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Vulnerable plaque

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https://www.readbyqxmd.com/read/28714527/multimodality-imaging-of-intermediate-lesions-data-from-ffr-oct-nirs-ivus
#1
Dariusz Biały, Magdalena Wawrzyńska, Jacek Arkowski, Marcin Rogała, Klaudia Proniewska, Wojciech Wańha, Wojciech Wojakowski, Tomasz Roleder
BACKGROUND: Fractional flow reserve (FFR) assesses a functional impact of the atheroma on the myocardial ischemia, but it does not take into account the morphology of the lesion. Previous optical coherence tomography (OCT), intravascular ultrasound (IVUS) and near infrared spectroscopy (NIRS) studies presented their potential to detect vulnerable plaque, which is not possible by FFR assessment. With the following study, the intermediate lesions were assessed by FFR, OCT and combined NIRS-IVUS imaging to identify plaque vulnerability...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28711401/performance-of-acoustic-radiation-force-impulse-ultrasound-imaging-for-carotid-plaque-characterization-with-histologic-validation
#2
Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Yue Wang, Hongtu Zhu, Benjamin Y Huang, Ellie R Lee, Carlos A Zamora, Mark A Farber, Joseph J Fulton, Peter F Ford, William A Marston, Raghuveer Vallabhaneni, Timothy C Nichols, Caterina M Gallippi
OBJECTIVE: Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation. METHODS: Carotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28706202/near-infrared-autofluorescence-induced-by-intraplaque-hemorrhage-and-heme-degradation-as-marker-for-high-risk-atherosclerotic-plaques
#3
Nay Min Htun, Yung Chih Chen, Bock Lim, Tara Schiller, Ghassan J Maghzal, Alex L Huang, Kirstin D Elgass, Jennifer Rivera, Hans G Schneider, Bayden R Wood, Roland Stocker, Karlheinz Peter
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28705824/carotid-plaque-morphology-and-ischemic-vascular-brain-disease-on-mri
#4
Q J A van den Bouwhuijsen, M W Vernooij, B F J Verhaaren, H A Vrooman, W J Niessen, G P Krestin, M A Ikram, O H Franco, A van der Lugt
BACKGROUND AND PURPOSE: Vulnerable carotid plaque components are reported to increase the risk of cerebrovascular events. Yet, the relation between plaque composition and subclinical ischemic brain disease is not known. We studied, in the general population, the association between carotid atherosclerotic plaque characteristics and ischemic brain disease on MR imaging. MATERIALS AND METHODS: From the population-based Rotterdam Study, 951 participants underwent both carotid MR imaging and brain MR imaging...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28704403/genetic-variants-of-ptgs2-txa2r-and-txas1-are-associated-with-carotid-plaque-vulnerability-platelet-activation-and-txa2-levels-in-ischemic-stroke-patients
#5
Xingyang Yi, Jing Lin, Hua Luo, Chun Wang, Yingying Liu
Eicosanoids may play a role in ischemic stroke. However, the associations of variants in cyclooxygenase (COX) pathway genes and interaction among these variants with carotid plaque vulnerability are not fully understood. In present study, twelve variants in COX pathway genes were examined using matrix-assisted laser desorption ionization time-of-flight mass spectrometry method in 396 patients with ischemic stroke and 291 controls. Platelet aggregation, platelet-leukocyte aggregates, and urine 11-dehydrothromboxane B2 (11-dTxB2) were also measured...
2017: PloS One
https://www.readbyqxmd.com/read/28704240/computed-tomography-angiography-defined-vulnerable-plaque-in-a-patient-with-low-high-density-lipoprotein-cholesterol-and-subsequent-myocardial-infarction
#6
Fabiana H Rached, Viviane Z Rocha, Raul D Santos, Carlos V Serrano, Adriano Caixeta
No abstract text is available yet for this article.
July 12, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28703931/rationale-and-design-of-a-randomized-trial-of-apixaban-vs-warfarin-to-evaluate-atherosclerotic-calcification-and-vulnerable-plaque-progression
#7
Kazuhiro Osawa, Rine Nakanishi, Theingi Tiffany Win, Dong Li, Sina Rahmani, Negin Nezarat, Nasim Sheidaee, Matthew J Budoff
Vitamin K antagonists (VKAs) are known to increase vascular calcification, suggesting increased cardiovascular disease events. Apixaban is an oral direct factor Xa inhibitor superior to warfarin at preventing stroke or systemic embolism and may stabilize coronary atherosclerosis. The potential benefits of avoiding VKA therapy and the favorable effects of factor Xa inhibitors could contribute to cardiovascular disease event reduction. We hypothesized that apixaban inhibits vascular calcification and coronary atherosclerosis progression compared with warfarin in patients with atrial fibrillation (AF)...
July 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28703797/dickkopf1-destabilizes-atherosclerotic-plaques-and-promotes-plaque-formation-by-inducing-apoptosis-of-endothelial-cells-through-activation-of-er-stress
#8
Mingxue Di, Lin Wang, Mengmeng Li, Yu Zhang, Xinxin Liu, Renya Zeng, Han Wang, Yifei Chen, Weijia Chen, Yun Zhang, Mei Zhang
Several clinical studies reported that Dickkopf1 (DKK1) plasma levels are correlated with atherosclerosis. However, the impact of DKK1 on the formation and vulnerability of atherosclerotic plaques remains elusive. This study investigated DKK1's effects on enlargement and destabilization of plaques by targeting endothelial cells and assessing the possible cellular mechanisms involved. The effects of DKK1 on atherogenesis and plaque stability were evaluated in ApoE-/- mice using lentivirus injections to knockdown and knock-in the DKK1 gene...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28701474/detecting-human-coronary-inflammation-by-imaging-perivascular-fat
#9
Alexios S Antonopoulos, Fabio Sanna, Nikant Sabharwal, Sheena Thomas, Evangelos K Oikonomou, Laura Herdman, Marios Margaritis, Cheerag Shirodaria, Anna-Maria Kampoli, Ioannis Akoumianakis, Mario Petrou, Rana Sayeed, George Krasopoulos, Constantinos Psarros, Patricia Ciccone, Carl M Brophy, Janet Digby, Andrew Kelion, Raman Uberoi, Suzan Anthony, Nikolaos Alexopoulos, Dimitris Tousoulis, Stephan Achenbach, Stefan Neubauer, Keith M Channon, Charalambos Antoniades
Early detection of vascular inflammation would allow deployment of targeted strategies for the prevention or treatment of multiple disease states. Because vascular inflammation is not detectable with commonly used imaging modalities, we hypothesized that phenotypic changes in perivascular adipose tissue (PVAT) induced by vascular inflammation could be quantified using a new computerized tomography (CT) angiography methodology. We show that inflamed human vessels release cytokines that prevent lipid accumulation in PVAT-derived preadipocytes in vitro, ex vivo, and in vivo...
July 12, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28698173/interferon-regulatory-factor-5-controls-necrotic-core-formation-in-atherosclerotic-lesions-by-impairing-efferocytosis
#10
Anusha N Seneviratne, Andreas O Edsfeldt, Jennifer E Cole, Christina Kassiteridi, Maarten Swart, Inhye Park, Patricia Green, Tariq E Khoyratty, David G Saliba, Michael E Goddard, Stephen N Sansom, Isabel Goncalves, Rob Krams, Irina A Udalova, Claudia Monaco
Background -Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake apoptotic cells (efferocytosis), promotes lesion growth and establishment of a necrotic core. The transcription factor Interferon Regulatory Factor (IRF)-5 is an important modulator of myeloid function and programming. We sought to investigate whether IRF5 affects the formation and phenotype of atherosclerotic lesions. Methods -We investigated the role of IRF5 in atherosclerosis in two complementary models...
July 11, 2017: Circulation
https://www.readbyqxmd.com/read/28697847/the-impact-of-serum-trans-fatty-acids-concentration-on-plaque-vulnerability-in-patients-with-coronary-artery-disease-assessment-via-optical-coherence-tomography
#11
Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Tatsuro Ishida, Hiromasa Otake, Tomofumi Takaya, Daisuke Sugiyama, Takayosi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Natsuko Tahara, Yuto Shinkura, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuichiro Nagano, Hiroyuki Yamamoto, Kenichi Yanaka, Yoshiro Tsukiyama, Ken-Ichi Hirata
BACKGROUND AND AIMS: Recent epidemiological studies have showed that excessive intake of trans fatty acids (TFA) can be a residual risk for the development of coronary artery disease (CAD) even under medical management, including statins. This study aimed at investigating the association between lipid profile, including serum TFA concentration, and plaque vulnerability using optical coherence tomography (OCT). METHODS: The level of serum elaidic acid, a major TFA component, was measured using gas chromatography in 161 consecutively enrolled patients with CAD under guideline-directed risk factor management...
June 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28692481/differences-in-coronary-plaque-characteristics-between-patients-with-and-those-without-peripheral-arterial-disease
#12
Krzysztof L Bryniarski, Erika Yamamoto, Higuma Takumi, Lei Xing, Thomas Zanchin, Tomoyo Sugiyama, Hang Lee, Ik-Kyung Jang
INTRODUCTION: Cardiovascular mortality of patients with combined peripheral arterial disease (PAD) and coronary artery disease (CAD) is twice as high as that in those with either disease alone. It is known that patients with PAD undergoing percutaneous coronary intervention have a higher incidence of adverse cardiac events such as myocardial infarction or target vessel revascularization. OBJECTIVE: In this study, we compared the detailed characteristics of culprit and nonculprit plaques between patients with and those without PAD using optical coherence tomography...
July 7, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28687781/p2x7-receptor-antagonism-modulates-il-1%C3%AE-and-mmp9-in-human-atherosclerotic-vessels
#13
Maria Lombardi, Maria Elena Mantione, Domenico Baccellieri, David Ferrara, Renata Castellano, Roberto Chiesa, Ottavio Alfieri, Chiara Foglieni
In atherosclerosis, matrix metallopeptidases (MMPs) contribute to plaque rupture through weakening of the fibrous cap. Pleiotropic P2X purinoceptor 7 (P2X7), expressed in the carotid plaque (PL), is involved in interleukin 1 beta (IL-1β) release that may influence MMP9 generation, thus their possible modulation through acting on P2X7 was investigated. P2X7-related machinery was characterized and the effects of P2X7 antagonists (A740003, KN62) and MMPs inhibitors (Batimastat, Ro28-2653) were studied in ex-vivo tissue cultures of human PL's vs...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28685252/imaging-the-event-prone-coronary-artery-plaque
#14
Andreas A Giannopoulos, Dominik C Benz, Christoph Gräni, Ronny R Buechel
Acute coronary events, the dreaded manifestation of coronary atherosclerosis, remain one of the main contributors to mortality and disability in the developed world. The majority of those events are associated with atherosclerotic plaques-related thrombus formation following an acute disruption, that being rupture or erosion, of an event-prone lesion. These historically termed vulnerable plaques have been the target of numerous benchtop and clinical research endeavors, yet to date without solid results that would allow for early identification and potential treatment...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28680156/miniature-probe-for-mapping-mechanical-properties-of-vascular-lesions-using-acoustic-radiation-force-optical-coherence-elastography
#15
Yueqiao Qu, Teng Ma, Youmin He, Mingyue Yu, Jiang Zhu, Yusi Miao, Cuixia Dai, Pranav Patel, K Kirk Shung, Qifa Zhou, Zhongping Chen
Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from harmless ones. Many methods focus on the structural or molecular properties of plaques. Mechanical properties have been shown to change drastically when abnormalities develop in arterial tissue. We report the development of an acoustic radiation force optical coherence elastography (ARF-OCE) system that uses an integrated miniature ultrasound and optical coherence tomography (OCT) probe to map the relative elasticity of vascular tissues...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677375/high-expression-of-cx3c-chemokine-receptor-1-cx3cr1-in-human-carotid-plaques-is-associated-with-vulnerability-of-the-lesions
#16
Marta Masztalewicz, Przemysław Nowacki, Łukasz Szydłowski, Maciej Żukowski, Piotr Gutowski
<i><b>Introduction</b>: In data based on ex vivo studies and animal models, fractalkine is considered an important mediator in the development and destabilization of atherosclerotic plaques. We do not know how it is associated with human carotid plaques morphology. <b>Material and methods</b>: The study included 126 carotid plaques taken from 126 patients who underwent endarterectomy of internal carotid arteries. We assessed the following characteristics: inflammatory infiltration, connective tissue elements, foam cells, lipid core, plaque vascularisation, calcifications, intraplaque haemorrhage, thrombi built into the plaque structure, and mural thrombi...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28674269/detection-of-ceramide-a-risk-factor-for-coronary-artery-disease-in-human-coronary-plaques-by-fluorescent-angioscopy
#17
Yasumi Uchida, Yasuto Uchida, Takanobu Kobayashi, Seiichiro Shirai, Nobuyuki Hiruta, Ei Shimoyama, Tsuyoshi Tabata
BACKGROUND: The presence of ceramide in human coronary plaques is a risk factor for ischemic heart disease, but its visualization in the human vessel wall is currently beyond the scope of any available imaging techniques.Methods and Results:Deposition of ceramide was examined by fluorescent angioscopy (FA) and microscopy (FM) using golden fluorescence (Go) as a specific marker of ceramide in yellow plaques, which were obtained from 23 autopsy subjects and classified by conventional angioscopy and histology...
June 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28673240/association-of-platelet-to-lymphocyte-ratio-with-non-culprit-atherosclerotic-plaque-vulnerability-in-patients-with-acute-coronary-syndrome-an-optical-coherence-tomography-study
#18
Xuedong Wang, Zulong Xie, Xinxin Liu, Xingtao Huang, Jiale Lin, Dan Huang, Bo Yu, Jingbo Hou
BACKGROUND: The platelet to lymphocyte ratio (PLR), an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome (ACS). METHODS: The patients in our study were divided into two groups (high PLR group and low PLR group). A total of 119 non-culprit plaques from 71 patients with ACS were assessed by optical coherence tomography (OCT)...
July 3, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28672747/ngal-and-mmp-9-ngal-as-biomarkers-of-plaque-vulnerability-and-targets-of-statins-in-patients-with-carotid-atherosclerosis
#19
Wolf Eilenberg, Stefan Stojkovic, Alexandra Kaider, Nicolas Kozakowski, Christoph M Domenig, Christopher Burghuber, Josif Nanobachvili, Kurt Huber, Markus Klinger, Christoph Neumayer, Ihor Huk, Johann Wojta, Svitlana Demyanets
BACKGROUND: Neutrophil gelatinase associated lipocalin (NGAL) is expressed in atherosclerotic lesions and was recently implicated in the pathogenesis of cardiovascular pathologies. Statins are known to exert stabilizing effects on atherosclerotic plaque. The aims of our study were (1) to investigate the association of serum NGAL and metalloproteinase (MMP)-9/NGAL complex with the vulnerability of the atherosclerotic plaque, and (2) to reveal the effects of statin treatment on circulating NGAL and MMP-9/NGAL levels in patients with carotid artery stenosis...
June 26, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28665970/cholesterol-crystal-depth-in-coronary-atherosclerotic-plaques-a-novel-index-of-plaque-vulnerability-using-optical-frequency-domain-imaging
#20
Masahiro Koide, Akiko Matsuo, Satoshi Shimoo, Kazuaki Takamatsu, Atsushi Kyodo, Yumika Tsuji, Kayoko Mera, Yoshinori Tsubakimoto, Koji Isodono, Tomohiko Sakatani, Keiji Inoue, Hiroshi Fujita
BACKGROUND: The involvement of cholesterol crystals (CCs) in plaque progression and destabilization of atherosclerotic plaques has been recently recognized. This study aimed to evaluate the association between the intraplaque localization of CCs and plaque vulnerability. METHODS: We investigated 55 acute coronary syndrome (ACS) and 80 stable angina pectoris (stable AP) lesions using optical frequency domain imaging (OFDI) prior to percutaneous coronary intervention...
2017: PloS One
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