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appendix carcinoid

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https://www.readbyqxmd.com/read/27830037/goblet-cell-carcinoids-of-the-appendix-tumor-biology-mutations-and-management-strategies
#1
REVIEW
Santosh Shenoy
Malignant neoplasms of the appendix are rare and represent less than 1% of gastrointestinal cancers. Goblet cell carcinoids (GCC) tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. This review focuses on the current diagnostic procedures, pathogenesis, possible signaling mechanisms and treatment options for GCC. Perspectives for future research are discussed. The tumor likely arises from pluripotent intestinal epithelial crypt base stem cells...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27785320/mixed-adenocarcinoid-tumor-presenting-as-acute-appendicitis
#2
Kalyani Regeti, Waqas Jehangir, Shoaib Zafar, Shuvendu Sen, Ibrahim Sidhom, Abdalla Yousif
Mixed adenocarcinoid tumors are not uncommon neoplasms of appendix. The clinical presentation of these tumors is often similar to that of acute appendicitis or may present as asymptomatic. These tumors are found incidentally during histopathological examination of the resected appendix following appendectomy or other abdominal procedures. Mixed adenocarcinoids usually behave as adenocarcinomas with rapid metastasis, so prognosis depends upon how aggressive the tumor behaves. The present study reports a case of a 53-year-old male who presented with abdominal pain and fever for 1 day and underwent successful appendectomy and recovered later...
February 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27773125/synchronous-sessile-serrated-adenoma-and-goblet-cell-carcinoid-in-the-appendix-a-case-report-and-literature-review
#3
Zheqin R Lu, Phillip Jayasurya
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27716878/data-quality-in-rare-cancers-registration-the-report-of-the-rarecare-data-quality-study
#4
Annalisa Trama, Rafael Marcos-Gragera, Maria Josè Sánchez Pérez, Jan Maarten van der Zwan, Eva Ardanaz, Christine Bouchardy, Juan Manuel Melchor, Carmen Martinez, Riccardo Capocaccia, Massimo Vicentini, Sabine Siesling, Gemma Gatta
PURPOSE: Rare cancers represent 22% of all tumors in Europe; however, the quality of the data of rare cancers may not be as good as the quality of data for common cancer. The project surveillance of rare cancers in Europe (RARECARE) had, among others, the objective of assessing rare cancer data quality in population-based cancer registries (CRs). Eight rare cancers were considered: mesothelioma, liver angiosarcoma, sarcomas, tumors of oral cavity, CNS tumors, germ cell tumors, leukemia, and malignant digestive endocrine tumors...
October 3, 2016: Tumori
https://www.readbyqxmd.com/read/27595862/elevated-risk-of-subsequent-malignancies-in-patients-with-appendiceal-cancer-a-population-based-analysis
#5
Adil Ayub, Om Parkash, Norberto Santana-Rodríguez, Wissam Raad, Faiz Y Bhora
BACKGROUND: Appendiceal cancer is extremely rare with excellent survival after curative resection. There is a concern for the development of additional cancers in survivors of appendiceal cancer. However, existing data is limited to small anecdotal reports on appendiceal carcinoid only. We aim to investigate the risk of subsequent malignancies in patients with appendiceal carcinoma and correlate the risk according to patient and clinical characteristics. METHODS: We identified 3788 patients with appendiceal cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database between 1992 and 2011...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27379210/appendiceal-mixed-adeno-neuroendocrine-carcinoma-a-population-based-study-of-the-surveillance-epidemiology-and-end-results-registry
#6
Shayna Brathwaite, Martha M Yearsley, Tanios Bekaii-Saab, Lai Wei, Carl R Schmidt, Mary E Dillhoff, Wendy L Frankel, John L Hays, Christina Wu, Sherif Abdel-Misih
INTRODUCTION: Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently defined by the World Health Organization (WHO) in 2010. Prior to the definition by the WHO, tumors with both adenocarcinoma and neuroendocrine components were given multiple pathological designations making it difficult to characterize the disease. The aim of our study is to better characterize MANEC to better understand its natural history to influence patient care and positively impact outcomes...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27371613/differing-expression-profiles-of-notch-enterocyte-and-wnt-secretory-lineage-signallings-are-associated-with-morphological-diversity-of-appendiceal-tumours
#7
Xianyong Gui, Ziran Meng, Yarrow J McConnell, Shuhong Liu, Vincent G Falck, Lloyd A Mack, Walley J Temple
BACKGROUND: Tumours of appendix, including classic carcinoid tumour (CCT), goblet cell carcinoid (GCC), low-grade appendiceal mucinous neoplasm, high-grade appendiceal mucinous neoplasm/mucinous carcinoma (MCA) and non-mucinous adenocarcinoma (NMA), show different and sometimes mixed morphological features. It was hypothesised that these tumours originate from common tumour stem cell(s) with potential of various cell lineage differentiation. In normal intestinal epithelium, absorptive lineage (enterocytes) differentiation is driven by Notch-Hes1 pathway, while secretory lineage is driven by Wnt-Math1 pathway and further separated by different downstream signallings into three sublineages (Gfi1-Klf4/Elf3 for goblet cells, Gfi1-Sox9 for Paneth cells and Ngn3-Pdx1/Beta2/Pax4 for enteroendocrine cells)...
July 1, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27338636/adenocarcinoma-ex-goblet-cell-carcinoid-appendiceal-type-crypt-cell-adenocarcinoma-is-a-morphologically-distinct-entity-with-highly-aggressive-behavior-and-frequent-association-with-peritoneal-intra-abdominal-dissemination-an-analysis-of-77-cases
#8
Michelle D Reid, Olca Basturk, Walid L Shaib, Yue Xue, Serdar Balci, Hye-Jeong Choi, Gizem Akkas, Bahar Memis, Brian S Robinson, Bassel F El-Rayes, Charles A Staley, Christopher A Staley, Joshua H Winer, Maria C Russell, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
High-grade versions of appendiceal goblet cell carcinoids ('adenocarcinoma ex-goblet cell carcinoids') are poorly characterized. We herein document 77 examples. Tumors occurred predominantly in females (74%), mean age 55 years (29-84), most with disseminated abdominal (77% peritoneal, 58% gynecologic tract involvement) and stage IV (65%) disease. Many presented to gynecologic oncologists, and nine had a working diagnosis of ovarian carcinoma. Metastases to liver (n=3) and lung (n=1) were uncommon and none arose in adenomatous lesions...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27311320/acute-appendicitis-with-a-neuroendocrine-tumor-g1-carcinoid-pitfalls-of-conservative-treatment
#9
Hiroyuki A Watanabe, Taketoshi Fujimoto, Yo Kato, Mayumi Sasaki, Toshikazu Ikusue
A man in his early thirties presented to our clinic with right lower abdominal pain. Computed tomography (CT) and ultrasonography (US) revealed a swollen appendix and an appendicolith. Abscess formation was not observed but ongoing appendiceal rupture was not ruled out. Three months after successful conservative therapy, the lumen of the apical portion was kept dilated and laparoscopic interval appendectomy was performed. No tumorous findings were observed macroscopically. However, histology revealed many tiny nests infiltrating the submucosa, muscular layer, and subserosa at the root of the appendix...
August 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27306228/neuroendocrine-tumor-of-the-appendix-in-children
#10
Hao Wu, Murali Chintagumpala, John Hicks, Jed G Nuchtern, M Fatih Okcu, Rajkumar Venkatramani
Neuroendocrine tumor (NET) of the appendix is the most common gastrointestinal epithelial tumor in children. The utility of serum markers or the indication for hemicolectomy has not been established in children. In 45 children diagnosed with appendiceal NET, 89% NETs were incidentally found following appendectomy performed for suspected acute appendicitis. The median age was 12 years, and 56% patients were female. Postoperative somatostatin scan (n=5), serum chromogranin A (n=4), and urine 5-HIAA (n=9) were all within normal limits...
June 14, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27303130/carcinoid-tumour-of-caecum-an-unusual-palpable-mass-in-the-right-iliac-fossa
#11
Mohit M Agrawal, Nandkishor S Sude
Carcinoid tumour represents 0.8-1.5 % of malignant digestive tumours. Gastrointestinal (GI) carcinoids account for 95 % of all the carcinoids, and caecal carcinoids account for 5 % of all the carcinoids. These tumours are frequent in women (2-4:1) as reported by Spallitta and Termine (Minerva Chir 55:77-87, 2002). In order of frequency, they may occur in the appendix (35 %), ileum (28 %), rectum (13 %) and bronchi. Incidence is less than 1 % in the pancreas, gall bladder, liver, larynx, testes and ovaries...
April 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27296408/-carcinoid-of-the-appendix-goblet-cells-metastasize-to-the-orbit-a-clinical-case-report-and-review-of-the-literature
#12
REVIEW
V M Matějka, P Mukenšnabl, R Tupý, O Fiala, J Fínek
Goblet cell carcinoid (GCC) of the appendix is extremely rare, representing approximately 5% of all primary appendiceal neoplasms. Histologically there are three groups of GCC: group A (typical GCC), adenocarcinoma ex GCC signet ring cell type (group B), and adenocarcinoma ex GCC poorly differentiated carcinoma type (group C), which is the most aggressive. GCC metastasizes in 15-60% of cases, mainly to the ovaries, pelvis, abdominal cavity, ribs, vertebrae, and lymph nodes. Hematogenous metastasis to the liver or other parenchymal organs can occur, but this is very rare...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27251847/perforated-meckel-s-diverticulum-containing-a-carcinoid-tumor-successfully-treated-by-the-laparoscopic-approach-case-report
#13
Yuhamy Curbelo-Peña, Juan Dardano-Berriel, Xavier Guedes-De la Puente, Maria Saladich-Cubero, Tomas Stickar, Enric De Caralt-Mestres
Mekel's diverticulum is a gastrointestinal malformation. Occurs in one of every 40 patients. It is usually asymptomatic whereas complications can be developed in 2% to 4%. The report is based on a 41-year old male, who attended to emergency, complaining of right lower quadrant abdominal pain. Blood tests showed high level of inflammatory markers. With acute appendicitis as presumptive diagnosis, laparoscopy was performed. The intraoperative findings were: a perforated Mekel's diverticulum with normal cecal appendix...
October 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27065718/pathology-of-mucinous-appendiceal-tumors-and-pseudomyxoma-peritonei
#14
REVIEW
Veena Ramaswamy
Neoplasms of the appendix are rare, but because of their unusual presentation and unpredictable biologic behavior, it is important to diagnose them correctly. Mucinous tumors account for 58 % of malignant tumors of appendix in SEER database and the remaining are carcinoids. The mucinous appendiceal tumors have a potential to spread to the peritoneum and viscera in the form of gelatinous material with or without neoplastic cells resulting in Pseudomyxoma peritonei. (PMP) PMP is a clinical entity that has a unique biological behavior and can arise from seemingly benign tumors to frankly malignant ones...
June 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27065691/an-unusual-case-of-appendiceal-carcinoid-tumor-in-a-child-case-report
#15
S Sushma, C S B R Prasad, K Mohan Kumar
Carcinoid tumors of the appendix are rare in children. They clinically present with features of acute appendicitis and are often diagnosed incidentally on the resected specimens. Local disease carries an excellent prognosis and simple appendicectomy suffices, whereas advanced cases need a right hemicolectomy. Clinicians must be aware of this under reported and rare tumor in chidren. We report a case of appendiceal carcinoid tumor in a 10 year old male child who presented with clinical features of acute appendicitis which was diagnosed on histopathological examination...
March 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26965701/mixed-adeno-neuroendocrine-carcinoma-an-aggressive-clinical-entity
#16
Shayna Brathwaite, Jonathan Rock, Martha M Yearsley, Tanios Bekaii-Saab, Lai Wei, Wendy L Frankel, John Hays, Christina Wu, Sherif Abdel-Misih
BACKGROUND: Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathologic diagnosis recently defined by the World Health Organization in 2010. Due to poor understanding of MANEC as a clinical entity, there is significant variation in the management of these patients. The purpose of our study was to characterize MANEC to develop evidence-based treatment strategies. METHODS: The Ohio State University patient database was queried for the diagnosis of MANEC and 46 patients were identified...
July 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26833956/two-rare-cases-of-appendiceal-collision-tumours-involving-an-appendiceal-mucinous-neoplasm-and-carcinoid
#17
Hwee Leong Tan, Grace Hwei Ching Tan, Melissa Teo
We report two rare cases of appendiceal collision tumours, each involving an appendiceal mucinous neoplasm with a concomitant appendiceal carcinoid. The first case presented with acute appendicitis while the second presented with an incidental radiological finding of an enlarged appendix as part of evaluation for raised serum carcinoembryonic antigen. Diagnosis in both cases was made postoperatively on histological assessment following appendicectomy. Clinical and histological features of both tumour types in each case did not necessitate further surgical resection or adjuvant treatment...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26805317/-a-case-of-goblet-cell-carcinoid-diagnosed-after-appendectomy
#18
Kei Kimura, Yoshinori Kagawa, Takeshi Kato, Yoshiteru Katsura, Yoshiaki Ohmura, Atsushi Takeno, Hideki Sakisaka, Hirokazu Taniguchi, Yutaka Takeda, Shigeyuki Tamura
A man in his 60's was admitted to our hospital because of right lower abdominal pain. We diagnosed acute appendicitis with an abscess, and he was treated with laparoscopic-assisted appendectomy. The histopathological diagnosis was a goblet cell carcinoid (GCC) of the appendix. Because of the possibility of lymph node metastasis, the patient underwent laparoscopic- assisted ileo-cecum resection with lymph node dissection (D2). Metastasis was detected in one of the dissected lymph nodes. This patient has been followed-up for a year after surgery and no recurrences have been detected...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26663900/surgical-management-of-neuroendocrine-tumors-of-the-appendix-in-children-and-adolescents-a-retrospective-french-multicenter-study-of-114-cases
#19
MULTICENTER STUDY
Guénolée de Lambert, Hubert Lardy, Hélène Martelli, Daniel Orbach, Frédéric Gauthier, Florent Guérin
BACKGROUND: Right hemicolectomy (RHC) in patients with neuroendocrine tumors (NET) of the appendix has been advocated for tumors more than 2 cm, or with mesoappendix/vessel invasion, or with raised mitotic activity. No study demonstrated prolonged survival with RHC over appendectomy alone. The aim of this study was to contribute to define guidelines for secondary surgery in children or adolescents with NET of the appendix. PROCEDURE: We contacted all French pediatric surgeons and oncologists by mail, and reviewed the records of patients under 18 with NET of the appendix from 1988 until 2012...
April 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26612593/appendiceal-mixed-adenoneuroendocrine-carcinomas-a-rare-entity-that-can-present-as-a-krukenberg-tumor-case-report-and-review-of-the-literature
#20
Margarita Romeo, Ariadna Quer, Antoni Tarrats, Carlos Molina, Joaquim Radua, José-Luís Manzano
BACKGROUND: Mixed adenoneuroendocrine carcinoma is a rare tumor recently recognized as a new category in the last World Health Organization (WHO) classification of appendiceal tumors (2010). This term has been proposed to designate carcinomas of the appendix that arise by progression from a pre-existing goblet cell carcinoid. Mixed adenoneuroendocrine carcinomas are more aggressive tumors than typical goblet cell carcinoids and usually present with peritoneal spreading and ovarian masses...
2015: World Journal of Surgical Oncology
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