Mathilde Delebarre, Fanny Gonzales, Hélène Behal, Aude Tiphaine, Hélène Sudour-Bonnange, Anne Lutun, Samuel Abbou, Sophie Pertuisel, Sandrine Thouvenin-Doulet, Isabelle Pellier, Ludovic Mansuy, Christophe Piguet, Catherine Paillard, Laurence Blanc, Estelle Thebaud, Dominique Plantaz, Pascale Blouin, Pascale Schneider, Cécile Guillaumat, Pauline Simon, Carine Domenech, Hélène Pacquement, Marion Le Meignen, Claire Pluchart, Cécile Vérite, Geneviève Plat, Alain Martinot, Alain Duhamel, François Dubos
BACKGROUND: In 2017, international guidelines proposed new management of febrile neutropenia in children with cancer, adapted to the risk of severe infection by clinical decision rules (CDRs). Until now, none of the proposed CDRs has performed well enough in high-income countries for use in clinical practice. Our study aimed to build and validate a new CDR (DISCERN-FN) to predict the risk of severe infection in children with febrile neutropenia. METHODS: We did two prospective studies...
April 2022: Lancet Child & Adolescent Health