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Mark A P Fajgenbaum, Roger S Wong, David A H Laidlaw, Tom H Williamson
Purpose: To determine the long-term incidence of fellow-eye surgical involvement in patients who have undergone first-eye vitreoretinal (VR) surgery for a variety of indications. This was a single-institution retrospective, consecutive series. Methods: Eighteen years of electronic surgical data were reviewed at our institution. All patients having surgery for the following indications were included: rhegmatogenous retinal detachment (RRD), macular hole (MH), epiretinal membrane (ERM), proliferative diabetic retinopathy (PDR), vitritis, and dropped nucleus...
May 2018: Indian Journal of Ophthalmology
Meiju Luo, Yan Zhang
In this paper, we consider stochastic second-order-cone complementarity problems (SSOCCP). We first use the so-called second-order-cone complementarity function to present an expected residual minimization (ERM) model for giving reasonable solutions of SSOCCP. Then, we introduce a smoothing function, by which we obtain a smoothing approximate ERM model. We further show that the global solution sequence and weak stationary point sequence of this smoothing approximate ERM model converge to the global solution and the weak stationary point of the original ERM model as the smoothing parameter tends to zero respectively...
2018: Journal of Inequalities and Applications
Robert Kromer, Clara Vogt, Lars Wagenfeld, Martin Stephan Spitzer, Birthe Stemplewitz
Introduction Idiopathic epiretinal membrane (ERM) is a proliferation of cells formed on the internal surface of the retina and may cause a slow decrease in visual acuity (VA). The aim of this study was to evaluate the individual layers of the retina by optical coherence tomography (OCT) before and after vitrectomy with ERM peeling in order to refine surgical decision-making. Methods Forty-seven eyes of 45 patients (aged 55-87 years) with ERM were enrolled retrospectively from a tertiary referral centre. OCT examination was performed preoperatively and at a mean of 3...
April 19, 2018: Current Eye Research
Yuriko Kakimoto, Shinya Tashiro, Rieko Kojima, Yuki Morozumi, Toshiya Endo, Yasushi Tamura
Functional integrity of eukaryotic organelles relies on direct physical contacts between distinct organelles. However, the entity of organelle-tethering factors is not well understood due to lack of means to analyze inter-organelle interactions in living cells. Here we evaluate the split-GFP system for visualizing organelle contact sites in vivo and show its advantages and disadvantages. We observed punctate GFP signals from the split-GFP fragments targeted to any pairs of organelles among the ER, mitochondria, peroxisomes, vacuole and lipid droplets in yeast cells, which suggests that these organelles form contact sites with multiple organelles simultaneously although it is difficult to rule out the possibilities that these organelle contacts sites are artificially formed by the irreversible associations of the split-GFP probes...
April 18, 2018: Scientific Reports
Jocelyn M Choo, Guy C J Abell, Rachel Thomson, Lucy Morgan, Grant Waterer, David L Gordon, Steven L Taylor, Lex E X Leong, Steve L Wesselingh, Lucy D Burr, Geraint B Rogers
Long-term macrolide therapy reduces rates of pulmonary exacerbation in bronchiectasis. However, little is known about the potential for macrolide therapy to alter the composition and function of the oropharyngeal commensal microbiota or to increase the carriage of transmissible antimicrobial resistance. We assessed the effect of long-term erythromycin on oropharyngeal microbiota composition and the carriage of transmissible macrolide resistance genes in 84 adults with bronchiectasis, enrolled in the Bronchiectasis and Low-dose Erythromycin Study (BLESS) 48-week placebo-controlled trial of twice-daily erythromycin ethylsuccinate (400 mg)...
April 25, 2018: MSphere
Yvonne T Kschonsak, Ingrid Hoffmann
Correct spindle orientation is achieved through signaling pathways that provide a molecular link between the cell cortex and spindle microtubules in an F-actin dependent manner. A conserved cortical protein complex, composed of LGN, NuMA, dynein-dynactin, plays a key role in establishing proper spindle orientation. It has also been shown that the actin-binding protein MISP and the ERM family, that are activated by LOK/SLK in mitosis, regulate spindle orientation. Here, we report that MISP functions between the ERM family member Ezrin and NuMA to allow optimal spindle positioning...
April 18, 2018: Journal of Cell Science
Marilyn C Roberts, Prabhu Raj Joshi, Alexander L Greninger, Daira Melendez, Saroj Paudel, Mahesh Acharya, Nabin Kishor Bimali, Narayan P Koju, David No, Mukesh Chalise, Randall C Kyes
Swine nasal samples [n = 282] were collected from 12 randomly selected farms around Kathmandu, Nepal, from healthy animals. In addition, wild monkey (Macaca mulatta) saliva samples [n = 59] were collected near temples areas in Kathmandu using a non-invasive sampling technique. All samples were processed for MRSA using standardized selective media and conventional biochemical tests. MRSA verification was done and isolates characterized by SCCmec, multilocus sequence typing, whole genome sequencing [WGS] and antibiotic susceptibilities...
May 1, 2018: FEMS Microbiology Ecology
Justis P Ehlers, Mehnaz Khan, Daniel Petkovsek, Laura Stiegel, Peter K Kaiser, Rishi P Singh, Jamie L Reese, Sunil K Srivastava
Purpose: To assess the retinal architecture changes which occur during epiretinal membrane (ERM) surgery, utilizing intraoperative optical coherence tomography ( i OCT). Design: Prospective multi-surgeon single center study. Subjects/Participants: Subjects from the PIONEER i OCT study who underwent surgical intervention for management of ERM. Methods: All subjects underwent vitrectomy with ERM peeling with optional internal limiting membrane (ILM) peeling...
April 2018: Ophthalmology Retina
Yunfei Wang, Mengmeng Liu, Shijian Deng, Xin Sui, Linlin Fan, Qi Zhang
Epithelial rests of Malassez (ERM), the only odontogenic epithelial structures in periodontal tissue, are proposed to correlate with root resorption, but the detailed mechanism remains unclear. Osteoprotegerin (OPG), the main inhibitor of osteoclastogenesis, plays a pivotal role in inhibiting root resorption, and ERM cells express OPG mRNA in vitro. Thus, in this study, we aimed to clarify OPG expression in ERM in vivo and to explore the role of OPG in ERM to determine whether ERM are associated with root resorption via OPG...
April 11, 2018: Journal of Molecular Histology
Shuting Li, Xiangning Wang, Xinhua Du, Qiang Wu
To compare the visualization of the lesions of diabetic retinopathy (DR) using multicolour scanning laser imaging (MSLI) and conventional colour fundus photography (CFP). The paired images of diabetic patients who underwent same-day MSLI and CFP examinations were reviewed. Combined multicolour (MC) images were acquired simultaneously using three laser wavelengths: blue reflectance (BR, λ = 488 nm), green reflectance (GR, λ = 518 nm) and infrared reflectance (IR, λ = 820 nm). The number of positive DR lesions was calculated using fundus fluorescein angiography as the reference standard...
April 7, 2018: Lasers in Medical Science
Elisabeth Tamayo, Simon A B Knight, Ascensión Valderas, Andrew Dancis, Nuria Ferrol
Arbuscular mycorrhizal (AM) fungi can improve iron (Fe) acquisition of their host plants. Here, we report a characterization of two components of the high-affinity reductive Fe uptake system of Rhizophagus irregularis, the ferric reductase (RiFRE1) and the high affinity Fe permeases (RiFTR1-2). In the extraradical mycelia (ERM), Fe deficiency induced activation of a plasma membrane-localized ferric reductase, an enzyme that reduces Fe(III) sources to the more soluble Fe(II). Yeast mutant complementation assays showed that RiFRE1 encodes a functional ferric reductase and RiFTR1 an iron permease...
April 6, 2018: Environmental Microbiology
Krishna Chinthalapudi, Vinay Mandati, Jie Zheng, Andrew J Sharff, Gerard Bricogne, Patrick R Griffin, Joseph Kissil, Tina Izard
Neurofibromatosis type 2 (NF2) is a tumor-forming disease of the nervous system caused by deletion or by loss-of-function mutations in NF2, encoding the tumor suppressing protein neurofibromin 2 (also known as schwannomin or merlin). Neurofibromin 2 is a member of the ezrin, radixin, moesin (ERM) family of proteins regulating the cytoskeleton and cell signaling. The correlation of the tumor-suppressive function and conformation (open or closed) of neurofibromin 2 has been subject to much speculation, often based on extrapolation from other ERM proteins, and controversy...
April 6, 2018: Nature Communications
Xiaoyuan Bao, Kexin Sun, Xin Tian, Qiongzhou Yin, Meng Jin, Na Yu, Hanfang Jiang, Jun Zhang, Yonghua Hu
BACKGROUND: This study was conducted to describe present and changing trends in surgical modalities and neoadjuvant chemotherapy (NACT) in female breast cancer patients in China from 2006 to 2015. METHODS: Data of 44 299 female breast cancer patients from 15 tertiary hospitals in Beijing were extracted from hospitalization summary reports. Surgeries were categorized into five modalities: breast-conserving surgery (BCS), simple mastectomy (SM), modified radical mastectomy (MRM), radical mastectomy (RM), and extensive radical mastectomy (ERM)...
April 6, 2018: Thoracic Cancer
Atsuhiro Tanikawa, Yoshiaki Shimada, Masayuki Horiguchi
PURPOSE: The clinical course of reduced visual acuity, metamorphopsia, and aniseikonia are dissimilar in patients with an epiretinal membrane (ERM). We measured and compared the best-corrected visual acuity (BCVA), metamorphopsia, and aniseikonia of patients with ERM. METHODS: We measured metamorphopsia and aniseikonia horizontally as well as vertically with the M-CHART (MH and MV) and New Aniseikonia Test (NATH and NATV) in 61 patients with unilateral idiopathic ERM...
April 6, 2018: Japanese Journal of Ophthalmology
Pauline Foveau, Bertrand Leroy, Jean-Paul Berrod, Jean-Baptiste Conart
PURPOSE: To investigate the clinical benefit of internal limiting membrane (ILM) peeling as a surgical adjunct in the repair of primary retinal detachment (RD) complicated by grade B proliferative vitreoretinopathy (PVR). DESIGN: Retrospective, interventional, comparative case series. METHODS: SETTING: Institutional. STUDY POPULATION: 75 consecutive patients who underwent vitrectomy for primary macula off RD complicated by grade B PVR...
April 2, 2018: American Journal of Ophthalmology
Farmanullah Khan, Bashir Ahmad, Jawad Ahmed, Han Sang Yoo, Shumaila Bashir
The hospital environment plays an important role in the spread of microorganisms, including multi drug resistant (MDR) strains. Patients can acquire Methicillin-Resistant Staphylococcus aureus (MRSA) which can reside in the clinical setup that are not cleaned and can spread through air droplets, bed clothing, and healthcare workers. The purpose of this study was to investigate the prevalence of S. aureus in the Khyber Teaching Hospital (KTH). A total of 200 samples were collected from the floor, walls, air and inanimate objects in different wards of the KTH, during May 2012 to September 2012...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Paul-Antoine Moreau, Ermes Toninelli, Peter A Morris, Reuben S Aspden, Thomas Gregory, Gabriel Spalding, Robert W Boyd, Miles J Padgett
Quantum ghost imaging uses photon pairs produced from parametric downconversion to enable an alternative method of image acquisition. Information from either one of the photons does not yield an image, but an image can be obtained by harnessing the correlations between them. Here we present an examination of the resolution limits of such ghost imaging systems. In both conventional imaging and quantum ghost imaging the resolution of the image is limited by the point-spread function of the optics associated with the spatially resolving detector...
March 19, 2018: Optics Express
Bing Zhang, Qilin Yu, Da Huo, Jianrong Li, Chao Liang, Hongyue Li, Xiao Yi, Chenpeng Xiao, Dan Zhang, Mingchun Li
The Arf family of small GTP-binding and hydrolyzing proteins is one of the most important intracellular regulators of membrane dynamics. In this study, we identified the Golgi-localized Arf family G protein Arf1 in Candida albicans and confirmed its conserved function in regulating the secretory pathway. Interestingly, deletion of ARF1 resulted in intracellular oxygen reactive species (ROS) accumulation, and induced formation of the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES). Moreover, N-acetylcysteine (NAC)-mediated ROS scavenging in the arf1Δ/Δ strain attenuated ERMES formation, indicating that intracellular ROS accumulation resulting from ARF1 deletion facilitated ERMES formation...
March 30, 2018: FEBS Journal
Carlo Gilardelli, Francesca Orlando, Ermes Movedi, Roberto Confalonieri
Digital hemispherical photography (DHP) has been widely used to estimate leaf area index (LAI) in forestry. Despite the advancement in the processing of hemispherical images with dedicated tools, several steps are still manual and thus easily affected by user's experience and sensibility. The purpose of this study was to quantify the impact of user's subjectivity on DHP LAI estimates for broad-leaved woody canopies using the software Can-Eye. Following the ISO 5725 protocol, we quantified the repeatability and reproducibility of the method, thus defining its precision for a wide range of broad-leaved canopies markedly differing for their structure...
March 29, 2018: Sensors
Atif A Ahmed, Sultan S Habeebu, Ashley K Sherman, Shui Q Ye, Nicole Wood, Katherine M Chastain, Maria G Tsokos
Rhabdomyosarcoma (RMS) is a common malignancy of soft tissue, subclassified as alveolar (ARMS), pleomorphic (PRMS), spindle cell/sclerosing (SRMS), and embryonal (ERMS) types. The Yes-associated protein (YAP) is a member of the Hippo pathway and a transcriptional regulator that controls cell proliferation. We have studied the immunohistochemical expression of YAP in different RMSs, arranged in tissue microarray (TMA) and whole slide formats. Pertinent clinical data including patient age, gender, tumor location, and clinical stage were collected...
March 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
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