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https://www.readbyqxmd.com/read/28723798/the-safety-and-effectiveness-of-robot-assisted-versus-laparoscopic-tme-in-patients-with-rectal-cancer-a-meta-analysis-and-systematic-review
#1
Xiaofei Li, Tao Wang, Liang Yao, Lidong Hu, Penghui Jin, Tiankang Guo, Kehu Yang
BACKGROUND: The aim of this study was to assess the safety and effectiveness of robotic-assisted versus laparoscopic total mesorectal excision (TME) in patients with rectal cancer. METHODS: We systematically searched PubMed, EMBASE, Cochrane library, Web of science, and Chinese Biomedical Literature Database up to July 2016 to identify case-controlled studies that compared robotic TME (RTME) with laparoscopic TME (LTME) for rectal cancer. GRADE was used to interpret the primary outcomes of this meta-analysis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28721807/developing-the-transdisciplinary-aging-research-agenda-new-developments-in-big-data
#2
Christian William Callaghan
In light of dramatic advances in big data analytics and the application of these advances in certain scientific fields, new potentialities exist for breakthroughs in aging research. Translating these new potentialities to research outcomes for aging populations, however, remains a challenge, as underlying technologies which have enabled exponential increases in 'big data' have not yet enabled a commensurate era of 'big knowledge,' or similarly exponential increases in biomedical breakthroughs. Debates also reveal differences in the literature, with some arguing big data analytics heralds a new era associated with the 'end of theory' or which makes the scientific method obsolete, where correlation supercedes causation, whereby science can advance without theory and hypotheses testing...
July 19, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28715939/surgical-versus-non-operative-treatment-for-lumbar-disc-herniation-a-systematic-review-and-meta-analysis
#3
Bing-Lin Chen, Jia-Bao Guo, Hong-Wei Zhang, Ya-Jun Zhang, Yi Zhu, Juan Zhang, Hao-Yu Hu, Yi-Li Zheng, Xue-Qiang Wang
OBJECTIVE: To investigate the effects of surgical versus non-operative treatment on the physical function and safety of patients with lumbar disc herniation. DATA SOURCES: PubMed, Cochrane Library, Embase, EBSCO, Web of Science, China National Knowledge Infrastructure and Chinese Biomedical Literature Database were searched from initiation to 15 May 2017. METHODS: Randomized controlled trials that evaluated surgical versus non-operative treatment for patients with lumbar disc herniation were selected...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28715701/synthetic-biological-approaches-to-optogenetically-control-cell-signaling
#4
REVIEW
Katja Kolar, Wilfried Weber
Precise spatial and temporal control of cellular processes is in life sciences a highly sought-after capability. In the recent years, this goal has become progressively achievable through the field of optogenetics, which utilizes light as a non-invasive means to control genetically encoded light-responsive proteins. The latest optogenetic systems, such as those for control of subcellular localization or cellular decision-making and tissue morphogenesis provide us with insights to gain a deeper understanding of the cellular inner workings...
July 14, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28715407/building-the-biomedical-data-science-workforce
#5
Michelle C Dunn, Philip E Bourne
This article describes efforts at the National Institutes of Health (NIH) from 2013 to 2016 to train a national workforce in biomedical data science. We provide an analysis of the Big Data to Knowledge (BD2K) training program strengths and weaknesses with an eye toward future directions aimed at any funder and potential funding recipient worldwide. The focus is on extramurally funded programs that have a national or international impact rather than the training of NIH staff, which was addressed by the NIH's internal Data Science Workforce Development Center...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28713181/neophilia-ranking-of-scientific-journals
#6
Mikko Packalen, Jay Bhattacharya
The ranking of scientific journals is important because of the signal it sends to scientists about what is considered most vital for scientific progress. Existing ranking systems focus on measuring the influence of a scientific paper (citations)-these rankings do not reward journals for publishing innovative work that builds on new ideas. We propose an alternative ranking based on the proclivity of journals to publish papers that build on new ideas, and we implement this ranking via a text-based analysis of all published biomedical papers dating back to 1946...
January 2017: Scientometrics
https://www.readbyqxmd.com/read/28713128/introduction-community-academic-partnerships-in-research-and-public-health
#7
Emily E Anderson, Kevin J Valadares
This symposium includes twelve personal narratives from individuals and teams who have been engaged in community-academic partnerships in research and public health. This issue also includes four commentaries on these narratives by experts in patient and research subject advocacy, healthcare and biomedical ethics, social science, and health education funding. While much has been written about community-academic partnerships, what appears in the literature does not include in-depth, personal reflection on the challenges and obstacles faced in these partnerships...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/28712062/genome-editing-and-genetic-engineering-in-livestock-for-advancing-agricultural-and-biomedical-applications
#8
Bhanu P Telugu, Ki-Eun Park, Chi-Hun Park
Genetic modification of livestock has a longstanding and successful history, starting with domestication several thousand years ago. Modern animal breeding strategies predominantly based on marker-assisted and genomic selection, artificial insemination, and embryo transfer have led to significant improvement in the performance of domestic animals, and are the basis for regular supply of high quality animal derived food. However, the current strategy of breeding animals over multiple generations to introduce novel traits is not realistic in responding to the unprecedented challenges such as changing climate, pandemic diseases, and feeding an anticipated 3 billion increase in global population in the next three decades...
July 15, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28706616/is-there-any-association-between-glutathione-s-transferases-m1-and-glutathione-s-transferases-t1-gene-polymorphisms-and-endometrial-cancer-risk-a-meta-analysis
#9
REVIEW
Xiuxiu Yin, Jie Chen
Epidemiological evidence on the association between genetic polymorphisms in glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes and risk of endometrial cancer (EC) has been inconsistent. In this meta-analysis, we seek to investigate the relationship between GSTM1 and GSTT1 polymorphisms and the risk of EC. We searched Medline, PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure database, and Chinese Biomedical Literature database to identify eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) for the association were determined using a fixed- or random-effect model...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28706080/power-up-a-reanalysis-of-power-failure-in-neuroscience-using-mixture-modelling
#10
Camilla L Nord, Vincent Valton, John Wood, Jonathan P Roiser
Evidence for endemically low statistical power has recently cast neuroscience findings into doubt. If low statistical power plagues neuroscience, this reduces confidence in reported effects. However, if statistical power is not uniformly low, such blanket mistrust might not be warranted. Here, we provide a different perspective on this issue, analysing data from an influential paper reporting a median power of 21% across 49 meta-analyses (Button et al., 2013). We demonstrate, using Gaussian mixture modelling, that the sample of 730 studies included in that analysis comprises several subcomponents; therefore the use of a single summary statistic is insufficient to characterise the nature of the distribution...
July 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28705870/on-the-promotion-of-human-flourishing
#11
Tyler J VanderWeele
Many empirical studies throughout the social and biomedical sciences focus only on very narrow outcomes such as income, or a single specific disease state, or a measure of positive affect. Human well-being or flourishing, however, consists in a much broader range of states and outcomes, certainly including mental and physical health, but also encompassing happiness and life satisfaction, meaning and purpose, character and virtue, and close social relationships. The empirical literature from longitudinal, experimental, and quasiexperimental studies is reviewed in attempt to identify major determinants of human flourishing, broadly conceived...
July 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28705729/nanomedicine-and-epigenome-possible-health-risks
#12
Bozena Smolkova, Maria Dusinska, Alena Gabelova
Nanomedicine is an emerging field that combines knowledge of nanotechnology and material science with pharmaceutical and biomedical sciences, aiming to develop nanodrugs with increased efficacy and safety. Compared to conventional therapeutics, nanodrugs manifest higher stability and circulation time, reduced toxicity and improved targeted delivery. Despite the obvious benefit, the accumulation of imaging agents and nanocarriers in the body following their therapeutic or diagnostic application generates concerns about their safety for human health...
July 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28703260/-publish-amp-perish-research-on-research-and-researchers
#13
J K Tijdink
In the last years many people have questioned the reliability of research results and the societal relevance of much of today's clinical research; they are critical too about the current publication culture in which scientists are judged according to the number of articles they have published, impact factors and citations.<br/> AIM: To make a close study of the publication culture that now prevails in the Dutch biomedical sciences. <br/> METHOD: Discussion of results described in the thesis entitled 'Publish and Perish; research on research and researchers'...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28699364/assistive-technologies-to-address-capabilities-of-people-with-dementia-from-research-to-practice
#14
Paul-Ariel Kenigsberg, Jean-Pierre Aquino, Alain Bérard, François Brémond, Kevin Charras, Tom Dening, Rose-Marie Droës, Fabrice Gzil, Ben Hicks, Anthea Innes, Mai Nguyen, Louise Nygård, Maribel Pino, Guillaume Sacco, Eric Salmon, Henriëtte van der Roest, Hervé Villet, Marion Villez, Philippe Robert, Valeria Manera
Assistive technologies became pervasive and virtually present in all our life domains. They can be either an enabler or an obstacle leading to social exclusion. The Fondation Médéric Alzheimer gathered international experts of dementia care, with backgrounds in biomedical, human and social sciences, to analyze how assistive technologies can address the capabilities of people with dementia, on the basis of their needs. Discussion covered the unmet needs of people with dementia, the domains of daily life activities where assistive technologies can provide help to people with dementia, the enabling and empowering impact of technology to improve their safety and wellbeing, barriers and limits of use, technology assessment, ethical and legal issues...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28697977/potential-biomedical-applications-of-marine-algae
#15
REVIEW
Hui-Min David Wang, Xiao-Chun Li, Duu-Jong Lee, Jo-Shu Chang
Functional components extracted from algal biomass are widely used as dietary and health supplements with a variety of applications in food science and technology. In contrast, the applications of algae in dermal-related products have received much less attention, despite that algae also possess high potential for the uses in anti-infection, anti-aging, skin-whitening, and skin tumor treatments. This review, therefore, focuses on integrating studies on algae pertinent to human skin care, health and therapy...
June 3, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28696524/molecular-hyperthermia-spatiotemporal-protein-unfolding-and-inactivation-by-nanosecond-plasmonic-heating
#16
Peiyuan Kang, Zhuo Chen, Steven O Nielsen, Kenneth Hoyt, Sheena D'Arcy, Jeremiah J Gassensmith, Zhenpeng Qin
Spatiotemporal control of protein structure and activity in biological systems has important and broad implications in biomedical sciences as evidenced by recent advances in optogenetic approaches. Here, this study demonstrates that nanosecond pulsed laser heating of gold nanoparticles (GNP) leads to an ultrahigh and ultrashort temperature increase, coined as "molecular hyperthermia", which causes selective unfolding and inactivation of proteins adjacent to the GNP. Protein inactivation is highly dependent on both laser pulse energy and GNP size, and has a well-defined impact zone in the nanometer scale...
July 11, 2017: Small
https://www.readbyqxmd.com/read/28692287/quantifying-the-structure-and-composition-of-flocculated-suspended-particulate-matter-using-focused-ion-beam-nanotomography
#17
Jonathan A T Wheatland, Andrew J Bushby, Kate L Spencer
Suspended particulate matter (SPM) is present in the natural aquatic environment as loosely bound aggregates or 'flocs' and is responsible for the transport and fate of sediment, carbon, nutrients, pollutants, pathogens and manufactured nanoparticles from catchment to coast. Accurate prediction of SPM hydrodynamics requires the quantification of 3D floc properties (size, shape, density and porosity) that span several spatial scales. Yet, current techniques (video camera systems, optical microscopy and transmission electron microscopy, TEM) can only provide 2D simplifications of size and shape with a spatial resolution gap between the 'gross' (>100s µm) and nano-scale (<1 µm)...
July 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28691535/promoting-free-flow-in-the-networks-reimagining-the-body-in-early-modern-suzhou
#18
Volker Scheid
The history of Chinese medicine is still widely imagined in terms dictated by the discourse of modernity, that is as 'traditional' and 'Chinese.' And yet, so as to be intelligible to us moderns, it must simultaneously be framed through categories that make it comparable somehow to the 'West' and the 'modern' from which it is said to be essentially different. This is accomplished, for instance, by viewing Chinese medicine as fundamentally shaped by cosmological thinking, as focusing on process rather than matter, and as forever hampered by attachments to the past even when it tries to innovate...
June 1, 2017: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28686557/the-biopsychosocial-model-40-years-of-application-in-psychiatry
#19
G Papadimitriou
In 1977, the American pathologist and psychiatrist George Engel (1913-1999) published in the Journal Science his paper "TheIn 1977, the American pathologist and psychiatrist George Engel (1913-1999) published in the Journal Science his paper "Theneed for a new medical model: A challenge for biomedicine", introducing the term Biopsychosocial Model. This model basedon the results of Engel's studies in ulcerative colitis, depression and psychogenic pain, constituted a challenge for biomedicineand the biomedical model...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28683540/composition-tunable-optical-properties-of-zn-x-cd-1%C3%A2-%C3%A2-x-s-quantum-dot-carboxymethylcellulose-conjugates-towards-one-pot-green-synthesis-of-multifunctional-nanoplatforms-for-biomedical-and-environmental-applications
#20
Alexandra A P Mansur, Herman S Mansur, Anderson J Caires, Rafael L Mansur, Luiz C Oliveira
Quantum dots (QDs) are colloidal semiconductor nanocrystals with unique properties that can be engineered by controlling the nanoparticle size and chemical composition by doping and alloying strategies. However, due to their potential toxicity, augmenting their biocompatibility is yet a challenge for expanding to several biomedical and environmentally friendly applications. Thus, the main goal of this study was to develop composition-tunable and biocompatible Zn x Cd1 - x S QDs using carboxymethylcellulose polysaccharide as direct capping ligand via green colloidal aqueous route at neutral pH and at room temperature for potential biomedical and environmental applications...
December 2017: Nanoscale Research Letters
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