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metabolic syndrome adolescents

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https://www.readbyqxmd.com/read/29117624/the-role-of-lipids-in-the-pathogenesis-of-metabolic-syndrome-in-adolescents
#1
Shahnaz Taghizadeh, Mohammad Alizadeh
The increasing prevalence of childhood obesity is a driving force behind the increase in adolescent's metabolic syndrome (MetS). Although there is no clear consensus about the pediatric definition for MetS, this syndrome is becoming very common among adolescents. It is characterized by insulin resistance (IR), dyslipidemia, abdominal obesity and hypertension, and is associated with a high risk of type 2 diabetes mellitus and CVD in adulthood. Due to the increasing prevalence of obesity, there is strong incentive to reduce the impact of the adverse health effects associated with MetS...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29114265/dehydroepiandrosterone-sulfate-insulin-resistance-and-ovarian-volume-estimation-in-patients-with-polycystic-ovarian-syndrome
#2
Chrysi Christodoulaki, Eftihios Trakakis, Vasilios Pergialiotis, Periklis Panagopoulos, Charalampos Chrelias, Dimitrios Kassanos, Dimos Sioutis, Nikolaos Papantoniou, Dimitrios Xirofotos
Objective: To investigate the potential association of DHEA-S with metabolic and hormonal alterations and with disorders of ovarian morphology. Materials and methods: The present study was based on women with PCOS that attended the Gynaecological Endocrinology - Paediatric and Adolescence Endocrinology Department of our clinic. Overall, 321 patients who met the Rotterdam ESHRE/ ASRM - Sponsored criteria for the definition of PCOS were included. Women's personal medical history was recorded, anthropometric parameters were assessed and blood was drawn for analysis of metabolic and hormonal parameters...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29101669/25oh-vitamin-d-levels-in-pediatric-patients-affected-by-prader-willi-syndrome
#3
D Fintini, S Pedicelli, S Bocchini, C Bizzarri, G Grugni, M Cappa, A Crinò
PURPOSE: Obesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader-Willi syndrome (PWS), a genetic form of obesity, is not yet available. OBJECTIVE: To analyze the 25OHD values in pediatric PWS subjects in comparison with a control group (CNT), highlighting the possible correlations with IR, BMD, body composition, pubertal stage, and GH therapy (GHT)...
November 3, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29100483/breastfeeding-and-risk-of-metabolic-syndrome-in-children-and-adolescents-a-systematic-review
#4
Lauren Wisnieski, Jean Kerver, Claudia Holzman, David Todem, Claire Margerison-Zilko
BACKGROUND: The beneficial effect of breastfeeding on individual components of the metabolic syndrome in children and adolescents has been reported, but it is unknown if there is an association between being breastfed and metabolic syndrome as a whole. Research aim: This systematic review was performed to assess quality and strength of evidence for the association between being breastfed and the development of metabolic syndrome in children and adolescents. METHODS: Articles were obtained from searches using PubMed and Embase databases, as well as from secondary searches through reference lists...
November 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29099111/subtle-metabolic-alterations-in-adolescents-with-obesity-and-polycystic-ovarian-syndrome
#5
Víctor Saúl Vital-Reyes, Mardia Guadalupe Lopez-Alarcón, Patricia Inda-Icaza, Concepción Márquez-Maldonado
Objective: To evaluate the frequency of some subtle metabolic alterations in a group of adolescents with obesity and polycystic ovary syndrome (PCOS). Materials and Methods: A cross-sectional, comparative study was conducted in a group of adolescents with obesity, and characterized as with or without PCOS according with the Rotterdam Consensus. Medical history, anthropometry, gynecologic pelvic ultrasound (to evaluate ovarian volumes, number of antral follicles and endometrial width), as well as serum glucose, insulin, lipoproteins, interleukin-6, tumor necrosis factor alpha, total testosterone, dehydroepiandrosterone, sexual hormones binding globulin, leptin, adiponectin and insulin-like growth factor 1, the free-androgen index, free and available testosterone, and homeostatic model assessment index were calculated...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29095002/-physical-fitness-and-insulin-sensitivity-in-a-group-of-obese-children-from-8-to-13-years-of-age-by-puberal-state
#6
Fabián Vasquez, Erik Diaz, Lydia Lera, Jorge Meza, Katherine Curi, Jorge Torres, Raquel Burrows
INTRODUCTION: Insulin resistance is the most common metabolic disorder associated with obesity and highest cardiometabolic risk in children. If the inadequate physical condition is added, they have a high risk of developing cardiometabolic complications at an early age. OBJECTIVE: To evaluate physical fitness and insulin sensitivity in obese school children of 8-13 years of age from three public schools in the Metropolitan Region of Santiago. METHODS: the study was carried out in 61 obese school children (25 Tanner I-II y 36 Tanner III-V)...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29094277/association-of-anthropometric-indices-with-continuous-metabolic-syndrome-in-children-and-adolescents-the-caspian-v-study
#7
Hanieh-Sadat Ejtahed, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Pooneh Angoorani, Shirin Hasani-Ranjbar, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Shaghayegh Beshtar, Tahereh Aminaee, Ramin Heshmat, Roya Kelishadi
PURPOSE: This study aims to examine the association of anthropometric indices with continuous metabolic syndrome (cMetS) among Iranian children and adolescents. METHODS: This multicentric study was conducted on 14138 students aged 7-18 years, who participated in a national surveillance program. Fasting blood sample was obtained from a subsample of 3843 randomly selected students. Physical examination including the measurement of anthropometric indices and blood pressure was conducted; fasting blood glucose and lipid profile were measured; and cMetS score was computed...
November 1, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29093301/adipokines-are-associated-with-hypertension-in-metabolically-healthy-obese-mho-children-and-adolescents-a-prospective-population-based-cohort-study
#8
Wenqing Ding, Hong Cheng, Fangfang Chen, Yinkun Yan, Meixian Zhang, Xiaoyuan Zhao, Dongqing Hou, Jie Mi
BACKGROUND: The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. The aim of the study was to prospectively investigate the potential role of the adipokines in the association between the MHO phenotype and hypertension in children and adolescents. METHODS: A total of 1184 participants at baseline were recruited from a cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study...
October 25, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29082896/optimal-cut-off-points-of-fasting-and-post-glucose-stimulus-surrogates-of-insulin-resistance-as-predictors-of-metabolic-syndrome-in-adolescents-according-to-several-definitions
#9
Mónica Ivette Piña-Agüero, Aranza Zaldivar-Delgado, Alejandra Salas-Fernández, Azucena Martínez-Basila, Mariela Bernabe-García, Jorge Maldonado-Hernández
OBJECTIVE: The aim of this study was to determine optimal cut-off points of fasting and post-glucose stimulus surrogates of insulin resistance to predict metabolic syndrome in adolescents according to several definitions. METHODS: 155 adolescents living in Mexico City were enrolled during 2011 and 2012. Waist circumference and blood pressure were recorded. Subjects received an oral glucose load of 1.75g per kg up to a maximum dose of 75g. Blood samples were drawn at baseline and 120 minutes...
October 30, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29068599/body-composition-in-13-year-old-adolescents-with-abdominal-obesity-depending-on-the-bmi-value
#10
Zuzanna S Goluch-Koniuszy, Magdalena Kuchlewska
BACKGROUND: Excessive adipocyte growth during the pubertal transition predisposes to the development and persistence of obesity in adulthood. Visceral accumulation of body fat is particularly disadvantageous when it is correlated with insulin resistance, secondary hyperinsulinaemia, dysglicaemia, and atherogenic dyslipidemia. OBJECTIVES: The aim of this study was to conduct a nutritional status assessment and body composition analysis in 13-year-old adolescents of both genders with visceral fat accumulation (WC ≥ 90th percentile) and different BMI values...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29049309/validation-of-surrogate-markers-for-metabolic-syndrome-and-cardiometabolic-risk-factor-clustering-in-children-and-adolescents-a-nationwide-population-based-study
#11
Ji-Young Seo, Jae Hyun Kim
Prevalence of metabolic syndrome (MetS) in children is increasing and identifying the risk factors for MetS during childhood is an important first step to prevent chronic diseases later in life. The aim of the present study was to evaluate the prevalence of MetS and cardiometabolic risk factor (CMRF) clustering among Korean children and adolescents and to validate the associated anthropometric and laboratory surrogate markers. We used data from the 2011-2014 Korean National Health and Nutrition Examination Survey...
2017: PloS One
https://www.readbyqxmd.com/read/29037330/waist-circumference-shows-the-highest-predictive-value-for-metabolic-syndrome-and-waist-to-hip-ratio-for-its-components-in-spanish-adolescents
#12
Javier S Perona, Jacqueline Schmidt-RioValle, Blanca Rueda-Medina, María Correa-Rodríguez, Emilio González-Jiménez
Both waist circumference (WC) and waist-to-hip ratio (WHR) have been proposed as predictors of metabolic syndrome (MetS) in adolescents, but no consensus has been reached to date. This study hypothesizes that WC provides a greater predictive value for MetS in Spanish adolescents than WHR. A cross-sectional study was performed on 1001 adolescents (13.2 ± 1.2 years) randomly recruited from schools in southeast Spain. Anthropometric measures were correlated with the components of MetS (triglycerides, glucose, blood pressure, and high-density lipoprotein cholesterol) as well as inflammation markers (interleukin-6 and tumor necrosis factor-alpha , C-reactive protein, and ceruloplasmin)...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29023232/early-onset-obesity-and-risk-of-metabolic-syndrome-among-chilean-adolescents
#13
Lorena Sonia Pacheco, Estela Blanco, Raquel Burrows, Marcela Reyes, Betsy Lozoff, Sheila Gahagan
INTRODUCTION: Obesity and metabolic syndrome (MetS) indicators have increased globally among the pediatric population. MetS indicators in the young elevate their risk of cardiovascular disease and metabolic disorders later in life. This study examined early onset obesity as a risk factor for MetS risk in adolescence. METHODS: A cohort of Chilean participants (N = 673) followed from infancy was assessed at age 5 years and in adolescence (mean age, 16.8 y). Adiposity was measured at both time points; blood pressure and fasting blood samples were assessed in adolescence only...
October 12, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29020125/construction-and-validation-of-educational-materials-for-the-prevention-of-metabolic-syndrome-in-adolescents
#14
Ionara Holanda de Moura, Antônia Fabiana Rodrigues da Silva, Aparecida do Espírito Santo de Holanda Rocha, Luisa Helena de Oliveira Lima, Thereza Maria Magalhães Moreira, Ana Roberta Vilarouca da Silva
OBJECTIVE: To develop and validate an educational technology focused on prevention of metabolic syndrome among adolescents. METHODS: This was methodological research. Using an integrative review, the available publications on the subject were analyzed. Then, this knowledge was used to describe the theoretical content and, with the help of a graphic designer, the art and layout of the pages were developed. In the third phase, the booklet was evaluated and validated by 21 specialists and 39 adolescents...
October 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29020116/leptin-adiponectin-imbalance-as-a-marker-of-metabolic-syndrome-among-chinese-children-and-adolescents-the-bcams-study
#15
Ge Li, Linxin Xu, Yanglu Zhao, Lujiao Li, Junling Fu, Qian Zhang, Naishi Li, Xinhua Xiao, Changhong Li, Jie Mi, Shan Gao, Ming Li
PURPOSE: Leptin and adiponectin have opposite effects on subclinical inflammation and insulin resistance, both involved in the development of metabolic syndrome (MS). We aimed to investigate whether leptin/adiponectin ratio (L/A), as a marker of these two adipokines imbalance, may improve diagnosis of MS in children and adolescents, and determined its cut-off value in the diagnosis of MS. METHODS: A total of 3,428 subjects aged 6-18 years were selected from Beijing Child and Adolescent Metabolic Syndrome study...
2017: PloS One
https://www.readbyqxmd.com/read/28988228/the-relationship-between-non-alcoholic-fatty-liver-disease-and-small-intestinal-bacterial-overgrowth-among-overweight-and-obese-children-and-adolescents
#16
Oana Belei, Laura Olariu, Andreea Dobrescu, Tamara Marcovici, Otilia Marginean
BACKGROUND: The increasing rate of obesity and overweight among children has highlighted nonalcoholic fatty liver disease (NAFLD) as the most common cause of chronic pediatric liver diseases. There are many publications supporting the idea that gut microbiota is altered in NAFLD. The aim of this study was to evaluate the prevalence of NAFLD among overweight and obese children with and without small intestinal bacterial overgrowth (SIBO) compared to a control group and to assess if intestinal dysbiosis represents a risk factor for NAFLD...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28971467/bioimpedance-measurements-in-adolescents-with-polycystic-ovary-syndrome-a-pilot-study
#17
Styliani A Geronikolou, Flora Bacopoulou, Dennis Cokkinos
Limited data are available on the body composition of adolescent women with polycystic ovary syndrome (PCOS). The aim of this study was to examine differences in body composition indices of metabolism, homeostasis and inflammation, between Greek adolescent females suffering from PCOS and age- and body mass index (BMI)-matched non-PCOS controls. Thirteen PCOS patients and nine non-PCOS controls, aged 13-24 years participated in this cross-sectional study. Study participants underwent assessment by a novel dual frequency bioimpedance device (BIA-ACC)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28969353/the-link-between-the-immune-system-environment-and-psychosis
#18
Rajiv Radhakrishnan, Muzaffer Kaser, Sinan Guloksuz
The last decade has witnessed a burgeoning interest in studies exploring the link between psychosis spectrum disorders (PSD) and altered immune function. While epidemiological and clinical studies point to evidence for increased peripheral inflammatory markers in PSD, it is not clear whether peripheral inflammation correlates with central inflammation in the brain. Furthermore, these studies are confounded by multiple methodological and disorder-related factors such as antipsychotic medications, smoking, obesity, and metabolic syndrome, all of which independently contribute to altered inflammation...
July 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28951977/polycystic-ovary-syndrome-throughout-a-woman-s-life
#19
REVIEW
José Bellver, Luis Rodríguez-Tabernero, Ana Robles, Elkin Muñoz, Francisca Martínez, José Landeras, Juan García-Velasco, Juan Fontes, Mónica Álvarez, Claudio Álvarez, Belén Acevedo
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age...
September 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28948819/specific-metabolic-characteristics-of-women-with-former-gestational-diabetes-the-importance-of-adipose-tissue
#20
D Vejrazkova, M Vankova, P Lukasova, J Vcelak, V Cirmanova, M Haluzik, B Bendlova
Women with a positive history of gestational diabetes mellitus (GDM) face a higher risk of developing type 2 diabetes mellitus (T2DM) and metabolic syndrome later in life. The higher risk of these metabolic complications is closely associated with adipose tissue. In this review, the importance of adipose tissue is discussed in relation to GDM, focusing on both the quantity of fat deposits and the metabolic activity of adipose tissue in particular periods of life: neonatal age, childhood, adolescence, and pregnancy followed by nursing...
September 26, 2017: Physiological Research
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