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https://www.readbyqxmd.com/read/28319050/extracellular-matrix-proteomics-identifies-molecular-signature-of-symptomatic-carotid-plaques
#1
Sarah R Langley, Karin Willeit, Athanasios Didangelos, Ljubica Perisic Matic, Philipp Skroblin, Javier Barallobre-Barreiro, Mariette Lengquist, Gregor Rungger, Alexander Kapustin, Ludmilla Kedenko, Chris Molenaar, Ruifang Lu, Temo Barwari, Gonca Suna, Xiaoke Yin, Bernhard Iglseder, Bernhard Paulweber, Peter Willeit, Joseph Shalhoub, Gerard Pasterkamp, Alun H Davies, Claudia Monaco, Ulf Hedin, Catherine M Shanahan, Johann Willeit, Stefan Kiechl, Manuel Mayr
BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asymptomatic patients to identify a protein signature for high-risk atherosclerotic plaques...
March 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28318446/science-to-practice-does-fdg-differentiate-morphologically-unstable-from-stable-atherosclerotic-plaque
#2
Vasken Dilsizian, Hossein Jadvar
It has been reported that fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) may detect the inflammatory state and macrophage burden of atherosclerotic plaques and potentially identify vulnerable plaques. However, published reports have been inconsistent in this area. Tavakoli et al ( 1 ) hypothesized that differential regulation of macrophage glucose metabolism by macrophage colony-stimulating factor (M-CSF; inflammation resolving) and granulocyte-M-CSF (GM-CSF; proinflammatory) may contribute to the inconsistency of FDG vessel wall inflammation...
April 2017: Radiology
https://www.readbyqxmd.com/read/28314799/coronary-atherosclerotic-vulnerable-plaque-current-perspectives
#3
REVIEW
Christodoulos Stefanadis, Christos-Konstantinos Antoniou, Dimitrios Tsiachris, Panagiota Pietri
No abstract text is available yet for this article.
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314627/n-%C3%AE%C2%B5-carboxymethyl-lysine-concentration-in-debris-from-carotid-artery-stenting-correlates-independently-with-signal-intensity-on-t1-weighted-black-blood-magnetic-resonance-images
#4
Ayumu Eto, Noriyuki Sakata, Ryoji Nagai, Jun-Ichi Shirakawa, Ritsurou Inoue, Fumiaki Kiyomi, Kouhei Nii, Hiroshi Aikawa, Minoru Iko, Masanori Tsutsumi, Kimiya Sakamoto, Fumihiro Hiraoka, Takahumi Mitsutake, Hayatsura Hanada, Kiyoshi Kazekawa
BACKGROUND AND PURPOSE: Because magnetic resonance imaging (MRI) focuses on the morphological characteristics of carotid artery plaques, its diagnostic value with respect to plaque vulnerability is limited. We examined the correlation between N(ε)-(carboxymethyl)lysine (CML), a main chemical structure of advanced glycation end-products, and the vulnerability of plaques visualized on MRI scans. MATERIALS AND METHODS: We enrolled 43 patients who had undergone carotid artery stenting (CAS) for carotid artery stenosis; all underwent MRI studies, including black-blood MRI and diffusion-weighted imaging (DWI)...
March 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28304220/high-resolution-magnetic-resonance-imaging-of-carotid-atherosclerotic-plaques-a-correlation-study-with-histopathology
#5
Zhangyong Xia, Hua Yang, Xiaochun Yuan, Jiyue Wang, Shigang Zhang, Liyong Zhang, Yang Qu, Jun Chen, Liqun Jiao, Le-Xin Wang, Yifeng Du
BACKGROUND: This study aimed to utilize high-resolution magnetic resonance imaging (MRI) to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. PATIENTS AND METHODS: High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fibrous cap rupture...
March 17, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28303857/research-progress-on-the-risk-factors-and-outcomes-of-human-carotid-atherosclerotic-plaques
#6
REVIEW
Xiang-Dong Xiong, Wei-Dong Xiong, Shang-Shen Xiong, Gui-Hai Chen
OBJECTIVE: Atherosclerosis is an inflammatory process that results in complex lesions or plaques that protrude into the arterial lumen. Carotid atherosclerotic plaque rupture, with distal atheromatous debris embolization, causes cerebrovascular events. This review aimed to explore research progress on the risk factors and outcomes of human carotid atherosclerotic plaques, and the molecular and cellular mechanisms of human carotid atherosclerotic plaque vulnerability for therapeutic intervention...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28298426/modeling-alzheimer-s-disease-in-mice-with-human-neurons
#7
Gaia Novarino
Human neurons transplanted into a mouse model for Alzheimer's disease show human-specific vulnerability to β-amyloid plaques and may help to identify new therapeutic targets.
March 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28288971/activation-of-cd137-signaling-promotes-angiogenesis-in-atherosclerosis-via-modulating-endothelial-smad1-5-nfatc1-pathway
#8
Jiayi Weng, Cuiping Wang, Wei Zhong, Bo Li, Zhongqun Wang, Chen Shao, Yao Chen, Jinchuan Yan
BACKGROUND: Excessive angiogenesis is a key feature of vulnerable atherosclerotic plaques, and is considered an independent predictor of cardiovascular risk. CD137 signaling has previously been shown to be involved in atherosclerosis. However, the possible role of CD137 signaling in regulating angiogenesis has not been reported. METHODS AND RESULTS: Apolipoprotein E-deficient (ApoE(-/-)) mice were used as the in vivo model of atherosclerosis. Masson and immunohistochemical analysis of atherosclerotic plaques and Matrigel plug assay were used to evaluate the angiogenesis...
March 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28283423/echolucency-of-the-carotid-artery-is-associated-with-short-term-plaque-progression-and-positive-remodeling-in-the-culprit-coronary-artery-in-ami-survivors
#9
Mika Futamata, Satoshi Matsuoka, Takuya Shimizu, Toru Yoshizaki, Jun-Ei Obata, Takamitsu Nakamura, Daisuke Fujioka, Yosuke Watanabe, Kazuto Nakamura, Kazuhiro Watanabe, Kiyotaka Kugiyama
BACKGROUND: Rapid plaque progression and positive remodeling are recognized as vulnerable coronary plaque characteristics. This study examined whether serial carotid ultrasonography might be of value for assessment of coronary plaque progression and positive remodeling, measured by serial intravascular ultrasound (IVUS), in survivors of acute myocardial infarction (AMI). METHODS: Thirty-nine patients with AMI had repeated examinations by IVUS of culprit coronary arteries and echolucency of the coronary artery on admission (1st test) and 6 months later (2nd test)...
March 7, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28279371/carotid-plaque-lipid-content-and-fibrous-cap-status-predict-systemic-cv-outcomes-the-mri-substudy-in-aim-high
#10
Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Moni B Neradilek, Daniel A Isquith, Kiyofumi Yamada, Gádor Cantón, John R Crouse, Todd J Anderson, John Huston, Kevin O'Brien, Daniel S Hippe, Nayak L Polissar, Chun Yuan, Thomas S Hatsukami
OBJECTIVES: The aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease. BACKGROUND: Advancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden. METHODS: As part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28274754/noninvasive-characterization-of-carotid-plaque-strain
#11
Amir A Khan, Siddhartha Sikdar, Thomas Hatsukami, Juan Cebral, Michael Jones, John Huston, George Howard, Brajesh K Lal
OBJECTIVE: Current risk stratification of internal carotid artery plaques based on diameter-reducing percentage stenosis may be unreliable because ischemic stroke results from plaque disruption with atheroembolization. Biomechanical forces acting on the plaque may render it vulnerable to rupture. The feasibility of ultrasound-based quantification of plaque displacement and strain induced by hemodynamic forces and their relationship to high-risk plaques have not been determined. We studied the feasibility and reliability of carotid plaque strain measurement from clinical B-mode ultrasound images and the relationship of strain to high-risk plaque morphology...
March 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28271001/fully-integrated-optical-coherence-tomography-ultrasound-and-indocyanine-green-based-fluorescence-tri-modality-system-for-intravascular-imaging
#12
Yan Li, Joseph Jing, Yueqiao Qu, Yusi Miao, Buyun Zhang, Teng Ma, Mingyue Yu, Qifa Zhou, Zhongping Chen
We present a tri-modality imaging system and fully integrated tri-modality probe for intravascular imaging. The tri-modality imaging system is able to simultaneously acquire optical coherence tomography (OCT), ultrasound (US), and fluorescence imaging. Moreover, for fluorescence imaging, we used the FDA-approved indocyanine green (ICG) dye as the contrast agent to target lipid-loaded macrophages. We conducted imaging from a male New Zealand white rabbit to evaluate the performance of the tri-modality system...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28268915/clinical-viability-of-carotid-plaque-strain-estimation-using-b-mode-ultrasound-image-sequences
#13
Amir A Khan, Joseph C Hecker, Brajesh K Lal, Siddhartha Sikdar
It is estimated that approximately 30% of ischemic strokes are caused by rupture of plaque in the carotid artery. Development of techniques focusing on identifying plaques that are vulnerable to rupture is thus indispensable for stroke prevention. Recent studies have demonstrated that motion analysis of plaques from B-mode and RF ultrasound (US) image sequences can be used to estimate plaque strain. However, viability of these methods in a clinical setting, with variable acquisition protocols, has not been demonstrated yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263852/potential-benefits-of-eicosapentaenoic-acid-on-atherosclerotic-plaques
#14
REVIEW
J R Nelson, O Wani, H T May, M Budoff
Residual cardiovascular (CV) risk remains in some patients despite optimized statin therapy and may necessitate add-on therapy to reduce this risk. Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, lowers plasma triglyceride levels without raising low-density lipoprotein cholesterol levels and has potential beneficial effects on atherosclerotic plaques. Animal studies have shown that EPA reduces levels of pro-inflammatory cytokines and chemokines. In clinical trials utilizing a wide spectrum of plaque imaging modalities, EPA has shown beneficial effects on plaque characteristics...
March 2, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28261097/curcumin-alleviates-oxldl-induced-mmp-9-and-emmprin-expression-through-the-inhibition-of-nf-%C3%AE%C2%BAb-and-mapk-pathways-in-macrophages
#15
Jiatian Cao, Bozhi Ye, Lu Lin, Lei Tian, Hongbo Yang, Changqian Wang, Weijian Huang, Zhouqing Huang
Rupture of vulnerable atherosclerotic plaques is the leading cause of acute myocardial infarction (AMI) and unstable angina pectoris (UA). However, it still lacks an effective therapy to stabilize the vulnerable atherosclerotic plaques. Numerous reports have shown that upregulation of MMP-9 (matrix metalloproteinase-9) and EMMPRIN (extracellular matrix metalloproteinase inducer) in macrophages is involved in the progression and development of vulnerable plaques. Here we evaluated the impact of curcumin on the expression of MMP-9 and EMMPRIN in macrophages...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28259375/sr-bi-a-multifunctional-receptor-in-cholesterol-homeostasis-and-atherosclerosis
#16
REVIEW
MacRae F Linton, Huan Tao, Edward F Linton, Patricia G Yancey
The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL's atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation...
March 1, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28259058/community-analysis-of-dental-plaque-and-endotracheal-tube-biofilms-from-mechanically-ventilated-patients
#17
Poala J Marino, Matt P Wise, Ann Smith, Julian R Marchesi, Marcello P Riggio, Michael A O Lewis, David W Williams
PURPOSE: Mechanically ventilated patients are at risk for developing ventilator-associated pneumonia, and it has been reported that dental plaque provides a reservoir of respiratory pathogens that may aspirate to the lungs and endotracheal tube (ETT) biofilms. For the first time, metataxonomics was used to simultaneously characterize the microbiome of dental plaque, ETTs, and non-directed bronchial lavages (NBLs) in mechanically ventilated patients to determine similarities in respective microbial communities and therefore likely associations...
February 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28258089/oncostatin-m-receptor-%C3%AE-deficiency-attenuates-atherogenesis-by-inhibiting-jak2-stat3-signaling-in-macrophages
#18
Xin Zhang, Jing Li, Juan-Juan Qin, Wen-Lin Cheng, Xueyong Zhu, Fu-Han Gong, Zhigang She, Zan Huang, Hao Xia, Hongliang Li
Oncostatin M (OSM) is a secreted cytokine mainly involved in chronic inflammatory and cardiovascular diseases through binding to OSM receptor β(OSMR-β). Recent studies demonstrated that the presence of OSM contributed to the destabilization of atherosclerotic plaque. To investigate whether OSMR-β deficiency affects atherosclerosis, male OSMR-β-/-ApoE-/- mice were generated and utilized. Here we observed OSMR-β expression was remarkably up-regulated in both human and mouse atherosclerotic lesions, which was mainly located in macrophages...
March 3, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28256179/invasive-or-non-invasive-imaging-for-detecting-high-risk-coronary-lesions
#19
REVIEW
Kush Patel, Jason Tarkin, Patrick W Serruys, Erhan Tenekecioglu, Nicolas Foin, Yao-Jun Zhang, Tom Crake, James Moon, Anthony Mathur, Christos V Bourantas
Advances in our understanding about atherosclerotic evolution have enabled us to identify specific plaque characteristics that are associated with coronary plaque vulnerability and cardiovascular events. With constant improvements in signal and image processing an arsenal of invasive and non-invasive imaging modalities have been developed that are capable of identifying these features allowing in vivo assessment of plaque vulnerability. Areas covered: This review article presents the available and emerging imaging modalities introduced to assess plaque morphology and biology, describes the evidence from the first large scale studies that evaluated the efficacy of invasive and non-invasive imaging in detecting lesions that are likely to progress and cause cardiovascular events and discusses the potential implications of the in vivo assessment of coronary artery pathology in the clinical setting...
March 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28250101/strength-of-silk-attachment-to-ilex-chinensis-leaves-in-the-tea-bagworm-eumeta-minuscula-lepidoptera-psychidae
#20
Jonas O Wolff, Julia Lovtsova, Elena Gorb, Zhendong Dai, Aihong Ji, Zhihui Zhao, Nan Jiang, Stanislav N Gorb
Silks play an important role in the life of various arthropods. A highly neglected prerequisite to make versatile use of silks is sufficient attachment to substrates. Although there have been some studies on the structure and mechanics of silk anchorages of spiders, for insects only anecdotal reports on attachment-associated spinning behaviour exist. Here, we experimentally studied the silk attachment of the pupae and last instar caterpillars of the tea bagworm Eumeta minuscula (Butler 1881) (Lepidoptera, Psychidae) to the leaves of its host plant Ilex chinensis We found that the bagworms spin attachment discs, which share some structural features with those of spiders, like a plaque consisting of numerous overlaid, looped glue-coated silk fibres and the medially attaching suspension thread...
March 2017: Journal of the Royal Society, Interface
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