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Eun Kyung Choi, Shiback Lee, Won Jae Kim, Sang-Jin Park
BACKGROUND: Emergence delirium is a common complication of sevoflurane anesthesia in children. AIMS: We examined the effects of maintaining remifentanil infusion during the recovery period on the incidence of emergence delirium in preschool-age children undergoing strabismus surgery under sevoflurane anesthesia. METHODS: Eighty children (aged 3-7 years) were randomly assigned to either the control group (group C; intraoperative remifentanil infusion) or the intervention group (group R; intraoperative remifentanil infusion followed by remifentanil maintenance during the recovery phase)...
July 13, 2018: Paediatric Anaesthesia
Aya Yamauchi, Takashi Okada, Masahiko Ando, Mako Morikawa, Yukako Nakamura, Chika Kubota, Masako Ohara, Satomi Murase, Setsuko Goto, Atsuko Kanai, Norio Ozaki
Background: The Highs scale has been developed to evaluate hypomanic symptoms in the first postpartum week. However, it has not been elucidated whether this scale is also applicable to pregnant women. To address this issue, we confirmed the factor structure, reliability, and validity of the Japanese version of the Highs scale for pregnant and postpartum women. Methods: 418 women provided effective responses to both the Highs scale and the Edinburgh Postnatal Depression Scale (EPDS) during early pregnancy (before week 25), late pregnancy (around week 36), at 5 days and at 1 month after delivery...
2018: Frontiers in Psychiatry
B McHale, C D Badenhorst, C Low, D Blundell
OBJECTIVE: A double-blinded, randomised, placebo-controlled trial was conducted to determine whether routine pre-operative analgesia is beneficial in reducing post-operative ear pain following bilateral myringotomy and tube placement. METHODS: Forty-five children (aged 3-15 years) were randomised to receive either pre-operative analgesics (paracetamol and ibuprofen) (n = 21) or placebo (n = 24). All children underwent sevoflurane gas induction with intranasal fentanyl (2 mcg/kg) to reduce the incidence of emergence agitation...
July 12, 2018: Journal of Laryngology and Otology
Raffaele Scala, Lara Pisani
Noninvasive positive-pressure ventilation (NPPV) to treat acute respiratory failure has expanded tremendously over the world in terms of the spectrum of diseases that can be successfully managed, the locations of its application and achievable goals.The turning point for the successful expansion of NPPV is its ability to achieve the same physiological effects as invasive mechanical ventilation with the avoidance of the life-threatening risks correlated with the use of an artificial airway.Cardiorespiratory arrest, extreme psychomotor agitation, severe haemodynamic instability, nonhypercapnic coma and multiple organ failure are absolute contraindications for NPPV...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
Agnieszka Janeczek, Marcin Zawadzki, Pawel Szpot, Artur Niedzwiedz
BACKGROUND: Cannabis from hemp (Cannabis sativa and C. indica) is one of the most common illegal drugs used by drug abusers. Indian cannabis contains around 70 alkaloids, and delta-9-tetrahydrocannabinol (delta-9-THC) is the most psychoactive substance. Animal intoxications occur rarely and are mostly accidental. According to the US Animal Poison Control Center, cannabis intoxication mostly affects dogs (96%). The most common cause of such intoxication is unintentional ingestion of a cannabis product, but it may also occur after the exposure to marijuana smoke...
July 11, 2018: Acta Veterinaria Scandinavica
Mary P Kovacevic, Paul M Szumita, Kevin M Dube, Jeremy R DeGrado
BACKGROUND: The 2013 Society of Critical Care Medicine guidelines for the management of pain, agitation, and delirium in adult intensive care unit (ICU) patients recommend intravenous opioids as first-line therapy to treat nonneuropathic pain. There is a paucity of literature describing possible benefits of utilizing specific opioids over others in ICU patients. OBJECTIVE: The objective was to identify rationales for the transition from continuous infusion fentanyl to continuous infusion hydromorphone in critically ill patients...
January 1, 2018: Journal of Pharmacy Practice
X J Xue, R L He, W X Li, J W Xin, Q Y Ye, X C Chen, X D Pan
Objective: To assess the safety of olanzapine, risperidone and quetiapine drugs in dementia patients with behavioral and psychological symptoms. Methods: The EMBASE, Cochrane Controlled Trials Register and the Cochrane Database of Systematic Reviews, Medline, CNKI, Wang Fang were systematically searched for eligible randomized controlled trials of olanzapine, risperidone and quetiapine drugs therapy in patients with psychotic symptoms of dementia before February 2016. Two reviewers independently assessed the quality of the trials and extracted information...
July 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Manasa Mithun, Vani Rajashekaraiah
: Platelets are stored at 22-24°C for 5 days, with gentle agitation. Platelet storage lesion decreases efficacy and safety of stored platelets. L-Carnitine is a nonessential amino acid. Its interference with arachidonic acid metabolism affects platelet functions and oxidative stress. Hence, our study focuses on the use of L-carnitine in storage solution and investigates its influence on platelet functions and oxidative stress. Platelets isolated from 4-month-old male Wistar rats were stored with and without L-carnitine (10, 50 and 100 mmol/l) at 22°C for 12 days...
July 10, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Andreas Hirsch, Tobial Luchs, Marco Sarcletti, Marcus Halik, Luis Portilla, Sjoerd Harder, Christian Fischer, Lukas Zeininger
We report on the development of a supramolecular nanocarrier concept that allows for the encapsulation and separation of small apolar molecules from water. The nanocarriers consist of shell-by-shell coated nanoparticles such as TiO2 and ferromagnetic Fe3O4. The first ligand shell is provided by covalently bound hexadecyl phosphonic acid (PAC16) and the second shell by non-covalently assembled amphiphiles rendering the hybrid architecture soluble in water. Agitation of these constructs with water containing the hydrocarbons G1-G4, the fluorescent marker G5, the polychlorinated biphenyl PCB 77 or crude oil leads to a very efficient uptake (up to 411 %) of the apolar contaminant...
July 10, 2018: Chemistry: a European Journal
N Warren, D Siskind, C O'Gorman
OBJECTIVE: To review the psychiatric symptoms of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, in an attempt to differentiate the presentation from a primary psychiatric disorder. METHOD: A systematic literature review of PubMed and EMBASE of all published cases of anti-NMDA receptor encephalitis was performed from inception to January 2018. RESULTS: There were 706 cases of anti-NMDA receptor encephalitis identified. Cases were typically young (mean age 22...
July 10, 2018: Acta Psychiatrica Scandinavica
Yong Hu, Takuro Kobayashi, Guangyin Zhen, Chen Shi, Kai-Qin Xu
To investigate the influence of lipid concentration (of total solids, w/w) on anaerobic treatment of food waste under thermophilic condition, a siphon-driven self-agitated anaerobic reactor was operated for 220 days. The average lipid concentration was changed from 12.8% to 59.3% (w/w) step by step. The gas production rate increased from 1.97 to 2.31 L/L/d with lipid concentration increased from 12.8% to 19.7% (w/w), whereas decreased sharply to 0.78 L/L/d when the concentration further increased to 59...
September 2018: Biotechnology Reports
Ines Basso, Laura Simionato, Valerio Dimonte, Serena Scaglione, Sara Campagna
. The Emergency Department visits of Nursing Home residents: descriptive study in a Nursing Home. INTRODUCTION: Many Emergency Departments (ED) transfers of Nursing Home (NH) residents are potentially avoidable or even inappropriate since problems could be prevented or managed in the NH. AIM: To describe characteristics and outcomes of NH residents transferred to ED for respiratory, cardiovascular and neurological problems and symptoms of infection. METHODS: A retrospective descriptive study using clinical records data from 2013-2016 of a NH was conducted...
April 2018: Assistenza Infermieristica e Ricerca: AIR
Ermellina Zanetti, Michele Zani, Moira Poli, Christian Mottin, Mario Marin
. The use of physical restraints in older adults receiving home care: a cross-sectional study in a district of northen Italy. INTRODUCTION: Research on restraint use in home care residents cared by non professional caregivers is scarce. AIM: To evaluate the prevalence of physical restraints among the elderly assisted by the home care services in the District 1 of Bassano del Grappa ULSS7 Pedemontana (Veneto Region, Italy). METHOD: This observational cross-sectional survey was conducted by the 28 home care nurses on all subjects receiving at least one home care service by a nurse during the survey period (13 March-15 April 2017)...
April 2018: Assistenza Infermieristica e Ricerca: AIR
Slavica Vučinić, Vesna Kilibarda, Snežana Đorđević, Dragana Đorđević, Nataša Perković-Vukčević, Gordana Vuković-Ercegović, Biljana Antonijević, Marijana Ćurčić, Evica Antonijević, Gordana Brajković
A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC...
June 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
Amelia M Kasper, Alison D Ridpath, Roy R Gerona, Robert Cox, Robert Galli, Patrick B Kyle, Christina Parker, Justin K Arnold, Kevin Chatham-Stephens, Melissa A Morrison, Olaniyi Olayinka, Nykiconia Preacely, Stephanie M Kieszak, Colleen Martin, Joshua G Schier, Amy Wolkin, Paul Byers, Thomas Dobbs
STUDY OBJECTIVES: In April 2015, a multistate outbreak of illness linked to synthetic cannabinoid (SC) use was unprecedented in magnitude and severity. We identified Mississippi cases in near-real time, collected information on cases to characterize the outbreak, and identified the causative SC. METHODS: A case was defined as any patient of a Mississippi healthcare facility who was suspected of SC use and presenting with ≥2 of the following symptoms: sweating, severe agitation, or psychosis during April 2-May 3, 2015...
July 10, 2018: Clinical Toxicology
Huei-Ling Huang, Yea-Ing L Shyu, Wen-Chuin Hsu
Background/aims: Limited research has been conducted on agitated behavior in Taiwan and dementia among community-dwelling elderly. Therefore, this study focused on community elderly with dementia and a factor analysis of an inventory of their agitated behaviors was conducted. Patients and methods: Participants (N=221) completed the Chinese Cohen-Mansfield Agitation Inventory, community form. Item analysis and exploratory factor analysis assessed reliability, validity, and the underlying factor structure...
2018: Clinical Interventions in Aging
Ryosuke Tsuruta, Motoki Fujita
Guideline-based management approaches for pain, agitation, and delirium (PAD) in critically ill adult patients are widely believed to result in good outcomes. However, there are some differences in the recommendations and evidence levels among the management guidelines established for PAD. To identify and compare the current management guidelines, we used the PubMed database. The PAD guidelines and Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva (FEPIMCTI) guidelines were identified from our search...
July 2018: Acute Medicine & Surgery
M K Mosharaf, M Z H Tanvir, M M Haque, M A Haque, M A A Khan, A H Molla, Mohammad Z Alam, M S Islam, M R Talukder
Bacterial biofilm plays a pivotal role in bioremediation of heavy metals from wastewaters. In this study, we isolated and identified different biofilm producing bacteria from wastewaters. We also characterized the biofilm matrix [i.e., extracellular polymeric substances (EPS)] produced by different bacteria. Out of 40 isolates from different wastewaters, only 11 (27.5%) isolates (static condition at 28°C) and 9 (22.5%) isolates (agitate and static conditions at 28 and 37°C) produced air-liquid (AL) and solid-air-liquid (SAL) biofilms, respectively, only on salt-optimized broth plus 2% glycerol (SOBG) but not in other media tested...
2018: Frontiers in Microbiology
Anagha Bhakay, Mahbubur Rahman, Rajesh N Dave, Ecevit Bilgili
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs. Drug nanoparticles are prepared by top-down, bottom-up, or combinative approaches in the form of nanosuspensions, which are subsequently dried to prepare drug-laden nanocomposites. In this comprehensive review paper, the term “nanocomposites” is used in a broad context to cover drug nanoparticle-laden intermediate products in the form of powders, cakes, and extrudates, which can be incorporated into final oral solid dosages via standard pharmaceutical unit operations, as well as drug nanoparticle-laden strip films...
July 8, 2018: Pharmaceutics
Adam Kadri, Penny Rapaport, Gill Livingston, Claudia Cooper, Sarah Robertson, Paul Higgs
Personhood discourses in dementia care have gained prominence and current care home standards mandate that care should be "person-centred". However, it is unclear how the personhood of staff is construed within the care relationship. This paper aims to explore how the personhood of paid carers of people with dementia can be understood by focussing on the views and experiences of care home staff. We undertook a secondary qualitative analysis of interviews with 25 paid care staff in England, conducted as part of the MARQUE (Managing Agitation and Raising QUality of lifE) study...
2018: PloS One
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