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myocardial endothelial cell and angiogenesis

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https://www.readbyqxmd.com/read/28808223/metastasis-associated-protein-1-deficiency-results-in-compromised-pulmonary-alveolar-capillary-angiogenesis-in-mice
#1
Jun-Hui Qin, Zhen-Yu Ke, Qiang Zhou, Li Wang, Yuan Liang, Ying-Mei Wang, Tong Yang, Xing Gao, Jing Ye, Rekesh Kumar, Rui-An Wang
BACKGROUND The aim of this study was to investigate the effects of metastasis-associated protein 1 (MTA1) deficiency during angiogenesis of pulmonary alveolar capillaries in mice and to determine the molecular mechanisms involved. MATERIAL AND METHODS The expressions of MTA1, CD34, vascular endothelial growth factor (VEGF), alpha smooth muscle actin (α-SMA), and HIF-1α were analyzed in the lungs of MTA1-knockout (KO) and wild-type mice at embryonic day 18.5 and 2 months by quantitative PCR, immunoblotting, and immunohistochemistry...
August 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28765537/prdx2-in-myocyte-hypertrophy-and-survival-is-mediated-by-tlr4-in-acute-infarcted-myocardium
#2
Xian Jin, Chengjun Chen, Dandan Li, Qian Su, Yanwen Hang, Peng Zhang, Wei Hu
Peroxiredoxin 2 (PRDX2) is an antioxidant and molecular chaperone that can be secreted from tumor cells. But the role of PRDX2 in acute myocardial infarction (AMI) is not clear. In the current study, we demonstrate the role of PRDX2 from clinical trials, H9c2 cells and in a mouse model. ELISA analysis shows that serum concentrations of VEGF and inflammatory factor IL-1β, TNF-α and IL-6 were increased in AMI patients compared to a control group. The expression of PRDX2 was also upregulated. In vivo experiments show that the expression of PRDX2 inhibits hypoxia-induced oxidative stress injury to H9c2 cells...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751164/coronary-serum-obtained-after-myocardial-infarction-induces-angiogenesis-and-microvascular-obstruction-repair-role-of-hypoxia-inducible-factor-1a
#3
César Ríos-Navarro, Luisa Hueso, Gema Miñana, Julio Núñez, Amparo Ruiz-Saurí, María Jesús Sanz, Joaquin Cànoves, Francisco J Chorro, Laura Piqueras, Vicente Bodí
INTRODUCTION AND OBJECTIVES: Microvascular obstruction (MVO) exerts deleterious effects following acute myocardial infarction (AMI). We investigated coronary angiogenesis induced by coronary serum and the role of hypoxia-inducible factor-1A (HIF-1A) in MVO repair. METHODS: Myocardial infarction was induced in swine by transitory 90-minute coronary occlusion. The pigs were divided into a control group and 4 AMI groups: no reperfusion, 1minute, 1 week and 1 month after reperfusion...
July 24, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28735866/microrna-193-5p-modulates-angiogenesis-through-igf2-in-type-2-diabetic-cardiomyopathy
#4
Fan Yi, Yuqiang Shang, Bing Li, Shilin Dai, Wei Wu, Long Cheng, Xiancan Wang
BACKGROUND: Patients with diabetic cardiomyopathy are often associated with increasing risk of heart failure. In this work, we used animal model to characterize the angiogenic effect of microRNA-193-5p, miR-193-5p in type 2 diabetic Goto-Kakizaki (GK) rats' myocardial microvascular endothelial cells, MMEC(GK). METHODS: MiR-193-5p in MMEC(GK) was compared to its expression in Wistar rat MMEC. In MMEC(GK), miR-193-5p was downregulated through viral infection. Its angiogenic effects on MMEC(GK) migration and proliferation were assessed by transwell and MTT assays, respectively...
July 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28731525/differences-in-stem-cell-processing-lead-to-distinct-secretomes-secretion-implications-for-differential-results-of-previous-clinical-trials-of-stem-cell-therapy-for-myocardial-infarction
#5
Bernhard Wernly, Inês Gonçalves, Attila Kiss, Vera Paar, Tobias Mösenlechner, Michael Leisch, David Santer, Lucas Motloch, Klaus Ulrich Klein, Eva Verena Tretter, Daniel Kretzschmar, Bruno Podesser, Christian Jung, Uta C Hoppe, Michael Lichtenauer
INTRODUCTION: Stem cell therapy for acute myocardial infarction (AMI) seemed to be a promising therapy, however large clinical trials brought differential outcome. It has been shown that paracrine effects of secretomes of stem cells rather than cell therapy might play a fundamental role. The present study sought to compare cell processing protocols of clinical trials and investigated effects of differential cell culture conditions on chemokine secretion and functional effects. METHODS: Different secretomes were compared regarding IL-8, VEGF, MCP-1 and TNF-alpha secretion...
July 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28724653/haplodeficiency-of-ataxia-telangiectasia-mutated-accelerates-heart-failure-after-myocardial-infarction
#6
Lixin Jia, Wenmei Zhang, Youcai Ma, Boya Chen, Yan Liu, Chunmei Piao, Yuan Wang, Min Yang, Tingting Liu, Junmeng Zhang, Taotao Li, Shaoping Nie, Jie Du
BACKGROUND: Cell senescence is involved in the process of organ damage and repair; however, the underlying molecular mechanism needs to be further explored. METHODS AND RESULTS: Senescence-related genes (ie, p21, p53, and ataxia telangiectasia mutated [ATM]) were shown to be elevated after myocardial infarction (MI) in both mouse and human hearts. Ten- to 12-week-old male wild-type littermates (ATM(+/+)) and ATM heterozygous mice (ATM(+/-)) were subjected to MI...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28722488/berberine-promotes-ischemia-induced-angiogenesis-in-mice-heart-via-upregulation-of-microrna-29b
#7
Mo-Li Zhu, Ya-Ling Yin, Song Ping, Hai-Ya Yu, Guang-Rui Wan, Xu Jian, Peng Li
BACKGROUND: Berberine has several preventive effects on cardiovascular diseases. Increased expression of miR-29b has been reported to attenuate cardiac remodeling after myocardial infarction (MI). We hypothesized that berberine via an miR-29b-dependent mechanism promotes angiogenesis and improves heart functions in mice after MI. METHODS: The MI model was established in mice by ligation of left anterior descending coronary artery. The expression of miR-29b was examined by RT-qPCR...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28683969/impact-of-oxidative-stress-on-the-heart%C3%A2-and-vasculature-part-2-of-a-3-part-series
#8
REVIEW
Thomas Münzel, Giovanni G Camici, Christoph Maack, Nicole R Bonetti, Valentin Fuster, Jason C Kovacic
Vascular disease and heart failure impart an enormous burden in terms of global morbidity and mortality. Although there are many different causes of cardiac and vascular disease, most causes share an important pathological mechanism: oxidative stress. In the failing heart, oxidative stress occurs in the myocardium and correlates with left ventricular dysfunction. Reactive oxygen species (ROS) negatively affect myocardial calcium handling, cause arrhythmia, and contribute to cardiac remodeling by inducing hypertrophic signaling, apoptosis, and necrosis...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28678145/novel-molecular-targets-for-coronary-angiogenesis-and-ischemic-heart-disease
#9
Brittany A Potz, Anshul B Parulkar, Ruhul M Abid, Neel R Sodha, Frank W Sellke
Coronary artery disease (CAD) is the number one cause of death among men and women in the USA. Genetic predisposition and environmental factors lead to the development of atherosclerotic plaques in the vessel walls of the coronary arteries, resulting in decreased myocardial perfusion. Treatment includes a combination of revascularization procedures and medical therapy. Because of the high surgical risk of many of the patients undergoing revascularization procedures, medical therapies to reduce ischemic disease are an area of active research...
July 3, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28676523/macrophage-11%C3%AE-hsd1-deficiency-promotes-inflammatory-angiogenesis
#10
Zhenguang Zhang, Agnes E Coutinho, Janet Tak Yun Man, Tiina M J Kipari, Patrick Hadoke, Donald M Salter, Jonathan R Seckl, Karen Chapman
11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) predominantly converts inert glucocorticoids into active forms, thereby contributing to intracellular glucocorticoid levels. 11β-HSD1 is dynamically regulated during inflammation, including in macrophages where it regulates phagocytic capacity. The resolution of inflammation in some disease models including inflammatory arthritis, is impaired by 11β-HSD1 deficiency or inhibition. However, 11β-HSD1 deficiency/inhibition also promotes angiogenesis, which is beneficial in mouse models of surgical wound healing, myocardial infarction or obesity...
July 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28674292/diverse-functions-of-a-disintegrin-and-metalloproteinase-with-thrombospondin-motif-1
#11
Satoshi Hirohata, Junko Inagaki, Takashi Ohtsuki
 A disintegrin and metalloproteinase with thrombospondin motif-1 (ADAMTS1) was initially cloned from a colon cachexia cell line. In the last 20 years, novel matrix metalloproteinase (MMP) genes were found, and in addition to their original members (MMPs and membrane-type MMPs), the current MMP family contains a disintegrin and metalloproteinases (ADAMs) and ADAMTS. ADAM and ADAMTS play essential roles in organogenesis as well as various diseases including osteoarthritis. ADAMTS has 19 members and can be divided into several groups according to their substrates...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28673775/intramyocardial-bone-marrow-mononuclear-cells-versus-bone-marrow-derived-and-adipose-mesenchymal-cells-in-a-rat-model-of-dilated-cardiomyopathy
#12
M Dolores Carmona, Sagrario Cañadillas, Miguel Romero, Alfonso Blanco, Sonia Nogueras, Concha Herrera
BACKGROUND: Effects of cell therapy on dilated cardiomyopathy (DCM) have been investigated in pre-clinical models using distinct cellular types in each study. A single study that compares the effectiveness of different cells is lacking. METHODS: We have compared the effects of intramyocardial injection (IMI) of bone marrow (BM)-derived mononuclear cells (MNCs), BM and adipose tissue (AT) mesenchymal stromal cells (BM-MSCs and AT-MSCs) on heart function, histological changes and myocardial ultrastructure in a rat model of DCM...
June 30, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28646793/shexiang-baoxin-pills-promotes-angiogenesis-in-myocardial-infarction-rats-via-up-regulation-of-20-hete-mediated-endothelial-progenitor-cells-mobilization
#13
Feifei Huang, Yang Liu, Xia Yang, Di Che, Kaifeng Qiu, Bruce D Hammock, Jingfeng Wang, Mong-Heng Wang, Jie Chen, Hui Huang
BACKGROUND AND AIMS: Therapeutic angiogenesis is a pivotal strategy for ischemic heart disease. The aim of the present study was to determine the effect and molecular mechanism of Shexiang Baoxin pills, a widely-used traditional Chinese medicine for ischemic heart disease, on angiogenesis in a rat model of myocardial infarction (MI). METHODS: We used the occlusion of left anterior descending coronary artery of Sprague-Dawley rats as a model of MI. The MI rats were treated with distilled water, Shexiang Baoxin pills, or Shexiang Baoxin pills + HET0016 (a selective blocker of the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) at 10 mg/kg/day), respectively...
June 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28625239/-effects-of-human-umbilical-cord-mesenchymal-stem-cells-on-vascular-endothelial-growth-factor-and-il-6-expression-in-tissue-of-ami-rats
#14
Haihuan Xu, Huajiang Dong, Mingliang Zhao
OBJECTIVE: To investigate the effects of human umbilical cord mesenchymal stem cells (UC-MSCs) on vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) expression in acute myocardium infarction (AMI) rats. METHODS: The human UC-MSCs were cultured to the 4th generation for experiment. Sixty male Sprague-Dawley (SD) rats were randomly divided into sham group, AMI model group and UC-MSCs group, with 20 in each group. AMI animal model was produced by ligation of anterior descending coronary artery; in the sham group, the threading vein was gone below without ligation...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28614788/apelin-modulates-pathological-remodeling-of-lymphatic-endothelium-after-myocardial-infarction
#15
Florence Tatin, Edith Renaud-Gabardos, Anne-Claire Godet, Fransky Hantelys, Francoise Pujol, Florent Morfoisse, Denis Calise, Fanny Viars, Philippe Valet, Bernard Masri, Anne-Catherine Prats, Barbara Garmy-Susini
Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the onset of cardiovascular diseases such as myocardial infarction. Apelin is a bioactive peptide that plays a central role in angiogenesis and cardiac contractility. Despite an established role of apelin in lymphangiogenesis, little is known about its function in the cardiac lymphatic endothelium...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28609713/nicorandil-modulated-macrophages-activation-and-polarization-via-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Fengyun Zhang, Yongli Xuan, Jinjin Cui, Xinxin Liu, Zhiying Shao, Bo Yu
Nicorandil, a drug with both nitrate-like and ATP-sensitive potassium (KATP) channel-activating properties, has been well demonstrated in various aspects of myocardial infarction (MI), especially in inhibiting cell apoptosis and increasing coronary flow. However, the role of nicorandil in regulating inflammation and angiogenesis following myocardial infarction is still unrevealed. In the present study, we explored the effect of nicorandil on macrophage phenotype transition and inflammation regulation and the potential underlying mechanisms...
June 10, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28576854/mdivi-1-induced-acute-changes-in-the-angiogenic-profile-after-ischemia-reperfusion-injury-in-female-mice
#17
Sudhakar Veeranki, Suresh C Tyagi
The aim of this study is to determine the effects of mitochondrial division inhibitor 1 (Mdivi-1), the mitochondrial fission inhibitor, on the angiogenic profiles after the ischemia reperfusion injury (IR injury) in female mice. Female mice were treated with Mdivi-1 inhibitor, 2 days prior, on the day of IR injury and 2 days after IR injury, for a period of 5 days. Both control and treatment groups underwent 30 min of ischemia and 72 h of reperfusion. On the day 3, mice were sacrificed and the ischemic and nonischemic portions of heart tissue were collected...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28570978/inhibition-of-long-noncoding-rna-igf2as-promotes-angiogenesis-in-type-2-diabetes
#18
Zhuo Zhao, Bin Liu, Bo Li, Chunli Song, Hongying Diao, Ziyuan Guo, Zhibo Li, Jichang Zhang
BACKGROUND: In this study, the angiogenic effect of long noncoding RNA (lncRNA), insulin growth factor 2 antisense (IGF2AS) in type 2 diabetes was evaluated. METHODS: Between Wistar rat and Goto-Kakizaki (GK) rat, a genetic model of type 2 diabetes, mRNA expressions of IGF2AS and IGF2 in myocardial microvascular endothelial (mMVE) cells were compared by qRT-PCR. In GK mMVE cells, IGF2AS was inhibited by siRNA. Its effects on cell proliferation and invasion were evaluated by MTT and wound-healing assays...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28565841/ultrasound-combined-with-targeted-cationic-microbubble-mediated-angiogenesis-gene-transfection-improves-ischemic-heart-function
#19
Qing Zhou, Qing Deng, Bo Hu, Yi-Jia Wang, Jin-Ling Chen, Jing-Jing Cui, Sheng Cao, Hong-Ning Song
The present study aimed to construct targeted cationic microbubbles (TCMBs) by synthesizing cationic microbubbles conjugated to an intercellular adhesion molecule-1 (ICAM-1) antibody, and then to use the TCMBs to deliver the angiopoietin-1 (Ang-1) gene into infarcted heart tissue using ultrasound-mediated microbubble destruction. It was hypothesized that the TCMBs would accumulate in higher numbers than non-targeted cationic microbubbles (CMBs) in the infarcted heart, and would therefore increase the efficiency of targeted Ang-1 gene transfection and promote angiogenesis...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28550172/myocardial-overexpression-of-timp3-following-myocardial-infarction-exerts-beneficial-effects-through-promoting-angiogenesis-and-suppressing-early-proteolysis
#20
Abhijit Takawale, Pu Zhang, Abul Azad, Wang Wang, Xiuhua Wang, Allan G Murray, Zamaneh Kassiri
Myocardial infarction (MI) results in loss of cardiomyocytes, adverse extracellular matrix (ECM) and structural remodeling, left ventricular (LV) dilation and dysfunction. Tissue inhibitor of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), the main regulators of ECM turnover. TIMPs also have MMP-independent functions. TIMP3 levels are reduced in the heart within 24 hours of MI in mice. We investigated if overexpression of TIMP3 post-MI limits adverse remodeling, LV dilation and dysfunction...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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