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https://www.readbyqxmd.com/read/29143649/modelling-stunting-in-list-the-effect-of-applying-smoothing-to-linear-growth-data
#1
Simon Cousens, Jamie Perin, Parul Christian, Lee Shu-Fune Wu, Sajid Soofi, Zulfiqar Bhutta, Claudio Lanata, Richard L Guerrant, Aldo A M Lima, Kåre Mølbak, Palle Valentiner-Branth, William Checkley, Robert H Gilman, R Bradley Sack, Robert E Black, Jean Humphrey, Neff Walker
BACKGROUND: The Lives Saved Tool (LiST) is a widely used resource for evidence-based decision-making regarding health program scale-up in low- and middle-income countries. LiST estimates the impact of specified changes in intervention coverage on mortality and stunting among children under 5 years of age. We aimed to improve the estimates of the parameters in LiST that determine the rate at which the effects of interventions to prevent stunting attenuate as children get older. METHODS: We identified datasets with serial measurements of children's lengths or heights and used random effects models and restricted cubic splines to model the growth trajectories of children with at least six serial length/height measurements...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29138840/low-dosage-of-arsenic-trioxide-inhibits-vasculogenic-mimicry-in-hepatoblastoma-without-cell-apoptosis
#2
Feng Zhang, Chun-Mei Zhang, Shu Li, Kun-Kun Wang, Bin-Bin Guo, Yao Fu, Lu-Yang Liu, Yu Zhang, Hai-Yu Jiang, Chang-Jun Wu
Hepatoblastoma (HB) is the most common type of pediatric liver malignancy, which predominantly occurs in young children (aged <5 years), and continues to be a therapeutic challenge in terms of metastasis and drug resistance. As a new pattern of tumor blood supply, vasculogenic mimicry (VM) is a channel structure lined by tumor cells rather than endothelial cells, which contribute to angiogenesis. VM occurs in a variety of solid tumor types, including liver cancer, such as hepatocellular carcinoma. The aim of the present study was to elucidate the effect of arsenic trioxide (As2O3) on VM...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29122090/prevalence-and-years-of-life-lost-due-to-disability-from-dental-caries-among-children-and-adolescents-in-western-china-1990-2015
#3
Zhuo Wang, Ying Deng, Shi Wei Liu, Jun He, Kui Ji, Xin Ying Zeng, Shu Juan Yang, Xin Yin Xu, Yu Luo, Mai Geng Zhou, Jian Xin Zhang
OBJECTIVE: To analyze the prevalence and years lived with disability (YLD) from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. METHODS: Based on the Global Burden of Disease Study 2015 (GBD2015), which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China...
2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29120854/the-protective-effects-of-bacillus-licheniformis-preparation-on-gastrointestinal-disorders-and-inflammation-induced-by-radiotherapy-in-pediatric-with-central-nervous-system-tumor
#4
Shu-Xu Du, Yong-Rui Jia, Si-Qi Ren, Xiao-Jun Gong, Hong Tang, Wu Wan-Shui, Sun Li-Ming
PURPOSE: we studied the effect of Bacillus licheniformis preparation (ZCS) on CNST (central nervous system tumor) patients undergoing the gastrointestinal symptoms and inflammation induced by radiotherapy. MATERIALS AND METHODS: 160 CNST patients with craniospinal irradiation (CSI) treatment were divided into experiment and control group. The experiment group patients took one capsule per time of ZCS and three times a day until the end of radiotherapy, starting one day before radiotherapy...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29109476/the-major-targets-of-acute-norovirus-infection-are-immune-cells-in-the-gut-associated-lymphoid-tissue
#5
Katrina R Grau, Alexa N Roth, Shu Zhu, Abel Hernandez, Natacha Colliou, Bayli B DiVita, Drake T Philip, Cara Riffe, Benoit Giasson, Shannon M Wallet, Mansour Mohamadzadeh, Stephanie M Karst
Noroviruses are the leading cause of food-borne gastroenteritis outbreaks and childhood diarrhoea globally, estimated to be responsible for 200,000 deaths in children each year (1-4) . Thus, reducing norovirus-associated disease is a critical priority. Development of vaccines and therapeutics has been hindered by the limited understanding of basic norovirus pathogenesis and cell tropism. While macrophages, dendritic cells, B cells and stem-cell-derived enteroids can all support infection of certain noroviruses in vitro (5-7) , efforts to define in vivo norovirus cell tropism have generated conflicting results...
November 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29098249/-effects-of-free-dental-filling-interventions-on-early-childhood-primary-tooth-caries-in-shanghai-jiading-district
#6
Hua Dong, Shu-Yu Zhang, Yue-Ling Li
PURPOSE: To provide scientific basis for the establishment of oral health care polices in Jiading, and to evaluate the effectiveness of a free dental filling intervention conducted for childen in Jiading district. METHODS: Nine hundred and eighteen children of 3-5 year old from two kindergartens with similarities in living environments and economic conditions were enrolled in this study. Children in the intervention group received both oral health examination and free filling of shallow and moderate caries once a year for 3 years, while children in the control group received only oral health examination once a year...
June 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29073472/epilepsy-may-be-the-major-risk-factor-of-mental-retardation-in-children-with-tuberous-sclerosis-a-retrospective-cohort-study
#7
Yang-Yang Wang, Ling-Yu Pang, Shu-Fang Ma, Meng-Na Zhang, Li-Ying Liu, Li-Ping Zou
Mental retardation (MR) is one of the most common cognitive comorbidities in children with tuberous sclerosis, and there are enormous studies about its risk factors. The genetic difference and the severity of epilepsy are the two main factors, but their weight in the occurrence of MR is still unclear. Two hundred twenty-three patients with tuberous sclerosis who received intelligence assessment, genetic mutation analysis, and the epilepsy severity assessment were included in our study. Genotype-neurocognitive phenotype correlations and epilepsy-neurocognitive phenotype correlations were analyzed by binary logistic regression analysis...
October 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29069373/detection-of-influenza-c-viruses-among-outpatients-and-patients-hospitalized-for-severe-acute-respiratory-infection-minnesota-2013-2016
#8
Beth K Thielen, Hannah Friedlander, Sarah Bistodeau, Bo Shu, Brian Lynch, Karen Martin, Erica Bye, Kathyrn Como-Sabetti, David Boxrud, Anna K Strain, Sandra S Chaves, Andrea Steffens, Ashley L Fowlkes, Stephen Lindstrom, Ruth Lynfield
Background: Existing literature suggests that influenza C typically causes mild respiratory tract disease. However, clinical and epidemiological data are limited. Methods: Four outpatient clinics and three hospitals submitted clinical data and respiratory specimens through a surveillance network for acute respiratory infection (ARI) during May 2013 through December 2016. Specimens were tested using multi-target nucleic acid amplification tests (NAAT) for 19-22 respiratory pathogens, including influenza C...
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29046200/-readmission-of-children-with-bronchopulmonary-dysplasia-in-the-first-2-years-of-life-a-clinical-analysis-of-121-cases
#9
Jing-Yi You, Chang Shu, Cai-Hui Gong, Sha Liu, Zhou Fu
OBJECTIVE: To investigate the clinical features of readmitted children with bronchopulmonary dysplasia (BPD) in the first 2 years of life. METHODS: A retrospective analysis was performed for the clinical data of 242 children with BPD who were readmitted due to recurrent lower respiratory tract infection (LRTI) in the first 2 years of life. RESULTS: Among all the 242 children with BPD, 115(47.5%) had wheezing, and the children aged 1-2 years had a significantly higher incidence rate of wheezing than those aged less than 1 year (P<0...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29028672/birth-cohort-consortium-of-asia-current-and-future-perspectives
#10
Reiko Kishi, Jun Jim Zhang, Eun-Hee Ha, Pau-Chung Chen, Ying Tian, Yankai Xia, Kenji J Tsuchiya, Kunihiko Nakai, Sungkyoon Kim, Soo-Jong Hong, Yun-Chul Hong, Jeong-Rim Lee, Hamid Jan B Jan Mohamed, Rajendra Prasad Parajuli, Linda S Adair, Yap Seng Chong, Yue Leon Guo, Shu-Li Wang, Muneko Nishijo, Teruhiko Kido, Pham The Tai, Sumal Nandasena
BACKGROUND: The environmental health of children is one of the great global health concerns. Exposures in utero and throughout development can have major consequences on later health. However, environmental risks or disease burdens vary from region to region. Birth cohort studies are ideal for investigating different environmental risks. METHODS: The principal investigators of three birth cohorts in Asia including the Taiwan Birth Panel Study (TBPS), the Mothers and Children's Environmental Health Study (MOCEH), and the Hokkaido Study on Environment and Children' Health (Hokkaido Study) coestablished the Birth Cohort Consortium of Asia (BiCCA) in 2011...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028671/prenatal-and-childhood-exposure-to-phthalate-diesters-and-thyroid-function-in-a-9-year-follow-up-birth-cohort-study-taiwan-maternal-and-infant-cohort-study
#11
Han-Bin Huang, Chia-Jui Chuang, Pen-Hua Su, Chien-Wen Sun, Chien-Jen Wang, Ming-Tsang Wu, Shu-Li Wang
BACKGROUND: Phthalates are widely used in industry, personal care products, and medications. Recent studies have suggested that phthalate exposure alters thyroid hormones. However, longitudinal studies concerning the association between phthalate exposure and thyroid function in children are scant. Therefore, we examined the association between pre- and postnatal phthalate exposure and thyroid function in children born in 2000-2001. METHODS: We studied 181 mother-child pairs in central Taiwan and followed-up the children from 2000 to 2009 at 2, 5, and 8 years old...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29020976/the-added-value-of-a-mobile-application-of-community-case-management-on-referral-re-consultation-and-hospitalization-rates%C3%A2-of-children-aged-under-5-years-in-two-districts-in-northern-malawi-study-protocol-for-a-pragmatic-stepped-wedge-cluster-randomized-controlled
#12
Victoria Hardy, Yvonne O'Connor, Ciara Heavin, Nikolaos Mastellos, Tammy Tran, John O'Donoghue, Annette L Fitzpatrick, Nicole Ide, Tsung-Shu Joseph Wu, Griphin Baxter Chirambo, Adamson S Muula, Moffat Nyirenda, Sven Carlsson, Bo Andersson, Matthew Thompson
BACKGROUND: There is evidence to suggest that frontline community health workers in Malawi are under-referring children to higher-level facilities. Integrating a digitized version of paper-based methods of Community Case Management (CCM) could strengthen delivery, increasing urgent referral rates and preventing unnecessary re-consultations and hospital admissions. This trial aims to evaluate the added value of the Supporting LIFE electronic Community Case Management Application (SL eCCM App) compared to paper-based CCM on urgent referral, re-consultation and hospitalization rates, in two districts in Northern Malawi...
October 11, 2017: Trials
https://www.readbyqxmd.com/read/29016306/case-report-bullous-scabies-in-two-children-below-10-years
#13
Ze-Yu Luo, Mei Zeng, Qian Gao, Yu-Kun Zhao, Rashmi Sarkar, Shu-Ping Liao, Di-Qing Luo
Bullous scabies is an infrequent and atypical presentation of scabies, with predilection for elderly and males. Its median age of presentation is 70 years. We report two male cases of bullous scabies who were 7 years and 6 months old. Both patients had excellent response to 10% sulfur ointment alone and have had no recurrence in more than 3 months of follow-up.
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994144/stereoacuity-measurement-using-a-phoropter-combined-with-two-4k-smartphones
#14
Huang Wu, Shu Liu, Ruiqing Wang
PURPOSE: To evaluate stereoacuity using a combination of a phoropter and two 4K smartphones. METHODS: A stereopsis measurement system was established using a phoropter (Topcon VT-10) and two Sony 4K smartphones (Sony Xperia Z5 Premium Dual E6883). A total of 154 subjects (69 children and 85 adults) were enrolled for evaluation using this system and subsequent comparison with the Fly Stereo Acuity test. RESULTS: There was a high level of agreement between the two methods using Bland-Altman statistical analysis (children group, 95 per cent limits of agreement ±0...
October 9, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28990296/association-between-mthfr-microrna-binding-site-polymorphisms-and-methotrexate-concentrations-in-chinese-pediatric-patients-with-acute-lymphoblastic-leukemia
#15
Shu-Mei Wang, Wei-Xin Zeng, Wan-Shui Wu, Lu-Lu Sun, Dan Yan
BACKGROUND: The pharmacokinetics and therapeutic response to methotrexate (MTX) display large variability in the treatment of acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the association of two microRNA (miRNA) binding site polymorphisms (rs3737966 G > A and rs35134728 DEL/TTC) in the 3'UTR of MTHFR with serum MTX concentrations, in a Chinese pediatric population with ALL. METHODS: Genotyping for MTHFR rs3737966 and rs35134728 in 144 children with ALL was performed using the Sequenom MassArray system...
October 9, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28982248/profiles-of-blood-pressure-among-children-and-adolescents-with-different-body-mass-index-categories-in-shandong-china
#16
Shu-Rong Wang, Yong-Bao Zhu, Yan Cheng, Ying-Xiu Zhang
BACKGROUND: The International Obesity Task Force recently developed an extended body mass index (BMI) cut-offs for screening thinness, overweight and obesity among children and adolescents. The present study examined the profiles of blood pressure (BP) among children and adolescents with different BMI categories in Shandong, China. METHODS: Data for this study were obtained from a large cross-sectional survey of schoolchildren. A total of 44,630 students (22,404 boys and 22,226 girls) aged 7-18 years participated in this study...
October 5, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28968276/sevoflurane-acts-on-ubiquitination-proteasome-pathway-to-reduce-postsynaptic-density-95-protein-levels-in-young-mice
#17
Han Lu, Ning Liufu, Yuanlin Dong, Guanghong Xu, Yiying Zhang, Liqi Shu, Sulpicio G Soriano, Hui Zheng, Buwei Yu, Zhongcong Xie
BACKGROUND: Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane, a commonly used anesthetic in children, has been reported to decrease levels of postsynaptic density 95 protein. However, the upstream mechanisms and downstream consequences of the sevoflurane-induced reduction in postsynaptic density 95 protein levels remains largely unknown. We therefore set out to assess whether sevoflurane acts on ubiquitination-proteasome pathway to facilitate postsynaptic density 95 protein degradation...
December 2017: Anesthesiology
https://www.readbyqxmd.com/read/28966683/diagnosis-and-treatment-of-gastric-duplication-in-children-a-case-report
#18
Lifeng Zhang, Qingjiang Chen, Zhigang Gao, Qixing Xiong, Qiang Shu
Gastric duplication is a rare congenital abnormality, and its diagnosis and treatment may be challenging in certain children. The present study reported four cases of gastric duplication who were followed-up and treated in the Children's Hospital of Zhejiang University between March 2010 and March 2015. The study aimed to increase the knowledge on this disease in order to improve the diagnosis and treatment, as well as decrease the possibility of misdiagnosis. Diagnosis could not be confirmed by the clinical manifestation, ultrasonography and computed tomography (CT)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28963295/associations-of-caesarean-delivery-and-the-occurrence-of-neurodevelopmental-disorders-asthma-or-obesity-in-childhood-based-on-taiwan-birth-cohort-study
#19
Ginden Chen, Wan-Lin Chiang, Bih-Ching Shu, Yue Leon Guo, Shu-Ti Chiou, Tung-Liang Chiang
OBJECTIVES: Whether birth by caesarean section (CS) increases the occurrence of neurodevelopmental disorders, asthma or obesity in childhood is controversial. We tried to demonstrate the association between children born by CS and the occurrence of the above three diseases at the age of 5.5 years. METHODS: The database of the Taiwan Birth Cohort Study which was designed to assess the developmental trajectories of 24 200 children born in 2005 was used in this study...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28945687/can-repeated-ponseti-management-for-relapsed-clubfeet-produce-the-outcome-comparable-with-the-case-without-relapse-a-clinical-study-in-term-of-gait-analysis
#20
Yu-Bin Liu, Shu-Yun Jiang, Li Zhao, Yan Yu, Da-Hang Zhao
BACKGROUND: The prevention and treatment of relapsed clubfoot remained challenging tasks. There were controversies as to treatment options and management, such as complete subtalar release, application of an Ilizarov external frame, or repeated Ponseti method; and different options were available in different treatment centers. This study was designed to evaluate the clinical outcome of relapsed clubfeet treated by repeated Ponseti method in comparison with the cases without relapse in term of gait analysis and to clarify the clinical efficacy of repeated Ponseti method in treating the relapsed clubfeet...
September 22, 2017: Journal of Pediatric Orthopedics
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