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https://www.readbyqxmd.com/read/28746820/the-role-of-damps-and-pamps-in-inflammation-mediated-vulnerability-of-atherosclerotic-plaques
#1
Vikrant Rai, Devendra K Agrawal
Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streak and progress through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia, hyperglycemia are the risk factors for atherosclerosis. Inflammation, infection with viruses and bacteria, and dysregulation in the endothelial and vascular smooth muscle cells leads to advanced plaque formation...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28738484/-correlation-between-serum-inflammatory-cytokine-levels-and-fibrous-cap-thickness-of-fibrofatty-plaque-in-coronary-culprit-lesions
#2
Y Zhong, F Ye, W You, Z M Wu
Objective: To identify the correlation between serum inflammatory cytokine levels including high sensitive C reactive protein (hs-CRP) and lipoprotein associated phospholipase (Lp-PLA2) and the fibrous cap thickness of fibrofatty plaque in coronary culprit lesions. Methods: Clinical data of 117 patients with selective coronary artery angiography diagnosed coronary artery disease admitted to our hospital from January 2015 to January 2016 were retrospective analyzed. According to type of coronary disease, patients were divided into 3 subgroups: SAP group (containing 47 stable angina patients), UAP group (containing 52 unstable angina patients), and NSTEMI group(containing 18 acute non ST segment elevation myocardial infarction patients)...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28736079/model-based-cap-thickness-and-peak-cap-stress-prediction-for-carotid-mri
#3
Annette M Kok, Aad van der Lugt, Hence J M Verhagen, Antonius F W van der Steen, Jolanda J Wentzel, Frank J H Gijsen
A rupture-prone carotid plaque can potentially be identified by calculating the peak cap stress (PCS). For these calculations, plaque geometry from MRI is often used. Unfortunately, MRI is hampered by a low resolution, leading to an overestimation of cap thickness and an underestimation of PCS. We developed a model to reconstruct the cap based on plaque geometry to better predict cap thickness and PCS. We used histological stained plaques from 34 patients. These plaques were segmented and served as the ground truth...
July 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28735837/coronary-artery-calcification-from-crystal-to-plaque-rupture
#4
REVIEW
Loïc Panh, Olivier Lairez, Jean-Bernard Ruidavets, Michel Galinier, Didier Carrié, Jean Ferrières
Epidemiological studies using coronary artery calcification measurement have linked calcification strongly with coronary events and mortality. Formerly considered as a passive age-related phenomenon, coronary artery calcification is now recognized as an active and regulated process. In fact, there is a local influence linked to the inflammation generated by the presence of oxidized lipids and, equally, a general influence from mineral metabolism factors, such as inorganic phosphate, calcium, pyrophosphate or fibroblast growth factor 23, which are regulators of cell differentiation and of phosphate and calcium deposition on the vascular layers...
July 20, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28734914/the-ongoing-quest-to-predict-plaque%C3%A2-rupture
#5
EDITORIAL
Habib Samady, David S Molony
No abstract text is available yet for this article.
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734913/uncovered-culprit-plaque-ruptures-in-patients-with-st-segment-elevation-myocardial-infarction-assessed-by-optical-coherence-tomography-and-intravascular-ultrasound-with-imap
#6
Mikkel Hougaard, Henrik Steen Hansen, Per Thayssen, Lisbeth Antonsen, Lisette Okkels Jensen
OBJECTIVES: This study assessed the incidence and course of healing of uncovered plaque ruptures (PR) following primary percutaneous coronary intervention. BACKGROUND: The infarct-related occlusion is frequently located at the lesion site with maximum thrombus burden, whereas the culprit PR may be situated more proximally or distally. METHODS: Uncovered PR in segments adjacent to the stent were identified by optical coherence tomography and intravascular ultrasound using iMap (Boston Scientific, Marlborough, Massachusetts) within 48 h and after 12 months...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734911/plaque-rupture-in-coronary-atherosclerosis-is-associated-with-increased-plaque-structural-stress
#7
Charis Costopoulos, Yuan Huang, Adam J Brown, Patrick A Calvert, Stephen P Hoole, Nick E J West, Jonathan H Gillard, Zhongzhao Teng, Martin R Bennett
OBJECTIVES: The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. BACKGROUND: Plaque rupture is the most common cause of myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound-virtual histology studies indicate that <10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque rupture...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28732809/oleacein-may-inhibit-destabilization-of-carotid-plaques-from-hypertensive-patients-impact-on-high-mobility-group-protein-1
#8
Agnieszka Filipek, Monika E Czerwińska, Anna K Kiss, Jerzy A Polański, Marek Naruszewicz
BACKGROUND: In patients with hypertension the haemorrhage into carotid atherosclerotic plaque increases risk of plaque destabilization and rupture. Our previous study showed that oleacein, a secoiridoid present in extra virgin olive oil, enhanced uptake of haemoglobin-haptoglobin complex and change macrophage phenotype from pro-inflammatory M1 to anti-inflammatory M2. PURPOSE: The aim this study was to investigate a potential role of oleacein in attenuation of carotid plaque destabilisation ex vivo...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28731023/an-extinct-volcano-a-stable-ruptured-coronary-plaque-shown-by-oct-imaging
#9
Giampiero Vizzari, Alessandro DI Giorgio, Giuseppe Andò, Francesco Saporito
No abstract text is available yet for this article.
October 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28715441/mri-based-patient-specific-human-carotid-atherosclerotic-vessel-material-property-variations-in-patients-vessel-location-and-long-term-follow-up
#10
Qingyu Wang, Gador Canton, Jian Guo, Xiaoya Guo, Thomas S Hatsukami, Kristen L Billiar, Chun Yuan, Zheyang Wu, Dalin Tang
BACKGROUND: Image-based computational models are widely used to determine atherosclerotic plaque stress/strain conditions and investigate their association with plaque progression and rupture. However, patient-specific vessel material properties are in general lacking in those models, limiting the accuracy of their stress/strain measurements. A noninvasive approach of combining in vivo 3D multi-contrast and Cine magnetic resonance imaging (MRI) and computational modeling was introduced to quantify patient-specific carotid plaque material properties for potential plaque model improvements...
2017: PloS One
https://www.readbyqxmd.com/read/28711401/performance-of-acoustic-radiation-force-impulse-ultrasound-imaging-for-carotid-plaque-characterization-with-histologic-validation
#11
Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Yue Wang, Hongtu Zhu, Benjamin Y Huang, Ellie R Lee, Carlos A Zamora, Mark A Farber, Joseph J Fulton, Peter F Ford, William A Marston, Raghuveer Vallabhaneni, Timothy C Nichols, Caterina M Gallippi
OBJECTIVE: Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation. METHODS: Carotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28707263/delivery-of-viral-vectors-for-gene-therapy-in-intimal-hyperplasia-and-restenosis-in-atherosclerotic-swine
#12
REVIEW
Sannette Hall, Devendra K Agrawal
Cardiovascular diseases including atherosclerosis are a major financial and health burden globally. Inflammation associated with atherosclerosis results in the development of plaques that can rupture causing thrombosis, stroke, or death. The most widely used treatment for the removal of atherosclerotic plaques is percutaneous transluminal coronary angioplasty (PTCA) with or without stenting. Although this is a safer and minimally invasive method, restenosis and intimal hyperplasia after interventional procedure remains a major hurdle and more refined approaches are needed...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28699262/recurrent-myocardial-infarction-in-a-47-year-old-woman-with-a-mechanical-mitral-valve-prosthesis-atherosclerosis-embolism-or-spasm
#13
Bimmer E Claessen, Thomas P W van den Boogert, Jan J Piek
We present a case of a 47-year-old woman with a mechanical mitral valve prosthesis and recurrent myocardial infarction. The most common etiology of spontaneous myocardial infarction is an acute coronary syndrome caused by rupture or erosion of an atherosclerotic plaque. However, the differential diagnosis in the patient described below also included infarction due to embolization or coronary spasm. It can be challenging to discriminate between the different causes of myocardial infarction based on interpretation of symptoms, physical examination, laboratory tests, and electrocardiography alone...
July 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28699188/culprit-plaque-characteristics-in-younger-versus-older-patients-with-acute-coronary-syndromes-an-optical-coherence-tomography-study-from-the-formidable-registry
#14
Umberto Barbero, Paolo Scacciatella, Mario Iannaccone, Fabrizio D'Ascenzo, Giampaolo Niccoli, Francesco Colombo, Fabrizio Ugo, Salvatore Colangelo, Massimo Mancone, Calcagno Simone, Gennaro Sardella, Nicolas Amabile, Pascal Motreff, Konstantinos Toutouzas, Roberto Garbo, Corrado Tamburino, Antonio Montefusco, Pierluigi Omedè, Claudio Moretti, Maurizio D'amico, Geraud Souteyrand, Fiorenzo Gaita, Christian Templin
OBJECTIVES: Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. METHODS: Patients were divided in two groups according to age at presentation: juvenile-ACS (age ≤ 50 years) and not juvenile-ACS (age > 50 years)...
July 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28695757/association-between-snoring-and-high-risk-carotid-plaque-features
#15
Erin M Kirkham, Thomas S Hatsukami, Susan R Heckbert, Jie Sun, Gador Canton, Chun Yuan, Edward M Weaver
Objectives Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke. Study Design Cross-sectional. Setting Tertiary care university hospital and affiliated county hospital. Methods We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high-resolution MRI...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28693506/intracellular-high-cholesterol-content-disorders-the-clock-genes-apoptosis-related-genes-and-fibrinolytic-related-genes-rhythmic-expressions-in-human-plaque-derived-vascular-smooth-muscle-cells
#16
Changpo Lin, Xiao Tang, Lirong Xu, Ruizhe Qian, Zhenyu Shi, Lixin Wang, Tingting Cai, Dong Yan, Weiguo Fu, Daqiao Guo
BACKGROUND: The clock genes are involved in regulating cardiovascular functions, and their expression disorders would lead to circadian rhythm disruptions of clock-controlled genes (CCGs), resulting in atherosclerotic plaque formation and rupture. Our previous study revealed the rhythmic expression of clock genes were attenuated in human plaque-derived vascular smooth muscle cells (PVSMCs), but failed to detect the downstream CCGs expressions and the underlying molecular mechanism. In this study, we examined the difference of CCGs rhythmic expression between human normal carotid VSMCs (NVSMCs) and PVSMCs...
July 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28689783/immune-complexes-containing-malondialdehyde-mda-ldl-induce-apoptosis-in-human-macrophages
#17
Gabriel Virella, Kelsey Wilson, Johnathon Elkes, Samar M Hammad, Hussein A Rajab, Yanchun Li, Charlyne Chassereau, Yan Huang, Maria Lopes-Virella
Immune complexes (IC) containing predominantly malondialdehyde-LDL and the corresponding autoantibodies (MDA-LDL IC) predict acute cardiovascular events, while IC rich in oxidized LDL (oxLDL IC) predict cardiovascular disease progression. Our objective was to determine mechanisms that could explain these prognostic differences. We compared the effects of the interaction of oxLDL, MDA-LDL and the corresponding IC with human macrophages focusing on apoptosis, metalloproteinases, and proinflammatory cytokines...
July 6, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28687781/p2x7-receptor-antagonism-modulates-il-1%C3%AE-and-mmp9-in-human-atherosclerotic-vessels
#18
Maria Lombardi, Maria Elena Mantione, Domenico Baccellieri, David Ferrara, Renata Castellano, Roberto Chiesa, Ottavio Alfieri, Chiara Foglieni
In atherosclerosis, matrix metallopeptidases (MMPs) contribute to plaque rupture through weakening of the fibrous cap. Pleiotropic P2X purinoceptor 7 (P2X7), expressed in the carotid plaque (PL), is involved in interleukin 1 beta (IL-1β) release that may influence MMP9 generation, thus their possible modulation through acting on P2X7 was investigated. P2X7-related machinery was characterized and the effects of P2X7 antagonists (A740003, KN62) and MMPs inhibitors (Batimastat, Ro28-2653) were studied in ex-vivo tissue cultures of human PL's vs...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686117/predicting-ischemic-stroke-after-carotid-artery-stenting-based-on-proximal-calcification-and-the-jellyfish-sign
#19
Nobuhiko Ichinose, Seiji Hama, Toshio Tsuji, Zu Soh, Hideaki Hayashi, Yoshihiro Kiura, Shigeyuki Sakamoto, Takahito Okazaki, Daizo Ishii, Katsuhiro Shinagawa, Kaoru Kurisu
OBJECTIVE Carotid artery stenting (CAS) has been considered to prevent ischemic strokes caused by stenosis of the cervical carotid artery. The most common complication of CAS is new cerebral infarction. The authors have previously reported that the jellyfish sign-the rise and fall of the mobile component of the carotid plaque surface detected by carotid ultrasonography-suggests thinning and rupture of the fibrous cap over the unstable plaque content, such as the lipid-rich necrotic core or internal plaque hemorrhage...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28685252/imaging-the-event-prone-coronary-artery-plaque
#20
Andreas A Giannopoulos, Dominik C Benz, Christoph Gräni, Ronny R Buechel
Acute coronary events, the dreaded manifestation of coronary atherosclerosis, remain one of the main contributors to mortality and disability in the developed world. The majority of those events are associated with atherosclerotic plaques-related thrombus formation following an acute disruption, that being rupture or erosion, of an event-prone lesion. These historically termed vulnerable plaques have been the target of numerous benchtop and clinical research endeavors, yet to date without solid results that would allow for early identification and potential treatment...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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