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https://www.readbyqxmd.com/read/29331260/multifaceted-behavior-of-meckel-s-diverticulum-in-children
#1
Qingjiang Chen, Zhigang Gao, Lifeng Zhang, Yuebin Zhang, Tao Pan, Duote Cai, Qixing Xiong, Qiang Shu, Yunzhong Qian
PURPOSE/BACKGROUND: Meckel's diverticulum (MD) is one of the most common congenital malformations of gastrointestinal tract in children. However, the nonspecific clinical manifestations of MD often cause a diagnostic as well as therapeutic challenge to pediatric surgeon. This study aimed to review our experience in managing this disease while evaluating the management strategies. METHODS: We retrospectively analyzed the clinical data of all patients diagnosed with MD admitted to our center between January 2010 and December 2015...
December 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29327543/-management-of-displaced-radial-neck-fractures-in-children-elastic-stable-intramedullary-nailing-vs-k-wire-fixation
#2
Quan-Zhou Wu, Shu-Ming Huang, Qi-Xun Cai, Xu-Feng Chu
OBJECTIVE: To compare the complications and clinical outcome of titanium elastic nail(TEN) versus K-wire fixation(KW) for the treatment of displaced radial neck fractures in children. METHODS: From January 2009 to December 2014, 56 children with displaced radial neck fractures were studied retrospectively according to the inclusion criteria. Based on the different methods of internal fixation, patients were divided into two groups: titanium elastic nail (TEN group) and K-wire fixation (KW group)...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29321080/prenatal-vitamin-d-status-and-offspring-s-growth-adiposity-and-metabolic-health-a-systematic-review-and-meta-analysis
#3
Christina Santamaria, Wei Guang Bi, Line Leduc, Negar Tabatabaei, Prévost Jantchou, Zhong-Cheng Luo, François Audibert, Anne Monique Nuyt, Shu Qin Wei
In this systematic review and meta-analysis of observational studies, we aimed to estimate the associations between prenatal vitamin D status and offspring growth, adiposity and metabolic health. We searched the literature in human studies on prenatal vitamin D status and offspring growth in PubMed, up to July 2017. Studies were selected according to their methodological quality and outcomes of interest (anthropometry, fat mass and diabetes in offspring). The inverse variance method was used to calculate the pooled mean difference (MD) with 95 % CI for continuous outcomes, and the Mantel-Haenszel method was used to calculate the pooled OR with 95 % CI for dichotomous outcomes...
January 11, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29315158/increased-incidence-of-obstructive-sleep-apnea-in-hospitalized-children-following-enterovirus-infection-a-nationwide-population-based-cohort-study
#4
Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Yu-Shu Huang, Chung-Yao Hsu
BACKGROUND: We report the first nationwide population-based cohort study using Taiwan's National Health Insurance Research Database on the association between enterovirus infection and the incidence of sleep disorders in a pediatric population. METHODS: Two matched groups of children under 18 years of age were included in the analyses for non-apneic sleep disorder and obstructive sleep apnea (OSA). Among them, 316 subjects were diagnosed with OSA during the surveillance period, including 182 in the EV infection group and 134 in the non-EV infection group...
January 8, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29306656/association-between-a-microrna-binding-site-polymorphism-in-slco1a2-and-the-risk-of-delayed-methotrexate-elimination-in-chinese-children-with-acute-lymphoblastic-leukemia
#5
Shu-Mei Wang, Wei-Xin Zeng, Wan-Shui Wu, Lu-Lu Sun, Dan Yan
Organic anion-transporting polypeptide 1A2 (OATP1A2) is involved in the cellular uptake of methotrexate (MTX). Genetic variation in solute carrier organic anion transporter family member 1A2 (SLCO1A2, the coding gene of OATP1A2) has important implications for the elimination of MTX. We investigated the association between a microRNA (miRNA) binding site polymorphism (rs4149009 G > A) in the 3'-untranslated region (3'-UTR) of SLCO1A2 with the serum MTX concentrations in Chinese children with acute lymphoblastic leukemia (ALL)...
January 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29282039/plasma-levels-of-alarmin-hnps-1-3-associate-with-lung-dysfunction-after-cardiac-surgery-in-children
#6
XiWang Liu, QiXing Chen, YuJia Luo, YaoQin Hu, DengMing Lai, XiaoLe Zhang, XiangHong Zhang, JianGen Yu, XiangMing Fang, Qiang Shu
BACKGROUND: Early onset of lung injury is considerable common after cardiac surgery and is associated with increasing in morbidity and mortality, but current clinical predictors for the occurrence of this complication always have limited positive warning value. This study aimed to evaluate whether elevated plasma levels of human neutrophil peptides (HNPs) 1-3 herald impaired lung function in infants and young children after cardiac surgery necessitating cardiopulmonary bypass (CPB). METHODS: Consecutive children younger than 3 years old who underwent cardiac surgery were prospectively enrolled...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29273115/cost-effectiveness-of-a-savings-led-economic-empowerment-intervention-for-aids-affected-adolescents-in-uganda-implications-for-scale-up-in-low-resource-communities
#7
Fred M Ssewamala, Julia Shu-Huah Wang, Torsten B Neilands, Laura Gauer Bermudez, Irwin Garfinkel, Jane Waldfogel, Jeanne Brooks-Gunn, Gwyneth Kirkbride
PURPOSE: Nearly 12 million children and adolescents in sub-Saharan Africa have lost one or both parents to AIDS. Within sub-Saharan Africa, Uganda has been greatly impacted, with an estimated 1.2 million orphaned children, nearly half of which have experienced parental loss due to the epidemic. Cost-effective and scalable interventions are needed to improve developmental outcomes for these children, most of whom are growing up in poverty. This article examines the direct impacts and cost-effectiveness of a savings-led family economic empowerment intervention, Bridges to the Future, that employed varying matched savings incentives to encourage investment in Ugandan children orphaned by AIDS...
January 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29245219/a-novel-germline-mutation-c-a527g-in-stk11-gene-causes-peutz-jeghers-syndrome-in-a-chinese-girl-a-case-report
#8
Zi-Ye Zhao, Yu-Liang Jiang, Bai-Rong Li, Fu Yang, Jing Li, Xiao-Wei Jin, Shu-Han Sun, Shou-Bin Ning
RATIONALE: Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. PATIENT CONCERNS: A girl with a positive family history grew oral pigmentation at 1 and got intussusception by small bowel hamartomas at 5...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241433/long-run-trends-in-antidepressant-use-among-youths-after-the-fda-black-box-warning
#9
Nilay Kafali, Ana Progovac, Sherry Shu-Yeu Hou, Benjamin Lê Cook
OBJECTIVE: In October 2004, the Food and Drug Administration directed pharmaceutical companies to issue a black box warning about the potential link between the use of antidepressants and suicidal ideation among children. This study analyzed long-run trends in antidepressant use among children before and after the black box warning for those with and without severe psychological impairment. METHODS: The analysis used data from the Medical Expenditure Panel Survey for children ages five to 17, covering years 2000-2011 (N=75,819)...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29237523/-clinical-analysis-of-15%C3%A2-851-children-at-risk-of-inherited-metabolic-diseases
#10
Shu-Xiang Lin, Jian-Bo Shu, Chao Wang, Rui Pan, Ying-Tao Meng, Chun-Hua Zhang, Bi-Li Zhang, Dan Wang, Yu-Qin Zhang
OBJECTIVE: To explore the value of urine gas chromatography-mass spectrometry (GC-MS) in the screening of children at risk of inherited metabolic diseases (IMD), and to identify the disease spectrum of IMD and the clinical characteristics of children with IMD. METHODS: The clinical data of 15 851 children at risk of IMD who underwent urine GC-MS in the Tianjin Children's Hospital between February 2012 and December 2016 were retrospectively analyzed. RESULTS: In the 15 851 children, 5 793 (36...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29220742/meta-analyses-of-newer-antiepileptic-drugs-as-adjunct-for-treatment-of-focal-epilepsy-in-children
#11
Nurul-Ain Mohd-Tahir, Shu-Chuen Li
AIM: This study conducted a systematic review evaluating the effectiveness of newer antiepileptic drugs (AEDs) (namely, lamotrigine, levetiracetam, topiramate, vigabatrin, zonisamide, oxcarbazepine, perampanel, gabapentin, and stiripentol) as add-on for treatment of focal epilepsy in children. METHODS: Articles were retrieved from EMBASE, Medline and Cochrane Library from inception to January 2016. Treatment outcomes were analysed based on responder, seizure-free, withdrawal and adverse event rates...
November 22, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29214503/epidemiology-and-clinical-characteristics-of-human-coronaviruses-oc43-229e-nl63-and-hku1-a-study-of-hospitalized-children-with-acute-respiratory-tract-infection-in-guangzhou-china
#12
Zhi-Qi Zeng, De-Hui Chen, Wei-Ping Tan, Shu-Yan Qiu, Duo Xu, Huan-Xi Liang, Mei-Xin Chen, Xiao Li, Zheng-Shi Lin, Wen-Kuan Liu, Rong Zhou
Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR)...
December 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29176136/plasma-neuropeptide-y-levels-in-vasovagal-syncope-in-children
#13
Ying Liao, Wen-Rui Xu, Hong-Xia Li, Chao-Shu Tang, Hong-Fang Jin, Jun-Bao Du
BACKGROUND: Vasovagal syncope (VVS) is the most common cause of syncope in children. Neuropeptide Y (NPY) plays an important role in the regulation of blood pressure (BP), as well as myocardial contractility. This study aimed to explore the role of plasma NPY in VVS in children. METHODS: Fifty-six children who were diagnosed with VVS (VVS group) using head-up tilt test (HUT) and 31 healthy children who were selected as controls (control group) were enrolled. Plasma NPY concentrations were detected...
December 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29175108/nonstructural-protein-2a-modulates-replication-and-virulence-of-enterovirus-71
#14
Chun Li, Qiao Qiao, Shu-Bin Hao, Zhen Dong, Li Zhao, Jing Ji, Zhi-Yu Wang, Hong-Ling Wen
Enterovirus 71 (EV71) can cause hand, foot, and mouth disease in children, and severe infections can induce neurological complications and even death. However, the pathogenesis of EV71 remains unknown. The 2A proteinase (2Apro) of EV71 plays an important role in segmenting the precursor polyprotein during viral replication, inhibiting host protein synthesis, and evading innate immunity. This study was to determine the function of EV71 2Apro in replication and virulence. A chimeric strain (SDLY 107-2A-1) was recombined by replacing 2Apro of a severe strain (SDLY107) with that of a mild strain (SDLY1) based on an infectious cDNA clone...
November 21, 2017: Virus Research
https://www.readbyqxmd.com/read/29167083/the-effect-of-diagnostic-blood-loss-on-anemia-and-transfusion-among-postoperative-patients-with-congenital-heart-disease-in-a-pediatric-intensive-care-unit
#15
Dan Zhou, Yu-Lan Luo, Shu-Hua Luo, Mei Feng, Meng-Lin Tang
PURPOSE: To evaluate whether diagnostic blood loss can lead to anemia and consequent blood transfusion among postoperative patients with congenital heart disease (CHD) in the pediatric intensive care unit (PICU). DESIGN AND METHODS: This prospective observational study was conducted in a university-affiliated tertiary hospital between January and August 2016. CHD patients aged <12years, undergoing cardiac surgery, with a PICU stay >48h were included (n=205)...
November 4, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29143649/modelling-stunting-in-list-the-effect-of-applying-smoothing-to-linear-growth-data
#16
Simon Cousens, Jamie Perin, Parul Christian, Lee Shu-Fune Wu, Sajid Soofi, Zulfiqar Bhutta, Claudio Lanata, Richard L Guerrant, Aldo A M Lima, Kåre Mølbak, Palle Valentiner-Branth, William Checkley, Robert H Gilman, R Bradley Sack, Robert E Black, Jean Humphrey, Neff Walker
BACKGROUND: The Lives Saved Tool (LiST) is a widely used resource for evidence-based decision-making regarding health program scale-up in low- and middle-income countries. LiST estimates the impact of specified changes in intervention coverage on mortality and stunting among children under 5 years of age. We aimed to improve the estimates of the parameters in LiST that determine the rate at which the effects of interventions to prevent stunting attenuate as children get older. METHODS: We identified datasets with serial measurements of children's lengths or heights and used random effects models and restricted cubic splines to model the growth trajectories of children with at least six serial length/height measurements...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29138840/low-dosage-of-arsenic-trioxide-inhibits-vasculogenic-mimicry-in-hepatoblastoma-without-cell-apoptosis
#17
Feng Zhang, Chun-Mei Zhang, Shu Li, Kun-Kun Wang, Bin-Bin Guo, Yao Fu, Lu-Yang Liu, Yu Zhang, Hai-Yu Jiang, Chang-Jun Wu
Hepatoblastoma (HB) is the most common type of pediatric liver malignancy, which predominantly occurs in young children (aged <5 years), and continues to be a therapeutic challenge in terms of metastasis and drug resistance. As a new pattern of tumor blood supply, vasculogenic mimicry (VM) is a channel structure lined by tumor cells rather than endothelial cells, which contribute to angiogenesis. VM occurs in a variety of solid tumor types, including liver cancer, such as hepatocellular carcinoma. The aim of the present study was to elucidate the effect of arsenic trioxide (As2O3) on VM...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29122090/prevalence-and-years-of-life-lost-due-to-disability-from-dental-caries-among-children-and-adolescents-in-western-china-1990-2015
#18
Zhuo Wang, Ying Deng, Shi Wei Liu, Jun He, Kui Ji, Xin Ying Zeng, Shu Juan Yang, Xin Yin Xu, Yu Luo, Mai Geng Zhou, Jian Xin Zhang
OBJECTIVE: To analyze the prevalence and years lived with disability (YLD) from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. METHODS: Based on the Global Burden of Disease Study 2015 (GBD2015), which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China...
2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29120854/the-protective-effects-of-bacillus-licheniformis-preparation-on-gastrointestinal-disorders-and-inflammation-induced-by-radiotherapy-in-pediatric-with-central-nervous-system-tumor
#19
Shu-Xu Du, Yong-Rui Jia, Si-Qi Ren, Xiao-Jun Gong, Hong Tang, Wu Wan-Shui, Sun Li-Ming
PURPOSE: we studied the effect of Bacillus licheniformis preparation (ZCS) on CNST (central nervous system tumor) patients undergoing the gastrointestinal symptoms and inflammation induced by radiotherapy. MATERIALS AND METHODS: 160 CNST patients with craniospinal irradiation (CSI) treatment were divided into experiment and control group. The experiment group patients took one capsule per time of ZCS and three times a day until the end of radiotherapy, starting one day before radiotherapy...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29109476/the-major-targets-of-acute-norovirus-infection-are-immune-cells-in-the-gut-associated-lymphoid-tissue
#20
Katrina R Grau, Alexa N Roth, Shu Zhu, Abel Hernandez, Natacha Colliou, Bayli B DiVita, Drake T Philip, Cara Riffe, Benoit Giasson, Shannon M Wallet, Mansour Mohamadzadeh, Stephanie M Karst
Noroviruses are the leading cause of food-borne gastroenteritis outbreaks and childhood diarrhoea globally, estimated to be responsible for 200,000 deaths in children each year 1-4 . Thus, reducing norovirus-associated disease is a critical priority. Development of vaccines and therapeutics has been hindered by the limited understanding of basic norovirus pathogenesis and cell tropism. While macrophages, dendritic cells, B cells and stem-cell-derived enteroids can all support infection of certain noroviruses in vitro 5-7 , efforts to define in vivo norovirus cell tropism have generated conflicting results...
December 2017: Nature Microbiology
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