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https://www.readbyqxmd.com/read/29305518/her2-is-frequently-overexpressed-in-hepatoid-adenocarcinoma-and-gastric-carcinoma-with-enteroblastic-differentiation-a-comparison-of-35-cases-to-334-gastric-carcinomas-of-other-histological-types
#1
Masakazu Fujimoto, Ibu Matsuzaki, Masaru Nishino, Yoshifumi Iwahashi, Kenji Warigaya, Fumiyoshi Kojima, Kazuo Ono, Shin-Ichi Murata
AIMS: α-Fetoprotein (AFP)-producing gastric carcinoma (AFPGC) is one of the most aggressive GC subtypes. Frequent expression of human epidermal growth factor receptor 2 (HER2) has previously been reported in hepatoid adenocarcinoma (HAC), a major histological subtype of AFPGC originating from common-type GC (CGC). However, HER2 expression levels in other AFPGC histological subtypes are unknown. In this study, we analysed HER2 expression in GCs with primitive phenotypes in addition to HAC...
January 5, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29282006/health-care-costs-associated-with-hospital-acquired-complications-in-patients-with-chronic-kidney-disease
#2
Babak Bohlouli, Terri Jackson, Marcello Tonelli, Brenda Hemmelgarn, Scott Klarenbach
BACKGROUND: Patients with CKD are at increased risk of potentially preventable hospital acquired complications (HACs). Understanding the economic consequences of preventable HACs, may define the scope and investment of initiatives aimed at prevention. METHODS: Adult patients hospitalized from April, 2003 to March, 2008 in Alberta, Canada comprised the study cohort. Healthcare costs were determined and categorized into 'index hospitalization' including hospital cost and in-hospital physician claims, and 'post discharge' including ambulatory care cost, physician claims, and readmission costs from discharge to 90 days...
December 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29281175/novel-starbon-hacs-supported-n-heterocyclic-carbene-iron-iii-catalyst-for-efficient-conversion-of-fructose-to-hmf
#3
Avtar Singh Matharu, Suleiman Ahmed, Badriya Al-Monthery, Duncan Macquarrie, Yoon-Sik Lee, Yohan Kim
: Iron-nitrogen heterocyclic carbenes (Fe-NHCs) have come to the fore because of their ability to be employed in diverse catalytic applications ranging from C-C cross-coupling and C-X bond formation to substitution, reduction, polymerization, and dehydration. The detailed synthesis, characterisation and application of novel heterogeneous Fe-NHC catalysts immobilised on mesoporous expanded starch and Starbon™ 350 for facile fructose to HMF conversion is reported. Both catalyst types showed good performance for the dehydration of fructose to HMF when the reaction was explored at 100 ◦C and varying time (10 min, 20 min, 0...
December 27, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29242210/reversible-immortalisation-enables-genetic-correction-of-human-muscle-progenitors-and-engineering-of-next-generation-human-artificial-chromosomes-for-duchenne-muscular-dystrophy
#4
Sara Benedetti, Narumi Uno, Hidetoshi Hoshiya, Martina Ragazzi, Giulia Ferrari, Yasuhiro Kazuki, Louise Anne Moyle, Rossana Tonlorenzi, Angelo Lombardo, Soraya Chaouch, Vincent Mouly, Marc Moore, Linda Popplewell, Kanako Kazuki, Motonobu Katoh, Luigi Naldini, George Dickson, Graziella Messina, Mitsuo Oshimura, Giulio Cossu, Francesco Saverio Tedesco
Transferring large or multiple genes into primary human stem/progenitor cells is challenged by restrictions in vector capacity, and this hurdle limits the success of gene therapy. A paradigm is Duchenne muscular dystrophy (DMD), an incurable disorder caused by mutations in the largest human gene: dystrophin. The combination of large-capacity vectors, such as human artificial chromosomes (HACs), with stem/progenitor cells may overcome this limitation. We previously reported amelioration of the dystrophic phenotype in mice transplanted with murine muscle progenitors containing a HAC with the entire dystrophin locus (DYS-HAC)...
December 14, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29211452/promoted-chondrogenesis-of-co-cultured-chondrocytes-and-mesenchymal-stem-cells-under-hypoxia-using-in-situ-forming-degradable-hydrogel-scaffolds
#5
Xiaobin Huang, Yong Hou, Leilei Zhong, Dechun Huang, Hongliang Qian, Marcel Karperien, Wei Chen
We investigated the effects of different oxygen tension (21% and 2.5% O2) on the chondrogenesis of different cell systems cultured in pH-degradable PVA hydrogels including human articular chondrocytes (hACs), human mesenchymal stem cells (hMSCs) and their co-cultures with a hAC/hMSC ratio of 20/80. These hydrogels were prepared with vinyl ether acrylate-functionalized PVA (PVA-VEA) and thiolated PVA-VEA (PVA-VEA-SH) via Michael-type addition reaction. The rheology tests determined the gelation of the hydrogels was controlled within 2-7 min dependent on the polymer concentrations...
December 6, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29198062/an-evaluation-of-four-modes-of-low-dose-anticoagulation-during-intermittent-haemodialysis
#6
Malin S E Skagerlind, Bernd G Stegmayr
INTRODUCTION: Intensive care participants that need dialysis frequently suffer from increased risk of bleeding. Standard intermittent haemodialysis (SHD) includes anticoagulation to avoid clotting of the dialysis system. The aim of this study was to clarify which of four different low-dose anticoagulant modes was preferable in reducing the exposure to i.v. unfractionated heparin (heparin) and maintaining patency of the dialysis circuit. METHODS: Twenty-three patients on SHD were included to perform haemodialysis with four modes of low-dose anticoagulation...
December 2, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29178013/research-on-the-ability-of-propionic-acid-and-vitamin-b12-biosynthesis-by-propionibacterium-freudenreichii-strain-t82
#7
Kamil Piwowarek, Edyta Lipińska, Elżbieta Hać-Szymańczuk, Anna Bzducha-Wróbel, Alicja Synowiec
The purpose of this study was to determine the potential for biosynthesis of propionic acid and vitamin B12 by Propionibacterium freudenreichii T82 in a medium containing various sources of carbon (glucose, fructose, and saccharose). These sugars are present in apple pomaces, which are the waste from the production of apple juice. Using statistical analysis design of experiments (DoE), the results allowed us to determine which sugars (carbon sources) exert the most beneficial influence on the biosynthesis of propionic acid and cobalamin...
November 25, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29167919/propionibacterium-spp-source-of-propionic-acid-vitamin-b12-and-other-metabolites-important-for-the-industry
#8
REVIEW
Kamil Piwowarek, Edyta Lipińska, Elżbieta Hać-Szymańczuk, Marek Kieliszek, Iwona Ścibisz
Bacteria from the Propionibacterium genus consists of two principal groups: cutaneous and classical. Cutaneous Propionibacterium are considered primary pathogens to humans, whereas classical Propionibacterium are widely used in the food and pharmaceutical industries. Bacteria from the Propionibacterium genus are capable of synthesizing numerous valuable compounds with a wide industrial usage. Biomass of the bacteria from the Propionibacterium genus constitutes sources of vitamins from the B group, including B12, trehalose, and numerous bacteriocins...
November 22, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29146354/a-novel-calcium-binding-peptide-from-antarctic-krill-protein-hydrolysates-and-identification-of-binding-sites-of-calcium-peptide-complex
#9
Hu Hou, Shikai Wang, Xiao Zhu, Qiqi Li, Yan Fan, Dong Cheng, Bafang Li
Trypsin was used for preparing peptides with high calcium-binding capacity from Antarctic krill. Hydroxyapatite chromatography (HAC), size-exclusion chromatography (SEC), and reversed phase high performance liquid chromatography (RP-HPLC) were used to capture and purify calcium-binding peptides. The peptide sequence was determined to be VLGYIQIR (N- to C-terminal, MW = 960.58 Da), using LTQ Orbitrap XL. According to the results of FTIR and mass spectrometry, chelating site of calcium ions may possibly involve the carbonal or amino groups of Gln, Ile and Arg residues...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29079727/comparison-of-dgt-with-traditional-methods-for-assessing-cadmium-bioavailability-to-brassica-chinensis-in-different-soils
#10
Yunchao Dai, Mubasher Nasir, Yulin Zhang, Haiming Wu, Honghong Guo, Jialong Lv
There is no universally accepted method for evaluating cadmium (Cd) bioavailability in soil. The diffusive gradient in thin films (DGT) technique is a promising tool, but there is considerable debate about its suitability. The ability of this technique to estimate Cd bioavailability in soils was compared with the abilities of other traditional chemical extraction techniques (soil solution, ethylene diamine tetraacetic acid (EDTA), acetic acid (HAc), calcium chloride (CaCl2), and pseudo-total Cd methods) based on a greenhouse experiment using pakchoi (Brassica chinensis) grown in 15 soils from different provinces of China...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29072567/never-events-and-hospital-acquired-conditions-after-kidney-transplant
#11
Linda J Chen, Zhobin Moghadamyeghaneh, Mahmoud Alameddine, Anupam K Gupta, George W Burke, Gaetano Ciancio
INTRODUCTION: Never events (NE) and hospital-acquired conditions (HAC) after surgery have been designated as quality metrics in healthcare by the centres for Medicare and Medicaid Services (CMS). METHODS: The Nationwide Inpatient Sample (NIS) database 2002-2012 was used to identify patients underwent kidney transplant. Multivariate analysis using logistic regression was used to identify outcomes and risk factors of HAC and NE after transplantation; however, we were limited by using a retrospective database missing some important variables specified for the kidney transplant, such as some operative factors, donor factors, and cold and warm ischemia times...
November 11, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29065831/retention-mechanism-of-proteins-in-hydroxyapatite-chromatography-multimodal-interaction-based-protein-separations-a-model-study
#12
Daisuke Itoh, Noriko Yoshimoto, Shuichi Yamamoto
Retention mechanism of proteins in hydroxyapatite chromatography (HAC) was investigated by linear gradient elution experiments. Several mobile phase (buffer) solution strategies and solutes were evaluated in order to probe the relative contributions of two adsorption sites of hydroxyapatite (HA) particles, C-site due to Ca (metal affinity) and P-site due to PO4 (cation-exchange). When P-site was blocked, two basic proteins, lysozyme (Lys) and ribonuclease A(RNase), were not retained whereas cytochrome C(Cyt C) and lactoferrin (LF) were retained and also retention of acidic proteins became stronger as the repulsion due to P-site was eliminated...
October 24, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29064320/the-hospital-acquired-conditions-hac-reduction-program-using-cranberry-treatment-to-reduce-catheter-associated-urinary-tract-infections-and-avoid-medicare-payment-reduction-penalties
#13
T L Saitone, R J Sexton, A Sexton Ward
OBJECTIVE: The Affordable Care Act (ACA) established the Hospital-Acquired Condition (HAC) Reduction Program. The Centers for Medicare and Medicaid Services (CMS) established a total HAC scoring methodology to rank hospitals based upon their HAC performance. Hospitals that rank in the lowest quartile based on their HAC score are subject to a 1% reduction in their total Medicare reimbursements. In FY 2017, 769 hospitals incurred payment reductions totaling $430 million. This study analyzes how improvements in the rate of catheter-associated urinary tract infections (CAUTI), based on the implementation of a cranberry-treatment regimen, impact hospitals' HAC scores and likelihood of avoiding the Medicare-reimbursement penalty...
November 14, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29039973/amendment-of-vanadium-contaminated-soil-with-soil-conditioners-a-study-based-on-pot-experiments-with-canola-plants-brassica-campestris-l
#14
Wenjie Zhang, Jianguo Jiang, Kaimin Li, Tianran Li, De' An Li, Jiaming Wang
We performed pot experiments with canola plants (Brassica campestris L.) to evaluate the effect of eight soil conditioners on the amendment of vanadium (V)-contaminated soil based on analysis of the growth of canola plants and the uptake, bioaccumulation, and translocation of heavy metals. Tested soil conditioners included polyacrylamide (PAM), sepiolite, humic acid (HAC), peat, sludge compost (SC), bentonite, lime, and fly ash. Results from the analysis of the growth of canola plants and the analysis of variance showed that the best soil conditioners for V-contaminated soil were 0...
October 17, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29038254/characterization-of-copy-number-control-of-two-haloferax-volcanii-replication-origins-using-deletion-mutants-and-haloarchaeal-artificial-chromosomes-hacs
#15
Sandy Maurer, Katharina Ludt, Jörg Soppa
Haloferax volcanii is polyploid and contains about 20 genome copies under optimal conditions. However, the chromosome copy number is highly regulated and ranges from two during phosphate starvation to more than 40 under phosphate surplus. The aim of this study was the characterization of the influence of two replication origins on the genome copy number. The origin repeats and the genes encoding Origin Recognition Complex (ORC) proteins were deleted. The core origin oriC1-orc1 (ori1) deletion mutant had a lower genome copy number and a higher fitness than the wild-type, in stark contrast to the oriC2-orc5 (ori2) deletion mutant...
October 16, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29036917/the-effect-of-tio%C3%A2-doped-photocatalytic-nano-additives-on-the-hydration-and-microstructure-of-portland-and-high-alumina-cements
#16
María Pérez-Nicolás, Íñigo Navarro-Blasco, José M Fernández, José Ignacio Alvarez
Mortars with two different binders (Portland cement (PC) and high alumina cement (HAC)) were modified upon the bulk incorporation of nano-structured photocatalytic additives (bare TiO₂, and TiO₂ doped with either iron (Fe-TiO₂) or vanadium (V-TiO₂)). Plastic and hardened state properties of these mortars were assessed in order to study the influence of these nano-additives. Water demand was increased, slightly by bare TiO₂ and Fe-TiO₂, and strongly by V-TiO₂, in agreement with the reduction of the particle size and the tendency to agglomerate...
October 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29027893/hospital-acquired-conditions-predictors-and-implications-for-outcomes-following-spine-tumor-resection
#17
Nikita Lakomkin, Constantinos G Hadjipanayis
OBJECTIVE Hospital-acquired conditions (HACs) significantly compromise patient safety, and have been identified by the Centers for Medicare and Medicaid Services as events that will be associated with penalties for surgeons. The mitigation of HACs must be an important consideration during the postoperative management of patients undergoing spine tumor resection. The purpose of this study was to identify the risk factors for HACs and to characterize the relationship between HACs and other postoperative adverse events following spine tumor resection...
October 13, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29017802/big-data-and-total-hip-arthroplasty-how-do-large-databases-compare
#18
Nicholas A Bedard, Andrew J Pugely, Michael A McHugh, Nathan R Lux, Kevin J Bozic, John J Callaghan
BACKGROUND: Use of large databases for orthopedic research has become extremely popular in recent years. Each database varies in the methods used to capture data and the population it represents. The purpose of this study was to evaluate how these databases differed in reported demographics, comorbidities, and postoperative complications for primary total hip arthroplasty (THA) patients. METHODS: Primary THA patients were identified within National Surgical Quality Improvement Programs (NSQIP), Nationwide Inpatient Sample (NIS), Medicare Standard Analytic Files (MED), and Humana administrative claims database (HAC)...
September 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29016692/benefit-of-early-discharge-among-patients-with-low-risk-pulmonary-embolism
#19
Li Wang, Onur Baser, Phil Wells, W Frank Peacock, Craig I Coleman, Gregory J Fermann, Jeff Schein, Concetta Crivera
Clinical guidelines recommend early discharge of patients with low-risk pulmonary embolism (LRPE). This study measured the overall impact of early discharge of LRPE patients on clinical outcomes and costs in the Veterans Health Administration population. Adult patients with ≥1 inpatient diagnosis for pulmonary embolism (PE) (index date) between 10/2011-06/2015, continuous enrollment for ≥12 months pre- and 3 months post-index date were included. PE risk stratification was performed using the simplified Pulmonary Embolism Stratification Index...
2017: PloS One
https://www.readbyqxmd.com/read/28985613/preventable-complications-in-epilepsy-admissions-the-july-effect
#20
Natalie S Pierson, Daniel R Kramer, Timothy Wen, Lianne Ho, Arati Patel, Daniel Donoho, Vivek Mehta, Christianne Heck, Brian Lee, William J Mack, Charles Y Liu
BACKGROUND: Inpatient hospital stays for patients with epilepsy represent a significant burden on patients and society. Identifying factors that contribute to such costs aides in developing effective strategies to address this burden. July admissions have been associated with higher rates of complications and worse outcomes, attributed to the presence of new physicians. This study aims to evaluate whether epilepsy patients admitted in July have higher preventable complication rates and mortality than during the rest of the year...
November 2017: Epilepsy Research
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