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https://www.readbyqxmd.com/read/28530571/novel-insights-into-ascorbate-retention-and-degradation-during-the-washing-and-post-harvest-storage-of-spinach-and-other-salad-leaves
#1
Rebecca A Dewhirst, Graham J J Clarkson, Steve D Rothwell, Stephen C Fry
Post-harvest treatments of pre-packaged salad leaves potentially cause l-ascorbate loss, but the mechanisms of ascorbate degradation remain incompletely understood, especially in planta. We explored the extent and pathways of ascorbate loss in variously washed and stored salad leaves. Ascorbate was assayed by 2,6-dichlorophenolindophenol titration, and pathways were monitored by (14)C-radiolabelling followed by high-voltage electrophoresis. All leaves tested showed ascorbate loss during storage: lettuce showed the greatest percentage loss, wild rocket the least...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28529602/super-aqueous-solubility-of-albendazole-in-%C3%AE-cyclodextrin-for-parenteral-application-in-cancer-therapy
#2
Krishna Pillai, Javed Akhter, David Lawson Morris
Poor aqueous solubility of anticancer drug, albendazole (ABZ), prevents parenteral application. Here, we demonstrate how to increase the aqueous solubility of ABZ to 6- 8 mg/ml using sulfobutylether - β-cyclodextrin (SBE-β-CD) or Hydroxypropyl- β-cyclodextrin (HP- β-CD) by manipulation of complexation parameters such as the physical state of ABZ (ionized in acetic acid), the concentration of ionised ABZ, agitation time and temperature. Solubility was first examined with suspension of excess ABZ powder in cyclodextrin (CD) solutions at pH (2...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28528382/optimal-production-of-a-rhodococcus-erythropolis-atcc-4277-biocatalyst-for-biodesulfurization-and-biodenitrogenation-applications
#3
Diego Todescato, Danielle Maass, Diego Alex Mayer, J Vladimir Oliveira, Débora de Oliveira, Selene M A Guelli Ulson de Souza, Antônio Augusto Ulson de Souza
Rhodococcus sp. has a broad catabolic diversity and unique enzymatic capabilities, and it is able to adapt under extreme conditions. Thereby, the production of this remarkable bacterium has a great biotechnological and industrial importance. In this sense, we sought to improve the R. erythropolis ATCC 4277 growth through a central composite design, by varying the components of nutrient medium (glucose, malt extract, yeast extract, CaCO3), temperature, and agitation. It was found that the concentrations of glucose and malt extract are not statistically significant, being reduced of 4...
May 20, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28528211/intravenous-levetiracetam-vs-phenytoin-for-status-epilepticus-and-cluster-seizures-a-prospective-randomized-study
#4
Arunodaya R Gujjar, Ramachandiran Nandhagopal, Poovathoor C Jacob, Abdulhakeem Al-Hashim, Khalfan Al-Amrani, Shyam S Ganguly, Abdullah Al-Asmi
PURPOSE: Status Epilepticus (SE) is a common medical emergency carrying a high morbidity and mortality. Levetiracetam (LEV) is a novel anticonvulsant effective against varied seizures. Few prospective studies have addressed its use in SE. We aimed to examine the efficacy of intravenous LEV in controlling SE and cluster attacks of seizures (CS), in comparison with IV phenytoin (DPH), using a prospective, randomized study design. METHOD: Adult patients with SE or CS, following an initial dose of IV benzodiazepine to control ongoing seizure, were randomized to receive either medication...
May 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28523956/pathogen-reduction-technologies-the-pros-and-cons-for-platelet-transfusion
#5
Audrey Magron, Jonathan Laugier, Patrick Provost, Eric Boilard
The transfusion of platelets is essential for diverse pathological conditions associated with thrombocytopenia or platelet disorders. To maintain optimal platelet quality and functions, platelets are stored as platelet concentrates (PCs) at room temperature under continuous agitation-conditions that are permissive for microbial proliferation. In order to reduce these contaminants, pathogen reduction technologies (PRTs) were developed by the pharmaceutical industry and subsequently implemented by blood banks...
May 19, 2017: Platelets
https://www.readbyqxmd.com/read/28523268/the-sedative-effect-of-propranolol-on-critically-ill-patients-a-case-series
#6
Junji Shiotsuka, Andrew Steel, James Downar
INTRODUCTION: Recent studies have examined the effectiveness of alpha-2 adrenergic agonists for controlling delirium and agitation. Propranolol, a non-selective beta-adrenergic antagonist with good penetration of the blood-brain barrier, has not been investigated for this purpose. MATERIALS AND METHODS: We retrospectively reviewed the medical records of all patients who were prescribed propranolol in our Medical Surgical ICU from January 1, 2010, to December 31, 2013...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28522914/one-year-experience-with-computer-assisted-propofol-sedation-for-colonoscopy
#7
Otto S Lin, Danielle La Selva, Richard A Kozarek, Deborah Tombs, Wade Weigel, Ryan Beecher, Johannes Koch, Susan McCormick, Michael Chiorean, Fred Drennan, Michael Gluck, Nanda Venu, Michael Larsen, Andrew Ross
AIM: To report our one-year experience with computer assisted propofol sedation (CAPS) for colonoscopy as the first United States Medical Center to adopt CAPS technology for routine clinical use. METHODS: Between September 2014 and August 2015, 2677 patients underwent elective outpatient colonoscopy with CAPS at our center. All colonoscopies were performed by 1 of 17 gastroenterologists certified in the use of the CAPS system, with the assistance of a specially trained nurse...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28522892/enhancing-communication-in-adults-with-dementia-and-age-related-hearing-loss
#8
REVIEW
Sara K Mamo, Esther Oh, Frank R Lin
For many adults with dementia, age-related hearing loss is undiagnosed and/or untreated. Untreated hearing loss can exacerbate common dementia-related behavioral symptoms, such as depression, apathy, agitation. Despite the potential benefits to the individual and the family, pursuing and adopting hearing aids for persons with dementia presents with many challenges. As such, this group of vulnerable older adults is well suited for alternative approaches that adopt an interventional audiology framework. This article reviews alternative hearing care models that we have tested when working with older adults with cognitive impairments...
May 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/28521507/biosorption-of-chromium-vi-in-aqueous-solutions-by-chemically-modified-strychnine-tree-fruit-shell
#9
E Nakkeeran, N Selvaraju
Chromium(VI) removal from aqueous solution was performed using sulphuric and phosphoric acid activated Strychnine tree fruit shell (SSTFS and PSTFS) as biosorbents. Effect of various parameters such as adsorbent dose (0.02 - 0.1g/L), temperature (303 - 333K), agitation speed, solution pH (2-9), contact time & initial Cr (VI) concentration (50-250 mg/L) were studied for a batch adsorption system. The optimum pH range for Cr(VI) adsorption was determined as 2. Equilibrium adsorption data were analyzed with isotherm models and the Langmuir and Freundlich model got best fitted for SSTFS (R(2) value-0...
May 19, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28514726/retrospective-analysis-of-risk-factors-associated-with-kawasaki-disease-in-china
#10
Lihua Bai, Tienan Feng, Lifang Yang, Yi Zhang, Xuejuan Jiang, Jiayao Liao, Lihua Chen, Xiaoyan Feng, Yanming Rong, Yuehua Li, Zhiqiang Qin, Jing Qiao
In order to provide early intervention for coronary artery lesion (CAL) caused by Kawasaki Disease (KD), we analyzed clinical characteristics of typical and incomplete KD cases from 1998 to 2008 in Northwest and Central China. A total of 383 patients included 298 cases of typical KD and 85 cases of incomplete KD. The morbidity of incomplete KD was 28.5%, a percentage significantly lower than that of typical KD. The occurrence of bulbar conjunctiva congestion, erythra, crissum red, film-like decrustation, lip red, rhagades, raspberry tongue, bilateral toe-end decrustation, limb sclerosis, cervical lymph nodes enlargement, agitation and irritability in incomplete KD group was lower than that in the group of typical KD (p < 0...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28513876/the-inter-play-between-facilitation-and-context-in-the-promoting-action-on-research-implementation-in-health-services-framework-a-qualitative-exploratory-implementation-study-embedded-in-a-cluster-randomised-controlled-trial-to-reduce-restraint-in-nursing-homes
#11
Tone Elin Mekki, Christine Øye, Bodil Margrete Kristensen, Helen Dahl, Astrid Haaland, Kristin Aas Nordin, Marta R Strandos, Toril Marie Terum, Arnt Egil Ydstebø, Brendan Mccormack
AIM: To explore the inter-play between external facilitation and nursing home contexts relative to intervention outcomes. BACKGROUND: The Promoting Action on Research Implementation in Health Services framework is frequently used to theoretically inform implementation and research in nursing and recent reviews indicate high face validity for health services. However, the inter-play and relationship between framework sub- elements of evidence, context and facilitation and the prospective utility in non-English speaking contexts warrant further illumination...
May 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28508331/is-pesticide-sorption-by-constructed-wetland-sediments-governed-by-water-level-and-water-dynamics
#12
Céline Gaullier, Sylvie Dousset, David Billet, Nicole Baran
Constructed wetlands (CWs) are used to reduce the pesticide inputs from tile drainage or run-off to surface water. Their effectiveness appears variable and remains to be better characterized and understood. The aim of this study was to assess the influences of two hydraulic parameters (i.e., dynamics and water level) on the sorption process occurring in CWs. Then, two solid/liquid ratios were studied (1/1 and 1/5) to mimic the water level variation in the field, and two agitation speeds were used (none and gentle agitation) to simulate different water dynamics (stagnation and flow pass, respectively)...
May 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28507634/multi-system-complications-after-intravenous-cocaine-abuse
#13
Lidija Petkovska, Andon Chibishev, Aleksandra Stevcevska, Ivica Smokovski, Dusan Petkovski, Emilija Antova
BACKGROUND: Use and abuse of cocaine are associated with numerous adverse effects, independent of the route of administration. More severe conditions of poisoning, however, are observed after cocaine intravenous administration. AIM: We present a case of severe poisoning after violent intravenous injection of cocaine, but with a good outcome. CASE PRESENTATION: Cocaine was intravenously (i.v.) administered in 16-years old female patient as a homicide attempt...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28506099/propofol-based-palliative-sedation-to-treat-antipsychotic-resistant-agitated-delirium
#14
Alfredo Covarrubias-Gómez, Maria López Collada-Estrada
Delirium is a common problem in terminally ill patients that is associated with significant distress and, hence, considered a palliative care emergency. The three subtypes of delirium are hyperactive, hypoactive, and mixed, depending on the level of psychomotor activity and arousal disturbance. When agitated delirium becomes refractory in the setting of imminent dying, the agitation may be so severe that palliative sedation (PS) is required. Palliative sedation involves the administration of sedative medications with the purpose of reducing level of consciousness for patients with refractory suffering in the setting of a terminal illness...
May 16, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28505432/development-of-a-new-extraction-device-based-on-parallel-electromembrane-extraction
#15
Nicolas Drouin, Jean-François Mandscheff, Serge Rudaz, Julie Schappler
A new device for parallel-electromembrane extraction (Pa-EME) was developed to enable simultaneous and high-throughput extraction of ionic and ionizable compounds from biofluids. The new system is composed of a reusable conductive well-plate used as an acceptor compartment and a commercial filtration well-plate used as a donor com-partment. A design of experiments was implemented to optimize the main experimental parameters (agitation, voltage, and time) with standard solutions in formic acid 50 mM. The stirring rate was found the primary influent parameter...
May 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28501987/effect-of-glucose-and-olive-oil-as-potential-carbon-sources-on-production-of-phas-copolymer-and-tercopolymer-by-bacillus-cereus-fa11
#16
Farha Masood, Maria Abdul-Salam, Tariq Yasin, Abdul Hameed
In this study, the influence of different physicochemical parameters on the yield of polyhydroxyalkanoates (PHAs) produced by Bacillus cereus FA11 is investigated. The physicochemical factors include pH, temperature, time, inoculum size and its age, agitation speed and composition of the glucose rich peptone deficient (GRPD) medium. During two-stage fermentation, B. cereus FA11 produced a significantly high (p < 0.05) yield (80.59% w/w) of PHAs copolymer using GRPD medium containing glucose (15 g/L) and peptone (2 g/L) at pH 7, 30 °C and 150 rpm after 48 h of incubation...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28501162/solidification-of-floating-organic-droplet-in-dispersive-liquid-liquid-microextraction-as-a-green-analytical-tool
#17
REVIEW
Fotouh R Mansour, Neil D Danielson
Dispersive liquid-liquid microextraction (DLLME) is a special type of microextraction in which a mixture of two solvents (an extracting solvent and a disperser) is injected into the sample. The extraction solvent is then dispersed as fine droplets in the cloudy sample through manual or mechanical agitation. Hence, the sample is centrifuged to break the formed emulsion and the extracting solvent is manually separated. The organic solvents commonly used in DLLME are halogenated hydrocarbons that are highly toxic...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28501048/systematic-review-of-evidence-underpinning-non-pharmacological-therapies-in-dementia
#18
Richard Olley, Andrea Morales
Objective Dementia is one of the most common illnesses worldwide, and is one of the most important causes of disability in older people. Currently, dementia affects over 35million people around the globe. It is expected that this number will increase to 65.7million by 2030. Early detection, diagnosis and treatment to control the principal behaviour symptoms may help reduce these numbers and delay the progression to more advanced and dangerous stages of this disorder with resultant increase quality of life for those affected...
May 15, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28501003/phytochemicals-for-taming-agitated-immune-endocrine-neural-axis
#19
REVIEW
Seema Patel
Homeostasis of immune-endocrine-neural axis is paramount for human health. If this axis gets agitated due to age, genetic variations, environmental exposures or lifestyle assaults, a cascade of adverse reactions occurs in human body. Cytokines, hormones and neurotransmitters, the effector molecules of this axis behave erratically, leading to a gamut of neural, endocrine, autoimmune, and metabolic diseases. Current panel of drugs can tackle some of them but not in a sustainable, benign way as a myriad of side effects, causal of them have been documented...
May 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28500785/don-t-label-me-a-qualitative-study-of-patients-perceptions-and-experiences-of-sedation-during-behavioral-emergency-in-the-emergency-department
#20
Celene Y L Yap, Jonathan C Knott, David C M Kong, Marie Gerdtz, Kay Stewart, David McD Taylor
OBJECTIVES: Behavioral emergencies are commonly seen in emergency departments. Acutely agitated patients can be difficult to manage and sedation may be required to decrease dangerous behavior and to ensure the safety of both the patient and staff. While the experience of staff caring for this population has been reported, patients' experiences with their overall management remains unknown. We aimed to describe the perceptions and experiences of patients regarding the use of sedation during acute behavioral emergencies...
May 13, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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