Davies, Carlos Milla, Richard B Moss, Jeffrey J Wine
We optically measured effects of orally available ivacaftor (Kalydeco®) on sweat rates of identified glands in 3 R117H subjects, each having a unique set of additional mutations, and compared them with 5 healthy control subjects tested contemporaneously. We injected β-adrenergic agonists intradermally to stimulate CFTR-dependent 'C-sweat' and methacholine to stimulate 'M-sweat', which persists in CF subjects. We focused on an R117H-7T/F508del subject who produced quantifiable C-sweat off ivacaftor and was available for 1 blinded, 3 off ivacaftor, and 3 on ivacaftor tests, allowing us to estimate in vivo fold-increase in sweat rates produced by ivacaftor's effect on the open probability (PO) of R117H-CFTR...
2017: PloS One
https://www.readbyqxmd.com/read/28416667/autonomous-sweat-extraction-and-analysis-applied-to-cystic-fibrosis-and-glucose-monitoring-using-a-fully-integrated-wearable-platform
#20
Sam Emaminejad, Wei Gao, Eric Wu, Zoe A Davies, Hnin Yin Yin Nyein, Samyuktha Challa, Sean P Ryan, Hossain M Fahad, Kevin Chen, Ziba Shahpar, Salmonn Talebi, Carlos Milla, Ali Javey, Ronald W Davis
Perspiration-based wearable biosensors facilitate continuous monitoring of individuals' health states with real-time and molecular-level insight. The inherent inaccessibility of sweat in sedentary individuals in large volume (≥10 µL) for on-demand and in situ analysis has limited our ability to capitalize on this noninvasive and rich source of information. A wearable and miniaturized iontophoresis interface is an excellent solution to overcome this barrier. The iontophoresis process involves delivery of stimulating agonists to the sweat glands with the aid of an electrical current...
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
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