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https://www.readbyqxmd.com/read/28092004/bio-based-degradation-of-emerging-endocrine-disrupting-and-dye-based-pollutants-using-cross-linked-enzyme-aggregates
#1
Muhammad Bilal, Muhammad Asgher, Hafiz M N Iqbal, Hongbo Hu, Xuehong Zhang
In this study, manganese peroxidase (MnP) from an indigenous white-rot fungus Ganoderma lucidum IBL-05 was insolubilized in the form of cross-linked enzyme aggregates (CLEAs) using various aggregating agents, i.e., acetone, ammonium sulfate, ethanol, 2-propanol, and tert-butanol, followed by glutaraldehyde (GA) cross-linking. The precipitant type, MnP, and GA concentrations affected the CLEAs activity recovery and aggregation yield. Among precipitants used, acetone appeared to be the most efficient aggregation agent, providing the highest activity recovery and aggregation yield of 31...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28090716/does-item-overlap-render-measured-relationships-between-pain-and-challenging-behaviour-trivial-results-from-a-multicentre-cross-sectional-study-in-13-german-nursing-homes
#2
Patrick Kutschar, Zsuzsa Bauer, Irmela Gnass, Jürgen Osterbrink
Several studies suggest that pain is a trigger for challenging behaviour in older adults with cognitive impairment. However, such measured relationships might be confounded due to item overlap as instruments share similar or identical items. The purpose of this study was to examine whether the frequently observed association between pain and challenging behaviour might be traced back to item overlap. This multicentre cross-sectional study was conducted in 13 nursing homes and examined pain (measure: Pain Assessment in Advanced Dementia Scale) and challenging behaviour (measure: Cohen-Mansfield Agitation Inventory) in 150 residents with severe cognitive impairment...
January 16, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28089934/evaluation-of-aggregate-and-silicone-oil-counts-in-pre-filled-siliconized-syringes-an-orthogonal-study-characterising-the-entire-subvisible-size-range
#3
Maryam Shah, Zahra Rattray, Katie Day, Shahid Uddin, Robin Curtis, Christopher F van der Walle, Alain Pluen
Characterisation of particulates in therapeutic monoclonal antibody (mAb) formulations is routinely extended to the sub-visible size-range (0.1-10μm). Additionally, with the increased use of pre-filled syringes (PFS), particle differentiation is required between proteinaceous and non-proteinaceous particles such as silicone-oil droplets. Here, three orthogonal techniques: Raster Image Correlation Spectroscopy (RICS), Resonance Mass Measurements (RMM) and Micro-Flow Imaging (MFI), were evaluated with respect to their sub-visible particle measurement and characterisation capabilities...
January 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28088096/mycelium-transformation-of-streptomyces-toxytricini-into-pellet-role-of-culture-conditions-and-kinetics
#4
Punit Kumar, Kashyap Kumar Dubey
The present study envisages the role of different carbon sources, nitrogen sources, metals, pH, inoculum volume and agitation rate in pellet formation of S. toxytricini at shake-flask level. It was found that galactose, ammonium sulphate, sodium nitrate, Cu(2+), Zn(2+), higher inoculum volume (5% v/v) and agitation rate at 300rpm caused significant reduction in pellet size (up to the range of 30μm-0.5mm) but biomass formations was also reduced subsequently. Interestingly diffused type of morphology was obtained in Fe(2+) supplemented medium with reduced biomass (1...
January 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28081525/effect-of-free-nitrous-acid-pre-treatment-on-primary-sludge-at-low-exposure-times
#5
S Zahedi, P Icaran, Z Yuan, M Pijuan
The present study was undertaken to investigate the effect of different free nitrous acid (FNA) concentrations at low pre-treatment times (PTs) (1, 2 and 5h) and without pH control with mild agitation on primary sludge (PS) biodegradability and methane production (MP). Increasing PTs resulted in an increase in the solubility of the organic matter (around 25%), but not on cell-mortality (>75% in all the cases with FNA) and neither on methane generation. FNA pre-treatment at low PTs improve MP (around 16% at PT of 1h and 650mg N-NO2(-)/L)...
January 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28079675/recent-advances-in-the-management-of-neuropsychiatric-symptoms-in-dementia
#6
Orestes V Forlenza, Júlia Cunha Loureiro, Marcos Vasconcelos Pais, Florindo Stella
PURPOSE OF REVIEW: The present article addresses intriguing questions related to the clinical intervention in distinct neuropsychiatric syndromes of patients with dementia. RECENT FINDINGS: We reviewed 154 articles published between 2015 and 2016 targeting psychopharmacological and nonpharmacological interventions, and safety-tolerability concerns. We selected 115 articles addressing the purpose of this study. Of these, 33 were chosen because they were dedicated to subtopics: agitation (42), depression (33), apathy (18), sleep disorders/anxiety (8), and psychosis (4)...
January 12, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28078651/fed-batch-enzymatic-saccharification-of-high-solids-pretreated-lignocellulose-for-obtaining-high-titers-and-high-yields-of-glucose
#7
Young Hoon Jung, Hyun Min Park, Dong Hyun Kim, Jungwoo Yang, Kyoung Heon Kim
To reduce the distillation costs of cellulosic ethanol, it is necessary to produce high sugar titers in the enzymatic saccharification step. To obtain high sugar titers, high biomass loadings of lignocellulose are necessary. In this study, to overcome the low saccharification yields and the low operability of high biomass loadings, a fed-batch saccharification process was developed using an enzyme reactor that was designed and built in-house. After optimizing the cellulase and biomass feeding profiles and the agitation speed, 132...
January 11, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28078397/optimized-synthesis-of-novel-prenyl-ferulate-performed-by-feruloyl-esterases-from-myceliophthora-thermophila-in-microemulsions
#8
Io Antonopoulou, Laura Leonov, Peter Jütten, Gabriella Cerullo, Vincenza Faraco, Adamantia Papadopoulou, Dimitris Kletsas, Marianna Ralli, Ulrika Rova, Paul Christakopoulos
Five feruloyl esterases (FAEs; EC 3.1.1.73), FaeA1, FaeA2, FaeB1, and FaeB2 from Myceliophthora thermophila C1 and MtFae1a from M. thermophila ATCC 42464, were tested for their ability to catalyze the transesterification of vinyl ferulate (VFA) with prenol in detergentless microemulsions. Reaction conditions were optimized investigating parameters such as the medium composition, the substrate concentration, the enzyme load, the pH, the temperature, and agitation. FaeB2 offered the highest transesterification yield (71...
January 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28078395/high-production-of-2-3-butanediol-from-glycerol-without-1-3-propanediol-formation-by-raoultella-ornithinolytica-b6
#9
Taeyeon Kim, Sukhyeong Cho, Han Min Woo, Sun-Mi Lee, Jinwon Lee, Youngsoon Um, Jin-Ho Seo
Conversion of crude glycerol derived from biodiesel processes to value-added chemicals has attracted much attention. Herein, Raoultella ornithinolytica B6 was investigated for the high production of 2,3-butanediol (2,3-BD) from glycerol without 1,3-propanediol (1,3-PD) formation, a by-product hindering 2,3-BD purification. By evaluating the effects of temperature, agitation speed, and pH control strategy, the fermentation conditions favoring 2,3-BD production were found to be 25 °C, 400 rpm, and pH control with a lower limit of 5...
January 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28078203/catatonia-our-current-understanding-of-its-diagnosis-treatment-and-pathophysiology
#10
REVIEW
Sean A Rasmussen, Michael F Mazurek, Patricia I Rosebush
Catatonia is a psychomotor syndrome that has been reported to occur in more than 10% of patients with acute psychiatric illnesses. Two subtypes of the syndrome have been identified. Catatonia of the retarded type is characterized by immobility, mutism, staring, rigidity, and a host of other clinical signs. Excited catatonia is a less common presentation in which patients develop prolonged periods of psychomotor agitation. Once thought to be a subtype of schizophrenia, catatonia is now recognized to occur with a broad spectrum of medical and psychiatric illnesses, particularly affective disorders...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28076656/combined-inhaled-beta-agonist-and-anticholinergic-agents-for-emergency-management-in-adults-with-asthma
#11
REVIEW
Scott W Kirkland, Christine Vandenberghe, Britt Voaklander, Taylor Nikel, Sandra Campbell, Brian H Rowe
BACKGROUND: Inhaled short-acting anticholinergics (SAAC) and short-acting beta₂-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA treatment is more effective in reducing hospitalisations compared to treatment with SABA alone. OBJECTIVES: To conduct an up-to-date systematic search and meta-analysis on the effectiveness of combined inhaled therapy (SAAC + SABA agents) vs...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28076483/sedation-in-colonoscopy-by-using-three-different-propofol-infusion-methods-and-analysis-of-plasma-concentration-levels-a-prospective-comparative-study
#12
Paulo Henrique Boaventura de Carvalho, José Pinhata Otoch, Mohamad Ali Khan, Paulo Sakai, Hugo Gonçalo Guedes, Everson Luiz de Almeida Artifon
Background: The propofolemia becomes directly linked to the clinical effects of this anesthetic and is the focus for studies comparing propofol clinical use, in different administration methods routinely used in endoscopy units where sedation is widely administered to patients. Aim: To evaluate the effects of three different regimens of intravenous propofol infusion in colonoscopies. Methods: A total of 50 patients that underwent colonoscopies were consecutively assigned to three groups: 1) intermittent bolus infusion; 2) continuous manually controlled infusion; 3) continuous automatic infusion...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28076462/effect-of-ultrasonic-streaming-on-intra-dentinal-disinfection-and-penetration-of-calcium-hydroxide-paste-in-endodontic-treatment
#13
Marcela Paola Castro Arias, Amanda Garcia Alves Maliza, Raquel Zanin Midena, Márcia Sirlene Zardin Graeff, Marco Antonio Húngaro Duarte, Flaviana Bombarda de Andrade
Objective: The antimicrobial effect of ultrasonic agitation of calcium hydroxide (CH) pastes in infected bovine dentin and their penetrability were evaluated using confocal laser scanning microscopy (CLSM) and microbiological culture. Material and Methods: Fifty-two bovine teeth were infected with Enterococcus faecalis using a new contamination protocol; then they received CH paste and were divided into groups with or without ultrasound. Ultrasonic agitation was conducted for 1 min with a plain point insert...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28075189/11-analytically-confirmed-cases-of-mexedrone-use-among-polydrug-users
#14
Liam Roberts, Loretta Ford, Neel Patel, J Allister Vale, Sally M Bradberry
INTRODUCTION: Mexedrone, 3-methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one, is the alpha-methoxy-derivative of mephedrone (4-methyl-N-methyl cathinone). Mexedrone inhibits the re-uptake of serotonin and dopamine in a dose-dependent manner and has affinity for serotonin and dopamine membrane transporters and receptors (5-HT2 and D2 receptors), producing sympathomimetic effects similar to amfetamines. To date there are no published clinical reports on mexedrone use that are analytically confirmed...
January 11, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28074804/outcome-of-four-pretreatment-regimes-on-hemodynamics-during-electroconvulsive-therapy-a-double-blind-randomized-controlled-crossover-trial
#15
Devangi Ashutosh Parikh, Sanchita Nitin Garg, Naina Parag Dalvi, Priyanka Pradip Surana, Deepa Sannakki, Bharati Anil Tendolkar
CONTEXT: Electroconvulsive therapy (ECT) is associated with tachycardia and hypertension. AIMS: The aim of this study was to compare two doses of dexmedetomidine, esmolol, and lignocaine with respect to hemodynamics, seizure duration, emergence agitation (EA), and recovery profile. METHODOLOGY: Thirty patients undergoing ECT were assigned to each of the following pretreatment regimes over the course of five ECT sessions in a randomized crossover design: Group D1 (dexmedetomidine 1 μg/kg), Group D0...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28074297/-delirium-analgesia-and-sedation-in-intensive-care-medicine-development-of-a-protocol-based-management-approach
#16
A Wolf, R Mörgeli, A Müller, B Weiss, C Spies
Intensive care treatment has long-term consequences that are often not immediately apparent to the health care providers. The combination of muscle weakness, cognitive damage, and psychological disorders is comprised under the term post-intensive care syndrome (PICS). Analgesia and sedation protocols, as well as nonpharmacological preventive and therapeutic approaches, are effective tools for avoiding complications and improving long-term survival. The principle of "early goal-directed therapy" is fundamental...
January 10, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28069271/how-is-depression-experienced-around-the-world-a-systematic-review-of-qualitative-literature
#17
E E Haroz, M Ritchey, J K Bass, B A Kohrt, J Augustinavicius, L Michalopoulos, M D Burkey, P Bolton
To date global research on depression has used assessment tools based on research and clinical experience drawn from Western populations (i.e., in North American, European and Australian). There may be features of depression in non-Western populations which are not captured in current diagnostic criteria or measurement tools, as well as criteria for depression that are not relevant in other regions. We investigated this possibility through a systematic review of qualitative studies of depression worldwide. Nine online databases were searched for records that used qualitative methods to study depression...
December 22, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28069226/synthesis-of-carbon-loaded-%C3%AE-fe2o3-nanocomposite-and-their-applicability-for-the-selective-removal-of-binary-mixture-of-dyes-by-ultrasonic-adsorption-based-on-response-surface-methodology
#18
Muhammad Saad, Hajira Tahir
The contemporary problems concerning water purification could be resolved by using nanosorbents. The present studies emphasis on the synthesis of γ-Fe2O3-activated carbon nanocomposites (γ-Fe2O3-NP-AC) by sol-gel method. The composition and surface morphology of them were studied by FTIR, EDS, SEM and XRD techniques. Moreover they were employed for the selective removal of binary mixture of dyes including reactive red 223 dye (RR) and Malachite Green dye (MG) by ultrasonic assisted adsorption method. Sonication is the act of applying sound energy to agitate particles in the sample...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28069203/drastic-acceleration-of-fibrillation-of-insulin-by-transient-cavitation-bubble
#19
Kichitaro Nakajima, Daisuke Nishioka, Masahiko Hirao, Masatomo So, Yuji Goto, Hirotsugu Ogi
Amyloid-fibril formation of proteins can be accelerated by ultrasonic irradiation to the peptide solutions. Although this phenomenon contributes to understanding pathogenic behavior of amyloidosis, its physical mechanism has not been clarified, because several factors (cavitation, temperature increase, stirring effect, and so on) related to ultrasonic irradiation can participate in the fibrillation reaction. Here, we independently study contributions of the possible factors, using insulin, which is extremely stable and then suitable for the mechanism clarification...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067961/quality-of-life-in-relation-to-neuropsychiatric-symptoms-in-alzheimer-s-disease-5-year-prospective-alsova-cohort-study
#20
Kristiina Hongisto, Ilona Hallikainen, Tuomas Selander, Soili Törmälehto, Saku Väätäinen, Janne Martikainen, Tarja Välimäki, Sirpa Hartikainen, Jaana Suhonen, Anne M Koivisto
OBJECTIVE: To examine the association between neuropsychiatric symptoms (NPS) with self- and caregiver-rated Quality of Life (QoL) for patients with Alzheimer's disease (AD) during a 5-year follow-up. METHODS: The ALSOVA 5-year follow-up study included, at baseline, 236 patients with either very mild (Clinical Dementia Rating Scale (CDR) 0.5), or mild (CDR 1) AD, together with their caregivers from three Finnish hospital districts. QoL was evaluated using patient self-reported, and caregiver-rated, QoL in AD (QoL-AD) scores...
January 9, 2017: International Journal of Geriatric Psychiatry
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