K Horvath, K Jeitler, A Berghold, S H Ebrahim, T W Gratzer, J Plank, T Kaiser, T R Pieber, A Siebenhofer
BACKGROUND: Despite indications from epidemiological trials that higher blood glucose concentrations are associated with a higher risk for developing micro- and macrovascular complications, evidence for a beneficial effect of antihyperglycaemic therapy in patients with type 2 diabetes mellitus is conflicting. Two large studies, the United Kingdom Prospective Diabetes Study (UKPDS) and the University Group Diabetes Program (UGDP), did not find a reduction of cardiovascular endpoints through improvement of metabolic control...
April 18, 2007: Cochrane Database of Systematic Reviews