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https://www.readbyqxmd.com/read/28711017/alginate-gelatin-scaffolds-incorporated-with-silibinin-loaded-chitosan-nanoparticles-for-bone-formation-in-vitro
#1
R S Leena, M Vairamani, N Selvamurugan
Silibinin is a plant derived flavonolignan known for its multiple biological properties, but its role in the promotion of bone formation has not yet been well studied. Moreover, the delivery of Silibinin is hindered by its complex hydrophobic nature, which limits its bioavailability. Hence, in this study, we fabricated a drug delivery system using chitosan nanoparticles loaded with Silibinin at different concentrations (20μM, 50μM, and 100μM). They were then incorporated into scaffolds containing Alginate and Gelatin (Alg/Gel) for the sustained and prolonged release of Silibinin...
July 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28710561/genetic-architecture-of-wild-soybean-glycine-soja-response-to-soybean-cyst-nematode-heterodera-glycines
#2
Hengyou Zhang, Qijian Song, Joshua D Griffin, Bao-Hua Song
The soybean cyst nematode (SCN) is one of the most destructive pathogens of soybean plants worldwide. Host-plant resistance is an environmentally friendly method to mitigate SCN damage. To date, the resistant soybean cultivars harbor limited genetic variation, and some are losing resistance. Thus, a better understanding of the genetic mechanisms of the SCN resistance, as well as developing diverse resistant soybean cultivars, is urgently needed. In this study, a genome-wide association study (GWAS) was conducted using 1032 wild soybean (Glycine soja) accessions with over 42,000 single-nucleotide polymorphisms (SNPs) to understand the genetic architecture of G...
July 14, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28708401/cryopreservation-of-proteins-using-ionic-liquids-a-case-study-of-cytochrome-c
#3
Takahiro Takekiyo, Yuka Ishikawa, Yukihiro Yoshimura
Aqueous ionic liquid (IL) solutions form a glassy state at 77 K over a wide concentration of ILs. They have potential as novel cryopreservation/refolding solvents for proteins. However, even if proteins in glass-forming concentrations of ILs are preserved at 77 K, the recovery of activity and the structure of the proteins after cryopreservation are still unclear. To achieve high recovery of protein activity and structure by removal of ILs after cryopreservation at 77 K, we studied the recovery of activity and structural stability after cryopreservation of bovine heart cytochrome c in aqueous solutions with ILs, including ethylammonium nitrate (EAN) and 1-butyl-3-methylimidazolium thiocyanate ([bmim][SCN]) over wide IL concentrations using UV-Vis, Fourier transform infrared (FTIR), and circular dichroism (CD) spectroscopy...
July 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28704069/potent-synchronization-of-peripheral-circadian-clocks-by-glucocorticoid-injections-in-per2-luc-clock-clock-mice
#4
Mayo Kamagata, Yuko Ikeda, Hiroyuki Sasaki, Yuta Hattori, Shinnosuke Yasuda, Shiho Iwami, Miku Tsubosaka, Ryosuke Ishikawa, Ai Todoh, Konomi Tamura, Yu Tahara, Shigenobu Shibata
In mammals, the central clock (the suprachiasmatic nuclei, SCN) is entrained mainly by the light-dark cycle, whereas peripheral clocks in the peripheral tissues are entrained/synchronized by multiple factors, including feeding patterns and endocrine hormones such as glucocorticoids. Clock-mutant mice (Clock/Clock), which have a mutation in a core clock gene, show potent phase resetting in response to light pulses compared with wild-type (WT) mice, owing to the damped and flexible oscillator in the SCN. However, the phase resetting of the peripheral clocks in Clock/Clock mice has not been elucidated...
July 13, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28699644/roles-of-apol1%C3%A2-g1-and-g2-variants-in-sickle-cell-disease-patients-kidney-is-the-main-target
#5
Raphaël Kormann, Anne-Sophie Jannot, Céline Narjoz, Jean-Antoine Ribeil, Sandra Manceau, Marianne Delville, Valentin Joste, Dominique Prié, Jacques Pouchot, Eric Thervet, Marie Courbebaisse, Jean-Benoît Arlet
In African-American patients with sickle cell disease (SCD), APOL1 G1 and G2 variants are associated with increased risk of sickle cell nephropathy (SCN). To determine the role of APOL1 variants in SCD patients living in Europe, we genotyped 152 SCD patients [aged 30·4 (24·3-36·4) years], mainly of Sub-Saharan African ancestry, for APOL1 G1 and G2 and for variants of four genes with kidney tropism (GSTM1, GSTT1, GSTP1, and HMOX1). Homozygous or double-heterozygous APOL G1 and G2 genotypes were strongly associated with end stage renal disease (P = 0·003) and worse Kidney Disease: Improving Global Outcomes stages (P = 0·001)...
July 12, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28698388/delayed-cryptochrome-degradation-asymmetrically-alters-the-daily-rhythm-in-suprachiasmatic-clock-neuron-excitability
#6
Sven Wegner, Mino D C Belle, Alun T L Hughes, Casey O Diekman, Hugh D Piggins
Suprachiasmatic nuclei (SCN) neurons contain an intracellular molecular circadian clock and the Cryptochromes (CRY1/2), key transcriptional repressors of this molecular apparatus, are subject to post-translational modification through ubiquitination and targeting for proteosomal degradation by the ubiquitin E3 ligase complex. Loss-of-function point mutations in a component of this ligase complex, Fbxl3, delay CRY1/2 degradation, reduce circadian rhythm strength, and lengthen the circadian period by ∼2.5h...
July 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28696713/modulation-of-the-binding-affinity-of-polyzwitterion-conjugated-protein-by-ion-specific-effects-in-crowded-environments
#7
Wangqin Song, Jie Zhu, Lvdan Liu, Guangming Liu
Macromolecular crowding could influence the binding affinity of the polyzwitterion-conjugated proteins. Herein, the hydrolysis of N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide by the poly(carboxybetaine) conjugated α-chymotrypsin (PCT) was employed as a model system to investigate the modulation of the binding affinity of the polyzwitterion-conjugated proteins by the ion-specific effects in the crowded environments. In comparison with the bare α-chymotrypsin (BCT), the binding affinity of the PCT to the peptide is stronger in the dilute solutions but becomes weaker in the crowded environments...
July 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28692766/vertically-oriented-2d-layered-perovskite-solar-cells-with-enhanced-efficiency-and-good-stability
#8
Xinqian Zhang, Gang Wu, Shida Yang, Weifei Fu, Zhongqiang Zhang, Chen Chen, Wenqing Liu, Jielin Yan, Weitao Yang, Hongzheng Chen
Vertically oriented highly crystalline 2D layered (BA)2 (MA)n-1 Pbn I3n+1 (BA = CH3 (CH2 )3 NH3 , MA = CH3 NH3 , n = 3, 4) perovskite thin-films are fabricated with the aid of ammonium thiocyanate (NH4 SCN) additive through one-step spin-coating process. The humidity-stability of the film is certified by the almost unchanged X-ray diffraction patterns after exposed to humid atmosphere (Hr = 55 ± 5%) for 40 d. The photovoltaic devices with the structure of indium tin oxide(ITO)/poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/(BA)2 (MA)n-1 Pbn I3n+1 (n = 3,4)/[6,6]-phenyl-C61 -butyric acid methyl ester/Bathocuproine/Ag are fabricated...
July 10, 2017: Small
https://www.readbyqxmd.com/read/28689605/circadian-disruptions-in-the-myshkin-mouse-model-of-mania-are-independent-of-deficits-in-suprachiasmatic-molecular-clock-function
#9
Joseph W S Timothy, Natasza Klas, Harshmeena R Sanghani, Taghreed Al-Mansouri, Alun T L Hughes, Greer S Kirshenbaum, Vincent Brienza, Mino D C Belle, Martin R Ralph, Steven J Clapcote, Hugh D Piggins
BACKGROUND: Alterations in environmental light and intrinsic circadian function have strong associations with mood disorders. The neural origins underpinning these changes remain unclear, although genetic deficits in the molecular clock regularly render mice with altered mood-associated phenotypes. METHODS: A detailed circadian and light-associated behavioral characterization of the Na(+)/K(+)-ATPase α3 Myshkin (Myk/+) mouse model of mania was performed. Na(+)/K(+)-ATPase α3 does not reside within the core circadian molecular clockwork, but Myk/+ mice exhibit concomitant disruption in circadian rhythms and mood...
May 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28687372/effects-of-a-free-choice-high-fat-high-sugar-diet-on-brain-per2-and-bmal1-protein-expression-in-mice
#10
Aurea Blancas-Velazquez, Susanne E la Fleur, Jorge Mendoza
The suprachiasmatic nucleus (SCN) times the daily rhythms of behavioral processes including feeding. Beyond the SCN, the hypothalamic arcuate nucleus (ARC), involved in feeding regulation and metabolism, and the epithalamic lateral habenula (LHb), implicated in reward processing, show circadian rhythmic activity. These brain oscillators are functionally coupled to coordinate the daily rhythm of food intake. In rats, a free choice high-fat high-sugar (fcHFHS) diet leads to a rapid increase of calorie intake and body weight gain...
July 5, 2017: Appetite
https://www.readbyqxmd.com/read/28681255/delayed-puberty-and-gonadal-failure-in-patients-with-hax1-mutation
#11
Sukru Cekic, Halil Saglam, Orhan Gorukmez, Tahsin Yakut, Omer Tarim, Sara S Kilic
PURPOSE: Homozygous mutations in the HAX1 gene cause an autosomal recessive form of severe congenital neutropenia (SCN). There are limited data on cases of gonadal insufficiency that involve the HAX1 gene mutation. We aimed to evaluate the pubertal development and gonadal functions of our patients with a p.Trp44X mutation in the HAX1 gene. METHOD: Pubertal development, physical and laboratory findings of one male and seven female patients with HAX1 deficiency were evaluated...
July 5, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28681191/low-back-pain-due-to-middle-cluneal-nerve-entrapment-neuropathy
#12
Kyongsong Kim, Toyohiko Isu, Juntaro Matsumoto, Kazuyoshi Yamazaki, Masanori Isobe
PURPOSE: The etiology of low back pain (LBP) is complicated and the diagnosis can be difficult. Superior cluneal nerve entrapment neuropathy (SCN-EN) is a known cause of LBP, although the middle cluneal nerve (MCN) can be implicated in the elicitation of LBP. METHODS: A 76-year-old woman with a 4-year history of severe LBP was admitted to our department in a wheelchair. She complained of bilateral LBP that was exacerbated by lumbar movement. Her pain was severe on the right side and she also suffered right leg pain and numbness...
July 5, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28679229/the-asymmetry-of-the-entrainment-range-induced-by-the-difference-in-intrinsic-frequencies-between-two-subgroups-within-the-suprachiasmatic-nucleus
#13
Changgui Gu, Huijie Yang
The rhythms of physiological and behavioral activities in mammals, which are regulated by the main clock suprachiasmatic nucleus (SCN) in the brain, can not be only synchronized to the natural 24 h light-dark cycle, but also to cycles with artificial periods. The range of the artificial periods that the animal can be synchronized to is called entrainment range. In the absence of the light-dark cycle, the animal can also maintain the circadian rhythm with an endogenous period close to 24 h. Experiments found that the entrainment range is not symmetrical with respect to the endogenous period...
June 2017: Chaos
https://www.readbyqxmd.com/read/28672143/synthesis-characterization-and-crystal-structures-of-two-pentagonal-bipyramidal-fe-iii-complexes-with-dihydrazone-of-2-6-diacetylpyridine-and-girard-s-t-reagent-anticancer-properties-of-various-metal-complexes-of-the-same-ligand
#14
Katarina Anđelković, Milica R Milenković, Andrej Pevec, Iztok Turel, Ivana Z Matić, Miroslava Vujčić, Dušan Sladić, Dušanka Radanović, Gabrijela Brađan, Svetlana Belošević, Božidar Čobeljić
In this work synthesis, characterization and crystal structures of two isothiocyanato Fe(III) complexes with 2,2'-[2,6-pyridinediylbis(ethylidyne-1-hydrazinyl-2-ylidene)]bis[N,N,N-trimethyl-2-oxoethanaminium] dichloride (H2LCl2) ligand, with composition [FeL(NCS)2]SCN·2H2O and [FeL(NCS)2]2[Fe(H2O)(NCS)5]·4H2O, has been reported. Both iron(III) complexes possess the same pentagonal-bipyramidal complex cation, while the nature of their anions depends on mole ratio of NH4SCN and FeCl3·6H2O used in reaction...
September 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28671110/alterations-of-clock-gene-rna-expression-in-brain-regions-of-a-triple-transgenic-model-of-alzheimer-s-disease
#15
Francesco Bellanti, Giuseppina Iannelli, Maria Blonda, Rosanna Tamborra, Rosanna Villani, Adele Romano, Silvio Calcagnini, Gianluigi Mazzoccoli, Manlio Vinciguerra, Silvana Gaetani, Anna Maria Giudetti, Gianluigi Vendemiale, Tommaso Cassano, Gaetano Serviddio
A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian rhythmicity is regulated by endogenous clock genes and a number of external Zeitgebers, including light. This study investigated the light induced changes in the expression of clock genes in a triple transgenic model of AD (3×Tg-AD) and their wild type littermates (Non-Tg). Changes in gene expression were evaluated in four brain areas¾suprachiasmatic nucleus (SCN), hippocampus, frontal cortex and brainstem¾of 6- and 18-month-old Non-Tg and 3×Tg-AD mice after 12 h exposure to light or darkness...
June 24, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28668516/effect-of-monochromatic-light-on-circadian-rhythmic-expression-of-clock-genes-in-the-hypothalamus-of-chick
#16
Nan Jiang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
To clarify the effect of monochromatic light on circadian clock gene expression in chick hypothalamus, a total 240 newly hatched chickens were reared under blue light (BL), green light (GL), red light (RL) and white light (WL), respectively. On the post-hatched day 14, 24-h profiles of seven core clock genes (cClock, cBmal1, cBmal2, cCry1, cCry2, cPer2 and cPer3) were measured at six time points (CT 0, CT 4, CT 8, CT 12, CT 16, CT 20, circadian time). We found all these clock genes expressed with a significant rhythmicity in different light wavelength groups...
June 23, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28666896/circadian-neurons-in-the-lateral-habenula-clocking-motivated-behaviors
#17
REVIEW
Jorge Mendoza
The main circadian clock in mammals is located in the hypothalamic suprachiasmatic nucleus (SCN), however, central timing mechanisms are also present in other brain structures beyond the SCN. The lateral habenula (LHb), known for its important role in the regulation of the monoaminergic system, contains such a circadian clock whose molecular and cellular mechanisms as well as functional role are not well known. However, since monoaminergic systems show circadian activity, it is possible that the LHb-clock's role is to modulate the rhythmic activity of the dopamine, serotonin and norephinephrine systems, and associated behaviors...
June 27, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28666173/linking-routinely-collected-social-work-education-and-health-data-to-enable-monitoring-of-the-health-and-health-care-of-school-aged-children-in-state-care-looked-after-children-in-scotland-a-national-demonstration-project
#18
D Clark, A King, K Sharpe, G Connelly, L Elliott, L M D Macpherson, A D McMahon, I Milligan, P Wilson, D I Conway, R Wood
BACKGROUND AND OBJECTIVES: Children in state care ('looked after children') have poorer health than children who are not looked after. Recent developments in Scotland and elsewhere have aimed to improve services and outcomes for looked after children. Routine monitoring of the health outcomes of looked after children compared to those of their non-looked after peers is currently lacking. Developing capacity for comparative monitoring of population-based outcomes based on linkage of routinely collected administrative data has been identified as a priority...
June 27, 2017: Public Health
https://www.readbyqxmd.com/read/28665908/small-rural-hospitals-have-a-harder-time-achieving-success-in-continuous-quality-improvement-an-example-from-a-stroke-care-network
#19
Kelley Elkins, Lisa Bellamy, Jing Guo, Michael R Dobbs
BACKGROUND: University of Kentucky HealthCare established a Stroke Care Network (SCN) in 2008 to address the challenges of rural stroke care and improve care quality. METHODS: The SCN collects quality data from each affiliate that include volumes, mortality, length of stay, turnaround times, rt-PA door-to-needle time, 8 stroke core measures, and dysphagia screen measure. Characteristics of affiliate hospital studies include number of beds, Stroke Disease-Specific Care (DSC) certification by The Joint Commission, Appalachian designated county or not, time dedicated to stroke coordinator, submission of quality data for the calendar year, success of data, and utilization of American Heart Association's Get With the Guidelines...
July 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28661071/scheduled-meal-accelerates-entrainment-to-a-6-hours-phase-advance-by-shifting-central-and-peripheral-oscillations-in-rats
#20
L M Ubaldo-Reyes, R M Buijs, C Escobar, M Ángeles-Castellanos
Traveling across several time zones requires a fast adjustment of the circadian system and the differential adjustment speeds of organs and systems results in what is commonly referred as jet lag. During this transitory state of circadian disruption, individuals feel discomfort, appetite loss, fatigue, disturbed sleep and deficient performance of multiple tasks. We have demonstrated that after a 6-h phase advance of the light-dark cycle (LD) scheduled food in phase with the new night onset can speed up re-entrainment...
June 29, 2017: European Journal of Neuroscience
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