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https://www.readbyqxmd.com/read/28637614/classical-inherited-bone-marrow-failure-syndromes-with-high-risk-for-myelodysplastic-syndrome-and-acute-myelogenous-leukemia
#1
REVIEW
Sharon A Savage, Carlo Dufour
The inherited marrow failure syndromes (IBMFS) are a heterogeneous group of diseases characterized by failure in the production of one or more blood lineage. The clinical manifestations of the IBMFS vary according to the type and number of blood cell lines involved, including different combinations of anemia, leukopenia, and thrombocytopenia. In some IBMFS, systemic non-hematologic manifestations, including congenital malformations, mucocutaneous abnormalities, developmental delay, and other medical complications, may be present...
April 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/28635274/oxidation-state-dependent-binding-properties-of-the-active-site-in-a-mo-containing-formate-dehydrogenase
#2
William E Robinson, Arnau Bassegoda, Erwin Reisner, Judy Hirst
Molybdenum-containing formate dehydrogenase H from Escherichia coli (EcFDH-H) is a powerful model system for studies of the reversible reduction of CO2 to formate. However, the mechanism of FDH catalysis is currently debated, and whether the primary Mo coordination sphere remains saturated or one of the ligands dissociates to allow direct substrate binding during turnover is disputed. Here, we describe how oxidation state-dependent changes at the active site alter its inhibitor binding properties. Using protein film electrochemistry we show that formate oxidation by EcFDH-H is inhibited strongly and competitively by N3-, OCN-, SCN-, NO2- and NO3-, whereas CO2 reduction is inhibited only weakly and not competitively...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28633941/pancreatic-cyst-fluid-vascular-endothelial-growth-factor-a-and-carcinoembryonic-antigen-a-highly-accurate-test-for-the-diagnosis-of-serous-cystic-neoplasm
#3
Rosalie A Carr, Michele T Yip-Schneider, Scott Dolejs, Bradley A Hancock, Huangbing Wu, Milan Radovich, C Max Schmidt
BACKGROUND: Accurate differentiation of pancreatic cystic lesions is important for pancreatic cancer early detection and prevention as well as avoidance of unnecessary surgical intervention. Serous cystic neoplasms (SCN) have no malignant potential, but may mimic premalignant mucinous cystic lesions: mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm (IPMN). We recently identified vascular endothelial growth factor (VEGF)-A as a novel pancreatic fluid biomarker for SCN...
May 18, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28623226/entraining-to-the-polar-day-circadian-rhythms-in-arctic-ground-squirrels
#4
Cory T Williams, Brian M Barnes, Lily Yan, C Loren Buck
Circadian systems are principally entrained to 24h light/dark cycles, but this cue is seasonally absent in polar environments. Although some resident polar vertebrates have weak circadian clocks and are seasonally arrhythmic, the arctic ground squirrel (AGS) maintains daily rhythms of physiology and behavior throughout the summer, which includes six weeks of constant daylight. Here, we show that persistent daily rhythms in AGS are maintained through a circadian system that readily entrains to the polar day yet remains insensitive to entrainment by rapid light-dark transitions, which AGS generate naturally due to their semi-fossorial behavior...
June 16, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28621790/molecular-interactions-and-thermal-transport-in-ionic-liquids-with-carbon-nanomaterials
#5
João M P França, Carlos A Nieto de Castro, Agílio A H Pádua
We used molecular dynamics simulation to study the effect of suspended carbon nanomaterials, nanotubes and graphene sheets, on the thermal conductivity of ionic liquids, an issue related to understanding the properties of nanofluids. One important aspect that we developed is an atomistic model of the interactions between the organic ions and carbon nanomaterials, so we did not rely on existing force fields for small organic molecules or assume simple combining rules to describe the interactions at the liquid/material interface...
June 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28621294/endoscopic-ultrasound-with-tissue-sampling-is-accurate-in-the-diagnosis-and-subclassification-of-gastrointestinal-spindle-cell-neoplasms
#6
Dalbir Singh Sandhu, Adrian N Holm, Rami El-Abiad, Carolyn Rysgaard, Chris Jensen, Henning Gerke
BACKGROUND AND OBJECTIVES: Mesenchymal (spindle cell) neoplasms (SCN) of the gastrointestinal (GI) tract are an important subtype of subepithelial lesions that need subclassification to assess their malignant potential. Reported success rates of accurate subclassification with endoscopic ultrasound (EUS)-guided biopsies are variable. Our goal was to analyze our experience using EUS-guided TruCut biopsy (EUS-TCB) in the majority of patients. METHODS: Retrospective analysis in patients who underwent EUS with biopsies for suspected SCN at our tertiary referral center between 2004 and 2013...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28617189/stability-of-continuous-and-fed-batch-sequential-anaerobic-anoxic-aerobic-moving-bed-bioreactor-systems-at-phenol-shock-load-application
#7
Biju Prava Sahariah, J Anandkumar, Saswati Chakraborty
In this study, stability of two sequential moving bed bioreactor systems for phenol shock load (PSL) applications was assessed in presence of thiocyanate and ammonia. The systems were operated in anaerobic-anoxic-aerobic continuous (CMBR: R1-R2-R3) and semi-continuous (FMBR: B1-B2-B3) mode. Both systems were exposed to 3000 mg phenol/L (PSL-I) and 3500 mg phenol/L (PSL-II) for 3 days each from initial 2500 mg phenol/L without any intermediate concentration at 6 days HRT. The effect of PSL-I on R1 was reversible within 10-12 days...
June 15, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28615053/loci-and-candidate-genes-conferring-resistance-to-soybean-cyst-nematode-hg-type-2-5-7
#8
Xue Zhao, Weili Teng, Yinghui Li, Dongyuan Liu, Guanglu Cao, Dongmei Li, Lijuan Qiu, Hongkun Zheng, Yingpeng Han, Wenbin Li
BACKGROUND: Soybean (Glycine max L. Merr.) cyst nematode (SCN, Heterodera glycines I,) is a major pest of soybean worldwide. The most effective strategy to control this pest involves the use of resistant cultivars. The aim of the present study was to investigate the genome-wide genetic architecture of resistance to SCN HG Type 2.5.7 (race 1) in landrace and elite cultivated soybeans. RESULTS: A total of 200 diverse soybean accessions were screened for resistance to SCN HG Type 2...
June 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28613354/the-quantitative-measurements-of-vascular-density-and-flow-areas-of-macula-using-optical-coherence-tomography-angiography-in-normal-volunteers
#9
Fariba Ghassemi, Kaveh Fadakar, Fatemeh Bazvand, Reza Mirshahi, Masoumeh Mohebbi, Siamak Sabour
BACKGROUND AND OBJECTIVE: The quantification of the density of macular vascular networks and blood flow areas in the foveal and parafoveal area in healthy subjects using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Cross-sectional, prospective study in an institutional setting at the Retina Services of Farabi Eye Hospital. One hundred twelve normal volunteers with no known ocular or systemic disease were included, including patient numbers (one or both eyes), selection procedures, inclusion/exclusion criteria, randomization procedure, and masking...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28611281/utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-of-regional-lymph-nodes-that-are-proximal-to-and-far-from-the-primary-distal-esophageal-carcinoma
#10
Yusuke Shimodaira, Rebecca S Slack, Kazuto Harada, Manoop S Bhutani, Elena Elimova, Gregg A Staerkel, Nour Sneige, Jeremy Erasmus, Hironori Shiozaki, Nikolaos Charalampakis, Venkatram Planjery, Dilsa Mizrak Kaya, Fatemeh G Amlashi, Mariela A Blum, Heath D Skinner, Bruce D Minsky, Dipen M Maru, Wayne L Hofstetter, Stephen G Swisher, Jeannette E Mares, Jane E Rogers, Quan D Lin, William A Ross, Brian Weston, Jeffrey H Lee, Jaffer A Ajani
Implications of assessing the proximal and far para-tracheal or sub-carinal nodes (para-tracheal [PTN] or sub-carinal [SCN]) associated with lower primary esophageal carcinomas (ECs) are unclear. To evaluate the value of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) for PTN and SCN, we analyzed results by positron emission tomography (PET) avidity, 4 EUS node malignancy features, and EUS-FNA results in all patients with Siewert's I or II EC. Of 133 patients (PTN, n=102; SCN, n=31) with EUS-FNA, 47 (35%) patients had malignant node, leading to treatment modifications...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608287/increased-glutamic-acid-decarboxylase-expression-in-the-hypothalamic-suprachiasmatic-nucleus-in-depression
#11
Xueyan Wu, Rawien Balesar, Jing Lu, Sahar Farajnia, Qiongbin Zhu, Manli Huang, Ai-Min Bao
In depression, disrupted circadian rhythms reflect abnormalities in the central circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN). Although many SCN neurons are said to be GABAergic, it was not yet known whether and how SCN GABA changes occur in the SCN in depression. We, therefore, studied GABA in the SCN in relation to the changes in arginine vasopressin (AVP), which is one of the major SCN output systems. Postmortem hypothalamus specimens of 13 subjects suffering from depression and of 13 well-matched controls were collected...
June 12, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28598691/development-of-68-ga-scn-dota-capsaicin-as-an-imaging-agent-targeting-apoptosis-and-cell-cycle-arrest-in-breast-cancer
#12
Jun Young Lee, Sang-Yeun Lee, Gun Gyun Kim, Min Goo Hur, Seung Dae Yang, Jeong-Hoon Park, Sang Wook Kim
(68)Ga-labeled capsaicin using a DOTA (1,4,7,10-tetraazocyclododecane-N,N',N″,N'″-tetraacetic acid) derivative [(68)Ga-SCN-Benzyl(Bn)-DOTA-capsaicin] was studied for the diagnosis of breast cancers, such as MCF-7 and SK-BR-3. The standard compound, (69)Ga-SCN-Bn-DOTA-capsaicin, was also prepared and characterized by spectroscopic analysis. The binding affinity of (68)Ga-SCN-Bn-DOTA-capsaicin was evaluated by using breast cancer cell lines (MCF-7, SK-BR-3) and colon cancer cell (CT-26); the biodistribution was carried out by using MCF-7-bearing nude mice, after which the positron emission tomography (PET) images were obtained at different time intervals (15-120 minutes)...
June 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28598251/molecular-characterization-of-methicillin-resistant-staphylococcus-aureus-isolated-from-australian-animals-and-veterinarians
#13
Kate A Worthing, Sam Abraham, Stanley Pang, Geoffrey W Coombs, Sugiyono Saputra, David Jordan, Hui S Wong, Rebecca J Abraham, Darren J Trott, Jacqueline M Norris
This study aimed to determine the frequency and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) from Australian animals and whether animal-derived MRSA was similar to that from Australian veterinarians. A total of 1,080 clinical coagulase positive Staphylococcus isolates from Australian animals were collected during 2013. Sixteen (4%) of 360 S. aureus isolates were MRSA. Most MRSA came from companion animals, while none came from livestock. MRSA isolates were characterized using whole genome sequencing...
June 9, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28595392/transient-raman-spectra-structure-and-thermochemistry-of-the-thiocyanate-dimer-radical-anion-in-water
#14
Ireneusz Janik, Ian Carmichael, G N R Tripathi
Time-resolved resonance-enhanced Stokes and anti-Stokes Raman spectra of the thiocyanate dimer radical anion, (SCN)2(•-), prepared by pulse radiolysis in water, have been obtained and interpreted in conjunction with theoretical calculations to provide detailed information on the molecular geometry and bond properties of the species. The structural properties of the radical are used to develop a molecular perspective on its thermochemistry in an aqueous solution. Twenty-nine Stokes Raman bands of the radical observed in the 120-4200 cm(-1) region are assigned in terms of the strongly enhanced 220 cm(-1) fundamental, weakly enhanced 721 cm(-1), and moderately enhanced 2073 cm(-1) fundamentals, their overtones, and combinations...
June 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28593809/nitrate-analogs-as-attractants-for-soybean-cyst-nematode
#15
Akito Hosoi, Tsutomu Katsuyama, Yasuyuki Sasaki, Tatsuhiko Kondo, Shunsuke Yajima, Shinsaku Ito
Soybean cyst nematode (SCN) Heterodera glycines Ichinohe, a plant parasite, is one of the most serious pests of soybean. In this paper, we report that SCN is attracted to nitrate and its analogs. We performed attraction assays to screen for novel attractants for SCN and found that nitrates were attractants for SCN and SCN recognized nitrate gradients. However, attraction of SCN to nitrates was not observed on agar containing nitrate. To further elucidate the attraction mechanism in SCN, we performed attraction assays using nitrate analogs ([Formula: see text], [Formula: see text], [Formula: see text])...
June 8, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28592192/pyridine-influence-on-sequential-anaerobic-anoxic-aerobic-fmbr-system-for-phenol-thiocyanate-and-ammonia-removal
#16
Biju Prava Sahariah, J Anandkumar, Saswati Chakraborty
A synthetic wastewater containing various pyridine concentrations (25-250 mg/L) was treated in a sequential anaerobic(B1)-anoxic(B2)-aerobic(B3) fed batch moving bed reactor (FMBR) system. Pyridine was associated with phenol (1500 mg/L), SCN(-) (800 mg/L), COD (5400-5430 mg/L) and NH4(+)-N (500 mg/L) at hydraulic retention time (HRT) of 6 (B1: 3; B2 and B3: 1.5 each) days. In B1, pyridine removal was 10-12% with influent concentration 25-100mg/L and beyond it was zero. Removal of phenol (53-39%) and COD (33-22%) occurred in B1 but pyridine above 50 mg/L inhibited the COD and phenol removal...
June 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28588500/temporal-expression-patterns-of-clock-genes-and-aquaporin-5-anoctamin-1-in-rat-submandibular-gland-cells
#17
Ryouichi Satou, Masaki Sato, Maki Kimura, Yoichi Ishizuka, Masakazu Tazaki, Naoki Sugihara, Yoshiyuki Shibukawa
Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, however, the relationship between the molecular mechanism of salivary secretion and peripheral circadian rhythm is not yet clear. Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28585194/circadian-rhythms-in-diet-induced-obesity
#18
Atilla Engin
The biological clocks of the circadian timing system coordinate cellular and physiological processes and synchronizes these with daily cycles, feeding patterns also regulates circadian clocks. The clock genes and adipocytokines show circadian rhythmicity. Dysfunction of these genes are involved in the alteration of these adipokines during the development of obesity. Food availability promotes the stimuli associated with food intake which is a circadian oscillator outside of the suprachiasmatic nucleus (SCN)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28578910/e6ap-inhibits-g-csfr-turnover-and-functions-by-promoting-its-ubiquitin-dependent-proteasome-degradation
#19
Stuti Chhabra, Yogesh Kumar, Gatha Thacker, Isha Kapoor, Savita Lochab, Sabyasachi Sanyal, Madan L B Bhatt, Naibedya Chattopadhyay, Arun Kumar Trivedi
Granulocyte colony-stimulating factor receptor (G-CSFR) plays a crucial role in regulating myeloid cell survival, proliferation, and neutrophilic granulocyte precursor cells maturation. Previously, we demonstrated that Fbw7α negatively regulates G-CSFR and its downstream signaling through ubiquitin-proteasome mediated degradation. However, whether additional ubiquitin ligases for G-CSFR exist is not known. Identifying multiple E3 ubiquitin ligases for G-CSFR shall improve our understanding of activation and subsequent attenuation of G-CSFR signaling required for differentiation and proliferation...
June 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28577110/daily-chronomics-of-proteomic-profile-in-aging-and-rotenone-induced-parkinson-s-disease-model-in-male-wistar-rat-and-its-modulation-by-melatonin
#20
Anita Jagota, Ushodaya Mattam
Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels and daily pulses. To identify biomarkers of aging and PD chronomics of proteomic day-night profiles in suprachiasmatic nucleus (SCN), pineal and substantia nigra (SN) in 3 month (m), 12, 24 m and RIPD rat model were studied at two time points i...
June 2, 2017: Biogerontology
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