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https://www.readbyqxmd.com/read/27494608/high-prevalence-of-anti-hepatitis-e-virus-antibodies-among-blood-donors-in-central-italy-february-to-march-2014
#1
Claudia Lucarelli, Enea Spada, Gloria Taliani, Paola Chionne, Elisabetta Madonna, Cinzia Marcantonio, Patrizio Pezzotti, Roberto Bruni, Giuseppina La Rosa, Giulio Pisani, Luigi Dell'Orso, Katia Ragone, Carla Tomei, Anna Rita Ciccaglione
Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2...
July 28, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27308223/an-artificial-molecular-transporter
#2
Christian Schäfer, Giulio Ragazzon, Benoit Colasson, Marcello La Rosa, Serena Silvi, Alberto Credi
The transport of substrates is one of the main tasks of biomolecular machines in living organisms. We report a synthetic small-molecule system designed to catch, displace, and release molecular cargo in solution under external control. The system consists of a bistable rotaxane that behaves as an acid-base controlled molecular shuttle, whose ring component bears a tether ending with a nitrile group. The latter can be coordinated to a ruthenium complex that acts as the load, and dissociated upon irradiation with visible light...
April 2016: ChemistryOpen
https://www.readbyqxmd.com/read/26930580/evaluation-of-rapid-tests-for-diagnosis-of-acute-hepatitis-e
#3
Paola Chionne, Elisabetta Madonna, Giulio Pisani, Stefania Taffon, Giuseppina La Rosa, Angela Candido, Stefano Dettori, Elena Tritarelli, Michele Equestre, Roberto Bruni, Anna Rita Ciccaglione
BACKGROUND: Hepatitis E virus diagnosis still presents difficulties due to discordant results among diagnostic tests. OBJECTIVES: The aim of this study was to evaluate the performance of two rapid tests for detection of anti-HEV IgM antibodies. STUDY DESIGN: The rapid tests were compared with three commercial anti-HEV ELISA assays and one Real-Time PCR assay on 59 sera from patients with acute viral non-AC hepatitis. RESULTS: The presence of anti-HEV IgM antibodies was evaluated by two rapid tests (Wantai and Assure) on 25 HEV RNA positive samples...
May 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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