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Vulnerable plaque

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https://www.readbyqxmd.com/read/28421362/selective-imaging-of-vascular-endothelial-growth-factor-receptor-1-and-receptor-2-in-atherosclerotic-lesions-in-diabetic-and-non-diabetic-apoe-mice
#1
Yared Tekabe, Lynne L Johnson, Krissy Rodriquez, Qing Li, Marina Backer, Joseph M Backer
PURPOSE: Plaque vulnerability is associated with inflammation and angiogenesis, processes that rely on vascular endothelial growth factor (VEGF) signaling via two receptors, VEGFR-1 and VEGFR-2. We have recently reported that enhanced uptake of scVEGF-PEG-DOTA/Tc-99m (scV/Tc) single photon emission computed tomography (SPECT) tracer that targets both VEGFR-1 and VEGFR-2, identifies accelerated atherosclerosis in diabetic relative to non-diabetic ApoE(-/-) mice. Since VEGFR-1 and VEGFR-2 may play different roles in atherosclerotic plaques, we reasoned that selective imaging of each receptor can provide more detailed information on plaque biology...
April 18, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28420872/hairy-enhancer-of-split-homologue-1-suppresses-vascular-endothelial-growth-factor-induced-angiogenesis-via-downregulation-of-osteopontin-expression
#2
Xing-Xing Yao, Jing-Bo Lu, Zhi-Dong Ye, Lei Zheng, Qian Wang, Zhi-Qi Lin, Hao Liu, Heng Wan, Fang-Yong Fu, Xian-Ying Huang, Jian-Chen Xiu, Zheng-Jun Liu, Yan-Wei Hu
Angiogenesis plays a critical role in the progression and vulnerability of atherosclerotic plaques; however, the orchestration of angiogenesis in atherosclerotic plaque formation remains unclear. The results of microarray analysis, real-time PCR and immunohistochemical analyses showed that Hairy/enhancer of split homologue-1 (Hes-1) expression was significantly decreased, while that of osteopontin (OPN) was increased, in atherosclerotic plaques. Meanwhile, immunofluorescence results demonstrated that both Hes-1 and OPN were expressed in endothelial cells (ECs) of neovessels in atherosclerotic plaques...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420816/coronary-atherosclerotic-plaque-characteristics-and-cardiovascular-risk-factors%C3%A3-insights-from-an-optical-coherence-tomography-study
#3
Roberta De Rosa, Mariuca Vasa-Nicotera, David M Leistner, Sophia M Reis, Claudia E Thome, Jes-Niels Boeckel, Stephan Fichtlscherer, Andreas M Zeiher
BACKGROUND: The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography...
April 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28413493/tgf-%C3%AE-1-and-timp1-double-directional-raav-targeted-by-utmd-in-atherosclerotic-vulnerable-plaque
#4
Yijin Su, Changsong Xu, Kunyu Li, Bo Wang, Jufang Chen, Long Liu, Lizhou Lin, Qingqing Dong, Lianfang Du
In the present study, we determined whether ultrasound-targeted microbubble destruction (UTMD) combined with dual targeting of transforming growth factor (TGF)-β1 and tissue inhibitors of metalloproteinase (TIMP) 1 recombinant adeno-associated virus (rAAV) can stabilize atherosclerotic vulnerable plaques. First, we used rabbit model to detect the TGF-β1/TIMP1 virus therapy result. H&E staining was used to evaluate the tissues. The protein levels of TGF-β1 and TIMP1 were detected in rabbit models. The THP-1 cells were induced into macrophages, and transfected with TGF-β1 and TIMP1 rAAV under optimized UTMD...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412421/change-in-carotid-plaque-components-a-4-year-follow-up-study-with-serial-mr-imaging
#5
Laura Pletsch-Borba, Mariana Selwaness, Aad van der Lugt, Albert Hofman, Oscar H Franco, Meike W Vernooij
OBJECTIVES: The goal of this study was to determine how carotid plaque components (e.g., intraplaque hemorrhage [IPH], calcification, lipid core) change over time and which cardiovascular risk factors are associated with the development of each component. BACKGROUND: Carotid atherosclerotic plaque components are important markers of plaque vulnerability. How these components change and which factors lead to the development and changes in the components remain unclear...
April 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28411037/carotid-plaque-evaluation-using-gemstone-spectral-imaging-comparison-with-magnetic-resonance-angiography
#6
Yuki Shinohara, Makoto Sakamoto, Keita Kuya, Junichi Kishimoto, Eijiro Yamashita, Shinya Fujii, Masamichi Kurosaki, Toshihide Ogawa
BACKGROUND: The present study compared the applicability of computed tomography carotid plaque imaging using effective Z maps with gemstone spectral imaging (GSI) to that of magnetic resonance plaque imaging using 3-dimensional time-of-flight magnetic resonance angiography. METHODS: Stenosis was assessed in 18 carotid arteries of 14 patients, and the effective Z values of noncalcified carotid plaques were compared with the signal intensities of magnetic resonance angiography...
April 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28402079/inverse-association-between-size-of-the-lipid-rich-necrotic-core-and-vascularization-in-human-carotid-plaques
#7
Ola Hjelmgren, Lars Johansson, Ulrica Prahl, Caroline Schmidt, Göran M L Bergström
PURPOSE: To study the relationship between the size of the lipid-rich necrotic core measured by MRI (magnetic resonance imaging) and the level of plaque vascularization measured by contrast-enhanced ultrasound, in human carotid plaques. Further, to compare the size of lipid-rich necrotic core from MRI to plaque echogenicity. METHODS: Thirty-one subjects with carotid plaques underwent standard B-mode ultrasound, contrast-enhanced ultrasound and MRI. The lipid-rich necrotic core was quantified using MRI...
April 12, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28397443/an-evaluation-of-dual-source-computed-tomography-used-with-the-de-weert-classification-to-detect-vulnerable-plaque-using-ivus-virtual-histology-as-a-standard-of-reference
#8
Bartosz Dołęga-Kozierowski, Piotr Klimeczek, Michał Lis, Róża Krycińska, Anna Chrapusta, Urszula Zaleska-Dorobisz, Jerzy Garcarek, Wojciech Witkiewicz
BACKGROUND: One of the main risk factors for cerebral ischemic events is atherosclerotic disease of the internal carotid artery (ICA). Nowadays, increasing attention is being paid to the relationship between the morphological features of atherosclerotic plaque and the occurrence of stroke. Several studies have demonstrated that the presence of specific vulnerable plaque types, with a large lipid core and thin fibrous cap, can be used as an independent risk predictor of cerebral ischemic events...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397162/sustained-placental-growth-factor-2-treatment-does-not-aggravate-advanced-atherosclerosis-in-ischemic-cardiomyopathy
#9
Ming Wu, Peter Pokreisz, Melissa Swinnen, Ellen Caluwe, Hilde Gillijns, Nina Vanden Driessche, Andrea Casazza, Erik Verbeken, Desire Collen, Stefan Janssens
Angiogenic growth factor therapy for ischemic cardiovascular disease carries a risk of stimulating atherosclerotic plaque growth. We evaluated risk benefit ratio of sustained administration of recombinant human placental growth factor (rhPlGF)-2 in mice with advanced atherosclerosis and chronic ischemic cardiomyopathy. We maintained apolipoprotein E-deficient mice on a high cholesterol diet and induced myocardial infarction by transient ligation at 4 weeks. At 8 weeks, we assessed left ventricular (LV) function and randomized mice to receive rhPlGF-2 or vehicle (VEH) subcutaneously for 28 days...
April 10, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28390769/vascular-applications-of-contrast-enhanced-ultrasound-imaging
#10
REVIEW
Kunal S Mehta, Jake J Lee, Ashraf A Taha, Efthymios Avgerinos, Rabih A Chaer
OBJECTIVE: Contrast-enhanced ultrasound (CEUS) imaging is a powerful noninvasive modality offering numerous potential diagnostic and therapeutic applications in vascular medicine. CEUS imaging uses microbubble contrast agents composed of an encapsulating shell surrounding a gaseous core. These microbubbles act as nearly perfect intravascular reflectors of ultrasound energy and may be used to enhance the overall contrast and quality of ultrasound images. The purpose of this narrative review is to survey the current literature regarding CEUS imaging and discuss its diagnostic and therapeutic roles in current vascular and selected nonvascular applications...
April 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28388659/identification-of-neovascularization-by-contrast-enhanced-ultrasound-to-detect-unstable-carotid-stenosis
#11
Charlotte Schmidt, Thomas Fischer, Ralph-Ingo Rückert, Timm Oberwahrenbrock, Lutz Harms, Golo Kronenberg, Hagen Kunte
BACKGROUND: Plaque neovascularization accompanies local inflammation and critically contributes to plaque instability. Correct identification of intraplaque neovascularization by contrast-enhanced ultrasound (CEUS) may provide an additional risk marker in carotid stenosis. This pilot study investigates the correlation between histological evaluation of carotid plaque specimens and pre-surgery CEUS to identify neovascularization. METHODS: 17 patients with high-grade internal carotid artery (ICA) stenosis were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28387815/atherosclerotic-plaque-vulnerability-in-the-statin-era
#12
Jan Nilsson
Life style changes and improved medical therapy have decreased cardiovascular mortality in many countries over the last decades. This has been accompanied by changes in disease characteristics including more non-ST segment elevation myocardial infraction and less vulnerable plaques as assessed by histological analysis of surgical specimens. However, many patients with established disease still suffer from recurrent cardiovascular events in spite of treatment with state-of-the-art-therapy including statins. It is likely that this reflects a state of the disease in which statins control the pro-inflammatory effects of lipids allowing other statin-unresponsive disease mechanisms to become increasingly important...
April 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28386172/angiotensin-ii-accelerated-vulnerability-of-carotid-plaque-in-a-cholesterol-fed-rabbit-model-assessed-with-magnetic-resonance-imaging-comparing-to-histopathology
#13
Beibei Sun, Huilin Zhao, Xiao Li, Hong Yao, Xiaosheng Liu, Qing Lu, Jieqing Wan, Jianrong Xu
This study sought to reveal the effect of angiotensin II (Ang II)-induced atherosclerotic vulnerability in rabbits and to determine whether in vivo magnetic resonance imaging (MRI) can determine the effect of Ang II on atherosclerotic development over time. In total, 24 elderly male New Zealand white rabbits underwent an intravascular balloon injury in the left common carotid artery (LCCA) and were subsequently fed a high cholesterol diet for 12 weeks. At 8 weeks, rabbits were randomly assigned to receive either Ang II (1...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28385307/imaging-vulnerable-plaque-a-medical-necessity-or-a-scientific-curiosity
#14
EDITORIAL
H William Strauss, Jagat Narula
No abstract text is available yet for this article.
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28360913/lectin-pathway-of-complement-activation-is-associated-with-vulnerability-of-atherosclerotic-plaques
#15
Stefano Fumagalli, Carlo Perego, Rosalia Zangari, Daiana De Blasio, Marco Oggioni, Francesca De Nigris, Francesco Snider, Peter Garred, Angela M R Ferrante, Maria-Grazia De Simoni
Inflammatory mechanisms may be involved in atherosclerotic plaque rupture. By using a novel histology-based method to quantify plaque instability here, we assess whether lectin pathway (LP) of complement activation, a major inflammation arm, could represent an index of plaque instability. Plaques from 42 consecutive patients undergoing carotid endarterectomy were stained with hematoxylin-eosin and the lipid core, cholesterol clefts, hemorrhagic content, thickness of tunica media, and intima, including or not infiltration of cellular debris and cholesterol, were determined...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28359716/pretreatment-with-and-ongoing-use-of-omega-3-fatty-acid-ethyl-esters-reduce-the-slow-flow-phenomenon-and-prevent-in-stent-restenosis-in-patients-undergoing-carotid-artery-stenting
#16
Ichiro Nakagawa, Hun Soo Park, Shohei Yokoyama, Takeshi Wada, Syuichi Yamada, Yasushi Motoyama, Kimihiko Kichikawa, Hiroyuki Nakase
OBJECTIVE: Carotid artery stenting (CAS) is a less invasive alternative to carotid endarterectomy, but it is essential to prevent thromboembolic complications during CAS and to suppress in-stent restenosis (ISR) after CAS because of the relatively high risk of periprocedural and follow-up stroke events. Clinical trials have demonstrated the strong relationship of carotid plaque vulnerability with the subsequent risk of ipsilateral ischemic stroke and thromboembolic complications during CAS...
March 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28347486/comparison-of-coronary-intimal-plaques-by-optical-coherence-tomography-in-arteries-with-versus-without-internal-running-vasa-vasorum
#17
Hideo Amano, Masayuki Koizumi, Ryo Okubo, Takayuki Yabe, Ippei Watanabe, Daiga Saito, Mikihito Toda, Takanori Ikeda
It has been reported that the internal running vasa vasorum (VV) was associated with plaque vulnerability, and microchannels in optical coherence tomography (OCT) are consistent pathologically with VV. We investigated plaque vulnerability and incidence of slow flow during percutaneous coronary intervention of the internal longitudinal running VV. Subjects were 71 lesions that underwent OCT before percutaneous coronary intervention. Internal running VV was defined as intraplaque neovessels running from the adventitia to plaque...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28345303/arterial-ageing-from-endothelial-dysfunction-to-vascular-calcification
#18
M Tesauro, A Mauriello, V Rovella, M Annicchiarico-Petruzzelli, C Cardillo, G Melino, N Di Daniele
Complex structural and functional changes occur in the arterial system with advancing age. The aged artery is characterized by changes in microRNA expression patterns, autophagy, smooth muscle cell migration and proliferation, and arterial calcification with progressively increased mechanical vessel rigidity and stiffness. With age the vascular smooth muscle cells modify their phenotype from contractile to 'synthetic' determining the development of intimal thickening as early as the second decade of life as an adaptive response to forces acting on the arterial wall...
May 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28344199/association-of-toll-like-receptor-4-on-human-monocyte-subsets-and-vulnerability-characteristics-of-coronary-plaque-as-assessed-by-64-slice-multidetector-computed-tomography
#19
Yuichi Ozaki, Toshio Imanishi, Seiki Hosokawa, Tsuyoshi Nishiguchi, Akira Taruya, Takashi Tanimoto, Akio Kuroi, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Hironori Kitabata, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka
BACKGROUND: Although Toll-like receptor 4 (TLR-4) is involved in monocyte activation in patients with accelerated forms of atherosclerosis, the relationship between the expression of TLR-4 on circulating monocytes and coronary plaque vulnerability has not previously been evaluated. We investigated this relationship using 64-slice multidetector computed tomography (MDCT) in patients with stable angina pectoris (SAP).Methods and Results:We enrolled 65 patients with SAP who underwent MDCT...
March 24, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28337456/comparison-of-the-protective-effects-of-individual-components-of-particulated-trans-sialidase-ptcts-ptc-and-ts-against-high-cholesterol-diet-induced-atherosclerosis-in-rabbits
#20
Shérrira M Garavelo, Maria de Lourdes Higuchi, Jaqueline J Pereira, Marcia M Reis, Joyce T Kawakami, Renata N Ikegami, Suely A P Palomino, Nilsa S Y Wadt, Abdelali Agouni
Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined with trans-Sialidase (TS), to combat MPs and Mycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS...
2017: BioMed Research International
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