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https://www.readbyqxmd.com/read/28532801/dissemination-of-erm-b-and-its-associated-multidrug-resistance-genomic-islands-in-campylobacter-from-2013-to-2015
#1
Dejun Liu, Fengru Deng, Yanan Gao, Hong Yao, Zhangqi Shen, Congming Wu, Yang Wang, Jianzhong Shen
A total of 1372 Campylobacter isolates (1107 Campylobacter coli and 265 Campylobacter jejuni) were obtained from 3462 samples collected from slaughterhouses and farms in three representative regions of China (Shandong, Guangdong, and Shanghai) over three successive years (2013-2015). Of these, 84 (84/1372, 6.1%) were erm(B)-positive, and all 84 positive isolates were identified as C. coli (83 chicken isolates and one swine isolate). The prevalence of erm(B) in Campylobacter isolates was compared amongst the different regions and between the three years investigated...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28529264/communities-of-putative-ericoid-mycorrhizal-fungi-isolated-from-alpine-dwarf-shrubs-in-japan-effects-of-host-identity-and-microhabitat
#2
Takahiko Koizumi, Kazuhide Nara
Dwarf shrubs of the family Ericaceae are common in arctic and alpine regions. Many of these plants are associated with ericoid mycorrhizal (ERM) fungi, which allow them to take nutrients and water from the soil under harsh environmental conditions and, thus, affect host plant survival. Despite the importance of ERM fungi to alpine plant communities, limited information is available on the effects of microhabitat and host identity on ERM fungal communities. We investigated the communities of putative ERM fungi isolated from five dwarf shrub species (Arcterica nana, Diapensia lapponica, Empetrum nigrum, Loiseleuria procumbens, and Vaccinium vitis-idaea) that co-occur in an alpine region of Japan, with reference to distinct microhabitats provided by large stone pine (Pinus pumila) shrubs (i...
May 20, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28524883/occurrence-rate-of-retinal-detachment-after-small-gauge-vitrectomy-for-idiopathic-epiretinal-membrane
#3
J Marie-Louise, E Philippakis, A Darugar, R Tadayoni, B Dupas
PurposeTo assess the occurrence rate of retinal detachment (RD) after small gauge vitrectomy for idiopathic epiretinal membrane (ERM).Patients and methodsRetrospective observational case series. The records of consecutive patients operated on for idiopathic ERM using small gauge pars plana vitrectomy between August 2012 and December 2014 with at least a 1-year follow-up were reviewed. All patients were contacted by phone to assess the occurrence of RD during the post-operative follow-up. The main outcome was the occurrence of RD...
May 19, 2017: Eye
https://www.readbyqxmd.com/read/28524158/sequencing-of-dicer1-in-sarcomas-identifies-biallelic-somatic-dicer1-mutations-in-an-adult-onset-embryonal-rhabdomyosarcoma
#4
Leanne de Kock, Barbara Rivera, Timothée Revil, Paul Thorner, Catherine Goudie, Dorothée Bouron-Dal Soglio, Catherine S Choong, John R Priest, Paul J van Diest, Jantima Tanboon, Anja Wagner, Jiannis Ragoussis, Peter Fm Choong, William D Foulkes
BACKGROUND: Sarcomas are rare and heterogeneous cancers. We assessed the contribution of DICER1 mutations to sarcoma development. METHODS: The coding region of DICER1 was sequenced in 67 sarcomas using a custom Fluidigm Access Array. The RNase III domains were Sanger sequenced in six additional sarcomas to identify hotspot DICER1 variants. RESULTS: The median age of sarcoma diagnosis was 45.7 years (range: 3 months to 87.4 years). A recurrent embryonal rhabdomyosarcoma (ERMS) of the broad ligament, first diagnosed at age 23 years, harboured biallelic pathogenic somatic DICER1 variants (1 truncating and 1 RNase IIIb missense)...
May 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28522316/mycobacteriological-characteristics-and-treatment-outcomes-in-extrapulmonary-mycobacterium-abscessus-complex-infection
#5
Suk Hyeon Jeong, Su-Young Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Sung Jae Shin, Won-Jung Koh
OBJECTIVES: Differentiation between Mycobacterium abscessus and M. massiliense and determination of the presence of inducible resistance to macrolide antibiotics are important factors in the management of patients with M. abscessus complex (MABC) infection. Unlike pulmonary MABC infection, little information on extrapulmonary MABC infection is available. METHODS: We performed molecular identification of clinical isolates and assessed the clinical characteristics and treatment outcomes of 20 consecutive patients with extrapulmonary MABC infections...
May 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28521080/histology-fusion-status-and-outcome-in-metastatic-rhabdomyosarcoma-a-report-from-the-children-s-oncology-group
#6
Erin R Rudzinski, James R Anderson, Yueh-Yun Chi, Julie M Gastier-Foster, Caroline Astbury, Frederic G Barr, Stephen X Skapek, Douglas S Hawkins, Brenda J Weigel, Alberto Pappo, William H Meyer, Michael A Arnold, Lisa A Teot, David M Parham
BACKGROUND: Distinguishing alveolar rhabdomyosarcoma (ARMS) from embryonal rhabdomyosarcoma (ERMS) has historically been of prognostic and therapeutic importance. However, classification has been complicated by shifting histologic criteria required for an ARMS diagnosis. Children's Oncology Group (COG) studies after IRS-IV, which included the height of this diagnostic shift, showed both an increased number of ARMS and an increase in the proportion of fusion-negative ARMS. Following diagnostic standardization and histologic re-review of ARMS cases enrolled during this era, analysis of low-risk (D9602) and intermediate-risk (D9803) rhabdomyosarcoma (RMS) studies showed that fusion status rather than histology best predicts prognosis for patients with RMS...
May 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28520641/five-year-follow-up-after-epiretinal-membrane-surgery-a-single-center-experience
#7
Efrat Fleissig, Dinah Zur, Elad Moisseiev, Shay Keren, Oded Ohana, Adiel Barak
PURPOSE: To evaluate the rate of epiretinal membrane (ERM) recurrence in eyes that underwent ERM peeling surgery at least 5 years earlier. METHODS: Retrospective interventional case series study of 37 patients (15 women and 22 men; mean age, 70 ± 7.6 years) operated on for ERM removal with a follow-up of at least 5 years. The patients underwent testing for visual acuity, an ophthalmic examination, and optical coherence tomography imaging, all of which were assessed preoperatively, postoperatively, and at the 5-year follow-up...
May 16, 2017: Retina
https://www.readbyqxmd.com/read/28516842/serotype-distribution-antimicrobial-resistance-and-prevalence-of-pilus-islets-in-pneumococci-following-the-use-of-conjugate-vaccines
#8
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi
PURPOSE: In Japan, the 7-valent pneumococcal vaccine (PCV7) was introduced in 2010 and, in 2013, the PCV7 was replaced with the 13-valent pneumococcal vaccine (PCV13). This study was conducted to investigate serotypes, antimicrobial resistance and prevalence of pilus islets in pneumococcal isolates from inpatients in a Japanese tertiary hospital. METHODOLOGY: From April 2011 to February 2016, 151 isolates [95 (18 children, 77 adults) and 56 (19 children, 37 adults) in the PCV7 and PCV13 periods, respectively] were collected...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28515009/transfer-learning-on-fused-multiparametric-mr-images-for-classifying-histopathological-subtypes-of-rhabdomyosarcoma
#9
Imon Banerjee, Alexis Crawley, Mythili Bhethanabotla, Heike E Daldrup-Link, Daniel L Rubin
This paper presents a deep-learning-based CADx for the differential diagnosis of embryonal (ERMS) and alveolar (ARMS) subtypes of rhabdomysarcoma (RMS) solely by analyzing multiparametric MR images. We formulated an automated pipeline that creates a comprehensive representation of tumor by performing a fusion of diffusion-weighted MR scans (DWI) and gadolinium chelate-enhanced T1-weighted MR scans (MRI). Finally, we adapted transfer learning approach where a pre-trained deep convolutional neural network has been fine-tuned based on the fused images for performing classification of the two RMS subtypes...
May 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28511422/posterior-chamber-scleral-fixation-of-intraocular-lenses-in-post-vitrectomised-aphakic-eyes
#10
Francis Kwasi Obeng, Vipan Kumar Vig, Preetam Singh, Rajbir Singh, Bodhraj Dhawan, Nikhil Sahajpal
INTRODUCTION: The best method of aphakia correction is in the bag implantation of Posterior Chamber Intraocular Lens (PCIOL). When this ideal procedure is not possible due to lack of integrity of posterior capsule or zonules, the other alternatives are broadly categorized into two: extraocular and intraocular. Whereas, the former includes contact lenses and aphakic glasses, the latter ones are further divided into anterior and posterior chamber methods. Anterior Chamber Intraocular Lenses (ACIOL) can be with or without iris claw...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28504889/genetic-characterization-of-vana-enterococcus-faecium-isolates-from-wild-red-legged-partridges-in-portugal
#11
Vanessa Silva, Gilberto Igrejas, Isabel Carvalho, Fernando Peixoto, Lucas Cardoso, José Eduardo Pereira, Rosa Del Campo, Patricia Poeta
Vancomycin-resistant enterococci (VRE) have been detected in wild animals representing a public health concern. The red-legged partridge (Alectoris rufa) is a common game bird and its meat is consumed in several countries, including Portugal. Three hundred five fecal samples of red-legged partridge from the north of Portugal were screened for VRE. Samples were cultured on Slanetz-Bartley agar supplemented with vancomycin (4 mg/L) and six vanA-Enterococcus faecium were recovered. Isolates were tested for antibiotic resistance and virulence genes...
May 15, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28500914/limitations-of-experiments-performed-in-artificially-made-oecd-standard-soils-for-predicting-cadmium-lead-and-zinc-toxicity-towards-organisms-living-in-natural-soils
#12
Mateusz Sydow, Łukasz Chrzanowski, Nina Cedergreen, Mikołaj Owsianiak
Development of comparative toxicity potentials of cationic metals in soils for applications in hazard ranking and toxic impact assessment is currently jeopardized by the availability of experimental effect data. To compensate for this deficiency, data retrieved from experiments carried out in standardized artificial soils, like OECD soils, could potentially be tapped as a source of effect data. It is, however, unknown whether such data are applicable to natural soils where the variability in pore water concentrations of dissolved base cations is large, and where mass transfer limitations of metal uptake can occur...
May 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28493957/ezrin-interacts-with-s100a4-via-both-its-n-and-c-terminal-domains
#13
Beáta Biri-Kovács, Bence Kiss, Henrietta Vadászi, Gergő Gógl, Gyula Pálfy, György Török, László Homolya, Andrea Bodor, László Nyitray
Ezrin belongs to the ERM (ezrin, radixin, moesin) protein family that has a role in cell morphology changes, adhesion and migration as an organizer of the cortical cytoskeleton by linking actin filaments to the apical membrane of epithelial cells. It is highly expressed in a variety of human cancers and promotes metastasis. Members of the Ca2+-binding EF-hand containing S100 proteins have similar pathological properties; they are overexpressed in cancer cells and involved in metastatic processes. In this study, using tryptophan fluorescence and stopped-flow kinetics, we show that S100A4 binds to the N-terminal ERM domain (N-ERMAD) of ezrin with a micromolar affinity...
2017: PloS One
https://www.readbyqxmd.com/read/28482456/antibiotic-resistance-genes-in-municipal-wastewater-treatment-systems-and-receiving-waters-in-arctic-canada
#14
Kara D Neudorf, Yan Nan Huang, Colin M Ragush, Christopher K Yost, Rob C Jamieson, Lisbeth Truelstrup Hansen
Domestic wastewater discharges may adversely impact arctic ecosystems and local indigenous people, who rely on being able to hunt and harvest food from their local environment. Therefore, there is a need to develop efficient wastewater treatment plants (WWTPs), which can be operated in remote communities under extreme climatic conditions. WWTPs have been identified as reservoirs of antibiotic resistance genes (ARGs). The objective of this work was to quantify the presence of nine different ARG markers (int1, sul1, sul2, tet(O), erm(B), mecA, blaCTX-M, blaTEM, and qnr(S)) in two passive systems (waste stabilization ponds [WSPs]) and one mechanical filtration plant operating in two smaller and one large community, respectively, in Nunavut, Canada...
May 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28481155/a-unique-case-series-of-autosomal-recessive-bestrophinopathy-exhibiting-multigenerational-inheritance
#15
Joshua S Hardin, G Bradley Schaefer, Ahmed B Sallam, M Kathryn Williams, Sami Uwaydat
INTRODUCTION: Autosomal recessive bestrophinopathy (ARB) is a retinal disease caused by biallelic mutations of the BEST1 gene. It has a variable phenotype with white flecks in the retina, multifocal yellow subretinal deposits, macular edema, choroidal neovascularization, hyperopia, and electrophysiological abnormalities. We describe a family with ARB and multigenerational inheritance. METHODS: Three generations of a Middle Eastern family (a woman, one son, and two grandchildren) were evaluated by our ocular genetics team...
May 8, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28479252/crystal-structure-of-mdm12-and-combinatorial-reconstitution-of-mdm12-mmm1-ermes-complexes-for-structural-studies
#16
Andrew P AhYoung, Brian Lu, Duilio Cascio, Pascal F Egea
Membrane contact sites between organelles serve as molecular hubs for the exchange of metabolites and signals. In yeast, the Endoplasmic Reticulum - Mitochondrion Encounter Structure (ERMES) tethers these two organelles likely to facilitate the non-vesicular exchange of essential phospholipids. Present in Fungi and Amoebas but not in Metazoans, ERMES is composed of five distinct subunits; among those, Mdm12, Mmm1 and Mdm34 each contain an SMP domain functioning as a lipid transfer module. We previously showed that the SMP domains of Mdm12 and Mmm1 form a hetero-tetramer...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28478681/sensitive-determination-of-cd-in-small-volume-samples-by-miniaturized-liquid-drop-anode-atmospheric-pressure-glow-discharge-optical-emission-spectrometry
#17
Piotr Jamroz, Krzysztof Greda, Anna Dzimitrowicz, Krzysztof Swiderski, Pawel Pohl
A novel liquid drop anode (LDA) direct current atmospheric pressure glow discharge (dc-APGD) system was applied for direct determination of Cd in small-volume samples solutions by optical emission spectrometry (OES). The microdischarge was generated in open-to-air atmosphere between a solid pin type tungsten cathode and liquid drop placed on a graphite disk anode. The arrangement of the graphite disk placed on a PTFE chip platform as well as the solid pin type cathode was simple and robust. The limit of detection (LOD) of Cd for the developed LDA-APGD-OES method was 0...
May 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28473293/moesin-and-merlin-regulate-urokinase-receptor-dependent-endothelial-cell-migration-adhesion-and-angiogenesis
#18
Bernard Degryse, Mishan Britto, Chun Xu Shan, Robert G Wallace, Keith D Rochfort, Philip M Cummins, Gerardene Meade, Ronan P Murphy
The glycosyl-phosphatidyl-inositol (GPI)-anchored urokinase receptor (uPAR) has no intracellular domain, but nevertheless initiates signalling through proximal interactions with other membrane receptors including integrins. The relationships between uPAR and ezrin/radixin/moesin (ERM) proteins, moesin and merlin have never been explored. Moesin and merlin are versatile membrane-actin links and regulators of receptors signalling, respectively. We show that uPAR controls moesin and merlin, which propagate uPAR-initiated signals and modulate integrin functions, thereby regulating uPAR activity...
May 1, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28464483/occurrence-of-antibiotic-resistance-genes-in-the-faecal-dna-of-healthy-omnivores-ovo-lacto-vegetarians-and-vegans
#19
Vesna Milanović, Andrea Osimani, Lucia Aquilanti, Stefano Tavoletti, Cristiana Garofalo, Serena Polverigiani, Alice Litta-Mulondo, Luca Cocolin, Ilario Ferrocino, Raffaella Di Cagno, Silvia Turroni, Camilla Lazzi, Nicoletta Pellegrini, Francesca Clementi
SCOPE: The effects of long-term omnivore, ovo-lacto vegetarian and vegan diets on the occurrence of 12 antibiotic resistance (AR) genes in the human gut was studied. METHODS AND RESULTS: The faeces of 144 healthy volunteers recruited from Turin, Bari, Bologna and Parma were screened for the occurrence of genes conferring resistance to tetracyclines, macrolide-lincosamide-streptogramin B, vancomycin and β-lactams. Overall, erm(B), tet(W) and tet(M) were detected at the highest frequency...
May 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28463846/visual-outcomes-of-pars-plana-vitrectomy-with-epiretinal-membrane-peeling-in-patients-with-asteroid-hyalosis-a-matched-cohort-study
#20
Ali Mouna, Jean-Paul Berrod, Jean-Baptiste Conart
BACKGROUND: The study aimed to evaluate outcomes of epiretinal membrane (ERM) peeling in patients with asteroid hyalosis (AH) and to compare them with those from controls without AH. METHODS: This is a retrospective matched cohort study of 1,104 consecutive patients who underwent surgery for ERM between January 2004 and February 2014. Patients with AH were included in the study group and were matched for preoperative visual acuity, age, gender, date of surgery, and axial length with control patients without AH selected from the same cohort...
May 3, 2017: Ophthalmic Research
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