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metabolic syndrome adolescents

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https://www.readbyqxmd.com/read/29353275/endocrine-and-metabolic-disturbances-in-survivors-of-hematopoietic-stem-cell-transplantation-in-childhood-and-adolescence
#1
Shlomit Shalitin, Lihi Pertman, Michal Yackobovitch-Gavan, Isaac Yaniv, Yael Lebenthal, Moshe Phillip, Jerry Stein
BACKGROUND/AIMS: The objective was to evaluate endocrine complications in survivors of hematopoietic stem cell transplantation (HSCT) performed during childhood. METHODS: Endocrine dysfunction and metabolic syndrome parameters were assessed by chart review of 178 childhood HSCT survivors (median age at evaluation, 15.5 [range: 3.8-29.8] years; median follow-up, 8.5 [range: 2-23.4] years). RESULTS: The following statistically significant associations were identified (p < 0...
January 19, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29344657/effects-of-hereditary-moderate-high-fat-diet-on-metabolic-performance-and-physical-endurance-capacity-in-c57bl-6-offspring
#2
Fang Liu, Guirong Zhang, Xue Sheng, Shang Liu, Meng Cui, Heyun Guo, Jianbin Xue, Lingyun Zhang
Obesity in pregnant women presents a risk to fetal health, leading to numerous metabolic syndromes and chronic inflammation risks. Previously, physical exercise was considered to be one of the primary treatments for obesity. However, the effect of fat consumption throughout the life cycle on physical endurance capacity remains unknown. A total of two groups of female mice (age, 6 weeks; C57BL/6J) were fed with a normal chow diet and a moderate high fat diet (MHFD), during pregnancy and lactation (8 weeks), with the offspring receiving the same diet as the mother...
January 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29338791/associations-of-the-hypertension-related-single-nucleotide-polymorphism-rs11191548-with-high-density-lipoprotein-cholesterol-and-leptin-in-chinese-children
#3
Lijun Wu, Liwang Gao, Xiaoyuan Zhao, Meixian Zhang, Jianxin Wu, Jie Mi
BACKGROUND: The genome-wide association study has founded hypertension-related single nucleotide polymorphism (SNP) rs11191548 near CYP17A1 encoding a key enzyme involved in steroid metabolism, but the molecular mechanisms are not understood and the associations of the SNP with hypertension-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNP and two hypertension-related traits, lipids and leptin...
January 16, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29334985/role-of-sleep-duration-and-sleep-related-problems-in-the-metabolic-syndrome-among-children-and-adolescents
#4
Leonardo Pulido-Arjona, Jorge Enrique Correa-Bautista, Cesar Agostinis-Sobrinho, Jorge Mota, Rute Santos, María Correa-Rodríguez, Antonio Garcia-Hermoso, Robinson Ramírez-Vélez
BACKGROUND: There is increasing recognition that sleep is a risk factor for metabolic syndrome (MetS). The aim of the present study was to analyze the relationship between self-reported sleep duration, sleep-related problems and the presence of MetS in children and adolescents from Bogotá, D.C., Colombia. METHODS: This is a cross-sectional analysis from the FUPRECOL study (2014-15). Participants included 2779 (54.2% girls) youth from Bogota (Colombia). MetS was defined as the presence of ≥3 of the metabolic abnormalities (hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol [HDL-c], hypertension, and increased waist circumference) according to the criteria of de Ferranti/Magge and colleges...
January 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29333826/vitamin-d-deficiency-in-pediatric-clinical-practice
#5
Gustavo Cediel, Johanna Pacheco-Acosta, Carlos CastiUo-Durdn
INTRODUCTION: Vitamin D research suggests it has a role in disorders other than bone metabolism. OBJECTIVE: To update the information on vitamin D deficiency (VDD) in pediatric clinical disorders. METHODS: Search in virtual libraries, giving priority to clinical and longitudinal studies and meta-analyses on VDD in the pediatric age group published in the past 20 years. The terms "vitamin D deficiency", "children and adolescents" (both in Spanish and English) were used as search descriptors...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29329105/daily-sitting-time-associated-with-the-risk-of-metabolic-syndrome-in-korean-adolescents
#6
Ki Nam Bae, Hye Ryun Kim, Young-Jun Rhie, Kee-Hyoung Lee, Hyo-Kyoung Nam
BACKGROUND: This study aimed to investigate the relationship between daily sitting time and the risk of metabolic syndrome in Korean adolescents. METHODS: Data from 486 adolescents aged 12-18 years were obtained from national surveys. Daily sitting time was measured using questionnaires and divided into three intervals: <8 h; 8-12 h; and ≥12 h. RESULTS: The mean daily sitting time and prevalence of positive metabolic components were 620...
January 12, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29320413/adherence-to-the-mediterranean-diet-and-inflammatory-markers
#7
Antoni Sureda, Maria Del Mar Bibiloni, Alicia Julibert, Cristina Bouzas, Emma Argelich, Isabel Llompart, Antoni Pons, Josep A Tur
The aim was to assess inflammatory markers among adults and adolescents in relation to the adherence to the Mediterranean diet. A random sample (219 males and 379 females) of the Balearic Islands population (12-65 years) was anthropometrically measured and provided a blood sample to determine biomarkers of inflammation. Dietary habits were assessed and the adherence to the Mediterranean dietary pattern calculated. The prevalence of metabolic syndrome increased with age in both sexes. The adherence to the Mediterranean diet in adolescent males was 51...
January 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29306931/decrease-in-serum-chemerin-through-aerobic-exercise-plus-dieting-and-its-association-with-mitigation-of-cardio-metabolic-risk-in-obese-female-adolescents
#8
Min Liu, Xiaojing Lin, Xiaohui Wang
BACKGROUND: The objective of this study was to determine the effects of a 4-week aerobic exercise plus dieting intervention on serum chemerin in obese female adolescents and its possible role in mitigating cardio-metabolic risk including glucose and lipid metabolism, central fat and inflammation. METHODS: Fifty obese female adolescents were randomly divided into two groups: exercise plus dieting group (n=30) and dieting group (n=20). The participants in the exercise plus dieting group completed 4 weeks of moderate aerobic exercise combined with dieting, while the subjects in the dieting group undertook only dieting...
January 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29305232/comparison-of-different-maximal-oxygen-uptake-equations-to-discriminate-the-cardiometabolic-risk-in-children-and-adolescents
#9
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Jorge Mota, Antonio Garcia-Hermoso
OBJECTIVE: To determine the ability of 8 different maximal oxygen uptake (VO2max) equations to discriminate between low and high cardiometabolic risk, and to determine cardiorespiratory fitness (CRF) cutoffs associated with a more favorable cardiometabolic risk profile in Colombian children and adolescents. STUDY DESIGN: In a cross-sectional study, CRF was estimated using the 20-m shuttle run test in 2870 schoolchildren (54.5% girls) from Bogota, Colombia. We computed a metabolic syndrome score (MetScore) as the sum of the age- and sex-standardized scores of waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood pressure...
January 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29298340/the-association-between-a-body-shape-index-and-cardiovascular-risk-in-overweight-and-obese-children-and-adolescents
#10
Chiara Mameli, Nir Y Krakauer, Jesse C Krakauer, Alessandra Bosetti, Chiara Matilde Ferrari, Norma Moiana, Laura Schneider, Barbara Borsani, Teresa Genoni, Gianvincenzo Zuccotti
A Body Shape Index (ABSI) and normalized hip circumference (Hip Index, HI) have been recently shown to be strong risk factors for mortality and for cardiovascular disease in adults. We conducted an observational cross-sectional study to evaluate the relationship between ABSI, HI and cardiometabolic risk factors and obesity-related comorbidities in overweight and obese children and adolescents aged 2-18 years. We performed multivariate linear and logistic regression analyses with BMI, ABSI, and HI age and sex normalized z scores as predictors to examine the association with cardiometabolic risk markers (systolic and diastolic blood pressure, fasting glucose and insulin, total cholesterol and its components, transaminases, fat mass % detected by bioelectrical impedance analysis) and obesity-related conditions (including hepatic steatosis and metabolic syndrome)...
2018: PloS One
https://www.readbyqxmd.com/read/29290474/triglycerides-high-density-lipoprotein-cholesterol-ratio-as-a-cardiometabolic-risk-marker-in-children-and-adolescents-from-m%C3%A3-rida-city-venezuela
#11
Miguel Aguirre, Yajaira Briceño, Roald Gómez-Pérez, Yajaira Zerpa, Nolis Camacho, Mariela Paoli
OBJECTIVE: To determine the behavior of the triglycerides/HDL-cholesterol ratio (TG/HDL) as a cardiometabolic risk marker in children and adolescents from Mérida, Venezuela. METHODS: A total of 1292 children and adolescents aged 7-18 years who attended educational institutions in the Libertador Municipality were enrolled into this study. Anthropometric measurements and blood pressure values were recorded. Fasting blood glucose, insulin and lipid levels were measured...
December 28, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29280741/insulin-resistance-prediabetes-metabolic-syndrome-what-should-every-pediatrician-know
#12
Ahmad Ighbariya, Ram Weiss
The Metabolic syndrome describes a clustering of typical cardiovascular risk factors. The syndrome is also known as "Insulin Resistance syndrome" as a substantial part of the pathophysiology is driven by resistance to the metabolic effects of insulin. The major cause of insulin resistance in childhood is a typical lipid partitioning pattern characterized by increased deposition of lipids within insulin responsive tissues, such as the liver and skeletal muscle and within the viscera. This lipid deposition pattern is also associated with infiltration of intra-abdominal tissues with cells of the immune system, inducing systemic, low-grade inflammation typically observed in insulin resistant obese children and adolescents...
December 27, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29273941/associations-between-metabolic-syndrome-components-and-markers-of-inflammation-in-welsh-school-children
#13
Non Eleri Thomas, David A Rowe, Elaine M Murtagh, Jeffrey W Stephens, Rhys Williams
We investigated the multivariate dimensionality and strength of the relationship between metabolic syndrome (MetS) and inflammation in children. Caucasian school children (N = 229; 12-14 years) from Wales were tested on several health indicators including measures of body composition, inflammation, fasting glucose regulation, blood pressure, and lipids. The multivariate association between MetS and inflammation was investigated via canonical correlation analysis. Data were corrected for non-normality by log transformation, and sex-specific z-scores computed for variables where there was a significant sex difference...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29247169/cardiometabolic-risk-factors-in-childhood-adolescent-and-young-adult-survivors-of-acute-lymphoblastic-leukemia-a-petale-cohort
#14
Emile Levy, Mariia Samoilenko, Sophia Morel, Jade England, Devendra Amre, Laurence Bertout, Simon Drouin, Caroline Laverdière, Maja Krajinovic, Daniel Sinnett, Geneviève Lefebvre, Valérie Marcil
Our objectives were to assess the prevalence of cardiometabolic complications in children, adolescents, and young adult survivors of childhood acute lymphoblastic leukemia (cALL), to identify their predictors and the risk compared to the Canadian population. We performed a cardiometabolic assessment of cALL survivors from the PETALE cohort (n = 247, median age at visit of 21.7 years). In our group, overweight and obesity affected over 70% of women. Pre-hypertension and hypertension were mostly common in men, both adults (20%) and children (19%)...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241749/acne-vulgaris-the-metabolic-syndrome-of-the-pilosebaceous-follicle
#15
Bodo C Melnik
Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and represents the most common skin disease affecting about 85% of adolescents in Westernized populations. Acne vulgaris is primarily a disease of wealthy countries and exhibits higher prevalence rates in developed compared with developing countries. No acne has been found in non-Westernized populations still living under Paleolithic dietary conditions constraining hyperglycemic carbohydrates, milk, and dairy products. The high prevalence rates of adolescent acne cannot be explained by the predominance of genetic factors but by the influence of a Western diet that overstimulates the key conductor of metabolism, the nutrient- and growth factor-sensitive kinase mTORC1...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29231963/body-composition-in-long-term-survivors-of-acute-lymphoblastic-leukemia-diagnosed-in-childhood-and-adolescence-a-focus-on-sarcopenic-obesity
#16
Christopher J C Marriott, Lesley F Beaumont, Troy H Farncombe, Amy N Cranston, Uma H Athale, Valerie N Yakemchuk, Colin E Webber, Ronald D Barr
BACKGROUND: The late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity. METHODS: A cross-sectional study of body composition was undertaken via dual-energy x-ray absorptiometry in 75 long-term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat-free mass (equivalent to the lean body mass [LBM]), and whole-body bone mineral content...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29231926/predictors-of-physical-fitness-among-southwestern-native-american-adolescents-at-risk-for-diabetes
#17
M D Ehrhart, V Shah, L Colip, P Sandy, D Ghahate, J Bobelu, T Faber, M R Burge
The prevalence of obesity is increasing among children nationally. Native American children from Zuni Pueblo appear to be at increased risk for obesity, which also increases the risk for the metabolic syndrome, diabetes, and cardiovascular disease. While exercise and physical fitness can prevent or forestall these developments, predictors of physical fitness in this population are unknown. Forty-seven Native American adolescents completed four aspects of the Presidential Fitness Challenge (push-ups, sit-ups, step-ups, and timed walking) during screening for another study, and fitness was empirically summarized with a Presidential Fitness Index...
2017: J Pediatr Endocrinol (Jersey City)
https://www.readbyqxmd.com/read/29220530/impaired-lipolysis-diminished-fat-oxidation-and-metabolic-inflexibility-in-obese-girls-with-polycystic-ovary-syndrome
#18
Joon Young Kim, Hala Tfayli, Sara F Michaliszyn, Silva Arslanian
CONTEXT: Metabolic flexibility reflects the ability to switch from lipid to carbohydrate oxidation during insulin stimulation manifested in increased respiratory quotient (RQ). Despite insulin resistance in glucose metabolism in PCOS women and adolescents, little is known about adipose tissue metabolism and metabolic flexibility. OBJECTIVE: To investigate whole-body lipolysis, substrate oxidation and metabolic flexibility in obese PCOS vs. non-PCOS girls. PATIENTS/DESIGN: Twenty-one obese (BMI 32...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29218646/cardiovascular-and-metabolic-complications-diagnosis-and-management-in-obese-children
#19
REVIEW
Naval K Vikram
The world at present is facing a burden of rising prevalence of obesity in children and adolescents. The developing countries are particularly facing the dual burden on under-nutrition and obesity. This is associated with appearance and clustering of cardiometabolic abnormalities at an early age with development of chronic complications early and possible decrease in life span of these children and adolescents. In adults this clustering has been termed as 'metabolic syndrome' with definitions that can be used universally...
December 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29217212/ovarian-morphology-by-transabdominal-ultrasound-correlates-with-reproductive-and-metabolic-disturbance-in-adolescents-with-pcos
#20
Beth W Rackow, Heidi Vanden Brink, Lynwood Hammers, Clare A Flannery, Marla E Lujan, Tania S Burgert
PURPOSE: To determine whether ovarian morphology imaged using transabdominal ultrasonography reflects clinical and metabolic features in adolescents with polycystic ovary syndrome (PCOS). METHODS: A retrospective pilot study was conducted in 33 adolescents (12-18 years) with PCOS as defined by hyperandrogenism and irregular cycles. Adolescents underwent the following assessments at a random time during the menstrual cycle: transabdominal ultrasonography, physical examination (height, weight, and systolic and diastolic blood pressure), fasting hormonal tests (free, percent free, and total testosterone, androstenedione, follicle stimulating hormone, luteinizing hormone), and metabolic tests (including an oral glucose tolerance test, fasting and 2-hour insulin and glucose, homeostatic model assessment of insulin resistance, and whole-body insulin sensitivity index)...
December 5, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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