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https://www.readbyqxmd.com/read/29045076/outside-in-hla-class-i-signaling-regulates-icam-1-clustering-and-endothelial-monocyte-interactions-via-mtor-in-transplant-antibody-mediated-rejection
#1
Sahar Salehi, Rebecca A Sosa, Yi-Ping Jin, Shoichi Kageyama, Michael C Fishbein, Enrique Rozengurt, Jerzy W Kupiec-Weglinski, Elaine F Reed
Antibody-mediated rejection (AMR) resulting in transplant allograft vasculopathy (TAV) is the major obstacle for long-term survival of solid organ transplants. AMR is caused by donor-specific antibodies to HLA which contribute to TAV by initiating outside-in signaling transduction pathways that elicit monocyte recruitment to activated endothelium. Mechanistic target of rapamycin (mTOR) inhibitors can attenuate TAV; therefore, we sought to understand the mechanistic underpinnings of mTOR signaling in HLA class I Ab-mediated endothelial cell activation and monocyte recruitment...
October 17, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29044085/vitrectomy-for-epiretinal-membrane-in-adult-onset-coats-disease
#2
Pradeep Kumar, Vinod Kumar
Coats' disease is characterized by retinal vascular telangiectasia and subretinal and intraretinal exudation. A relatively benign form of the disease that occurs in adults is referred to as adult-onset Coats' disease. Involvement of macula in the form of macular edema and exudation are the common presenting features in both forms of the disease. We describe a rare case of adult-onset Coats' disease that presented with epiretinal membrane (ERM). Laser photocoagulation of retinal vascular telangiectasia resulted in worsening of patient's symptoms and ERM...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043565/eccentric-macular-hole-after-pars-plana-vitrectomy-for-epiretinal-membrane-without-internal-limiting-membrane-peeling-a-case-report
#3
Christina Garnavou-Xirou, Tina Xirou, Stamatina Kabanarou, Ilias Gkizis, Stavros Velissaris, Irini Chatziralli
INTRODUCTION: Postoperative eccentric macular hole formation is an uncommon complication after pars plana vitrectomy (PPV) without internal limiting membrane (ILM) peeling for the treatment of epiretinal membrane (ERM). We present a case of eccentric macular hole formation after PPV for ERM without ILM peeling. CASE REPORT: A 68-year-old male patient presented with ERM and visual acuity of 6/24 in his left eye. He underwent 23-gauge PPV without ILM peeling for treatment of ERM...
October 17, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29041475/sub-shot-noise-shadow-sensing-with-quantum-correlations
#4
Ermes Toninelli, Matthew P Edgar, Paul-Antoine Moreau, Graham M Gibson, Giles D Hammond, Miles J Padgett
The quantised nature of the electromagnetic field sets the classical limit to the sensitivity of position measurements. However, techniques based on the properties of quantum states can be exploited to accurately measure the relative displacement of a physical object beyond this classical limit. In this work, we use a simple scheme based on the split-detection of quantum correlations to measure the position of a shadow at the single-photon light level, with a precision that exceeds the shot-noise limit. This result is obtained by analysing the correlated signals of bi-photon pairs, created in parametric downconversion and detected by an electron multiplying CCD (EMCCD) camera employed as a split-detector...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29037497/comparative-toxicities-of-silver-nitrate-silver-nanocolloids-and-silver-chloro-complexes-to-japanese-medaka-embryos-and-later-effects-on-population-growth-rate
#5
Chisato Kataoka, Yumie Kato, Tadashi Ariyoshi, Masaki Takasu, Takahito Narazaki, Seiji Nagasaka, Haruki Tatsuta, Shosaku Kashiwada
Fish embryo toxicology is important because embryos are more susceptible than adults to toxicants. In addition, the aquatic toxicity of chemicals depends on water quality. We examined the toxicities to medaka embryos of three types of silver-AgNO3, silver nanocolloids (SNCs), and silver ions from silver nanoparticle plates (SNPPs)-under three pH conditions (4.0, 7.0, and 9.0) in embryo-rearing medium (ERM) or ultrapure water. Furthermore, we tested the later-life-stage effects of SNCs on medaka and their population growth...
October 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29037124/effects-of-different-wastewater-characteristics-and-treatment-techniques-on-the-bacterial-community-structure-in-three-pharmaceutical-wastewater-treatment-systems
#6
Erming Ouyang, Yuan Liu, Jiating Ouyang, Xiaohui Wang
Pharmaceutical wastewater is a typical type of wastewater with high concentrations of organic pollutants, but research on this subject is limited. The microbial community structure of sludge samples collected from the aeration tanks of three different pharmaceutical wastewater treatment systems was investigated using high-throughput sequencing. The three aeration tanks were seeded with the same inocula and stably operated for 40 days. Then, aerobic sludge samples from the three aeration tanks were collected to provide insight into the bacterial community composition of the activated sludges...
October 16, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29030312/antimicrobial-resistance-of-enterococcus-spp-isolated-from-thai-fermented-pork-in-chiang-rai-province-thailand
#7
Kamonnaree Chotinantakul, Nittaya Chansiw, Seiji Okada
OBJECTIVES: The aim of this study is to evaluate the prevalence of resistant phenotypes and genes of Enterococcus spp. to explore the range of resistant profiles from Thai traditional fermented pork. METHODS: A total of 120 Thai fermented pork specimens in Chiang Rai, Thailand were collected and antimicrobial resistance was identified using 11 antimicrobial agents in enterococcal isolates, via an agar disk diffusion method. The antibiotic resistant genes from resistant phenotypes and virulence genes were observed...
October 10, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29028569/occurrence-of-transferable-antibiotic-resistances-in-commercialized-ready-to-eat-mealworms-tenebrio-molitor-l
#8
Andrea Osimani, Federica Cardinali, Lucia Aquilanti, Cristiana Garofalo, Andrea Roncolini, Vesna Milanović, Marina Pasquini, Stefano Tavoletti, Francesca Clementi
The present study aimed to assess the occurrence of transferable determinants conferring resistance to tetracyclines, macrolide-lincosamide-streptogramin B, vancomycin, beta-lactams, and aminoglycosides in 40 samples of commercialized edible mealworms (Tenebrio molitor L.) purchased from European Union (EU) and non-EU producers. A high prevalence of tet(K) was observed in all of the samples assayed, with percentages of PCR-based positivity that ranged from 80% (samples from Thailand) to 100% (samples from the Netherlands, Belgium and France)...
October 5, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29022294/epiretinal-membrane-prevalence-and-risk-factors-from-the-korea-national-health-and-nutrition-examination-survey-2008-through-2012
#9
Jong Min Kim, Hoyoung Lee, Jae Pil Shin, Jeeyun Ahn, Je Moon Yoon, Su Jeong Song, Sang Jin Kim, Se Woong Kang
PURPOSE: To investigate the prevalence and risk factors for an epiretinal membrane (ERM) in Korean population. METHODS: Using the database of the Korea National Health and Nutrition Examination Survey from 2008 through 2012, 14,772 participants 40 years of age or older with gradable fundus photographs were included. The presence of ERM was determined by using fundus photographs. The prevalence of ERM was estimated and possible risk factors including systemic factors, nutritional status, and blood tests were analyzed via multiple logistic regression analyses...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29022293/correlation-between-uncorrected-visual-acuity-and-macular-distortion-in-idiopathic-epiretinal-membrane-patients
#10
Jang Hoon Lee, Sung Pyo Park, Yong Kyu Kim
PURPOSE: To evaluate the association between degree of retinal abnormalities and uncorrected visual acuity (UCVA) in idiopathic epiretinal membrane (ERM) patients with a small amount of refractive error. METHODS: We retrospectively reviewed 49 eyes (37 patients) of idiopathic ERM patients. We investigated the association between visual acuity and macular status (central macular thickness [CMT], outer retinal integrity score, and inner retinal irregularity index) that was assessed by optical coherence tomography using multiple linear regression analysis...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29017460/27-gauge-and-25-gauge-vitrectomy-day-surgery-for-idiopathic-epiretinal-membrane
#11
Saigen Naruse, Hiroyuki Shimada, Ryusaburo Mori
BACKGROUND: This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM). METHODS: The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ERM (27-G vitrectomy in 100 eyes and 25-G vitrectomy in 100 eyes) were studied for 6 months. In all eyes, scleral tunnels were made using angle incisions, and air or gas exchange was performed...
October 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28985758/pharmacological-targeting-of-the-ephrin-receptor-kinase-signalling-by-glpg1790-in-vitro-and-in-vivo-reverts-oncophenotype-induces-myogenic-differentiation-and-radiosensitizes-embryonal-rhabdomyosarcoma-cells
#12
Francesca Megiorni, Giovanni Luca Gravina, Simona Camero, Simona Ceccarelli, Andrea Del Fattore, Vincenzo Desiderio, Federica Papaccio, Heather P McDowell, Rajeev Shukla, Antonio Pizzuti, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Roberto Maggio, Francesca De Felice, Cinzia Marchese, Carlo Dominici, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
BACKGROUND: EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines. METHODS: EPH-A2 and Ephrin-A1 mRNA expression was quantified by real-time PCR in 14 ERMS tumour samples and in normal skeletal muscle (NSM). GLPG1790 effects were tested in RD and TE671 cell lines, two in vitro models of ERMS, by performing flow cytometry analysis, Western blotting and immunofluorescence experiments...
October 6, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28985476/in-silico-analysis-of-co-evolution-among-ermes-proteins-pex11-and-lam6
#13
Deborah A Court, Shivani Khetoo, Sabbir Rahman Shuvo, Shayne D Reitmeier, Georg Hausner
In eukaryotic cells communication and dynamic interactions among different organelles are important for maintaining cellular homeostasis. The Endoplasmic-Reticulum (ER) Mitochondria Encounter Structure (ERMES) complex establishes membrane contact sites between ER and mitochondria and is essential for phospholipid transport, protein import and mitochondrial dynamics and inheritance. In this work, in-silico analyses were used to probe the intramolecular interactions in ERMES proteins and the interactions that support the ERMES complex...
October 6, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28979089/long-term-evaluation-of-spontaneous-release-of-epiretinal-membrane-and-its-possible-pathogenesis
#14
Teruyo Kida, Seita Morishita, Masanori Fukumoto, Takaki Sato, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: To investigate the characteristics in spontaneous release of epiretinal membrane (ERM) during watchful waiting and to introduce a possible mechanism of pathogenesis as a photo essay. METHODS: Records from all patients with ERM were obtained from Osaka Medical College Hospital from January 2001 to October 2012. Visual acuity (VA), fundus photo, and optical coherence tomography (OCT) were reviewed using the medical records. For statistical analysis, VA measured with a Landolt chart was converted to the logarithm of the minimum angle of resolution (logMAR)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28978692/the-erm-protein-moesin-regulates-cd8-regulatory-t-cell-homeostasis-and-self-tolerance
#15
Hiroki Satooka, Daisuke Nagakubo, Tomomi Sato, Takako Hirata
The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins that link membrane proteins with actin filaments in the cell cortex and regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. Lymphocytes predominantly express two ERM members, ezrin and moesin. Mutations in the moesin gene in humans are associated with primary immunodeficiency with profound lymphopenia, and moesin-deficient mice exhibit a similar lymphopenia phenotype...
October 4, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28970102/the-proteome-speciation-of-an-immortalized-cystic-fibrosis-cell-line-new-perspectives-on-the-pathophysiology-of-the-disease
#16
Puglia Michele, Landi Claudia, Gagliardi Assunta, Breslin Loretta, Armini Alessandro, Brunetti Jlenia, Pini Alessandro, Bianchi Laura, Bini Luca
Cystic Fibrosis (CF) is a recessively inherited disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR has a pivotal role in the onset of CF, and several proteins are involved in its homeostasis. To study CFTR interactors at protein species level, we used a functional proteomics approach combining 2D-DIGE, mass spectrometry and enrichment analysis. A human bronchial epithelial cell line with cystic fibrosis (CFBE41o-) and the control (16HBE14o-) were used for the comparison...
September 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28968964/preclinical-testing-of-the-glycogen-synthase-kinase-3%C3%AE-inhibitor-tideglusib-for-rhabdomyosarcoma
#17
Narendra Bharathy, Matthew N Svalina, Teagan P Settelmeyer, Megan M Cleary, Noah E Berlow, Susan D Airhart, Sunny Xiang, James Keck, James B Hayden, Jack F Shern, Atiya Mansoor, Melvin Lathara, Ganapati Srinivasa, David M Langenau, Charles Keller
Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. RMS often arise from myogenic precursors and displays a poorly differentiated skeletal muscle phenotype most closely resembling regenerating muscle. GSK3β is a ubiquitously expressed serine-threonine kinase capable of repressing the terminal myogenic differentiation program in cardiac and skeletal muscle. Recent unbiased chemical screening efforts have prioritized GSK3β inhibitors as inducers of myodifferentiation in RMS, suggesting efficacy as single agents in suppressing growth and promoting self-renewal in zebrafish transgenic embryonal RMS (eRMS) models in vivo...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967076/aflibercept-in-the-management-of-acute-retinal-necrosis-syndrome-related-macular-edema
#18
Leticia Ortega-Evangelio, Javier Navarrete-Sanchis, Basil K Williams, Juan Miguel Tomás-Torrent
PURPOSE: Acute retinal necrosis (ARN) is a panuveitis syndrome that may lead to severe complications such as cystoid macular edema (CME). There is no consensus about the best treatment. We report one case of CME secondary to ARN managed with intravitreal aflibercept. CASE REPORT: A 41-year-old woman with a history of successfully treated varicella-zoster virus-associated ARN developed an epiretinal membrane (ERM) and underwent pars plana vitrectomy, ERM removal, inner limiting membrane peel, and lensectomy...
September 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28961986/novel-multiresistance-cfr-plasmids-in-linezolid-resistant-methicillin-resistant-staphylococcus-epidermidis-and-vancomycin-resistant-enterococcus-faecium-vre-from-a-hospital-outbreak-co-location-of-cfr-and-optra-in-vre
#19
Alexandros Lazaris, David C Coleman, Angela M Kearns, Bruno Pichon, Peter M Kinnevey, Megan R Earls, Breida Boyle, Brian O'Connell, Gráinne I Brennan, Anna C Shore
Background: Linezolid is often the drug of last resort to treat infections caused by Gram-positive cocci. Linezolid resistance can be mutational (23S rRNA or L-protein) or, less commonly, acquired [predominantly cfr , conferring resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A compounds (PhLOPS A ) or optrA , encoding oxazolidinone and phenicol resistance]. Objectives: To investigate the clonality and genetic basis of linezolid resistance in 13 linezolid-resistant (LZDR) methicillin-resistant Staphylococcus epidermidis (MRSE) isolates recovered during a 2013/14 outbreak in an ICU in an Irish hospital and an LZDR vancomycin-resistant Enterococcus faecium (VRE) isolate from an LZDR-MRSE-positive patient...
August 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28961896/expression-of-acquired-macrolide-resistance-genes-in-haemophilus-influenzae
#20
Christopher T Atkinson, Dale A Kunde, Stephen G Tristram
Objectives: To investigate the phenotypic effect of expression of selected acquired macrolide resistance genes (AMRGs) in non-typeable Haemophilus influenzae (NTHi). Methods: The AMRGs erm (A), erm (B) and erm (C) were cloned into Escherichia coli JM109 using the shuttle vector pLS88; constructed plasmids extracted from suitable clones were used to transform H. influenzae Rd by electroporation. Erythromycin and azithromycin MICs for suitable transformants were determined by broth microdilution...
August 23, 2017: Journal of Antimicrobial Chemotherapy
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