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https://www.readbyqxmd.com/read/28594185/double-magnetic-relaxation-and-magnetocaloric-effect-in-the-mn9-w-cn-8-6-4-4-dpds-4-cluster-based-network
#1
Piotr Konieczny, Szymon Chorazy, Robert Pełka, Klaudia Bednarek, Tadeusz Wasiutyński, Stanisław Baran, Barbara Sieklucka, Robert Podgajny
Cyanide-bridged {Mn(II)9[W(V)(CN)8]6} clusters with the ground state spin SSG = 39/2 were connected by a 4,4'-dipyridyl disulfide (4,4'-dpds) linker into 2-D double-connected coordination layers of the I(0)O(2) type, {Mn(II)9(4,4'-dpds)4(MeOH)16[W(V)(CN)8]6}·12MeOH (1). The intercluster contacts are controlled by the bridging Mn(II)-(4,4'-dpds)-Mn(II) coordination modes and direct hydrogen bonds W-CN···HOMeOH-Mn in three crystallographic directions, with the vertex-to-vertex contact unprecedented in {Mn9W6}-based networks dominating over the typical edge-to-edge contacts...
June 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28581730/tellurotungstate-based-organotin-rare-earth-heterometallic-hybrids-with-four-organic-components
#2
Qing Han, Jian-Cai Liu, Yue Wen, Li-Juan Chen, Jun-Wei Zhao, Guo-Yu Yang
A family of unprecedented tellurotungstate-based organotin-rare-earth (RE) heterometallic hybrids [H2N(CH3)2]6H12Na2 {[Sn(CH3)W2O4(IN)][(B-α-TeW8O31)RE(H2O) (Ac)]2}2·25H2O [RE = Ce(III) (1), Pr(III) (2), Nd(III) (3), Sm(III) (4), Eu(III) (5), Gd(III) (6), Tb(III) (7); HIN = isonicotinic acid, HAc = acetic acid] were synthesized and characterized by elemental analyses, IR spectra, UV spectra, thermogravimetric analyses, powder X-ray diffraction, and single-crystal X-ray diffraction. The polyoxoanionic skeletons {[Sn(CH3)W2O4(IN)][(B-α-TeW8O31)RE(H2O) (Ac)]2}2(20-) of 1-7 are constructed from two symmetrical units {[Sn(CH3)W2O4(IN)][(B-α-TeW8O31)RE(H2O) (Ac)]2}(10-) linked by two acetate connectors, which not only represent the first inorganic-organic hybrid RE-substituted tellurotungstates involving three different organic ligands, but also stand for the first samples of organotin-RE heterometallic polyoxometalate derivatives...
June 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28575991/electrospun-pcl-gelatin-composite-nanofiber-structures-for-effective-guided-bone-regeneration-membranes
#3
Ke Ren, Yi Wang, Tao Sun, Wen Yue, Hongyu Zhang
Guided bone regeneration (GBR) membranes have been proved of great benefit for bone tissue engineering due to the improvement of cell attachment and proliferation. To develop GBR membranes with better biocompatibility and more proper degradation ability, here we fabricated polycaprolactone (PCL, polymer)/gelatin (protein) hybrid nanofibrous GBR membranes via electrospinning, followed by crosslinking with genipin. Acetic acid (HAc) was utilized to resolve the phase separation of PCL and gelatin, therefore homogeneous PCL/gelatin hybrid nanofibers with different ratios were successfully prepared...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28569157/effects-of-sesamin-on-chondroitin-sulfate-proteoglycan-synthesis-induced-by-interleukin-1beta-in-human-chondrocytes
#4
Warunee Srisuthtayanont, Dumnoensun Pruksakorn, Prachya Kongtawelert, Peraphan Pothacharoen
BACKGROUND: Numerous studies have reported on the health benefits of sesamin, a major lignin found in sesame (S. indicum) seeds. Recently, sesamin was shown to have the ability to promote chondroitin sulfate proteoglycan synthesis in normal human chondrocytes. This study assesses the anti-inflammatory effect of sesamin on proteoglycans production in 3D chondrocyte cultures. METHODS: To evaluate the effects of sesamin on IL-1β-treated human articular chondrocytes (HAC) pellets, the pellets were pre-treated with IL-1β then cultured in the presence of various concentrations of sesamin for 21 days...
May 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28557714/innovative-use-of-the-electronic-health-record-to-support-harm-reduction-efforts
#5
Daniel Hyman, Jenae Neiman, Michael Rannie, Renee Allen, Marguerite Swietlik, Andrea Balzer
BACKGROUND AND OBJECTIVES: Awareness of the impact of preventable harm on patients and families has resulted in extensive efforts to make our health care systems safer. We determined that, in our hospital, patients experienced 1 of 9 types of preventable harm approximately every other day. In an effort to expedite early identification of patients at risk and provide timely intervention, we used the electronic health record's (EHR) documentation to enable decision support, data capture, and auditing and implemented reporting tools to reduce rates of harm...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28554616/essential-oils-as-food-eco-preservatives-model-system-studies-on-the-effect-of-temperature-on-limonene-antibacterial-activity
#6
Katarzyna Hąc-Wydro, Michał Flasiński, Karolina Romańczuk
Antimicrobial properties of essential oils predestine these substances to be used as ecological food preservatives. However, their activity is determined by variety of factors among which external conditions and food properties are highly important. Herein the influence of limonene on artificial membranes was studied to verify the effect of temperature on the incorporation of this compound into model bacterial membrane. The investigations were done on lipid monolayers and the experiments involved the surface pressure-area measurements, penetration studies and Brewster Angle Microscopy analysis...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28554111/retrieval-of-au-ag-cu-precious-metals-coupled-with-electric-energy-production-via-an-unconventional-coupled-redox-fuel-cell-reactor
#7
Hui-Min Zhang, Zheng Fan, Wei Xu, Xiao Feng, Zu-Cheng Wu
The recovery of heavy metals from aqueous solutions or e-wastes is of upmost importance. Retrieval of Au, Ag, and Cu with electricity generation through building an ethanol-metal coupled redox fuel cells (CRFCs) is demonstrated. The cell was uniquely assembled on PdNi/C anode the electro-oxidation of ethanol takes place to give electrons and then go through the external circuit reducing metal ions to metallic on the cathode, metals are recovered. Taking an example of removal of 100mgL(-1) gold in 0.5M HAc-NaAc buffer solution as the catholyte, 2...
May 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28551363/salamanders-on-the-bench-a-biocompatibility-study-of-salamander-skin-secretions-in-cell-cultures
#8
Janek von Byern, Dietrich Mebs, Egon Heiss, Ursula Dicke, Oliver Wetjen, Kristin Bakkegard, Ingo Grunwald, Susanne Wolbank, Severin Mühleder, Alfred Gugerell, Heidemarie Fuchs, Sylvia Nuernberger
Salamanders have evolved a wide variety of antipredator mechanisms and behavior patterns, including toxins and noxious or adhesive skin secretions. The high bonding strength of the natural bioadhesives makes these substances interesting for biomimetic research and applications in industrial and medical sectors. Secretions of toxic species may help to understand the direct effect of harmful substances on the cellular level. In the present study, the biocompatibility of adhesive secretions from four salamander species (Plethodon shermani, Plethodon glutinosus, Ambystoma maculatum, Ambystoma opacum) were analyzed using the MTT assay in cell culture and evaluated against toxic secretions of Pleurodeles waltl, Triturus carnifex, Pseudotriton ruber, Tylototriton verrucosus, and Salamandra salamandra...
May 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28550061/the-lectin-chaperone-calnexin-is-involved-in-endoplasmic-reticulum-stress-response-by-regulating-ca-2-homeostasis-in-aspergillus-nidulans
#9
Shenghua Zhang, Hailin Zheng, Qiuyi Chen, Yuan Chen, Sha Wang, Ling Lu, Shizhu Zhang
The Ca(2+)-mediated signaling pathway is crucial for environmental adaptation in fungi. Here we show that calnexin, a molecular chaperone located in the endoplasmic reticulum (ER), plays an important role in regulating cytosolic free calcium concentration ([Ca(2+)]c) in Aspergillus nidulans Inactivation of calnexin (ClxA) in A. nidulans caused severe defects in hyphal growth and conidiation under ER stress caused by the ER-stress inducing agent dithiothreitol (DTT) or high temperature. Importantly, defects in the ΔclxA mutant were restored by the addition of extracellular calcium...
May 26, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28538704/climate-change-and-its-impact-on-the-yield-of-major-food-crops-evidence-from-pakistan
#10
Sajjad Ali, Ying Liu, Muhammad Ishaq, Tariq Shah, Abdullah, Aasir Ilyas, Izhar Ud Din
Pakistan is vulnerable to climate change, and extreme climatic conditions are threatening food security. This study examines the effects of climate change (e.g., maximum temperature, minimum temperature, rainfall, relative humidity, and the sunshine) on the major crops of Pakistan (e.g., wheat, rice, maize, and sugarcane). The methods of feasible generalized least square (FGLS) and heteroscedasticity and autocorrelation (HAC) consistent standard error were employed using time series data for the period 1989 to 2015...
May 24, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28534415/sequence-and-structure-dual-dependent-interaction-between-small-molecules-and-dna-for-the-detection-of-residual-silver-ions-in-as-prepared-silver-nanomaterials
#11
Zhaoyin Wang, Jian Zhao, Zijun Li, Jianchun Bao, Zhihui Dai
Investigations on interaction between small molecules and DNA are the basis of designing advanced bioanalytical systems. We herein propose a novel interaction between heterocyclic aromatic compounds (HACs) and single-stranded DNA (ssDNA). Taking methylene blue (MB) as a typical HAC, it is found that MB can interact with cytosine (C)-rich ssDNA in an enthalpy-driven process. The interaction between MB and C-rich ssDNA is sequence and structure dual-dependent: at least three consecutive C and single-stranded structure are necessary, affecting the fluorescence response of metal nanoparticles...
June 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28529745/hepatoid-adenocarcinoma-of-the-lung-metastasizing-to-the-tonsil
#12
Luca Valle, Joel Thomas, Chul Kim, Eva Szabo, G Thomas Brown, Deborah Citrin, Arun Rajan
Hepatoid adenocarcinoma (HAC) is a rare tumor that typically originates in gastrointestinal tissue, such as the stomach, but can also occasionally originate in the lung. The majority of HACs express α-fetoprotein (AFP) on tumor cells, and serum AFP can be used as a marker of response to treatment or disease progression. HAC has a poor prognosis, although early diagnosis and aggressive treatment can result in long-term survival. To the best of our knowledge, this is the first reported case of HAC metastasizing to the tonsil...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28515021/sulforaphene-an-isothiocyanate-present-in-radish-plants-inhibits-proliferation-of-human-breast-cancer-cells
#13
Anna Pawlik, Marta Wała, Aleksandra Hać, Agnieszka Felczykowska, Anna Herman-Antosiewicz
BACKGROUND: Isothiocyanates derived from the Brassicaceae plants possess chemopreventive and anticancer activities. One of them is sulforaphene (SF), which is abundant in Rhapanus sativus seeds. The underlying mechanism of its anticancer activity is still underexplored. PURPOSE: SF properties make it an interesting candidate for cancer prevention and therapy. Thus, it is crucial to characterize the mechanism of its activity. STUDY DESIGN: We investigated the mechanism of antiproliferative activity of SF in breast cancer cells differing in growth factor receptors status and lacking functional p53...
June 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28489365/between-descriptors-and-properties-understanding-the-ligand-efficiency-trends-for-g-protein-coupled-receptor-and-kinase-structure-activity-data-sets
#14
Jaroslaw Polanski, Aleksandra Tkocz
The chemical meaning of the ligand efficiency (LE) metrics is explained in this paper using a large G protein-coupled receptor (GPCR) and kinase structure-activity (IC50, Ki) data set. Although there is a controversy in the literature regarding both the mathematical validity and the performance of LE, it is in common use as an early estimator for drug optimization. Apparently, the numerous con arguments are not convincing enough. We show here for the first time that the main misunderstanding of the chemical meaning of LE is its interpretation as a molecular descriptor connected with a single molecule...
May 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28456126/assessing-the-influence-of-the-carbon-source-on-the-abatement-of-industrial-n2o-emissions-coupled-with-the-synthesis-of-added-value-bioproducts
#15
Osvaldo D Frutos, Gonzalo Barriguín, Raquel Lebrero, Raúl Muñoz
The continuous abatement of a synthetic N2O emission from a nitric acid plant coupled with the simultaneously production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) copolymer and the coenzyme Q10 (CoQ10) in a bubble column reactor (BCR) was tested using methanol, glycerol and a mixture of sodium acetate-acetic acid (Ac-HAc) as a carbon and electron donor source. The BCRs were inoculated with Paracoccus denitrificans and supplied with the carbon/electron donor at a loading rate of 139gCm(-3)d(-1)...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28455603/an-active-drimane-type-lactone-from-polygonum-jucundum-attenuates-lipopolysaccharide-induced-acute-lung-injury-in-mice-through-tlr4-mapks-signaling-pathway
#16
Yang Hu, Lijun Tao, Hui Tan, Mian Zhang, Kuniyoshi Shimizu, Fei Zhang, Chaofeng Zhang
The herbs of Polygonum jucundum Lindex. (Polygonaceae) is a traditional Chinese medicine for inflammatory diseases. 2α-Hydroxyl-3β-angeloylcinnamolide (HAC), a drimane-type sesquiterpenoid, was the major active compound of the ethanol extract of P. jucundum which inhibited the production of inflammatory mediators. However, the biological mechanism of HAC for anti-inflammatory activity has not been reported. In the current study, we investigated whether HAC could suppress the production of inflammatory mediators in lipopolysaccharide (LPS)-induced acute lung injury in mice (ALI) through downregulation of Toll-like receptor 4 (TLR4) and activations of mitogen-activated protein kinases (MAPKs) and inducible protein nitric oxide synthase (iNOS)...
April 28, 2017: Inflammation
https://www.readbyqxmd.com/read/28450414/adverse-outcomes-associated-with-preventable-complications-in-hospitalized-patients-with-ckd
#17
Babak Bohlouli, Terri Jurgens Jackson, Marcello Tonelli, Brenda Hemmelgarn, Scott Klarenbach
BACKGROUND: and objectives Patients with CKD are at risk of hospital-acquired complications (HACs). We sought to determine the association of preventable HACs with mortality, length of stay (LOS), and readmission. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All adults hospitalized from April of 2003 to March of 2008 in Alberta were characterized by kidney function and occurrence of preventable HACs. CKD was defined by eGFR<60 ml/min per 1.73 m(2) and/or albumin-to-creatinine ratio >3-30 mg/mmol for >3 months in the time frame from 365 to 90 days before admission...
May 8, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28439356/impact-of-the-2003-acgme-resident-duty-hour-reform-on-hospital-acquired-conditions-a-national-retrospective-analysis
#18
Timothy Wen, Frank J Attenello, Steven Y Cen, Alexander A Khalessi, May Kim-Tenser, Nerses Sanossian, Steven L Giannotta, Arun P Amar, William J Mack
BACKGROUND: The Accreditation Council for Graduate Medical Education reforms in 2003 instituted an 80-hour weekly limit for resident physicians. Critics argue that these restrictions have increased handoffs among residents and the potential for a decline in patient safety. "Never events" hospital-acquired conditions (HACs) are a set of preventable events used as a quality metric in hospital safety analyses. OBJECTIVE: This analysis evaluated post-work hour reform effects on HAC incidence for US hospital inpatients, using the National Inpatient Sample...
April 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28421242/ct-features-of-hepatic-metastases-from-hepatoid-adenocarcinoma
#19
Min-Yung Chang, Hye Jin Kim, Seung Hyun Park, Hyunki Kim, Dong Kyu Choi, Joon Seok Lim, Mi-Suk Park, Myeong-Jin Kim, Honsoul Kim
PURPOSE: The purpose of this study was to report the imaging presentation of hepatic metastases from hepatoid adenocarcinoma (HAC). METHODS: We retrospectively identified 11 patients (10 men and 1 woman; median age 66) with HAC liver metastasis who underwent contrast-enhanced computed tomography (CT) which included arterial phase and portal venous phase. Two radiologists analyzed the imaging parameters, which included the enhancement pattern on arterial and portal phase images, necrosis, venous thrombi, and overall imaging diagnosis, and arrived at a consensus...
April 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28420736/deciphering-the-regulatory-network-between-the-srebp-pathway-and-protein-secretion-in-neurospora-crassa
#20
Lina Qin, Vincent W Wu, N Louise Glass
Sterol regulatory element binding proteins (SREBPs) are conserved from yeast to mammalian cells and function in the regulation of sterol homeostasis. In fungi, the SREBP pathway has been implicated in the adaptation to hypoxia and in virulence. In Neurospora crassa and Trichoderma reesei, the SREBP pathway also negatively regulates protein secretion under lignocellulolytic conditions. Here we utilized global transcriptional profiling combined with genetic and physiological analyses to address the regulatory link between the SREBP pathway and protein secretion in N...
April 18, 2017: MBio
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