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metabolic syndrome adolescents

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https://www.readbyqxmd.com/read/28318332/abnormality-of-adipokines-and-endothelial-dysfunction-in-mexican-obese-adolescents-with-insulin-resistance
#1
Maria Del Carmen Ortiz Segura, Blanca Estela Del Río Navarro, Benjamín Antonio Rodríguez Espino, Laurence A Marchat, Fausto Sánchez Muñoz, Santiago Villafaña, Enrique Hong, Fabián Meza-Cuenca, Patrick Mailloux Salinas, Francisco Bolaños-Jiménez, Elena Zambrano, Abel Armando Arredondo-López, Guadalupe Bravo, Fengyang Huang
PURPOSE: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). MATERIALS AND METHODS: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65)...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28316138/irx3-is-a-genetic-modifier-for-birth-weight-adolescent-obesity-and-transaminase-metabolism
#2
C Liu, C Chu, J Zhang, D Wu, D Xu, P Li, Y Chen, B Liu, L Pei, L Zhang, S Liu, T Qi, X-Y Lou, L Li
OBJECTIVE: IRX3 expression has been functionally associated in obesity-associated long-distance susceptibility loci, but the effect of the IRX3 genetic variants on human obesity and obesity-related metabolism remains uncertain. METHODS: To determine the genetic role of IRX3, we conducted a molecular epidemiological analysis using three haplotype tagging single nucleotide polymorphisms (SNPs; rs8053360, rs3751723 and rs12445085) and one nonsynonymous SNP (rs1126960) at the IRX3 locus in 333 junior and senior high school students from a northeast Chinese population...
March 19, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28293638/metabolic-disorders-in-hiv-infected-adolescents-receiving-protease-inhibitors
#3
Jeerunda Santiprabhob, Surapong Tanchaweng, Sirinoot Maturapat, Alan Maleesatharn, Watcharee Lermankul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Kulkanya Chokephaibulkit
Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty adolescents were enrolled [median (IQR) age 16.7 (14.6-18.0) years, 42 males]. Metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM) were found in 8 (10%), 17 (22...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28287410/usefulness-of-the-waist-circumference-to-height-ratio-in-screening-for-obesity-and-metabolic-syndrome-among-korean-children-and-adolescents-korea-national-health-and-nutrition-examination-survey-2010-2014
#4
Dong-Hyun Choi, Yang-Im Hur, Jae-Heon Kang, Kyoungwoo Kim, Young Gyu Cho, Soo-Min Hong, Eun Byul Cho
The aims of this study were to assess the diagnostic value of the weight-to-height ratio (WHtR) for the detection of obesity and metabolic syndrome (MS) in Korean children and adolescents, and to determine the advantages of WHtR as a population-based screening tool in comparison with other obesity indicators, such as body mass index (BMI) and waist circumference (WC). We performed a cross-sectional analysis of data from 3057 children and adolescents (1625 boys, 1332 girls) aged 10-19 years who were included in the fifth Korean National Health and Nutrition Examination Survey (KNHANES, 2010-2012) up to the second year of the sixth KNHANES (2013-2014)...
March 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28285655/correlation-of-metabolic-syndrome-severity-with-cardiovascular-health-markers-in-adolescents
#5
Arthur M Lee, Matthew J Gurka, Mark D DeBoer
BACKGROUND AND OBJECTIVES: The presence of metabolic syndrome (MetS) in childhood is a significant risk factor for later cardiovascular disease (CVD). Recent data showed temporal decreases in a sex- and race/ethnicity-specific MetS severity z-score among U.S. adolescents. Our goal was to characterize the relationship of this MetS z-score with other CVD risk indicators and assess their temporal trends and lifestyle influences. METHODS: We analyzed 4837 participants aged 12-20years from the National Health and Nutrition Examination Survey by 2-year waves from 1999 to 2012...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28284912/metabolic-syndrome-and-atherogenic-indices-in-school-children-a-worrying-panorama-in-brazil
#6
Sandra Maria Barbalho, Marie Oshiiwa, Lia Carolina Sato Fontana, Eder Francisco Ribeiro Finalli, Marcio Emílio Paiva Filho, Ana Paula Machado Spada
BACKGROUND: Metabolic Syndrome (MS) is defined as the combination of a cluster of cardiovascular risk factors. The use of cardiovascular indices such as the ratios TC/HDL-c, LDL-c/HDL-c and TG/HDL-c may help in the assessment of cardiovascular risk. Investigation of cardio-metabolic risks in the pre-adolescent stage is essential to characterize possible patterns for MS in the earliest stages of the life avoiding further irreversible consequences. AIMS: This work aimed to investigate the presence of MS and cardiovascular indices in a group of children aged 6-10 years...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28279074/oxidized-derivatives-of-linoleic-acid-in-pediatric-metabolic-syndrome-is-their-pathogenic-role-modulated-by-the-genetic-background-and-the-gut-microbiota
#7
Domenico Trico, Anna Di Sessa, Sonia Caprio, Naga Chalasani, Wanqing Liu, Tiebing Liang, Joerg Graf, Raimund Herzog, Casey D Johnson, Giuseoppina Rosaria Umano, Ariel Feldstein, Nicola Santoro
AIMS: We tested whether oxidized metabolites of linoleic acid (OXLAM) are associated with pediatric metabolic syndrome (MetS) and a pro-atherogenic lipoprotein profile in 122 obese adolescents. Furthermore, we examined whether genetic and metagenomic factors can modulate plasma OXLAM concentrations by genotyping the Fatty Acid Desaturase 1/2 (FADS) gene and by characterizing the gut microbiota. RESULTS: Subjects with MetS (n=50) showed higher concentrations of 9- and 13-oxooctadecadienoic acid (9- and 13-oxo-ODE) than subjects without MetS (n=72)...
March 9, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28262196/serum-chemerin-in-obese-children-and-adolescents-before-and-after-l-carnitine-therapy-relation-to-nonalcoholic-fatty-liver-disease-and-other-features-of-metabolic-syndrome
#8
Rasha T Hamza, Zeinab A Elkabbany, Ahmed M Shedid, Amira I Hamed, Asmaa O Ebrahim
BACKGROUND AND AIMS: Chemerin plays an important role in metabolic syndrome (MetS) including nonalcoholic fatty liver disease (NAFLD). L-carnitine (LC) may reduce plasma glucose, lipid profile, and improve liver function. The aim of the study was to assess serum chemerin in obese children with suspected NAFLD, the effect of LC on NAFLD grade, chemerin and metabolic profile. METHODS: Fifty obese children were compared to 50 controls. All were subjected to anthropometric assessment, liver function, fasting lipid profile, glucose/insulin (G/I) ratio, homeostasis model assessment (HOMA) index, serum chemerin and abdominal ultrasonography before and after LC...
October 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28256922/obese-adolescents-show-reduced-cognitive-processing-speed-compared-with-healthy-weight-peers
#9
Victoria Sweat, Kathy F Yates, Renee Migliaccio, Antonio Convit
BACKGROUND: Childhood obesity and obesity-associated diabetes and metabolic syndrome (MetS) continue to rise. Obesity has been linked to structural and functional brain abnormalities, particularly in the frontal lobe. METHODS: One hundred sixty-two adolescents (aged 19.53 ± 1.53 years) underwent medical, neurocognitive, and brain magnetic resonance imaging assessments. Participants were either healthy weight (BMI <25.0 kg/m(2) or BMI percentile <85%) or obese (BMI ≥30...
March 3, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28256379/outcome-of-childhood-onset-epilepsy-from-adolescence-to-adulthood-transition-issues
#10
REVIEW
R Nabbout, D M Andrade, N Bahi-Buisson, H Cross, I Desquerre, O Dulac, T Granata, E Hirsch, V Navarro, L Ouss, P L Pearl, D Schmidt, E Thiele, P R Camfield, C S Camfield
This is the second of three papers that summarize the second symposium on Transition in Epilepsies held in Paris in June 2016. This paper addresses the outcome for some particularly challenging childhood-onset epileptic disorders with the goal of recommending the best approach to transition. We have grouped these disorders in five categories with a few examples for each. The first group includes disorders presenting in childhood that may have late- or adult-onset epilepsy (metabolic and mitochondrial disorders)...
February 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28242438/heritability-parental-transmission-and-environment-correlation-of-pediatric-onset-type-2-diabetes-mellitus-and-metabolic-syndrome-related-traits
#11
América L Miranda-Lora, Jenny Vilchis-Gil, Mario Molina-Díaz, Samuel Flores-Huerta, Miguel Klünder-Klünder
AIM: To estimate the heritability, parental transmission and environmental contributions to the phenotypic variation in type 2 diabetes mellitus and metabolic syndrome-related traits in families of Mexican children and adolescents. METHODS: We performed a cross-sectional study of 184 tri-generational pedigrees with a total of 1160 individuals (99 families with a type 2 diabetes mellitus proband before age 19). The family history of type 2 diabetes mellitus in three generations was obtained by interview...
February 10, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28236585/the-importance-of-genetic-counseling-and-genetic-screening-a-case-report-of-a-16-year-old-boy-with-resistant-hypertension-and-severe-hypokalemia
#12
Ze-Min Kuang, Ying Wang, Jia-Jie Wang, Jing-Hua Liu, Rong Zeng, Qi Zhou, Zhen-Qiu Yu, Long Jiang
Liddle's syndrome, an autosomal dominant form of monogenic hypertension, is characterized by salt-sensitive hypertension with early penetrance, hypokalemia, metabolic alkalosis, suppression of plasma rennin activity and aldosterone secretion, and a clear-cut response to epithelial sodium channel blockers but not spironolactone therapy. Here, we describe the case of a 16-year-old boy patient with resistant hypertension (maintain 170-180/100-110 mm Hg after administration four kinds of antiypertensive drugs) and severe hypokalemia...
February 3, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28226031/evaluation-of-clinical-and-laboratory-markers-of-cardiometabolic-risk-in-overweight-and-obese-children-and-adolescents
#13
Heloísa Marcelina da Cunha Palhares, Adriana Paula da Silva, Daniela Cristina Silva Resende, Gilberto de Araújo Pereira, Virmondes Rodrigues, Maria de Fátima Borges
OBJECTIVE: This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents. METHODS: The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels)...
January 1, 2017: Clinics
https://www.readbyqxmd.com/read/28225503/association-of-serum-ferritin-with-insulin-resistance-abdominal-obesity-and-metabolic-syndrome-in-korean-adolescent-and-adults-the-korean-national-health-and-nutrition-examination-survey-2008-to-2011
#14
Young Suk Shim, Min Jae Kang, Yeon Jeong Oh, Joon Woo Baek, Seung Yang, Il Tae Hwang
This study aimed to evaluate the associations of serum ferritin with insulin resistance indices, body fat mass/percentage, and all the components of metabolic syndrome (MetS), as well as the risk for MetS according to serum ferritin levels in Korean adolescents and adults.A total of 15,963 Korean males and females aged 16 to 80 years were analyzed using data from the Korean National Health and Nutrition Examination Survey, 2005 to 2011.The median serum ferritin concentration was 98.82 ng/mL for males and 38...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28223816/prevalence-of-metabolic-syndrome-in-adolescents-living-in-mthatha-south-africa
#15
Morongwe Annah Sekokotla, Nandu Goswami, Constance Rufaro Sewani-Rusike, Jehu Erapu Iputo, Benedicta Ngwenchi Nkeh-Chungag
OBJECTIVE: Metabolic syndrome (MetS), defined as the clustering of three of five risk factors (hypertension, obesity, triglyceridemia, dyslipidemia and hyperglycemia), is being increasingly mentioned among children and adolescents despite there being no consensus on how it should be defined in this set of population. Furthermore, very few studies have focused on MetS in children and adolescents in sub-Saharan populations. This study, therefore, aimed at determining the prevalence of the MetS and contributing risk in adolescents living in Mthatha, South Africa...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28218824/decreased-home-cage-movement-and-oromotor-impairments-in-adult-fmr1-ko-mice
#16
Stephen J Bonasera, Tammy R Chaudoin, Evan H Goulding, Mateusz Mittek, Anna Dunaevsky
Fragile X syndrome (FXS) is a common inherited disorder that significantly impacts family and patient day-to-day living across the entire lifespan. The childhood and adolescent behavioral consequences of FXS are well-appreciated. However, there are significantly fewer studies (except those examining psychiatric comorbidities) assessing behavioral phenotypes seen in adults with FXS. Mice engineered with a genetic lesion of Fmr1 recapitulate important molecular and neuroanatomical characteristics of FXS, and provide a means to evaluate adult behavioral phenotypes associated with FXS...
February 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28215263/sleep-disordered-breathing-systemic-adipokine-secretion-and-metabolic-dysregulation-in-overweight-and-obese-children-and-adolescents
#17
Annelies Van Eyck, Kim Van Hoorenbeeck, Benedicte Y De Winter, Luc Van Gaal, Wilfried De Backer, Stijn L Verhulst
OBJECTIVE: Obstructive sleep apnea (OSA) is common among overweight and obese children, and it is an independent risk factor for developing metabolic syndrome. However, the mechanisms linking OSA and metabolic syndrome are still unclear, but a role for adipose tissue dysfunction caused by intermittent hypoxia has been suggested. Therefore, the goal of this study was to investigate the relationship between OSA and systemic adipokine concentrations in overweight and obese children. METHODS: We included 164 overweight and obese children in a tertiary center and distributed them in groups based on their obstructive apnea-hypopnea index (111 controls, 28 mild OSA, 25 moderate-to-severe OSA)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28202261/hyperprolinemia-as-a-clue-in-the-diagnosis-of-a-patient-with-psychiatric-manifestations
#18
Marco Duarte, Joana Afonso, Ana Moreira, Diana Antunes, Cristina Ferreira, Hildeberto Correia, Margarida Marques, Sílvia Sequeira
Lately, microdeletions of the 22q region, responsible for DiGeorge syndrome or velocardiofacial syndrome, have been increasingly related to neuropsychiatric disorders including schizophrenia and bipolar disorder. These manifestations seem to be related to certain genes located in the hemideleted region such as the proline dehydrogenase (PRODH) and the catechol-o-methyltransferase (COMT) genes. We describe a teenager who started his adolescent psychiatric care presenting cognitive impairment, irritable mood and aggressive behaviour with schizophrenia-like symptoms that scored 153 in the Positive and Negative Symptoms Scale (PANSS) assessment...
February 12, 2017: Brain & Development
https://www.readbyqxmd.com/read/28196853/impaired-cardiac-and-skeletal-muscle-bioenergetics-in-children-adolescents-and-young-adults-with-barth-syndrome
#19
Adil Bashir, Kathryn L Bohnert, Dominic N Reeds, Linda R Peterson, Adam J Bittel, Lisa de Las Fuentes, Christina A Pacak, Barry J Byrne, W Todd Cade
Barth syndrome (BTHS) is an X-linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with BTHS and unaffected controls and examine their relationships with cardiac function and exercise capacity. Children/adolescents and young adults with BTHS (n = 20) and children/adolescent and young adult control participants (n = 23, total n = 43) underwent (31)P magnetic resonance spectroscopy ((31)P-MRS) of the lower extremity (calf) and heart for estimation of skeletal muscle and cardiac bioenergetics...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28193574/effects-of-preterm-birth-and-fetal-growth-retardation-on-life-course-cardiovascular-risk-factors-among-schoolchildren-from-colombia-the-fuprecol-study
#20
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Emilio Villa-González, Javier Martínez-Torres, Anthony C Hackney, Antonio García-Hermoso
BACKGROUND: Both fetal growth restriction and prematurity have been associated with cardiometabolic risk in youth and adults, however, data on their combined effects on cardiometabolic health in youth are scarce. AIMS: This study aimed at assessing the effects of birth weight and gestational age combined on life-course cardiovascular risk factors and obesity among schoolchildren from Colombia. STUDY DESIGN: A cross-sectional study. SUBJECTS: Participants comprised 2510 Colombian schoolchildren (54...
February 10, 2017: Early Human Development
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