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https://www.readbyqxmd.com/read/28327186/clinical-behavioural-and-pharmacogenomic-factors-influencing-the-response-to-levothyroxine-therapy-in-patients-with-primary-hypothyroidism-protocol-for-a-systematic-review
#1
Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce, Scott Wilkes
BACKGROUND: Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28323629/effects-of-levothyroxine-on-pregnancy-outcomes-in-women-with-thyroid-dysfunction-a-meta-analysis-of-randomized-controlled-trials
#2
Jia Li, Jie Shen, Lan Qin
Context • Subclinical hypothyroidism (SCH) in pregnancy can be associated with increased complications in pregnant women and neurocognitive deficits in fetuses. Two recently published meta-analyses investigated the effects of levothyroxine (LT4) supplementation on pregnancy outcomes but did not report adverse complications and neonatal outcomes. Objectives • The study intended to assess the effects of LT4 supplementation in the treatment of pregnant women with thyroid dysfunction. Design • The research team performed a meta-analysis of randomized controlled trials (RCTs) published in PubMed, Embase, Web of Science, Chinese BioMedical Literature Service System, and China National Knowledge Infrastructure databases...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28322679/iodine-deficiency-clinical-implications
#3
REVIEW
Soamsiri Niwattisaiwong, Kenneth D Burman, Melissa Li-Ng
Iodine is crucial for thyroid hormone synthesis and fetal neurodevelopment. Major dietary sources of iodine in the United States are dairy products and iodized salt. Potential consequences of iodine deficiency are goiter, hypothyroidism, cretinism, and impaired cognitive development. Although iodine status in the United States is considered sufficient at the population level, intake varies widely across the population, and the percentage of women of childbearing age with iodine deficiency is increasing. Physicians should be aware of the risks of iodine deficiency and the indications for iodine supplementation, especially in women who are pregnant or lactating...
March 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28294052/iodine-deficiency-and-iodine-prophylaxis-in-pregnancy
#4
Małgorzata Trofimiuk-Müdlner, Alicja Hubalewska-Dydejczyk
BACKGROUND: Physiological changes in pregnancy result in increased iodine demand, which may not be met in areas of mild-to-moderate iodine deficiency or borderline sufficiency. As a pregnant woman is the only source of thyroid hormones for her child during early gestation, iodine deficiency-induced hypothyroxinemia may have deleterious effects on fetal development. OBJECTIVE: To present the current approach to iodine deficiency and its prophylaxis during pregnancy...
March 9, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28286688/beneficial-effects-on-pregnancy-outcomes-of-thyroid-hormone-replacement-for-subclinical-hypothyroidism
#5
Norman J Blumenthal, Creswell J Eastman
Background. Hypothyroidism and raised thyroid antibody levels have been associated with adverse obstetrical outcomes. Several studies have investigated causal associations, but results have been inconsistent and few studies have reported the effects of thyroxine replacement therapy on pregnancy outcomes in hypothyroid patients. Objective. The primary study objective was to determine the outcome of pregnancies in women diagnosed with overt and subclinical hypothyroidism (SCH) (serum TSH > 2.5 mIU/L) and those with elevated circulating thyroid autoantibody levels in the first trimester of pregnancy and after the institution of appropriate thyroxine replacement therapy to maintain the serum TSH ≤ 2...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28279065/proteomic-biomarkers-for-bisphenol-a-early-exposure-and-women-s-thyroid-cancer
#6
Ho-Sun Lee, Yunkyeong Kang, Kyung Tae, Gyu-Un Bae, Jong Y Park, Yoon Hee Cho, Mihi Yang
Purpose: For the target treatment and prevention of women's increased thyroid cancer, we focused on risks of environmental exposure to endocrine disrupting chemicals, particularly bisphenol A (BPA), and its high susceptible exposure- timing, particularly early exposure in lives. Materials and Methods: Female ICR mice were exposed to BPA in utero and in early life (15, 75 and 300 mg/L of drinking water via pregnant mice and lactation). We identified BPA-responsive proteins in mice thyroid by 2D-PAGE, image analyses, and ESI-Q-TOF MS...
March 8, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28263825/evaluation-of-the-risk-of-perchlorate-exposure-in-a-population-of-late-gestation-pregnant-women-in-the-united-states-application-of-probabilistic-biologically-based-dose-response-modeling
#7
A Lumen, N I George
The risk of ubiquitous perchlorate exposure and the dose-response on thyroid hormone levels in pregnant women in the United States (U.S.) have yet to be characterized. In the current work, we integrated a previously developed perchlorate submodel into a recently developed population-based pregnancy model to predict reductions in maternal serum free thyroxine (fT4) levels for late-gestation pregnant women in the U.S. Our findings indicated no significant difference in geometric mean estimates of fT4 when perchlorate exposure from food only was compared to no perchlorate exposure...
March 2, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28260449/living-kidney-donor-cancellation-at-king-hussein-medical-center
#8
Katibh Al-Rabadi, Reham Issa Almardini, Mysoon Hajeer, Mahmood Hendawi, Aiham Hadad
OBJECTIVES: Living-related kidney donation is the main source of renal grafts in Jordan, since kidneys from deceased donors are scarce. Although the Jordanian community accepts the idea of kidney donation to family members, not all potential donors manage to complete the required psychologic and medical evaluations. We review the causes of kidney-donation cancellation and suggest options to increase the number of available organs. MATERIALS AND METHODS: We performed a retrospective chart review of all potential living-related kidney donors at King Hussein Medical Center between January 2008 and June 2016...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260263/iodine-supplementation-for-women-during-the-preconception-pregnancy-and-postpartum-period
#9
REVIEW
Kimberly B Harding, Juan Pablo Peña-Rosas, Angela C Webster, Constance My Yap, Brian A Payne, Erika Ota, Luz Maria De-Regil
BACKGROUND: Iodine is an essential nutrient required for the biosynthesis of thyroid hormones, which are responsible for regulating growth, development and metabolism. Iodine requirements increase substantially during pregnancy and breastfeeding. If requirements are not met during these periods, the production of thyroid hormones may decrease and be inadequate for maternal, fetal and infant needs. The provision of iodine supplements may help meet the increased iodine needs during pregnancy and the postpartum period and prevent or correct iodine deficiency and its consequences...
March 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28251103/correlation-of-enhanced-oxidative-stress-with-altered-thyroid-profile-probable-role-in-spontaneous-abortion
#10
Kaur Ramandeep, Gupta Kapil, Kaur Harkiran
BACKGROUND: Spontaneous abortion or miscarriage is defined as the loss of a clinically recognized pregnancy that occurs before 20 weeks of gestational age. Changes in thyroid function can impact greatly on reproductive function before, during, and after conception. Oxidative stress affects both implantation and early embryo development by modifying the key of transcription. Malondialdehyde (MDA) is a major breakdown product of split off from lipid peroxidation. Superoxide dismutase (SOD) is responsible for detoxification of superoxide anion and required for normal health and reproduction...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28229359/thyroid-volume-and-serum-calcitonin-changes-during-pregnancy
#11
G Vannucchi, D Covelli, B Vigo, M Perrino, L Mondina, L Fugazzola
BACKGROUND: Pregnancy has a profound impact on thyroid homeostasis which results in change of thyroid function and thyroid volume (TV). Moreover, calcitonin (CT), and its gene-related peptide have been demonstrated to play an important role in the implantation process. PURPOSE: To evaluate changes in TV and serum CT levels during pregnancy. METHODS: One hundred and fifty-five pregnant women were consecutively enrolled at the first trimester of gestation and underwent clinical, biochemical and sonographic assessment at enrollment, at the second and third trimesters and at 6 months after delivery...
February 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28215206/iodine-intakes-and-status-in-irish-adults-is-there-cause-for-concern
#12
Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Christina Tlustos, Michael J Gibney
I is an important mineral for health, required for the production of key thyroid hormones, which are essential for cellular metabolism, growth and physical development. Hence, adequate I is crucial at all stages of life, but imperative during pregnancy for fetal brain development and during a child's early life for neurodevelopment. Within Ireland, limited information exists on population I intakes and status. Therefore, the purposes of the present analysis were to estimate dietary I intakes and to analyse urinary iodine (UI) status using the cross-sectional National Adult Nutrition Survey 2008-2010 and the most recent Irish Total Diet Study...
February 20, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28212640/urinary-iodine-in-early-pregnancy-is-associated-with-subclinical-hypothyroidism-in-tianjin-china-an-observational-study
#13
Kunling Wang, Jie Zhang, Fengao Li, Wanqi Zhang, Hao Wang, Li Ding, Yaxin Liu, Laixiang Lin, Shuang Zhang, Mei Zhu
BACKGROUND: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. METHODS: A total of 115 women with SH and 104 women with euthyroidism (EH) in early pregnancy in Tianjin, China were investigated, and their serum thyroid-stimulating hormone, free thyroxine, free triiodothyronine, anti-thyroid peroxidase antibody (TPOAb), anti-thyroid globulin antibody (TGAb), urinary iodine (UIC), and urinary creatinine (UCr) concentrations were measured...
February 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28203373/a-silent-skull-metastatic-follicular-thyroid-carcinoma-mimicking-as-a-benign-scalp-tumor-in-a-pregnant-woman
#14
Tsung-Chun Huang, Yu-Kai Cheng, Tsung-Wei Chen, Yung-Chang Hsu, En-Wei Liu, Hsin-Han Chen
Thyroid cancer with cranial metastasis in a pregnant woman is very rare. In the literature, most cases are diagnosed early from neurogenic signs or symptomatic thyroid gland. Pregnancy also contributes to a hesitation toward early surgical and medical treatments. We reported a scalp tumor in a physically healthy 37-year-old pregnant female with a follicular thyroid carcinoma (FTC) with lung, bone and cranial metastasis in initial presentation. Silent neurogenic and physical examinations make an early diagnosis very challenging...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28202636/moderate-to-severe-iodine-deficiency-in-the-first-1000-days-causes-more-thyroid-hypofunction-in-infants-than-in-pregnant-or-lactating-women
#15
Sara Stinca, Maria Andersson, Isabelle Herter-Aeberli, Laila Chabaa, Mohamed Cherkaoui, Nawal El Ansari, Abdelmounaim Aboussad, Sandra Weibel, Michael B Zimmermann
Background: Iodine deficiency early in the life cycle-the "first 1000 days"-can cause hypothyroidism and irreversibly impair neuromotor development. However, the relative vulnerability among women and infants during this critical period is unclear, making it difficult for country-based programs with limited resources to prioritize their iodine interventions.Objective: Our aim was to determine the prevalence of thyroid hypofunction in women and infants living in an area of moderate-to-severe iodine deficiency...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28194837/comparison-of-thyroid-function-tests-and-blood-count-in-pregnant-women-with-versus-without-gestational-diabetes-mellitus
#16
Suheyla Gorar, Gul Babacan Abanonu, Aysel Uysal, Onur Erol, Aysun Unal, Seyit Uyar, Ayhan Hilmi Cekin
AIM: The aim of this study was to compare thyroid function and complete blood count parameters in pregnant women with versus without gestational diabetes mellitus (GDM). METHODS: A total of 269 pregnant women patients with (n = 110, GDM group) or without (n = 159, non-GDM group) GDM were included in this study. Data on age, rate of cesarean section, birthweight of neonate, hemogram, and thyroid function tests were collected. Multivariate analysis was performed to determine factors predicting increased risk of GDM...
February 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28176564/thyroid-hormone-treatment-can-reduce-risk-of-pregnancy-loss
#17
(no author information available yet)
Pregnant women with mild thyroid problems who receive thyroid hormone treatment have a decreased risk of pregnancy loss, suggest US researchers.
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28171716/reference-intervals-of-thyroid-hormones-during-pregnancy-in-korea-an-iodine-replete-area
#18
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-Young Oh
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. Methods: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies...
February 8, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28139946/multiple-sclerosis-in-pregnancy-prevalence-sociodemographic-features-and-obstetrical-outcomes
#19
Alex Fong, Cindy T Chau, Cara Quant, Jennifer Duffy, Deyu Pan, Dotun A Ogunyemi
OBJECTIVE: We sought to describe the prevalence, sociodemographic features, and antenatal/peripartum outcomes of multiple sclerosis (MS) in pregnancy. STUDY DESIGN: A retrospective cohort study was performed using deliveries in California from 2001-2009. Cases of MS as well as other morbidities were identified via ICD-9-CM code. Logistic regression was performed to adjust for potential confounders. RESULTS: 1,185 out of 4,424,049 deliveries were complicated by MS...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28130433/the-association-of-maternal-thyroid-function-with-placental-hemodynamics
#20
M Barjaktarovic, T I M Korevaar, L Chaker, V W V Jaddoe, Y B de Rijke, T J Visser, E A P Steegers, R P Peeters
STUDY QUESTION: What is the clinical association of maternal thyroid function with placental hemodynamic function? SUMMARY ANSWER: A higher free thyroxine (FT4) concentration in early pregnancy is associated with higher placental vascular resistance. WHAT IS KNOWN ALREADY: Suboptimal placental function is associated with preeclampsia (which, in turn, further deteriorates placental hemodynamics and impairs the fetal blood supply), fetal growth restriction and premature delivery...
January 26, 2017: Human Reproduction
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