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Regadenoson

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https://www.readbyqxmd.com/read/29380204/cme-instructions-regadenoson-use-in-chronic-kidney-disease-and-end-stage-renal-disease-a-focused-review
#1
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29362983/detrimental-effects-of-nitroglycerin-use-during-regadenoson-vasodilator-stress-testing-a-cautionary-tale
#2
Vineet Agrawal, Carolann Hosey, Gary T Smith, Chirayu Shah
Vasodilator agents such as adenosine and regadenoson are commonly used pharmacologic stressors to assess for ischemia in patients undergoing myocardial perfusion studies. The recommended reversal agent for this mode of stress is aminophylline, although nitroglycerin is commonly administered as an attempt to reverse the symptoms or electrocardiographic (EKG) changes during the stress test. We demonstrate through two cases that incorrect administration of nitroglycerin can induce hypotension and worsen coronary steal, whereas appropriate administration of aminophylline can reverse the effects of pharmacologic vasodilators...
January 23, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29332604/the-effect-of-an-adenosine-a2a-agonist-on-intra-tumoral-concentrations-of-temozolomide-in-patients-with-recurrent-glioblastoma
#3
Sadhana Jackson, Jon Weingart, Edjah K Nduom, Thura T Harfi, Richard T George, Dorothea McAreavey, Xiaobu Ye, Nicole M Anders, Cody Peer, William D Figg, Mark Gilbert, Michelle A Rudek, Stuart A Grossman
BACKGROUND: The blood-brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study was conducted to evaluate if activation of A2A receptors would increase intra-tumoral temozolomide concentrations in patients with glioblastoma. METHODS: Patients scheduled for a clinically indicated surgery for recurrent glioblastoma were eligible...
January 15, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29297515/erratum-field-jj-majerus-e-gordeuk-vr-et-al-randomized-phase-2-trial-of-regadenoson-for-treatment-of-acute-vaso-occlusive-crises-in-sickle-cell-disease-blood-adv-2017-1-20-1645-1649
#4
(no author information available yet)
[This corrects the article DOI: 10.1182/bloodadvances.2017009613.].
October 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296811/randomized-phase-2-trial-of-regadenoson-for-treatment-of-acute-vaso-occlusive-crises-in-sickle-cell-disease
#5
Joshua J Field, Elaine Majerus, Victor R Gordeuk, Michel Gowhari, Carolyn Hoppe, Matthew M Heeney, Maureen Achebe, Alex George, Hillary Chu, Brian Sheehan, Maneka Puligandla, Donna Neuberg, Gene Lin, Joel Linden, David G Nathan
Adenosine A2A receptor (A2AR) agonists have been shown to decrease tissue inflammation induced by hypoxia/reoxygenation in mice with sickle cell disease (SCD). The key mediator of the A2AR agonist's anti-inflammatory effects is a minor lymphocyte subset, invariant natural killer T (iNKT) cells. We tested the hypothesis that administration of an A2AR agonist in patients with SCD would decrease iNKT cell activation and dampen the severity of vaso-occlusive (VO) crises. In a phase 2, randomized, placebo-controlled trial, we administered a 48-hour infusion of the A2AR agonist regadenoson (1...
September 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29273695/cardiac-displacement-during-13n-ammonia-myocardial-perfusion-pet-ct-comparison-between-adenosine-and-regadenoson-induced-stress
#6
Elise Vleeming, Sergiy Lazarenko, Friso van der Zant, Xiao-Bo Pan, Jerome Declerck, Maurits Wondergem, Remco Knol
PURPOSE: In this study, differences are investigated in cardiac displacement during adenosine stress versus regadenoson stress in 13N-Ammonia(13NH3) MP PET/CT scans. METHODS: A total of 61 MP PET/CTs were acquired using either adenosine (n=30) or regadenoson (n=31) as a stressor. For both groups, cardiac displacement during rest and stress was measured three-dimensionally, relative to either a fixed reference frame or the previous frame, in each 1-minute frame of a list-mode PET acquisition of 25 minutes...
December 22, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29244203/pediatric-tolerogenic-dcs-expressing-cd4-and-immunoglobulin-like-transcript-receptor-ilt-4-secrete-il-10-in-response-to-fc-and-adenosine
#7
Alessandra Franco, Jeetendra Kumar, Gene Lin, Negar Behnamfar, Li-En Hisieh, Chisato Shimizu, Adriana H Tremoulet, Jane C Burns, Joel Linden
We characterized a novel population of tolerogenic myeloid dendritic cells (tmDCs) defined as CD11c+ CD11b+ CD14+ CD4+ and immunoglobulin-like transcript receptor (ILT)-4+ that are significantly more abundant in the circulation of infants and young children than in adults. TmDCs secrete the immunosuppressive lymphokine interleukin (IL)-10 when stimulated with the heavy constant region of immunoglobulins (Fc) and express high levels of the adenosine A2A receptor (A2A R), which, when activated by adenosine, inhibits the release of pro-inflammatory cytokines from most immune cells...
December 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29202847/effects-of-adenosine-and-regadenoson-on-hemodynamics-measured-using-cardiovascular-magnetic-resonance-imaging
#8
Dustin M Thomas, Matthew R Minor, James K Aden, Christopher J Lisanti, Kevin E Steel
BACKGROUND: Adenosine or regadenoson vasodilator stress cardiovascular magnetic resonance (CMR) is an effective non-invasive strategy for evaluating symptomatic coronary artery disease. Vasodilator injection typically precedes ventricular functional sequences to efficiently reduce overall scanning times, though the effects of vasodilators on CMR-derived ventricular volumes and function are unknown. METHODS: We prospectively enrolled 25 healthy subjects to undergo consecutive adenosine and regadenoson administration...
December 4, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29184761/estimating-extraction-fraction-and-blood-flow-by-combining-first-pass-myocardial-perfusion-and-t1-mapping-results
#9
Devavrat Likhite, Promporn Suksaranjit, Ganesh Adluru, Brent Wilson, Edward DiBella
Background: Quantifying myocardial perfusion is complicated by the complexity of pharmacokinetic model being used and the reliability of perfusion parameter estimates. More complex modeling provides more information about the underlying physiology, but too many parameters in complex models introduce a new problem of reliable estimation. To overcome the problem of multiple parameters, we have developed a technique that combines knowledge from two different cardiac magnetic resonance (MR) imaging techniques: dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and T1 mapping...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29177261/performance-and-safety-profile-of-regadenoson-myocardial-perfusion-imaging-first-experience-in-greece
#10
John Koutsikos, George Angelidis, Athanasios Zafeirakis, Ioannis Mamarelis, Merkourios Vogiatzis, Eliverta Ilia, Kyriakos Lazaridis, Nikolaos Demakopoulos
OBJECTIVE: MPI can provide valuable information in the investigation of patients with known or suspected coronary artery disease. The stress component of the studies can be conducted with regadenoson, which was approved for clinical use in Greece in 2016. We investigated the performance and safety profile of regadenoson MPI based on our 7 months institutional experience. PATIENTS AND METHODS: We studied 96 consecutive patients (59 males, 37 females, mean age 70...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29043556/incidence-of-atrioventricular-block-with-vasodilator-stress-spect-a-meta-analysis
#11
Efstathia Andrikopoulou, Charity J Morgan, Lizbeth Brice, Navkaranbir S Bajaj, Harish Doppalapudi, Ami E Iskandrian, Fadi G Hage
BACKGROUND: Adenosine or regadenoson are often used with pharmacologic stress testing. Adenosine may trigger atrioventricular block (AVB). Despite its higher selectivity, regadenoson has also been associated with AVB. We studied the incidence of de novo AVB with these agents. METHODS: A comprehensive search of SCOPUS was performed from inception to March 2016. Studies of at least 10 patients, using adenosine and/or regadenoson with SPECT-MPI, reporting rates of AVB were selected for further review...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28956734/coronary-artery-disease-analysis-of-diagnostic-performance-of-ct-perfusion-and-mr-perfusion-imaging-in-comparison-with-quantitative-coronary-angiography-and-spect-multicenter-prospective-trial
#12
Matthias Rief, Marcus Y Chen, Andrea L Vavere, Benjamin Kendziora, Julie M Miller, W Patricia Bandettini, Christopher Cox, Richard T George, João Lima, Marcelo Di Carli, Michail Plotkin, Elke Zimmermann, Michael Laule, Peter Schlattmann, Andrew E Arai, Marc Dewey
Purpose To compare the diagnostic performance of stress myocardial computed tomography (CT) perfusion with that of stress myocardial magnetic resonance (MR) perfusion imaging in the detection of coronary artery disease (CAD). Materials and Methods All patients gave written informed consent prior to inclusion in this institutional review board-approved study. This two-center substudy of the prospective Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) multicenter trial included 92 patients (mean age, 63...
September 25, 2017: Radiology
https://www.readbyqxmd.com/read/28924814/the-prognostic-value-of-heart-rate-response-during-vasodilator-stress-myocardial-perfusion-imaging-in-patients-with-end-stage-renal-disease-undergoing-renal-transplantation
#13
Wael AlJaroudi, Chiedozie Anokwute, Ibtihaj Fughhi, Tania Campagnoli, Marwan Wassouf, Aviral Vij, Michael Kharouta, Andrew Appis, Amjad Ali, Rami Doukky
BACKGROUND: In asymptomatic end-stage renal disease (ESRD) patients undergoing vasodilator stress myocardial perfusion imaging (MPI) prior to renal transplantation (RT), the impact of pre-transplant heart rate response (HRR) to vasodilator stress on post-RT outcomes is unknown. METHODS: We analyzed a retrospective cohort of asymptomatic patients with ESRD who underwent a vasodilator stress SPECT-MPI and subsequently received RT. Blunted HRR was defined as HRR <28% for regadenoson stress and <20% for adenosine stress...
September 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28888873/comparison-of-regadenoson-and-nitroprusside-to-adenosine-for-measurement-of-fractional-flow-reserve-a-systematic-review-and-meta-analysis
#14
Justin Z Lee, Nirmal Singh, Iwan Nyotowidjojo, Carol Howe, See-Wei Low, Thach Nguyen, Duane Pinto, Gautam Kumar, Kwan S Lee
BACKGROUND: FFR is useful in defining the physiological significance of intermediate coronary stenosis and requires induction of maximal hyperemia and measurement of pressure proximal and distal to the stenosis. Hyperemia normally is induced by either IV or IC adenosine, a medication associated with short-term side effects. IV regadenoson and IC nitroprusside have been suggested as viable alternatives. This meta-analysis aims to identify all studies comparing use of intravenous (IV) regadenoson or intracoronary (IC) nitroprusside with IV adenosine to determine differences related to the agent utilized for assessment of fractional flow reserve (FFR)...
July 11, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28861743/feasibility-and-safety-of-exercise-stress-testing-using-an-anti-gravity-treadmill-with-tc-99m-tetrofosmin-single-photon-emission-computed-tomography-spect-myocardial-perfusion-imaging-a-pilot-non-randomized-controlled-study
#15
Patrick Daly, Regina Kayse, Steven Rudick, Nathan Robbins, Jennifer Scheler, David Harris, Robert O'Donnell, Alok K Dwivedi, Myron C Gerson
BACKGROUND: Exercise is the AHA/ACC guideline-recommended stress modality for myocardial perfusion imaging, but many patients are unable to exercise to target heart rate on a conventional treadmill. We examined the feasibility and safety of stress imaging using an anti-gravity treadmill in patients with perceived poor exercise capacity. METHODS AND RESULTS: 49 patients were recruited for stress testing by anti-gravity treadmill (n = 29) or to a regadenoson control group (n = 20)...
August 31, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28856613/the-heart-rate-response-to-regadenoson-in-patients-with-atrial-fibrillation
#16
Anezi I Uzendu, Ami Iskandrian, Fadi G Hage
No abstract text is available yet for this article.
August 30, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28808896/regadenoson-use-for-stress-myocardial-perfusion-imaging-in-advance-chronic-kidney-disease-and-dialysis-safe-effective-and-efficient
#17
EDITORIAL
Ankur Gupta, Navkaranbir S Bajaj
No abstract text is available yet for this article.
August 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28798245/regadenoson-cardiac-stress-test-induced-stress-cardiomyopathy
#18
Jagadeesh K Kalavakunta, Dominika M Zoltowska, Yashwant Agrawal, Vishal Gupta
Takotsubo cardiomyopathy, also described as apical ballooning syndrome/stress-induced cardiomyopathy, imitates acute coronary syndrome and is usually related to a massive physiological or emotional stressor. We describe perhaps the first reported case to the best of our knowledge of a 55-year-old Caucasian woman who presented with congestive heart failure after having a regadenoson cardiac stress test a few hours prior to presentation to the hospital. Transthoracic echocardiogram revealed reduced heart function...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28685008/stress-spect-myocardial-perfusion-imaging-in-end-stage-renal-disease
#19
Yasmeen Golzar, Rami Doukky
PURPOSE OF REVIEW: Patients with end-stage renal disease (ESRD) have an increased risk of cardiovascular morbidity and mortality. Cardiac risk assessment, though challenging, is critical in these high-risk patients, particularly in the pre-transplant population. In this review, we discuss the burden of coronary artery disease in the ESRD population and review the literature on the diagnostic and prognostic performance, clinical value, and future directions of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in ESRD patients...
May 2017: Current Cardiovascular Imaging Reports
https://www.readbyqxmd.com/read/28683710/-asystole-after-regadenoson-administration-to-perform-a-myocardial-perfusion-imaging-test
#20
Daniel Briegas Morera, Susana Martín Clavo, María José Estepa Alonso, Juan Francisco Rangel Mayoral
No abstract text is available yet for this article.
July 1, 2017: Farmacia Hospitalaria
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