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Streptococcus pneumoniae in childrens

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https://www.readbyqxmd.com/read/29780750/the-luxs-ai-2-quorum-sensing-system-of-streptococcus-pneumoniae-is-required-to-cause-disease-and-to-regulate-virulence-and-metabolism-related-genes-in-a-rat-model-of-middle-ear-infection
#1
Mukesh K Yadav, Jorge E Vidal, Yoon Y Go, Shin H Kim, Sung-Won Chae, Jae-Jun Song
Objective: Streptococcus pneumoniae colonizes the nasopharynx of children, and from nasopharynx it could migrate to the middle ear and causes acute otitis media (AOM). During colonization and AOM, the pneumococcus forms biofilms. In vitro biofilm formation requires a functional LuxS/AI-2 quorum-sensing system. We investigated the role of LuxS/AI-2 signaling in pneumococcal middle ear infection, and identified the genes that are regulated by LuxS/AI-2 during pneumococcal biofilm formation. Methods: Streptococcus pneumoniae D39 wild-type and an isogenic D39Δ luxS strain were utilized to evaluate in vitro biofilm formation, and in vivo colonization and epithelial damage using a microtiter plate assay and a rat model of pneumococcal middle ear infection, respectively...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29778517/production-and-efficacy-of-a-low-cost-recombinant-pneumococcal-protein-polysaccharide-conjugate-vaccine
#2
Jenny A Herbert, Emily J Kay, Sian E Faustini, Alex Richter, Sherif Abouelhadid, Jon Cuccui, Brendan Wren, Timothy J Mitchell
Streptococcus pneumoniae is the leading cause of bacterial pneumonia. Although this is a vaccine preventable disease, S. pneumoniae still causes over 1 million deaths per year, mainly in children under the age of five. The biggest disease burden is in the developing world, which is mainly due to unavailability of vaccines due to their high costs. Protein polysaccharide conjugate vaccines are given routinely in the developed world to children to induce a protective antibody response against S. pneumoniae. One of these vaccines is Prevnar13, which targets 13 of the 95 known capsular types...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29765237/comparative-genomic-analysis-of-multidrug-resistant-streptococcus-pneumoniae-isolates
#3
Fen Pan, Hong Zhang, Xiaoyan Dong, Weixing Ye, Ping He, Shulin Zhang, Jeff Xianchao Zhu, Nanbert Zhong
Introduction: Multidrug resistance in Streptococcus pneumoniae has emerged as a serious problem to public health. A further understanding of the genetic diversity in antibiotic-resistant S. pneumoniae isolates is needed. Methods: We conducted whole-genome resequencing for 25 pneumococcal strains isolated from children with different antimicrobial resistance profiles. Comparative analysis focus on detection of single-nucleotide polymorphisms (SNPs) and insertions and deletions (indels) was conducted...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29755958/gut-microbiota-contributes-to-resistance-against-pneumococcal-pneumonia-in-immunodeficient-rag-mice
#4
Krysta M Felix, Ivan A Jaimez, Thuy-Vi V Nguyen, Heqing Ma, Walid A Raslan, Christina N Klinger, Kristian P Doyle, Hsin-Jung J Wu
Streptococcus pneumoniae causes infection-related mortality worldwide. Immunocompromised individuals, including young children, the elderly, and those with immunodeficiency, are especially vulnerable, yet little is known regarding S. pneumoniae- related pathogenesis and protection in immunocompromised hosts. Recently, strong interest has emerged in the gut microbiota's impact on lung diseases, or the "gut-lung axis." However, the mechanisms of gut microbiota protection against gut-distal lung diseases like pneumonia remain unclear...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29754466/temporal-trends-in-paediatric-bacterial-meningitis-in-a-tropical-australian-region-1992-2014
#5
Stephanie White, Hala Katf, Rob Baird, Joshua Francis
AIM: The epidemiology of community-acquired bacterial meningitis has changed following the introduction of routine immunisation against common causative organisms. Indigenous children living in the Northern Territory, Australia, have high rates of bacterial infections. This study describes changes in the epidemiology of childhood bacterial meningitis and the distribution of the burden of disease in the Top End. METHODS: A retrospective review of cases derived from hospital medical records and laboratory data was performed...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29751582/whole-exome-sequencing-identifies-new-host-genomic-susceptibility-factors-in-empyema-caused-by-streptococcus-pneumoniae-in-children-a-pilot-study
#6
Antonio Salas, Jacobo Pardo-Seco, Ruth Barral-Arca, Miriam Cebey-López, Alberto Gómez-Carballa, Irene Rivero-Calle, Sara Pischedda, María-José Currás-Tuala, Jorge Amigo, José Gómez-Rial, Federico Martinón-Torres
Pneumonia is the leading cause of death amongst infectious diseases. Streptococcus pneumoniae is responsible for about 25% of pneumonia cases worldwide, and it is a major cause of childhood mortality. We carried out a whole exome sequencing (WES) study in eight patients with complicated cases of pneumococcal pneumonia (empyema). An initial assessment of statistical association of WES variation with pneumonia was carried out using data from the 1000 Genomes Project (1000G) for the Iberian Peninsula (IBS) as reference controls...
May 3, 2018: Genes
https://www.readbyqxmd.com/read/29746496/pharyngeal-colonization-and-drug-resistance-profiles-of-morraxella-catarrrhalis-streptococcus-pneumoniae-staphylococcus-aureus-and-haemophilus-influenzae-among-hiv-infected-children-attending-art-clinic-of-felegehiwot-referral-hospital-ethiopia
#7
Wondemagegn Mulu, Endalew Yizengaw, Megbaru Alemu, Daniel Mekonnen, Derese Hailu, Kassaw Ketemaw, Bayeh Abera, Mulugeta Kibret
BACKGROUND: Asymptomatic pharyngeal colonization by potential bacteria is the primary reservoir for bacterial species within a population and is considered a prerequisite for development of major childhood diseases such as sinusitis, otitis media, pneumonia, bacteremia, and meningitis. However, there is dearth of data on the colonization and drug resistance pattern of the main bacterial pathogens in the pharynx of HIV infected children in Ethiopia. Therefore, this study determined the pharyngeal colonization and drug resistance profile of bacterial pathogens in HIV infected children attending ART clinic of Felegehiwot Referral Hospital (FHRH), Amhara Region, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29742648/comparison-of-bacterial-culture-results-obtained-from-nasopharyngeal-and-mid-turbinate-swabs-in-children-with-upper-respiratory-tract-infection-symptoms
#8
Judith M Martin, Anita Simonian, Gysella Muniz, Michael Green, Nader Shaikh
Paired NP and MT swabs were obtained from 96 children (mean age 2.45 years) with upper respiratory tract symptoms. Of these, 38.5% were colonized with Streptococcus pneumoniae only, 16.7% with Haemophilus influenzae only, 9.4% with both bacteria. Bacterial cultures from paired NP and MT swabs demonstrated agreement for S. pneumoniae (Kappa=0.75), H. influenzae (K=0.59) and for both pathogens (K=0.62).
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29736610/occult-bacteremia-etiology-following-the-introduction-of-13-valent-pneumococcal-conjugate-vaccine-a-multicenter-study-in-spain
#9
Susanna Hernández-Bou
Little is known about occult bacteremia (OB) in Spain following the introduction of the 13-valent pneumococcal conjugated vaccine (PCV13). Our aim was to describe the microbiologic characteristics and management of OB among children aged 3-36 months in Spain in the era of PCV13. Data were obtained from a multicenter registry of positive blood cultures collected at 22 Spanish emergency departments (ED). Positive blood cultures performed on patients aged 3-36 months from 2011 to 2015 were retrospectively identified...
May 7, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29728840/evaluation-of-the-current-use-of-imaging-modalities-and-pathogen-detection-in-children-with-acute-osteomyelitis-and-septic-arthritis
#10
Nora Manz, Andreas H Krieg, Ulrich Heininger, Nicole Ritz
Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a retrospective cohort study was done. Patients admitted with acute OM or SA between 2005 and 2014 were identified using ICD-10 discharge codes. Ninety-six children were identified: OM, n = 45; SA, n = 42; and OM + SA, n = 9. Diagnostic imaging was performed in 100% of OM or OM + SA and 95% of SA patients...
May 4, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29728757/recurrent-meningitis-in-children-etiologies-outcome-and-lessons-to-learn
#11
Amira Masri, Abeer Alassaf, Najwa Khuri-Bulos, Imad Zaq, Azmy Hadidy, Faris G Bakri
PURPOSE: Recurrent meningitis in children is a rare condition. However, its early recognition is important in order to prevent serious complications. This study aims to review cases of recurrent meningitis in children. METHODS: This is a retrospective study that included children diagnosed with recurrent meningitis and who were followed at child neurology clinic at the Jordan University Hospital from January 2001 to June 2017. RESULTS: Thirteen patients were included (nine males and four females)...
May 4, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29720431/global-distribution-of-invasive-serotype-35d-streptococcus-pneumoniae-post-pcv13-introduction
#12
Stephanie W Lo, Rebecca A Gladstone, Andries J van Tonder, Paulina A Hawkins, Brenda Kwambana-Adams, Jennifer E Cornick, Shabir A Madhi, Susan A Nzenze, Mignon du Plessis, Rama Kandasamy, Philip E Carter, Özgen Köseoglu Eser, Pak Leung Ho, Naima Elmdaghri, Sadia Shakoor, Stuart C Clarke, Martin Antonio, Dean B Everett, Anne von Gottberg, Keith P Klugman, Lesley McGee, Robert F Breiman, Stephen D Bentley
A newly recognized pneumococcal serotype 35D, which differs from the 35B polysaccharide in structure and serology by not binding to factor serum 35a, was recently reported. The genetic basis for this distinctive serology is due to the presence of an inactivating mutation in wciG , which encodes an O-acetyltransferase responsible for O-acetylation of a galactofuranose. Here, we assessed the genomic data of a worldwide pneumococcal collection to identify serotype 35D isolates and understand their geographical distribution, genetic background and invasiveness potential...
May 2, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29706315/recurrent-streptococcus-pneumoniae-meningitis-and-mondini-dysplasia-association-or-causation
#13
Indar K Sharawat, Ananthanarayanan Kasinathan, Guru P Peruri, Arushi G Saini, Naveen Sankhyan, Akshay K Saxena, Paramjeet Singh
Mondini dysplasia is a developmental disorder of the inner ear structures and it is a rare cause of recurrent bacterial meningitis in children. A 10-year-old boy presented with acute febrile encephalopathy and right ear pain. In the past, he had suffered from two distinct episodes of pyogenic meningitis. On examination, he had signs of meningeal irritation and right ear sensorineural deafness. Magnetic resonance imaging of the brain and computerized tomography of the temporal bone was suggestive of Mondini dysplasia in the right ear...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29699525/risk-factors-for-carriage-of-streptococcus-pneumoniae-in-children
#14
Maria G Koliou, Kyriaki Andreou, Demetris Lamnisos, Giagkos Lavranos, Paris Iakovides, Christos Economou, Elpidoforos S Soteriades
BACKGROUND: During the past decades Streptococcus pneumoniae has developed significant resistance to many classes of antimicrobial drugs. Potential risk factors for colonization of the nasopharynx by Streptococcus pneumoniae in children and for carriage of drug resistant strains were examined. METHODS: Between 2007 and 2008 nasopharyngeal swabs were collected from 402 children 6 months to 5 years old visiting the public sector immunization centers and outpatient departments as well as offices of paediatricians from private practice in Nicosia district in Cyprus...
April 26, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29688138/antibody-responses-against-streptococcus-pneumoniae-haemophilus-influenzae-and-moraxella-catarrhalis-in-children-with-acute-respiratory-infection-with-or-without-nasopharyngeal-bacterial-carriage
#15
Dafne C Andrade, Igor C Borges, Maiara L Bouzas, Juliana R Oliveira, Helena Käyhty, Olli Ruuskanen, Cristiana Nascimento-Carvalho
BACKGROUND: We studied Immunoglobulin G (IgG) antibody responses against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in young children with acute viral type respiratory infection and analyzed the findings in a multivariate model including age, nasopharyngeal carriage of the tested bacteria and pneumococcal vaccination. METHODS: We included 227 children aged 6-23 months with acute respiratory infection. Nasopharyngeal aspirates were tested for bacterial carriage through detection of messenger RNA (mRNA) transcript with nCounter analysis...
April 24, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29685595/invasive-pneumococcal-disease-in-northern-alberta-not-a-red-queen-but-a-dark-horse
#16
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: The consequences of the introduction of various pneumococcal protein conjugate vaccines (PCV) for children and adults is poorly understood. OBJECTIVE: We undertook a population-based cohort study of invasive pneumococcal disease (IPD) in Northern Alberta (Canada) from 2000 to 2014, years spanning pre-and early PCV (2000-2004) vs PCV-7 (2005-2009) vs PCV-13 (2010-2014) time periods. DESIGN: We collected clinical, laboratory, and Streptococcus pneumoniae serotype information on all patients from 2000 to 2014...
April 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29675400/simultaneous-detection-of-key-bacterial-pathogens-related-to-pneumonia-and-meningitis-using-multiplex-pcr-coupled-with-mass-spectrometry
#17
Chi Zhang, Leshan Xiu, Yan Xiao, Zhengde Xie, Lili Ren, Junping Peng
Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To solve this problem, we developed and validated a 12-plex PCR coupled with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method (bacterial pathogen-mass spectrometry, BP-MS) that can be used to simultaneously screen for 11 key bacterial pathogens related to pneumonia and meningitis...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29673446/a-cross-sectional-survey-assessing-carriage-of-streptococcus-pneumoniae-in-a-healthy-population-in-xinjiang-uygur-autonomous-region-of-china
#18
Na Xie, Zhao Yun Chen, Tao Chen, Bing Qing Zhu, Li Xu, Yuan Gao, Ai Yu Zhang, Pan Zhao, Ji Wen Liu, Zhu Jun Shao
The carriage rate and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in a healthy population in China remains unclear. In this study, we collected the oropharyngeal swabs from 513 individuals in Xinjiang, China. Real-time PCR targeting the lytA gene and 12 serotypes were assessed to identify S. pneumoniae carriage. The total carriage rate of S. pneumoniae was 70.4% (361/513). The most prevalent serotypes were 19B/F, 18B/C, 5, and 6A/B. The highest carriage rate of S. pneumoniae was noted in children aged 6-10 years (88...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29663903/burden-of-influenza-in-less-than-5-year-old-children-admitted-to-hospital-with-pneumonia-in-developing-and-emerging-countries-a-descriptive-multicenter-study
#19
Cédric Dananché, Valentina Sánchez Picot, Thomas Bénet, Mélina Messaoudi, Monidarin Chou, Jianwei Wang, Jean-William Pape, Shally Awasthi, Ashish Bavdekar, Mala Rakoto-Andrianarivelo, Mariam Sylla, Pagbajabyn Nymadawa, Graciela Russomando, Florence Komurian-Pradel, Hubert Endtz, Gláucia Paranhos-Baccalà, Philippe Vanhems, On Behalf Of The Pneumonia Gabriel Network
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29649269/carriage-of-streptococcus-pneumoniae-haemophilus-influenzae-moraxella-catarrhalis-and-staphylococcus-aureus-in-indonesian-children-a-cross-sectional-study
#20
Eileen M Dunne, Chrysanti Murad, Sunaryati Sudigdoadi, Eddy Fadlyana, Rodman Tarigan, Sang Ayu Kompiyang Indriyani, Casey L Pell, Emma Watts, Catherine Satzke, Jason Hinds, Nurhandini Eka Dewi, Finny Fitry Yani, Kusnandi Rusmil, E Kim Mulholland, Cissy Kartasasmita
Streptococcus pneumoniae is an important cause of infection and commonly colonizes the nasopharynx of young children, along with other potentially pathogenic bacteria. The objectives of this study were to estimate the carriage prevalence of S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in young children in Indonesia, and to examine interactions between these bacterial species. 302 healthy children aged 12-24 months were enrolled in community health centers in the Bandung, Central Lombok, and Padang regions...
2018: PloS One
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