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https://www.readbyqxmd.com/read/28091655/probing-the-magnetic-relaxation-and-magnetic-moment-arrangement-in-a-series-of-dy4-squares
#1
Jianfeng Wu, Shuang-Yan Lin, Si Shen, Xiao-Lei Li, Lang Zhao, Li Zhang, Jinkui Tang
Three μ4-O bridged Dy4 squares, {[Dy4(μ4-O)(HL(1))4(H2O)4]2(NO3)3(OH)}·2H2O·2CH3OH (1), [Dy4(μ4-O)(HL(2))4(SCN)2]·2H2O·4CH3OH (2) and [Dy4(μ4-O)(H2L(3))2(SCN)2]·6H2O (3) were assembled by using a Schiff base ligand and its dimerized and reduced congener, respectively. These complexes share a similar μ4-O bridged Dy4 core, while, both the coordination geometry and metal-ligand interactions are slightly changed upon the modulation of the ligands, resulting in distinct single-molecular magnetic (SMM) and single-molecular toroic (SMT) properties...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28090585/circadian-forced-desynchrony-of-the-master-clock-leads-to-phenotypic-manifestation-of-depression-in-rats
#2
Miriam Ben-Hamo, Tracy A Larson, Leanne S Duge, Carl Sikkema, Charles W Wilkinson, Horacio O de la Iglesia, Mónica M C González
In mammals, a master circadian clock within the suprachiasmatic nucleus (SCN) of the hypothalamus maintains the phase coherence among a wide array of behavioral and physiological circadian rhythms. Affective disorders are typically associated with disruption of this fine-tuned "internal synchronization," but whether this internal misalignment is part of the physiopathology of mood disorders is not clear. To date, depressive-like behavior in animal models has been induced by methods that fail to specifically target the SCN regulation of internal synchronization as the mode to generate depression...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28075598/organocatalytic-regioselective-concomitant-thiocyanation-and-acylation-of-oxiranes-using-aroyl-isothiocyanates
#3
Anju Modi, Wajid Ali, Bhisma K Patel
A regioselective and concomitant transfer of thiocyanate (-SCN) and aroyl/acyl (-COR) groups from aroyl/acyl isothiocyanates onto oxiranes was achieved, giving thiocyanato benzoates in 100% atom economy. In this biomimetic organocatalytic process, one part (-SCN) of aroyl/acyl isothiocyanates acts as the nucleophile whereas the other half (-COR) serves as an electrophilic partner.
January 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28073911/a-truncated-g-csfr-inhibits-apoptosis-induced-by-neutrophil-elastase-g185r-mutant-implication-for-understanding-csf3r-mutations-in-severe-congenital-neutropenia
#4
Yaling Qiu, Yangyang Zhang, Nan Hu, Fan Dong
Mutations in ELANE encoding neutrophil elastase (NE) have been identified in the majority of patients with severe congenital neutropenia (SCN). The NE mutants have been shown to activate unfolded protein response (UPR) and induce premature apoptosis in myeloid cells. Patients with SCN are predisposed to acute myeloid leukemia (AML), and progression from SCN to AML is accompanied by mutations in CSF3R encoding the G-CSF receptor (G-CSFR) in approximately 80% patients. The mutations result in the expression of C-terminally truncated G-CSFRs that promote strong cell proliferation and survival...
January 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28068063/porous-iron-tungsten-carbide-electrocatalyst-with-high-activity-and-stability-toward-oxygen-reduction-reaction-from-the-self-assisted-synthetic-mechanism-to-its-active-species-probing
#5
Li Song, Tao Wang, Yilin Wang, Hairong Xue, Xiaoli Fan, Hu Guo, Wei Xia, Hao Gong, Jianping He
We synthesized a novel non-precious metal electrocatalyst by pyrolysis of a colloid mixture consisting of tungsten source and phenolic resin, with the simultaneous addition of ferric salt. The rationally designed electrocatalyst has a unique structure, with nano-sized WC and Fe3W3C uniformly dispersed in a three-dimensional porous carbon framework. WC, which was thought difficult to produce, is successfully prepared at a relatively low temperature of about 750 oC at inert atmosphere. XRD studies demonstrate the self-assisted effect of Fe, which accelerates the formation of WC, getting around the pathway of direct carbonaceous reduction of tungsten by carbon...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28065650/network-dynamics-mediate-circadian-clock-plasticity
#6
Abdelhalim Azzi, Jennifer A Evans, Tanya Leise, Jihwan Myung, Toru Takumi, Alec J Davidson, Steven A Brown
A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can change circadian period length through a mechanism requiring de novo DNA methylation. We show here that this mechanism is mediated not via cell-autonomous clock properties, but rather through altered networking within the suprachiasmatic nuclei (SCN), the circadian "master clock," which is DNA methylated in region-specific manner. DNA methylation is necessary to temporally reorganize circadian phasing among SCN neurons, which in turn changes the period length of the network as a whole...
January 2, 2017: Neuron
https://www.readbyqxmd.com/read/28064187/genetics-and-adaptation-of-soybean-cyst-nematode-to-broad-spectrum-soybean-resistance
#7
Michael Gardner, Robert Heinz, Jianying Wang, Melissa G Mitchum
The soybean cyst nematode (SCN) Heterodera glycines is a major threat to soybean production made more challenging by the current limitations of natural resistance for managing this pathogen. The use of resistant host cultivars is effective but over time results in the generation of virulent nematode populations able to robustly parasitize the resistant host. In order to understand how virulence develops in SCN we utilized a single backcrossed BC1F2 strategy to mate a highly virulent inbred population (TN20) capable of reproducing on all current sources of resistance with an avirulent one (PA3) unable to reproduce on any of the resistant soybean lines...
January 6, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28060778/two-dimensional-mo-scn-2-a-novel-mos2-variant
#8
Dimitrios Kaltsas, Leonidas Tsetseris
Transition metal dichalcogenides (TMDC) are currently among the most studied two-dimensional (2D) materials. Based on first-principles calculations we propose a new family of 2D materials which resemble TMDC's, but contain more complex chemical groups instead of elemental chalcogen atoms. In particular, we identify various stable 2D polymorphs of molybdenum di-thiocyanate, Mo(SCN)2, with structures akin to those of MoS2. The most stable Mo(SCN)2 polymorphs are semiconductors with small energy band gaps, whereas a higher-energy structure is metallic...
January 6, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28057567/prenatal-administration-of-letrozole-reduces-sdn-and-scn-volume-and-cell-number-independent-of-partner-preference-in-the-male-rat
#9
Sandra Olvera-Hernández, Miguel Tapia-Rodríguez, Dick F Swaab, Alonso Fernández-Guasti
During development, the exposure to testosterone, and its conversion to estradiol by an enzyme complex termed aromatase, appears to be essential in adult male rats for the expression of typical male sexual behavior and female-sex preference. Some hypothalamic areas are the supposed neural bases of sexual preference/orientation; for example, male-oriented rams have a reduced volume of the sexually dimorphic nucleus (oSDN), while in homosexual men this nucleus does not differ from that of heterosexual men. In contrast, homosexual men showed a larger number of vasopressinergic cells in the suprachiasmatic nucleus (SCN)...
January 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28057412/peripheral-administration-of-interleukin-13-reverses-inflammatory-macrophage-and-tactile-allodynia-in-mice-with-partial-sciatic-nerve-ligation
#10
Norikazu Kiguchi, Haruka Sakaguchi, Yui Kadowaki, Fumihiro Saika, Yohji Fukazawa, Shinsuke Matsuzaki, Shiroh Kishioka
Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1 was upregulated in accumulating macrophages in the injured SCN after PSL. Treatment with IL-13 reduced inflammatory macrophage-dominant molecules and increased suppressive macrophage-dominant molecules in cultured lipopolysaccharide-stimulated peritoneal macrophages and ex vivo SCN subjected to PSL...
December 23, 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28054487/guanidinium-can-both-cause-and-prevent-the-hydrophobic-collapse-of-biomacromolecules
#11
Jan Heyda, Halil I Okur, Jana Hladílková, Kelvin B Rembert, William Hunn, Tinglu Yang, Joachim Dzubiella, Pavel Jungwirth, Paul S Cremer
A combination of Fourier transform infrared and phase transition measurements as well as molecular computer simulations, and thermodynamic modeling were performed to probe the mechanisms by which guanidinium (Gnd(+)) salts influence the stability of the collapsed versus uncollapsed state of an elastin-like polypeptide (ELP), an uncharged thermoresponsive polymer. We found that the cation's action was highly dependent upon the counteranion with which it was paired. Specifically, Gnd(+) was depleted from the ELP/water interface and was found to stabilize the collapsed state of the macromolecule when paired with well-hydrated anions such as SO4(2-)...
January 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28052649/prognostic-impact-of-elective-supraclavicular-nodal-irradiation-for-patients-with-n1-breast-cancer-after-lumpectomy-and-anthracycline-plus-taxane-based-chemotherapy-krog-1418-a-multicenter-case-controlled-study
#12
Haeyoung Kim, Won Park, Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Yeon-Joo Kim, Eun Sook Lee, Keun Seok Lee, Han-Sung Kang, In Hae Park, Kyung Hwan Shin, Chan Woo Wee, Kyubo Kim, Kyung Ran Park, Yong Bae Kim, Sung Ja Ahn, Jong Hoon Lee, Jin Hee Kim, Mison Chun, Hyung-Sik Lee, Jung Soo Kim, Jihye Cha
Purpose: This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy. Materials and Methods: We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching...
January 4, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28049647/regulating-the-suprachiasmatic-nucleus-scn-circadian-clockwork-interplay-between-cell-autonomous-and-circuit-level-mechanisms
#13
REVIEW
Erik D Herzog, Tracey Hermanstyne, Nicola J Smyllie, Michael H Hastings
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous transcription-based clockwork but, in turn, circuit-level interactions synchronize the 20,000 or so SCN neurons into a robust and coherent daily timer. Synchronization requires neuropeptide signaling, regulated by a reciprocal interdependence between the molecular clockwork and rhythmic electrical activity, which in turn depends on a daytime Na(+) drive and nighttime K(+) drag...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28033724/identification-of-virulence-genes-carried-by-bacteriophages-obtained-from-clinically-isolated-methicillin-resistant-staphylococcus-aureus
#14
Djursun Karasartova, Zeynep Burcin Cavusoglu, Buse Turegun, Murat T Ozsan, Fikret Şahin
Bacteriophages play an important role in the pathogenicity of Staphylococcus aureus (S. aureus) either by carrying accessory virulence factors or several superantigens. Despite their importance, there are not many studies showing the actual distribution of the virulence genes carried by the prophages obtained from the clinically isolated Staphylococcus. In this study, we investigated prophages obtained from methicillin-resistant S. aureus (MRSA) strains isolated from hospital- and community-associated (HA-CA) infections for the virulence factors...
December 2016: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28033466/mixed-cation-thiocyanate-based-pseudohalide-perovskite-solar-cells-with-high-efficiency-and-stability
#15
Yu-Hsien Chiang, Ming-Hsien Li, Hsin-Min Cheng, Po-Shen Shen, Peter Chen
Novel organic-inorganic hybrid perovskite compounds composed of mixed A-site cation (Formamidinium and Cesium) and pseudohalides (SCN and I) ions are successfully synthesized. These new classes of hybrid perovskites photovoltaics exhibited remarkable power conversion efficiency of more than 16% with excellent stability against moisture in ambient environment and under low-light storage condition. The existence of SCN(-) ion inclusion is confirmed by secondary ion mass spectrometry and Fourier transform infrared spectroscopy...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28031289/attenuated-pupillary-light-responses-and-downregulation-of-opsin-expression-parallel-decline-in-circadian-disruption-in-two-different-mouse-models-of-huntington-s-disease
#16
Koliane Ouk, Steven Hughes, Carina A Pothecary, Stuart N Peirson, A Jennifer Morton
Circadian deficits in Huntington's disease (HD) are recapitulated in both fragment (R6/2) and full-length (Q175) mouse models of HD. Circadian rhythms are regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, which are primarily entrained by light detected by the retina. The SCN receives input from intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the photopigment melanopsin, but also receive input from rods and cones. In turn, ipRGCs mediate a range of non-image forming responses to light including circadian entrainment and the pupillary light response (PLR)...
December 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28017605/an-lhx1-regulated-transcriptional-network-controls-sleep-wake-coupling-and-thermal-resistance-of-the-central-circadian-clockworks
#17
Joseph L Bedont, Tara A LeGates, Ethan Buhr, Abhijith Bathini, Jonathan P Ling, Benjamin Bell, Mark N Wu, Philip C Wong, Russell N Van Gelder, Valerie Mongrain, Samer Hattar, Seth Blackshaw
The suprachiasmatic nucleus (SCN) is the central circadian clock in mammals. It is entrained by light but resistant to temperature shifts that entrain peripheral clocks [1-5]. The SCN expresses many functionally important neuropeptides, including vasoactive intestinal peptide (VIP), which drives light entrainment, synchrony, and amplitude of SCN cellular clocks and organizes circadian behavior [5-16]. The transcription factor LHX1 drives SCN Vip expression, and cellular desynchrony in Lhx1-deficient SCN largely results from Vip loss [17, 18]...
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28011880/roles-of-estrogen-receptor-alpha-in-mediating-lifespan-the-hypothalamic-deregulation-hypothesis
#18
Arvin M Gouw, Gizem Efe, Rita Barakat, Andrew Preecha, Movarid Mehdizadeh, Steven A Garan, George A Brooks
In several species caloric restriction (CR) extends lifespan. In this paper we integrate data from studies on CR and other sources to articulate the Hypothalamic Deregulation Hypothesis by which Estrogen Receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects lifespan under the stress of CR in mammals. ER-α is one of two principal estrogen-binding receptors differentially expressed in the amygdala, hippocampus, and several key hypothalamic nuclei: the Arcuate nucleus (ARN), Preoptic Area (POA), Ventromedial nucleus (VMN), Antero Ventral Periventricular Nucleus (AVPV), Paraventricular nucleus (PVN), Supraoptic nucleus (SON), and Suprachiasmatic nucleus (SCN)...
December 23, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/28006027/evidence-for-weakened-intercellular-coupling-in-the-mammalian-circadian-clock-under-long-photoperiod
#19
M Renate Buijink, Assaf Almog, Charlotte B Wit, Ori Roethler, Anneke H O Olde Engberink, Johanna H Meijer, Diego Garlaschelli, Jos H T Rohling, Stephan Michel
For animals living in temperate latitudes, seasonal changes in day length are an important cue for adaptations of their physiology and behavior to the altered environmental conditions. The suprachiasmatic nucleus (SCN) is known as the central circadian clock in mammals, but may also play an important role in adaptations to different photoperiods. The SCN receives direct light input from the retina and is able to encode day-length by approximating the waveform of the electrical activity rhythm to the duration of daylight...
2016: PloS One
https://www.readbyqxmd.com/read/28004075/regulation-of-reproduction-by-the-circadian-rhythms
#20
Wen-Xiang Zhang, Si-Yu Chen, Chang Liu
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in the environment. Circadian rhythm is controlled by the central clock in the hypothalamic suprachiasmatic nucleus (SCN) and the peripheral clocks in various tissues. More importantly, the central clock can integrate photic/nonphotic signals to generate rhythmic outputs, and then drive the slave oscillators in peripheral tissues through neuroendocrine and behavioral signals. Human reproductive activities, as some other physiological functions, are controlled by the biological clocks...
December 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
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