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https://www.readbyqxmd.com/read/27893696/molecular-epidemiological-study-of-enteroviruses-associated-with-encephalitis-in-children-from-hangzhou-china
#1
Wei Li, Zhang Qiong, Shen Xiao-Ting, Liu Yu-Jie, Mao Jian-Hua, Shu Qiang, Shang Shi-Qiang
Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889737/immune-thrombocytopenic-purpura-in-children-of-eastern-henan-province-china
#2
Qiu-Xia Fan, Chun-Mei Wang, Shu-Xia Chen, Xin-Guang Liu, Bo Han
In this retrospective cohort study conducted in 63 children with idiopathic thrombocytopenic purpura (ITP) in China; petechiae, bruises and bleeding were the major presentations. Most cases required therapy with one/more treatment options.
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27887573/in-vitro-function-of-upstream-visfatin-polymorphisms-that-are-associated-with-adverse-cardiometabolic-parameters-in-obese-children
#3
Delicia Shu Qin Ooi, Siong Gim Ong, Chew Kiat Heng, Kah Yin Loke, Yung Seng Lee
BACKGROUND: Visfatin is an adipokine associated with glucose and lipid metabolism. We previously reported two visfatin upstream single nucleotide polymorphisms (SNPs), c.-3187G > A (rs11977021) and c.-1537C > T (rs61330082), which were in perfect linkage disequilibrium, in a Singaporean cohort of severely obese children and are associated with visfatin level and adverse cardiometabolic parameters. We aim to functionally characterize the effect of c.-3187G > A and c...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27883911/examining-the-relationship-between-rapid-automatized-naming-and-arithmetic-fluency-in-chinese-kindergarten-children
#4
Jiaxin Cui, George K Georgiou, Yiyun Zhang, Yixun Li, Hua Shu, Xinlin Zhou
Rapid automatized naming (RAN) has been found to predict mathematics. However, the nature of their relationship remains unclear. Thus, the purpose of this study was twofold: (a) to examine how RAN (numeric and non-numeric) predicts a subdomain of mathematics (arithmetic fluency) and (b) to examine what processing skills may account for the RAN-arithmetic fluency relationship. A total of 160 third-year kindergarten Chinese children (83 boys and 77 girls, mean age=5.11years) were assessed on RAN (colors, objects, digits, and dice), nonverbal IQ, visual-verbal paired associate learning, phonological awareness, short-term memory, speed of processing, approximate number system acuity, and arithmetic fluency (addition and subtraction)...
November 21, 2016: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/27877087/il28b-snp-rs12979860-is-the-critical-predictor-for-sustained-viral-response-in-chinese-children-aged-1-to-6-years-with-chronic-hepatitis-c
#5
Yan-Wei Zhong, Hong-Fei Zhang, Yan-Min Shi, Yong-Li Li, Fang Chu, Zhi-Qiang Xu, Da-Wei Chen, Yu Gan, Fu-Chuan Wang, Mei-Lei Gu, Yi Dong, Shi-Shu Zhu, Ce Shi, Hua-Hao Fan, Xiu-Chang Zhang, Min Zhang
Clinical data on children with chronic hepatitis C (CHC) remain extremely limited. This study investigated sustained virologic response (SVR) to alfa-interferon 2b plus RBV treatment in children aged 1-6 years with unsafe injection-acquired CHC. 154 children with CHC aged 1 to 6 years were enrolled, 101 of them were male (65.6%) and 53 were female (34.4%), and they were treated with alfa-interferon at a dose of 1-5 MIU/m(2) 3 times weekly plus oral RBV (15 mg/kg/day) for 48 weeks. 57(39.3 %) of them were genotype 1b, 73(50...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27853979/erratum-to-clinical-and-molecular-features-of-38-children-with-chronic-granulomatous-disease-in-mainland-china
#6
Huan Xu, Wen Tian, Shu-Juan Li, Lu-Ying Zhang, Wei Liu, Yao Zhao, Zhi-Yong Zhang, Xue-Mei Tang, Mo Wang, Dao-Qi Wu, Ji-Sheng Shi, Yuan Ding, Xiao-Dong Zhao, Xi-Qiang Yang, Li-Ping Jiang
No abstract text is available yet for this article.
November 16, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27853293/association-of-arsenic-methylation-capacity-with-developmental-delays-and-health-status-in-children-a-prospective-case-control-trial
#7
Yu-Mei Hsueh, Wei-Jen Chen, Chih-Ying Lee, Ssu-Ning Chien, Horng-Sheng Shiue, Shiau-Rung Huang, Ming-I Lin, Shu-Chi Mu, Ru-Lan Hsieh
This case-control study identified the association between the arsenic methylation capacity and developmental delays and explored the association of this capacity with the health status of children. We recruited 120 children with developmental delays and 120 age- and sex-matched children without developmental delays. The health status of the children was assessed using the Pediatric Quality of Life Inventory (PedsQL) and Pediatric Outcomes Data Collection Instrument (PODCI). The arsenic methylation capacity was determined by the percentages of inorganic arsenic (InAs%), monomethylarsonic acid (MMA(V)%), and dimethylarsinic acid (DMA(V)%) through liquid chromatography and hydride generation atomic absorption spectrometry...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852413/-clinical-analysis-of-acute-disseminated-encephalomyelitis-in-44-cases
#8
X N Zhong, B J Zhang, Y G Wang, Y L Huang, Y Q Shu, Z Z Lu, X Q Hu, W Qiu
Objective: To investigate the clinical features in 44 patients with acute disseminated encephalomyelitis (ADEM). Methods: Consecutive ADEM patients admitted to Neurology Department of the Third Affiliated Hospital of Sun yat-sen University during August 2009 to July 2014 were enrolled.Clinical and laboratory data of the patients were reviewed and analyzed. Results: Forty-four patients with ADEM based on the 2012 criteria were recruited, including 23 male and 21 female; 9 children, 11 teenagers and 24 adults...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27851998/clinical-and-molecular-features-of-adenovirus-type-2-3-and-7-infections-in-children-in-an-outbreak-in-taiwan-2011
#9
Ming-Ru Lin, Shu-Li Yang, Yu-Nong Gong, Ching-Chia Kuo, Cheng-Hsun Chiu, Chih-Jung Chen, Yu-Chia Hsieh, Chen-Yen Kuo, Chun-Wan Fang, Kuo-Chien Tsao, Yhu-Chering Huang
OBJECTIVES: We studied pediatric patients with human adenovirus (HAdV) infection during the 2011 outbreak in northern Taiwan in order to define the clinical features of different HAdV genotypes in children. METHODS: Between January and December 2011, 637 patients <19 years of age exhibited culture-confirmed adenoviral infection in Chang Gung Memorial Hospital, and provided specimens available for genotyping by multiplex real-time polymerase chain reaction. Clinical data were retrospectively collected...
November 13, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27830016/effects-of-leukotriene-d4-on-adenoidal-t-cells-in-children-with-obstructive-sleep-apnea-syndrome
#10
Yan Shu, Da-Zhi Yang, Jia Liang, Feng Zhang, Bing Wang, Hong-Bing Yao, En-Mei Liu
PURPOSE: This study aims to determine whether leukotriene D4 (LTD4) can promote T cell proliferation in adenoid tissues via activation of CysLT1 receptors in children with OSAS. METHODS: CD4(+) and CD8(+) T cell proliferation was assessed by flow cytometry in adenoid mononuclear cells (AdMCs) stimulated with LTD4 from children with OSAS. The activation of mitogen-activated protein kinase pathways and their effects on the proliferation of CD4(+) and CD8(+) T cells in AdMCs were observed by western blotting...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27823995/analysis-of-in-hospital-neonatal-death-in-the-tertiary-neonatal-intensive-care-unit-in-china-a-multicenter-retrospective-study
#11
Chen-Hong Wang, Li-Zhong Du, Xiao-Lu Ma, Li-Ping Shi, Xiao-Mei Tong, Hong Liu, Guo-Fang Ding, Bin Yi, Xin-Nian Pan, Dan-Ni Zhong, Ling Liu, Mei Li, Cui-Qing Liu, Shi-Wen Xia, Hong-Yun Wang, Ling He, Kun Liang, Xiao-Yu Zhou, Shu-Ping Han, Qin Lyu, Yin-Ping Qiu, Ruo-Bing Shan, De-Zhi Mu, Xiao-Hong Liu, Si-Qi Zhuang, Jing Guo, Li Liu, Jia-Jun Zhu, Hong Xiong
BACKGROUND: Globally, the proportion of child deaths that occur in the neonatal period remains a high level of 37-41%. Differences of cause in neonate death exist in different regions as well as in different economic development countries. The specific aim of this study was to investigate the causes, characteristics, and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit (NICU) of China. METHODS: All the dead neonates admitted to 26 NICUs were included between January l, 2011, and December 31, 2011...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27821281/molecular-determinants-of-sulfadoxine-pyrimethamine-resistance-in-plasmodium-falciparum-in-nigeria-and-the-regional-emergence-of-dhps-431v
#12
Mary C Oguike, Catherine O Falade, Elvis Shu, Izehiuwa G Enato, Ismaila Watila, Ebenezer S Baba, Jane Bruce, Jayne Webster, Prudence Hamade, Sylvia Meek, Daniel Chandramohan, Colin J Sutherland, David Warhurst, Cally Roper
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes in P. falciparum populations in Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections imported to the United Kingdom from Nigeria. To assess how widespread this mutation is among parasites in different parts of the country and consequently fill the gap in sulfadoxine-pyrimethamine (SP) resistance data in Nigeria, we retrospectively analysed 1000 filter paper blood spots collected in surveys of pregnant women and children with uncomplicated falciparum malaria between 2003 and 2015 from four sites in the south and north...
September 29, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27816501/gapdh-mediated-posttranscriptional-regulations-of-sodium-channel-scn1a-and-scn3a-genes-under-seizure-and-ketogenic-diet-conditions
#13
Guo-Wang Lin, Ping Lu, Tao Zeng, Hui-Ling Tang, Yong-Hong Chen, Shu-Jing Liu, Mei-Mei Gao, Qi-Hua Zhao, Yong-Hong Yi, Yue-Sheng Long
Abnormal expressions of sodium channel SCN1A and SCN3A genes alter neural excitability that are believed to contribute to the pathogenesis of epilepsy, a long-term risk of recurrent seizures. Ketogenic diet (KD), a high-fat and low-carbohydrate treatment for difficult-to-control (refractory) epilepsy in children, has been suggested to reverse gene expression patterns. Here, we reveal a novel role of GAPDH on the posttranscriptional regulation of mouse Scn1a and Scn3a expressions under seizure and KD conditions...
November 2, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27810664/the-resilience-status-of-empty-nest-elderly-in-a-community-a-latent-class-analysis
#14
Jie Zhang, Jing-Ping Zhang, Qiao-Mei Cheng, Fei-Fei Huang, Shu-Wen Li, An-Ni Wang, Pan Su
OBJECTIVE: The aim of this study was to examine the status and characteristics of resilience among empty-nest elderly in a community in China using exploratory latent class analysis (LCA). METHODS: This study enrolled 250 empty-nest elderly as the study respondents. General information regarding the resilience of empty-nest elderly was investigated using the General Information Questionnaire and Connor-Davidson Resilience Scale, Chinese version, and we then used LCA and multivariate logistic regression to discuss the characteristics of resilience among empty-nest elderly individuals...
January 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27806793/-extracorporeal-membrane-oxygenation-for-rescuing-12-children-with-acute-fulminant-myocarditis
#15
L F Ye, Y Fan, C M Zhang, Q Shu, L Z Du, R Lin
Objective: To summarize clinical experience of using extracorporeal membrane oxygenation (ECMO) in rescuing children with acute fulminant myocarditis (AFM). Method: Data of 12 children with acute fulminate myocarditis (6 boys and 6 girls, median age 8.3 (0.6, 13.0) years, median weight 33.1 (6, 61) kg) who were rescued with ECMO in Children's Hospital, Zhejiang University from September 2009 to August 2015 were analyzed retrospectively. The analysis focused on the intervene timing of ECMO for the cardiogenic shock and hypoperfusion caused by heart failure and(or) lethal arrhythmia and the essentials of ECMO cardiopulmonary resuscitation(ECPR) for cardiac arrest in pediatric AFM were summarized...
November 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27798013/safety-and-immunogenicity-of-a-new-13-valent-pneumococcal-conjugate-vaccine-versus-a-licensed-7-valent-pneumococcal-conjugate-vaccine-a-study-protocol-of-a-randomised-non-inferiority-trial-in-china
#16
Jing Jing Chen, Lin Yuan, Zhen Huang, Nian Min Shi, Yu Liang Zhao, Sheng Li Xia, Guo Hua Li, Rong Cheng Li, Yan Ping Li, Shu Yuan Yang, Jie Lai Xia
INTRODUCTION: The invasive pneumococcal diseases (IPDs) caused by Streptococcus pneumoniae pose an enormous threat to children under 5 years of age. However, routine use of pneumococcal conjugate vaccines could aid in reducing the incidence of IPDs. The purpose of this clinical trial is to assess the non-inferiority of the investigational 13-valent pneumococcal conjugate vaccine (PCV13) to the currently licensed 7-valent pneumococcal conjugate vaccine (PCV7). METHODS AND ANALYSIS: 1040 infants will receive a three-dose series of either PCV13 or PCV7 at ages 3, 4 and 5 months, respectively, and a booster dose at 12-15 months...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27788023/argon-plasma-coagulation-combined-with-a-flexible-electronic-bronchoscope-for-treating-foreign-body-granulation-tissues-in-children-s-deep-bronchi-nine-case-reports
#17
Linhua Shu, Yijing Hu, Rong Wei
Deep bronchial obstruction in children caused by foreign bodies is a medical emergency frequently accompanied by the formation of granulation tissue in the airway mucosa, which is resected during removal of the foreign body. Argon plasma coagulation (APC), initially developed to achieve hemostasis in gastrointestinal bleeding during endoscopic procedures, is also used for interventional bronchoscopic therapies of malignant airway tumors. In this pilot study, we describe successful alternative resections of granulation tissues during foreign body removal by flexible bronchoscopy through concomitant APC applications in 9 children aged from 16 months to 4 years old...
October 27, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27785028/screening-for-attention-deficit-and-hyperactivity-disorder-autism-spectrum-disorder-and-developmental-delay-in-taiwanese-aboriginal-preschool-children
#18
Hsiang-Lin Chan, Wen-Sheng Liu, Yi-Hsuan Hsieh, Chiao-Fan Lin, Tiing-Soon Ling, Yu-Shu Huang
OBJECTIVES: This study aimed to estimate the percentages of attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in Taiwanese aboriginal preschool children. Child development level was compared between the two groups. METHODS: Teachers completed screening questionnaires for ADHD, ASD, and development level for 36- to 72-month-old children in kindergartens in Taiwan. The questionnaire results were compared between the aboriginal and nonaboriginal children...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27781392/increasing-observation-rates-in-low-risk-pediatric-immune-thrombocytopenia-using-a-standardized-clinical-assessment-and-management-plan-scamp-%C3%A2
#19
Michelle L Schoettler, Dionne Graham, Wen Tao, Margaret Stack, Elaine Shu, Lauren Kerr, Ellis J Neufeld, Rachael F Grace
An observational approach is recommended in newly diagnosed children with immune thrombocytopenia (ITP) at low risk of bleeding; however, there is no standard definition of risk. A standardized clinical assessment and management plan (SCAMP(®) ), a modifiable practice guideline, was implemented and revised (SCAMP-1 and SCAMP-2) and applied to 71 newly diagnosed patients with ITP. The Buchanan and Adix bleeding score guided treatment and was modified by stratifying by low- and high-risk grade 3 bleeding in SCAMP-2...
October 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27777202/-serum-non-esterified-fatty-acids-to-albumin-ratio-increased-significantly-in-children-with-nephrotic-syndrome
#20
Chun-Li Fan, Jia Wu, Xiao-Min Bu, Shu-Jun Wan, Peng-Tao Guo, Yan-Juan Ma, Jun-Jun Wang
OBJECTIVE: To analyze serum levels of non-esterified fatty acids (NEFA) and albumin (ALB) in children with nephrotic syndrome (NS) and investigate the clinical significance of altered serum NEFA to ALB ratio in children with NS in acute and remission phases. METHODS: Serum levels of NEFA and ALB were measured in 55 NS children in acute phase, in 33 NS children in remission and in 122 healthy control children, and the ratio of NEFA to ALB was calculated. The other lipid/lipoprotein and renal function parameters were also analyzed in these children...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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