Julia W Chang, Samuel D Reyes, Emmanuelle Faure-Kumar, Sandi K Lam, Michael W Lawlor, Richard J Leventer, Sean M Lew, Paul J Lockhart, Kathryn Pope, Howard L Weiner, Noriko Salamon, Harry V Vinters, Gary W Mathern, Aria Fallah, Geoffrey C Owens
Using a targeted transcriptomics approach, we have analyzed resected brain tissue from a cohort of 53 pediatric epilepsy surgery cases, and have found that there is a spectrum of involvement of both the innate and adaptive immune systems as evidenced by the differential expression of immune-specific genes in the affected brain tissue. The specimens with the highest expression of immune-specific genes were from two Rasmussen encephalitis cases, which is known to be a neuro-immunological disease, but also from tuberous sclerosis complex (TSC), focal cortical dysplasia, and hemimegalencephaly surgery cases...
2021: Frontiers in Immunology