Ryota Kobayashi, Miki Sakazaki, Yukie Nagai, Takanobu Okamoto, Yuto Hashimoto, Kaori Sato, Shotaro Seki, Urara Hata, Kazuki Esaki, Ryuya Tanigawa, Amane Mitsuoka, Akiko Funaki, Yasuhiro Niki, Takeo Hashiguchi, Hideyuki Negoro
Endothelin-1 (ET-1), produced by vascular endothelial cells, plays a pivotal role in the regulation of vascular tone. Isomaltulose, a naturally occurring sweetener and structural isomer of sucrose, reduces postprandial hyperglycemia, but its effect on arteriosclerosis due to hyperglycemia is unknown. The effects of 12 weeks of isomaltulose administration on ET-1 levels, a peptide that regulates arterial stiffness, blood pressure, and vascular tone, were tested before and after an oral glucose tolerance test...
September 30, 2023: Heart and Vessels