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https://www.readbyqxmd.com/read/28646473/detection-of-foxo1-break-apart-status-by-fluorescence-in-situ-hybridization-in-atypical-alveolar-rhabdomyosarcoma
#1
Libing Fu, Yaqiong Jin, Chao Jia, Jie Zhang, Jun Tai, Hongbin Li, Feng Chen, Jin Shi, Yongli Guo, Xin Ni, Lejian He
The morphologies of alveolar rhabdomyosarcoma (ARMS) are various. Some cases entirely lack an alveolar pattern and instead display a histological pattern that overlaps with embryonal rhabdomyosarcoma (ERMS). The method of pathological diagnosis of ARMS and ERMS has been updated in the 4th edition of the World Health Organization's guidelines for classification of skeletal muscle tumors. Under the new guidelines, there is still no molecular test to distinguish between these two subtypes of rhabdomyosarcoma (RMS)...
June 16, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28637866/endoplasmic-reticulum-mitochondria-junction-is-required-for-iron-homeostasis
#2
Yong Xue, Stefan Schmollinger, Narsis Attar, Oscar Campos, Maria Vogelauer, Michael F Carey, Sabeeha S Merchant, Siavash K Kurdistani
The Endoplasmic Reticulum-Mitochondria Encounter Structure (ERMES) is a protein complex that physically tethers the two organelles to each other and creates the physical basis for communication between them. ERMES functions in lipid and calcium exchange between the ER and mitochondria, protein import into mitochondria and maintenance of mitochondrial morphology and genome. Here we report that ERMES is also required for iron homeostasis. Loss of ERMES components activates an Aft1-dependent iron deficiency response even in iron-replete conditions, leading to accumulation of excess iron inside the cell...
June 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28632410/correlation-between-interleukin-6-and-thrombin-antithrombin-iii-complex-levels-in-retinal-diseases
#3
Rita Ehrlich, Alon Zahavi, Ruth Axer-Siegel, Ivan Budnik, Ayelet Dreznik, Mor Dahbash, Yael Nisgav, Elinor Megiddo, Gili Kenet, Dov Weinberger, Tami Livnat
PURPOSE: This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS: Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20)...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28631180/microvascular-changes-after-vitrectomy-with-internal-limiting-membrane-peeling-an-optical-coherence-tomography-angiography-study
#4
Leonardo Mastropasqua, Enrico Borrelli, Paolo Carpineto, Lisa Toto, Luca Di Antonio, Peter A Mattei, Rodolfo Mastropasqua
PURPOSE: To evaluate superficial capillary plexus (SCP) changes occurring after internal limiting membrane (ILM) peeling for the treatment of idiopathic epiretinal membrane (ERM). METHODS: A total of 15 eyes of 15 patients affected by idiopathic ERM (eight males and seven females; mean age 59.8 ± 9.6 years) were enrolled in the study. Patients were treated with pars plana vitrectomy followed by ERM and ILM peeling. Subjects were evaluated at baseline and at the week-1 and month-1 follow-up visits...
June 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28630628/staphylococcus-saprophyticus-recovered-from-humans-food-and-recreational-waters-in-rio-de-janeiro-brazil
#5
Viviane Santos de Sousa, Ana Paula de Souza da-Silva, Leif Sorenson, Raphael Paiva Paschoal, Renata Fernandes Rabello, Eloiza Helena Campana, Márcia Soares Pinheiro, Lyssa Oliveira Ferreira Dos Santos, Natacha Martins, Ana Carolina Nunes Botelho, Renata Cristina Picão, Sérgio Eduardo Longo Fracalanzza, Lee Woodland Riley, George Sensabaugh, Beatriz Meurer Moreira
Staphylococcus saprophyticus is an important agent of urinary tract infection (UTI) in young women, but information about this pathogen in human microbiota and in common environment is lacking. The aim of this study was to characterize S. saprophyticus isolates from genitoanal microbiota of 621 pregnant women, 10 minas cheese packs, and five beaches in Rio de Janeiro city and compare PFGE profiles of these isolates with five UTI PFGE clusters described in this city. We investigated 65 S. saprophyticus isolates from microbiota, 13 from minas cheese, and 30 from beaches and 32 UTI isolates...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28624994/expression-of-ezrin-and-moesin-in-primary-breast-carcinoma-and-matched-lymph-node-metastases
#6
M Bartova, J Hlavaty, Y Tan, C Singer, K Pohlodek, J Luha, I Walter
Ezrin, radixin, moesin (ERM) are important membrane-cytoskeletal crosslinkers and are suggested to play important role in cancer progression and metastasis. Even though ERM proteins were generally considered to be functionally redundant and the most studied was ezrin, recent studies highlight their distinct roles in metastatic process. Little information is available regarding the role of individual ERM proteins and their phosphorylated forms in human breast cancer. Our study is the first to examine expression of ezrin, moesin and their phosphorylated forms in primary breast tumors and matched lymph node metastases (LNMs) and their correlation with clinicopathological variables...
June 17, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28624454/ameloblast-like-characteristics-of-human-hertwig-s-epithelial-rest-of-malassez-epithelial-rest-of-malassez-cells-via-interaction-with-stem-cells-from-human-exfoliated-deciduous-teeth
#7
Hyun Nam, Gee-Hye Kim, Jae-Won Kim, Jae Cheoun Lee, Kyunghoon Lee, Sun-Ho Lee
Tooth develops through reciprocal interactions between oral epithelium and oral mesenchyme. To regenerate tooth, both components are necessary to mimic epithelial-mesenchymal interactions. In adult teeth, Hertwig's epithelial root sheath/Epithelial rests of Malassez (HERS/ERM) cells are unique epithelial cells which are derived from oral epithelium. In this study, we investigated whether HERS/ERM cells could have ameloblast-like characteristics via interaction with stem cells from human exfoliated deciduous teeth (SHEDs) as an oral mesenchymal component...
June 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28623856/antimicrobial-susceptibility-and-phylogenetic-analysis-of-propionibacterium-acnes-isolated-from-acne-patients-in-japan-between-2013-and-2015
#8
Keisuke Nakase, Nobukazu Hayashi, Yui Akiyama, Sae Aoki, Norihisa Noguchi
The prevalence of antimicrobial-resistant Propionibacterium acnes strains isolated from acne patients has been increasing in Japan. Here, to estimate the current resistance rate, we tested antimicrobial susceptibility among P. acnes from acne patients having visited a specialized dermatology clinic between 2013 and 2015. Rates of resistance to macrolides and clindamycin were 44.3 (31/70) and 38.6% (27/70), respectively. erm(X), which confers high-level clindamycin resistance (minimum inhibitory concentration ≥256 μg/mL), was detected in six isolates, whereas no resistance determinants were identified in eight strains showing high-level resistance to clindamycin...
June 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28623771/liquid-electrode-plasma-optical-emission-spectrometry-combined-with-solid-phase-preconcentration-for-on-site-analysis-of-lead
#9
Suman Barua, Ismail M M Rahman, Iftakharul Alam, Maho Miyaguchi, Hikaru Sawai, Teruya Maki, Hiroshi Hasegawa
A relatively rapid and precise method is presented for the determination of lead in aqueous matrix. The method consists of analyte quantitation using the liquid electrode plasma-optical emission spectrometry (LEP-OES) coupled with selective separation/preconcentration by solid-phase extraction (SPE). The impact of operating variables on the retention of lead in SPEs such as pH, flow rate of the sample solution; type, volume, flow rate of the eluent; and matrix effects were investigated. Selective SPE-separation/preconcentration minimized the interfering effect due to manganese in solution and limitations in lead-detection in low-concentration samples by LEP-OES...
June 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28622861/antimicrobial-susceptibility-and-genotyping-of-staphylococcus-aureus-isolates-collected-between-1986-and-2015-from-ovine-mastitis
#10
Elisa Azara, Maria Giovanna Piras, Antonio Parisi, Sebastiana Tola
In this research, 330 Staphylococcus aureus isolates, collected in Sardinia (Italy) in the period 1986-2015 from clinical ovine mastitis and used for the preparation of inactivated autogenous vaccines, were analyzed. Susceptibility to 12 antimicrobial agents was tested by disk diffusion, according to CLSI recommendations. Resistance genes were detected by PCR assays. The most of isolates (85.2%) were susceptible to all antimicrobials tested, suggesting that did not exist change of resistance over time. Two isolates were multidrug-resistant (MDR), one of them (isolate 1496) showed resistance to seven antibiotics including oxacillin and erythromycin...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28622372/vitrectomy-with-or-without-internal-limiting-membrane-peeling-for-idiopathic-epiretinal-membrane-a-meta-analysis
#11
Wei-Cheng Chang, Chin Lin, Cho-Hao Lee, Tzu-Ling Sung, Tao-Hsin Tung, Jorn-Hon Liu
BACKGROUND: Studies on vitrectomy with and without internal limiting membrane (ILM) peeling for idiopathic epiretinal membrane (ERM) have yielded uncertain results regarding clinical outcomes and recurrence rates. OBJECTIVE: To compare the clinical outcomes of vitrectomy with and without ILM peeling for idiopathic ERM. METHODS: Databases, including PubMed, Embase, Cochrane, Web of Science, Google Scholar, CNKI databases, FDA.gov, and ClinicalTrials...
2017: PloS One
https://www.readbyqxmd.com/read/28614716/the-notch1-snail1-mef2c-pathway-regulates-growth-and-self-renewal-in-embryonal-rhabdomyosarcoma
#12
Myron S Ignatius, Madeline N Hayes, Riadh Lobbardi, Eleanor Y Chen, Karin M McCarthy, Prethish Sreenivas, Zainab Motala, Adam D Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C Beleyea, Deepak Bhere, Matthew S Alexander, Khalid Shah, Charles Keller, Corinne M Linardic, Petur G Nielsen, David Malkin, Javed Khan, David M Langenau
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)-a common pediatric cancer of muscle. Here, we used a zebrafish transgenic model of ERMS to identify a role for intracellular NOTCH1 (ICN1) in increasing TPCs by 23-fold. ICN1 expanded TPCs by enabling the de-differentiation of zebrafish ERMS cells into self-renewing myf5+ TPCs, breaking the rigid differentiation hierarchies reported in normal muscle...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28611754/campylobacter-coli-in-organic-and-conventional-pig-production-in-france-and-sweden-prevalence-and-antimicrobial-resistance
#13
Isabelle Kempf, Annaelle Kerouanton, Stéphanie Bougeard, Bérengère Nagard, Valérie Rose, Gwénaëlle Mourand, Julia Osterberg, Martine Denis, Björn O Bengtsson
The purpose of the study was to evaluate and compare the prevalence and antimicrobial resistance of Campylobacter coli in conventional and organic pigs from France and Sweden. Fecal or colon samples were collected at farms or at slaughterhouses and cultured for Campylobacter. The minimum inhibitory concentrations of ciprofloxacin, nalidixic acid, streptomycin, tetracycline, erythromycin, and gentamicin were determined by microdilution for a total of 263 French strains from 114 pigs from 50 different farms and 82 Swedish strains from 144 pigs from 54 different farms...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28611136/a-rare-case-of-mycobacterium-abscessus-subspecies-abscessus-prosthetic-valve-endocarditis-and-the-clinical-importance-of-inducible-erm-41-gene-testing
#14
Norman Beatty, Craig Brown, Tirdad Zangeneh, Mayar Al Mohajer
A 56-year-old man with a history of injection drug use and two prior episodes of native valve infective endocarditis presented with dyspnoea on exertion. Our preliminary work-up revealed bacteraemia with reported growth of 'Mycobacterium abscessus group' on multiple blood cultures. The patient was later found to have eustachian valve and prosthetic pulmonic valve endocarditis. Initially, he responded to standard antimycobacterial therapy for rapidly growing mycobacteria (RGM) with supporting laboratory susceptibilities...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28609129/efficacy-and-safety-of-guizhi-shaoyao-zhimu-decoction-for-treating-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#15
James W Daily, Ting Zhang, Shihua Cao, Sunmin Park
OBJECTIVES: GuiZhi-ShaoYao-ZhiMu decoction (GSZD), a traditional Chinese herbal medication for the management of rheumatoid arthritis (RA), has a long history of use and modern scientific research support for efficacy, but the studies have not been systematically evaluated. Therefore, this study systematically reviewed the efficacy of GSZD using the available human clinical trials and conducted a meta-analysis. METHODS: The available databases were searched using proper languages of English, Korean, and Chinese...
June 13, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28605961/species-distribution-antibiotic-resistance-and-virulence-traits-in-canine-and-feline-enterococci-in-tunisia
#16
Leila Ben Said, Raoudha Dziri, Nadia Sassi, Carmen Lozano, Karim Ben Slama, Imen Ouzari, Carmen Torres, Naouel Klibi
In order to investigate the possible role of dogs and cats in the carriage and potential dissemination of resistant enterococci, seventy faecal samples from dogs and cats were tested for enterococci. Fifty-eight enterococci were recovered. Isolates were identified as Enterococcus faecium (n = 31) and E. faecalis (n = 14) E. durans (n = 6), E. casseliflavus (n = 2), E. hirae and E. gallinarum (2 isolates each). Enterococcal isolates showed resistance to ciprofloxacin (n = 35), erythromycin (n = 31), tetracycline (n = 25), kanamycin (n = 15), streptomycin (n = 13), pristinamycin (n = 11), gentamicin (n = 10), chloramphenicol (n = 8), and linezolid (n = 6)...
June 2017: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/28604829/phylogenetic-analysis-of-mycobacterium-massiliense-strains-having-recombinant-rpob-gene-laterally-transferred-from-mycobacterium-abscessus
#17
Byoung-Jun Kim, Ga-Na Kim, Bo-Ram Kim, Tae-Sun Shim, Yoon-Hoh Kook, Bum-Joon Kim
Recent multi locus sequence typing (MLST) and genome based studies indicate that lateral gene transfer (LGT) events in the rpoB gene are prevalent between Mycobacterium abscessus complex strains. To check the prevalence of the M. massiliense strains subject to rpoB LGT (Rec-mas), we applied rpoB typing (711 bp) to 106 Korean strains of M. massiliense infection that had already been identified by hsp65 sequence analysis (603 bp). The analysis indicated 6 smooth strains in M. massiliense Type I (10.0%, 6/60) genotypes but no strains in M...
2017: PloS One
https://www.readbyqxmd.com/read/28602912/synthetic-8-hydroxydeoxyguanosine-inhibited-metastasis-of-pancreatic-cancer-through-concerted-inhibitions-of-erm-and-rho-gtpase
#18
Jong-Min Park, Young-Min Han, Migyeong Jeong, Myung Hee Chung, Chang Il Kwon, Kwang Hyun Ko, Ki Baik Hahm
8-hydroxydeoxyguanosine (8-OHdG) is generated consequent to oxidative stress, but its paradoxical anti-oxidative, anti-inflammatory, and anti-mutagenic effects via Rho-GTPase inhibition were noted in various models of inflammation and cancer. Metastasis occurs through cell detachment, epithelial-mesenchymal transition (EMT), and cell migration; during these processes, changes in cell morphology are initiated through Rho-GTPase-dependent actin cytoskeleton polymerization. In this study, we explored the anti-metastatic mechanisms of 8-OHdG in Panc-1 pancreatic cancer cells...
June 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28602805/erm-gene-distribution-among-norwegian-bacteroides-isolates-and-evaluation-of-phenotypic-tests-to-detect-inducible-clindamycin-resistance-in-bacteroides-species
#19
Bjørn Odd Johnsen, Nina Handal, Roger Meisal, Jørgen Vildershøj Bjørnholt, Peter Gaustad, Truls Michael Leegaard
The aims of this study were to describe the distribution of the most common erm genes in a collection of Norwegian Bacteroides isolates and to investigate whether the phenotypic tests for determining inducible clindamycin resistance among Bacteroides species recommended by EUCAST, NordicAST and the manufacturer of E-test(®), are effective. We investigated 175 unique Bacteroides isolates for the presence of erm(B), erm(F) and erm(G) genes, determined their minimum inhibitory concentrations (MICs) to clindamycin and categorised their susceptibility according to EUCAST breakpoints...
June 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28599200/assessment-of-mechanically-ventilated-patients-intoxicated-with-organophosphates-by-a-novel-surface-electromyographic-index
#20
María Bernarda Salazar Sánchez, Alher Mauricio Hernández Valdivieso, Miguel Ángel Mañanas Villanueva
PURPOSE: We present a new electromyographic index, named Engagement of Respiratory Muscle (ERM), for assessing the level of participation of respiratory muscles during spontaneous breathing test in patients poisoned with organophosphorus compound. METHODS: Diaphragm and sternocleidomastoid muscles activity was recorded by surface electromyography during spontaneous breathing test. A population of 23 patients poisoned with organophosphates and mechanically ventilated, and a control group of 28 healthy subjects were analyzed...
May 29, 2017: Journal of Critical Care
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