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https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-ldl-c-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#1
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes (T2DM) through mid-adulthood. Yet, there have been few studies examining whether early life-course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: We followed n = 7,725 children from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially impact the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28237296/frontal-subcortical-circuitry-in-social-attachment-and-relationships-a-cross-sectional-fmri-ale-meta-analysis
#2
Shu-Hui Lee, Zachary M Walker, James B Hale, S H Annabel Chen
Researchers have explored the concept of attachment in multiple ways, from animal studies examining imprinting to abnormal attachment in psychopathology. However, until recently, few have considered how neural circuitry develops the effective social bonds that are subsequently replicated in relationships across the lifespan. This current cross-sectional study undertook a fMRI Activation Likelihood Estimation (ALE) meta-analyses to examine the neurocircuitry that governs emotional and behavioural functions critical for building effective social relationships in children and adults...
February 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28236860/effect-of-equipotent-doses-of-bupivacaine-and-ropivacaine-in-high-fat-diet-fed-neonatal-rodent-model
#3
Ying-Dong Lian, Zong-Xiang Chen, Kang-Ru Zhu, Shu-Yin Sun, Li-Ping Zhu
OBJECTIVES: The increase in the prevalence of obesity presents a significant health and economic problem. Obesity has been reported to be a major contributor to variety of chronic diseases. Childhood obesity has been rising over the past decades leading to various complications in health. Millions of infants and children undergo surgery every year on various health grounds. The present investigation was undertaken to evaluate the effect of spinal anesthesia of equipotent doses of ropivacaine and bupivacaine on over-weight neonatal rats...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28235556/relation-of-polymorphism-of-arsenic-metabolism-genes-to-arsenic-methylation-capacity-and-developmental-delay-in-preschool-children-in-taiwan
#4
Ru-Lan Hsieh, Chien-Tien Su, Horng-Sheng Shiue, Wei-Jen Chen, Shiau-Rung Huang, Ying-Chin Lin, Ming-I Lin, Shu-Chi Mu, Ray-Jade Chen, Yu-Mei Hsueh
Inefficient arsenic methylation capacity has been associated with developmental delay in children. The present study was designed to explore whether polymorphisms and haplotypes of arsenic methyltransferase (AS3MT), glutathione-S-transferase omegas (GSTOs), and purine nucleoside phosphorylase (PNP) affect arsenic methylation capacity and developmental delay. A case-control study was conducted from August 2010 to March 2014. All participants were recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital...
February 21, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28213921/maternal-igf1-and-igf1r-polymorphisms-and-the-risk-of-spontaneous-preterm-birth
#5
Jian-Rong He, Yu-Mian Lai, Hui-Hui Liu, Guang-Jian Liu, Wei-Dong Li, Xue-Jiao Fan, Xue-Ling Wei, Xiao-Yan Xia, Ya-Shu Kuang, Xiao-Dan Liu, Nian-Nian Chen, Jin-Hua Lu, Qiao-Zhu Chen, Wei-Bi Mai, Hui-Min Xia, Xiu Qiu
BACKGROUND: The insulin-like growth factor (IGF) pathway was involved in the occurrence of spontaneous preterm birth (SPTB), but little is known regarding the relationship between genetic variations in IGF pathway and the risk of SPTB. We aimed to investigate the associations of IGF1 rs972936 and IGF1 receptor (IGF1R) rs2229765 polymorphisms with SPTB risk in a Chinese population. METHOD: A total of 114 cases of SPTB and 250 controls of term delivery were included from Guangzhou Women and Children's Medical Center, China...
February 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28202303/association-between-substance-use-diagnoses-and-psychiatric-disorders-in%C3%A2-an-adolescent-and-young-adult-clinic-based-population
#6
Justine Wittenauer Welsh, John R Knight, Sherry Shu-Yeu Hou, Monica Malowney, Patricia Schram, Lon Sherritt, J Wesley Boyd
PURPOSE: Adolescents with substance use disorders are more likely to have a current psychiatric disorder. However, when compared with the adult literature, there is relatively limited information regarding the specific co-occurrence of certain mental health diagnoses and substance use disorders in adolescents. The objectives of this study were to build on the previous literature regarding mental health diagnoses and different types of substance use disorders in adolescents, as well as explore the differences, if any, between groupings of mental health diagnosis and type of substance used...
February 12, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28202113/-effect-of-atopy-on-serum-glucocorticoid-receptor-levels-in-children-with-bronchiolitis
#7
Huan-Yin Yao, Wei-Rong Liu, Hang-Hu Zhang, Hua-Jun Li, Xiao-Xian Wang, Shu-Mei Liu, Xiao-Hong Chen
OBJECTIVE: To investigate the effect of atopy on the expression of glucocorticoid receptors in children with bronchiolitis. METHODS: ELISA was used to measure the changes in the serum levels of glucocorticoid receptor α (GRα) and glucocorticoid receptor β (GRβ) in the bronchiolitis group (77 children, including 34 children with atopy) and pneumonia group (68 children). Thirty-eight children who were prepared to undergo surgeries for non-infectious diseases and had no atopy or family history of allergic diseases were enrolled as the control group...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28173646/-clinical-characteristics-and-therapeutic-effect-of-drug-resistant-tuberculosis-in-children
#8
Q Liao, S Tan, Y Zhu, C M Wan, S Y Deng, M Shu
Objective: To explore the clinical characteristics of drug-resistant tuberculosis (TB) in children and to study the effectiveness of second-line anti-TB therapy for children and to examine the incidence of adverse drug reactions. Method: Retrospective research was conducted. The clinical records of children in West China Second Hospital diagnosed as drug-resistant TB from January 2010 to June 2014 were investigated.The clinical characteristics and risk factors were analyzed retrospectively. Treatment effect at discharge was examined as a short-term outcome indicator to evaluate the effectiveness of second-line anti-TB therapy and the incidence of adverse drug reactions...
February 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28171771/association-of-perfluoroalkyl-substances-exposure-with-impaired-lung-function-in-children
#9
Xiao-Di Qin, Zhengmin Min Qian, Shyamali C Dharmage, Jennifer Perret, Sarah Dee Geiger, Steven E Rigdon, Steven Howard, Xiao-Wen Zeng, Li-Wen Hu, Bo-Yi Yang, Yang Zhou, Meng Li, Shu-Li Xu, Wen-Wen Bao, Ya-Zhi Zhang, Ping Yuan, Jia Wang, Chuan Zhang, Yan-Peng Tian, Min Nian, Xiang Xiao, Wen Chen, Yungling Leo Lee, Guang-Hui Dong
Previous studies have demonstrated associations between serum levels of perfluoroalkyl substances (PFASs) and asthma or asthma related-biomarkers. However, no studies have reported a possible relationship between PFASs exposure and lung function among children. The objective of the present study is to test the association between PFASs exposure and lung function in children from a high exposure area by using a cross-sectional case-control study, which included 132 asthmatic children and 168 non-asthmatic controls recruited from 2009 to 2010 in the Genetic and Biomarkers study for Childhood Asthma...
February 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28168109/investigation-of-helicobacter-pylori-infection-among-symptomatic-children-in-hangzhou-from-2007-to-2014-a-retrospective-study-with-12-796-cases
#10
Xiaoli Shu, Mingfang Ping, Guofeng Yin, Mizu Jiang
BACKGROUND AND AIM: The infection of Helicobacter pylori (H. pylori) is acquired in childhood and the prevalence vary greatly in different countries and regions. The study aimed to investigate the characteristics of H. pylori infection among children with gastrointestinal symptoms in Hangzhou, a representative city of eastern China. METHODS: A systematic surveillance of H. pylori infection according to the (13)C-urea breath test was conducted from January 2007 to December 2014 in the Children's hospital, Zhejiang University School of Medicine...
2017: PeerJ
https://www.readbyqxmd.com/read/28151890/association-between-depression-and-enterovirus-infection-a-nationwide-population-based-cohort-study
#11
Yin-To Liao, Ming-Hong Hsieh, Yao-Hsu Yang, Ying-Ching Wang, Ching-Shu Tsai, Vincent Chin-Hung Chen, Michael Gossop
Enterovirus (EV) infection is common among children and adolescents. Few studies have investigated the relationship of depression after EV infection. This study explores an association between EV infection and subsequent depression in children and adolescents and assesses the risk of depression after EV infection with central nervous system involvement in a nationwide population-based retrospective cohort.A random sample of 1,000,000 people was derived from Taiwan National Health Insurance Research Database and we identified enrollees less than 18 years with EV infection before 2005 and followed up until December 2009...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28121929/correlation-of-symptomatic-enterovirus-infection-and-later-risk-of-allergic-diseases-via-a-population-based-cohort-study
#12
Zon-Min Lee, Ying-Hsien Huang, Shu-Chen Ho, Ho-Chang Kuo
Infants who are exposed to the rhinovirus or respiratory syncytial virus are at a higher risk of subsequently developing wheezing or asthma. This study aims to determine whether preschoolers with a history of symptomatic enterovirus infection are at an increased risk of developing allergic diseases or not.We used data from the Taiwan National Health Insurance Research Database from 1999 to 2006 for this nationwide population-based cohort study. The subsequent risks for allergic diseases, which included asthma (International Classification of Diseases [ICD]-9: 493...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28121917/clinical-features-of-benign-epilepsy-of-childhood-with-centrotemporal-spikes-in-chinese-children
#13
MULTICENTER STUDY
Meng-Jia Liu, Xiao-Jun Su, Xiu-Yu Shi Md, Ge-Fei Wu, Yu-Qin Zhang, Li Gao, Wei Wang, Jian-Xiang Liao, Hua Wang, Jian-Ning Mai, Jing-Yun Gao, Xiao-Mei Shu, Shao-Ping Huang, Li Zhang, Li-Ping Zou
This multicenter clinical trial was conducted to examine current practice of benign epilepsy with centrotemporal spikes and especially address the question that in what circumstances 1 antiepileptic drug (AED) should be preferred.Twenty-five medical centers participate in this clinical trial. The general information, clinical information, and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups was compared, and usefulness of the most commonly used AEDs was evaluated...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28121016/regression-equations-for-calculation-of-z-scores-for-echocardiographic-measurements-of-right-heart-structures-in-healthy-han-chinese-children
#14
Shan-Shan Wang, Yu-Qi Zhang, Shu-Bao Chen, Guo-Ying Huang, Hong-Yan Zhang, Zhi-Fang Zhang, Lan-Ping Wu, Wen-Jing Hong, Rong Shen, Yi-Qing Liu, Jun-Xue Zhu
OBJECTIVE: Clinical decision making in children with congenital and acquired heart disease relies on measurements of cardiac structures using two-dimensional echocardiography. We aimed to establish z-score regression equations for right heart structures in healthy Chinese Han children. METHODS: Two-dimensional and M-mode echocardiography was performed in 515 patients. We measured the dimensions of the pulmonary valve annulus (PVA), main pulmonary artery (MPA), left pulmonary artery (LPA), right pulmonary artery (RPA), right ventricular outflow tract at end-diastole (RVOTd) and at end-systole (RVOTs), tricuspid valve annulus (TVA), right ventricular inflow tract at end-diastole (RVIDd) and at end-systole (RVIDs), and right atrium (RA)...
January 25, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28114728/the-modified-respiratory-index-score-ris-guides-resource-allocation-in-acute-bronchiolitis
#15
Shu-Ling Chong, Oon Hoe Teoh, Nivedita Nadkarni, Joo Guan Yeo, Zaw Lwin, Yong-Kwang Gene Ong, Jan Hau Lee
BACKGROUND AND OBJECTIVE: Bronchiolitis is a common disease in early childhood with increasing healthcare utilization. We aim to study how well a simple and improved respiratory score (the modified Respiratory Index Score [RIS]) would perform when predicting for a warranted admission. METHODS: This is an observational prospective study, from June 2015 to December 2015 in a paediatric emergency department (ED) of a large tertiary hospital in Singapore. We included children aged less than 2 years old, presenting with typical symptoms and signs of bronchiolitis but excluded children with four or more previous wheezes, a gestation of <35 weeks, and known cardiopulmonary disease...
January 23, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28110260/road-traffic-injuries-among-children-and-adolescents-in-singapore-who-is-at-greatest-risk
#16
Shu-Ling Chong, Arif Tyebally, Su Yah Chew, Yang Chern Lim, Xun Yi Feng, Sock Teng Chin, Lois K Lee
INTRODUCTION: Pediatric road traffic injuries remain a significant cause of death and disability in many countries in Asia, despite the implementation of road traffic safety laws. We aim to describe the injuries, the use of restraints among road users, and risk factors associated with severe injuries for children in Singapore. METHODS: We performed a retrospective chart review of road traffic injuries presenting to the only two pediatric tertiary care hospitals in Singapore, from January 2012 to April 2016...
March 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28101236/identification-of-proteins-associated-with-pediatric-bilateral-wilms-tumor
#17
Zechen Yan, Qingjun Meng, Jinjian Yang, Junjie Zhang, Wei Zhao, Fei Guo, Dongjian Song, Yuxiao Zhan, Dandan Fan, Ruiyi Zhou, Shuqiang Zuo, Zehua Wang, Jiekai Yu, Shu Zheng, Jiaxiang Wang
Wilms tumor (WT) is the most common cancer that primarily develops in abdominal solid organ of children. It has no incipient symptom, and the most frequent symptoms are a painless, palpable abdominal mass. Proteomics technology was used to select the differentially expressed proteins of bilateral Wilms tumor (BWT). Ten serum samples of children with BWT were chosen, 20 serum samples of children with unilateral WT (UWT) and 20 serum samples of healthy children were selected, and proteomics technology was used to detect and collect data...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100318/-clinical-characteristics-of-clonal-evolution-after-immunosuppressive-therapy-in-children-with-severe-very-severe-aplastic-anemia
#18
Jing-Liao Zhang, Tian-Feng Liu, Li-Xian Chang, Xia Chen, Yuan-Yuan Ren, Cong-Cong Sun, Chao Liu, Wen-Bin An, Yang Wan, Xiao-Juan Chen, Wen-Yu Yang, Shu-Chun Wang, Ye Guo, Yao Zou, Yu-Mei Chen, Xiao-Fan Zhu
OBJECTIVE: To evaluate the clinical characteristics and risk factors of clonal evolution after immunosuppressive therapy (IST) in children with severe/very severe aplastic anemia (SAA/VSAA). METHODS: The clinical data of 231 children with newly-diagnosed SAA/VSAA who received IST were retrospectively studied. The incidence and risk factors of clonal evolution after IST were analyzed. RESULTS: The 5-year overall survival rate of the 231 patients was 82...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099871/fluoride-and-arsenic-exposure-affects-spatial-memory-and-activates-the-erk-creb-signaling-pathway-in-offspring-rats
#19
Yu-Peng Zhu, Shu-Hua Xi, Ming-Yan Li, Ting-Ting Ding, Nan Liu, Fu-Yuan Cao, Yang Zeng, Xiao-Jing Liu, Jun-Wang Tong, Shou-Fang Jiang
Fluoride and arsenic are inorganic contaminants that occur in the natural environment. Chronic fluoride and/or arsenic exposure can induce developmental neurotoxicity and negatively influence intelligence in children, although the underlying molecular mechanisms are poorly understood. This study explored the effects of fluoride and arsenic exposure in drinking water on spatial learning, memory and key protein expression in the ERK/CREB signaling pathway in hippocampal and cerebral cortex tissue in rat offspring...
January 15, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28092910/effects-of-in-utero-and-postnatal-exposure-to-secondhand-smoke-on-lung-function-by-gender-and-asthma-status-the-seven-northeastern-cities-snec-study
#20
Li-Wen Hu, Mo Yang, Shu Chen, Kuntal Shah, Yismaw Hailegiorgis, Richai Burgens, Michael Vaughn, Jin Huang, Pamela Xaverius, Gunther Paul, Lidia Morawska, Tao Lu, Shao Lin, Shou-Qiang Zhong, Min-Li Kong, Yan-Qi Xie, Yuan-Tao Hao, Xiao-Wen Zeng, Zhengmin Qian, Guang-Hui Dong
BACKGROUND: Little information exists on whether gender or asthma status modifies the effects of secondhand smoke (SHS) exposure on lung function. OBJECTIVE: To evaluate whether gender or asthma status modifies the association of SHS exposure with lung function. METHODS: A total of 6,740 children (average 11.6 years) were recruited from 24 districts of 7 cities in northeast China in 2012. SHS exposure included exposure to environmental and maternal smoking both in utero and during early childhood (postnatal)...
2017: Respiration; International Review of Thoracic Diseases
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