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https://www.readbyqxmd.com/read/29351556/testosterone-induced-benign-prostatic-hyperplasia-rat-and-dog-as-facile-models-to-assess-drugs-targeting-lower-urinary-tract-symptoms
#1
Jing Li, Yanxin Tian, Shimeng Guo, Haifeng Gu, Qianting Yuan, Xin Xie
Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, α1-adrenergic receptor (α1-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH...
2018: PloS One
https://www.readbyqxmd.com/read/29343977/cost-effectiveness-analysis-of-six-therapies-for-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#2
James C Ulchaker, Melissa S Martinson
Objective: To conduct a cost-effectiveness analysis from payers' perspectives of six treatments for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and to examine positioning of these modalities in the marketplace for the best use of health care funds and quality-of-life benefits for patients. Methods: The economic analysis was conducted with a Markov model to compare combination prescription drug therapy (ComboRx), minimally invasive therapies (MITs) including convective radiofrequency (RF) water vapor thermal therapy (Rezūm®), conductive RF thermal therapy (Prostiva®), and prostatic urethral lift (UroLift®), and invasive surgical procedures including photovaporization of the prostate (Greenlight® PVP) and transurethral resection of the prostate (TURP)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29341501/tadalafil-improves-symptoms-erectile-function-and-quality-of-life-in-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-kyu-pro-study
#3
Ryosuke Takahashi, Minoru Miyazato, Hisae Nishii, Yasuhiro Sumino, Kazuo Takayama, Masako Onzuka, Takuma Oshiro, Seiichi Saito, Naohiro Fujimoto, Hiromitsu Mimata, Masatoshi Eto
OBJECTIVES: Effect of tadalafil on lower urinary tract symptoms (LUTS), erectile function and quality of life (QoL) were prospectively evaluated in patients with benign prostatic hyperplasia (BPH) at multicenter. METHODS: Eligible men were ≥40 years who had no treatment with alpha-blocker for BPH, with total International Prostate Symptom Score (IPSS) ≥8, IPSS-QOL ≥2 and prostate volume ≥20 mL. Data were collected on age, body mass index (BMI), and prostate specific antigen (PSA)...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29316005/tamsulosin-and-the-risk-of-dementia-in-older-men-with-benign-prostatic-hyperplasia
#4
Yinghui Duan, James J Grady, Peter C Albertsen, Z Helen Wu
PURPOSE: Clinicians use tamsulosin, an α1-adrenoceptor antagonist, to manage symptomatic benign prostatic hyperplasia (BPH). Because α1-adrenoceptors are also present in the brain, the potential exists for adverse effects on cognitive functions. We explored the association between tamsulosin use and dementia risk. METHODS: We used Medicare data (2006-2012) to conduct a cohort study among patients aged ≥65 years and diagnosed with BPH. Men taking tamsulosin (n = 253 136) were matched at a 1:1 ratio using propensity-scores to each of 6 comparison cohorts: patients who used no BPH-medication (n = 180 926), and patients who used the following alternative-BPH-medications: doxazosin (n = 28 581), terazosin (n = 23 858), alfuzosin (n = 17 934), dutasteride (n = 34 027), and finasteride (n = 38 767)...
January 9, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29282358/convective-radiofrequency-water-vapor-thermal-therapy-for-benign-prostatic-hyperplasia-a-single-office-experience
#5
Daniel Mollengarden, Kenneth Goldberg, Daniel Wong, Claus Roehrborn
BACKGROUND: Convective radiofrequency water vapor thermal therapy with the Rezūm system is a relatively new treatment for benign prostatic hyperplasia (BPH). We present results from a single surgeon in an office setting. METHODS: A retrospective review of 129 patients from a single surgeon who underwent the Rezūm procedure was performed. All patients were at least 4 months out from treatment. International prostate symptom scores (IPSS), maximum flow rates (Qmax), residual urine volumes, medication usage, and adverse events were monitored...
December 27, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29273728/allopurinol-and-risk-of-benign-prostatic-hyperplasia-in-a-finnish-population-based-cohort
#6
Ville Kukko, Antti Kaipia, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen, Teemu J Murtola
BACKGROUND: Metabolic syndrome and obesity are linked with hyperuricemia, and it has also been proposed that oxidative stress associated with hyperuricemia may promote benign prostatic hyperplasia (BPH). However, it is currently unknown whether use of antihyperuricemic medication is associated with risk of developing BPH. We studied the association between BPH and use of antihyperuricemic allopurinol in a Finnish population-based cohort. METHODS: The study cohort consisted of 74,754 men originally identified for the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC)...
December 22, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29248723/iodine-prevents-the-increase-of-testosterone-induced-oxidative-stress-in-a-model-of-rat-prostatic-hyperplasia
#7
Michelle Quintero-García, Evangelina Delgado-González, Ana Sánchez-Tusie, Mario Vázquez, Carmen Aceves, Brenda Anguiano
Oxidative stress and inflammation are involved in the development and/or progression of benign prostatic hyperplasia (BPH). Molecular iodine (I2) induces antiproliferative and apoptotic effects in prostate cancer cells, but it is unknown if I2 regulates oxidative stress in the normal and/or tumoral prostate. The purpose of this study was to analyze the effects of I2 and celecoxib (Cxb) on oxidative stress and inflammation in a model of prostatic hyperplasia. Cxb was used as positive control of cyclooxygenase-2 (COX-2) inhibition...
December 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29234244/genetic-alterations-in-benign-prostatic-hyperplasia-patients
#8
Hanaa Mahmoud Mohamed, Magdy Sayed Aly, Tarek Dardeer Hussein
Background: Benign prostate hyperplasia (BPH) is a classical age-related disease of the prostate, present in 20% of men at the age of 40 years with progression to 70% by the age of 60 years. BPH is associated with various lower urinary tract symptoms, which affect their day-to-day life. Materials and methods: Our objective was to evaluate the association between HER-2/neu, c-myc, p53, and clinicopathological variables in 45 patients diagnosed with benign prostatic hyperplasia using fluorescence in situ hybridization (FISH)...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#9
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29191671/erectile-dysfunction-and-lower-urinary-tract-symptoms
#10
REVIEW
Cosimo De Nunzio, Claus G Roehrborn, Karl-Erik Andersson, Kevin T McVary
CONTEXT: Lower urinary tract symptoms (LUTSs) and erectile dysfunction (ED) are substantial health concerns with a significant impact on the overall male quality of life. OBJECTIVE: To evaluate the available evidence of the association between LUTSs and ED in patients with benign prostatic hyperplasia (BPH), and discuss possible clinical implications for the management of LUTS/BPH. EVIDENCE ACQUISITION: A systematic review of the existing literature published between 1997 and June 2017 and available in the Medline, Scopus, and Web of Science databases was conducted using both the Medical Subject Heading (MeSH) and free-text protocols...
November 27, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29188203/comparison-of-visual-prostate-symptom-score-and-international-prostate-symptom-score-in-the-evaluation-of-men-with-benign-prostatic-hyperplasia-a-prospective-study-from-an-indian-population
#11
Yogesh Taneja, Priyatama Ram, Satish Kumar, Kishan Raj, Charan K Singh, Santosh K Dhaked, Jiten Jaipuria
Background: Lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) are common conditions in middle-age or older men. The International Prostate Symptom Score (IPSS) is a useful and validated questionnaire to evaluate LUTS secondary to BPH. Van der Walt et al have developed an alternative questionnaire named the Visual Prostate Symptom Score (VPSS) questionnaire. This study aimed to evaluate the relationship between the VPSS and IPSS in the evaluation of men with LUTSs due to BPH in an Indian population...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29138929/safety-and-feasibility-study-of-holmium-laser-enucleation-of-the-prostate-holep-on-patients-receiving-dual-antiplatelet-therapy-dapt
#12
Jie Sun, An Shi, Zhen Tong, Wei Xue
OBJECTIVE: To evaluate the safety and feasibility of Holmium laser enucleation of the prostate (HoLEP) in patients receiving dual antiplatelet therapy (DAPT). METHODS: From March 2013 to August 2016, we retrospectively analyzed 1124 benign prostatic hyperplasia (BPH) patients undergoing HoLEP and divided into four groups: 56 cases receiving DAPT therapy (group A); 72 patients treated with continuous single antiplatelet (AP) therapy (group B); 41 patients treated with single AP therapy but intermittent during preoperative time (group C) and 955 cases had no AP therapy (group D)...
November 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29128994/radiologists-preferences-regarding-content-of-prostate-mri-reports-a-survey-of-the-society-of-abdominal-radiology
#13
Benjamin Spilseth, Daniel J Margolis, Sangeet Ghai, Nayana U Patel, Andrew B Rosenkrantz
PURPOSE: To evaluate radiologist preferences regarding specific content that warrants inclusion in prostate MRI reports. METHODS: Sixty-one members of the Society of Abdominal Radiology responded to a 74-item survey regarding specific content warranted in prostate MRI reports, conducted in August 2016. RESULTS: General items deemed essential report content by ≥ 50% of respondents were prostate volume (80%), extent of prostate hemorrhage (74%), TURP defects (69%), coil type (64%), BPH (61%), contrast dose (61%), contrast agent (59%), medications administered (59%), and magnet strength (54%)...
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29080225/molecular-correlates-in-urine-for-the-obesity-and-prostatic-inflammation-of-bph-luts-patients
#14
Pradeep Tyagi, Saundra S Motley, Tatsuki Koyama, Mahendra Kashyap, Jeffrey Gingrich, Naoki Yoshimura, Jay H Fowke
PURPOSE: Benign prostatic hyperplasia (BPH) is strongly associated with obesity and prostatic tissue inflammation, but the molecular underpinning of this relationship is not known. Here, we examined the association between urine levels of chemokines/adipokines with histological markers of prostate inflammation, obesity, and lower urinary tract symptoms LUTS in BPH patients. METHODS: Frozen urine specimens from 207 BPH/LUTS patients enrolled in Nashville Men's Health Study were sent for blinded analysis of 11 analytes, namely sIL-1RA, CXC chemokines (CXCL-1, CXCL-8, CXCL-10), CC chemokines (CCL2, CCL3, CCL5), PDGF-BB, interleukins IL-6, IL-17, and sCD40L using Luminex™ xMAP® technology...
October 27, 2017: Prostate
https://www.readbyqxmd.com/read/29048765/ageratum-conyzoides-l-inhibits-5-alpha-reductase-gene-expression-in-human-prostate-cells-and-reduces-symptoms-of-benign-prostatic-hypertrophy-in-otherwise-healthy-men-in-a-double-blind-randomized-placebo-controlled-clinical-study
#15
Matthew Detering, Elizabeth Steels, Sundar Rao Koyyalamudi, Elena Allifranchini, Elena Bocchietto, Luis Vitetta
A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR)...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/28977110/contemporary-surgical-treatment-of-benign-prostatic-hyperplasia
#16
Ricardo Luís Vita Nunes, Alberto Azoubel Antunes, Davi Souza Constantin
Benign prostatic hyperplasia (BPH) is a common condition in adult men and its incidence increases progressively with aging. It has an important impact on the individual's physical and mental health and its natural progression can lead to serious pathological situations. Although the initial treatment is pharmacological, except in specific situations, the tendency of disease progression causes a considerable portion of the patients to require surgical treatment. In this case, there are several options available today in the therapeutic armamentarium...
August 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28976344/-laparoscopic-adenomectomy-evolution-of-the-technique-and-results
#17
Alejandro Garcia-Segui
OBJECTIVE: Laparoscopic adenomectomy (LA) is an effective procedure for the treatment of benign prostatic hyperplasia (BPH), which reproduces the surgical steps of the open adenomectomy (OA) by a minimally invasive approach to obtain the favorable results of open surgery in combination with the benefits offered by laparoscopic techniques. We performed a comprehensive bibliographic review of the technique and its current results in order to describe the evolution of the surgical technique and present the current evidence on the LA...
October 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28948696/benign-prostatic-hyperplasia-long-term-follow-up-of-prostate-volume-reduction-after-sclerotherapy-of-the-internal-spermatic-veins
#18
Y Gat, M Goren
The purpose was to examine the results of bilateral percutaneous sclerotherapy of the internal spermatic veins on prostate volume and prostatic symptoms. We previously showed that destruction of one-way valves in the internal spermatic veins (varicocele) elevates hydrostatic pressure in the vertical testicular venous drainage system in the erect human. This diverts free testosterone (FT) flow at high concentrations directly from the testes into the prostate. High intraprostatic FT prolongs prostate cell life and increases cell proliferation rate-synergistic effects resulting in increased cell population (BPH)...
September 25, 2017: Andrologia
https://www.readbyqxmd.com/read/28940538/androgenic-to-estrogenic-switch-in-human-adult-prostate-gland-is-regulated-by-epigenetic-silencing-of-steroid-5%C3%AE-reductase-2
#19
Zongwei Wang, Libing Hu, Keyan Salari, Seth Bechis, Rongbin Ge, Shulin Wu, Cyrus Rassoulian, Jonathan Pham, Chin-Lee Wu, Shahin Tabatabaei, Strand W Douglas, Aria F Olumi
Benign prostatic hyperplasia (BPH) is the most common proliferative abnormality of the prostate. While all men experience some prostate growth as they age, the rate of growth varies among individuals. Steroid 5α-reductase 2 (SRD5A2) is a critical enzyme for prostatic development and growth. Previous work indicates that one-third of adult prostate samples do not express SRD5A2, secondary to epigenetic modifications. Here we show that estradiol is dramatically elevated, concomitant with significantly upregulated estrogen response genes, in prostate samples that are methylated at the SRD5A2 promoter...
September 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28934186/opioid-overdose-outbreak-west-virginia-august-2016
#20
Joel Massey, Michael Kilkenny, Samantha Batdorf, Sarah K Sanders, Debra Ellison, John Halpin, R Matthew Gladden, Danae Bixler, Loretta Haddy, Rahul Gupta
On August 15, 2016, the Mayor's Office of Drug Control Policy in Huntington, West Virginia, notified the Cabell-Huntington Health Department (CHHD) of multiple calls regarding opioid overdose received by the emergency medical system (EMS) during 3 p.m.-8 p.m. that day. A public health investigation and response conducted by the West Virginia Bureau for Public Health (BPH) and CHHD identified 20 opioid overdose cases within a 53-hour period in Cabell County; all cases included emergency department (ED) encounters...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
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