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https://www.readbyqxmd.com/read/29668140/-standardization-of-a-multiplex-real-time-pcr-test-for-the-identification-of-angiostrongylus-cantonensis-a-costaricensis-and-a-vasorum
#1
Rubén E Varela-M, Jinney Stefany Arias, Luz Elena Velásquez
INTRODUCTION: Angiostrongyliasis is a disease caused by Angiostrongylus nematodes that is present worldwide. The infections with the highest impact on human and animal health are caused by A. cantonensis, A. costaricensis, and A. vasorum. Clinical forms of the disease in humans are eosinophilic meningitis and abdominal angiostrongyliasis, while the most common effect on dogs are cardiopulmonary damages. It is deemed as an emerging disease as the result of the global dissemination of the African snail Lissachatina fulica, an intermediary host of these parasites...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668129/-tuberculosis-in-the-era-of-anti-tnf-alpha-therapy-why-does-the-risk-still-exist
#2
John-Leonardo Torres-Castiblanco, Jorge Alberto Carrillo, Daniel Hincapié-Urrego, Adriana Rojas-Villarraga
Rheumatoid arthritis is an autoimmune systemic disease characterized mainly by inflammatory compromise of diarthrodial joints. Multiple drug therapies have been developed to control the activity of rheumatoid arthritis, among them, the first line of disease-modifying antirheumatic drugs (DMARD), and novel drug therapies such as the anti-TNF alpha therapy, with satisfactory clinical outcomes.Despite this positive fact, the use of this therapy implies the risk of producing negative effects due to its mechanism of action, which has been associated with multiple infections, especially tuberculosis, making it necessary to use screen tests before resorting to this kind of drugs...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668075/a-comparison-of-debate-and-role-play-in-enhancing-critical-thinking-and-communication-skills-of-medical-students-during-problem-based-learning
#3
Rabia Latif, Sadaf Mumtaz, Rafia Mumtaz, Aamir Hussain
Debate and role play for learning critical thinking and communication skills are being increasingly used in various undergraduate medical schools worldwide. We aim to compare students' views about effectiveness of two teaching strategies; debate and role play to exercise critical thinking and communication skills during problem-based learning (PBL). This is a comparative, cross-sectional, and questionnaire-based study. Our subjects were second year undergraduate female medical students enrolled in Imam Abdulrahman Bin Faisal University (IAU), College of Medicine from September 2014-2016, divided into 10 small PBL groups (10-13 students/group/year)...
April 18, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29668039/medical-marijuana-use-in-older-adults
#4
Joshua Briscoe, David Casarett
Symptom management in older adults, including pain and distressing non-pain symptoms, can be challenging. Medications can cause side effects that worsen quality of life or create other symptoms, and polypharmacy itself can be detrimental in older adults. Cannabinoids may offer a way of managing selected symptoms with fewer side effects. Medical marijuana is an important area of study for older adults because of the side effects of other medications. It is also important for Baby Boomers, who are likely to have more experience with marijuana than older adults of previous generations...
April 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29668038/photodynamic-therapy-induces-antifibrotic-alterations-in-primary-human-vocal-fold-fibroblasts
#5
Chi Zhang, Jiajia Wang, Adriana Chou, Ting Gong, Erin E Devine, Jack J Jiang
OBJECTIVES/HYPOTHESIS: Photodynamic therapy (PDT) is a promising treatment modality for laryngeal dysplasia, early-stage carcinoma, and papilloma, and was reported to have the ability to preserve laryngeal function and voice quality without clinical fibrotic response. We aimed to investigate the mechanism behind the antifibrotic effects of PDT on primary human vocal fold fibroblasts (VFFs) in vitro. STUDY DESIGN: In vitro analysis from one human donor. METHODS: Cell viability of VFFs in response to varying doses of PDT was investigated by the Cell Counting Kit-8 method...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668037/treatment-of-chronic-neurogenic-cough-with-in-office-superior-laryngeal-nerve-block
#6
C Blake Simpson, Kathleen M Tibbetts, Michael J Loochtan, Laura M Dominguez
OBJECTIVES: Neurogenic cough is believed to result from a sensory neuropathy involving the internal branch of the superior laryngeal nerve (SLN). We present our outcomes for the treatment of neurogenic cough with localized blockade of the internal branch of the SLN. METHODS: A retrospective chart review of patients who underwent in-office percutaneous SLN block for treatment of neurogenic cough between 2015 and 2017 was conducted. Patient demographics, indications for injection, and response to treatment were recorded and analyzed...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#7
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29667890/novel-quality-indicators-for-radiologists-interpreting-abdominopelvic-ct-images-risk-adjusted-outcomes-among-emergency-department-patients-with-right-lower-quadrant-pain
#8
Matthew S Davenport, Shokoufeh Khalatbari, James H Ellis, Richard H Cohan, Suzanne T Chong, Keith E Kocher
OBJECTIVE: The purpose of this study was to determine whether individual radiologists are predictive of important relevant health outcomes among emergency department (ED) patients undergoing abdominopelvic CT for right lower quadrant pain. MATERIALS AND METHODS: This single-institution retrospective cohort study included 2169 patients undergoing abdominopelvic CT for right lower quadrant pain in the ED from February 1, 2012, through August 31, 2016. CT examinations were interpreted by 15 radiologists (four emergency, 11 abdominal) who each reported on more than 70 CT examinations in the cohort...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667886/performance-comparison-between-18-f-fdg-pet-ct-plus-brain-mri-and-conventional-staging-plus-brain-mri-in-staging-of-small-cell-lung-carcinoma
#9
Yuji Kishida, Shinichiro Seki, Takeshi Yoshikawa, Tomoo Itoh, Yoshimasa Maniwa, Yoshihiro Nishimura, Yoshiharu Ohno
OBJECTIVE: The purpose of this study was to prospectively compare the capabilities of integrated FDG PET/CT and conventional staging for identification of TNM factors, evaluation of the TNM and Veterans Administration Lung Study Group (VALSG) stages, and selection of patients with stage I small cell lung carcinoma (SCLC). SUBJECTS AND METHODS: Fifty-nine patients (mean age, 69.6 ± 7.8 [SD] years; range, 40-84 years) with pathologically diagnosed SCLC underwent integrated 18 F-FDG PET/CT and conventional staging with enhanced brain MRI...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667856/low-oxygen-environment-facilitates-embryo-availability-for-older-ovarian-responders-pors
#10
Mingzhao Li, Zhibin Li, Juanzi Shi
We aimed to investigate the different effects of low oxygen (5% O2 ) and atmospheric oxygen (20% O2 ) on in vitro fertilization for older poor ovarian responders (PORs). We selected 1080 older PORs who met two criteria: (i) advanced maternal age (≥40) and (ii) an abnormal ovarian reserve test. All the patients used the ultra-short term protocols with GnRH agonist and recombinant FSH for controlled ovarian hyperstimulation (COH). About 506 cycles were performed in the incubators with 5% O2 and 574 cycles were performed in the incubators with 20% O2 ...
April 18, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29667842/the-role-of-pcsk9-inhibitors-in-the-treatment-of-hypercholesterolemia
#11
Roshni S Patel, Emily M Scopelliti, Oludamilola Olugbile
OBJECTIVE: To evaluate the efficacy, safety, and cost-effectiveness of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors and describe its place in therapy for the treatment of hypercholesterolemia. DATA SOURCES: A search of MEDLINE, CINAHL, and Clinicaltrials.gov was performed from January 2012 to March 2018 to identify literature pertaining to PCSK9 inhibitors using pre-specified search terms. Additional references were identified from citations of the literature...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29667799/shrink-that-frown-botulinum-toxin-therapy-is-lifting-the-face-of-psychiatry
#12
M Axel Wollmer, Insa Neumann, Michelle Magid, Tillmann H Kruger
Treating glabellar frown lines with injections of botulinum toxin is the most frequently applied procedure in aesthetic medicine. In addition to its cosmetic effect, botulinum toxin may also positively modulate mood and affect, which may contribute to its popularity. A series of clinical studies has shown that this modulation can be used in the treatment of major depression. After a single glabellar treatment with botulinum toxin, patients suffering from unipolar depression experienced a quick, strong and sustained improvement in the symptoms of depression...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667792/habit-reversal-training-for-body-focused-repetitive-behaviors-a-practical-guide-for-the-dermatologist
#13
Amber B Dunbar, Michelle Magid, Jason S Reichenberg
Habit reversal training (HRT) is a clinically effective treatment for body-focused repetitive disorders (BFRDs) such as trichotillomania, onychophagia, and dermatillomania. Despite many dermatology providers knowing the term HRT, very few understand what HRT is and how it actually works. In this article, we give a detailed explanation of HRT and walk the reader through a six-session HRT protocol. We will briefly discuss adjunct interventions for BFRDs, including pharmacological approaches. We aim to make dermatologists more comfortable in offering basic HRT within their clinics and to close the gap that currently exists between patients who are HRT candidates and those who receive HRT treatment...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667789/updates-and-controversies-in-the-management-of-acute-optic-neuritis
#14
Ethan Meltzer, Sashank Prasad
Optic neuritis remains a common diagnosis with controversial management. Although typical optic neuritis is often associated with "good" recovery of visual acuity, patients are often left with persistent impairments of contrast sensitivity, color vision, and visual field. These permanent visual deficits correlate with structural injury to the anterior visual pathway and are closely linked to visual quality of life. High dose corticosteroids are commonly used for patients with acute optic neuritis...
April 18, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29667772/tead4-exerts-pro-metastatic-effects-and-is-negatively-regulated-by-mir6839-3p-in-lung-adenocarcinoma-progression
#15
Qun Zhang, Hang Fan, Qian Zou, Hongda Liu, Bing Wan, Suhua Zhu, Yangbo Hu, Huijuan Li, ChenXi Zhang, Li Zhou, Qingqing Zhu, Kunhong Xiao, Jianya Zhang, Ping Zhan, Tangfeng Lv, Yong Song
Several studies have shown the tumorigenesis role of transcriptional enhancer associate domain (TEAD) proteins; here, we initially explored expression, function and signalling mechanisms of TEAD4 in lung adenocarcinoma (LAD). Both the mRNA and protein levels of TEAD4 were increased in LAD tissues than those in adjacent nontumourous tissues. Besides, database search indicated a poorer clinical outcome in LAD patients with higher TEAD4 expression, revealing its potential tumour-promoting role. Therefore, we conducted cellular experiments to further investigate its effect on tumour phenotypes...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667769/targeting-the-phosphatidylinositol-3-kinase-akt-mechanistic-target-of-rapamycin-signaling-pathway-in-b-lineage-acute-lymphoblastic-leukemia-an-update
#16
REVIEW
Carolina Simioni, Alberto M Martelli, Giorgio Zauli, Marco Vitale, James A McCubrey, Silvano Capitani, Luca M Neri
Despite considerable progress in treatment protocols, B-lineage acute lymphoblastic leukemia (B-ALL) displays a poor prognosis in about 15-20% of pediatric cases and about 60% of adult patients. In addition, life-long irreversible late effects from chemo- and radiation therapy, including secondary malignancies, are a growing problem for leukemia survivors. Targeted therapy holds promising perspectives for cancer treatment as it may be more effective and have fewer side effects than conventional therapies. The phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway is a key regulatory cascade which controls proliferation, survival and drug-resistance of cancer cells, and it is frequently upregulated in the different subtypes of B-ALL, where it plays important roles in the pathophysiology, maintenance and progression of the disease...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667739/maternal-depressive-symptoms-during-and-after-pregnancy-and-child-developmental-milestones
#17
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lipsanen, Jari Lahti, Kati Heinonen, Rebecca M Reynolds, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Anu-Katriina Pesonen, Pia M Villa, Katri Räikkönen
BACKGROUND: Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, and additive influences remain unclear. METHODS: A total of 2,231 mothers of the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly up to 14 times during pregnancy and twice up to 12 months after pregnancy...
April 18, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29667729/hla-dqb1-03-genotype-and-perioperative-blood-transfusion-are-not-conducive-to-the-prognosis-of-patients-with-gastric-cancer
#18
Shen-Kang Zhou, Lei-Lei Yang, Rui Chen, Yong Lu, Yong-Hua Zheng
BACKGROUND: Gastric cancer (GC) is a disease associated with a higher incidence and mortality, and some host genetic polymorphisms have been reported as potential factors contributing to the development of GC. In view of this, the study was conducted to investigate the effects of HLA-DQB1 gene polymorphisms and perioperative blood transfusion on prognosis of patients with gastric cancer (GC). METHODS: A total of 142 patients with GC (case group) and 150 healthy controls (control group) were enrolled...
April 18, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#19
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29667584/pharmacist-interventions-during-patient-rounds-in-two-intensive-care-units-clinical-and-financial-impact
#20
B E Bosma, P M L A van den Bemt, P H G J Melief, J van Bommel, S S Tan, N G M Hunfeld
INTRODUCTION: The risk of prescribing errors and related adverse drug events (ADE) on the intensive care unit (ICU) is high. Based on studies carried out in North America or the UK, a clinical pharmacy service can reduce ADEs and lower overall costs. This study looks into the clinical and financial impact of interventions made by pharmacists during patient rounds in two ICU settings in the Netherlands. MATERIALS AND METHODS: A quality improvement study was performed in a general teaching hospital (GTH) and a university hospital (UH) in the Netherlands...
April 2018: Netherlands Journal of Medicine
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