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Elizabeta Dadić-Hero, Rajna Knez, Jelena Rebić
Depression is an illness of modern society, which affects population of different age. Etiological factors differ, and frustration factors as a cause of depression are multiplying. Each new episode presents difficulties, both for patients and psychiatrists. Despite the increasing number of antidepressants we use in treatment, it is sometimes hard to notice an efficient antidepressant in an optimal-efficient dose. In resistant cases we apply combinations of psychopharmacs, and the choice of the same depends on the leading symptoms...
December 2014: Collegium Antropologicum
K Mlyniec, B Ostachowicz, A Krakowska, W Reczynski, W Opoka, G Nowak
Depression is the leading psychiatric disorder with a high risk of morbidity and mortality. Clinical studies report lower serum zinc in depressed patients, suggesting a strong link between zinc and mood disorders. Also copper as an antagonistic element to zinc seems to play a role in depression, where elevated concentration is observed. In the present study we investigated serum copper and zinc concentration after acute or chronic antidepressant (AD) treatment under pathological/zinc-deficient conditions. Zinc deficiency in mice was induced by a special diet administered for 6 weeks (zinc adequate diet - ZnA, contains 33...
October 2014: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Nadja P Marić, Dragan J Stojiljković, Zorana Pavlović, Miroslava Jasović-Gamsić
BACKGROUND/AIM: Antidepressants are a widely used class of drugs. The aim of this study was to investigate different aspects of antidepressant prescribing practice at University Psychiatric Clinic in Belgrade. METHODS: This cross-sectional study was carried out by retrospective analysis of the patient's medical charts. The study included all patients with antidepressant prescribed at discharge during 2009 (n = 296). The evaluation was focused on patient-related factors (socio-demographic and illness related), psychiatrist-related factors (sex and duration of working experience) and drug related factors (type of antidepressant, dose, polypharmacy and reimbursement by national health insurance)...
April 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Petr Bob, Denisa Jasova, Jiri Raboch
BACKGROUND: According to recent clinical findings epileptiform activity in temporolimbic structures may cause depressive and other psychiatric symptoms that may occur independently of any seizure in patient's history. In addition in these patients subclinical seizure-like activity with indirect clinical manifestations likely may occur in a form of various forms of cognitive, affective, memory, sensory, behavioral and somatic symptoms (the so-called complex partial seizure-like symptoms)...
2011: PloS One
E Prieto, J A Micó, J J Meana, S Majadas
Bipolar disorder is considered an important public health problem in the world. The depressive phase is the most important in terms of frequency, duration, and impairment of the quality of life. Common treatment of bipolar depression usually includes antidepressants, mood stabilizers and antipsychotics in different combinations, despite not having a specific indication for that. Quetiapine is the first drug in Europe that has obtained a specific indication for the treatment of bipolar depression, due to a pharmacologic profile that makes it to act on the three neurotransmitter systems involved in bipolar depression neurobiology...
January 2010: Actas Españolas de Psiquiatría
Philip Gorwood
Anxiety disorders and alcohol dependence have a higher co-occurence than expected by chance only. This association has a double origin, as the presence of alcohol dependence increases by 6 the risk of any anxious disorder, and the presence of an anxious disorder multiply by 3 the risk of alcohol-dependence. Interestingly, a large population-based epidemiological study performed 10 years apart clearly showed that anxiety disorders moderatly increase the risk of regular consumption in non-consumers or irregular drinkers (by 70%), does not increase ther risk of abuse in regular drinkers, but has a strong impact on the risk of alcohol dependence while already an abuser (OR = 2...
June 20, 2010: La Revue du Praticien
E P Shchukina, M A Kinkul'kina
The paper presents a study devoted to endogenous depression with a pronounced element of anxiety. The subjects, 66 patients, received antidepresive therapy with either amitriptyline or remeron. The study lasted 6 months, during which the symptoms were assessed using Hamilton Depression and Anxiety Scales. Three variants of anxious depressive conditions were revealed: anxious melancholic, anxious hypochondriac and anxious adynamic ones. Amitriptyline proved to be more efficient in treatment of patients with anxious melancholic depression...
2007: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Moisés Diago
Treatment of chronic hepatitis C (HCV) has improved during the last decade with peg Interferon ribavirin (peg IFN-riba) increasing sustained viral response from 6 to 60%. Even though, there is an increasing number of non responding patients that constitutes up to 50% of HCV in referral centers nowdays. This is an heterogenous group for diverse reasons (failure of response to monotherapies, premature drop outs) some of them biologic (genotype I, high viral load, advanced fibrosis, insulin resistance, genetic predisposicition, pharmacologic metabolism) requiring an individualized approach...
October 2005: Revista de Gastroenterología de México
Marcin Wiecheć, Marek Klimek
Premenstrual syndrome (PMS) affects 3-5% of women. It still remains controversial in diagnosis and treatment. Dynamic progress in neuroendocrinology in recent years led to PMS etiology explanation. It also influenced therapeutic approach. According to Wang et al. neuroactive steroids and their imbalance evoke PMS symptoms. That theory introduced other therapeutic interventions restoring neuroendorine balance. The newer antidepresants demonstrated excellent efficacy in treatment of somatic and emotional PMS symptoms...
2005: Przegla̧d Lekarski
L Ia Zin'kovskaia, Iu V Kidin, I V Komissarov, O G Obraztsova
Arcain and a series of the partial modulators of polyamine binding sites of NMDA receptors (spermine- and adamantyl-containing polyamines IEM-1460, IEM-1490, IEM-1592, IEM-1755) do not display (in contrast to melipramine and memantine) antidepressant-like action in the forced swimming test and reserpine-induced depression test in rats. Compounds IEM-1460, IEM-1490, IEM-1592 increase the total time of immobilization in the Porsolt test, probably, by facilitating the development of stress-induced depression. It is supposed that the prodepressant activity of these compounds is mediated by NMDA-receptors having NR1/NR2C and NR1/NR2D subunit composition...
January 2006: Eksperimental'naia i Klinicheskaia Farmakologiia
Petar Draca, Branislava Jakovljević
INTRODUCTION: The authors analyze contemporary methods of contraception. Regarding oral contraception, they point to agents which decrease the efficacy of oral contraception. They also deal with agents which increase the level of estrogen, thus increasing side effects (paracetamol, vitamin C). ORAL CONTRACEPTIVES: Oral contraceptives may also have an impact on the efficacy of some medications (anticonvulsants, antidepresants). Health risks of oral contraceptives are also mentioned, as well as WHO's, guidelines for women using contraceptives based on risks and benefits...
May 2005: Medicinski Pregled
Mutsuko Shirai, Yoshichika Kawai, Rintaro Yamanishi, Junji Terao
Oxidative stress is frequently mentioned in relation to the neurodegenerative diseases. This study examined the effect of three herb extracts, Hypericum perforatum, Ginkgo biloba L. and Apocynum venetum L., and their components on lipid hydroperoxide-induced oxidative stress in PC-12 cells. Among them, the extract of Apocynum venetum and its components showed the remarkable inhibitory effect, indicating that this herb extract serves as a protective agent against lipid peroxidation-related oxidative stress in CNS...
November 2005: Journal of Medical Investigation: JMI
No abstract text is available yet for this article.
April 1961: Diseases of the Nervous System
Dara C Bultman, Bonnie L Svarstad
OBJECTIVE: To examine the effects of pharmacist monitoring on patient satisfaction with and adherence to antidepressant medication therapy. DESIGN: In this prospective field study, we interviewed patients starting an antidepressant after a new prescription was dispensed and again 2 months later. The first interview assessed patients' characteristics, antidepressant medication history, knowledge of antidepresant medications and their use, and beliefs about antidepressant medications...
January 2002: Journal of the American Pharmaceutical Association: APhA
A J Lang, M B Stein
Anxiety symptoms in older patients frequently coexist with depression, medical illness, and dementia, which complicate diagnosis and treatment. Most anxiety disorders do not begin in later life but are a recurrence or worsening of a pre-existing condition. Anxiety should be considered in any older patient with depressive symptoms or somatic complaints that are not explained by physical examination. Older patients may benefit from cognitive-behavioral therapy and relaxation training. Antidepresants, particularly selective serotonin reuptake inhibitors, are the preferred medical treatment...
May 2001: Geriatrics
M T Barnés, J Bascuñana, B García, J L Alvarez-Sala
Acute eosinophilic pneumonia is a severe syndrome characterized by fever, lung infiltrates, blood eosinophilia and respiratory failure. We describe a case of acute eosinophilic pneumonia associated with clomipramine and sertraline. A 40-year-old woman was admitted to the emergency department with 37.9 degrees C and respiratory rate of 35 respirations per minute. Blood analysis showed PaO2 = 57.6 mm Hg and HCO3- = 21.7 mmol/l and 12.2% eosinophils. Chest X-ray showed infiltrates in both lower lobes. She was taking clomipramine 25 mg bid for the last 4 weeks and sertraline 50 mg/day for the last week...
October 1999: Pharmacy World & Science: PWS
A T Perkins, J C Morgenlander
In the Western world, diabetes is the biggest cause of peripheral neuropathy, usually distal symmetric polyneuropathy but some times another polyneuropathy or a focal neuropathy. In addition, hypothyroidism and acromegaly can cause carpal tunnel syndrome and other sensory complaints. A complete blood cell count, nerve-conduction tests, thyroid-function tests (needed in all patients with carpal tunnel syndrome), and when necessary, needle electromyography can help confirm the diagnosis. Treatment of underlying disease is the most successful management approach: Tight glucose control in diabetic patients, thyroid hormone replacement therapy in patients with hypothyroidism, and removal of the pituitary adenoma in patients with acromegaly are of proven benefit...
September 1997: Postgraduate Medicine
A Graudins, C Vossler, R Wang
This report describes a patient with an acute intentional fluoxetine exposure who developed unique cardiovascular and neurovascular toxicity. The patient presented with lethargy and cardiac conduction delays (QRS 110 msec, QTc 458 msec) and developed a delayed seizure. On admission, therapy with intravenous sodium bicarbonate promptly narrowed the QRS to 90 msec. A comprehensive toxicology screen demonstrated only a serum fluoxetine concentration of 901 ng/mL (therapeutic range, 37-301), a serum norfluoxetine concentration of 451 ng/mL (29-329) and a serum acetaminophen concentration of 174 mg/L...
September 1997: American Journal of Emergency Medicine
E Richelson
Catecholamines, especially norepinephrine (NE) and serotonin (5-hydroxytryptamine [5-HT]), have been implicated in the pathophysiology of depression. However, their exact roles and their interrelationship are not completely understood. Antidepressants have various effects on the body, including action at the neuronal synapses of the brain; the two most important of these effects are blockade of the reuptake of neurotransmitters, including NE, 5-HT, and dopamine, and blockade of certain neurotransmitter receptors...
June 1996: Journal of Clinical Psychopharmacology
Y Sakai, T Deguchi
Studies were carried out to evaluate the antidepressant action of Mianserin as related to noradrenergic and serotonergic systems. The actions of known tricyclic anti-depressants were comparatively investigated together with Mianserin (Organon). Self-stimulation behavior induced by stimulation of the posterior hypothalamus and substantia nigra was unaffected by Mianserin and imipramine, was suppressed with chlorpromazine and markedly enhanced by methamphetamine. The enhancement due to methamphetamine was suppressed by both Mianserin and chlorpromazine, and was potentiated by imipramine...
April 1980: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
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