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Plaque rupture

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https://www.readbyqxmd.com/read/28642677/a-novel-workflow-combining-plaque-imaging-plaque-and-plasma-proteomics-identifies-biomarkers-of-human-coronary-atherosclerotic-plaque-disruption
#1
Regent Lee, Roman Fischer, Philip D Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K Kharbanda, Robin P Choudhury, Charalambos Antoniades, Benedikt M Kessler, Keith M Channon
BACKGROUND: Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding and clinical management of patients presenting with possible acute vascular syndromes but such biomarker(s) remain elusive. Investigation of biomarkers in the context of de novo plaque rupture in humans is confounded by the inability to attribute the plaque rupture as the source of biomarker release, as plaque ruptures are typically associated with prompt down-stream events of myocardial necrosis and systemic inflammation...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28642174/elevated-scd40l-mmp-9-and-mmp-2-is-associated-with-carotid-plaque-vulnerability-in-patients-with-ischemic-cerebrovascular-disease
#2
Yipeng Han, Xiang Mao, Lijun Wang, Jiachun Liu, Daming Wang, Hongwei Cheng, Guozhuan Miao
OBJECTIVES: The objectives of this study were to examine the correlation between the level of serum inflammatory markers and the stability of carotid plaques in patients with ischemic cerebrovascular disease and to assess the ability of each inflammatory marker to identify vulnerable carotid plaques. METHODS: for the Early Identification of Vulnerable Carotid Plaques Sixty-five patients with carotid plaques were divided into a stable plaque group (n = 21) and an unstable plaque group (n = 44) according to MRI characteristics...
June 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28637952/heat-shock-protein-72-promotes-platelet-aggregation-induced-by-various-platelet-activators-in-rats
#3
Hideaki Suzuki, Yuuko Kosuge, Koji Kobayashi, Yoshifumi Kurosaki, Naohito Ishii, Naoyoshi Aoyama, Kazuhiko Ishihara, Takafumi Ichikawa
Increase of thrombus in the coronary arteries is positively correlated with the level of heat-shock protein 72 (HSP72) in the blood of patients with acute myocardial infarction (AMI). Platelet aggregation participates in thrombus formation on ruptured plaque in AMI. In this study, we aimed to clarify the role of HSP72 in thrombus formation by evaluating the effects of HSP72 on platelet aggregation. Platelet aggregation activities were measured in platelet-rich plasma obtained from male Sprague-Dawley rats with or without the platelet activators, such as adenosine diphosphate (ADP), collagen, thrombin receptor-activating peptide-6 (TRAP-6), ristocetin, and arachidonic acid...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28635311/type-d-personality-but-not-type-a-behavior-pattern-is-associated-with-coronary-plaque-vulnerability
#4
Ping Lin, Ling Li, Yini Wang, Zhenjuan Zhao, Guojie Liu, Wei Chen, Hui Tao, Xueqin Gao
Personality traits are associated with major adverse coronary events (MACE) in patients with coronary artery disease (CAD). However, the link between personality traits and intravascular morphology in CAD patients is poorly understood. This study investigated the relationship between personality traits, specifically Type A behavior pattern and Type D personality, and plaque vulnerability. After adjustment for demographic and clinical factors, multivariable regression analysis showed no association between Type A and optical coherence tomography indices...
June 21, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28632493/interplay-between-papp-a-inflammation-and-adiposity-in-patients-with-angiographically-proven-acute-coronary-syndrome-acs
#5
Khageshwar Mahato, Moushumi Lodh, Ashok Parida, Ashok Kr Ahirwar, Rashmi Rasi Datta, Binita Goswami
Introduction Studies conducted in the recent past have demonstrated the role of inflammation, obesity and dysfunctional insulin signaling as contributing factors in the pathogenesis of acute coronary syndrome (ACS). However, pharmacological interventions targeting a single pathway have not proven useful in the long run. This indicates that a synergism occurs between the various risk factors and hence calls for a combinatorial approach. This study was planned to study the interplay, if any, between pregnancy associated plasma protein-A (PAPP-A), inflammation and adiposity in patients with ACS...
June 21, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28624816/circulating-micrornas-as-potential-biomarkers-for-coronary-plaque-rupture
#6
Sufang Li, Chongyou Lee, Junxian Song, Changlin Lu, Jun Liu, Yuxia Cui, Huizhu Liang, Chengfu Cao, Feng Zhang, Hong Chen
Coronary plaque rupture is the most common cause of acute coronary syndrome. However, the timely biomarker-based diagnosis of plaque rupture remains a major unmet clinical challenge. Balloon dilatation and stent implantation during percutaneous coronary intervention (PCI) could cause plaque injury and rupture. Here we aimed to assess the possibility of circulating microRNAs (miRNAs) as biomarkers of acute coronary plaque rupture by virtue of the natural model of PCI-induced plaque rupture. Stable coronary artery disease patients underwent PCI with single stent implantation were recruited and a three-phase approach was conducted in the present study: (i) profiling of plasma miRNAs in a group of patients before (0 h) and after balloon dilatation for 1 h (1 h vs...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615715/rnaseq-based-transcriptomics-study-of-smcs-from-carotid-atherosclerotic-plaque-bmp2-and-ids-proteins-are-crucial-regulators-of-plaque-stability
#7
Iraide Alloza, Haize Goikuria, Juan Luis Idro, Juan Carlos Triviño, José María Fernández Velasco, Elena Elizagaray, María García-Barcina, Genoveva Montoya-Murillo, Esther Sarasola, Reyes Vega Manrique, Maria Del Mar Freijo, Koen Vandenbroeck
Carotid artery atherosclerosis is a risk factor to develop cerebrovascular disease. Atheroma plaque can become instable and provoke a cerebrovascular event or else remain stable as asymptomatic type. The exact mechanism involved in plaque destabilization is not known but includes among other events smooth muscle cell (SMC) differentiation. The goal of this study was to perform thorough analysis of gene expression differences in SMCs isolated from carotid symptomatic versus asymptomatic plaques. Comparative transcriptomics analysis of SMCs based on RNAseq technology identified 67 significant differentially expressed genes and 143 significant differentially expressed isoforms in symptomatic SMCs compared with asymptomatic...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615442/the-heterotrimeric-g-protein-g%C3%AE-1-interacts-with-the-catalytic-subunit-of-protein-phosphatase-1-and-modulates-g-protein-coupled-receptor-signaling-in-platelets
#8
Subhashree Pradhan, Tanvir Khatlani, Angus C Nairn, K Vinod Vijayan
Thrombosis is caused by the activation of platelets at the site of ruptured atherosclerotic plaques. This activation involves engagement of G protein coupled receptors (GPCR) on platelets that promotes their aggregation. Although it is known that protein kinases and phosphatases modulate GPCR signaling, how serine/threonine phosphatases integrate with G protein signaling pathways is less understood. Since the subcellular localization and substrate specificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dictated by PP1c-interacting proteins, here we sought to identify new PP1c interactors...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28608182/an-unmet-clinical-need-the-history-of-thrombus-imaging
#9
Gregory M Lanza, Grace Cui, Anne H Schmieder, Huiying Zhang, John S Allen, Michael J Scott, Todd Williams, Xiaoxia Yang
Robust thrombus imaging is an unresolved clinical unmet need dating back to the mid 1970s. While early molecular imaging approaches began with nuclear SPECT imaging, contrast agents for virtually all biomedical imaging modalities have been demonstrated in vivo with unique strengths and common weaknesses. Two primary molecular imaging targets have been pursued for thrombus imaging: platelets and fibrin. Some common issues noted over 40 years ago persist today. Acute thrombus is readily imaged with all probes and modalities, but aged thrombus remains a challenge...
June 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28607546/histologic-sequelae-of-apical-hypertrophic-cardiomyopathy-dystrophic-calcification
#10
Shahryar G Saba, John N Makaryus, Navid Rahmani, Ram Jadonath
We present cardiac computed tomography (CT) findings demonstrating apical hypertrophic cardiomyopathy with dystrophic calcification of the left ventricular apex. The absence of significant epicardial coronary artery disease demonstrated by coronary CT angiography suggests that increased wall tension and decreased microvascular perfusion over time account for the dyskinetic apical myocardium, rather than myocardial infarction secondary to atherosclerotic plaque rupture. These observations support CT as the imaging modality of choice to visualize the deposition of calcium in injured myocardial tissue, a recognized occurrence in chronically infarcted myocardium...
2017: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/28605473/effects-of-statins-on-plaque-rupture-assessed-by-optical-coherence-tomography-in-patients-presenting-with-acute-coronary-syndromes-insights-from-the-optical-coherence-tomography-oct-formidable-registry
#11
Sebastiano Gili, Mario Iannaccone, Francesco Colombo, Antonio Montefusco, Nicolas Amabile, Simone Calcagno, Davide Capodanno, Giancarla Scalone, Andrea Rognoni, Pierluigi Omedè, Fabrizio Ugo, Erika Cavallo, Massimo Mancone, Andrea Mangiameli, Giacomo Boccuzzi, Joshua Hiansen, Pascal Motreff, Konstantinos Toutouzas, Roberto Garbo, Gennaro Sardella, Corrado Tamburino, Maurizio D'Amico, Claudio Moretti, Christian Templin, Fiorenzo Gaita, Geraud Souteyrand, Giampaolo Niccoli, Fabrizio D'Ascenzo
Aims: Chronic pre-treatment with statins may reduce mortality and morbidity in patients experiencing acute coronary syndromes (ACS), but mechanisms accounting for these findings are not completely understood. Methods and results: The optical coherence tomography (OCT)-Formidable registry retrospectively enrolled 285 consecutive patients with ACS undergoing OCT in 9 European centres. Mean age was 60.4 ± 12.8 years, 148 (51.9%) patients had hyperlipemia, 45 (15...
June 10, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28602809/potential-of-%C3%AE-7-nachr-pet-imaging-in-atherosclerosis
#12
REVIEW
P F Ellen Boswijk, Matthias Bauwens, Felix M Mottaghy, Joachim E Wildberger, Jan Bucerius
Atherosclerotic events are usually acute and often strike otherwise asymptomatic patients. Although multiple clinical risk factors have been associated with atherosclerosis up to date, no further individual prediction can be made as to who will acutely suffer from its consequences based on traditional imaging methods like CT, MRI or angiography, or biomarkers. Previously, non-invasive imaging with (18)F-fluorodeoxyglucose ((18)F-FDG) PET was shown to potentially fill this niche as it offers high sensitive detection of metabolic processes associated with inflammatory changes in atherosclerotic plaques...
June 7, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28602267/post-reconstruction-dermatitis-of-the-breast
#13
A C Rosen, C Goh, M E Lacouture, B J Mehrara, P G Cordeiro, P L Myskowski
BACKGROUND: Approximately one-third of women diagnosed with breast cancer undergo mastectomy with subsequent implant-based or autogenous tissue-based reconstruction. Potential complications include infection, capsular contracture, and leak or rupture of implants with necessity for explantation. Skin rashes are infrequently described complications of patients who undergo mastectomy with or without reconstruction. METHODS: A retrospective analysis of breast cancer patients referred to the Dermatology Service for diagnosis and management of a rash post-mastectomy and expander or implant placement or transverse rectus abdominis myocutaneous (TRAM) flap reconstruction was performed...
May 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28601467/recurrent-acute-coronary-syndrome-and-mechanisms-of-plaque-instability
#14
Luca Di Vito, Giampaolo Niccoli, Italo Porto, Rocco Vergallo, Laura Gatto, Francesco Prati, Filippo Crea
Patients with an acute coronary syndrome (ACS) due to plaque rupture had a worse prognosis when compared with those without plaque rupture with a higher rate of target vessel revascularization and readmission for unstable angina, suggesting that both stent failure and disease progression occur more frequently. However, it is not known whether recurrent episodes of coronary instability in the same patient are caused by the same pathogenetic mechanism. Thus, we sought to investigate the mechanisms of coronary instability imaged by optical coherence tomography in patients with recurrent ACS events...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28597906/platelet-receptors-as-therapeutic-targets-past-present-and-future
#15
Janina Jamasbi, Keng Ayabe, Shinya Goto, Bernhard Nieswandt, Karlheinz Peter, Wolfgang Siess
Anti-platelet drugs reduce arterial thrombosis after plaque rupture and erosion, prevent stent thrombosis and are used to prevent and treat myocardial infarction and ischaemic stroke. Some of them may also be helpful in treating less frequent diseases such as thrombotic thrombocytopenic purpura. The present concise review aims to cover current and future developments of anti-platelet drugs interfering with the interaction of von Willebrand factor (VWF) with glycoprotein (GP) Ibα, and directed against GPVI, GPIIb/IIIa (integrin αIIbβ3), the thrombin receptor PAR-1, and the ADP receptor P2Y12...
June 8, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28594051/antithrombotic-therapy-for-acute-coronary-syndrome-past-present-and-future
#16
Dirk Sibbing, Dominick J Angiolillo, Kurt Huber
Plaque erosions and ruptures are the histopathological hallmarks of arterial thrombus formation in the coronary arteries. The clinical condition associated with this process is usually referred to as acute coronary syndrome (ACS). Importantly, both blood platelets and the coagulation cascade are key players for initiation, amplification and perpetuation of ACS. There has been great progress in ACS treatment in recent decades, both at the technical level of (percutaneous) revascularisation and at the level of antithrombotic treatment...
June 8, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28584227/quantitative-analysis-of-lipid-rich-necrotic-core-in-carotid-atherosclerotic-plaques-by-in-vivo-magnetic-resonance-imaging-and-clinical-outcomes
#17
Jun Xia, Anyu Yin, Zhenzhou Li, Xin Liu, Xianghong Peng, Ni Xie
BACKGROUND The aim of this study was to explore the accuracy of in vivo magnetic resonance imaging (MRI) in the quantitative evaluation of lipid-rich necrotic core (LRNC) in carotid atherosclerotic plaques compared with histopathology, and to assess the association of LRNC size with cerebral ischemia symptoms. MATERIAL AND METHODS Thirty patients were enrolled and 19 patients (16 men and 3 women) were analyzed. All the patients were submitted to MRI on a Siemens Avanto (1.5-Tesla) device before carotid endarterectomy (CEA)...
June 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28574044/-autotransplantation-of-the-internal-carotid-artery-in-patients-with-high-localization-of-an-atherosclerotic-plaque
#18
E V Rosseĭkin, A B Voevodin, D A Radzhabov, V V Bazylev
Acute and chronic cerebral circulatory impairment is a very commonly encountered type of neurological diseases, annually affecting more than six million people worldwide. The absolute majority of all cases are associated with atherosclerosis of cerebral arteries. Surgical intervention in a stenotic lesion of the internal carotid artery (ICA) is a method of preventive treatment with confirmed efficacy. Eversion carotid endarterectomy (ECEA) is currently the most commonly used 'open' operation for this cohort of patients...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28559142/ag1296-enhances-plaque-stability-via-inhibiting-inflammatory-responses-and-decreasing-mmp-2-and-mmp-9-expression-in-apoe-mice
#19
Min Dong, Changping Zhou, Liang Ji, Bing Pan, Lemin Zheng
BACKGROUND: Atherosclerosis is a chronic process that progresses to unstable plaques. Plaque rupture leads to deleterious consequences such as acute coronary syndrome, thrombosis and stroke. AG1296 is a potent tyrosine kinase inhibitor which is able to block PDGF-PDGFR signaling pathway. This study aims to assess the effect of AG1296 on plaque stability and explore the potential mechanisms. METHODS: Atherosclerotic plaques were induced in carotid arteries in ApoE-/- mice by perivascular collar placement...
May 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28556893/a-component-by-component-characterisation-of-high-risk-atherosclerotic-plaques-by-multiphoton-microscopic-imaging
#20
M Jain, B Wu, D Pisapia, S Salvatore, S Mukherjee, N Narula
AIMS: Atherosclerotic plaques vulnerable to rupture are almost always inflamed, and carry a large lipid core covered by a thin fibrous cap. The other components may include neovascularisation, intraplaque haemorrhage and spotty calcification. In contrast, stable plaques are characterised by a predominance of smooth muscle cells and collagen, and lipid core is usually deep seated or absent. This study is a proof of principle experiment to evaluate the feasibility of multiphoton microscopy (MPM) to identify aforementioned plaque components...
May 30, 2017: Journal of Microscopy
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