keyword
MENU ▼
Read by QxMD icon Read
search

Vulnerable plaque

keyword
https://www.readbyqxmd.com/read/29792135/modified-ldl-immune-complexes-and-cardiovascular-disease
#1
Maria F Lopes-Virella, Gabriel Virella
Modified forms of LDL, both spontaneously formed in the organism or prepared in the laboratory, are immunogenic. As a consequence, antigen-antibody complexes (immune complexes, IC) formed in vivo can be measured in the peripheral blood, and their levels are strong predictors of cardiovascular disease (CVD). It has been possible to generate antibodies that recognize different LDL modifications, allowing the analysis of circulating IC constitution. Clinical studies showed that the antigenic constitution of the IC has a modulating effect on the development of CVD...
May 23, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29773990/atorvastatin-inhibits-inflammatory-response-attenuates-lipid-deposition-and-improves-the-stability-of-vulnerable-atherosclerotic-plaques-by-modulating-autophagy
#2
Shi Peng, Long-Wei Xu, Xin-Yu Che, Qing-Qing Xiao, Jun Pu, Qin Shao, Ben He
Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis and exert subsequent atheroprotective effects. Our previous study also demonstrated the role of autophagy in the inhibition of inflammation by atorvastatin in vitro . Therefore, in the present study, we aimed to determine whether atorvastatin could upregulate autophagy to inhibit inflammatory cytokines secretion, lipid accumulation, and improve vulnerable plaque stability, both in vitro and in vivo ...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29766009/persistent-buttock-claudication-after-endovascular-abdominal-aortic-aneurysm-repair
#3
Alessandro Robaldo, Stefano Pagliari, Filippo Piaggio, Patrizio Colotto
We describe the successful surgical treatment of a 71-year-old man affected by right buttock claudication after a right internal iliac artery (IIA) coil embolization as an adjunct to endovascular iliac artery aneurysm repair. Computed tomography angiography revealed extensive aortoiliac calcifications and thrombus in the vessel walls. Despite patency of the contralateral IIA and preservation of right distal collateral flow through ipsilateral hypogastric branches, the symptom was persistent and disabling. The high-risk patient underwent an "open" repair of the infrarenal abdominal aneurysm with removal of the entire stent-graft and concomitant revascularization of the right IIA...
December 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29765694/development-of-an-intravascular-ultrasound-elastography-based-on-a-dual-element-transducer
#4
Cho-Chiang Shih, Pei-Yu Chen, Teng Ma, Qifa Zhou, K Kirk Shung, Chih-Chung Huang
The ability to measure the elastic properties of plaques and vessels would be useful in clinical diagnoses, particularly for detecting a vulnerable plaque. This study demonstrates the feasibility of the combination of intravascular ultrasound (IVUS) and acoustic radiation force elasticity imaging for detecting the distribution of stiffness within atherosclerotic arteries ex vivo . A dual-frequency IVUS transducer with two elements was used to induce the propagation of the shear wave (by the 8.5 MHz pushing element) which could be simultaneously monitored by the 31 MHz imaging element...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29761981/-plaque-segmentation-of-intracoronary-optical-coherence-tomography-images-based-on-k-means-and-improved-random-walk-algorithm
#5
Guanglei Wang, Pengyu Wang, Yechen Han, Xiuling Liu, Yan Li, Qian Lu
In recent years, optical coherence tomography (OCT) has developed into a popular coronary imaging technology at home and abroad. The segmentation of plaque regions in coronary OCT images has great significance for vulnerable plaque recognition and research. In this paper, a new algorithm based on K -means clustering and improved random walk is proposed and Semi-automated segmentation of calcified plaque, fibrotic plaque and lipid pool was achieved. And the weight function of random walk is improved. The distance between the edges of pixels in the image and the seed points is added to the definition of the weight function...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29760458/hyperglycemia-does-not-affect-tissue-repair-responses-in-shear-stress-induced-atherosclerotic-plaques-in-apoe-mice
#6
Sabrina Hsiung, Anki Knutsson, Jenifer Vallejo, Pontus Dunér, Suvi E Heinonen, Ann-Cathrine Jönsson-Rylander, Eva Bengtsson, Jan Nilsson, Anna Hultgårdh-Nilsson
The mechanisms responsible for macrovascular complications in diabetes remain to be fully understood. Recent studies have identified impaired vascular repair as a possible cause of plaque vulnerability in diabetes. This notion is supported by observations of a reduced content of fibrous proteins and smooth muscle cell mitogens in carotid endarterectomy from diabetic patients along with findings of decreased circulating levels of endothelial progenitor cells. In the present study we used a diabetic mouse model to characterize how hyperglycemia affects arterial repair responses...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29754669/comparison-of-fractional-flow-reserve-and-intravascular-ultrasound-guided-intervention-strategy-for-clinical-outcomes-in-patients-with-intermediate-stenosis-flavour-rationale-and-design-of-a-randomized-clinical-trial
#7
Jeehoon Kang, Bon-Kwon Koo, Xinyang Hu, Joo Myung Lee, Joo-Yong Hahn, Hyoung-Mo Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Chul Ahn, JianAn Wang, Seung-Jae Tahk
BACKGROUND: Coronary angiography has limitations in defining the ischemia-causing stenotic lesion, especially in cases with intermediate coronary stenosis. Fractional flow reserve (FFR) is a current standard method to define the presence of ischemia, and intravascular ultrasound (IVUS) is the most commonly used invasive imaging tool that can provide the lesion geometry and can provide the information on plaque vulnerability. The primary aim of this study is to compare the safety and efficacy of FFR-guided and IVUS-guided percutaneous coronary intervention (PCI) strategies in patients with intermediate coronary stenosis...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29753613/atherosclerosis-is-an-epigenetic-disease
#8
Suowen Xu, Jaroslav Pelisek, Zheng Gen Jin
Atherosclerosis is a chronic inflammatory and lipid-depository disease that eventually leads to acute cardiovascular events. Emerging evidence supports that epigenetic processes such as DNA methylation, histone modification, and noncoding RNAs play an important role in plaque progression and vulnerability, highlighting the therapeutic potential of epigenetic drugs in cardiovascular therapeutics.
May 9, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29751284/association-of-skin-autofluorescence-with-plaque-vulnerability-evaluated-by-optical-coherence-tomography-in-patients-with-cardiovascular-disease
#9
Yusuke Fujino, Guilherme F Attizzani, Satoko Tahara, Wei Wang, Kensuke Takagi, Toru Naganuma, Hiroto Yabushita, Kentaro Tanaka, Tomohiko Sato, Yusuke Watanabe, Satoru Mitomo, Naoyuki Kurita, Hisaaki Ishiguro, Shotaro Nakamura, Koji Hozawa, Hiram G Bezerra, Sho-Ichi Yamagishi, Sunao Nakamura
BACKGROUND AND AIMS: Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. METHODS: We prospectively enrolled 108 patients with CVD, who underwent OCT images during percutaneous coronary intervention (PCI)...
March 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29735336/dose-dependent-inhibitory-effect-of-rosuvastatin-in-japanese-patients-with-acute-myocardial-infarction-on-serum-concentration-of-matrix-metalloproteinases-invitation-trial
#10
Koichiro Fujisue, Takuhiro Shirakawa, Shinichi Nakamura, Nobuyasu Yamamoto, Shuichi Oshima, Toshiyuki Matsumura, Ryusuke Tsunoda, Nobutaka Hirai, Shinji Tayama, Natsuki Nakamura, Toyoki Hirose, Hideki Maruyama, Kazuteru Fujimoto, Ichiro Kajiwara, Tomohiro Sakamoto, Koichi Nakao, Naritsugu Sakaino, Seiji Hokimoto, Yasuhiro Nagayoshi, Jun Hokamaki, Hideki Shimomura, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Koichi Kaikita, Hisao Ogawa, Kenichi Tsujita
BACKGROUND: Acute myocardial infarction (AMI) is mainly characterized by the rupture of lipid-rich vulnerable atherosclerotic plaque. The matrix metalloproteinases (MMPs) have been shown to play a critical role in inflammatory processes underlying plaque rupture. Some reports suggested statins inhibit the increased MMP levels after AMI. However, there are a few comparison studies between the different dosages of the same statin and circulating levels of MMPs. PURPOSE: This study will preliminarily investigate the potential effects of appropriate or low dose of rosuvastatin on circulating MMPs levels in AMI patients...
May 4, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29735317/risk-marker-variability-in-subclinical-carotid-plaques-based-on-ultrasound-is-influenced-by-cardiac-phase-echogenicity-and-size
#11
Emma Nyman, Per Lindqvist, Ulf Näslund, Christer Grönlund
Identification of risk markers based on quantitative ultrasound texture analysis of carotid plaques has the ability to define vulnerable components that correlate with increased cardiovascular risk. However, data describing factors with the potential to influence the measurement variability of risk markers are limited. The aim of this study was to evaluate the influence of electrocardiogram-guided image selection, plaque echogenicity and area on carotid plaque risk markers and their variability in asymptomatic carotid plaques...
May 4, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29729869/plasma-trimethylamine-n-oxide-is-associated-with-vulnerable-plaque-characteristics-in-cad-patients-as-assessed-by-optical-coherence-tomography
#12
Xinxin Liu, Zulong Xie, Meng Sun, Xuedong Wang, Ji Li, Jinjin Cui, Fengyun Zhang, Li Yin, Dan Huang, Jingbo Hou, Jinwei Tian, Bo Yu
BACKGROUND: Plaque vulnerability indicates the risk of a cardiovascular event. In the present study, we sought to analyze the relationship between trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, and vulnerable plaque characteristics in patients with coronary artery disease (CAD). METHODS: One hundred eighty non-culprit plaques from 90 patients with ACS or with stable angina were assessed by optical coherence tomography (OCT)...
April 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29707133/interactions-among-variants-in-txa2r-p2y12-and-gpiiia-are-associated-with-carotid-plaque-vulnerability-in-chinese-population
#13
Xingyang Yi, Jing Lin, Hua Luo, Ju Zhou, Qiang Zhou, Yanfen Wang, Chun Wang
Purpose: The associations between variants in platelet activation-relevant genes and carotid plaque vulnerability are not fully understood. The aim of the present study was to investigate the associations of the variants in platelet activation-relevant genes and interactions among these variants with carotid plaque vulnerability. Results: There were no significant differences in the frequencies of genotypes of the 11 variants between patients and controls. Among 396 patients, 102 patients had not carotid plaque, 106 had VP, and 188 had SP...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29704490/mathematical-modeling-of-atherosclerotic-plaque-destabilization-role-of-neovascularization-and-intraplaque-hemorrhage
#14
Muyi Guo, Yan Cai, Xinke Yao, Zhiyong Li
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the quantitative evaluation of the role of neoangiogenesis and IPH in the vulnerable atherosclerotic plaque formation. An angiogenic microvasculature is generated by two-dimensional nine-point discretization of endothelial cell proliferation and migration from the vasa vasorum...
April 25, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29695169/association-of-prediabetes-with-higher-coronary-atherosclerotic-burden-among-patients-with-first-diagnosed-acute-coronary-syndrome
#15
Burak Açar, Ozcan Ozeke, Mustafa Karakurt, Yasin Ozen, Mustafa Bilal Özbay, Sefa Unal, Mustafa Karanfil, Cagri Yayla, Serkan Cay, Orhan Maden, Serkan Topaloğlu, Dursun Aras, Zehra Golbasi, Sinan Aydogdu
Diabetes mellitus (DM) is associated with more extensive coronary atherosclerosis and more vulnerable plaque phenotypes. However, DM should not be considered a homogeneous and purely binary entity in terms of risk assessment. We evaluated the impact of prediabetic status on coronary atherosclerosis burden in patients with first-time acute coronary syndrome (ACS) who underwent urgent coronary angiography. The patients were divided into DM, prediabetes, and control groups. The 3-vessel disease (TVD) rates and SYNTAX and Gensini scoring systems for defining atherosclerotic burden were compared...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29689466/reconstruction-of-optical-absorption-coefficient-distribution-in-intravascular-photoacoustic-imaging
#16
Sun Zheng, Zheng Lan
Intravascular photoacoustic (IVPA) imaging can discriminate between normal arterial tissues and atheromatous plaques in images, particularly images of lipid-rich plaques with high spatial resolution and optical contrast. However, conventional IVPA only recovers the deposited optical energy that is the product of the tissue optical absorption coefficient and local optical fluence. Herein, a one-step model-based method for single-wavelength IVPA imaging system is proposed. The proposed method directly reconstructs the optical absorption coefficient from the boundary measurement of acoustic pressure...
April 21, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29685689/insulin-resistance-adipocyte-derived-exosomes-aggravate-atherosclerosis-by-increasing-vasa-vasorum-angiogenesis-in-diabetic-apoe-mice
#17
Feng Wang, Fang-Fang Chen, Yuan-Yuan Shang, Ya Li, Zhi-Hao Wang, Lu Han, Yi-Hui Li, Lei Zhang, Yun Ti, Wei Zhang, Ming Zhong
BACKGROUND: Vasa vasorum (VV) angiogenesis is increased in type 2 diabetes mellitus (T2DM) and may promote atherosclerotic plaque rupture. We sought to determine whether insulin resistance adipocyte-derived exosomes (IRADEs) played a major role in modulating VV angiogenesis and the mechanisms involved. METHODS: The characterization of IRADEs was performed by electron microscopy, NTA (Nanoparticle Tracking Analysis) and western blot. The cellular effects of IRADEs on angiogenesis were explored in human umbilical vein endothelial cells (HUVECs) and murine aortic endothelial cells (MAECs) in vitro...
April 9, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29684582/platelet-microparticle-delivered-microrna-let-7a-promotes-the-angiogenic-switch
#18
Chinedu Anene, Anne M Graham, James Boyne, Wayne Roberts
Platelet microparticle (PMP)-induced angiogenesis plays a key role in tumour metastasis and has been proposed to contribute towards cardiovascular disease by enhancing atherosclerotic plaque vulnerability. However, the mechanisms underlying PMP induced angiogenesis are ill defined. Recent reports demonstrate that PMPs deliver micro-RNAs (miRNAs) to recipient cells, controlling gene expression. We therefore evaluated whether miRNA transfer was a key regulator of PMP-induced angiogenesis. Co-culturing PMPs with human umbilical vein endothelial cells (HUVEC) on extracellular matrix gel induced robust capillary like structure formation...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#19
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29675417/developing-a-reliable-mouse-model-for-cancer-therapy-induced-cardiovascular-toxicity-in-cancer-patients-and-survivors
#20
Kyung Ae Ko, Yin Wang, Sivareddy Kotla, Yuka Fujii, Hang Thi Vu, Bhanu P Venkatesulu, Tamlyn N Thomas, Jan L Medina, Young Jin Gi, Megumi Hada, Jane Grande-Allen, Zarana S Patel, Sarah A Milgrom, Sunil Krishnan, Keigi Fujiwara, Jun-Ichi Abe
Background: The high incidence of cardiovascular events in cancer survivors has long been noted, but the mechanistic insights of cardiovascular toxicity of cancer treatments, especially for vessel diseases, remain unclear. It is well known that atherosclerotic plaque formation begins in the area exposed to disturbed blood flow, but the relationship between cancer therapy and disturbed flow in regulating plaque formation has not been well studied. Therefore, we had two goals for this study; (1) Generate an affordable, reliable, and reproducible mouse model to recapitulate the cancer therapy-induced cardiovascular events in cancer survivors, and (2) Establish a mouse model to investigate the interplay between disturbed flow and various cancer therapies in the process of atherosclerotic plaque formation...
2018: Frontiers in Cardiovascular Medicine
keyword
keyword
79318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"