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Epstein-Barr virus encephalitis

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https://www.readbyqxmd.com/read/28513810/epstein-barr-virus-encephalitis-in-solid-organ-transplantation
#1
Jillian S Y S Y, Zhi Mei Low, Iain Abbott, Lani Shochet, John Kanellis, Richard A Kitching, Tony M Korman
Epstein-Barr virus (EBV) is typically associated with post transplant lymphoproliferative disease (PTLD) after solid organ and stem cell transplantation. However, it is rarely associated with neurological complications. We report a case of severe encephalitis complicating primary EBV infection six months post renal transplantation, and review the literature on EBV encephalitis in solid organ transplantation in adults. A 55-year-old male presented 6 months post cadaveric renal transplant with headache, fever and confusion...
May 17, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28453063/epidemiological-surveillance-of-herpes-viral-encephalitis-in-cordoba-colombia
#2
Vaneza Tique, Salim Mattar, María Freire, Eduardo Illian, Francisco Camargo, Oscar Vergara, Luiz T Moraes-Figueiredo
Objective To establish an epidemiological surveillance of viral herpes encephalitis in major hospitals of Monteria, Cordoba. Methods From September 2009 to December 2011, a descriptive study of cases of viral encephalitis was made in three hospitals in the city of Monteria. Cerebrospinal fluid (CSF) samples from 118 patients were included in the study. Clinical aspects, as well as cytochemical and microbiological analysis (Gram stain and culture) of CSF, were used for selecting the patients. Virus detection was performed by using multiplex nested PCR for Herpes simplex virus 1 and 2, Epstein Barr virus, Cytomegalovirus and Varicella zoster virus...
August 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28452096/kidney-transplant-after-hematopoietic-cell-transplant-in-pediatrics-infectious-and-immunosuppressive-considerations
#3
Christen L Ebens, Angela R Smith, Priya S Verghese
Pediatric patients requiring kidney transplant after hematopoietic cell transplant receive multiple courses of immunosuppression placing them at risk for infection. To elucidate potential risk factors for infection, we compared the immunosuppressive regimens and infectious complications of pediatric kidney transplant recipients at a single institution who had previously undergone hematopoietic cell transplant from different donors to similar patients reported in the literature. Among the initial four post-hematopoietic cell transplant kidney transplant patients reviewed, viremia episodes were universal, including BK virus, Epstein-Barr virus, and human herpesvirus-6, with one death from presumed BK virus encephalitis...
April 27, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28438128/viral-aetiologies-of-acute-encephalitis-in-a-hospital-based-south-asian-population
#4
Janarthani Lohitharajah, Neelika Malavige, Carukshi Arambepola, Jithangi Wanigasinghe, Ranjanie Gamage, Padma Gunaratne, Pyara Ratnayake, Thashi Chang
BACKGROUND: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population. METHODS: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Cerebrospinal fluid and serum were tested for conventional and emerging encephalitogenic viruses...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28358704/prevalence-of-neurotropic-viruses-in-malignant-glioma-and-their-onco-modulatory-potential
#5
Tadej Strojnik, Darja Duh, Tamara T Lah
BACKGROUND: the association between infectious agents and tumour aetiology is relevant in about 20% of cases. PATIENTS AND METHODS: We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling. RESULTS: Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28321074/epstein-barr-virus-associated-lymphoproliferative-disorder-with-encephalitis-following-anti-thymocyte-globulin-for-aplastic-anemia-resolved-with-rituximab-therapy-a-case-report-and-literature-review
#6
Kiyomi Mashima, Shingo Yano, Hiroki Yokoyama, Takeshi Saito, Tomohito Machishima, Takaki Shimada, Yuichi Yahagi, Shinobu Takahara, Katsuki Sugiyama, Yoji Ogasawara, Jiro Minami, Yutaro Kamiyama, Atsushi Katsube, Kazuhito Suzuki, Sayaka Ohshima, Hisashi Yamada, Noriko Usui, Keisuke Aiba
Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients. A 55-year-old woman with AA following ATG developed refractory fever and was diagnosed with EBV-LPD. She was successfully treated with weekly rituximab monotherapy; however, she developed EBV encephalitis. She was admitted to the intensive care unit and finally recovered from unconsciousness...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28261514/psychosis-in-a-15-year-old-female-with-herpes-simplex-encephalitis-in-a-background-of-mannose-binding-lecithin-deficiency
#7
Kenneth Asogwa, Kwame Buabeng, Amarjit Kaur
Historically, psychotic disorder has been associated with viral infection. Herpes simplex infections and Epstein-Barr virus (EBV) among other viral infections have been implicated in psychotic disorder. Of note in this case report is psychotic disorder that occurred following reactivation of herpes simplex infection in a background of mannose-binding lecithin (MBL) deficiency, childhood EBV infection, and severe psychosocial stress. Herpes simplex encephalitis (HSE) remains a significant cause of morbidity and mortality despite advancement in its treatment with intravenous acyclovir...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28062188/a-comprehensive-analysis-and-immunobiology-of-autoimmune-neurological-syndromes-during-the-zika-virus-outbreak-in-c%C3%A3%C2%BAcuta-colombia
#8
Juan-Manuel Anaya, Yhojan Rodríguez, Diana M Monsalve, Daniel Vega, Ernesto Ojeda, Diana González-Bravo, Mónica Rodríguez-Jiménez, Carlos A Pinto-Díaz, Pablo Chaparro, María L Gunturiz, Aftab A Ansari, M Eric Gershwin, Nicolás Molano-González, Carolina Ramírez-Santana, Yeny Acosta-Ampudia
We have focused on the epidemiology and immunobiology of Zika virus (ZIKV) infection and factors associated with the development of Guillain-Barré syndrome (GBS) and other neurological syndromes in Cúcuta, the capital of North Santander department, Colombia. Data of patients with ZIKV disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (R0) and the attack rates (ARs) as well as to develop epidemiological maps. Patients with neurological syndromes were contacted and their diagnoses were confirmed...
February 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28011864/combined-immunodeficiency-and-epstein-barr-virus-induced-b-cell-malignancy-in-humans-with-inherited-cd70-deficiency
#9
Hassan Abolhassani, Emily S J Edwards, Aydan Ikinciogullari, Huie Jing, Stephan Borte, Marcus Buggert, Likun Du, Mami Matsuda-Lennikov, Rosa Romano, Rozina Caridha, Sangeeta Bade, Yu Zhang, Juliet Frederiksen, Mingyan Fang, Sevgi Kostel Bal, Sule Haskologlu, Figen Dogu, Nurdan Tacyildiz, Helen F Matthews, Joshua J McElwee, Emma Gostick, David A Price, Umaimainthan Palendira, Asghar Aghamohammadi, Bertrand Boisson, Nima Rezaei, Annika C Karlsson, Michael J Lenardo, Jean-Laurent Casanova, Lennart Hammarström, Stuart G Tangye, Helen C Su, Qiang Pan-Hammarström
In this study, we describe four patients from two unrelated families of different ethnicities with a primary immunodeficiency, predominantly manifesting as susceptibility to Epstein-Barr virus (EBV)-related diseases. Three patients presented with EBV-associated Hodgkin's lymphoma and hypogammaglobulinemia; one also had severe varicella infection. The fourth had viral encephalitis during infancy. Homozygous frameshift or in-frame deletions in CD70 in these patients abolished either CD70 surface expression or binding to its cognate receptor CD27...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27879539/clinically-mild-encephalitis-encephalopathy-with-a-reversible-splenial-lesion-accompanied-by-epstein-barr-virus-hemophagocytic-lymphohistiocytosis-a-case-report-and-review-of-the-literature
#10
Hiroshi Yamaguchi, Toshiaki Ishida, Takehito Yokoi, Tsukasa Tanaka, Azusa Maruyama, Hiroaki Nagase, Daiichiro Hasegawa, Ken-Ichi Imadome, Hiroki Takeda, Yoshiyuki Kosaka, Yoshiyuki Uetani
Central nervous system involvement in hemophagocytic lymphohistiocytosis (HLH) is associated with a poor outcome. For such patients, it is unknown whether more aggressive therapies, such as intrathecal methotrexate or hydrocortisone, are inevitably required. We present a very rare case of 3-year-old Japanese girl who developed mild encephalitis/encephalopathy with a reversible splenial lesion, accompanied by Epstein-Barr virus-associated HLH, and review previous similar reports. Our case and previous reports suggest that mild encephalitis/encephalopathy with a reversible splenial lesion accompanied by Epstein-Barr virus-associated HLH has a relatively good prognosis, even in the absence of intrathecal treatments...
March 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27677103/-mr-imaging-findings-in-epstein-barr-virus-encephalitis
#11
T Lindig, B Bender, S Heckl, T Nägele, S D Ioanoviciu, M Horger
No abstract text is available yet for this article.
October 2016: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/27455967/peptide-based-viral-detection-systems-for-effective-diagnosis-of-common-viral-infections-in-india
#12
Ushanandini Mohanraj, Suresh Chander, Yashwant G Chavan
Accurate and swift detection of viruses causing diseases in humans represent continuous challenges to diagnostic and epidemiological research. Efficient and rapid diagnosis is also crucial for effective implication of diseases management strategies. Multitude approaches attempted to identify individual viruses, includes serological assays and molecular methods. Detection assays based on peptides have become increasingly substantial and indispensable for its advantages over conventional methods. This review primarily outlines the progress made in peptide based diagnostics and the challenges for commonly found viral infections in India - Influenza Virus, Chikungunya virus, Dengue virus, Rotavirus, Japanese encephalitis virus (JEV), Epstein-Barr virus (EBV), Hanta Virus, Human Immunodeficiency virus (HIV) and Hepatitis C Virus...
July 24, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27308306/csf-herpes-virus-and-autoantibody-profiles-in-the-evaluation-of-encephalitis
#13
Jenny J Linnoila, Matthew J Binnicker, Masoud Majed, Christopher J Klein, Andrew McKeon
OBJECTIVE: To report the frequency of coexisting herpes viruses (herpes simplex virus 1 [HSV-1] or HSV-2, varicella zoster virus, Epstein-Barr virus [EBV], cytomegalovirus, or human herpes virus 6 [HHV-6]) and autoantibodies in patients with encephalitis (herpes or autoimmune) in clinical laboratory service. METHODS: Three groups were evaluated for herpes viruses and antibodies: group 1-patients whose CSF was positive for a herpes virus by real-time PCR over a period of 6 months; group 2-patients whose CSF was positive for an autoimmune encephalitis-associated antibody over 5 years (e...
August 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27213062/epstein-barr-virus-encephalitis-in-an-immunocompetent-child-a-case-report-and-management-of-epstein-barr-virus-encephalitis
#14
Gulsen Akkoc, Eda Kepenekli Kadayifci, Ayse Karaaslan, Serkan Atici, Nurhayat Yakut, Sevliya Ocal Demir, Ahmet Soysal, Mustafa Bakir
Epstein-Barr virus (EBV) usually causes mild, asymptomatic, and self-limited infections in children and adults; however, it may occasionally lead to severe conditions such as neurological diseases, malignant diseases, hepatic failure, and myocarditis. Epstein-Barr virus-related neurological disorders include meningitis, encephalitis, and cranial or peripheral neuritis, which are mostly seen in immunocompromised patients. The therapeutic modalities for EBV-related severe organ damage including central nervous system manifestations are still uncertain...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27181555/autoimmune-limbic-encephalitis-and-syndrome-of-inappropriate-antidiuretic-hormone-secretion-associated-with-lamotrigine-induced-drug-rash-with-eosinophilia-and-systemic-symptoms-dress-syndrome
#15
Lale Ozisik, Mine Durusu Tanriover, Esen Saka
Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe drug hypersensitivity reaction characterized by rash, fever and multi-organ failure. Limbic encephalitis (LE) is a rare disorder characterized by cognitive dysfunction with memory disturbance, seizures and psychiatric symptoms. We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion. Discontinuation of lamotrigine, administration of methylprednisolone and intravenous immunoglobulin led to improvement...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26962357/epstein-barr-virus-encephalitis-with-substantia-nigra-involvement
#16
Tamer Çelik, Ümit Çelik, Orkun Tolunay, Mustafa Kömür, Hüseyin Başpınar, Cengiz Yılmaz, Gülen Mert, Dinçer Yıldızdaş
Infectious mononucleosis due to Epstein-Barr virus (EBV) is a usually benign systemic viral illness common in children. Many studies described nervous system manifestations of infectious mononucleosis with a wide spectrum of neurologic deficits. Neurologic complications of EBV are seen in both acute and reactivate infection. Herein, we describe a patient diagnosed by acute EBV encephalitis with substantia nigra involvement and excellent clinical recovery.
October 2015: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/26842344/transient-seizure-related-mri-abnormalities-in-a-child-with-primary-epstein-barr-virus-infection
#17
Tae Kamakura, Akiyoshi Hiraki, Masahiro Kikuchi
We describe the case of a 6-year-old girl with typical infectious mononucleosis syndrome complicated by clustered right hemiconvulsions and disturbed consciousness. Diffusion-weighted magnetic resonance imaging on admission demonstrated reduced diffusion in the left temporo-posterior cortex and pulvinar of the ipsilateral thalamus. Her neurological symptoms resolved completely by the next day, with complete disappearance of abnormal signal intensities on magnetic resonance imaging (MRI). Elevated cerebrospinal fluid interleukin (IL)-6 with normal IL-10 might indicate a neuroprotective role of IL-6 rather than injury...
June 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26820759/viral-infections-of-the-central-nervous-system-in-elderly-patients-a-retrospective-study
#18
Saverio G Parisi, Monica Basso, Claudia Del Vecchio, Samantha Andreis, Elisa Franchin, Federico Dal Bello, Silvana Pagni, Maria Angela Biasolo, Riccardo Manganelli, Luisa Barzon, Giorgio Palù
OBJECTIVES: Very few data exist on viral meningitis and encephalitis in elderly patients (>65 years old). METHODS: This study investigated the detection of herpes simplex virus (HSV), varicella zoster virus (VZV), human herpes virus 6 (HHV-6), HHV-7, HHV-8, cytomegalovirus (CMV), Epstein-Barr virus (EBV), enterovirus (EV), human adenovirus (HAdV), human parechoviruses (HPeVs), and tick-borne encephalitis virus (TBEV) through real-time PCR (RT-PCR) in patients >65 years old who had cerebrospinal fluid (CSF) tested for a suspected central nervous system infection...
March 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/26600186/transient-widespread-cortical-and-splenial-lesions-in-acute-encephalitis-encephalopathy-associated-with-primary-epstein-barr-virus-infection
#19
Shuo Zhang, Juan Feng, Yifang Shi
Infection with Epstein-Barr virus (EBV) is very common and usually occurs in childhood or early adulthood. Encephalitis/encephalopathy is an uncommon but serious neurological complication of EBV. A case of EBV-associated encephalitis/encephalopathy with involvement of reversible widespread cortical and splenial lesions is presented herein. An 8-year-old Chinese girl who presented with fever and headache, followed by seizures and drowsiness, was admitted to the hospital. Magnetic resonance imaging revealed high signal intensities on diffusion-weighted imaging in widespread cortical and splenial lesions...
January 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/26511720/neurologic-complications-caused-by-epstein-barr-virus-in-pediatric-patients
#20
Katarzyna Mazur-Melewska, Iwona Breńska, Katarzyna Jończyk-Potoczna, Paweł Kemnitz, Ilona Pieczonka-Ruszkowska, Anna Mania, Wojciech Służewski, Magdalena Figlerowicz
We retrospectively analyzed the medical documentation of 194 children infected with Epstein-Barr virus. The diagnosis was based on clinical symptoms and the presence of the viral capsid antigen IgM antibody. Patients with severe neurologic complications also underwent neurologic examination, magnetic resonance imaging (MRI), and electroencephalography (EEG). There were 2 peaks in incidence of infection; the first one in young children aged 1 to 5 years represented 62.0% of cases. The second peak (24.6% of patients) occurred in teenagers...
May 2016: Journal of Child Neurology
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