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appendix carcinoid

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https://www.readbyqxmd.com/read/28326748/carcionoid-of-the-appendix-in-pregnant-woman-case-report-and-literature-review
#1
(no author information available yet)
Neuroendocrine neoplasms are detected very rarely in pregnant women. The following is a case report of carcinoid tumor of the appendix diagnosed in 28 year-old woman at 25th week of gestation. The woman delivered spontaneously a healthy baby at the 38th week of gestation. She did not require adjuvant therapy with somatostatin analogues. The patient remained in remission. There are not established standards of care due to the very rare incidence of carcinoid tumors in pregnancy. A review of the literature related to management and prognosis in such cases was done...
January 22, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28302663/amyand-s-hernia-containing-an-appendiceal-goblet-cell-carcinoid-tumour
#2
Zarif Yahya, Chien-I Wang, Boon Hong
Amyand's hernia is a rare occurrence where the appendix is trapped within an inguinal hernia. Appendicitis within the hernia is even rarer. However, the presence of an appendiceal neoplasm in an inguinal hernia is almost unheard of with only two cases reported in the literature. We present an extremely rare case of an inflamed appendix within an Amyand's hernia, which was found to be a goblet cell type carcinoid tumour requiring further oncological resection and treatment.
March 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28302361/unexpected-findings-after-surgery-for-suspected-appendicitis-rarely-change-treatment-in-pediatric-patients-results-from-a-cohort-study
#3
Ramon R Gorter, Paul van Amstel, Johanna H van der Lee, Patick van der Voorn, Roel Bakx, Hugo A Heij
BACKGROUND: To determine if non-operative treatment is safe in children with acute appendicitis, we evaluated the incidence of unexpected findings after an appendectomy in children, and the influence they have on subsequent treatment. METHODS: A historical cohort study (January 2004-December 2014) was performed including children, aged 0-17 years, who underwent an appendectomy for the suspicion of acute appendicitis. Patients were divided based upon histopathological examination...
March 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28280620/potential-actionable-targets-in-appendiceal-cancer-detected-by-immunohistochemistry-fluorescent-in-situ-hybridization-and-mutational-analysis
#4
Erkut Borazanci, Sherri Z Millis, Jeffery Kimbrough, Nancy Doll, Daniel Von Hoff, Ramesh K Ramanathan
BACKGROUND: Appendiceal cancers are rare and consist of carcinoid, mucocele, pseudomyxoma peritonei (PMP), goblet cell carcinoma, lymphoma, and adenocarcinoma histologies. Current treatment involves surgical resection or debulking, but no standard exists for adjuvant chemotherapy or treatment for metastatic disease. METHODS: Samples were identified from approximately 60,000 global tumors analyzed at a referral molecular profiling CLIA-certified laboratory. A total of 588 samples with appendix primary tumor sites were identified (male/female ratio of 2:3; mean age =55)...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28211279/diverticulitis-of-the-appendix-as-debut-of-appendicular-cystadenoma-and-carcinoid-tumor
#5
Laura Fernández Gómez-Cruzado, Mikel Prieto Calvo, Christian Pérez González, Jasone Larrea Oleaga
Appendiceal diverticulosis is a rare condition with a frequency of 0.004% to 2.1%, and is sometimes an occasional finding during anatomopathologic study of the surgical specimen. It may be presented acutely as a right lower quadrant pain, similar to acute appendicitis for which differential diagnosis must be carried out, and it is associated with appendicular tumors. We report a case of diverticulitis of the appendix as debut of appendicular cystadenoma and carcinoid tumor with representative iconography, being unusual the association of both diseases and even more its preoperative diagnosis...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28211016/adenocarcinoma-ex-goblet-cell-carcinoid-of-the-appendix-a-case-report-and-overview-of-the-disease
#6
Uroosa Ibrahim, Gautam Valecha, Gwenalyn Garcia, Amina Saqib, Monika Wrzolek, Meekoo Dhar
No abstract text is available yet for this article.
February 17, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28133078/-a-case-of-curatively-resected-goblet-cell-carcinoid-of-the-appendix-diagnosed-via-intraoperative-frozen-sectional-examination
#7
Tomoya Ikeda, Junichiro Yamauchi, Kento Miyazaki, Sho Yasuta, Shota Fujita, Mamoru Satoh, Keiichi Shirasaki, Shin Kobayashi, Takashi Ajiki, Katsuo Tsuchihara, Noriko Kondo, Shuichi Ishiyama
A 52-year-old patient presented with epigastric pain.An enhanced CT scan showed a strongly enhanced appendix with abscess formation.Appendectomy was performed under the diagnosis of acute appendicitis with perityphlitic abscess.The stump of the appendix was white and hard, suggesting malignant transformation.Intraoperative frozen sectional examination indicated goblet cell carcinoid(GCC)of the appendix.Thereafter, we performed ileocecal resection with lymphadenectomy (D3).The final pathological diagnosis was GCC, pSS, pN1, Stage III a by the Japanese classification of colorectal carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133074/-a-case-of-goblet-cell-carcinoid-of-the-appendix-invading-directly-into-the-sigmoid-colon
#8
Satoru Matsumoto, Masahiro Takahashi, Shusaku Takahashi, Hideki Yamagami, Hiroyuki Ishizu
A 73-year-old man underwent a screening colonoscopy, and a depressed lesion in the sigmoid colon was detected. Biopsy revealed a Group V lesion, and he was diagnosed with sigmoid colon cancer. During surgery, there was dense adhesion of the appendix to the sigmoid colon, and sigmoidectomy combined with appendectomy was performed. However, pathological examination revealed goblet cell carcinoid of the appendix with direct invasion into the sigmoid colon. To the best of our knowledge, no similar cases have been reported in Japan...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27989046/valve-replacement-in-patients-with-carcinoid-heart-disease-choosing-the-right-valve-at-the-right-time
#9
Amit Korach, Simona Grozinsky-Glasberg, Joseph Atlan, Abeer Dabah, Karine Atlan, Ehud Rudis, Amir Elami, David J Gross, Michael J Reardon, Oz M Shapira
BACKGROUND: The prosthetic valve of choice in patients with carcinoid valve disease (CVD) remains controversial due to the limited life expectancy of patients with advanced-stage neuroendocrine tumors (NETs) on the one hand, and concerns regarding structural valve deterioration (SVD) on the other hand. METHODS: The records of 17 patients (11 females, seven males; mean age 65 ± 11 years; undergoing 18 operations) with primarily right heart failure due to CVD were reviewed...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27830037/goblet-cell-carcinoids-of-the-appendix-tumor-biology-mutations-and-management-strategies
#10
REVIEW
Santosh Shenoy
Malignant neoplasms of the appendix are rare and represent less than 1% of gastrointestinal cancers. Goblet cell carcinoids (GCC) tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. This review focuses on the current diagnostic procedures, pathogenesis, possible signaling mechanisms and treatment options for GCC. Perspectives for future research are discussed. The tumor likely arises from pluripotent intestinal epithelial crypt base stem cells...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27785320/mixed-adenocarcinoid-tumor-presenting-as-acute-appendicitis
#11
Kalyani Regeti, Waqas Jehangir, Shoaib Zafar, Shuvendu Sen, Ibrahim Sidhom, Abdalla Yousif
Mixed adenocarcinoid tumors are not uncommon neoplasms of appendix. The clinical presentation of these tumors is often similar to that of acute appendicitis or may present as asymptomatic. These tumors are found incidentally during histopathological examination of the resected appendix following appendectomy or other abdominal procedures. Mixed adenocarcinoids usually behave as adenocarcinomas with rapid metastasis, so prognosis depends upon how aggressive the tumor behaves. The present study reports a case of a 53-year-old male who presented with abdominal pain and fever for 1 day and underwent successful appendectomy and recovered later...
February 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27773125/synchronous-sessile-serrated-adenoma-and-goblet-cell-carcinoid-in-the-appendix-a-case-report-and-literature-review
#12
Zheqin R Lu, Phillip Jayasurya
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27716878/data-quality-in-rare-cancers-registration-the-report-of-the-rarecare-data-quality-study
#13
Annalisa Trama, Rafael Marcos-Gragera, Maria Josè Sánchez Pérez, Jan Maarten van der Zwan, Eva Ardanaz, Christine Bouchardy, Juan Manuel Melchor, Carmen Martinez, Riccardo Capocaccia, Massimo Vicentini, Sabine Siesling, Gemma Gatta
PURPOSE: Rare cancers represent 22% of all tumors in Europe; however, the quality of the data of rare cancers may not be as good as the quality of data for common cancer. The project surveillance of rare cancers in Europe (RARECARE) had, among others, the objective of assessing rare cancer data quality in population-based cancer registries (CRs). Eight rare cancers were considered: mesothelioma, liver angiosarcoma, sarcomas, tumors of oral cavity, CNS tumors, germ cell tumors, leukemia, and malignant digestive endocrine tumors...
January 21, 2017: Tumori
https://www.readbyqxmd.com/read/27595862/elevated-risk-of-subsequent-malignancies-in-patients-with-appendiceal-cancer-a-population-based-analysis
#14
Adil Ayub, Om Parkash, Norberto Santana-Rodríguez, Wissam Raad, Faiz Y Bhora
BACKGROUND: Appendiceal cancer is extremely rare with excellent survival after curative resection. There is a concern for the development of additional cancers in survivors of appendiceal cancer. However, existing data is limited to small anecdotal reports on appendiceal carcinoid only. We aim to investigate the risk of subsequent malignancies in patients with appendiceal carcinoma and correlate the risk according to patient and clinical characteristics. METHODS: We identified 3788 patients with appendiceal cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database between 1992 and 2011...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27379210/appendiceal-mixed-adeno-neuroendocrine-carcinoma-a-population-based-study-of-the-surveillance-epidemiology-and-end-results-registry
#15
Shayna Brathwaite, Martha M Yearsley, Tanios Bekaii-Saab, Lai Wei, Carl R Schmidt, Mary E Dillhoff, Wendy L Frankel, John L Hays, Christina Wu, Sherif Abdel-Misih
INTRODUCTION: Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently defined by the World Health Organization (WHO) in 2010. Prior to the definition by the WHO, tumors with both adenocarcinoma and neuroendocrine components were given multiple pathological designations making it difficult to characterize the disease. The aim of our study is to better characterize MANEC to better understand its natural history to influence patient care and positively impact outcomes...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27371613/differing-expression-profiles-of-notch-enterocyte-and-wnt-secretory-lineage-signallings-are-associated-with-morphological-diversity-of-appendiceal-tumours
#16
Xianyong Gui, Ziran Meng, Yarrow J McConnell, Shuhong Liu, Vincent G Falck, Lloyd A Mack, Walley J Temple
BACKGROUND: Tumours of appendix, including classic carcinoid tumour (CCT), goblet cell carcinoid (GCC), low-grade appendiceal mucinous neoplasm, high-grade appendiceal mucinous neoplasm/mucinous carcinoma (MCA) and non-mucinous adenocarcinoma (NMA), show different and sometimes mixed morphological features. It was hypothesised that these tumours originate from common tumour stem cell(s) with potential of various cell lineage differentiation. In normal intestinal epithelium, absorptive lineage (enterocytes) differentiation is driven by Notch-Hes1 pathway, while secretory lineage is driven by Wnt-Math1 pathway and further separated by different downstream signallings into three sublineages (Gfi1-Klf4/Elf3 for goblet cells, Gfi1-Sox9 for Paneth cells and Ngn3-Pdx1/Beta2/Pax4 for enteroendocrine cells)...
January 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27338636/adenocarcinoma-ex-goblet-cell-carcinoid-appendiceal-type-crypt-cell-adenocarcinoma-is-a-morphologically-distinct-entity-with-highly-aggressive-behavior-and-frequent-association-with-peritoneal-intra-abdominal-dissemination-an-analysis-of-77-cases
#17
Michelle D Reid, Olca Basturk, Walid L Shaib, Yue Xue, Serdar Balci, Hye-Jeong Choi, Gizem Akkas, Bahar Memis, Brian S Robinson, Bassel F El-Rayes, Charles A Staley, Christopher A Staley, Joshua H Winer, Maria C Russell, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
High-grade versions of appendiceal goblet cell carcinoids ('adenocarcinoma ex-goblet cell carcinoids') are poorly characterized. We herein document 77 examples. Tumors occurred predominantly in females (74%), mean age 55 years (29-84), most with disseminated abdominal (77% peritoneal, 58% gynecologic tract involvement) and stage IV (65%) disease. Many presented to gynecologic oncologists, and nine had a working diagnosis of ovarian carcinoma. Metastases to liver (n=3) and lung (n=1) were uncommon and none arose in adenomatous lesions...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27311320/acute-appendicitis-with-a-neuroendocrine-tumor-g1-carcinoid-pitfalls-of-conservative-treatment
#18
Hiroyuki A Watanabe, Taketoshi Fujimoto, Yo Kato, Mayumi Sasaki, Toshikazu Ikusue
A man in his early thirties presented to our clinic with right lower abdominal pain. Computed tomography (CT) and ultrasonography (US) revealed a swollen appendix and an appendicolith. Abscess formation was not observed but ongoing appendiceal rupture was not ruled out. Three months after successful conservative therapy, the lumen of the apical portion was kept dilated and laparoscopic interval appendectomy was performed. No tumorous findings were observed macroscopically. However, histology revealed many tiny nests infiltrating the submucosa, muscular layer, and subserosa at the root of the appendix...
August 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27306228/neuroendocrine-tumor-of-the-appendix-in-children
#19
Hao Wu, Murali Chintagumpala, John Hicks, Jed G Nuchtern, M Fatih Okcu, Rajkumar Venkatramani
Neuroendocrine tumor (NET) of the appendix is the most common gastrointestinal epithelial tumor in children. The utility of serum markers or the indication for hemicolectomy has not been established in children. In 45 children diagnosed with appendiceal NET, 89% NETs were incidentally found following appendectomy performed for suspected acute appendicitis. The median age was 12 years, and 56% patients were female. Postoperative somatostatin scan (n=5), serum chromogranin A (n=4), and urine 5-HIAA (n=9) were all within normal limits...
March 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27303130/carcinoid-tumour-of-caecum-an-unusual-palpable-mass-in-the-right-iliac-fossa
#20
Mohit M Agrawal, Nandkishor S Sude
Carcinoid tumour represents 0.8-1.5 % of malignant digestive tumours. Gastrointestinal (GI) carcinoids account for 95 % of all the carcinoids, and caecal carcinoids account for 5 % of all the carcinoids. These tumours are frequent in women (2-4:1) as reported by Spallitta and Termine (Minerva Chir 55:77-87, 2002). In order of frequency, they may occur in the appendix (35 %), ileum (28 %), rectum (13 %) and bronchi. Incidence is less than 1 % in the pancreas, gall bladder, liver, larynx, testes and ovaries...
April 2016: Indian Journal of Surgery
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