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https://www.readbyqxmd.com/read/28538704/climate-change-and-its-impact-on-the-yield-of-major-food-crops-evidence-from-pakistan
#1
Sajjad Ali, Ying Liu, Muhammad Ishaq, Tariq Shah, Abdullah, Aasir Ilyas, Izhar Ud Din
Pakistan is vulnerable to climate change, and extreme climatic conditions are threatening food security. This study examines the effects of climate change (e.g., maximum temperature, minimum temperature, rainfall, relative humidity, and the sunshine) on the major crops of Pakistan (e.g., wheat, rice, maize, and sugarcane). The methods of feasible generalized least square (FGLS) and heteroscedasticity and autocorrelation (HAC) consistent standard error were employed using time series data for the period 1989 to 2015...
May 24, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28534415/sequence-and-structure-dual-dependent-interaction-between-small-molecules-and-dna-for-the-detection-of-residual-silver-ions-in-as-prepared-silver-nanomaterials
#2
Zhaoyin Wang, Jian Zhao, Zijun Li, Jianchun Bao, Zhihui Dai
Investigations on interaction between small molecules and DNA are the basis of designing advanced bioanalytical systems. We herein propose a novel interaction between heterocyclic aromatic compounds (HACs) and single-stranded DNA (ssDNA). Taking methylene blue (MB) as a typical HAC, it is found that MB can interact with cytosine (C)-rich ssDNA in an enthalpy-driven process. The interaction between MB and C-rich ssDNA is sequence and structure dual-dependent: at least three consecutive C and single-stranded structure are necessary...
May 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28529745/hepatoid-adenocarcinoma-of-the-lung-metastasizing-to-the-tonsil
#3
Luca Valle, Joel Thomas, Chul Kim, Eva Szabo, G Thomas Brown, Deborah Citrin, Arun Rajan
Hepatoid adenocarcinoma (HAC) is a rare tumor that typically originates in gastrointestinal tissue, such as the stomach, but can also occasionally originate in the lung. The majority of HACs express α-fetoprotein (AFP) on tumor cells, and serum AFP can be used as a marker of response to treatment or disease progression. HAC has a poor prognosis, although early diagnosis and aggressive treatment can result in long-term survival. To the best of our knowledge, this is the first reported case of HAC metastasizing to the tonsil...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28515021/sulforaphene-an-isothiocyanate-present-in-radish-plants-inhibits-proliferation-of-human-breast-cancer-cells
#4
Anna Pawlik, Marta Wała, Aleksandra Hać, Agnieszka Felczykowska, Anna Herman-Antosiewicz
BACKGROUND: Isothiocyanates derived from the Brassicaceae plants possess chemopreventive and anticancer activities. One of them is sulforaphene (SF), which is abundant in Rhapanus sativus seeds. The underlying mechanism of its anticancer activity is still underexplored. PURPOSE: SF properties make it an interesting candidate for cancer prevention and therapy. Thus, it is crucial to characterize the mechanism of its activity. STUDY DESIGN: We investigated the mechanism of antiproliferative activity of SF in breast cancer cells differing in growth factor receptors status and lacking functional p53...
June 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28489365/between-descriptors-and-properties-understanding-the-ligand-efficiency-trends-for-g-protein-coupled-receptor-and-kinase-structure-activity-data-sets
#5
Jaroslaw Polanski, Aleksandra Tkocz
The chemical meaning of the ligand efficiency (LE) metrics is explained in this paper using a large G protein-coupled receptor (GPCR) and kinase structure-activity (IC50, Ki) data set. Although there is a controversy in the literature regarding both the mathematical validity and the performance of LE, it is in common use as an early estimator for drug optimization. Apparently, the numerous con arguments are not convincing enough. We show here for the first time that the main misunderstanding of the chemical meaning of LE is its interpretation as a molecular descriptor connected with a single molecule...
May 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28456126/assessing-the-influence-of-the-carbon-source-on-the-abatement-of-industrial-n2o-emissions-coupled-with-the-synthesis-of-added-value-bioproducts
#6
Osvaldo D Frutos, Gonzalo Barriguín, Raquel Lebrero, Raúl Muñoz
The continuous abatement of a synthetic N2O emission from a nitric acid plant coupled with the simultaneously production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) copolymer and the coenzyme Q10 (CoQ10) in a bubble column reactor (BCR) was tested using methanol, glycerol and a mixture of sodium acetate-acetic acid (Ac-HAc) as a carbon and electron donor source. The BCRs were inoculated with Paracoccus denitrificans and supplied with the carbon/electron donor at a loading rate of 139gCm(-3)d(-1)...
April 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28455603/an-active-drimane-type-lactone-from-polygonum-jucundum-attenuates-lipopolysaccharide-induced-acute-lung-injury-in-mice-through-tlr4-mapks-signaling-pathway
#7
Yang Hu, Lijun Tao, Hui Tan, Mian Zhang, Kuniyoshi Shimizu, Fei Zhang, Chaofeng Zhang
The herbs of Polygonum jucundum Lindex. (Polygonaceae) is a traditional Chinese medicine for inflammatory diseases. 2α-Hydroxyl-3β-angeloylcinnamolide (HAC), a drimane-type sesquiterpenoid, was the major active compound of the ethanol extract of P. jucundum which inhibited the production of inflammatory mediators. However, the biological mechanism of HAC for anti-inflammatory activity has not been reported. In the current study, we investigated whether HAC could suppress the production of inflammatory mediators in lipopolysaccharide (LPS)-induced acute lung injury in mice (ALI) through downregulation of Toll-like receptor 4 (TLR4) and activations of mitogen-activated protein kinases (MAPKs) and inducible protein nitric oxide synthase (iNOS)...
April 28, 2017: Inflammation
https://www.readbyqxmd.com/read/28450414/adverse-outcomes-associated-with-preventable-complications-in-hospitalized-patients-with-ckd
#8
Babak Bohlouli, Terri Jurgens Jackson, Marcello Tonelli, Brenda Hemmelgarn, Scott Klarenbach
BACKGROUND: and objectives Patients with CKD are at risk of hospital-acquired complications (HACs). We sought to determine the association of preventable HACs with mortality, length of stay (LOS), and readmission. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All adults hospitalized from April of 2003 to March of 2008 in Alberta were characterized by kidney function and occurrence of preventable HACs. CKD was defined by eGFR<60 ml/min per 1.73 m(2) and/or albumin-to-creatinine ratio >3-30 mg/mmol for >3 months in the time frame from 365 to 90 days before admission...
May 8, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28439356/impact-of-the-2003-acgme-resident-duty-hour-reform-on-hospital-acquired-conditions-a-national-retrospective-analysis
#9
Timothy Wen, Frank J Attenello, Steven Y Cen, Alexander A Khalessi, May Kim-Tenser, Nerses Sanossian, Steven L Giannotta, Arun P Amar, William J Mack
BACKGROUND: The Accreditation Council for Graduate Medical Education reforms in 2003 instituted an 80-hour weekly limit for resident physicians. Critics argue that these restrictions have increased handoffs among residents and the potential for a decline in patient safety. "Never events" hospital-acquired conditions (HACs) are a set of preventable events used as a quality metric in hospital safety analyses. OBJECTIVE: This analysis evaluated post-work hour reform effects on HAC incidence for US hospital inpatients, using the National Inpatient Sample...
April 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28421242/ct-features-of-hepatic-metastases-from-hepatoid-adenocarcinoma
#10
Min-Yung Chang, Hye Jin Kim, Seung Hyun Park, Hyunki Kim, Dong Kyu Choi, Joon Seok Lim, Mi-Suk Park, Myeong-Jin Kim, Honsoul Kim
PURPOSE: The purpose of this study was to report the imaging presentation of hepatic metastases from hepatoid adenocarcinoma (HAC). METHODS: We retrospectively identified 11 patients (10 men and 1 woman; median age 66) with HAC liver metastasis who underwent contrast-enhanced computed tomography (CT) which included arterial phase and portal venous phase. Two radiologists analyzed the imaging parameters, which included the enhancement pattern on arterial and portal phase images, necrosis, venous thrombi, and overall imaging diagnosis, and arrived at a consensus...
April 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28420736/deciphering-the-regulatory-network-between-the-srebp-pathway-and-protein-secretion-in-neurospora-crassa
#11
Lina Qin, Vincent W Wu, N Louise Glass
Sterol regulatory element binding proteins (SREBPs) are conserved from yeast to mammalian cells and function in the regulation of sterol homeostasis. In fungi, the SREBP pathway has been implicated in the adaptation to hypoxia and in virulence. In Neurospora crassa and Trichoderma reesei, the SREBP pathway also negatively regulates protein secretion under lignocellulolytic conditions. Here we utilized global transcriptional profiling combined with genetic and physiological analyses to address the regulatory link between the SREBP pathway and protein secretion in N...
April 18, 2017: MBio
https://www.readbyqxmd.com/read/28410465/potentially-preventable-complications-in-epilepsy-admissions-the-weekend-effect
#12
Lianne Ho, Daniel R Kramer, Timothy Wen, Alimohammad S Moalem, David Millett, Christianne N Heck, William J Mack, Charles Y Liu
INTRODUCTION: Epilepsy affects approximately 1% of the population in the United States with frequent hospital admissions accounting for a significant burden on patients and society as a whole. Weekend admissions have generally been found to have poorer outcomes compared to weekday admissions with increased rates of preventable complications, such as nationally identified "hospital-acquired conditions" (HAC). OBJECTIVE: This study aimed to assess the impact of weekend admission on HACs and mortality in the adult epilepsy population...
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28407319/effect-of-intravenous-or-perivascular-injection-of-synthetic-adrenocorticotropic-hormone-on-stimulation-test-results-in-dogs
#13
C M Johnson, P H Kass, T A Cohen, E C Feldman
BACKGROUND: Standard protocols for adrenocorticotropic hormone (ACTH) stimulation testing (ACTHst) often involve intravenous (IV) injection of corticotropin. ACTH might be unintentionally injected into the perivascular (PV) space. OBJECTIVE: To compare stimulation test results after IV and PV injections of ACTH. ANIMALS: Twenty privately owned dogs were studied: 10 healthy and 10 with trilostane-treated naturally occurring hyperadrenocorticism (HAC)...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28406842/hfe-gene-mutations-and-iron-status-in-100-healthy-polish-children
#14
Barbara Kaczorowska-Hac, Marcin Luszczyk, Jedrzej Antosiewicz, Wieslaw Ziolkowski, Elzbieta Adamkiewicz-Drozynska, Malgorzata Mysliwiec, Ewa Milosz, Jan J Kaczor
Iron participates in oxygen transport, energetic, metabolic, and immunologic processes. There are 2 main causes of iron overload: hereditary hemochromatosis which is a primary cause, is a metabolic disorder caused by mutations of genes that control iron metabolism and secondary hemochromatosis caused by multitransfusions, chronic hemolysis, and intake of iron rich food. The most common type of hereditary hemochromatosis is caused by HFE gene mutation. In this study, we analyzed iron metabolism in 100 healthy Polish children in relation to their HFE gene status...
April 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28401424/hospital-acquired-conditions-are-associated-with-worse-outcomes-in-crohn-s-disease-related-hospitalizations
#15
Kenneth Obi, Alice Hinton, Lindsay Sobotka, Edward Levine, Darwin Conwell, Cheng Zhang
BACKGROUND: Crohn's disease (CD) is a chronically relapsing condition that frequently requires hospitalization. In 2008, the Centers for Medicare and Medicaid Services selected ten conditions that were deemed healthcare-acquired conditions (HACs). Costs related to HACs are not reimbursed as they are considered to be preventable. AIM: To determine the prevalence and impact of HACs on hospital outcomes of hospitalized CD patients. METHODS: This was a cross-sectional study using data from the Nationwide Inpatient Sample between 2007 and 2011 with an extended time frame between 2002 and 2013 to specifically evaluate the prevalence of HACs...
April 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28393714/gender-difference-of-hepatic-and-intestinal-cyp3a4-in-cyp3a-humanized-mice-generated-by-a-human-chromosome-engineering-technique
#16
Kaoru Kobayashi, Chihiro Abe, Mika Endo, Yasuhiro Kazuki, Mitsuo Oshimura, Kan Chiba
BACKGROUND: Cytochrome P450 3A4 (CYP3A4) is an important drug-metabolizing enzyme that is expressed in the liver and small intestine of humans. Various factors influence the expression of CYP3A4, but gender difference in CYP3A4 expression remains debatable. OBJECTIVE: To clarify gender difference of hepatic and intestinal CYP3A4 in CYP3A-humanized mice generated by a human artificial chromosome (HAC) vector system. The CYP3A-humanized (CYP3A-HAC) mice have essential regulatory regions, including promoters and enhancers, and unknown elements affecting the expression of CYP3A4...
April 4, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28361288/evolution-of-h5-highly-pathogenic-avian-influenza-sequence-data-indicate-stepwise-changes-in-the-cleavage-site
#17
Celia Abolnik
The genetic composition of an H5 subtype hemagglutinin gene quasispecies, obtained from ostrich tissues that had been infected with H5 subtype influenza virus was analysed using a next generation sequencing approach. The first evidence for the reiterative copying of a poly (U) stretch in the connecting peptide region in the haemagglutinin cleavage site (HACS) by the viral RNA-dependent RNA polymerase (RdRp) is provided. Multiple non-consensus species of RNA were detected in the infected host, corresponding to likely intermediate sequences between the putative low pathogenic precursor nucleotide sequence of the H5 influenza strain and the highly pathogenic avian influenza virus gene sequence...
March 30, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28343956/effect-of-cd-2-and-cd-2-auxin-mixtures-on-lipid-monolayers-model-membrane-studies-on-the-role-of-auxins-in-phytoremediation-of-metal-ions-from-contaminated-environment
#18
Katarzyna Hąc-Wydro, Marzena Mach, Karolina Węder, Katarzyna Pająk, Paweł Wydro
In this work Langmuir monolayer experiments were performed to analyze the effect of Cd(2+) ions and their mixtures with synthetic auxin (1-naphthaleneacetic acid - NAA) on lipid films. These investigations were motivated by the fact that auxins act effectively as the agents improving the removal of metal ions from contaminated water and soil by plants (phytoextraction), and although their mechanism of action in this area is still unclear, it was suggested that it can be membrane-related. The experiments were done for one component (1,2-dipalmitoyl-sn-glycero-3-phosphocholine - DPPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine - DOPC; 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) - DPPG) monolayers and mixed (DPPG/DOPC and DPPG/DPPC) films treated as model of plant leaves membranes...
March 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28341771/small-chromosomal-regions-position-themselves-autonomously-according-to-their-chromatin-class
#19
Harmen Jan George van de Werken, Josien C de Haan, Yana Feodorova, Dominika Bijos, An Weuts, Koen Theunis, Sjoerd Holwerda, Wouter Meuleman, Ludo Pagie, Katharina Thanisch, Parveen Kumar, Heinrich Leonhardt, Peter Marynen, Bas van Steesel, Thierry Voet, Wouter de Laat, Irina Solovei, Boris Joffe
The spatial arrangement of chromatin is linked to the regulation of nuclear processes. One striking aspect of nuclear organization is the spatial segregation of heterochromatic and euchromatic domains. The mechanisms of this chromatin segregation are still poorly understood. In this work we investigated the link between the primary genomic sequence and chromatin domains. We analyzed the spatial intranuclear arrangement of a human artificial chromosome (HAC) in a xenospecific mouse background in comparison to an orthologous region of native mouse chromosome...
March 24, 2017: Genome Research
https://www.readbyqxmd.com/read/28339078/comparative-evaluation-of-the-effects-of-platelet%C3%A2-rich-plasma-formulations-on-extracellular-matrix-formation-and-the-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-human-articular-chondrocytes
#20
Wenjing Yin, Haitao Xu, Jiagen Sheng, Zhengliang Xu, Xuetao Xie, Changqing Zhang
Concentrated leukocytes in leukocyte and platelet‑rich plasma (L‑PRP) may deliver increased levels of pro‑inflammatory cytokines to activate the nuclear factor (NF)‑κB signaling pathway, to counter or overwhelm the beneficial effects of growth factors on cartilage regeneration. However, to date, no relevant studies have substantiated this. In the present study, L‑PRP and pure platelet‑rich plasma (P‑PRP) were prepared, and leukocytes, platelets, pro‑inflammatory cytokines and growth factor concentrations were quantified; they were then used to treat human articular chondrocytes (HACs)...
May 2017: Molecular Medicine Reports
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