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SHU In childrens

Shu-E Soh, Anne Goh, Oon Hoe Teoh, Keith M Godfrey, Peter D Gluckman, Lynette Pei-Chi Shek, Yap-Seng Chong
Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1⁻4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study ( n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2...
May 15, 2018: International Journal of Environmental Research and Public Health
Gui Yang, Shu Qi Qiu, Peng Wang, Dan Chen, Sheng Li, Tian Yong Hu, Li Ma, Zhi Qiang Liu
Objective: To analyze the impact of sublingual immunotherapy(SLIT)on the quality of life in children with allergic rhinitis. Method: Fifty children with allergic rhinitis who have received sublingual immunotherapy were enrolled in this study.Quality of life was evaluated via measurement of VAS score and rhinoconjunctivitis quality of life questionnaire(RQLQ)before and after treatment. Result: Twenty patients after treatment had complete remission,13 cases were partly alleviated and 17 cases had no response...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Yung-Sung Lee, Lai-Chu See, Shu-Hao Chang, Nan-Kai Wang, Yih-Shiou Hwang, Chi-Chun Lai, Kuan-Jen Chen, Wei-Chi Wu
PURPOSE: To investigate the macular structures, optical components, and visual acuity in preschool-aged children with a history of type I retinopathy of prematurity who underwent either intravitreal bevacizumab (IVB), laser, or a combination of treatments. DESIGN: Comparative interventional case series. METHODS SETTING: A referred medical center in Taiwan. STUDY POPULATION: 80 eyes from 42 patients (33 IVB-treated eyes from 17 children, 24 laser-treated eyes from 13 children, and 23 laser + IVB-treated eyes from 12 children)...
May 10, 2018: American Journal of Ophthalmology
Yuan Ding, Lina Zhou, Yu Xia, Wei Wang, Ying Wang, Li Li, Zhongxiang Qi, Linqing Zhong, Jinqiao Sun, Wenjing Tang, Fangfang Liang, Haijuan Xiao, Tao Qin, Ying Luo, Xuezhen Zhao, Zhou Shu, Ying Ru, Rongxin Dai, Hong Wang, Yanping Wang, Yongjie Zhang, Suqian Zhang, Cong Gao, Hongqiang Du, Xuan Zhang, Zhaolong Chen, Xiaochuan Wang, Hongmei Song, Jun Yang, Xiaodong Zhao
This multi-centered study provides detailed immunophenotyping of peripheral blood lymphocyte subpopulations in a large cohort of children from China, and serves as an important ethnic and age-specific reference tool for evaluation of immune abnormalities.
May 7, 2018: Journal of Allergy and Clinical Immunology
Karene Hoi Ting Yeung, Kate Ching Ching Chan, Paul K S Chan, David Shu Yan Lam, Philip Chak On Sham, Yat Sun Yau, Wai Hung Chan, Wa Keung Chiu, Kwok Leung Ng, Daniel Kwok Keung Ng, Iris Mei Ching Chan, E Anthony S Nelson
BACKGROUND: Hong Kong has a high burden of influenza hospitalisation. This study estimated influenza vaccine effectiveness in hospitalised Hong Kong children aged 6 months to below 6 years using data potentially obtainable from routine surveillance sources. METHODS: This 'test-negative' case-control study was conducted over two summer and one winter influenza seasons in five public Hong Kong hospitals during 2015 and 2016. Patients admitted for febrile and/or respiratory-associated illnesses who met inclusion criteria were invited to participate...
May 5, 2018: Vaccine
Xiu-Guo Han, Hui-Min Mo, Xu-Qiang Liu, Yan Li, Lin Du, Han Qiao, Qi-Ming Fan, Jie Zhao, Shu-Hong Zhang, Ting-Ting Tang
Osteosarcoma is the most common bone cancer in children and adolescents. Tissue inhibitors of metalloproteinases (TIMPs)-3 inhibit matrix metalloproteinases to limit extracellular matrix degradation. Cisplatin is a widely used chemotherapeutic drug used to cure osteosarcoma. Interleukin (IL)-6 and TIMP3 play important roles in the drug resistance of osteosarcoma; however, their relationship in this process remains unclear. This study aimed to explore the role of TIMP3 in the cisplatin sensitivity of osteosarcoma and its underlying molecular mechanisms in vitro and in vivo ...
2018: Frontiers in Genetics
Mengmeng Su, Jingjing Zhao, Michel Thiebaut de Schotten, Wei Zhou, Gaolang Gong, Franck Ramus, Hua Shu
Chinese is a logographic language that is different from alphabetic languages in visual and semantic complexity. Thus far, it is still unclear whether Chinese children with dyslexia show similar disruption of white matter pathways as in alphabetic languages. The present study focused on the alteration of white matter pathways in Chinese children with dyslexia. Using diffusion tensor imaging tractography, the bilateral arcuate fasciculus (AF-anterior, AF-posterior and AF-direct segments), inferior fronto-occipital fasciculus (IFOF) and inferior longitudinal fasciculus (ILF) were delineated in each individual's native space...
April 13, 2018: Developmental Cognitive Neuroscience
Jenn-Tzong Chang, Yao-Shen Chen, Bao-Chen Chen, Tsi-Shu Huang, Tsung-Hsien Chang
To understand human parechovirus (HPeV) infections in Taiwanese children, we analyzed data for 112 children (age ≤ 10 years) with HPeV infection diagnosed from July 2007 to June 2016 in a medical centre in Kaohsiung, southern Taiwan. Infection was with HPeV1 (n=94), HPeV3 (n=3), HPeV4 (n=3), HPeV6 (n=1) and non-typeable HPeV (n=11). We compared the clinical implication for children younger than 3 months (n=56) and 3 months and older (n=31), excluding the 25 children with concomitant infection. Fever was noted in almost half of the children younger than 3 months but was more frequent in older than younger children (83...
April 27, 2018: Japanese Journal of Infectious Diseases
Tai-Hsin Hung, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ching-Shu Tsai, Mong-Liang Lu, Roger S McIntyre, Yena Lee, Kuo-You Huang
BACKGROUND AND AIMS: Delay and impairment in Speech and language are common developmental problems in younger populations. Hitherto, there has been minimal study of the association between common childhood infections (e.g. enterovirus [EV]) and speech and language. The impetus for evaluating this association is provided by evidence linking inflammation to neurodevelopmental disorders. Herein we sought to determine whether an association exists between EV infection and subsequent diagnoses of speech and language impairments in a nationwide population-based sample in Taiwan...
April 26, 2018: Research in Developmental Disabilities
Shu-Hui Peng, Chun-Ying Huang, Shiun-Yuan Hsu, Li-Hui Yang, Ching-Hua Hsieh
Background : This study aimed to profile the epidemiology of injury among preschool-aged and school-aged children in comparison to those in adults. Methods : According to the Trauma Registry System of a level I trauma center, the medical data were retrieved from 938 preschool-aged children (aged less than seven years), 670 school-aged children (aged 7⁻12 years), and 16,800 adults (aged 20⁻64 years) between 1 January 2009 and 31 December 2016. Two-sided Pearson’s, chi-squared, and Fisher’s exact tests were used to compare categorical data...
April 25, 2018: International Journal of Environmental Research and Public Health
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
Wen-Bin Cao, Jian-Feng Yao, Si-Zhou Feng, Yi He, Er-Lie Jiang, Rong-Li Zhang, Dong-Lin Yang, Ming Gong, Xiao-Hui Zheng, Shu-Lian Chen, Jia-Li Sun, Lu-Kun Zhou, Ming-Zhe Han
Philadelphia chromosome (Ph)/BCR-ABL-positive (ph+ ) ALL is the most common genetic abnormality associated with ALL and has been shown to confer the worst prognosis to both children and adults. Increasing evidence has revealed that the dysregulation of prolyl isomerase Pin 1 contributes to multicancer development and progression, including ALL, although the underlying molecular mechanisms remain unclear. Here, we report that the expression of Pin 1 was enhanced in ph+ ALL patient samples and was associated positively with the expression of BCR-ABL...
April 17, 2018: Cancer Medicine
Wei-Te Lei, Po-Li Tsai, Szu-Hung Chu, Yu-Hsuan Kao, Chien-Yu Lin, Li-Ching Fang, Shyh-Dar Shyur, Yu-Wen Lin, Shu-I Wu
BACKGROUND: The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%-30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP. METHODS: We used a 16-year nationwide database to analyze the incidence of recurrent HSP. Patients with HSP were identified, and risk factors for recurrent HSP were explored. Kaplan-Meier and Cox regression model analyses were performed, and covariates were adjusted in the multivariate model...
April 16, 2018: Pediatric Rheumatology Online Journal
Wei Zheng, Linqian Zhang, Gao Long, Bo Chen, Xiaoli Shu, Mizu Jiang
BACKGROUND AND AIM: Systemic inflammatory response syndrome (SIRS) has to do with how the body reacts to injury. Herein, we analyzed the clinical features of acute pancreatitis (AP) in children with SIRS complication and investigated the role of SIRS score combined with C-reactive protein (CRP) level in assessing AP severity in children. METHODS: This retrospective cohort study involved 111 children hospitalized with AP at the Children's Hospital of Zhejiang University School of Medicine between January 2012 and August 2017...
April 12, 2018: Scandinavian Journal of Gastroenterology
Shu-Rong Wang, Yan Cheng, Min Chen, Ying-Xiu Zhang
OBJECTIVE: There are abundant data on secular trends in BMI; however, information on the change in subcutaneous fat is limited. The present study examined the trends in the prevalence of elevated skinfold thickness among children and adolescents over the past 19 years (1995-2014) in Shandong Province, China. DESIGN: Data for the study were obtained from two cross-sectional surveys of schoolchildren carried out in 1995 and 2014. Triceps and subscapular skinfold thicknesses (SFT) of all participants were measured...
April 4, 2018: Public Health Nutrition
Li-Jun Chen, Yu-Qi Zhang, Sheng-Fang Bao, Shu-Wen Zhong, Ai-Min Sun, Zhi-Fang Zhang
OBJECTIVE: Ventricular function assessment is very important for the treatment and prognostic classification of children with a single right ventricle (SRV) after cavopulmonary anastomosis (CPA). However, unusual ventricular shapes can result in inaccurate measurements. The aim of this study was to evaluate velocity vector imaging (VVI) for assessing segmental ventricular function in children with SRV after CPA. METHODS: Twenty-one children with SRV after CPA and 21 age- and sex-matched children with normal biventricular anatomy and function were included...
April 3, 2018: Current Medical Research and Opinion
Abdulkerim Eroglu, Kerry J Schulze, James Yager, Robert N Cole, Parul Christian, Bareng A S Nonyane, Sun Eun Lee, Lee Shu Fune Wu, Subarna Khatry, John Groopman, Keith P West
Carotenoids are naturally occurring pigments that function as vitamin A precursors, antioxidants, anti-inflammatory agents or biomarkers of recent vegetable and fruit intake, and are thus important for population health and nutritional assessment. An assay approach that measures proteins could be more technologically feasible than chromatography, thus enabling more frequent carotenoid status assessment. We explored associations between proteomic biomarkers and concentrations of 6 common dietary carotenoids (α-carotene, β-carotene, lutein/zeaxanthin, β-cryptoxanthin, and lycopene) in plasma from 500 6-8 year old Nepalese children...
March 29, 2018: Archives of Biochemistry and Biophysics
Michael P Citron, Manishkumar Patel, Mona Purcell, Shu-An Lin, Daniel J Rubins, Paul McQuade, Cheryl Callahan, Alexa Gleason, Ioan Petrescu, Walter Knapp, Chinedu Orekie, Sai Chamarthy, Zhiyun Wen, Sinoeun Touch, Matthew Pine, Jane Fontenot, Cameron Douglas, Xiaoping Liang, Amy S Espeseth
Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical candidates advance, cotton rats (Sigmodon hispidus) and non-human primates (NHP) continue to play a valuable role in RSV vaccine development, since both animals are semi-permissive to human RSV (HRSV). However, appropriate utilization of the models is critical to avoid mis-interpretation of the preclinical findings...
March 26, 2018: Vaccine
Charles R Greenwood, Alana G Schnitz, Dwight Irvin, Shu Fe Tsai, Judith J Carta
Purpose: The Language Environment Analysis (LENA®) represents a breakthrough in automatic speech detection because it makes one's language environment, what adults and children actually hear and say, efficiently measurable. The purpose of this article was to examine (a) current dimensions of LENA research, (b) LENA's sensitivity to differences in populations and language environments, and (c) what has been achieved in closing the Word Gap. Method: From electronic and human searches, 83 peer-reviewed articles using LENA were identified, and 53 met inclusionary criteria and were included in a systematic literature review...
March 28, 2018: American Journal of Speech-language Pathology
Shu Han You, Shu Li Wang, Wen Han Pan, Wan Ching Chan, Anna M Fan, Pinpin Lin
Fish and seafood consumption is a major source of human exposure to methylmercury (MeHg). This study evaluated the potential health risk of MeHg in Taiwanese children from fish and seafood consumption using a toxicokinetic model, hazard quotients and hazard indices (HIs). Two biomonitoring programs provided an important resource for blood specimens for assessing MeHg exposure in human populations. For internal exposures, total mercury (THg) was measured as a biomarker of MeHg in whole blood (WB) and red blood cells using inductively coupled plasma mass spectrometry and cold-vapor atomic absorption spectroscopy, respectively...
March 15, 2018: International Journal of Hygiene and Environmental Health
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