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Notch pathway

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https://www.readbyqxmd.com/read/29677185/patterning-mechanisms-diversify-neuroepithelial-domains-in-the-drosophila-optic-placode
#1
Abhishek Kumar Mishra, F Javier Bernardo-Garcia, Cornelia Fritsch, Tim-Henning Humberg, Boris Egger, Simon G Sprecher
The central nervous system develops from monolayered neuroepithelial sheets. In a first step patterning mechanisms subdivide the seemingly uniform epithelia into domains allowing an increase of neuronal diversity in a tightly controlled spatial and temporal manner. In Drosophila, neuroepithelial patterning of the embryonic optic placode gives rise to the larval eye primordium, consisting of two photoreceptor (PR) precursor types (primary and secondary), as well as the optic lobe primordium, which during larval and pupal stages develops into the prominent optic ganglia...
April 20, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29674611/inhibition-of-dll4-notch1-pathway-promotes-angiogenesis-of-masquelet-s-induced-membrane-in-rats
#2
Qian Tang, Haimin Jin, Minji Tong, Gang Zheng, Zhongjie Xie, Shangkun Tang, Jialei Jin, Ping Shang, Huazi Xu, Liyan Shen, Yu Zhang, Haixiao Liu
The Masquelet's induced membrane technique for repairing bone defects has been demonstrated to be a promising treatment strategy. Previous studies have shown that the vessel density of induced membrane is decreased in the late stage of membrane formation, which consequently disrupts the bone healing process. However, relatively little is known about certain mechanisms of vessel degeneration in the induced membrane tissue and whether promotion of angiogenesis in induced membranes can improve bone regeneration...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29668883/deletion-of-delta-like-1-homologue-accelerates-fibroblast-myofibroblast-differentiation-and-induces-myocardial-fibrosis
#3
Patricia Rodriguez, Yassine Sassi, Luca Troncone, Ludovic Benard, Kiyotake Ishikawa, Ronald E Gordon, Santiago Lamas, Jorge Laborda, Roger J Hajjar, Djamel Lebeche
Aims: Myocardial fibrosis is associated with profound changes in ventricular architecture and geometry, resulting in diminished cardiac function. There is currently no information on the role of the delta-like homologue 1 (Dlk1) in the regulation of the fibrotic response. Here, we investigated whether Dlk1 is involved in cardiac fibroblast-to-myofibroblast differentiation and regulates myocardial fibrosis and explored the molecular mechanism underpinning its effects in this process. Methods and results: Using Dlk1-knockout mice and adenoviral gene delivery, we demonstrate that overexpression of Dlk1 in cardio-fibroblasts resulted in inhibition of fibroblast proliferation and differentiation into myofibroblasts...
April 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29666782/new-perspectives-on-diagnosis-and-therapy-of-malignant-pleural-mesothelioma
#4
REVIEW
Marika Rossini, Paola Rizzo, Ilaria Bononi, Anthony Clementz, Roberto Ferrari, Fernanda Martini, Mauro G Tognon
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons per million of the general population, leading to thousands of deaths every year worldwide. To date, the MPM is mostly associated with occupational asbestos exposure. Asbestos represents the predominant etiological factor, with approximately 70% of cases of MPM with well-documented occupational exposure to asbestos, with the exposure time, on average greater than 40 years...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29666622/chemotactic-cues-for-notch1-dependent-leukemia
#5
REVIEW
Erich Piovan, Valeria Tosello, Alberto Amadori, Paola Zanovello
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems. Aberrant activity of this signaling pathway is linked to the initiation and progression of several hematological malignancies, exemplified by T-cell acute lymphoblastic leukemia (T-ALL). Interestingly, frequent non-mutational activation of NOTCH1 signaling has recently been demonstrated in B-cell chronic lymphocytic leukemia (B-CLL), significantly extending the pathogenic significance of this pathway in B-CLL...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29665935/-prokaryotic-expression-and-purification-of-the-notch-ligand-and-its-effect-on-hematopoiesis-after-carbon-tetrachloride-damage
#6
Juan-Juan Chen, Si-Yong Huang, Peng-Fei Ma, Bi-Jia Wu, Si-Lang Zhou, Yong-Xing Zhao, Jun-Mei Gong, Ying-Min Liang
OBJECTIVE: To express and purify the mouse endothelial cell-targeted recombinant Notch ligand protein mD1R, and to investigate its effect on hematopoiesis after carbon tetrachloride damage. METHODS: PCR was performed to clone and construct the expression vector pET22b(+)-mD1R. The mD1R successfully transformed into E. coli was induced by IPTG, and purified with Ni2+ -beads affinity chromatography. The target protein was detected by SDS-PAGE. The fluorescence-activated cell sorting analysis (FACS), cell adhesion test, immunofluorescence staining and quantitative real-time PCR were employed to detect the endothelial cell-targeted and Notch signaling-activated biological characteristics of mD1R...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665790/the-oncogenic-effects-of-hes1-on-salivary-adenoid-cystic-carcinoma-cell-growth-and-metastasis
#7
Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu
BACKGROUND: Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS: Comparative transcriptome analyses by RNA-Sequencing (RNA-Seq) were employed to reveal NOTCH1 downstream gene in SACC cells. Immunohistochemical staining was used to detect the expression of HES1 in clinical samples...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29664186/notch-signaling-regulates-lgr5-olfactory-epithelium-progenitor-stem-cell-turnover-and-mediates-recovery-of-lesioned-olfactory-epithelium-in-mouse-model
#8
Qi Dai, Chen Duan, Wenwen Ren, Fangqi Li, Qian Zheng, Li Wang, Wenyan Li, Xiaoling Lu, Wenli Ni, Yanping Zhang, Yan Chen, Tieqiao Wen, Yiqun Yu, Hongmeng Yu
The Notch signaling pathway regulates stem cell proliferation and differentiation in multiple tissues and organs, and is required for tissue maintenance. However, the role of Notch in regulation of olfactory epithelium (OE) progenitor/stem cells to maintain tissue function is still not clear. A recent study reported that leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is expressed in globose basal cells (GBCs) localized in OE. Through lineage tracing in vivo, we found that Lgr5+ cells act as progenitor/stem cells in OE...
April 17, 2018: Stem Cells
https://www.readbyqxmd.com/read/29663635/di-2-ethylhexyl-phthalate-dehp-induced-testicular-toxicity-through-nrf2-mediated-notch1-signaling-pathway-in-sprague-dawley-rats
#9
Xiangliang Tang, Shengde Wu, Lianju Shen, Yi Wei, Xining Cao, Yangcai Wang, Chunlan Long, Yue Zhou, Dian Li, Fangyuan Huang, Bo Liu, Guanghui Wei
Di-(2-ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor widely used in China that is harmful to the male reproductive system. Many studies have shown that DEHP causes testicular toxicity through oxidative stress, but the specific mechanism is unknown. Because the Notch pathway is a key mechanism for regulating cell growth and proliferation, we investigated whether Notch is involved in DEHP-induced testicular toxicity and whether vitamins E and C could rescue testicular impairment in Sprague-Dawley (SD) rats...
April 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29662441/characterization-of-hair-cell-like-cells-converted-from-supporting-cells-after-notch-inhibition-in-cultures-of-the-organ-of-corti-from-neonatal-gerbils
#10
Yi Li, Shuping Jia, Huizhan Liu, Tomoko Tateya, Weiwei Guo, Shiming Yang, Kirk W Beisel, David Z Z He
The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells as a result of aging or exposure to noise and ototoxic drugs is the major cause of noncongenital hearing and balance deficits. In the ear of non-mammals, lost hair cells can spontaneously be replaced by production of new hair cells from conversion of supporting cells. Although supporting cells in adult mammals have lost that capability, neonatal supporting cells are able to convert to hair cells after inhibition of Notch signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29662198/the-mir-106b-25-cluster-mediates-breast-tumor-initiation-through-activation-of-notch1-via-direct-repression-of-nedd4l
#11
A L Guarnieri, C G Towers, D J Drasin, M U J Oliphant, Z Andrysik, T J Hotz, R L Vartuli, E S Linklater, A Pandey, S Khanal, J M Espinosa, H L Ford
Tumor-initiating cells (TIC) represent a subset of tumor cells with increased self-renewal capability. TICs display resistance to frontline cancer treatment and retain the ability to repopulate a tumor after therapy, leading to cancer relapse. NOTCH signaling has been identified as an important driver of the TIC population, yet mechanisms governing regulation of this pathway in cancer remain to be fully elucidated. Here we identify a novel mechanism of NOTCH regulation and TIC induction in breast cancer via the miR-106b-25 miRNA cluster...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29658611/effects-of-nicotine-on-the-metabolism-and-gene-expression-profile-of-sprague%C3%A2-dawley-rat-primary-osteoblasts
#12
Dan Liang, Ke-Jing Wang, Zhi-Qun Tang, Run-He Liu, Fulei Zeng, Miao-Ying Cheng, Qi-Si Lian, Hong-Kun Wu
Smoking is a risk factor associated with bone and oral diseases, particularly periodontitis. Nicotine, the major toxic component of tobacco, is able to affect the quality and quantity of bone. Osteoblasts serve an important role in bone formation. Thus far, the effects of nicotine on metabolism‑associated gene and protein expression in osteoblasts have been controversial and the mechanisms remain unclear. The present study assessed alterations in osteogenic activity by performing a Cell Counting kit‑8 assay to investigate proliferation, Annexin V‑fluorescein isothiocyanate/propidium iodide staining to investigate apoptosis, alizarin red staining to investigate the formation of mineralized nodules, reverse transcription‑quantitative polymerase chain reaction and western blotting to investigate the mRNA and protein levels of collagen I, alkaline phosphatase, bone osteocalcin, bone sialoprotein and osteopontin; and mRNA microarray expression analysis, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analysis to investigate the whole genome expression profile of Sprague‑Dawley (SD) rat primary osteoblasts following treatment with different concentrations of nicotine...
April 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29658608/ipsc%C3%A2-msc-inhibition-assessment-in-raw-264-7-cells-following-oxygen-and-glucose-deprivation-reveals-a-distinct-function-for-cardiopulmonary-resuscitation
#13
Yi Yu, Dongping Wang, Hui Li, Yujie Liu, Zhao Xiang, Junlin Wu, Xiaoli Jing
Hypoxia is a serious stress state. The nervous system is less tolerant to hypoxia, and cell death due to hypoxia is irreversible. With the incidence of cardiovascular disease gradually increasing, the sudden cardiac death rate is additionally increasing. Although cardiopulmonary resuscitation (CPR) is an important development, recovery is frequently poor. In a successful recovery population, ~40% of the population was in a vegetative state or subsequently succumbed to their condition, and ~20% had brain damage...
April 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29657712/recent-advances-in-understanding-the-biology-of-marginal-zone-lymphoma
#14
REVIEW
Francesco Bertoni, Davide Rossi, Emanuele Zucca
There are three different marginal zone lymphomas (MZLs): the extranodal MZL of mucosa-associated lymphoid tissue (MALT) type (MALT lymphoma), the splenic MZL, and the nodal MZL. The three MZLs share common lesions and deregulated pathways but also present specific alterations that can be used for their differential diagnosis. Although trisomies of chromosomes 3 and 18, deletions at 6q23, deregulation of nuclear factor kappa B, and chromatin remodeling genes are frequent events in all of them, the three MZLs differ in the presence of recurrent translocations, mutations affecting the NOTCH pathway, and the transcription factor Kruppel like factor 2 ( KLF2) or the receptor-type protein tyrosine phosphatase delta ( PTPRD )...
2018: F1000Research
https://www.readbyqxmd.com/read/29653367/upregulation-of-lncrna-plncrna-1-indicates-the-poor-prognosis-and-promotes-glioma-progression-by-activation-of-notch-signal-pathway
#15
Xiaolong Wang, Yungang Yan, Chunman Zhang, Wei Wei, Xin Ai, Yongbin Pang, Ying Bian
Prostate cancer-up-regulated long noncoding RNA 1(PlncRNA-1) has been demonstrated to be increased in several cancers, which plays an oncogenic role in the development of cancer. However, the exact functions and molecular mechanism of PlncRNA-1 in the tumorigenesis of glioma has not been studied. In present work, we firstly identified that PlncRNA-1 expression levels were prominently augmented in glioma patient tissues and glioma cell lines compared with adjacent noncancerous tissue and normal cells, respectively...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29649410/sca1-lin-cd117-mouse-bone-marrow-derived-mesenchymal-stem-cells-regulate-immature-dendritic-cell-maturation-by-inhibiting-tlr4-irf8-signaling-via-the-notch-rbp-j-pathway
#16
Xingxia Liu, ShaoDa Ren, Chaozhuo Ge, Kai Cheng, Xiaojing Li, Robert Chunhua Zhao
Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they hold great promise for treating various immune disorders. However, their regulatory effects on the maturation of immature dendritic cells (imDCs) are not fully understood. Here, we show that Sca-1+Lin-CD117-MSCs restrain the LPS-stimulated maturation transition of imDCs co-cultured without exogenous cytokines. The Notch signaling pathway plays a critical role in the process by controlling IRF8 expression in an RBP-J-dependent manner...
March 13, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29648608/rab39a-a-rab-small-gtpase-with-a-prominent-role-in-cancer-stemness
#17
Tokuhiro Chano, Sofia Avnet
RAB39A is a Rab small GTPase that localizes at distinct subcellular compartments and regulates intracellular membrane trafficking pathways in vertebrate cells. RAB39A interacts with various molecules and modulates vesicular trafficking that regulates multiple biological pathways such as neuronal differentiation and/or autophagy. Among these pathways are Hippo and Notch signalings, microtubular organization, and mitophagy/autophagy. Although RAB39A has never been studied in cancer biology, it has been recently shown to promote cancer stemness and tumorigenesis...
April 10, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29643502/unravelling-disparate-roles-of-notch-in-bladder-cancer
#18
REVIEW
Akihiro Goriki, Roland Seiler, Alexander W Wyatt, Alberto Contreras-Sanz, Akshay Bhat, Akio Matsubara, Tetsutaro Hayashi, Peter C Black
The Notch pathway has been implicated in both oncogenic and tumour-suppressive roles in cancer depending on the tissue type and cellular context. However, until recently, little was known about the pathway in bladder cancer. Studies have revealed that NOTCH1 copy number and expression are decreased in bladder cancer and NOTCH1 activation in bladder cancer cell lines reduces proliferation, suggesting that NOTCH1 acts as a tumour suppressor. Furthermore, in transgenic models, bladder cancer is promoted by bladder-specific inactivation of a component of the γ-secretase complex, which liberates the intracellular domain of neurogenic locus Notch homologue protein (NOTCH) and starts the signalling cascade...
April 11, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29642462/new-challenges-in-targeting-signaling-pathways-in-acute-lymphoblastic-leukemia-by-ngs-approaches-an-update
#19
REVIEW
Adrián Montaño, Maribel Forero-Castro, Darnel Marchena-Mendoza, Rocío Benito, Jesús María Hernández-Rivas
The identification and study of genetic alterations involved in various signaling pathways associated with the pathogenesis of acute lymphoblastic leukemia (ALL) and the application of recent next-generation sequencing (NGS) in the identification of these lesions not only broaden our understanding of the involvement of various genetic alterations in the pathogenesis of the disease but also identify new therapeutic targets for future clinical trials. The present review describes the main deletions, amplifications, sequence mutations, epigenetic lesions, and new structural DNA rearrangements detected by NGS in B-ALL and T-ALL and their clinical importance for therapeutic procedures...
April 7, 2018: Cancers
https://www.readbyqxmd.com/read/29630035/an-optogenetic-method-to-control-and-analyze-gene-expression-patterns-in-cell-to-cell-interactions
#20
Akihiro Isomura, Ryoichiro Kageyama
Cells should respond properly to temporally changing environments, which are influenced by various factors from surrounding cells. The Notch signaling pathway is one of such essential molecular machinery for cell-to-cell communications, which plays key roles in normal development of embryos. This pathway involves a cell-to-cell transfer of oscillatory information with ultradian rhythms, but despite the progress in molecular biology techniques, it has been challenging to elucidate the impact of multicellular interactions on oscillatory gene dynamics...
March 22, 2018: Journal of Visualized Experiments: JoVE
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