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P N Durrington
The study assesses whether diabetes has an effect on serum high density lipoprotein (HDL) cholesterol concentration independent of other factors known to influence serum HDL cholesterol concentration. Concentrations of serum HDL cholesterol, serum cholesterol, serum M particles and blood sugar, and the proportion of haemoglobin in the form of HbA1 were measured in a diabetic and a non-diabetic polulation. Relative body weight, alcohol and cigarette consumption, age, a clinical estimate of diabetic control and duration of disbetes were also recorded...
May 21, 1980: Clinica Chimica Acta; International Journal of Clinical Chemistry
S C Kalhan, S M Savin, P A Adam
Glucose turnover was measured in normal and disbetic dogs by the dilution of glucose-1-13C and glucose-1-14C tracers infused simultaneously at constant rates. In order to quantify the stable isotope, an enzymatic assay for the analysis of glucose-1-13C was developed and evaluated. CO2 from C-1 glucose was evolved by coupling hexokinase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconic dehydrogenase activities. The 13C/12C ratio of the CO2 was measured with a high-precision magnetic-deflection double-collector mass spectrometer, and the radioactivity of 14CO2 was quantified by liquid scintillation...
February 1977: Journal of Laboratory and Clinical Medicine
J Pedersen, L M Mølsted-Pedersen
A consecutive and prospective series comprising 949 newborn infants of diabetic mothers treated during pregnancy and delivery in the period 1966--1977 has been analysed. The malformation rate was 8.2%. As compared to infants of mothers (White classes B-F alone) controlled outside pregnancy elsewhere, the rate of malformations was significantly reduced (from 14.1 to 7.4%) in fants whose mothers attended two hospitals specializing in the treatment and ambulatory control of diabetics. For diabetics not controlled at a diabetic centre outside pregnancy the malformation rate was 9% in classes B + C and 19...
March 30, 1978: Ciba Foundation Symposium
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