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Minlu Song, Mengxi Shen, Yanping Zhou, Kairong Zheng, Yuanqi Zhai, Meichun Xiao, Xiaohan Wang, Fenghua Wang, Xiaodong Sun
PURPOSE: To observe features of the posterior vitreous and vitreoretinal interface in highly myopic eyes with retinoschisis using enhanced vitreous imaging optical coherence tomography. METHODS: Comprehensive ophthalmologic examination and enhanced vitreous imaging optical coherence tomography were performed in 77 eyes of 63 patients with highly myopic retinoschisis. Two different modes of spectral domain optical coherence tomography were employed to estimate retinoschisis and the posterior vitreous features in optical coherence tomography images, respectively...
June 13, 2018: Retina
Riccardo Flamini, Marta Menicatti, Mirko De Rosso, Massimo Gardiman, Christine Mayr, Pallecchi Marco, Giovanna Danza, Gianluca Bartolucci
Monoterpene-glycosides are important aroma precursors which, undergo hydrolysis, confer intense floral notes to the wines. Therefore, the knowledge of the nature of the sugar residues and the structure of these molecules is of great interest. In present study, liquid chromatography (LC) separation coupled with different mass spectrometry (MS) experiments for the characterization of these compounds were explored. The LC parameters were tuned to optimize the resolution between the analytes present in grape sample extracts...
June 15, 2018: Journal of Mass Spectrometry: JMS
Syed Aoun Ali, Deeba N Baig
Ezrin, Radixin and Moesin (ERM) are critical membranous component involved in cross-linking of actin filaments. Moesin (Msn) is recognized as a pivotal protein involved in regulation of cell signalling events associated with the maintenance of epithelial integrity, actin organization and polarity. Radixin (Rad) is known to cell-to-cell adherens junction as a barbed end-capping protein whereas ezrin (Ezr) is recognized at cell adhesion, motility, apoptosis and phagocytosis. The current study for the first time reports the transcriptional and RNA secondary structural variations among brain-specific ERM genes...
June 12, 2018: International Journal of Developmental Neuroscience
Hanna J Wagner, Raphael Engesser, Kathrin Ermes, Christian Geraths, Jens Timmer, Wilfried Weber
The translation of engineering designs to materials sciences by means of synthetic biological tools represents a novel concept for the development of information-processing materials systems. Here, we provide data on the mathematical model-guided implementation of a biomaterials-based positive feedback loop for the detection of proteolytic activities. Furthermore, we present data on an extended system design for the detection of the antibiotic novobiocin. This work is related to the research article "Synthetic biology-inspired design of signal-amplifying materials systems" (Wagner et al...
August 2018: Data in Brief
Dhanya Dharmapalan, Francis Yesurajan Inbanathan, Suhas Kharche, Asmita Patil, Shrikrishna Joshi, Vijay Yewale, Jones Lionel Kumar Daniel, Kamini Walia, Balaji Veeraraghavan
Streptococcus pyogenes , belonging to group A streptococcus (GAS), causes over 600 million infections annually being a predominant human pathogen. Lack of genomic data on GAS from India is one limitation to understand its virulence and antimicrobial resistance determinants. The genome of GAS isolates from clinical samples collected at Navi Mumbai, India was sequenced and annotated. Sequencing was performed on Ion Torrent PGM platform. The size of annotated S. pyogenes genomes ranged from ~1.69 to ~1.85 Mb with coverage of 38× to 189×...
June 2018: Data in Brief
Dianpeng Han, Yu Liu, Jingjing Li, Chenghua Liu, Yaping Gao, Jiannan Feng, Huizhe Lu, Guang Yang
Macrolide antibiotics are used for treatment of soft-tissue infection caused by Staphylococcus aureus in humans. However, infections with S. aureus are increasingly difficult to treat owing to the emergence and rapid spread of multiple-drug resistant S. aureus . Resistance to macrolide in S. aureus is mostly due to the modification of 23 S rRNA by methylases encoded by erm genes. Here, we have identified that a 27-nucleotide repeat sequence insertion in the rplV gene induced a specific resistance to macrolide antibiotics...
May 25, 2018: Oncotarget
Søren Kristiansen, Lennart Friis-Hansen, Claus Antonio Juel Jensen, Steen Ingemann Hansen
We verified the lactate dehydrogenase (LDH) reference interval (RI) provided by the Nordic Reference Interval Project (NORIP). The serum LDH concentration was analysed on the Dimension Vista 1500 system with an IFCC method with a bias of +2.1 % and +2.7 % against NFKK Reference Serum X and ERM-AD453/IFCC, respectively, showing verification of transference of the NORIP RI. Selective data mining in clinical laboratory information systems for retrospective serum LDH test results was used to calculate an indirect RI...
June 13, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
Ireneusz Dziuba, Paweł Kurzawa, Michał Dopierała, Ana B Larque, Danuta Januszkiewicz-Lewandowska
The last 25 years have brought significant progress in the treatment of sarcomas in children, especially rhabdomyosarcoma (RMS). Nevertheless, treatment failure in some patients results from considerable biological heterogeneity noted in these tumours. RMS, the most common malignant soft tissue neoplasm in children, includes two main subtypes: embryonal (ERMS) and alveolar (ARMS). Due to greater aggressiveness and worse prognosis of ARMS in comparison to ERMS, discrimination between different rhabdomyosarcoma subtypes is of crucial clinical importance...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Mehdi Goudarzi, Masoumeh Navidinia, Elham Beiranvand, Hossein Goudarzi
The spread of Panton-Valentine leukocidin (PVL)-carrying Staphylococcus aureus strains in both hospital and the community is a significant worldwide problem. The aim of the study was to investigate the clonal dissemination pattern of PVL-producing S. aureus strains isolated from hospitalized patients in Tehran, Iran. In this cross-sectional study, 70 PVL-carrying S. aureus strains were recovered from 240 clinical specimens and characterized by antibiotic susceptibility testing, agr typing, SCCmec typing, spa typing, multilocus sequence typing, and virulence and adhesion gene profiling...
June 12, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Yoshikazu Ichikawa, Yutaka Imamura, Masahiro Ishida
PURPOSE: To examine correlations of inner nuclear layer (INL) thickness with metamorphosia and tangential retinal displacement in epiretinal membrane (ERM). DESIGN: Retrospective, consecutive, interventional case series. METHODS: SETTING: Institutional study PATIENT POPULATION: Fifty eyes of 50 patients undergoing epiretinal membrane surgery OBSERVATION PROCEDURES: M-CHARTS were used to measure metamorphopsia. Inner nuclear layer (INL) thickness and outer retinal layer (ORL) thickness in the macula and distances between the intersections of 2 sets of retinal vessels situated vertically or horizontally were measured in Spectralis OCT and infrared images...
June 8, 2018: American Journal of Ophthalmology
Jinpeng Xu, Haiyan Jia, Guanghui Cui, Huixian Tong, Jianchao Wei, Donghua Shao, Ke Liu, Yafeng Qiu, Beibei Li, Zhiyong Ma
SXT/R391 integrative conjugative elements (ICEs) are capable of self-transfer by conjugation and highly prevalent in various aquatic bacteria and Proteus species. In the present study, a novel SXT/R391 ICE, named ICEAplChn1, was identified in the multidrug resistant (MDR) Actinobacillus pleuropneumoniae strain app6. ICEAplChn1 was composed of the typical SXT/R391 backbone and insertion DNA at eight hotspots, including HS1, HS2, HS3, HS4, HS5, VRII, VRIII and a new variation region VRVI. Many of the insertion contents were not present in other reported SXT/R391 family members, including ICEApl2, a recently identified SXT/R391 ICE from a clinical isolate of A...
July 2018: Veterinary Microbiology
Li Jia, Yinhu Wang, Yanxia Wang, Yinhui Qin, Chaoyu Hu, Juzheng Sheng, Shutao Ma
A series of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity. The results showed that the majority of the target compounds displayed potent activity against erythromycin-susceptible S. pyogenes, erythromycin-resistant S. pneumoniae A22072 expressing the mef gene and S. pneumoniae AB11 expressing the mef and erm genes. Besides, most of the target compounds exhibited moderate activity against erythromycin-susceptible S...
June 2, 2018: Bioorganic & Medicinal Chemistry Letters
Daisaku Kimura, Takatoshi Kobayashi, Eri Maruyama, Shou Oosuka, Ryohsuke Kohmoto, Masanori Fukumoto, Takaki Sato, Teruyo Kida, Tsunehiko Ikeda
RATIONALE: To report a case of familial exudative vitreoretinopathy (FEVR) complicated with full-thickness macular hole (FTMH). PATIENT CONCERNS: A 39-year-old male presented after becoming aware of metamorphopsia in his left eye. DIAGNOSES: Fundus examination showed a retinal avascular area, retinal vascular abnormality, and yellow exudation at the peripheral retina in both eyes. Optical coherence tomography findings revealed impending MH (IMH) due to posterior vitreous detachment (PVD) in his left eye...
June 2018: Medicine (Baltimore)
Ayelén González Montoro, Kathrin Auffarth, Carina Hönscher, Maria Bohnert, Thomas Becker, Bettina Warscheid, Fulvio Reggiori, Martin van der Laan, Florian Fröhlich, Christian Ungermann
The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLAMP). Formation of vCLAMPs involves the vacuolar Rab GTPase Ypt7 and the Ypt7-interacting Vps39 subunit of the HOPS tethering complex. Here, we uncover the general preprotein translocase of the outer membrane (TOM) subunit Tom40 as the direct binding partner of Vps39 on mitochondria...
June 4, 2018: Developmental Cell
Shao-Yang Tsai, Satish Jaiswal, Chi-Fu Chang, Wei-Kuang Liang, Neil G Muggleton, Chi-Hung Juan
Prior studies have reported that meditation may improve cognitive functions and those related to attention in particular. Here, the dynamic process of attentional control, which allows subjects to focus attention on their current interests, was investigated. Concentrative meditation aims to cultivate the abilities of continuous focus and redirecting attention from distractions to the object of focus during meditation. However, it remains unclear how meditation may influence attentional reorientation, which involves interaction between both top-down and bottom-up processes...
2018: Frontiers in Integrative Neuroscience
Silvia Perotto, Stefania Daghino, Elena Martino
Contents I. II. III. IV. V. VI. VII. References SUMMARY: The genome of an organism bears the signature of its lifestyle, and organisms with similar life strategies are expected to share common genomic traits. Indeed, ectomycorrhizal and arbuscular mycorrhizal fungi share some genomic traits, such as the expansion of gene families encoding taxon-specific small secreted proteins, which are candidate effectors in the symbiosis, and a very small repertoire of plant cell wall-degrading enzymes. A large gene family coding for candidate effectors was also revealed in ascomycetous ericoid mycorrhizal (ERM) fungi, but these fungal genomes are characterised by a very high number of genes encoding degradative enzymes, mainly acting on plant cell wall components...
May 31, 2018: New Phytologist
Joanna Stafiej, Karolina Kaźmierczak, Katarzyna Linkowska, Paweł Żuchowski, Tomasz Grzybowski, Grażyna Malukiewicz
Purpose: To evaluate the expression profiles of the VEGF α and TGF β in the ERMs and ILMs in retinal disorders. Methods: In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. The samples of ERMs and ILMs collected during PPV were immediately put in TRIzol® Reagent (Life Technologies, USA) and stored at -70°C until RNA extraction. Gene expression analysis was done with TaqMan® Gene Expression Assays (Applied Biosystems, USA) following the manufacturer's instructions...
2018: Journal of Ophthalmology
Yo-Chen Chang, Chia-Ling Lee, Kuo-Jen Chen, Li-Yi Chiu, Tzu-En Kao, Pei-Kang Liu, Kwou-Yeung Wu, Wen-Chuan Wu
Purpose: To investigate the morphological and functional outcomes of idiopathic epiretinal membrane (ERM) surgery between three different surgical techniques: ERM peeling only, whole-piece ILM peeling, and maculorrhexis ILM peeling. Patients and Methods: This is a retrospective, consecutive, and comparative study enrolling 60 patients from Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Surgery performed between July 2011 and June 2012 was done with ERM peeling only (group I)...
2018: Journal of Ophthalmology
Carmine Pinto, Nicola Normanno, Armando Orlandi, Francesca Fenizia, Angela Damato, Evaristo Maiello, Emiliano Tamburini, Francesco Di Costanzo, Giuseppe Tonini, Domenico Bilancia, Domenico Corsi, Salvatore Pisconti, Francesco Ferrau, Stefania Gori, Bruno Daniele, Alberto Zaniboni, Héctor Soto Parra, Giovanni Luca Frassinetti, Rosario Vincenzo Iaffaioli, Maria Giulia Zampino, Lazzaro Repetto, Maria Alessandra Calegari, Carlo Barone
The optimal duration and intensity of first-line therapy in metastatic colorectal cancer patients once they have achieved an objective response is controversial. In a molecularly selected RAS and BRAF wild-type (wt) population, this concern is amplified. Once disease control has been achieved with a combination therapy including an anti-EGFR antibody, further exposure both to cytotoxic drugs and targeted therapy might result only in increased toxicity. In unresectable metastatic RAS and BRAF wt colorectal cancer patients, a deintensified therapy could represent a valuable option that might preserve quality of life...
May 30, 2018: Future Oncology
Allen E-J Yeoh, Zhenhua Li, Difeng Dong, Yi Lu, Nan Jiang, Jan Trka, Ah Moy Tan, Hai Peng Lin, Thuan Chong Quah, Hany Ariffin, Limsoon Wong
Accurate risk assignment in childhood acute lymphoblastic leukaemia is essential to avoid under- or over-treatment. We hypothesized that time-series gene expression profiles (GEPs) of bone marrow samples during remission-induction therapy can measure the response and be used for relapse prediction. We computed the time-series changes from diagnosis to Day 8 of remission-induction, termed Effective Response Metric (ERM-D8) and tested its ability to predict relapse against contemporary risk assignment methods, including National Cancer Institutes (NCI) criteria, genetics and minimal residual disease (MRD)...
June 2018: British Journal of Haematology
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