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Corinna K Sokoll, Susanne Winter
BACKGROUND: After over 27 years of existence, the executive board of the Health Advisory Council of the state capital Munich (HAC) decided to conduct an inventory. PURPOSE OF THE STUDY: The objective was to gather data on the perceptions of HAC participants regarding the structure of committees, issues addressed, their processing as well as the results of the projects, in addition to events organized, public relations activities and target achievement. The survey should be the basis for decisions regarding future directions or further developments of the HAC...
May 16, 2018: Das Gesundheitswesen
Timothy Edwards, Julia Williams, Michaela Cottee
OBJECTIVE: To describe the association between prehospital airway management and neurological outcomes in patients transferred by the ambulance service directly to a heart attack centre (HAC) post-return of spontaneous circulation (ROSC). METHODS: A retrospective observational cohort study in which ambulance records were reviewed to determine prehospital airway management strategy and collect physiological and demographic data. HAC notes were obtained to determine in-hospital management and quantify neurological outcome via the cerebral performance category (CPC) scale...
May 11, 2018: Emergency Medicine Australasia: EMA
Yoichi Akazawa, Tsuyoshi Saito, Takuo Hayashi, Yuka Yanai, Sho Tsuyama, Keisuke Akaike, Yoshiyuki Suehara, Fumiyuki Takahashi, Kazuya Takamochi, Hiroya Ueyama, Takashi Murakami, Sumio Watanabe, Akihito Nagahara, Takashi Yao
Histologically tubulo-papillary structures with glycogen-rich clear cytoplasm in gastric adenocarcinoma with enteroblastic differentiation (GAED) are well-known, but a solid growth pattern can also be observed as a minor component. In contrast, hepatoid adenocarcinoma (HAC) of the stomach shows many overlapping features, including solid pattern and alpha-fetoprotein expression. In this study, we employed next-generation sequencing (NGS) to establish a molecular/clinicopathological concept of GAED and clarify whether these two tumors should be grouped together in one category...
May 8, 2018: Human Pathology
Diego Daniel Miceli, Adriana María Belén Abiuso, Patricia Noemi Vidal, María Florencia Gallelli, Omar Pedro Pignataro, Victor Alejandro Castillo
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) is an enzyme that activates cortisone into cortisol in tissues. Alterations in this enzyme are related to the development of metabolic syndrome, obesity and hyperadrenocorticism (HAC). Endothelial nitric oxide synthase (eNOS) produces nitric oxide and is related to the regulation of adrenal steroidogenesis. The aim of the study was to evaluate 11β-HSD1 and eNOS expression in dogs with HAC. Visceral adipose tissue samples were taken to evaluate 11β-HSD1 expression by immunohistochemistry and western blotting...
2018: Open Veterinary Journal
Rogério Figueiredo, Rafael Pereira, Osmar Pinto Neto
This study aimed to compare the heart autonomic control (HAC) response during two time-limited physical workouts using linear and nonlinear methods. A total of 20 healthy volunteers performed two physical workouts lasting 5 (P5) and 10 min (P10). In both workouts, volunteers performed as many repetitions as possible within the time limit of sets of 10 repetitions of four different exercises in the order of pull-ups, push-ups, barbell power clean, and barbell shoulder to overhead press. Barbell exercises were performed using a load of 50% of each volunteer's personal record for the jerk lift...
April 16, 2018: Computers in Biology and Medicine
Adriana Cunha Muschner, Fernanda Venzon Varela, Katarina Hazuchova, Stijn Jm Niessen, Álan Gomes Pöppl
Case summary: An 8-year-old male neutered Persian cat was presented with polyuria, polydipsia, polyphagia and muscle weakness associated with a 7 month history of diabetes mellitus (DM). The cat had initially been treated with neutral protamine Hagedorn (NPH) insulin 2 U q12h, followed by porcine lente insulin 2 U q12h and, most recently, 3 U glargine insulin q12h, without improvement of clinical signs. The cat also suffered from concurrent symmetrical bilateral alopecia of thorax and forelimbs, abdominal distension and lethargy...
January 2018: JFMS Open Reports
Jennie Shepheard, Elsa Lapiz, Carla Read, Terri J Jackson
BACKGROUND: The Council of Australian Governments has focused the attention of health service managers and state health departments on a list of hospital-acquired complications (HACs) proposed as the basis of funding adjustments for poor quality of hospital inpatient care. These were devised for the Australian Commission on Safety and Quality in Health Care as a subset of their earlier classification of hospital-acquired complications (CHADx) and designed to be used by health services to monitor safety performance for their admitted patients...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
Jianjun Wu, Zhifeng Tang, Fuzai Lü, Keji Yang
As essential components of a high-speed railway system, switch rails can be easily damaged by sophisticated operating conditions. Therefore, precise online detection for switch rails is necessary. Methods based on ultrasonic guided waves are ideal candidates for structural integrity of the switch rails, which are natural waveguides with irregular cross-sections. However, energy decentralization in the wave propagation severely restricts detectability. Phased array systems have been developed and implemented to steer and focus acoustic energy in waveguides of ordinary cross-sections such as pipes and plates...
April 11, 2018: Ultrasonics
Xi-Juan Lv, Yang Wang, Chen Cai, Shu-Feng Pang, Jia-Bi Ma, Yun-Hong Zhang
Hygroscopicity and volatility of single magnesium acetate (MgAc2 ) aerosol particles at various relative humidities (RHs) are studied by a single-beam optical tweezers, and refractive indices (RIs) and morphology are characterized by cavity enhanced Raman spectroscopy. Gel formation and volatilization of acetate acid (HAc) in MgAc2 droplets are observed. Due to the formation of amorphous gel structure, water transposition in droplets at RH < 50% is significantly impeded on a time scale of 140,000 s...
April 14, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Aynur Gunenc, Lingyan Kong, Ryan J Elias, Gregory R Ziegler
The formation of high amylose corn starch (HACS)-alkylresorcinol (AR) inclusion complexes was demonstrated using HACS and a crude AR extract from rye bran, and was confirmed by complementary characterization techniques. Inclusion complex was extracted using hot 2-propanol/water (3:1), and thirteen different AR homologs were identified in the 2-propanol/water extract. However, this extraction regime was insufficient to remove all guests from the inclusion complexes, but did result in annealing of the V-type crystallinity, yielding an endotherm with higher onset and peak temperatures and dissociation enthalpy...
September 1, 2018: Food Chemistry
Margaret A Miller, David S Bruyette, J Catharine Scott-Moncrieff, Tina Jo Owen, José A Ramos-Vara, Hsin-Yi Weng, Andrea L Vanderpool, Annie V Chen, Linda G Martin, Deidre M DuSold, Sina Jahan
To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ≤2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1-5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors...
January 1, 2018: Veterinary Pathology
Cuicui Wang, Richard M Silverman, Jie Shen, Regis J O'Keefe
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles. At the cellular and molecular level, osteoarthritis (OA) is characterised by alteration from a healthy homoeostatic state towards a catabolic state. Several molecular pathways, including transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) signalling, have been identified as critical players in the pathogenesis and progression of OA...
January 2018: Journal of Orthopaedic Translation
Marzena Mach, Karolina Węder, Katarzyna Hąc-Wydro, Michał Flasiński, Joanna Lewandowska-Lancucka, Kinga Wójcik, Pawel Wydro
An increasing number of bacterial infections and the rise in antibiotic resistance of a number of bacteria speciesforces to search for new antibacterial compounds. The latter facts motivate the investigations presented herein and aimed at studying the influence of a cationic lipid:1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) on model (mono,- and bilayer) membranes. The monolayer experiments involved the analysis of the interactions of EPOPC with bacterial membrane lipids in one component and mixed systems as well as Brewster Angle Microcopy studies...
April 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Dariusz Łaski, Stanisław Hać, Iwona Marek, Jarosław Kobiela, Justyna Kostro, Krystian Adrych, Zbigniew Śledziński
Introduction: Chronic pancreatitis (CP) is an important problem for modern medicine, the healthcare system (Poland - NFZ) and the national insurance system (Poland - ZUS). The chronic nature of the disease, the lack of targeted treatment and the low mortality rate lead to an accumulation of patients who demand expensive treatment, both conservative and invasive. Rising costs in health care are forcing the need for a more cost-effective method of treatment. Aim: The primary aim of this study was to perform a retrospective calculation of costs in both surgical and endoscopic treatment, hospital stay, healthcare, and public insurance of patients suffering from chronic pancreatitis...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Mouloud Bouyoucef, Rodolphe Rakic, Tangni Gómez-Leduc, Thomas Latire, Frédéric Marin, Sylvain Leclercq, Franck Carreiras, Antoine Serpentini, Jean-Marc Lebel, Philippe Galéra, Florence Legendre
The shells of the bivalve mollusks are organo-mineral structures predominantly composed of calcium carbonate, but also of a minor organic matrix, a mixture of proteins, glycoproteins, and polysaccharides. These proteins are involved in mineral deposition and, more generally, in the spatial organization of the shell crystallites in well-defined microstructures. In this work, we extracted different organic shell extracts (acid-soluble matrix, acid-insoluble matrix, water-soluble matrix, guanidine HCl/EDTA-extracted matrix, referred as ASM, AIM, WSM, and EDTAM, respectively) from the shell of the scallop Pecten maximus and studied their biological activities on human articular chondrocytes (HACs)...
April 7, 2018: Marine Biotechnology
Ana Cláudia Lima, Cristina Cunha, Agostinho Carvalho, Helena Ferreira, Nuno M Neves
Arthritic diseases are disabling conditions affecting millions of patients worldwide. Pro-inflammatory cytokines, particularly interleukin-6 (IL-6), plays a crucial role in inflammation and cartilage destruction. Although the beneficial effects of antibody therapy, its efficacy is limited. Therefore, this work proposes the immobilization of antibodies at the surface of biodegradable polymeric nanoparticles (NPs) to capture and neutralize IL-6. Our system is intended to protect, extend and enhance the therapeutic efficacy after delivery...
April 3, 2018: ACS Applied Materials & Interfaces
Julie Lemetayer, Shauna Blois
Many articles published in the past few years have contributed to a better understanding of the use of trilostane in dogs. Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of cortisol and all other steroids. Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, and alopecia X. While trilostane controls most of the clinical signs associated with HAC, abnormalities such as hypertension, hypercoagulability, and proteinuria may persist despite therapy...
April 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Tristan M Cofer, Marie Engelberth, Jurgen Engelberth
Although considerable evidence has accumulated on the defensive activity of plant volatile organic compounds (VOCs) against pathogens and insect herbivores, less is known about the significance of VOCs emitted by plants under abiotic stress. Here we report that green leaf volatiles (GLVs), which were previously shown to prime plant defenses against insect herbivore attack, also protect plants against cold stress (4 °C). We show that the expression levels of several cold stress related genes are significantly upregulated in maize (Zea mays) seedlings treated with physiological concentrations of the GLV, (Z)-3-hexen-1-yl acetate (Z-3-HAC), and that seedlings primed with Z-3-HAC exhibit increased growth and reduced damage after cold stress relative to unprimed seedlings...
March 30, 2018: Plant, Cell & Environment
Andrea Beutner, Beate Scherer, Frank-Michael Matysik
Coupling of two detectors is a powerful tool to enhance the overall analytical performance generating complementary information and overcoming the limitations of the single detectors. In this work, capacitively coupled contactless conductivity detection (C4 D) and electrospray ionization mass spectrometry (ESI-MS) were coupled in conjunction with non-aqueous capillary electrophoresis (NACE). Non-aqueous electrolytes are highly compatible with ESI due to their volatility. Moreover, they exhibit low background conductivity, which is essential for the detection with C4 D...
June 1, 2018: Talanta
Elisa Pesenti, Natalay Kouprina, Mikhail Liskovykh, Joan Aurich-Costa, Vladimir Larionov, Hiroshi Masumoto, William C Earnshaw, Oscar Molina
It is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity. However, the pathways leading to the formation and maintenance of centromere chromatin remain poorly characterized due to difficulties of analysis of centromeric repeats in native chromosomes. To address this problem, in our previous studies we generated a human artificial chromosome (HAC) whose centromere contains a synthetic alpha-satellite (alphoid) DNA array containing the tetracycline operator, the alphoidtetO-HAC...
March 22, 2018: ACS Synthetic Biology
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