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Tenofovir in childrens

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https://www.readbyqxmd.com/read/27898591/tenofovir-exposure-in-utero-and-linear-growth-in-hiv-exposed-uninfected-infants
#1
Stanzi M le Roux, Jennifer Jao, Kirsty Brittain, Tamsin K Phillips, Seun Olatunbosun, Agnes Ronan, Allison Zerbe, Elaine J Abrams, Landon Myer
OBJECTIVE: Tenofovir (TDF) affects bone health and is widely used in pregnancy but data are limited on the effects of TDF exposure in utero. We examined the association between duration of in-utero TDF exposure and linear growth in HIV-exposed, uninfected (HEU) infants. DESIGN: A prospective cohort of pregnant women initiating TDF-containing regimens at primary care services in Cape Town, South Africa, were enrolled and followed with their breastfeeding infants through 12 months postpartum...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27879486/prospective-interventional-study-of-tenofovir-in-pregnancy-to-prevent-vertical-transmission-of-hepatitis-b-in-highly-viremic-women
#2
Pierre O Sellier, Sarah Maylin, Béatrice Berçot, Dorothée Chopin, Amanda Lopes, Guy Simoneau, John Evans, Véronique Delcey, Jean-Louis Bénifla, François Simon, Jean-François Bergmann
BACKGROUND: The risk of vertical transmission of hepatitis B virus (HBV) increases as maternal HBV DNA increase, despite serovaccination to newborns. METHODS: From 1 July 2012 to 1 January 2016, all pregnant women in Lariboisiere Hospital, Paris, France, with HBV DNA of 5 log10 IU/ml and above were administered tenofovir from week 28 of pregnancy until delivery. HBV DNA was measured at months 1, 2 of tenofovir and at delivery. The newborns were serovaccinated, tested for hepatitis B surface antigen, hepatitis B core antibody (HBcAb)±HBV DNA, and hepatitis B surface antibody (HBsAb) when aged 9 months, and then 24 months...
November 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27798548/growth-at-two-years-of-age-in-hiv-exposed-uninfected-children-in-the-us-by-trimester-of-maternal-antiretroviral-initiation
#3
Denise L Jacobson, Kunjal Patel, Paige L Williams, Mitchell E Geffner, George K Siberry, Linda A Dimeglio, Marilyn J Crain, Ayesha Mirza, Janet S Chen, Elizabeth McFarland, Deborah Kacanek, Margarita Silio, Kenneth Rich, William Borkowsky, Russell B Van Dyke, Tracie L Miller
BACKGROUND: Abnormal childhood growth may affect future health. Maternal tenofovir (TFV) use was associated with lower body length and head circumference at one year of age in HIV-exposed uninfected (HEU) US children. METHODS: We studied 509 HEU children in the US-based Surveillance Monitoring of ART Toxicities cohort whose HIV-infected mothers were not using antiretrovirals at the last menstrual period and began combination antiretroviral therapy (cART) in pregnancy (cART-initiators)...
October 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27765666/safety-efficacy-and-pharmacokinetics-of-a-single-tablet-regimen-containing-elvitegravir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-treatment-naive-hiv-infected-adolescents-a-single-arm-open-label-trial
#4
Aditya H Gaur, Hilda Kizito, Wasana Prasitsueubsai, Natella Rakhmanina, Mohammed Rassool, Rana Chakraborty, Jagmohan Batra, Pope Kosalaraksa, Wicharn Luesomboon, Danielle Porter, Yongwu Shao, Michael Myers, Lillian Ting, Devi SenGupta, Erin Quirk, Martin S Rhee
BACKGROUND: The prodrug tenofovir alafenamide is associated with improved renal and bone safety compared with tenofovir disoproxil fumarate. We aimed to assess safety, pharmacokinetics, and efficacy of this single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-infected, treatment-naive adolescents. METHODS: We did a 48 week, single-arm, open-label trial in treatment-naive adolescents with HIV from ten hospital clinics in South Africa, Thailand, Uganda, and the USA...
December 2016: Lancet HIV
https://www.readbyqxmd.com/read/27755111/tenofovir-exposure-in-utero-and-linear-growth-in-hiv-exposed-uninfected-infants-a-prospective-study
#5
Stanzi M le Roux, Jennifer Jao, Kirsty Brittain, Tamsin K Phillips, Seun Olatunbosun, Agnes Ronan, Allison Zerbe, Elaine J Abrams, Landon Myer
OBJECTIVE: Tenofovir (TDF) affects bone health and is widely used in pregnancy but data are limited on the effects of TDF exposure in utero. We examined the association between duration of in utero TDF exposure and linear growth in HIV-exposed, uninfected (HEU) infants. DESIGN: A prospective cohort of pregnant women initiating TDF-containing regimens at primary care services in Cape Town, South Africa were enrolled and followed with their breastfeeding infants through 12 months postpartum...
October 14, 2016: AIDS
https://www.readbyqxmd.com/read/27699054/opsoclonus-myoclonus-ataxia-syndrome-in-an-hiv-infected-child
#6
Noella Maria Delia Pereira, Ira Shah, Shilpa Kulkarni
Opsoclonus-myoclonus-ataxia (OMA) syndrome typically presents with chaotic eye movements and myoclonus with some patients exhibiting ataxia and behavioural disturbances. The pathogenesis may be inflammatory with an infectious or paraneoplastic trigger. We present a 13-year-old HIV-infected girl who was initially started on highly active antiretroviral therapy (HAART) in March 2013 with a CD4 count of 79 cells/cumm. Initially, the patient did not comply with treatment, resulting in a CD4+ count of 77 cells/mm(3) in November 2015 and prompting a new HAART scheme comprising lamivudine, tenofovir and ritonavir-boosted atazanavir...
October 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/27676257/pre-exposure-prophylaxis-use-by-breastfeeding-hiv-uninfected-women-a-prospective-short-term-study-of-antiretroviral-excretion-in-breast-milk-and-infant-absorption
#7
Kenneth K Mugwanya, Craig W Hendrix, Nelly R Mugo, Mark Marzinke, Elly T Katabira, Kenneth Ngure, Nulu B Semiyaga, Grace John-Stewart, Timothy R Muwonge, Gabriel Muthuri, Andy Stergachis, Connie L Celum, Jared M Baeten
BACKGROUND: As pre-exposure prophylaxis (PrEP) becomes more widely used in heterosexual populations, an important consideration is its safety in infants who are breastfed by women taking PrEP. We investigated whether tenofovir and emtricitabine are excreted into breast milk and then absorbed by the breastfeeding infant in clinically significant concentrations when used as PrEP by lactating women. METHODS AND FINDINGS: We conducted a prospective short-term, open-label study of daily oral emtricitabine-tenofovir disoproxil fumarate PrEP among 50 HIV-uninfected breastfeeding African mother-infant pairs between 1-24 wk postpartum (ClinicalTrials...
September 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27547761/virological-and-immunological-status-of-the-people-living-with-hiv-aids-undergoing-art-treatment-in-nepal
#8
Chet Raj Ojha, Geeta Shakya, Shyam Prakash Dumre
Antiretroviral therapy (ART) has increased the life span of the people living with HIV (PLHIV), but their virological and immunological outcomes are not well documented in Nepal. The study was conducted at a tertiary care center including 826 HIV-1 seropositive individuals undergoing ART for at least six months. Plasma viral load (HIV-1 RNA) was detected by Real Time PCR and CD4(+) T-lymphocyte (CD4(+)) counts were estimated by flow cytometry. The mean CD4(+) count of patients was 501 (95% CI = 325-579) cells/cumm, but about 35% of patients had CD4(+) T cell counts below 350 cells/cumm...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27494909/levels-of-bone-markers-in-a-population-of-infants-exposed-in-utero-and-during-breastfeeding-to-tenofovir-within-an-option-b-programme-in-malawi
#9
Marco Floridia, Giuseppe Liotta, Mauro Andreotti, Clementina M Galluzzo, Roberta Amici, Haswell Jere, Jean-Baptiste Sagno, Maria C Marazzi, Ersilia Buonomo, Paola Scarcella, Sandro Mancinelli, Stefano Vella, Marina Giuliano, Leonardo Palombi
OBJECTIVES: No data are available on bone metabolism in infants exposed to tenofovir during breastfeeding. We investigated bone metabolism markers in the first year of life in infants from mothers who received tenofovir, lamivudine and efavirenz during pregnancy and 12 months of breastfeeding in a national Option B+ programme in Malawi. METHODS: Serum samples collected at 6 and 12 months in tenofovir-exposed infants and in a small sample of tenofovir-unexposed infants from the same clinical centre were analysed in batches for levels of bone-specific alkaline phosphatase (BAP; marker of bone formation) and of C-terminal telopeptide of type I collagen (CTX; marker of bone resorption)...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27355415/treatment-outcomes-and-resistance-patterns-of-children-and-adolescents-on-second-line-antiretroviral-therapy-in-asia
#10
Wasana Prasitsuebsai, Sirinya Teeraananchai, Thida Singtoroj, Khanh Huu Truong, Jintanat Ananworanich, Viet Chau Do, Lam Van Nguyen, Pope Kosalaraksa, Nia Kurniati, Tavitiya Sudjaritruk, Kulkanya Chokephaibulkit, Stephen J Kerr, Annette H Sohn
BACKGROUND: Data on pediatric treatment outcomes and drug resistance while on second-line antiretroviral therapy (ART) are needed to guide HIV care in resource-limited countries. METHODS: HIV-infected children <18 years who were switched or switching to second-line ART after first-line failure were enrolled from 8 sites in Indonesia, Thailand, and Vietnam. Genotyping was performed at virologic failure (VF; HIV-RNA >1000 copies/mL). Cox proportional hazards regression was used to evaluate factors predicting VF...
August 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27310962/off-label-use-of-rilpivirine-in-combination-with-emtricitabine-and-tenofovir-in-hiv-1-infected-pediatric-patients-a-multicenter-study
#11
Lola Falcon-Neyra, Claudia Palladino, María Luisa Navarro Gómez, Pere Soler-Palacín, María Isabel González-Tomé, Santiago J De Ory, Marie Antoinette Frick, Clàudia Fortuny, Antoni Noguera-Julian, Elena Bermúdez Moreno, Juan Luis Santos, Peter Olbrich, Luis F López-Cortés, Verónica Briz, Olaf Neth
To assess the safety and efficacy of rilpivirine in combination with emtricitabine and tenofovir (RPV/FTC/TDF) as a once-daily single-tablet regimen (STR) in HIV-1-infected children and adolescents we performed a multicenter case series study of HIV-1-infected patients. Inclusion criteria were initiation of therapy with RPV/FTC/TDF before the age of 18. Patients were divided into undetectable viral load (uVL) group, HIV-1 RNA < 20 copies/mL on stable combined antiretroviral therapy (cART), and detectable viral load (dVL) group, HIV-1 RNA ≥ 20 copies/mL at RPV/FTC/TDF initiation...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27242802/the-phacs-smartt-study-assessment-of-the-safety-of-in-utero-exposure-to-antiretroviral-drugs
#12
REVIEW
Russell B Van Dyke, Ellen Gould Chadwick, Rohan Hazra, Paige L Williams, George R Seage
The Surveillance Monitoring for ART Toxicities (SMARTT) cohort of the Pediatric HIV/AIDS Cohort Study includes over 3,500 HIV-exposed but uninfected infants and children at 22 sites in the US, including Puerto Rico. The goal of the study is to determine the safety of in utero exposure to antiretrovirals (ARVs) and to estimate the incidence of adverse events. Domains being assessed include metabolic, growth and development, cardiac, neurological, neurodevelopmental (ND), behavior, language, and hearing. SMARTT employs an innovative trigger-based design as an efficient means to identify and evaluate adverse events...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26895340/erratum-to-renal-and-bone-adverse-effects-of-a-tenofovir-based-regimen-in-the-treatment-of-hiv-infected-children-a-systematic-review
#13
Rose I Okonkwo, Anita E Weidmann, Emmanuel E Effa
No abstract text is available yet for this article.
April 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/26890208/bone-health-in-hiv-infected-children-and-adolescents
#14
Allison R Eckard, Stefano Mora
PURPOSE OF REVIEW: Chronic HIV infection and exposure to antiretroviral therapy compromises bone health in children and adolescents, potentially impacting their long-term quality of life. Thus, the purpose of this article is to review the most recent literature on this topic in HIV-infected children and adolescents. RECENT FINDINGS: Recent studies continue to demonstrate bone abnormalities in HIV-infected children and adolescents, whether HIV is acquired perinatally or during adolescence...
May 2016: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/26709883/short-article-hepatitis-b-virus-status-in-children-born-to-hiv-hbv-coinfected-women-in-a-french-hospital-a-cross-sectional-study
#15
Pierre O Sellier, Nathalie Schnepf, Rishma Amarsy, Sarah Maylin, Amanda Lopes, Marie-Christine Mazeron, Clara Flateau, Marjolaine Morgand, Nicole Ciraru-Vigneron, Aurore Berthe, Guy Simoneau, John Evans, Safia Souak, Sophie Matheron, Jean-Louis Benifla, François Simon, Jean-François Bergmann
OBJECTIVES: We assessed hepatitis B virus (HBV) status in children born to HIV/HBV coinfected women with large access to antiretroviral therapy. METHODS: All HIV/HBV coinfected pregnant women from 01 January 2000 to 01 January 2012 were included in the retrospective study (NCT02044068). Antiretroviral therapy during pregnancy and injection of HBV immunoglobulin/vaccine to newborns was recorded. We assessed HBV status of children aged at least 2 years. RESULTS: Twenty-one women (35 children) were studied...
March 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26692394/renal-and-bone-adverse-effects-of-a-tenofovir-based-regimen-in-the-treatment-of-hiv-infected-children-a-systematic-review
#16
Rose I Okonkwo, Anita E Weidmann, Emmanuel E Effa
INTRODUCTION: Tenofovir disoproxil fumarate (TDF)-containing regimens in the treatment of HIV-infected children have safety concerns with respect to renal and bone toxicity. OBJECTIVE: The aim of this study was to systematically review and critically appraise the literature relating to the reported renal and bone adverse effects of TDF-based regimens in the treatment of HIV-infected children from 2 to 19 years old. METHODS: Searches were performed using the Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, OvidSP, ScienceDirect and Web of Science databases and platforms...
March 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/26679247/concentrations-of-tenofovir-lamivudine-and-efavirenz-in-mothers-and-children-enrolled-under-the-option-b-plus-approach-in-malawi
#17
Leonardo Palombi, Maria F Pirillo, Emilia Marchei, Haswell Jere, Jean-Baptiste Sagno, Richard Luhanga, Marco Floridia, Mauro Andreotti, Clementina Maria Galluzzo, Simona Pichini, Ruben Mwenda, Sandro Mancinelli, Maria Cristina Marazzi, Stefano Vella, Giuseppe Liotta, Marina Giuliano
OBJECTIVES: To evaluate antiretroviral drug concentrations in mothers and infants enrolled under the Option B-Plus approach for the prevention of HIV mother-to-child transmission in Malawi and to assess the maternal virological response after 1 year of treatment. PATIENTS AND METHODS: Forty-seven women and 25 children were studied. Mothers were administered during pregnancy a combination of tenofovir, lamivudine and efavirenz and continued it during breastfeeding (up to 2 years) and thereafter...
April 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26639114/the-physical-and-psychological-effects-of-hiv-infection-and-its-treatment-on-perinatally-hiv-infected-children
#18
Rachel C Vreeman, Michael L Scanlon, Megan S McHenry, Winstone M Nyandiko
INTRODUCTION: As highly active antiretroviral therapy (HAART) transforms human immunodeficiency virus (HIV) into a manageable chronic disease, new challenges are emerging in treating children born with HIV, including a number of risks to their physical and psychological health due to HIV infection and its lifelong treatment. METHODS: We conducted a literature review to evaluate the evidence on the physical and psychological effects of perinatal HIV (PHIV+) infection and its treatment in the era of HAART, including major chronic comorbidities...
2015: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/26536626/cost-effectiveness-and-cost-thresholds-of-generic-and-brand-drugs-in-a-national-chronic-hepatitis-b-treatment-program-in-china
#19
Mehlika Toy, David W Hutton, Samuel K So
Chronic liver disease and liver cancer associated with chronic hepatitis B (CHB) are leading causes of death among adults in China. Although newborn hepatitis B immunization has successfully reduced the prevalence of CHB in children, about 100 million Chinese adults remain chronically infected. If left unmanaged, 15-25% will die from liver cancer or liver cirrhosis. Antiviral treatment is not necessary for all patients with CHB, but when it is indicated, good response to treatment would prevent disease progression and reduce disease mortality and morbidity, and costly complications...
2015: PloS One
https://www.readbyqxmd.com/read/26369498/evaluation-of-hepatitis-b-virus-transmission-and-antiviral-therapy-among-hepatitis-b-surface-antigen-positive-pregnant-women
#20
Suda Tekin Koruk, Ayse Batirel, Sukran Kose, Sila Cetin Akhan, Bilgehan Aygen, Necla Tulek, Çigdem Hatipoglu, Cemal Bulut, Orhan Yıldız, Cahide Sacligil, Fatma Sirmatel, Elif Altunok
AIM: The aim of the present study was to assess the potential risk of hepatitis B virus (HBV) vertical transmission among Turkish parturient women and to evaluate the efficacy and safety of antiviral agents. MATERIAL AND METHODS: Data were collected retrospectively from 114 HBV-infected pregnant women and their infants in eight health institutions in Turkey. RESULTS: The baseline characteristics of the women were: mean age, 28.3 ± 5.2 years; alanine aminotransferase, 57...
December 2015: Journal of Obstetrics and Gynaecology Research
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