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myocardial endothelial cell and angiogenesis

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https://www.readbyqxmd.com/read/29457790/cd163-macrophages-promote-angiogenesis-and-vascular-permeability-accompanied-by-inflammation-in-atherosclerosis
#1
Liang Guo, Hirokuni Akahori, Emanuel Harari, Samantha L Smith, Rohini Polavarapu, Vinit Karmali, Fumiyuki Otsuka, Rachel L Gannon, Ryan E Braumann, Megan H Dickinson, Anuj Gupta, Audrey L Jenkins, Michael J Lipinski, Johoon Kim, Peter Chhour, Paul S de Vries, Hiroyuki Jinnouchi, Robert Kutys, Hiroyoshi Mori, Matthew D Kutyna, Sho Torii, Atsushi Sakamoto, Cheol Ung Choi, Qi Cheng, Megan L Grove, Mariem A Sawan, Yin Zhang, Yihai Cao, Frank D Kolodgie, David P Cormode, Dan E Arking, Eric Boerwinkle, Alanna C Morrison, Jeanette Erdmann, Nona Sotoodehnia, Renu Virmani, Aloke V Finn
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage function with respect to angiogenesis, vascular permeability, inflammation, and plaque progression...
February 19, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29452461/angiogenesis-precedes-cardiomyocyte-migration-in-regenerating-mammalian-hearts
#2
Arnar B Ingason, Andrew B Goldstone, Michael J Paulsen, Akshara D Thakore, Vi N Truong, Bryan B Edwards, Anahita Eskandari, Tanner Bollig, Amanda N Steele, Y Joseph Woo
OBJECTIVE: Although the mammalian heart's ability to fully regenerate is debated, its potential to extensively repair itself is gaining support. We hypothesized that heart regeneration relies on rapid angiogenesis to support myocardial regrowth and sought to characterize the timeline for angiogenesis and cell proliferation in regeneration. METHODS: One-day-old CD-1 mice (P1, N = 60) underwent apical resection or sham surgery. Hearts were explanted at serial time points from 0 to 30 days postresection and analyzed with immunohistochemistry to visualize vessel ingrowth and cardiomyocyte migration into the resected region...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29450744/high-density-lipoprotein-hdl-promotes-angiogenesis-via-s1p3-dependent-vegfr2-activation
#3
Fengyan Jin, Nina Hagemann, Li Sun, Jiang Wu, Thorsten R Doeppner, Yun Dai, Dirk M Hermann
High-density lipoprotein (HDL) has previously been shown to promote angiogenesis. However, the mechanisms by which HDL enhances the formation of blood vessels remain to be defined. To address this, the effects of HDL on the proliferation, transwell migration and tube formation of human umbilical vein endothelial cells were investigated. By examining the abundance and phosphorylation (i.e., activation) of the vascular endothelial growth factor receptor VEGFR2 and modulating the activity of the sphingosine-1 phosphate receptors S1P1-3 and VEGFR2, we characterized mechanisms controlling angiogenic responses in response to HDL exposure...
February 15, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29425847/-all-in-one-in%C3%A2-vitro-selection-of-collagen-binding-vascular-endothelial-growth-factor
#4
Shin-Hye Park, Takanori Uzawa, Fumiyuki Hattori, Shuichi Ogino, Naoki Morimoto, Satoshi Tsuneda, Yoshihiro Ito
To enhance the therapeutic effect of growth factors, a powerful strategy is to direct their localization to damaged sites. To treat skin wounds and myocardial infarction, we selected vascular endothelial growth factor (VEGF) carrying binding affinity to collagen. A simple conjugation of a reported collagen-binding sequence and VEGF did not increase the collagen-binding affinity, indicating that the molecular interaction between the two proteins abolished collagen binding activity. Here, we present a new molecular evolution strategy, "all-in-one" in vitro selection, in which a collagen-binding VEGF (CB-VEGF) was directly identified from a random library consisting of random and VEGF sequences...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29407886/noncanonical-nf-%C3%AE%C2%BAb-signaling-in-microvessels-of-atherosclerotic-lesions-is-associated-with-inflammation-atheromatous-plaque-morphology-and-myocardial-infarction
#5
Chrissta X Maracle, Rabia Agca, Boy Helder, John A L Meeuwsen, Hans W M Niessen, Erik A L Biessen, Menno P J de Winther, Saskia C A de Jager, Mike T Nurmohamed, Sander W Tas
BACKGROUND AND AIMS: Neovascularization is associated with atherosclerotic plaque instability and increased chance of myocardial infarction (MI). Patients with chronic inflammatory diseases (CID) have increased risk of atherosclerosis, and evidence demonstrates that NF-κB inducing kinase (NIK)-mediated noncanonical NF-κB signaling in endothelial cells (EC) is linked to inflammation and angiogenesis. Here, we hypothesized NIK may also be activated in EC of atherosclerotic lesion microvessels...
January 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29371594/endothelial-deletion-of-ino80-disrupts-coronary-angiogenesis-and-causes-congenital-heart-disease
#6
Siyeon Rhee, Jae I Chung, Devin A King, Gaetano D'amato, David T Paik, Anna Duan, Andrew Chang, Danielle Nagelberg, Bikram Sharma, Youngtae Jeong, Maximilian Diehn, Joseph C Wu, Ashby J Morrison, Kristy Red-Horse
During development, the formation of a mature, well-functioning heart requires transformation of the ventricular wall from a loose trabecular network into a dense compact myocardium at mid-gestation. Failure to compact is associated in humans with congenital diseases such as left ventricular non-compaction (LVNC). The mechanisms regulating myocardial compaction are however still poorly understood. Here, we show that deletion of the Ino80 chromatin remodeler in vascular endothelial cells prevents ventricular compaction in the developing mouse heart...
January 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29352190/autophagy-promotes-msc-mediated-vascularization-in-cutaneous-wound-healing-via-regulation-of-vegf-secretion
#7
Y An, W J Liu, P Xue, Y Ma, L Q Zhang, B Zhu, M Qi, L Y Li, Y J Zhang, Q T Wang, Y Jin
Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent differentiation capacities, have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs transplantation could largely improve cutaneous wound healing via paracrine secretion of growth factors. However, whether MSCs take part in the angiogenesis process directly remains elusive. Previous study proved that autophagy inhibited immunosuppressive function of MSCs and prevented the degradation of MSCs function in inflammatory and senescent microenvironment...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29351307/doxycycline-modulates-vegf-a-expression-failure-of-doxycycline-inducible-lentivirus-shrna-vector-to-knockdown-vegf-a-expression-in-transgenic-mice
#8
Mari Merentie, Riina Rissanen, Line Lottonen-Raikaslehto, Jenni Huusko, Erika Gurzeler, Mikko P Turunen, Lari Holappa, Petri Mäkinen, Seppo Ylä-Herttuala
Vascular endothelial growth factor-A (VEGF-A) is the master regulator of angiogenesis, vascular permeability and growth. However, its role in mature blood vessels is still not well understood. To better understand the role of VEGF-A in the adult vasculature, we generated a VEGF-A knockdown mouse model carrying a doxycycline (dox)-regulatable short hairpin RNA (shRNA) transgene, which silences VEGF-A. The aim was to find the critical level of VEGF-A reduction for vascular well-being in vivo. In vitro, the dox-inducible lentiviral shRNA vector decreased VEGF-A expression efficiently and dose-dependently in mouse endothelial cells and cardiomyocytes...
2018: PloS One
https://www.readbyqxmd.com/read/29306791/empagliflozin-rescues-diabetic-myocardial-microvascular-injury-via-ampk-mediated-inhibition-of-mitochondrial-fission
#9
Hao Zhou, Shuyi Wang, Pingjun Zhu, Shunying Hu, Yundai Chen, Jun Ren
Impaired cardiac microvascular function contributes to diabetic cardiovascular complications although effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor recently approved for treatment of type 2 diabetes, promotes glycosuria excretion and offers cardioprotective actions beyond its glucose-lowering effects. This study was designed to evaluate the effect of empagliflozin on cardiac microvascular injury in diabetes and the underlying mechanism involved with a focus on mitochondria...
December 30, 2017: Redox Biology
https://www.readbyqxmd.com/read/29281806/stem-cell-inspired-secretome-rich-injectable-hydrogel-to-repair-injured-cardiac-tissue
#10
Renae Waters, Perwez Alam, Settimio Pacelli, Aparna R Chakravarti, Rafeeq P H Ahmed, Arghya Paul
The objective of this study was to develop an injectable and biocompatible hydrogel that can deliver a cocktail of therapeutic biomolecules (secretome) secreted by human adipose-derived stem cells (hASCs) to the peri-infarct myocardium. Gelatin and Laponite® were combined to formulate a shear-thinning, nanocomposite hydrogel (nSi Gel) as an injectable carrier of secretome (nSi Gel+). The growth factor composition and the pro-angiogenic activity of the secretome were tested in vitro by evaluating the proliferation, migration and tube formation of human umbilical endothelial cells...
December 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29243842/exosomes-secreted-by-hypoxic-cardiosphere-derived-cells-enhance-tube-formation-and-increase-pro-angiogenic-mirna
#11
Helia Namazi, Elham Mohit, Iman Namazi, Sarah Rajabi, Azam Samadian, Ensiyeh Hajizadeh-Saffar, Nasser Aghdami, Hossein Baharvand
Exosomes are required for the regenerative effects of human cardiosphere-derived cells (CDCs). Studies show that they mimic the cardioprotective benefits of CDCs in rodents and porcine myocardial infarction (MI) models. Hypoxic preconditioning of stem cells increases the cardioprotective effects of exosomes in MI models by enhancing angiogenesis. Several exosomal microRNAs (miRNAs) up-regulate in response to hypoxia and play a role in cardioprotective and pro-angiogenic effects. In this study, we have demonstrated that human CDCs secreted exosomes under hypoxic conditions (1% O2 for 2 days) enhanced tube formation by human umbilical vein endothelial cells (HUVECs) at a concentration of 25 μg/ml...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29237495/bone-marrow-cd34-cell-subset-under-induction-of-moderate-stiffness-of-extracellular-matrix-after-myocardial-infarction-facilitated-endothelial-lineage-commitment-in-vitro
#12
Shuning Zhang, Xin Ma, Junjie Guo, Kang Yao, Cong Wang, Zhen Dong, Hong Zhu, Fan Fan, Zheyong Huang, Xiangdong Yang, Juying Qian, Yunzeng Zou, Aijun Sun, Junbo Ge
BACKGROUND: The stiffness of the myocardial extracellular matrix (ECM) and the transplanted cell type are vitally important in promoting angiogenesis. However, the combined effect of the two factors remains uncertain. The purpose of this study is to investigate in vitro the combined effect of myocardial ECM stiffness postinfarction with a bone marrow-derived cell subset expressing or not expressing CD34 on endothelial lineage commitment. METHODS: Myocardial stiffness of the infarct zone was determined in mice at 1 h, 24 h, 7 days, 14 days, and 28 days after coronary artery ligation...
December 13, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29223704/decellularized-heart-ecm-hydrogel-using-supercritical-carbon-dioxide-for-improved-angiogenesis
#13
Yoojin Seo, Youngmee Jung, Soo Hyun Kim
Initial angiogenesis within the first 3 days is critical for healing ischemic diseases such as myocardial infarction. Recently, decellularized extracellular matrix (dECM) has been reported to provide tissue-derived ECM components and can be used as a scaffold for cell delivery for angiogenesis in tissue engineering. Decellularization by various detergents such as sodium dodecyl sulfate (SDS) and triton X-100 can remove the cell nuclei in tissue organs. However, this leads to ECM structure denaturation, decreased presence of various ECM proteins and cytokines, and loss of mechanical properties...
December 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29215316/endothelial-progenitor-cells-for-cellular-angiogenesis-and-repair-lessons-learned-from-experimental-animal-models
#14
Khawaja Husnain Haider, Salim Aziz, Mateq Ali Al-Reshidi
Stem/progenitor cell-based therapy has been extensively studied for angiomyogenic repair of the ischemic heart by regeneration of the damaged myocytes and neovascularization of the ischemic tissue through biological bypassing. Given their inherent ability to assume functionally competent endothelial phenotype and release of broad array of proangiogenic cytokines, endothelial progenitor cells (EPCs)-based therapy is deemed as most appropriate for vaculogenesis in the ischemic heart. Emulating the natural repair process that encompasses mobilization and homing-in of the bone marrow and peripheral blood EPCs, their reparability has been extensively studied in the animal models of myocardial ischemia with encouraging results...
December 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29209618/platelet-derived-microvesicles-in-cardiovascular-diseases
#15
REVIEW
Maria T K Zaldivia, James D McFadyen, Bock Lim, Xiaowei Wang, Karlheinz Peter
Microvesicles (MVs) circulating in the blood are small vesicles (100-1,000 nm in diameter) derived from membrane blebs of cells such as activated platelets, endothelial cells, and leukocytes. A growing body of evidence now supports the concept that platelet-derived microvesicles (PMVs), the most abundant MVs in the circulation, are important regulators of hemostasis, inflammation, and angiogenesis. Compared with healthy individuals, a large increase of circulating PMVs has been observed, particularly in patients with cardiovascular diseases...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29177255/cell-and-gene-therapy-with-reporter-gene-imaging-in-myocardial-ischemia
#16
Chunxia Qin, Xiaotian Xia, Zhijun Pei, Yongxue Zhang, Xiaoli Lan
OBJECTIVE: Reporter gene/probe systems have proved to be reliable for monitoring gene/cell therapy. We sought to evaluate whether a reporter gene/probe system, namely the human estrogen receptor ligand binding domain (hERL)/16α-18F fluoro-17β-estradiol (18F-FES), could be used for monitoring vascular endothelial growth factor (VEGF) gene expression and response to bone marrow mesenchymal stem cell (MSCs) therapy in ischemic heart disease. ANIMALS AND METHODS: Reporter gene hERL and therapeutic gene VEGF165 were linked through internal ribosome entry site (IRES), and then the recombinant adenovirus vector Adenovirus 5-hERL-IRES-VEGF (Ad5-EIV) was constructed and transfected into MSCs, and named Ad5-EIV-MSCs...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29158084/distinct-expression-patterns-of-flk1-and-flt1-in-the-coronary-vascular-system-during-development-and-after-myocardial-infarction
#17
Shota Kurotsu, Rina Osakabe, Mari Isomi, Fumiya Tamura, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Hidenori Tani, Kaori Nara, Yoshiaki Kubota, Masatsugu Ema, Keiichi Fukuda, Takeshi Suzuki, Masaki Ieda
The coronary vascular system is critical for myocardial growth and cardiomyocyte survival. However, the molecular mechanism regulating coronary angiogenesis remains elusive. Vascular endothelial growth factor (VEGF) regulates angiogenesis by binding to the specific receptors Flk1 and Flt1, which results in different functions. Despite the importance of Flk1 and Flt1, their expression in the coronary vasculature remains largely unknown due to the lack of appropriate antibodies for immunostaining. Here, we analyzed multiple reporter mice including Flk1-GFP BAC transgenic (Tg), Flk1-LacZ knock-in, Flt1-DsRed BAC Tg, and Flk1-GFP/Flt1-DsRed double Tg animals to determine expression patterns in mouse hearts during cardiac growth and after myocardial infarction (MI)...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29096705/a-brief-review-the-therapeutic-potential-of-bone-marrow-mesenchymal-stem-cells-in-myocardial-infarction
#18
REVIEW
Chi Miao, Mingming Lei, Weina Hu, Shuo Han, Qi Wang
Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as ideal seed cells in cardiovascular disease therapy. In this review, we examine recent literature concerning the application of BMSCs for the treatment of MI and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells...
November 2, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29079346/axitinib-attenuates-intraplaque-angiogenesis-haemorrhages-and-plaque-destabilization-in-mice
#19
Bieke Van der Veken, Guido R Y De Meyer, Wim Martinet
AIM: An increased density of intraplaque (IP) microvessels in ruptured versus nonruptured human plaques suggests that IP neovascularization has a major causative effect on plaque development and instability. Possibly, vascular endothelial growth factor (VEGF) or other angiogenic factors mediate IP microvessel growth and plaque destabilization. Because apolipoprotein deficient mice with a heterozygous mutation (C1039G+/-) in the fibrillin-1 gene (ApoE-/-Fbn1C1039G+/-) manifest substantial IP neovascularization, they represent a unique tool to further investigate angiogenesis and its role in atherosclerosis...
October 31, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29057537/cpg-oligodeoxynucleotide-preconditioning-improves-cardiac-function-after-myocardial-infarction-via-modulation-of-energy-metabolism-and-angiogenesis
#20
Deng-Cheng Zhou, Yong-Hui Su, Fu-Qing Jiang, Jing-Bo Xia, Hai-Yan Wu, Zao-Shang Chang, Wen-Tao Peng, Guo-Hua Song, Kyu-Sang Park, Soo-Ki Kim, Dong-Qing Cai, Li Zheng, Xu-Feng Qi
Unmethylated CpG oligodeoxynucleotide (CpG-ODN), a Toll-like receptor 9 (TLR9) ligand, has been shown to protect against myocardial ischemia/reperfusion injury. However, the potential effects of CpG-ODN on myocardial infarction (MI) induced by persistent ischemia remains unclear. Here, we investigated whether and how CpG-ODN preconditioning protects against MI in mice. C57BL/6 mice were treated with CpG-ODN by i.p. injection 2 hr prior to MI induction, and cardiac function, and histology were analyzed 2 weeks after MI...
October 23, 2017: Journal of Cellular Physiology
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