keyword
https://read.qxmd.com/read/38518065/thioredoxins-o1-and-h2-jointly-adjust-mitochondrial-dihydrolipoamide-dehydrogenase-dependent-pathways-towards-changing-environments
#1
JOURNAL ARTICLE
Stefan Timm, Nicole Klaas, Janice Niemann, Kathrin Jahnke, Saleh Alseekh, Youjun Zhang, Paulo V L Souza, Liang-Yu Hou, Maike Cosse, Jennifer Selinski, Peter Geigenberger, Danilo M Daloso, Alisdair R Fernie, Martin Hagemann
Thioredoxins (TRXs) are central to redox regulation, modulating enzyme activities to adapt metabolism to environmental changes. Previous research emphasized mitochondrial and microsomal TRX o1 and h2 influence on mitochondrial metabolism, including photorespiration and the tricarboxylic acid (TCA) cycle. Our study aimed to compare TRX-based regulation circuits towards environmental cues mainly affecting photorespiration. Metabolite snapshots, phenotypes and CO2 assimilation were compared among single and multiple TRX mutants in the wild-type and the glycine decarboxylase T-protein knockdown (gldt1) background...
March 22, 2024: Plant, Cell & Environment
https://read.qxmd.com/read/38397087/the-structure-of-the-cardiac-mitochondria-respirasome-is-adapted-for-the-%C3%AE-oxidation-of-fatty-acids
#2
REVIEW
Alexander V Panov
It is well known that in the heart and kidney mitochondria, more than 95% of ATP production is supported by the β-oxidation of long-chain fatty acids. However, the β-oxidation of fatty acids by mitochondria has been studied much less than the substrates formed during the catabolism of carbohydrates and amino acids. In the last few decades, several discoveries have been made that are directly related to fatty acid oxidation. In this review, we made an attempt to re-evaluate the β-oxidation of long-chain fatty acids from the perspectives of new discoveries...
February 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38367920/pm-2-5-induces-cardiac-defects-via-ahr-sirt1-pgc-1%C3%AE-mediated-mitochondrial-damage
#3
JOURNAL ARTICLE
Jin Chen, Mingxuan Zhang, Stanley Aniagu, Yan Jiang, Tao Chen
Recent evidence indicates that PM2.5 poses a risk for congenital heart diseases, but the mechanisms remain unclear. We hypothesized that AHR activated by PM2.5 might cause mitochondrial damage via PGC-1α dysregulation, leading to heart defects. We initially discovered that the PGC-1α activator ZLN005 counteracted cardiac defects in zebrafish larvae exposed to EOM (extractable organic matter) from PM2.5 . Moreover, ZLN005 attenuated EOM-induced PGC-1α downregulation, mitochondrial dysfunction/biogenesis, and apoptosis...
February 15, 2024: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/38354740/slc25a51-decouples-the-mitochondrial-nad-nadh-ratio-to-control-proliferation-of-aml-cells
#4
JOURNAL ARTICLE
Mu-Jie Lu, Jonathan Busquets, Valeria Impedovo, Crystal N Wilson, Hsin-Ru Chan, Yu-Tai Chang, William Matsui, Stefano Tiziani, Xiaolu A Cambronne
SLC25A51 selectively imports oxidized NAD+ into the mitochondrial matrix and is required for sustaining cell respiration. We observed elevated expression of SLC25A51 that correlated with poorer outcomes in patients with acute myeloid leukemia (AML), and we sought to determine the role SLC25A51 may serve in this disease. We found that lowering SLC25A51 levels led to increased apoptosis and prolonged survival in orthotopic xenograft models. Metabolic flux analyses indicated that depletion of SLC25A51 shunted flux away from mitochondrial oxidative pathways, notably without increased glycolytic flux...
February 13, 2024: Cell Metabolism
https://read.qxmd.com/read/38245795/amifostine-ameliorates-bleomycin-induced-murine-pulmonary-fibrosis-via-nad-sirt1-ampk-pathway-mediated-effects-on-mitochondrial-function-and-cellular-metabolism
#5
JOURNAL ARTICLE
Feng Guo, Feng Xu, Shujuan Li, Yun Zhang, Dan Lv, Lin Zheng, Yongxiong Gan, Miao Zhou, Keyu Zhao, Shuling Xu, Bin Wu, Zaichun Deng, Panfeng Fu
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disease characterized by irreversible scarring of the lung parenchyma. Despite various interventions aimed at mitigating several different molecular aspects of the disease, only two drugs with limited clinical efficacy have so far been approved for IPF therapy. OBJECTIVE: We investigated the therapeutic efficacy of amifostine, a detoxifying drug clinically used for radiation-caused cytotoxicity, in bleomycin-induced murine pulmonary fibrosis...
January 20, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38195766/metabolic-imaging-of-human-embryos-is-predictive-of-ploidy-status-but-is-not-associated-with-clinical-pregnancy-outcomes-a-pilot-trial
#6
JOURNAL ARTICLE
Denny Sakkas, Colwyn Gulliford, Goli Ardestani, Olcay Ocali, Marion Martins, Nitya Talasila, Jaimin S Shah, Alan S Penzias, Emily A Seidler, Tim Sanchez
STUDY QUESTION: Does fluorescence lifetime imaging microscopy (FLIM)-based metabolic imaging assessment of human blastocysts prior to frozen transfer correlate with pregnancy outcomes? SUMMARY ANSWER: FLIM failed to distinguish consistent patterns in mitochondrial metabolism between blastocysts leading to pregnancy compared to those that did not. WHAT IS KNOWN ALREADY: FLIM measurements provide quantitative information on NAD(P)H and flavin adenine dinucleotide (FAD+) concentrations...
January 9, 2024: Human Reproduction
https://read.qxmd.com/read/38187759/effects-of-aging-on-glucose-and-lipid-metabolism-in-mice
#7
Evan C Lien, Ngoc Vu, Anna M Westermark, Laura V Danai, Allison N Lau, Yetiş Gültekin, Matthew A Kukurugya, Bryson D Bennett, Matthew G Vander Heiden
Aging is accompanied by multiple molecular changes that contribute to aging-associated pathologies, such as accumulation of cellular damage and mitochondrial dysfunction. Tissue metabolism can also change with age, in part because mitochondria are central to cellular metabolism. Moreover, the co-factor NAD + , which is reported to decline across multiple tissue types during aging, plays a central role in metabolic pathways such as glycolysis, the tricarboxylic acid cycle, and the oxidative synthesis of nucleotides, amino acids, and lipids...
December 18, 2023: bioRxiv
https://read.qxmd.com/read/38176418/mitochondria-derived-reactive-oxygen-species-are-the-likely-primary-trigger-of-mitochondrial-retrograde-signaling-in-arabidopsis
#8
JOURNAL ARTICLE
Kasim Khan, Huy Cuong Tran, Berivan Mansuroglu, Pinar Önsell, Stefano Buratti, Markus Schwarzländer, Alex Costa, Allan G Rasmusson, Olivier Van Aken
Besides their central function in respiration, plant mitochondria play a crucial role in maintaining cellular homeostasis during stress by providing "retrograde" feedback to the nucleus. Despite the growing understanding of this signaling network, the nature of the signals that initiate mitochondrial retrograde regulation (MRR) in plants remains unknown. Here, we investigated the dynamics and causative relationship of a wide range of mitochondria-related parameters for MRR, using a combination of Arabidopsis fluorescent protein biosensor lines, in vitro assays, and genetic and pharmacological approaches...
December 28, 2023: Current Biology: CB
https://read.qxmd.com/read/38159589/overweight-during-development-dysregulates-cellular-metabolism-and-critical-genes-that-control-food-intake-in-the-prefrontal-cortex
#9
JOURNAL ARTICLE
Severina Cassia de Andrade Silva, Maria Daniele Teixeira de Lemos, Osmar Henrique Dos Santos Junior, Thyago Oliveira Rodrigues, Tercya Lucidi Silva, Aline Isabel da Silva, Jarlei Fiamoncini, Claudia J Lagranha
BACKGROUNDS AND AIMS: Childhood obesity is increasing substantially across the world. The World Obesity Federation (WOF) and World Health Organization (WHO) predicted that in 2030 more than 1 billion people will be obese, and by 2035 over 4 billion will reach obesity worldwide. According to WHO, the world soon cannot afford the economic cost of obesity, and we need to act to stop obesity acceleration now. Data in the literature supports that the first 1000 days of life are essential in preventing obesity and related adversities...
December 28, 2023: Physiology & Behavior
https://read.qxmd.com/read/38129330/mitochondrial-impairment-decreased-sirtuin-activity-and-protein-acetylation-in-dorsal-root-ganglia-in-friedreich-ataxia-models
#10
JOURNAL ARTICLE
Arabela Sanz-Alcázar, Elena Britti, Fabien Delaspre, Marta Medina-Carbonero, Maria Pazos-Gil, Jordi Tamarit, Joaquim Ros, Elisa Cabiscol
Friedreich ataxia (FA) is a rare, recessive neuro-cardiodegenerative disease caused by deficiency of the mitochondrial protein frataxin. Mitochondrial dysfunction, a reduction in the activity of iron-sulfur enzymes, iron accumulation, and increased oxidative stress have been described. Dorsal root ganglion (DRG) sensory neurons are among the cellular types most affected in the early stages of this disease. However, its effect on mitochondrial function remains to be elucidated. In the present study, we found that in primary cultures of DRG neurons as well as in DRGs from the FXNI151F mouse model, frataxin deficiency resulted in lower activity and levels of the electron transport complexes, mainly complexes I and II...
December 21, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38106550/oxidative-stress-epigenetic-regulation-and-pathological-processes-of-lens-epithelial-cells-underlying-diabetic-cataract
#11
REVIEW
Zaoxia Guo, Xiaopan Ma, Rui Xue Zhang, Hong Yan
BACKGROUND: Cataract is a blinding disease worldwide. It is an age-related disease that mainly occurs in people over 65 years old. Cataract is also prevalent in patients with diabetes mellites (DM). The pathological mechanisms underlying diabetic cataract (DC) are more complex than that of age-related cataract. Studies have identified that polyol pathway, advanced glycation end products (AGEs) and oxidative stress are the primary pathogenesis of DC. In recent years, molecular-level regulations and pathological processes of lens epithelial cells (LECs) have been confirmed to play roles in the initiation and progression of DC...
2023: Adv Ophthalmol Pract Res
https://read.qxmd.com/read/38077825/platelets-of-covid-19-patients-display-mitochondrial-dysfunction-oxidative-stress-and-energy-metabolism-failure-compatible-with-cell-death
#12
JOURNAL ARTICLE
Valentine Léopold, Osoul Chouchane, Joe M Butler, Alex R Schuurman, Erik H A Michels, Justin de Brabander, Bauke V Schomakers, Michel van Weeghel, Daisy I Picavet-Havik, Anita E Grootemaat, Renée A Douma, Tom D Y Reijnders, Augustijn M Klarenbeek, Brent Appelman, W Joost Wiersinga, Nicole N van der Wel, Jeroen den Dunnen, Riekelt H Houtkooper, Cornelis Van't Veer, Tom van der Poll
BACKGROUND: Alterations in platelet function have been implicated in the pathophysiology of COVID-19 since the beginning of the pandemic. While early reports linked hyperactivated platelets to thromboembolic events in COVID-19, subsequent investigations demonstrated hyporeactive platelets with a procoagulant phenotype. Mitochondria are important for energy metabolism and the function of platelets. OBJECTIVES: Here, we sought to map the energy metabolism of platelets in a cohort of noncritically ill COVID-19 patients and assess platelet mitochondrial function, activation status, and responsiveness to external stimuli...
October 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38017373/igf2-deficiency-promotes-liver-aging-through-mitochondrial-dysfunction-and-upregulated-cebpb-signaling-in-d-galactose-induced-aging-mice
#13
JOURNAL ARTICLE
Xiaohai Zhou, Bowen Tan, Weiwei Gui, Caiping Zhou, Hanxin Zhao, Xihua Lin, Hong Li
BACKGROUND: Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease and worsens its prognosis. Insulin-like growth factor 2 (IGF2) has been implicated in numerous aging-related diseases. Nevertheless, its role and underlying molecular mechanisms in liver aging remain largely unexplored. METHODS: The expression of IGF2 was examined in the liver of young (2-4 months), middle-aged (9-12 months), and old (24-26 months) C57BL/6 mice...
November 28, 2023: Molecular Medicine
https://read.qxmd.com/read/38001340/cell-specific-modulation-of-mitochondrial-respiration-and-metabolism-by-the-pro-apoptotic-bcl-2-family-members-bax-and-bak
#14
JOURNAL ARTICLE
Dana Sovilj, Cristina Daniela Kelemen, Sarka Dvorakova, Renata Zobalova, Helena Raabova, Jan Kriska, Zuzana Hermanova, Tomas Knotek, Miroslava Anderova, Pavel Klener, Vlada Filimonenko, Jiri Neuzil, Ladislav Andera
Proteins from the Bcl-2 family play an essential role in the regulation of apoptosis. However, they also possess cell death-unrelated activities that are less well understood. This prompted us to study apoptosis-unrelated activities of the Bax and Bak, pro-apoptotic members of the Bcl-2 family. We prepared Bax/Bak-deficient human cancer cells of different origin and found that while respiration in the glioblastoma U87 Bax/Bak-deficient cells was greatly enhanced, respiration of Bax/Bak-deficient B lymphoma HBL-2 cells was slightly suppressed...
November 24, 2023: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/37967727/high-fat-high-fructose-diet-and-alpha-ketoglutarate-affect-mouse-behavior-that-is-accompanied-by-changes-in-oxidative-stress-response-and-energy-metabolism-in-the-cerebral-cortex
#15
JOURNAL ARTICLE
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B Storey, Maria Bayliak, Volodymyr I Lushchak
BACKGROUND: High caloric diets with high amounts of fats and sweeteners such as fructose may predispose organisms to neurodegenerative diseases. METHODS: This study aimed to examine the effects of a high-fat high-fructose diet (HFFD) on the behavior of mice, energy metabolism, and markers of oxidative stress in murine cerebral cortex. Dietary α-ketoglutarate (AKG) was chosen as a treatment which could modulate the putative effects of HFFD. RESULTS: We found that HFFD stimulated locomotion and defecation in mice, whereas an AKG-supplemented diet had a proclivity to promote anxiety-like behavior...
January 2024: Biochimica et Biophysica Acta. General Subjects
https://read.qxmd.com/read/37878010/mitochondrial-translocase-tomm22-is-overexpressed-in-pancreatic-cancer-and-promotes-aggressive-growth-by-modulating-mitochondrial-protein-import-and-function
#16
JOURNAL ARTICLE
Mary Oluwadamilola Haastrup, Kunwar Somesh Vikramdeo, Shashi Anand, Mohammad Aslam Khan, James Elliot Carter, Seema Singh, Ajay Pratap Singh, Santanu Dasgupta
Pancreatic cancer has the worst prognosis among all cancers underscoring the need for improved management strategies. Dysregulated mitochondrial function is a common feature in several malignancies, including pancreatic cancer. Although mitochondria have their own genome, most mitochondrial proteins are nuclear-encoded and imported by a multi-subunit translocase of the outer mitochondrial membrane (TOMM). TOMM22 is the central receptor of the TOMM complex and plays a role in complex assembly. Pathobiological roles of TOMM subunits remain largely unexplored...
October 25, 2023: Molecular Cancer Research: MCR
https://read.qxmd.com/read/37813964/the-malate-shuttle-detoxifies-ammonia-in-exhausted-t-cells-by-producing-2-ketoglutarate
#17
JOURNAL ARTICLE
Nina Weisshaar, Sicong Ma, Yanan Ming, Alaa Madi, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Kerstin Mohr, Nora Ten Bosch, Diana Stichling, Michael Buettner, Gernot Poschet, Glynis Klinke, Michael Schulz, Nina Kunze-Rohrbach, Carolin Kerber, Isabel Madeleine Klein, Jingxia Wu, Xi Wang, Guoliang Cui
The malate shuttle is traditionally understood to maintain NAD+ /NADH balance between the cytosol and mitochondria. Whether the malate shuttle has additional functions is unclear. Here we show that chronic viral infections induce CD8+ T cell expression of GOT1, a central enzyme in the malate shuttle. Got1 deficiency decreased the NAD+ /NADH ratio and limited antiviral CD8+ T cell responses to chronic infection; however, increasing the NAD+ /NADH ratio did not restore T cell responses. Got1 deficiency reduced the production of the ammonia scavenger 2-ketoglutarate (2-KG) from glutaminolysis and led to a toxic accumulation of ammonia in CD8+ T cells...
October 9, 2023: Nature Immunology
https://read.qxmd.com/read/37671592/human-ovarian-aging-is-characterized-by-oxidative-damage-and-mitochondrial-dysfunction
#18
JOURNAL ARTICLE
Myrthe A J Smits, Bauke V Schomakers, Michel van Weeghel, Eric J M Wever, Rob C I Wüst, Frederike Dijk, Georges E Janssens, Mariëtte Goddijn, Sebastiaan Mastenbroek, Riekelt H Houtkooper, Geert Hamer
STUDY QUESTION: Are human ovarian aging and the age-related female fertility decline caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER: We found oxidative damage in oocytes of advanced maternal age, even at the primordial follicle stage, and confirmed mitochondrial dysfunction in such oocytes, which likely resulted in the use of alternative energy sources. WHAT IS KNOWN ALREADY: Signs of reactive oxygen species-induced damage and mitochondrial dysfunction have been observed in maturing follicles, and even in early stages of embryogenesis...
September 6, 2023: Human Reproduction
https://read.qxmd.com/read/37650111/complex-i-deficiency-in-m-3243a-g-fibroblasts-is-alleviated-by-reducing-nadh-accumulation
#19
JOURNAL ARTICLE
Tongling Liufu, Haiyan Yu, Jiaxi Yu, Meng Yu, Yue Tian, Yichun Ou, Jianwen Deng, Guogang Xing, Zhaoxia Wang
Introduction: Mitochondrial disease is a spectrum of debilitating disorders caused by mutations in the mitochondrial DNA (mtDNA) or nuclear DNA that compromises the respiratory chain. Mitochondrial 3243A>G (m.3243 A>G) is the most common mutation showing great heterogeneity in phenotype. Previous studies have indicated that NADH: ubiquinone oxidoreductase (complex I) deficiency accompanied by a decreased nicotinamide adenine dinucleotide (NAD+ )/reduced NAD+ (NADH) ratio may play a pivotal role in the pathogenesis of m...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37565250/maternal-hepatic-adaptations-during-obese-pregnancy-encompass-lobe-specific-mitochondrial-alterations-and-oxidative-stress
#20
JOURNAL ARTICLE
Luís F Grilo, João D Martins, Mariana S Diniz, Carolina Tocantins, Chiara H Cavallaro, Inês Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W Nathanielsz, Paulo J Oliveira, Susana P Pereira
Maternal obesity(MO) is rising worldwide, affecting half of all gestations, constituting a risk-factor for pregnancy-associated liver diseases (PALD) and hepatic diseases. PALD occur in approximately 3% of pregnancies and are characterized by maternal hepatic oxidative stress(OS) and mitochondrial dysfunction. Understanding the role of MO on liver function and pathophysiology could be crucial for understanding the altered pathways leading to PALD and liver disease. We investigated specific hepatic metabolic alterations in mitochondria and oxidative stress during MO at late-gestation...
August 10, 2023: Clinical Science (1979-)
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