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Biomedical science

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https://www.readbyqxmd.com/read/28227469/building-a-more-diverse-biomedical-engineering-workforce-biomedical-engineering-at-the-university-of-the-district-of-columbia-a-historically-black-college-university
#1
Lara A Thompson, A Segun Adebayo, Nian Zhang, Sasan Haghani, Kathleen Dowell, Devdas Shetty, Lara A Thompson, A Segun Adebayo, Nian Zhang, Sasan Haghani, Kathleen Dowell, Devdas Shetty, A Segun Adebayo, Sasan Haghani, Kathleen Dowell, Lara A Thompson, Devdas Shetty, Nian Zhang
Biomedical Engineering (BME) is a new, multidisciplinary, and rapidly growing field, however, the BME Workforce suffers from limited ethnic and gender diversity. Despite the demand and growth of this new field due to its public health importance, only 4 out of the 107 Historically Black Colleges and Universities (HBCUs) nationwide offers a Bachelor's of Science (B.S.) in Bio-Engineering related fields. In order to contribute to a growing BME Workforce, HBCUs need to react and offer more degree-programs relevant to BME...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227152/designing-a-hands-on-brain-computer-interface-laboratory-course
#2
Bahar Khalighinejad, Laura Kathleen Long, Nima Mesgarani, Bahar Khalighinejad, Laura Kathleen Long, Nima Mesgarani, Bahar Khalighinejad, Laura Kathleen Long, Nima Mesgarani
Devices and systems that interact with the brain have become a growing field of research and development in recent years. Engineering students are well positioned to contribute to both hardware development and signal analysis techniques in this field. However, this area has been left out of most engineering curricula. We developed an electroencephalography (EEG) based brain computer interface (BCI) laboratory course to educate students through hands-on experiments. The course is offered jointly by the Biomedical Engineering, Electrical Engineering, and Computer Science Departments of Columbia University in the City of New York and is open to senior undergraduate and graduate students...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226531/bayesian-deconvolution-of-scanning-electron-microscopy-images-using-point-spread-function-estimation-and-non-local-regularization
#3
Joris Roels, Jan Aelterman, Jonas De Vylder, Hiep Luong, Yvan Saeys, Wilfried Philips, Joris Roels, Jan Aelterman, Jonas De Vylder, Hiep Luong, Yvan Saeys, Wilfried Philips, Hiep Luong, Wilfried Philips, Jan Aelterman, Jonas De Vylder, Yvan Saeys, Joris Roels
Microscopy is one of the most essential imaging techniques in life sciences. High-quality images are required in order to solve (potentially life-saving) biomedical research problems. Many microscopy techniques do not achieve sufficient resolution for these purposes, being limited by physical diffraction and hardware deficiencies. Electron microscopy addresses optical diffraction by measuring emitted or transmitted electrons instead of photons, yielding nanometer resolution. Despite pushing back the diffraction limit, blur should still be taken into account because of practical hardware imperfections and remaining electron diffraction...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225839/-conceptual-and-methodological-issues-involved-in-the-research-field-of-diagnostic-reasoning
#4
Francisco N Di Persia
The psychopathological field is crossed by dilemmas that put in question its methodological, conceptual and philosophical filiations. Since the early works of Ey and Jaspers until recent work of Berrios it has been in question the position psychopathology has in the field of medicine in general, and in the field of psychiatry in particular, especially if it should follow the principles of natural science or if it has an autonomous position between them. This debate has led to two opposing positions facing two different models of psychopathology: the biomedical model and the socio-constructionist model...
May 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28222709/combined-application-versus-topical-and-intravenous-application-of-tranexamic-acid-following-primary-total-hip-arthroplasty-a-meta-analysis
#5
Pei Zhang, Yuan Liang, Pengtao Chen, Yongchao Fang, Jinshan He, Jingcheng Wang
BACKGROUND: The use of intravenous (IV) or topical tranexamic acid (TXA) in total hip arthroplasty has been proven to be effective and safe in total hip arthroplasty. However, which of these two administration routes is better has not been determined. The combined administration of TXA has been used in total knee arthroplasty with satisfactory results. We hypothesized that combined application of TXA may be the most effective way without increased rate of thrombotic events such as deep vein thrombosis (DVT) and pulmonary embolisms (PE) in patients subjected to primary total hip replacement (THA)...
February 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28220145/where-sepsis-and-antimicrobial-resistance-countermeasures-converge
#6
Timothy J J Inglis, Nadia Urosevic
The United Nations General Assembly debate on antimicrobial resistance (AMR) recognizes the global significance of AMR. Much work needs to be done on technology capability and capacity to convert the strategic intent of the debate into operational plans and tangible outcomes. Enhancement of the biomedical science-clinician interface requires better exploitation of systems biology tools for in-laboratory and point of care methods that detect sepsis and characterize AMR. These need to link sepsis and AMR data with responsive, real-time surveillance...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28219375/state-of-the-art-in-anti-cancer-mabs
#7
REVIEW
S M Chiavenna, J P Jaworski, A Vendrell
Following Milstein's discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making of them a therapeutic option for many cancer types in the current clinical practice. Today, mAbs are being developed to target different molecules with different mechanisms of action and its target potential is unlimited. However, this huge and fast growing new field needs to be organized to better understand the treatment options we have to confront different cancer diseases...
February 20, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28216260/optimal-expression-of-a-fab-effector-fusion-protein-in-escherichia-coli-by-removing-the-cysteine-residues-responsible-for-an-interchain-disulfide-bond-of-a-fab-molecule
#8
Hyeon-Ju Kang, Hye-Jin Kim, Mun-Sik Jung, Jae-Kyu Han, Sang-Hoon Cha
Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to the lack of proper chaperone proteins and an inappropriate physicochemical environment intrinsic to the microbial hosts. We previously reported that a human Fab molecule, referred to as SL335, reactive to human serum albumin has a prolonged in vivo serum half-life in rats...
February 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28214993/scaleus-semantic-web-services-integration-for-biomedical-applications
#9
Pedro Sernadela, Lorena González-Castro, José Luís Oliveira
In recent years, we have witnessed an explosion of biological data resulting largely from the demands of life science research. The vast majority of these data are freely available via diverse bioinformatics platforms, including relational databases and conventional keyword search applications. This type of approach has achieved great results in the last few years, but proved to be unfeasible when information needs to be combined or shared among different and scattered sources. During recent years, many of these data distribution challenges have been solved with the adoption of semantic web...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28208801/atomic-force-microscopy-a-powerful-tool-to-address-scaffold-design-in-tissue-engineering
#10
Marica Marrese, Vincenzo Guarino, Luigi Ambrosio
Functional polymers currently represent a basic component of a large range of biological and biomedical applications including molecular release, tissue engineering, bio-sensing and medical imaging. Advancements in these fields are driven by the use of a wide set of biodegradable polymers with controlled physical and bio-interactive properties. In this context, microscopy techniques such as Atomic Force Microscopy (AFM) are emerging as fundamental tools to deeply investigate morphology and structural properties at micro and sub-micrometric scale, in order to evaluate the in time relationship between physicochemical properties of biomaterials and biological response...
February 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28206852/british-journal-of-biomedical-science-in-2016-what-have-we-learned
#11
Andrew Blann
In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities...
January 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28205401/computer-aided-drug-design-to-explore-cyclodextrin-therapeutics-and-biomedical-applications
#12
Azizeh Abdolmaleki, Fatemeh Ghasemi, Jahan B Ghasemi
Cyclodextrin (CD) is a subset of the macrocyclic structural class, which is an important class of small organic agents that are useful functional excipients. They have wide range application possibilities in different fields of sciences such as material preparation, medicine, analytical chemistry, and separation processes. They are used widely in pharmaceutical formulations and drug delivery for increasing the water solubility of low soluble drugs and drug candidates. Due to the ring structure, they behave differently than smaller molecules and may be capable of hitting new classes of targets...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28194338/development-of-medical-writing-in-india-past-present-and-future
#13
REVIEW
Suhasini Sharma
Pharmaceutical medical writing has grown significantly in India in the last couple of decades. It includes preparing regulatory, safety, and publication documents as well as educational and communication material related to health and health-care products. Medical writing requires medical understanding, knowledge of drug development and the regulatory and safety domains, understanding of research methodologies, and awareness of relevant regulations and guidelines. It also requires the ability to analyze, interpret, and present biomedical scientific data in the required format and good writing skills...
January 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28193247/efficacy-and-safety-of-calcineurin-inhibitor-treatment-for-iga-nephropathy-a-meta-analysis
#14
Yu-Huan Song, Guang-Yan Cai, Yue-Fei Xiao, Yi-Ping Wang, Bao-Shi Yuan, Yuan-Yuan Xia, Si-Yang Wang, Pu Chen, Shu-Wen Liu, Xiang-Mei Chen
BACKGROUND: IgA nephropathy is the most common progressive glomerular disease to end stage renal failure worldwide. Calcineurin inhibitors (CNIs) is a selective immunosuppressant widely used in organ transplantation. The efficacy and safety of calcineurin inhibitors for the treatment of IgA nephropathy remain uncertain. METHODS: We performed a systematic literature search using the PubMed, Embase, Science Citation Index, Ovid evidence-based medicine, Chinese Biomedical Literature (CBM) and Chinese science and technology periodicals (CNKI, VIP, and Wan Fang) for randomized, controlled trials of CNIs therapy of IgA nephropathy...
February 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28192672/smart-nanostructures-for-cargo-delivery-uncaging-and-activating-by-light
#15
Mahdi Karimi, Parham Sahandi Zangabad, Soodeh Baghaee-Ravari, Mahdi Ghazizadeh, Hamed Mirshekari, Michael R Hamblin
Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, etc. Among drug delivery systems (DDSs), smart nanocarriers that can respond to specific stimuli in their local environment represent a growing field. Nanoplatforms that can be activated by an external application of light, can be used for a wide variety of photo-activated therapies, (especially light-triggered DDSs) relying on photo-isomerization, photo-crosslinking/uncrosslinking, photo-reduction, etc...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28191582/twisting-microfluidics-in-a-planetary-centrifuge
#16
Shoya Yasuda, Masayuki Hayakawa, Hiroaki Onoe, Masahiro Takinoue
This paper reports a twisting microfluidic method utilising a centrifuge-based fluid extruding system in a planetary centrifuge which simultaneously generates an orbital rotation and an axial spin. In this method, fluid extrusion from a micro-scale capillary to an 'open-space' solution or air enables release of the fluid from the capillary-based microchannel, which physically means that there is a release of fluids from a confined low-Reynolds-number environment to an open non-low-Reynolds-number environment...
February 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/28190696/ethical-issues-in-research
#17
REVIEW
Raul Artal, Sheldon Rubenfeld
Biomedical research is currently guided by ethical standards that have evolved over many centuries. Historical and political events, social and legal considerations, and continuous medical and technological advances have led to the prevailing research ethics and practice. Currently, patients and research subjects have complete autonomy while under medical care or when volunteering as research subjects. Enrolling volunteers in human subjects research includes a detailed and meaningful informed consent process that follows the cardinal principles of ethics: autonomy, beneficence, nonmaleficence, and justice...
January 23, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28188201/a-day-of-immersive-physiology-experiments-increases-knowledge-and-excitement-towards-physiology-and-scientific-careers-in-native-american-students
#18
Bryan K Becker, Alicia M Schiller, Irving H Zucker, Eric A Eager, Liliana P Bronner, Maurice Godfrey
Underserved minority groups are disproportionately absent from the pursuit of careers in science, technology, engineering, and mathematics (STEM) fields. One such underserved population, Native Americans, are particularly underrepresented in STEM fields. Although recent advocacy and outreach designed toward increasing minority involvement in health care-related occupations have been mostly successful, little is known about the efficacy of outreach programs in increasing minority enthusiasm toward careers in traditional scientific professions...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28187426/clustering-of-biological-datasets-in-the-era-of-big-data
#19
Richard Röttger
Clustering is a long-standing problem in computer science and is applied in virtually any scientific field for exploring the inherent structure of datasets. In biomedical research, clustering tools have been utilized in manifold areas, among many others in expression analysis, disease subtyping or protein research. A plethora of different approaches have been developed but there is only little guideline what approach is the optimal in what particular situation. Furthermore, a typical cluster analysis is an entire process with several highly interconnected steps; from preprocessing, proximity calculation, the actual clustering to evaluation and optimization...
December 22, 2016: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28182632/clinical-outcomes-of-patients-with-and-without-diabetes-mellitus-after-hepatectomy-a-systematic-review-and-meta-analysis
#20
Qingshan Li, Yue Wang, Tao Ma, Yi Lv, Rongqian Wu
BACKGROUND: Clinical data regarding the influence of diabetes mellitus (DM) on the outcomes of patients undergoing hepatectomy are conflicting. To determine the impact of DM on the clinical outcomes of patients undergoing hepatectomy, we systematically reviewed published studies and carried out a meta-analysis. METHODS: A systematic literature search of Pubmed, Sciencedirect, Web of Science, and Chinese Biomedical Database was conducted from their inception through February 2, 2016...
2017: PloS One
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