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https://www.readbyqxmd.com/read/28542464/maternal-low-thyroxin-levels-are-associated-with-adverse-pregnancy-outcomes-in-a-chinese-population
#1
Yong Zhang, Xiaobei Dai, Shuai Yang, Chen Zhang, Mi Han, He-Feng Huang, Jianxia Fan
Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have different effects on pregnancy outcomes. The study included 6,031 mothers who provided both first and third pregnancy serum samples for analyses of thyroid function...
2017: PloS One
https://www.readbyqxmd.com/read/28537582/thyroid-homeostasis-in-mother-child-pairs-in-relation-to-maternal-iodine-status-the-misa-study
#2
V Berg, T H Nøst, G Skeie, Y Thomassen, B Berlinger, A S Veyhe, R Jorde, J Ø Odland, S Hansen
BACKGROUND/OBJECTIVES: Iodine deficiency during pregnancy may influence maternal and foetal thyroid function with the risk of causing neurocognitive and psychomotor deficits in the offspring. The objective of this study was to assess iodine status in pregnant women from Northern Norway and to investigate the influence of iodine status on maternal and infant thyroid function. SUBJECTS/METHODS: Women from the Northern Norway Mother-and-Child contaminant Cohort Study (MISA) donated a blood and urine sample at three visits during their pregnancy and postpartum period (in second trimester, 3 days and 6 weeks after delivery...
May 24, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28521160/evidence-for-bisphenol-a-induced-disruption-of-maternal-thyroid-homeostasis-in-the-pregnant-ewe-at-low-level-representative-of-human-exposure
#3
Davy Guignard, Véronique Gayrard, Marlène Z Lacroix, Sylvie Puel, Nicole Picard-Hagen, Catherine Viguié
Many uncertainties remain regarding the potential of bisphenol A (BPA) as a thyroid disruptor in mammals and the relevance of experimental data to humans. The relevance of the exposure schemes used in experimental in vivo studies is also a major source of uncertainty when analysing the risk of BPA exposure for human health. In this context, the goals of our study, conducted in an ovine model relevant to human gestation and thyroid physiologies, were to: 1) determine the equivalence of subcutaneous and dietary exposures and 2) determine if environmentally relevant doses of BPA can alter gestational and newborn thyroid functions...
May 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28511580/deleterious-effects-from-occupational-exposure-to-ethylene-thiourea-in-pregnant-women
#4
Abby D Mutic, Brenda J Baker, Linda A McCauley
Human exposure to endocrine disrupting chemicals (EDCs) has become common as a result of widespread application of these chemicals to the food supply, environmental contamination, and occupational exposures (Caserta et al., 2011). However, relatively little is known about the effects of EDCs such as ethylene thiourea (ETU) in developing fetuses and the lasting implications of this disruption on human development from birth through adulthood. Of highest concern are chronic, low-dose exposures among industrial and agricultural workers...
May 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28500083/hepatic-thyroid-signaling-of-heat-stressed-late-pregnant-and-early-lactating-cows
#5
Joachim Weitzel, Thorsten Viergutz, Dirk Albrecht, Rupert M Bruckmaier, Marion Schmicke, Armin Tuchscherer, Franziska Koch, Björn Kuhla
During the transition between late gestation and early lactation dairy cows experience severe metabolic stress due to the high energy and nutrient requirements of the fetus and the mammary gland. Additional thermal stress as occurring with rising temperatures during the ongoing climate change has further adverse implications on energy intake, metabolism and welfare. The thyroid hormone (TH)-mediated cellular signaling has a pivotal role in regulation of body temperature, energy intake and metabolic adaptation to heat...
May 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28494269/medical-conditions-associated-with-recurrent-miscarriage-is-bmi-the-tip-of-the-iceberg
#6
Mushi J Matjila, Anne Hoffman, Zephne M van der Spuy
BACKGROUND: In contrast to sporadic miscarriage, recurrent miscarriage (RM) is a rare entity which affects 1% of couples attempting conception. It is distressing for couples and healthcare professionals as the aetiology is unclear with limited treatment options. Apart from anti-phospholipid syndrome (APS), the strength of associations between RM and commonly investigated endocrine, autoimmune, thrombophilic and uterine structural abnormalities remains uncertain and variable. OBJECTIVES: To assess the prevalence of commonly investigated medical conditions associated with RM...
May 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28485783/influence-of-screening-and-intervention-of-hyperthyroidism-on-pregnancy-outcome
#7
Y Wang, X-L Sun, C-L Wang, H-Y Zhang
OBJECTIVE: To discuss the influence of screening and intervention of hyperthyroidism on pregnancy outcome. PATIENTS AND METHODS: The clinical data of 122 pregnant women who had been confirmed with hyperthyroidism from April 2012 to July 2014 in the Weifang People's Hospital were analyzed retrospectively (25 untreated, 97 treated). 60 with normal pregnancy check were randomly selected as control group. The pregnancy outcomes of the two groups of patients were analyzed...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28480843/prognostic-risk-of-obstetric-and-perinatal-complications-in-pregnant-women-with-thyroid-dysfunction
#8
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
Maternal thyroid pathology takes important role in obstetric and peri-neonatal morbidity structure. Despite of the number of studies conducted in the field of thyroid disorders of pregnant females, the definition of influence of thyroid gland dysfunction on maternal and neonatal health still remains actual. The mentioned topics draw specific interest in the aspect of prognosticaiton of complications and unfavorable outcome. Aim of the study - to define the specificities of gestation period and determine the prognostic risk of obstetric and perinatal complications in pregnant females with thyroid pathology...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28472893/prevalence-and-related-factors-of-irregular-menstrual-cycles-in-korean-women-the-5th-korean-national-health-and-nutrition-examination-survey-knhanes-v-2010-2012
#9
Eun-Kyung Jung, Seok-Won Kim, Sun-Myeong Ock, Kyu-In Jung, Chan-Hee Song
INTRODUCTION: There have been few population-based studies reporting medical, lifestyle and psychological factors associated with irregular menstrual cycles. This study aimed to elucidate the prevalence and related factors of irregular menstrual cycles in Korean women. METHODS: Cross-sectional data from the 5th Korean National Health and Nutrition Examination Survey were used. Eligible women were 19-40 years old, not currently taking oral contraceptives or using intrauterine devices, and not currently pregnant or breast feeding, and had no medical history of hysterectomy, thyroid diseases, cancers or renal failure...
May 4, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28467346/chronic-anemia-and-thyroid-function
#10
Ashraf T Soliman, Vincenzo De Sanctis, Mohamed Yassin, Magda Wagdy, Nada Soliman
Anaemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. Iron deficiency anaemia (IDA) impairs thyroid metabolism in animals and human and may negatively affect growth and develpment of children. On the other hand both overt and subclinical hypothyroidism are associated with anemia and adding iron to thyroxine therapy improves both conditions compared to thyroxine therapy alone...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28454782/radiation-dose-and-risks-to-fetus-from-nuclear-medicine-procedures
#11
Michael G Stabin
This article discusses issues regarding administration of radiopharmaceuticals to pregnant women. Standardized dose estimates and possible biological effects on the unborn child are presented. Current and future mathematical models (phantoms) are discussed. Standardized dose estimates for pregnant women at several stages of gestation based on the current generation of phantoms are given. Issues related to administration of radioiodines, particularly (131)I-NaI, are presented. Iodine concentrates in the fetal thyroid and therefore can give very high doses, even resulting in complete destruction of the fetal thyroid...
April 25, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28448812/effect-of-exposure-to-p-p%C3%A2-dde-during-the-first-half-of-pregnancy-in-the-maternal-thyroid-profile-of-female-residents-in-a-mexican-floriculture-area
#12
José Ángel Hernández-Mariano, Luisa Torres-Sánchez, Susana Bassol-Mayagoitia, Maria Consuelo Escamilla-Nuñez, Mariano E Cebrian, Érika Adriana Villeda-Gutiérrez, Guadalupe López-Rodríguez, Eunice Elizabeth Félix-Arellano, Julia Blanco-Muñoz
BACKGROUND: Dichlorodiphenyldichloroethene (p,p´-DDE), the main metabolite of dichlorodiphenyltrichloroethane (DDT), has been associated with changes in human thyroid hormone levels. Maternal thyroid hormones are essential for adequate fetal neurodevelopment during the first half of pregnancy. OBJECTIVE: To evaluate the association between maternal p,p´-DDE concentration and the maternal thyroid profile during the first half of pregnancy. MATERIALS AND METHODS: We analyzed the information of 430 pregnant women from a Mexican floriculture area, with a gestational age ≤16 weeks...
April 24, 2017: Environmental Research
https://www.readbyqxmd.com/read/28447527/serum-thyroid-hormone-levels-among-chinese-pregnant-women
#13
Yunxian Yu, Xiawei Li, Shuying Jiang, Wen Jiang, Jinhua Wu, Zhaopin Wang, Shuojia Wang, Minchao Li, Haigeng Xu, Yun Lv, Jinxing Jiang, Yongfeng Ding, Boer Zhang
AIM: The aim of this study is to examine gestational serum thyroid hormone levels and influencing factors among Chinese pregnant women with high dietary iodine intake. METHODS: The study was conducted from 2011 and 2013 in Zhoushan Women & Children's Hospital, Zhejiang, China. A total of 1991 pregnant women were enrolled and their serum levels of free thyroid hormones (FT4, FT3, and TSH) were detected by chemiluminescence method. RESULTS: Gestational serum FT4 and FT3 decreased with gestational week while TSH increased...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28446078/serial-neck-ultrasonographic-evaluation-of-changes-in-papillary-thyroid-carcinoma-during-pregnancy
#14
Hye-Seon Oh, Won Gu Kim, Suyeon Park, Mijin Kim, Hyemi Kwon, Min Ji Jeon, Jeong Hyun Lee, Jung Hwan Baek, Dong Eun Song, Tae Yong Kim, Young Kee Shong, Won Bae Kim
BACKGROUND: Papillary thyroid cancer (PTC) is a common malignancy diagnosed during pregnancy. However, there is little information on the behavior of PTC during pregnancy. The aim of this study was to evaluate the natural course of PTC in pregnant women. METHODS: The study included 19 patients with PTC who delayed thyroid surgery because they were diagnosed with PTC just before or during the early stages of pregnancy. Serial neck ultrasonography (US) was used to evaluate PTCs before surgical treatment and the clinical outcomes after surgery...
May 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28443254/perfluoroalkyl-substances-exposure-and-thyroid-hormones-in-humans-epidemiological-observations-and-implications
#15
REVIEW
Jung Eun Lee, Kyungho Choi
Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Due to their unique physicochemical characteristics, PFASs have been used as surfactants and surface coating materials in many applications...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28427038/urinary-triclosan-concentrations-during-pregnancy-and-birth-outcomes
#16
Taylor M Etzel, Antonia M Calafat, Xiaoyun Ye, Aimin Chen, Bruce P Lanphear, David A Savitz, Kimberly Yolton, Joseph M Braun
BACKGROUND: Triclosan is an antimicrobial chemical used in consumer products, and exposure is ubiquitous among pregnant women in the United States. Triclosan may reduce the levels of thyroid hormones that are important for fetal growth and development. OBJECTIVE: We investigated the relationship of prenatal triclosan exposure with birth anthropometry and gestational duration. METHODS: We used data from 378 mother-child pairs participating in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort from Cincinnati, OH...
April 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28414788/patients-with-subclinical-hypothyroidism-before-20-weeks-of-pregnancy-have-a-higher-risk-of-miscarriage-a-systematic-review-and-meta-analysis
#17
REVIEW
Yibing Zhang, Haoyu Wang, Xifeng Pan, Weiping Teng, Zhongyan Shan
OBJECTIVE: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy. METHODS: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage...
2017: PloS One
https://www.readbyqxmd.com/read/28412871/the-effect-of-oil-and-water-soluble-contrast-medium-in-hysterosalpingography-on-thyroid-function
#18
Shuhei So, Wakasa Yamaguchi, Hiroko Tajima, Takeshi Nakayama, Naoaki Tamura, Naohiro Kanayama, Fumiko Tawara
Hysterosalpingography (HSG) using iodinated contrast medium is X-ray diagnostic test that examines the inside of the uterus and fallopian tubes in infertile women. In this study, we compared thyroid function (thyroid stimulating hormone: TSH and free-T4: FT4 levels) after HSG with an oil-soluble contrast medium (OSCM) and a water-soluble contrast medium (WSCM). One hundred and sixty-four and 94 patients with normal thyroid function received HSG with OSCM and WSCM, respectively. Approximately 25% of the women in the OSCM group developed subclinical hypothyroidism (SCH), whereas only less than 10% of the patients in the WSCM group developed SCH...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28410473/thyroid-hormone-parameters-during-pregnancy-in-relation-to-urinary-bisphenol-a-concentrations-a-repeated-measures-study
#19
Max T Aung, Lauren E Johns, Kelly K Ferguson, Bhramar Mukherjee, Thomas F McElrath, John D Meeker
BACKGROUND: Maternal supply of thyroid hormones during pregnancy serves a critical role in fetal development. Although animal and in vitro studies provide evidence for thyroid hormone disruption as a result of bisphenol A (BPA) exposure, there is still a lack of evidence in human studies, particularly in the context of pregnancy. OBJECTIVES: We aimed to explore the associations between urinary BPA concentrations and plasma thyroid hormone parameters during gestation in pregnant women, and also investigated potential windows of vulnerability during gestation...
April 11, 2017: Environment International
https://www.readbyqxmd.com/read/28395858/association-between-exposure-to-organochlorine-compounds-and-maternal-thyroid-status-role-of-the-iodothyronine-deiodinase-1-gene
#20
Sabrina Llop, Mario Murcia, Mar Alvarez-Pedrerol, Joan O Grimalt, Loreto Santa-Marina, Jordi Julvez, Fernando Goñi-Irigoyen, Mercedes Espada, Ferran Ballester, Marisa Rebagliato, Maria-Jose Lopez-Espinosa
INTRODUCTION: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action. AIM: To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes. METHODS: The study population (n=1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003-2006)...
April 8, 2017: Environment International
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