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metabolic syndrome adolescents

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https://www.readbyqxmd.com/read/29768692/prevalence-of-subclinical-hypothyroidism-in-obese-children-or-adolescents-and-association-between-thyroid-hormone-and-the-components-of-metabolic-syndrome
#1
Hye Young Jin
AIM: Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free thyroxine (fT4), and its clinical significance is unclear. The purpose of this study is to investigate the prevalence of subclinical hypothyroidism in children and adolescents and determine the relationship between lipid profiles, insulin resistance and thyroid hormones. METHODS: A retrospective, cross-sectional study was performed using data from a subset of the KNHANES VI...
May 16, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29759068/childhood-retinol-binding-protein-4-rbp4-levels-predicting-the-10-year-risk-of-insulin-resistance-and-metabolic-syndrome-the-bcams-study
#2
Ge Li, Issy C Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao, Steven M Willi
BACKGROUND: Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are lacking. We investigated whether RBP4 levels during childhood predict cardiometabolic risk at 10-year follow-up. METHODS: The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study...
May 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29755364/early-effects-of-a-low-fat-fructose-rich-diet-on-liver-metabolism-insulin-signaling-and-oxidative-stress-in-young-and-adult-rats
#3
Raffaella Crescenzo, Luisa Cigliano, Arianna Mazzoli, Rosa Cancelliere, Rosa Carotenuto, Margherita Tussellino, Giovanna Liverini, Susanna Iossa
The increase in the use of refined food, which is rich in fructose, is of particular concern in children and adolescents, since the total caloric intake and the prevalence of metabolic syndrome are increasing continuously in these populations. Nevertheless, the effects of high fructose diet have been mostly investigated in adults, by focusing on the effect of a long-term fructose intake. Notably, some reports evidenced that even short-term fructose intake exerts detrimental effects on metabolism. Therefore, the aim of this study was to compare the metabolic changes induced by the fructose-rich diet in rats of different age, i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29752170/treating-obstructive-sleep-apnea-and-chronic-intermittent-hypoxia-improves-the-severity-of-nonalcoholic-fatty-liver-disease-in-children
#4
Shikha S Sundaram, Ann C Halbower, Jelena Klawitter, Zhaoxing Pan, Kristen Robbins, Kelley E Capocelli, Ronald J Sokol
OBJECTIVE: To determine the effects of treating obstructive sleep apnea/nocturnal hypoxia on pediatric nonalcoholic fatty liver disease (NAFLD) severity and oxidative stress. STUDY DESIGN: Biopsy proven participants (n = 9) with NAFLD and obstructive sleep apnea/hypoxia were studied before and after treatment with continuous positive airway pressure (CPAP) for sleep disordered breathing, including laboratory testing and markers of oxidative stress, urine F(2)-isoprostanes...
May 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29750655/metabolic-risk-factors-in-adolescent-girls-with-type-1-diabetes
#5
Cíntia Castro-Correia, Rita Santos-Silva, Marta Pinheiro, Carla Costa, Manuel Fontoura
BACKGROUND: The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status. METHODS: We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29732027/paraoxonase-activity-in-metabolic-syndrome-in-children-and-adolescents
#6
Arati Adhe-Rojekar, Mukund Ramchandra Mogarekar, Mohit Vijay Rojekar
Background: Metabolic syndrome (MetS) is a collection of various interrelated risk factors that appear to have an impact as development of atherosclerotic cardiovascular disease (CVDs). Epidemic of childhood and adolescent's obesity has increased interest in the metabolic syndrome (MS) due to the potential projection into adulthood. The prevalence of MS in adolescents has been estimated to be 6.7% in young adults and 4.2% in adolescents. We aimed to study the MetS in children and adolescents with respect to metabolic changes...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29726288/association-of-melatonin-receptor-1-b-gene-rs10830963-and-rs9192552-polymorph%C3%A4-sm-with-adolescent-obesity-and-related-comorbidities-in-turkey
#7
Nilgün Çöl, Muradiye Nacak, Mustafa Araz
Objective To examine the role of rs10830963 and rs8192552 polymorphisms in melatonin receptor 1 B (MTNR1B) gene on the development of obesity and related comorbidities among adolescents in South-Eastern Turkey. Methods The present study included 200 unrelated adolescents (100 obese, 100 normal weight). The rs8192552 and rs10830963 polymorphisms in the MTNR1B gene were genotyped using a PCR SNaPshot assay. Results No statistically significant association was observed between MTNR1B gene rs8192552/rs10830963 polymorphisms and adolescent obesity...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29710196/long-term-outcomes-of-pediatric-onset-hypertrophic-cardiomyopathy-and-age-specific-risk-factors-for-lethal-arrhythmic-events
#8
Niccolò Maurizi, Silvia Passantino, Gaia Spaziani, Francesca Girolami, Anna Arretini, Mattia Targetti, Iva Pollini, Alessia Tomberli, Silvia Pradella, Giovanni Battista Calabri, Veronica Vinattieri, Bruno Bertaccini, Ornella Leone, Luciano De Simone, Claudio Rapezzi, Niccolò Marchionni, Franco Cecchi, Silvia Favilli, Iacopo Olivotto
Importance: Predictors of lethal arrhythmic events (LAEs) after a pediatric diagnosis of hypertrophic cardiomyopathy (HCM) are unresolved. Existing algorithms for risk stratification are limited to patients older than 16 years because of a lack of data on younger individuals. Objective: To describe the long-term outcome of pediatric-onset HCM and identify age-specific arrhythmic risk factors. Design, Setting, and Participants: This study assessed patients with pediatric-onset hypertrophic cardiomyopathy diagnosed from 1974 to 2016 in 2 national referral centers for cardiomyopathies in Florence, Italy...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29705673/ace-apoa5-and-mtp-gene-polymorphisms-analysis-in-relation-to-triglyceride-and-insulin-levels-in-pediatric-patients
#9
Lilia Carranza-González, Rafael B R León-Cachón, María Antonia González-Zavala, Clara Ríos-Ibarra, Jesús Morlett-Chávez, Celia Sánchez-Domínguez, Ana Cepeda-Nieto, Mauricio Salinas-Santander
BACKGROUND AND AIMS: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation...
April 25, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29705051/intra-abdominal-fat-measurement-by-ultrasonography-association-with-anthropometry-and-metabolic-syndrome-in-adolescents
#10
Rommel L R Novais, Ana Carolina C Café, Aisha A Morais, Wendell C Bila, Gilson D da S Santos, Carlos Alexandre de O Lopes, Vinícius S Belo, Márcia Christina C Romano, Joel A Lamounier
OBJECTIVE: To associate intra-abdominal fat thickness measured by ultrasonography to the factors related to metabolic syndrome and to determine cutoff points of intra-abdominal fat measurement associated with a greater chance of metabolic syndrome in adolescents. METHODS: This was a cross-sectional study, with 423 adolescents from public schools. Intra-abdominal fat was measured by ultrasonography. Anthropometric data were collected, and biochemical analyses were performed...
April 26, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29700992/waist-to-height-ratio-as-a-risk-marker-for-metabolic-syndrome-in-childhood-a-meta-analysis
#11
C Ochoa Sangrador, J Ochoa-Brezmes
BACKGROUND: Individuals with abdominal obesity have a higher cardiovascular risk, regardless of the degree of global overweight. OBJECTIVE: To estimate the accuracy of the Waist/height ratio (WtHR) as a risk marker for metabolic syndrome (MS) in children or adolescents. METHODS: Published cohort or cross-sectional studies (Pubmed, Embase-SCOPUS and CINAHL) were searched, with no limits of time. Studies providing Waist/height ratio and clustered criteria of metabolic syndrome were included...
April 26, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29699814/dxa-measured-visceral-fat-mass-and-lean-body-mass-reflect-abnormal-metabolic-phenotypes-among-some-obese-and-nonobese-chinese-children-and-adolescents
#12
W Q Ding, J T Liu, Y X Shang, B Gao, X Y Zhao, H P Zhao, W J Wu
BACKGROUND AND AIM: The exact constellation of body composition characteristics among metabolically unhealthy obese (MUO) and nonobese (MUNO) children and adolescents remains unclear. The purpose of this study was to identify the major body composition determinants of metabolically unhealthy phenotypes among Chinese children and adolescents. METHODS AND RESULTS: We used data from a cross-sectional survey in 2015 that included 1983 children and adolescents aged 6-18 years...
March 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29670474/positive-effect-of-fermented-camel-milk-on-liver-enzymes-of-adolescents-with-metabolic-syndrome-a-double-blind-randomized-cross-over-trial
#13
Zahra Fallah, Awat Feizi, Mahin Hashemipour, Roya Kelishadi
Background: Metabolic syndrome (MetS) has several health consequences. Liver enzymes elevation is among them. Aim: This study aimed to assess the effects of fermented Camel milk (FCM), as a functional food and dairy, on some features of MetS in adolescents including liver enzymes status, serum lipids and anthropometric measures. Methods: Overweight/obese adolescents with MetS were randomly assigned to FCM 250 cc per day for 8 weeks, a 4-week washout, and then to diluted Cow's yogurt (DCY) 250 cc per day for 8 weeks, or the reverse sequence...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29668472/obesity-in-childhood-and-adolescence-genetic-factors
#14
Marko Kostovski, Velibor Tasic, Nevena Laban, Momir Polenakovic, Dragan Danilovski, Zoran Gucev
Obesity and excess weight are a pandemic phenomenon in the modern world. Childhood and adolescent obesity often ends up in obesity in adults. The costs of obesity and its consequences are staggering for any society, crippling for countries in development. Childhood obesity is also widespread in Macedonia. Metabolic syndrome, dyslipidemia and carbohydrate intolerance are found in significant numbers. Parents and grandparents are often obese. Some of the children are either dysmorphic, or slightly retarded. We have already described patients with Prader-Willi syndrome, Bardet-Biedl syndrome or WAGR syndrome...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29651819/biochemical-predictors-of-early-onset-non-alcoholic-fatty-liver-disease-in-young-children-with-obesity
#15
Ju Young Kim, Jinmin Cho, Hye Ran Yang
BACKGROUND: The prevalence of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) and their associated risk factors are not well-established in young children with obesity. The purpose of this study was to evaluate the prevalence of early onset NAFLD and identify its biochemical predictors in obese children aged less than 10 years. METHODS: Anthropometric measurements, blood pressure, laboratory tests, and abdominal ultrasonography (USG) were performed in all subjects...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29648906/the-effects-of-a-community-based-lifestyle-intervention-on-metabolic-syndrome-and-its-components-in-adolescents-findings-of-a-decade-follow-up
#16
Parisa Amiri, Sara Jalali-Farahani, Hasti Masihay Akbar, Leila Cheraghi, Davood Khalili, Amirabbas Momenan, Parvin Mirmiran, Arash Ghanbarian, Mehdi Hedayati, Firoozeh Hosseini-Esfahani, Fereidoun Azizi
BACKGROUND: The increasing prevalence of metabolic syndrome (MetS) in childhood makes lifestyle interventions imperative during adolescence. This study aimed to assess the effects of a community-based lifestyle intervention on MetS and its components in adolescents. METHODS: Adolescents, based on their residential area were categorized into three groups: complete intervention (residing in the intervention area at baseline and during all follow-ups), incomplete intervention (residing in either the intervention or control areas and were in transition between these two areas), and control group (residing in the control area at baseline and throughout all follow-ups)...
April 12, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29619157/glomerular-hyperfiltration-as-predictor-of-cardiometabolic-risk-factors-among-children-and-adolescents-the-childhood-and-adolescence-surveillance-and-prevention-of-adult-v-study
#17
Roya Kelishadi, Mostafa Qorbani, Farahnak Assadi, Mohammad Esmaeil Motlagh, Shirin Djalalinia, Ali Shahsavari, Hasan Ziaodini, Majzoubeh Taheri, Gita Shafiee, Azadeh Aminianfar, Sajjad Esmaeili, Tahereh Aminaei, Morteza Mansourian, Ramin Heshmat
Background: The prevalence of glomerular hyperfiltration and chronic kidney disease is increasing worldwide in parallel with obesity hypertension epidemic. The effect of increases in glomerular filtrations (GFR) in children with metabolic syndrome has not been studied. The purpose of the present study is to investigate the relationship between GFR and cardiometabolic risk factors in a large sample of pediatric population. Methods: In this nationwide survey, 3800 participants were selected by cluster random sampling from 30 provinces in Iran...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29607525/remission-of-loss-of-control-eating-and-changes-in-components-of-the-metabolic-syndrome
#18
Lisa M Shank, Marian Tanofsky-Kraff, Rachel M Radin, Lauren B Shomaker, Denise E Wilfley, Jami F Young, Sheila Brady, Cara H Olsen, James C Reynolds, Jack A Yanovski
OBJECTIVE: Pediatric loss of control (LOC) eating prospectively predicts the worsening of metabolic syndrome components. However, it is unknown if remission of LOC eating is associated with improvements in metabolic health. Therefore, we conducted a secondary analysis of a trial that enrolled adolescent girls with LOC eating, examining whether LOC remission (vs. persistence) at end-of-treatment was associated with changes in metabolic syndrome components at 6-month follow-up. METHOD: One hundred three adolescent girls (age 14...
April 1, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29590081/metabolic-syndrome-leptin-insulin-resistance-and-uric-acid-a-trinomial-foe-for-algerian-city-dweller-adolescents-health
#19
Hamida Bouhenni, Hadjer Daoudi, Haidar Djemai, Abdelkader Rouabah, Damien Vitiello, Leila Rouabah
Background Adolescence is one of the critical periods where increased risk for long-term obesity-related complications is an important health concern. This highlights the need to perform early diagnostics based on precise biomarkers to decrease the risk of complications in adolescents with obesity. Objective To determine the relationships between serum levels of uric acid (UA), leptin and insulin with metabolic syndrome (MS) components in Algerian adolescents. Subjects Nondiabetic adolescents (n = 204)...
March 28, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29588960/the-relationship-between-d-beta-hydroxybutyrate-blood-concentrations-and-seizure-control-in-children-treated-with-the-ketogenic-diet-for-medically-intractable-epilepsy
#20
Jeffrey R Buchhalter, Sabrina D'Alfonso, Mary Connolly, Ernest Fung, Aspasia Michoulas, David Sinasac, Rachel Singer, Jacklyn Smith, Narender Singh, Jong M Rho
Objective: The ketogenic diet (KD) is a proven treatment for drug-resistant (DR) seizures in children and adolescents. However, the relationship between seizure control and the most commonly measured metabolite of the diet, the ketone body d-beta-hydroxybutyrate (D-BHB), is controversial. This study was performed to clarify the relationship because specific ketone bodies may be useful as biomarkers of diet efficacy. Methods: Families of children with DR seizures were approached for participation in this open-label, prospective study when they were referred for the KD at two western Canadian children's hospitals...
September 2017: Epilepsia open
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