keyword
https://read.qxmd.com/read/38217069/a-novel-scoring-system-for-humane-endpoints-in-mice-with-cecal-ligation-and-puncture-induced-sepsis
#1
JOURNAL ARTICLE
Lindsey T Ferguson, Ammar A Rashied, Zhe Liang, Tetsuya Yumoto, Jerome C Anyalebechi, David A Swift, Marina S Hernandes, Robert T Krafty, Craig M Coopersmith, Vanessa K Lee
Animal-based research is essential to the study of sepsis pathophysiology, diagnostics, and therapeutics. However, animal models of sepsis are often associated with high mortality because of the difficulty in predicting imminent death based on premortem assessment of the animals. The use of validated visual scoring would allow researchers to systematically identify humane endpoints but visual approaches require high interobserver agreement for accurate results. The objective of this study was to establish a scoring system for mice undergoing cecal ligation and puncture (CLP)-induced sepsis based on 3 visual parameters: respiratory status, activity and response to stimulus (ASR), and eye appearance, with scores ranging from 0 to 3...
December 1, 2023: Comparative Medicine
https://read.qxmd.com/read/38206414/macular-dystrophy-in-kabuki-syndrome-due-to-de-novo-kmt2d-variants-refining-the-phenotype-with-multimodal-imaging-and-follow-up-over-10-years-insight-into-pathophysiology
#2
JOURNAL ARTICLE
Veronika Vaclavik, Aurelie Navarro, Alain Jacot-Guillarmod, Armand Bottani, Young Joo Sun, Joel A Franco, Vinit B Mahajan, Vasily Smirnov, Isabelle Bouvet-Drumare
BACKGROUND: Kabuki Syndrome is a rare and genetically heterogenous condition with both ophthalmic and systemic complications and typical facial features. We detail the macular phenotype in two unrelated patients with Kabuki syndrome due to de novo nonsense variants in KMT2D, one novel. A follow-up of 10 years is reported. Pathogenicity of both de novo nonsense variants is analyzed. METHODS: Four eyes of two young patients were studied by full clinical examination, kinetic perimetry, short wavelength autofluorescence, full field (ff) ERGs, and spectral-domain optical coherence tomography (SD-OCT)...
January 11, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38149058/advanced-workstations-and-collaborative-robots-exploiting-eye-tracking-and-cardiac-activity-indices-to-unveil-senior-workers-mental-workload-in-assembly-tasks
#3
JOURNAL ARTICLE
Patrik Pluchino, Gabriella F A Pernice, Federica Nenna, Michele Mingardi, Alice Bettelli, Davide Bacchin, Anna Spagnolli, Giulio Jacucci, Andrea Ragazzon, Leonardo Miglioranzi, Carlo Pettenon, Luciano Gamberini
Introduction: As a result of Industry 5.0's technological advancements, collaborative robots (cobots) have emerged as pivotal enablers for refining manufacturing processes while re-focusing on humans. However, the successful integration of these cutting-edge tools hinges on a better understanding of human factors when interacting with such new technologies, eventually fostering workers' trust and acceptance and promoting low-fatigue work. This study thus delves into the intricate dynamics of human-cobot interactions by adopting a human-centric view...
2023: Frontiers in Robotics and AI
https://read.qxmd.com/read/37809925/executive-functions-and-theory-of-mind-in-teachers-and-non-teachers
#4
JOURNAL ARTICLE
Paulo Barraza, Eugenio Rodríguez
Human teaching is a key behavior for the socialization of cultural knowledge. Previous studies suggest that human teaching behavior would support the development of executive and ToM skills, which in turn would refine the teaching behavior. Given this connection, it raises the question of whether subjects with professional training in teaching also have more efficient executive and ToM systems. To shed light on this issue, in the present study we compared the performance of professional teachers (N = 20, age range = 35-61 years) with a matched control group of non-teachers (N = 20, age range: 29-64 years) on tasks measuring working memory (Sternberg Task), cognitive flexibility (Wisconsin Card Sorting Test), executive control (Attention Network Test), along with online ToM skills (Frith-Happé Animations Task), emotion recognition (Reading the Mind in the Eyes Test) and first-order and second-order ToM (Yoni Task)...
September 2023: Heliyon
https://read.qxmd.com/read/37746418/preparation-of-soft-embalmed-cadavers-by-the-modified-thiel-embalming-technique-for-surgical-skill-training-and-development-of-a-universal-quantitative-scoring-system-to-assess-the-suitability-of-soft-embalmed-cadavers-for-such-training-purposes
#5
JOURNAL ARTICLE
Amrit G, Satyashree Ray, Soumyashree Mohapatra
Background Cadaver dissection plays an important role in learning anatomy. A surgeon must have a thorough knowledge of anatomy of the operating region to perform safe surgery. Skill laboratories give opportunities to surgeons to practice on cadavers before venturing onto real patients. The most common method of cadaver preservation is through formalin fixation. In the process of fixation, formalin destroys the tissue characteristics and also has issues such as smell, eye irritation, hardening of tissue, and risk of carcinogenesis...
August 2023: Curēus
https://read.qxmd.com/read/37483841/refining-the-diagnostic-technique-to-determine-prevalence-of-demodex-mites-in-eyelash-hair-follicles-within-standard-ophthalmic-practice-a-single-center-outpatient-clinical-study
#6
JOURNAL ARTICLE
Charlotte Boel, Elianne Westerveld, Daniëlla Kloos, Fleur Goezinne
PURPOSE: A high density of Demodex infestation in human eyelids and eyelash follicles has been implicated in a variety of ocular surface conditions. However, Demodex infestation often goes undiagnosed and untreated, due to an overlap in signs and symptoms with other sources of ocular surface inflammation. We sought to refine the diagnostic technique for outpatient assessment for Demodex infestation and determine prevalence of Demodex mites in the hair follicles of eyelashes from patients in a standard ophthalmic practice...
2023: Clinical Ophthalmology
https://read.qxmd.com/read/37306851/launching-your-vr-neuroscience-laboratory
#7
JOURNAL ARTICLE
Ying Choon Wu, Christopher Maymon, Jonathon Paden, Weichen Liu
The proliferation and refinement of affordable virtual reality (VR) technologies and wearable sensors have opened new frontiers in cognitive and behavioral neuroscience. This chapter offers a broad overview of VR for anyone interested in leveraging it as a research tool. In the first section, it examines the fundamental functionalities of VR and outlines important considerations that inform the development of immersive content that stimulates the senses. In the second section, the focus of the discussion shifts to the implementation of VR in the context of the neuroscience lab...
June 13, 2023: Current Topics in Behavioral Neurosciences
https://read.qxmd.com/read/37092391/feature-extraction-and-matching-of-humanoid-eye-binocular-images-based-on-susan-sift-algorithm
#8
JOURNAL ARTICLE
Xiaohua Xia, Haoming Xiang, Yusong Cao, Zhaokai Ge, Zainan Jiang
Imitating the visual characteristics of human eyes is one of the important tasks of digital image processing and computer vision. Feature correspondence of humanoid-eye binocular images is a prerequisite for obtaining the fused image. Human eyes are more sensitive to edge, because it contains much information. However, existing matching methods usually fail in producing enough edge corresponding pairs for humanoid-eye images because of viewpoint and view direction differences. To this end, we propose a novel and effective feature matching algorithm based on edge points...
March 29, 2023: Biomimetics
https://read.qxmd.com/read/36924515/-a-new-surgical-approach-to-pre-descemet-s-endothelial-keratoplasty
#9
JOURNAL ARTICLE
Yu Yu Kalinnikov, T H A Dinh, A V Zolotarevskiy, S Yu Kalinnikova
PURPOSE: The study aimed to develop new surgical methods of obtaining and preserving pre-Descemet's endothelial keratoplasty (PDEK) graft in order to reduce the loss of donor material. MATERIAL AND METHODS: The study was conducted on 30 sclerocorneal discs, which were divided into three groups. The first group consisted of 10 sclerocorneal discs to which the standard PDEK graft preparation technique was applied. The second group consisted of 10 sclerocorneal discs, where the PDEK graft preparation was done using the optimized method 1 involving the KD Ring fixator, KD Base for PDEK, KD-30G needle with 5 mL syringe connected to the spring-load plunger, a preservative solution...
2023: Vestnik Oftalmologii
https://read.qxmd.com/read/36812926/-recommendations-for-progressive-myopia-in-childhood-and-adolescence-statement-of-the-dog-bva-and-the-bielschowsky-society-for-strabismus-research-and-neuroophthalmology-status-june-2022
#10
JOURNAL ARTICLE
(no author information available yet)
Since the last and at the same time first statement of the German ophthalmological societies on the possibilities of reducing myopia progression in childhood and adolescence, many new details and aspects have emerged in clinical research. This second statement updates the previous document and specifies the recommendations on visual and reading behavior as well as on pharmacological and optical therapy options, which have been both refined and newly developed in the meantime.
February 2023: Klinische Monatsblätter Für Augenheilkunde
https://read.qxmd.com/read/36727342/impact-of-crossplay-between-ocular-aberrations-and-depth-of-focus-in-topo-guided-laser-assisted-in-situ-keratomileusis-outcomes
#11
COMMENT
Pooja Khamar, Rohit Shetty, Sriram Annavajjhala, Raghav Narasimhan, Savitri Kumari, Priyanka Sathe, Abhijit Sinha Roy
PURPOSE: To develop a nomogram in cases with mismatch between subjective and Topolyzer cylinder, and based on the magnitude of the mismatch, customize a treatment plan to attain good visual outcomes post-laser-assisted in situ keratomileusis (LASIK) surgery. METHODS: The patients were evaluated preoperatively using corneal tomography with Pentacam. Five optimal corneal topography scans were obtained from the Topolyzer Vario were used for planning the LASIK treatment...
February 2023: Indian Journal of Ophthalmology
https://read.qxmd.com/read/36369750/1p36-deletion-syndrome-review-and-mapping-with-further-characterization-of-the-phenotype-a-new-cohort-of-86-patients
#12
JOURNAL ARTICLE
Clémence Jacquin, Emilie Landais, Céline Poirsier, Alexandra Afenjar, Ahmad Akhavi, Nathalie Bednarek, Caroline Bénech, Adeline Bonnard, Damien Bosquet, Lydie Burglen, Patrick Callier, Sandra Chantot-Bastaraud, Christine Coubes, Charles Coutton, Bruno Delobel, Margaux Descharmes, Jean-Michel Dupont, Vincent Gatinois, Nicolas Gruchy, Sarah Guterman, Abdelkader Heddar, Lucas Herissant, Delphine Heron, Bertrand Isidor, Pauline Jaeger, Guillaume Jouret, Boris Keren, Paul Kuentz, Cedric Le Caignec, Jonathan Levy, Nathalie Lopez, Zoe Manssens, Dominique Martin-Coignard, Isabelle Marey, Cyril Mignot, Chantal Missirian, Céline Pebrel-Richard, Lucile Pinson, Jacques Puechberty, Sylvia Redon, Damien Sanlaville, Marta Spodenkiewicz, Anne-Claude Tabet, Alain Verloes, Gaelle Vieville, Catherine Yardin, François Vialard, Martine Doco-Fenzy
Chromosome 1p36 deletion syndrome (1p36DS) is one of the most common terminal deletion syndromes (incidence between 1/5000 and 1/10,000 live births in the American population), due to a heterozygous deletion of part of the short arm of chromosome 1. The 1p36DS is characterized by typical craniofacial features, developmental delay/intellectual disability, hypotonia, epilepsy, cardiomyopathy/congenital heart defect, brain abnormalities, hearing loss, eyes/vision problem, and short stature. The aim of our study was to (1) evaluate the incidence of the 1p36DS in the French population compared to 22q11...
November 11, 2022: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/36343205/assessing-associations-between-covid-19-symptomology-and-adverse-outcomes-after-piloting-crowdsourced-data-collection-a-cross-sectional-survey-study
#13
JOURNAL ARTICLE
Natalie Flaks-Manov, Jiawei Bai, Cindy Zhang, Anand Malpani, Stuart C Ray, Casey Overby Taylor
BACKGROUND: Crowdsourcing is a useful way to rapidly collect information on COVID-19 symptoms. There are potential biases and data quality issues that can be introduced, however, given the population that chooses to participate in crowdsourcing activities and common strategies used to screen participants based on their previous experience. OBJECTIVE: Study objectives were to: 1) build a pipeline to enable data quality and population representation checks in a pilot setting prior to deploying a final survey to a crowdsourcing platform, 2) assess COVID-19 symptomology among survey respondents that report a previous positive COVID-19 result, and 3) assess associations between symptomology groups and underlying chronic conditions and adverse outcomes due to COVID-19...
November 2, 2022: JMIR Formative Research
https://read.qxmd.com/read/36179000/in-defence-of-visual-analytics-systems-replies-to-critics
#14
JOURNAL ARTICLE
Aoyu Wu, Dazhen Deng, Furui Cheng, Yingcai Wu, Shixia Liu, Huamin Qu
The last decade has witnessed many visual analytics (VA) systems that make successful applications to wide-ranging domains like urban analytics and explainable AI. However, their research rigor and contributions have been extensively challenged within the visualization community. We come in defence of VA systems by contributing two interview studies for gathering critics and responses to those criticisms. First, we interview 24 researchers to collect criticisms the review comments on their VA work. Through an iterative coding and refinement process, the interview feedback is summarized into a list of 36 common criticisms...
September 30, 2022: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/35973683/update-on-biometry-and-lens-calculation-a-review-of-the-basic-principles-and-new-developments
#15
REVIEW
Jascha Wendelstein, Thomas Kohnen, Marina Casazza, Michael Heath, Kamran M Riaz, David L Cooke, Peter Hoffmann, Achim Langenbucher
These days, accurate calculation of artificial lenses is an important aspect of patient management. In addition to the classic theoretical optical formulae there are a number of new approaches, most of which are available as online calculators. This review aims to explain the background of artificial lens calculation and provide an update on study results based on the latest calculation approaches. Today, optical biometry provides the computational basis for theoretical optical formulae, ray tracing, and also empirical approaches using artificial intelligence...
August 2022: Klinische Monatsblätter Für Augenheilkunde
https://read.qxmd.com/read/35936272/horses-wait-for-more-and-better-rewards-in-a-delay-of-gratification-paradigm
#16
JOURNAL ARTICLE
Désirée Brucks, Anna Härterich, Uta König von Borstel
Self-control, defined as the ability to forgo immediate satisfaction in favor of better pay-offs in the future, has been extensively studied, revealing enormous variation between and within species. Horses are interesting in this regard because as a grazing species they are expected to show low self-control whereas its social complexity might be linked to high self-control abilities. Additionally, self-control may be a key factor in training and/or coping with potentially stressful husbandry conditions. We assessed horses' self-control abilities in a simplified delay of gratification test that can be easily implemented in a farm setting...
2022: Frontiers in Psychology
https://read.qxmd.com/read/35917084/comparison-of-formula-specific-factors-and-artificial-intelligence-formulas-with-axial-length-adjustments-in-bilateral-cataract-patients-with-long-axial-length
#17
JOURNAL ARTICLE
Chuang Li, Mingwei Wang, Rui Feng, Feiyan Liang, Xialin Liu, Chang He, Shuxin Fan
INTRODUCTION: To evaluate and compare the effectiveness for reducing the prediction error (PE) of the second eye using formula-specific factors, artificial intelligence (AI) formulas (PEARL-DGS and Kane), and the Cooke-modified axial length (CMAL) methods in bilateral cataract patients with long axial length (AL). METHODS: A total of 98 patients with long AL who underwent sequential bilateral cataract surgeries were retrospectively enrolled. The second-eye IOL power was calculated by the formula-specific factors, AI formulas, and CMAL methods when the first eye suffered from refraction surprise...
August 2, 2022: Ophthalmology and Therapy
https://read.qxmd.com/read/35858627/the-vision-correction-questionnaire-vcq-an-electronic-patient-reported-outcome-measure-for-refractive-surgery
#18
JOURNAL ARTICLE
Andreas Frings, Mohammed Ziaei, Mats Lundström, Bruce D Allan
PURPOSE: To develop a psychometrically robust electronic patient outcome measure (ePROM) for refractive surgery. SETTING: Moorfields Eye Hospital, London, United Kingdom. DESIGN: A questionnaire development study. METHODS: Items were derived in 6 domains (spectacle dependence, visual quality, eye comfort, functional freedom, emotional wellbeing, and satisfaction with treatment) from existing Rasch adjusted instruments, patient and surgeon feedback, and refinement in semi-structured interviews before administration to a field test cohort (n=360) of patients undergoing routine refractive surgery...
July 20, 2022: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/35849639/study-development-and-protocol-for-a-cohort-study-examining-the-impact-of-baseline-social-cognition-on-response-to-treatment-for-people-living-with-post-traumatic-stress-disorder
#19
JOURNAL ARTICLE
Chantelle Wiseman, Andrew D Lawrence, Jonathan I Bisson, James Hotham, Anke Karl, Stan Zammit
Background: Social cognitive impairments, specifically in facial emotion processing and mental state attribution, are common in post-traumatic stress disorder. However few studies so far have examined whether social cognitive ability impacts on PTSD recovery. Objective: To examine whether baseline social cognitive abilities are associated with treatment outcomes following trauma-focused therapy for PTSD. Method: This is a cohort study that will relate treatment outcomes post-discharge to baseline measures of social cognition (five tasks: Emotion Odd-One-Out Task (Oddity), Reading the Mind in the Eyes Task (RMET), Social Shapes Test (SST), Spontaneous Theory of Mind Protocol (STOMP), and Reflective Functioning Questionnaire (RFQ-8)) in people starting a course of psychological therapy for PTSD (target N  = 60)...
2022: European Journal of Psychotraumatology
https://read.qxmd.com/read/35714335/systematic-detection-of-keratoconus-in-oct-corneal-and-epithelial-thickness-maps
#20
JOURNAL ARTICLE
Burcu Yücekul, H Burkhard Dick, Suphi Taneri
PURPOSE: To detect keratoconus (KC) only by analyzing the corneal and epithelial map parameters and patterns in optical coherence tomography (OCT). SETTING: Tertiary care refractive surgery center. DESIGN: Retrospective data collection. METHODS: Corneal and epithelial thickness maps of normal, manifest, and subclinical keratoconic eyes (according to the Belin-Ambrosio display, Pentacam) were evaluated using spectral-domain OCT (Zeiss Cirrus 5000 HD)...
December 1, 2022: Journal of Cataract and Refractive Surgery
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