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Enterovirus encephalitis in children.

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https://www.readbyqxmd.com/read/29650033/enterovirus-serotypes-in-patients-with-central-nervous-system-and-respiratory-infections-in-viet-nam-1997-2010
#1
Nguyen Thi Thuy Chinh B'Krong, Ngo Ngoc Quang Minh, Phan Tu Qui, Tran Thi Hong Chau, Ho Dang Trung Nghia, Lien Anh Ha Do, Nguyen Ngoc Nhung, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan, H Rogier van Doorn, Tran Tan Thanh
BACKGROUND: Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), and are of interest as emerging viruses. Here, we typed Enterovirus A-D (EV) from central nervous system (CNS) and respiratory infections in Viet Nam. METHODS: Data and specimens from prospective observational clinical studies conducted between 1997 and 2010 were used...
April 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29624567/clinical-value-of-dorsal-medulla-oblongata-involvement-detected-with-conventional-mri-for-prediction-of-outcome-in-children-with-enterovirus-71-related-brainstem-encephalitis
#2
Kun Liu, Yongjin Zhou, Shihan Cui, Jiawen Song, Peipei Ye, Wei Xiang, Xiaoyan Huang, Yiping Chen, Zhihan Yan, Xinjian Ye
BACKGROUND: Brainstem encephalitis is the most common neurologic complication after enterovirus 71 infection. The involvement of brainstem, especially the dorsal medulla oblongata, can cause severe sequelae or death in children with enterovirus 71 infection. We aimed to determine the prevalence of dorsal medulla oblongata involvement in children with enterovirus 71-related brainstem encephalitis (EBE) by using conventional MRI and to evaluate the value of dorsal medulla oblongata involvement in outcome prediction...
April 5, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29549443/association-of-interleukin-17f-gene-polymorphisms-with-susceptibility-to-severe-enterovirus-71-infection-in-chinese-children
#3
Fei Li, Peipei Liu, Ya Guo, Zhenliang Han, Yedan Liu, Yuanyuan Wang, Long Song, Jianguo Cheng, Zongbo Chen
Enterovirus 71 (EV71) is a single-strand RNA virus that causes hand, foot and mouth disease (HFMD) in infants and young children, leading to neurological complications with significant morbidity and mortality. Unfortunately, the pathogenesis of EV71 infection is not well understood. In this study, we investigated the IL-17F rs1889570 and rs4715290 gene polymorphisms in a Chinese Han population. Severe cases and cases with EV71 encephalitis had a significantly higher frequency of the rs1889570 T/T genotype and T allele...
March 16, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29536269/molecular-detection-of-human-herpesvirus-7-dna-in-cerebrospinal-fluid-from-adult-patients-with-neurological-disorders
#4
Íñigo Corral, Susana Sainz de la Maza, Mario Rodríguez, Michal-Maciej Kawiorski, María-José López-Martínez, Juan-Carlos Galán
Neurological manifestations associated with HHV-7 have been described in primary infection in children, and very occasionally in immunocompromised adult patients. However, the role of HHV-7 reactivation as a cause of central nervous system (CNS) diseases in immunocompetent adults has not yet been defined. We retrospectively analyzed clinical and microbiological features of adults with neurological symptoms who underwent lumbar puncture and a multiplex polymerase chain reaction (PCR) for herpesviruses (HHV-1-8) and enteroviruses performed in cerebrospinal fluid (CSF), during a 4-year period...
March 13, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29531617/epidemiological-profile-of-acute-viral-encephalitis-in-a-sample-of-egyptian-children
#5
Bassant Meligy, Dalia Kadry, Iman H Draz, Huda Marzouk, Nevine R El Baroudy, Amira Sayed El Rifay
INTRODUCTION: Acute encephalitis syndrome (AES) is a considerable public health problem. AIM: This study was designed to describe the aetiology, demographic features, clinical picture, short-term outcome and risk factors of mortality of children with viral encephalitis in Egyptian children. METHODS: PCR detection of viruses in the CSF of pediatric patients admitted to the pediatric unit or ICU Cairo University Pediatric hospital presenting with encephalitis syndrome...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29515559/enterovirus-a71-proteins-structure-and-function
#6
REVIEW
Jingjing Yuan, Li Shen, Jing Wu, Xinran Zou, Jiaqi Gu, Jianguo Chen, Lingxiang Mao
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children. EV-A71 can also infect the central nervous system (CNS) and induce diverse neurological complications, such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis, or even death. Viral proteins play a crucial role in EV-A71 infection. Many recent studies have discussed the structure and function of EV-A71 proteins, and the findings reported will definitely aid the development of vaccines and therapeutic approaches...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29405145/aetiological-study-of-viruses-causing-acute-encephalitis-syndrome-in-north-west-india
#7
Jitendra Kumar Tiwari, Bharti Malhotra, Aradhana Chauhan, Hemant Malhotra, Pratibha Sharma, Farah Deeba, Khushbu Trivedi, Anjenya M Swamy
CONTEXT: Acute encephalitis syndrome (AES) is a serious public health problem, caused mainly by viruses. However, the profile of viruses causing AES in Rajasthan is not well characterised. AIMS: The present study was undertaken to identify the viruses causing AES and develop diagnostic algorithm so as to help in improved diagnosis, treatment, prevention and control. SETTINGS AND DESIGN: The present study is a hospital-based descriptive, observational study...
October 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29374213/cerebrospinal-fluid-chemokine-patterns-in-children-with-enterovirus-71-related-encephalitis
#8
Jinling Liu, Shuxian Li, Chunyan Cai, Yingchun Xu, Yuan Jiang, Zhimin Chen
Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD) as well as neurological complications, such as encephalitis. The chemokines involved in the migration of leukocytes have increasingly been implicated in infectious diseases of the central nervous system. Few studies have evaluated the levels of chemokines in HMFD children with EV71-related encephalitis. In the present study, we evaluated the cerebrospinal fluid (CSF) levels of the chemokines IL-8, RANTES, MIG, MCP-1 and IP-10 in 99 children with EV71-related encephalitis and 22 children with febrile convulsion (FC)...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323107/serological-survey-of-neutralizing-antibodies-to-eight-major-enteroviruses-among-healthy-population
#9
Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29284418/the-aetiologies-of-central-nervous-system-infections-in-hospitalised-cambodian-children
#10
Paul Turner, Kuong Suy, Le Van Tan, Pora Sar, Thyl Miliya, Nguyen Thi Thu Hong, Vu Thi Ty Hang, Nguyen Thi Han Ny, Sona Soeng, Nicholas P J Day, H Rogier van Doorn, Claudia Turner
BACKGROUND: Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia. METHODS: We did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture, multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens...
December 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29242411/mortality-in-children-with-severe-hand-foot-and-mouth-disease-in-guangxi-china
#11
Zhi-Yong Yang, Xiu-Qi Chen, Dan Sun, Dan Wei
OBJECTIVE: To analyze the clinical features of children with hand foot and mouth disease (HFMD) who died. METHODS: 331 deaths due to HFMD between 2010 and 2014 were included in this retrospective study; 15 autopsies were performed. RESULTS: Most deaths were seen in children aged below 3 y, and with enterovirus 71 infection (91%). The mean (SD) duration of HFMD from onset to death was 3.7(2.9) d. The mean (SD) age of fast progressors (from onset to death less than 4 days) was 17...
February 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29233145/suppression-of-interleukin-6-increases-enterovirus-a71-lethality-in-mice
#12
Li-Chiu Wang, Hui-Wen Yao, Chuan-Fa Chang, Shainn-Wei Wang, Shih-Min Wang, Shun-Hua Chen
BACKGROUND: Enterovirus A71 (EV-A71) infection can induce fatal encephalitis in young children. Clinical reports show that interleukin-6 (IL-6) levels in the serum and cerebrospinal fluid of infected patients with brainstem encephalitis are significantly elevated. We used a murine model to address the significance of endogenous IL-6 in EV-A71 infection. RESULTS: EV-A71 infection transiently increased serum and brain IL-6 protein levels in mice. Most importantly, absence of IL-6 due to gene knockout or depletion of IL-6 using neutralizing monoclonal antibody enhanced the mortality and tissue viral load of infected mice...
December 12, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29165766/clinical-analysis-of-59-children-with-hand-foot-and-mouth-diseases-due-to-enterovirus-ev71-and-concomitant-viral-encephalitis
#13
M-G Wang, H-M Sun, X-M Liu, X-Q Deng
OBJECTIVE: To analyzed the clinical features of children with HFMD and viral encephalitis and to summarize some treatments. PATIENTS AND METHODS: A total of 59 children with HFMD were included in this study. All children underwent complete blood count, blood biochemical test cerebrospinal fluid examination, chest X-ray and brain MRI. RESULTS: One child died 24 hours after admission due to central respiratory failure with myocardial damage...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29158047/-fatal-case-of-enterovirus-a71-hand-foot-and-mouth-disease-infection
#14
V Corvest, C Archimbaud, A-S L'Honneur, C Henquell, H Peigue-Lafeuille, M Decobert, A Mirand
Hand, foot, and mouth disease associated with enterovirus (EV) infections is a common pediatric pathology that is usually considered as benign. However, neurological complications of varying severity, sometimes fatal, are possible, particularly when EV-A71 is involved. Several Asian countries are regularly affected by large-scale epidemics of EV infections with substantial morbidity and mortality, where early screening and appropriate therapeutic management are a public health challenge. In 2016, Europe experienced an epidemic of unusual magnitude, associated with increasing cases of severe neurological complications in Spain and France, mainly affecting children...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29076102/epidemiological-profile-of-acute-viral-encephalitis
#15
Rajesh Kumar, Pankaj Kumar, Manoj Kumar Singh, Dipti Agarwal, Bendangienla Jamir, Shashi Khare, Samrendra Narayan
OBJECTIVE: To study the etiology and clinico-epidemiological profile of acute viral encephalitis in children with acute encephalitis syndrome (AES). METHODS: An observational study including 100 patients fulfilling the criteria for AES was conducted in children of age group 1 mo - 16 y. Viral isolation was done on RD cells, HEp-2 cells and Vero cells from the cerebrospinal fluid samples of suspected viral encephalitis (VE) cases. An enzyme immunoassay for IgM antibodies was performed for measles, mumps, Varicella zoster virus (VZV), Herpes simplex virus 1 (HSV1) and Japanese encephalitis virus (JEV)...
October 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29049009/seroepidemiology-of-coxsackievirus-b5-in-infants-and-children-in-jiangsu-province-china
#16
Fan Gao, Lianlian Bian, Xiaotian Hao, Yalin Hu, Xin Yao, Shiyang Sun, Pan Chen, Ce Yang, Ruixiao Du, Jingxin Li, Fengcai Zhu, Qunying Mao, Zhenglun Liang
Coxsackievirus B5 (CV-B5) is associated with various human diseases such as viral encephalitis, aseptic meningitis, paralysis, herpangina, and hand, foot and mouth disease (HFMD). However, there is currently no effective vaccine against CV-B5.The seroepidemiologic characteristics of CV-B5 remained unknown. A cohort study was carried out in 176 participants aged 6-35 months from January 2012 to January 2014. The serum samples were collected and tested for CV-B5 neutralizing antibodies (NtAbs) four times during these two years...
January 2, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29029128/evolution-and-spatiotemporal-dynamics-of-enterovirus-a71-subgenogroups-in-vietnam
#17
Nguyen Thi Thanh Thao, Celeste Donato, Vu Thi Huyen Trang, Nguyen Trung Kien, Ph M Mai Thuy Trang, Tran Quoc Khanh, Dang Thi Nguyet, October M Sessions, Hoang Quoc Cuong, Phan Trong Lan, Vu Thi Que Huong, H Rogier van Doorn, Dhanasekaran Vijaykrishna
Background: Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral encephalitis in children across the Asia-Pacific region, including in Vietnam, which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5, and B5) concurrently circulate in the region with a large variation in epidemic severity. The relative differences in their evolution and epidemiology were examined within Vietnam and globally. Methods: A total of 752 VP1 gene sequences were analyzed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013, along with epidemiological metadata...
December 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#18
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28854257/hrs-plays-an-important-role-for-tlr7-signaling-to-orchestrate-inflammation-and-innate-immunity-upon-ev71-infection
#19
Zhen Luo, Maolin Ge, Junbo Chen, Qibin Geng, Mingfu Tian, Zhi Qiao, Lan Bai, Qi Zhang, Chengliang Zhu, Ying Xiong, Kailang Wu, Fang Liu, Yingle Liu, Jianguo Wu
Enterovirus 71 (EV71) is an RNA virus that causes hand-foot-mouth disease (HFMD), and even fatal encephalitis in children. Although EV71 pathogenesis remains largely obscure, host immune responses may play important roles in the development of diseases. Recognition of pathogens mediated by Toll-like receptors (TLRs) induces host immune and inflammatory responses. Intracellular TLRs must traffic from the endoplasmic reticulum (ER) to the endolysosomal network from where they initiate complete signaling, leading to inflammatory response...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28806629/aseptic-meningitis-in-adults-and-children-diagnostic-and-management-challenges
#20
Bhavarth Shukla, Elizabeth A Aguilera, Lucrecia Salazar, Susan H Wootton, Quanhathai Kaewpoowat, Rodrigo Hasbun
BACKGROUND: Aseptic meningitis represents a common diagnostic and management dilemma to clinicians. OBJECTIVES: To compare the clinical epidemiology, diagnostic evaluations, management, and outcomes between adults and children with aseptic meningitis. STUDY DESIGN: We conducted a retrospective study from January 2005 through September 2010 at 9 Memorial Hermann Hospitals in Houston, TX. Patients age≥2months who presented with community-acquired aseptic meningitis with a CSF white blood cell count >5cells/mm3 and a negative Gram stain and cultures were enrolled...
September 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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