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https://www.readbyqxmd.com/read/28338077/characterization-of-the-soluble-nsf-attachment-protein-gene-family-identifies-two-members-involved-in-additive-resistance-to-a-plant-pathogen
#1
Naoufal Lakhssassi, Shiming Liu, Sadia Bekal, Zhou Zhou, Vincent Colantonio, Kris Lambert, Abdelali Barakat, Khalid Meksem
Proteins with Tetratricopeptide-repeat (TPR) domains are encoded by large gene families and distributed in all plant lineages. In this study, the Soluble NSF-Attachment Protein (SNAP) subfamily of TPR containing proteins is characterized. In soybean, five members constitute the SNAP gene family: GmSNAP18, GmSNAP11, GmSNAP14, GmSNAP02, and GmSNAP09. Recently, GmSNAP18 has been reported to mediate resistance to soybean cyst nematode (SCN). Using a population of recombinant inbred lines from resistant and susceptible parents, the divergence of the SNAP gene family is analysed over time...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331994/daily-socs1-rhythms-alter-with-aging-differentially-in-peripheral-clocks-in-male-wistar-rats-therapeutic-effects-of-melatonin
#2
Ch Vinod, Anita Jagota
Suprachiasmatic nucleus (SCN) in synchronization with the peripheral clocks regulates the temporal oscillations leading to overt rhythms. Aging leads to attenuation of such circadian regulation, accompanied by increased inflammatory mediators prevalently the cytokines. Suppressors of cytokine signaling (SOCS) family of proteins such as SOCS 1, 3 and cytokine-inducible SH2-containing protein (CIS) negatively regulate the cytokine signaling pathway. The role of SOCS1 in aging and circadian system is obscure. We therefore studied the daily rhythms of rSocs1 mRNA expression at Zeitgeber time (ZT) -0, 6, 12 and 18 in peripheral clocks such as liver, kidney, intestine and heart of 3, 12 and 24 months (m) old male Wistar rats...
March 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28330245/co-metabolism-of-thiocyanate-and-free-cyanide-by-exiguobacterium-acetylicum-and-bacillus-marisflavi-under-alkaline-conditions
#3
Lukhanyo Mekuto, Oluwadara Oluwaseun Alegbeleye, Seteno Karabo Obed Ntwampe, Maxwell Mewa Ngongang, John Baptist Mudumbi, Enoch A Akinpelu
The continuous discharge of cyanide-containing effluents to the environment has necessitated for the development of environmentally benign treatment processes that would result in complete detoxification of the cyanide-containing wastewaters, without producing additional environmental toxicants. Since biological detoxification of hazardous chemical compounds has been renowned for its robustness and environmental-friendliness, the ability of the Exiguobacterium acetylicum (GenBank accession number KT282229) and Bacillus marisflavi (GenBank accession number KR016603) to co-metabolise thiocyanate (SCN(-)) and free cyanide (CN(-)) under alkaline conditions was evaluated...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330076/free-cyanide-and-thiocyanate-biodegradation-by-pseudomonas-aeruginosa-stk-03-capable-of-heterotrophic-nitrification-under-alkaline-conditions
#4
Lukhanyo Mekuto, Seteno Karabo Obed Ntwampe, Margaret Kena, Mhlangabezi Tolbert Golela, Olusola Solomon Amodu
An alkali-tolerant bacterium, Pseudomonas aeruginosa STK 03 (accession number KR011154), isolated from an oil spill site, was evaluated for the biodegradation of free cyanide and thiocyanate under alkaline conditions. The organism had a free cyanide degradation efficiency of 80 and 32 % from an initial concentration of 250 and 450 mg CN(-)/L, respectively. Additionally, the organism was able to degrade thiocyanate, achieving a degradation efficiency of 78 and 98 % from non- and free cyanide spiked cultures, respectively...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28326909/resynchronization-dynamics-reveal-that-the-ventral-entrains-the-dorsal-suprachiasmatic-nucleus
#5
Stephanie R Taylor, Thomas J Wang, Daniel Granados-Fuentes, Erik D Herzog
Although the suprachiasmatic nucleus (SCN) has long been considered the master circadian clock in mammals, the topology of the connections that synchronize daily rhythms among SCN cells is not well understood. We combined experimental and computational methods to infer the directed interactions that mediate circadian synchrony between regions of the SCN. We analyzed PERIOD2 (PER2) expression from SCN slices during and after treatment with tetrodotoxin, allowing us to map connections as cells resynchronized their daily cycling following blockade and restoration of cell-cell communication...
February 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28326469/hsv-1-interaction-to-3-o-sulfated-heparan-sulfate-in-mouse-derived-drg-explant-and-profiles-of-inflammatory-markers-during-virus-infection
#6
Harsh Sharthiya, Chanmoly Seng, T H Van Kuppevelt, Vaibhav Tiwari, Michele Fornaro
The molecular mechanism of herpes simplex virus (HSV) entry and the associated inflammatory response in the nervous system remain poorly understood. Using mouse-derived ex vivo dorsal root ganglia (DRG) explant model and single cell neurons (SCNs), in this study, we provided a visual evidence for the expression of heparan sulfate (HS) and 3-O-sulfated heparan sulfate (3-OS HS) followed by their interactions with HSV-1 glycoprotein B (gB) and glycoprotein D (gD) during cell entry. Upon heparanase treatment of DRG-derived SCN, a significant inhibition of HSV-1 entry was observed suggesting the involvement of HS role during viral entry...
March 21, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28324017/a-novel-selective-bombesin-receptor-subtype-3-agonist-promotes-weight-loss-in-male-diet-induced-obese-rats-with-circadian-rhythm-change
#7
Yasunori Nio, Natsu Hotta, Minoru Maruyama, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shoki Okuda, Shizuo Kasai, Yugo Habata, Yasutaka Nagisa
Bombesin receptor subtype 3 (BRS-3) is an orphan G-protein-coupled receptor. Based on the obese phenotype of male BRS-3-deficient mice, BRS-3 has been considered an attractive target for obesity treatment. Here, we developed a novel selective BRS-3 agonist (Compound-A) and evaluated its anti-obesity effects. Compound-A showed anorectic effects and enhanced energy expenditure in diet-induced obese (DIO)-F344 rats. Moreover, repeated oral administration of Compound-A for 7 days resulted in a significant body weight reduction in DIO-F344 rats...
March 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28320839/sleep-deprivation-and-caffeine-treatment-potentiate-photic-resetting-of-the-master-circadian-clock-in-a-diurnal-rodent
#8
Pawan Kumar Jha, Hanan Bouâouda, Sylviane Gourmelen, Stephanie Dumont, Fanny Fuchs, Yannick Goumon, Patrice Bourgin, Andries Kalsbeek, Etienne Challet
Circadian rhythms in nocturnal and diurnal mammals are primarily synchronized to local time by the light-dark cycle. However, non-photic factors, such as behavioural arousal and metabolic cues, can also phase-shift the master clock in the suprachiasmatic nuclei (SCN) and/or reduce the synchronizing effects of light in nocturnal rodents. In diurnal rodents, the role of arousal or insufficient sleep in these functions is still poorly understood. In the present study, diurnal Sudanian grass rats, Arvicanthis ansorgei, were aroused at night by sleep deprivation (gentle handling) or caffeine treatment that both prevented sleep...
March 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28317996/rational-designed-strategy-to-dispel-mutual-interference-of-mercuric-and-ferric-ions-towards-robust-ph-stable-fluorescent-carbon-nanodots
#9
Yang Liu, Yanan Liu, Jinpyo Lee, Joong Hee Lee, Mira Park, Hak Yong Kim
As one of the most promising fluorometric nanosensors for metal ion sensing, carbon nanodots (C-dots) have developed rapidly in recent years. However, it is still a thorny problem to shield the mutual interference of two metal ions towards C-dots, e.g., Hg(2+) and Fe(3+) ions. In the present work, we propose rational routes for the unique interaction between C-dots and Hg(2+) or Fe(3+). The selectivity of the as-obtained label-free C-dots can be effectively switched by P3O10(5-) and SCN(-). The resultant C-dots possess superior photoluminescence intensity stability in a wide pH range or in certain redox circumstances, which are highly preferred in terms of practical metal-ion detection...
March 20, 2017: Analyst
https://www.readbyqxmd.com/read/28296412/negative-linear-compressibility-due-to-layer-sliding-in-a-layered-mof
#10
Qingxin Zeng, Kai Wang, Yuancun Qiao, Xiaodong Li, Bo Zou
Negative linear compressibility (NLC) is a rare and counterintuitive phenomenon because materials with this property would expand along one specific direction when uniformly compressed. NLC materials have a broad range of potential applications in designing pressure sensors, artificial muscles and so on. Designing and searching for systems with NLC is desired and crucial for material and compression science. Herein, with the help of high-pressure X-ray diffraction measurements and density functional theory calculations, we find that the 2D layered Co(SCN)2(pyrazine)2 exhibits NLC with a new mechanism-layer sliding...
March 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28290673/oxidations-at-sulfur-centers-by-aqueous-hypochlorous-acid-and-hypochlorite-cl-versus-o-atom-transfer
#11
Ying Hu, Guangyuan Xie, David M Stanbury
Sulfur-containing compounds are known to be susceptible to oxidation by aqueous HOCl, but the factors affecting the rates of these reactions are not well-established. Here we report on the kinetics of oxidation of thiosulfate, thiourea, thioglycolate, (methylthio)acetate, tetrathionate, dithiodiglycolate, and dithiodipropionate at 25 °C and 0.4 M ionic strength. These reactions obey the general rate law -d[OCl(-)]/dt = (kOCl(-)[OCl(-)] + kHOCl[HOCl])[substrate] with some exceptions: tetrathionate and the two disulfides undergo rate-limiting hydrolysis at high pH, and dithiodiglycolate has an additional term in the rate law that is second order in [substrate]...
March 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28288865/retinal-npy-and-5-ht-inputs-to-the-aged-suprachiasmatic-nucleus-in-common-marmosets-callithrix-jacchus
#12
Rovena C G J Engelberth, Kayo D de Azevedo Silva, Felipe Porto Fiuza, Joacil Germano Soares, Miriam S M O Costa, Ruthnaldo R de Melo Lima, Expedito Silva do Nascimento, José R Dos Santos, José R L P Cavalcanti, Jeferson S Cavalcante
The circadian timing system (CTS) anticipates optimal physiological patterns in response to environmental fluctuations, such as light-dark cycle. Since age-related disruption of circadian synchronization is linked to several pathological conditions, we characterized alterations of neurochemical constituents and retinal projections to the major pacemaker of CTS, the suprachiasmatic nucleus (SCN), in adult and aged marmosets. We used intraocular injections of neural tracer Cholera toxin b (CTb) to report age-related reductions in CTb, neuropeptide Y and serotonin immunoreactivities...
March 10, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28286126/circadian-rhythms-of-hedonic-drinking-behavior-in-mice
#13
Claire Bainier, Maria Mateo, Marie-Paule Felder-Schmittbuhl, Jorge Mendoza
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the main circadian clock, synchronized by the light-dark cycle, which generates behavioral rhythms like feeding, drinking and activity. Notwithstanding, the main role of the SCN clock on the control of all circadian rhythms has been questioned due to the presence of clock activity in many brain areas, including those implicated in the regulation of feeding and reward. Moreover, whether circadian rhythms of particular motivated behaviors exist is unknown...
March 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28285822/astrocytes-control-circadian-timekeeping-in-the-suprachiasmatic-nucleus-via-glutamatergic-signaling
#14
Marco Brancaccio, Andrew P Patton, Johanna E Chesham, Elizabeth S Maywood, Michael H Hastings
The suprachiasmatic nucleus (SCN) of the hypothalamus orchestrates daily rhythms of physiology and behavior in mammals. Its circadian (∼24 hr) oscillations of gene expression and electrical activity are generated intrinsically and can persist indefinitely in temporal isolation. This robust and resilient timekeeping is generally regarded as a product of the intrinsic connectivity of its neurons. Here we show that neurons constitute only one "half" of the SCN clock, the one metabolically active during circadian daytime...
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28283923/characterization-of-staphylococcus-aureus-in-goose-feces-from-state-parks-in-northeast-ohio
#15
Dipendra Thapaliya, Mark Dalman, Jhalka Kadariya, Katie Little, Victoria Mansell, Mohammed Y Taha, Dylan Grenier, Tara C Smith
Staphylococcus aureus can colonize a range of species. Although numerous studies have isolated pathogenic bacteria from wild birds, very little is known regarding S. aureus and their potential to spread methicillin-resistant (MRSA) strains. The objective of this study was to determine the presence and molecular characteristics of S. aureus in geese fecal samples collected from ten state parks across Northeast Ohio (NEO). A total of 182 fecal samples from Canada geese (Branta canadensis) were collected in April 2015...
March 10, 2017: EcoHealth
https://www.readbyqxmd.com/read/28270612/synchronous-circadian-voltage-rhythms-with-asynchronous-calcium-rhythms-in-the-suprachiasmatic-nucleus
#16
Ryosuke Enoki, Yoshiaki Oda, Michihiro Mieda, Daisuke Ono, Sato Honma, Ken-Ichi Honma
The suprachiasmatic nucleus (SCN), the master circadian clock, contains a network composed of multiple types of neurons which are thought to form a hierarchical and multioscillator system. The molecular clock machinery in SCN neurons drives membrane excitability and sends time cue signals to various brain regions and peripheral organs. However, how and at what time of the day these neurons transmit output signals remain largely unknown. Here, we successfully visualized circadian voltage rhythms optically for many days using a genetically encoded voltage sensor, ArcLightD...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28264977/constant-light-desynchronises-olfactory-versus-object-and-visuospatial-recognition-memory-performance
#17
Shu K E Tam, Sibah Hasan, Harry M C Choi, Laurence A Brown, Aarti Jagannath, Steven Hughes, Mark W Hankins, Russell G Foster, Vladyslav V Vyazovskiy, David M Bannerman, Stuart N Peirson
Circadian rhythms optimise physiology and behaviour to the varying demands of the 24-hour day. The master circadian clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and it regulates circadian oscillators in tissues throughout the body to prevent internal desynchrony. Here we demonstrate for the first time that, under standard 12-h:12-h light--dark cycles (LD), object, visuospatial, and olfactory recognition performance in C57BL/6J mice is consistently better at midday relative to midnight...
March 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28261043/the-role-of-circadian-rhythms-in-muscular-and-osseous-physiology-and-their-regulation-by-nutrition-and-exercise
#18
REVIEW
Shinya Aoyama, Shigenobu Shibata
The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28250270/an-activatable-fluorescent-%C3%AE-polyglutamic-acid-complex-for-sentinel-lymph-node-imaging
#19
Masayori Hagimori, Eri Hatabe, Kohei Sano, Hirotaka Miyazaki, Hitoshi Sasaki, Hideo Saji, Takahiro Mukai
Sentinel lymph nodes (SLN) are the first lymph nodes (LN) where cancer cells metastasize from the primary tumor. We designed fluorophore-quencher-based activatable nanoparticles for SLN imaging. We selected TAMRA as a fluorophore and BHQ2 or QSY7 as a quencher. Ternary anionic complexes were constructed with generation 4th polyamidoamine dendrimer (G4) modified with TAMRA and p-SCN-Bn-DTPA (DTPA), polyethyleneimine (PEI) modified with BHQ2 or QSY7, and γ-polyglutamic acid (γ-PGA) by the electrostatic self-assembly system...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28249777/analyses-of-the-cellular-clock-gene-expression-in-peripheral-tissue-caudal-fin-in-the-japanese-flounder-paralichthys-olivaceus
#20
Makoto Mogi, Hayato Yokoi, Tohru Suzuki
Understanding the systems for maintaining the circadian rhythms that give organisms the flexibility to adapt to environmental changes is important in both aquaculture and fish chronobiology, because nursery lighting conditions can affect the survival and growth rates of larvae. We previously demonstrated that in flounder, the suprachiasmatic nucleus (SCN) exhibits daily rhythm in per2 expression, in sharp contrast to zebrafish, in which the SCN does not exhibit clear per2 expression rhythm. To examine whether a hierarchy exists in systems that maintain the expression rhythm of peripheral clock genes in flounder, in the present study we analyzed the in vivo and in vitro expression of three clock genes, per2, per1, and cry1, in the caudal fin and the effects of cortisol and melatonin administration on the expression of each clock gene...
March 1, 2017: General and Comparative Endocrinology
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