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https://www.readbyqxmd.com/read/29902849/-application-of-mohs-microsurgery-in-nasal-basal-cell-carcinoma
#1
W Y Ma, W Liu, X Z Li, P Ye, L Q Zhang, X L Cai
Objective: To discuss the application of Mohs microsurgery in nasal and facial basal cell carcinoma (BCC) and analyze the pathological and clinical features. Methods: The clinical data of 127 patients who were diagnosed by pathology as nasal and facial BCC in Qilu Hospital of Shandong University from January 2010 to January 2015 were retrospectively analysed. The value of Mohs microsurgery was discussed and the nasal & facial sites of BCC lesions, clinical and histopathology features were summarized. Results: The proportion of male and female was 1...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29894525/perianal-basal-cell-carcinoma-treated-with-mohs-micrographic-surgery
#2
Michael Ryan, Hamad Alabdulrazzaq, Jennifer Toyohara
Perianal basal cell carcinoma (BCC) is a rare lesion that accounts for less than 0.08% of all BCCs. It is challenging to diagnose, as it can be overlooked or mistaken for an inflammatory dermatosis. When discovered early and treated properly, BCC is associated with low mortality and a good prognosis. Thorough total-body skin examinations and biopsy of suspected lesions found in the perianal region is recommended. We present a case of a superficial nodular perianal BCC that was discovered following a routine total-body skin examination and was treated with Mohs micrographic surgery (MMS)...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894522/mohs-micrographic-surgery-for-digital-melanoma-and-nonmelanoma-skin-cancers
#3
Zain Husain, Rina M Allawh, Ali Hendi
Treatment of digital skin cancers is challenging due to various functional and cosmetic implications. Traditionally, routine treatment includes radical amputation, but digital skin cancers are increasingly being treated with more conservative, tissue-sparing methods such as Mohs micrographic surgery (MMS), which provides excellent tissue conservation and margin control when used to treat melanoma and nonmelanoma skin cancers (NMSCs). In this study, we conducted a retrospective chart review to evaluate clinical outcomes following MMS for treatment of digital melanoma and NMSCs...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894433/eccrine-porocarcinoma-new-insights-and-a-systematic-review-of-the-literature
#4
Azadeh Nazemi, Shauna Higgins, Reyna Swift, Gino In, Kimberly Miller, Ashley Wysong
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE: To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS: A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines...
June 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29894432/a-predictive-model-for-primary-closure-lengths-in-mohs-surgery-based-on-skin-cancer-type-dimensions-and-location
#5
Zachary A Theroux, Adam B Blechman, Mark A Russell
BACKGROUND: Surgical scar length is a common concern among patients undergoing Mohs micrographic surgery (MMS). OBJECTIVE: This study evaluates 3 metrics of preoperative lesion size to determine which correlates best with primary linear closure lengths for nonmelanoma skin cancers (NMSCs) treated with MMS. This metric is then used to develop predictive models for linear closure lengths in 10 different anatomical regions. MATERIALS AND METHODS: A retrospective study of 4,049 NMSCs treated with MMS and repaired with primary linear closure was conducted...
June 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29890839/mohs-micrographic-surgery-dermatopathology-concordance-in-canada-a-single-institution-experience
#6
Justin C Chia, Marie S Abi Daoud, Tyler S Williamson, Habib A Kurwa
BACKGROUND: Mohs micrographic surgery (MMS) is a surgical modality that achieves high cure rates of nonmelanoma skin cancers but is dependent on accurate histologic examination of surgical margins. Therefore, quality assurance is essential to ongoing assessment of histological margins. OBJECTIVES: To prospectively determine the concordance rate between a Mohs surgeon (MS) and dermatopathologist (DP) with respect to tumour status (ie, present or absent) and tumour type...
June 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29889736/the-differential-use-of-bilobed-and-trilobed-transposition-flaps-in-cutaneous-nasal-reconstructive-surgery
#7
Thomas Knackstedt, Kachiu Lee, Nathaniel J Jellinek
BACKGROUND: Bilobed and trilobed transposition flaps are versatile random pattern transposition flaps which reliably restore nasal symmetry, topography, light reflex, contour and are frequently used in cutaneous nasal reconstructive surgery. We wish to compare the characteristics of bilobed and trilobed flaps in cutaneous reconstructive surgery and to identify scenarios for their differential use. METHODS: A retrospective chart review over 7 years of consecutive patients reconstructed with a bilobed or trilobed flap after Mohs micrographic surgery was performed...
May 22, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29888815/merkel-cell-polyomavirus-integration-pcr-in-bilateral-metachronous-merkel-cell-carcinoma-on-the-nose
#8
Susanne Hanner, Ulrike Wieland, Wolfgang Hartschuh, Alexander Enk, Ferdinand Toberer
An 81-year-old woman presented with a several weeks history of an erythematous tumour at her right nostril (Figure 1a). The tumour was surgically removed. Histopathology showed peritumoral clefts and BerEP4-expression consistent with basal cell carcinoma (Figure 2a). One year later the patient developed a small erythematous tumour at the left nostril (Figure 1b). Histopathology was consistent with a diagnosis of Merkel cell carcinoma (MCC) (Figure 2c,d). The tumour was removed using Mohs micrographic surgery...
June 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29866838/distinguishing-malignant-from-benign-microscopic-skin-lesions-using-desorption-electrospray-ionization-mass-spectrometry-imaging
#9
Katherine Margulis, Albert S Chiou, Sumaira Z Aasi, Robert J Tibshirani, Jean Y Tang, Richard N Zare
Detection of microscopic skin lesions presents a considerable challenge in diagnosing early-stage malignancies as well as in residual tumor interrogation after surgical intervention. In this study, we established the capability of desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to distinguish between micrometer-sized tumor aggregates of basal cell carcinoma (BCC), a common skin cancer, and normal human skin. We analyzed 86 human specimens collected during Mohs micrographic surgery for BCC to cross-examine spatial distributions of numerous lipids and metabolites in BCC aggregates versus adjacent skin...
June 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29860652/basal-cell-carcinoma-a-patient-and-physician-s-experience
#10
Barbara J Cohen, Eliahou S Cohen, Philip R Cohen
In this article, the first coauthor, a patient with a basal cell carcinoma on her upper lip, discusses her experience with Mohs micrographic surgery for the treatment of the skin cancer. The second coauthor, who is the patient's physician (a dermatologist who shares her last name but is not a relative), diagnosed her skin cancer and referred her for Mohs surgery. The third coauthor, who is the patient's son and not only a dermatologist, but also a dermatopathologist and a Mohs surgeon (and also shares her last name), summarizes the presentation and treatment of the basal cell carcinoma...
June 2, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29846341/patients-body-image-improves-after-mohs-micrographic-surgery-for-nonmelanoma-head-and-neck-skin-cancer
#11
Brandon T Beal, Emily K White, Anit K Behera, Amy E Zavell, Ashley E McGuinness, Holly Blangger, Eric S Armbrecht, Ian A Maher
BACKGROUND: Most skin cancers occur on the head and neck, areas of the body that are significant to an individual's body image (BI) perception. Poor BI is a robust risk factor for depression and decreased quality of life. Thus, patients with nonmelanoma head and neck skin cancer (NMHNSC) may be more vulnerable to BI disturbance and the negative sequelae of poor BI. OBJECTIVE: Describe the nature of BI concerns in patients diagnosed with NMHNSC and assess how BI changes with treatment...
May 24, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29799979/assessment-of-frontalis-myocutaneous-transposition-flap-for-forehead-reconstruction-after-mohs-surgery
#12
Alejandra Tomás-Velázquez, Pedro Redondo
Importance: Forehead reconstruction after Mohs surgery has become a challenge for dermatology surgeons, and achieving an excellent cosmetic and functional result is imperative in this location. Objective: To highlight the utility of a frontalis myocutaneous transposition flap (FMTF) for forehead reconstruction after Mohs surgery. Design, Setting, and Participants: Surgical technique case series including 12 patients with large forehead defects recruited between January 2010 and June 2017 at the Dermatology Department of the University Clinic of Navarra, Spain...
May 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29796321/mistaken-diabetic-ulcers-a-case-of-bilateral-foot-verrucous-carcinoma
#13
Vanessa Di Palma, Jill P Stone, Andrew Schell, Jeffrey C Dawes
Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. Treatment is complete surgical resection, ideally by Mohs micrographic surgery, to ensure adequate clear margins. Cutaneous VC predominantly occurs on the plantar surface of the foot and rarely occurs in multiple sites. This case study describes the fourth reported occurrence of bilateral VC of the feet in a woman with chronic diabetic foot ulcers...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29785327/ex-vivo-confocal-microscopy-an-emerging-technique-in-dermatology
#14
Elisa Cinotti, Jean Luc Perrot, Bruno Labeille, Frédéric Cambazard, Pietro Rubegni
This review aims to give an overview of the current available applications of ex vivo confocal microscopy (EVCM) in dermatology. EVCM is a relatively new imaging technique that allows microscopic examination of freshly excised unfixed tissue. It enables a rapid examination of the skin sample directly in the surgery room and thus represents an alternative to the intraoperative micrographic control of the surgical margins of cutaneous tumors by standard microscopic examination on cryopreserved sections during Mohs surgery...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29774540/conservative-thickness-layers-in-mohs-micrographic-surgery
#15
Stanislav N Tolkachjov, Jonathan A Cappel, Elizabeth A Bryant, Christopher B Harmon
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors' aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique may be most useful. METHODS: We performed a retrospective chart review of patients with tumors treated with CTL in MMS of 339 tumors, recording patient demographics, tumor characteristics, MMS stages for clearance, repairs, complications, and follow-up...
May 17, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29770284/solitary-palmar-keratoacanthoma-case-report
#16
Raghavendra L Girijala, Young Kwak, David Wright, Leonard H Goldberg
Keratoacanthoma (KA) is a squamous neoplasm exhibiting a triphasic growth pattern involving rapid growth, stabilization, and eventual spontaneous resolution. Historically, keratoacanthomas were thought to originate on hair-bearing skin or sun-exposed surfaces. However, recent reports demonstrate that they can occur on the mucous membranes, subungual regions, and palms and soles. We report a 74-year-old man who developed a KA on the left palmar surface after minor trauma, for which he underwent Mohs' micrographic surgery...
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29765274/review-of-eyelid-reconstruction-techniques-after-mohs-surgery
#17
REVIEW
Sagar Yatin Patel, Kamel Itani
Mohs micrographic surgery achieves high cure rates while preserving healthy tissue making it the optimal treatment for skin cancer. The goals of eyelid reconstruction after Mohs surgery include restoring eyelid structure and function while attaining acceptable aesthetic results. Given the variety of eyelid defects encountered after Mohs surgery, a thorough understanding of the complex eyelid anatomy as well as an in-depth knowledge of the numerous reconstructive techniques available are required to accomplish these reconstructive goals...
May 2018: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/29765269/mohs-micrographic-surgery-development-technique-and-applications-in-cutaneous-malignancies
#18
REVIEW
Eillen Luisa A Chen, Divya Srivastava, Rajiv I Nijhawan
Mohs micrographic surgery (MMS) is a specialized technique for treating skin malignancies that offers the highest cure rate by allowing histological evaluation of the entire peripheral and deep margins. MMS also maximally preserves as much uninvolved, normal adjacent tissue as possible, allowing for the best cosmetic and functional outcomes. When used for appropriate indications, this technique is also more cost-effective than other treatment modalities. In this article, the authors will discuss the development of MMS, the steps involved in this procedure, and the indications for this technique...
May 2018: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/29763492/perianal-extramammary-paget-disease-treated-with-topical-imiquimod-and-oral-cimetidine
#19
Jayla Gray, Arielle Gray, James Swan, Joshua Eberhardt, Kumaran Mudaliar, Rebecca Tung
Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma. The current mainstay of treatment is wide local excision. We present the case of a 56-year-old woman with perianal EMPD that recurred 4 years after initial treatment with wide local excision with Mohs micrographic surgery tissue processing of marginal tissue. Upon recurrence with anal canal involvement, the patient was treated with a 16-week combination course of topical imiquimod and oral cimetidine. There is growing evidence to support both the use of topical imiquimod for the treatment of EMPD as well as the antioncogenic effects of oral cimetidine...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29763491/penile-squamous-cell-carcinoma-with-urethral-extension-treated-with-mohs-micrographic-surgery
#20
Ardeshir E Nadimi, Ali Hendi
Penile squamous cell carcinoma (SCC) with considerable urethral extension is uncommon and difficult to manage. It often is resistant to less invasive and nonsurgical treatments and frequently results in partial or total penectomy, which can lead to cosmetic disfigurement, functional issues, and psychological distress. We report a case of penile SCC in situ with considerable urethral extension with a focus of cells suspicious for moderately well-differentiated and invasive SCC that was treated with Mohs micrographic surgery (MMS)...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
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