Anthony E Pusateri, Clifford G Morgan, Leslie E Neidert, Michael M Tiller, Jacob J Glaser, Richard B Weiskopf, Ismaeel Ebrahim, Willem Stassen, Sanjeev Rambharose, Scott H Mahoney, Lee A Wallis, Ewell M Hollis, Gerald T Delong, Sylvain Cardin
OBJECTIVES: Prehospital transfusion can be life-saving when transport is delayed but conventional plasma, red cells, and whole blood are often unavailable out of hospital. Shelf-stable products are needed as a temporary bridge to in-hospital transfusion. Bioplasma FDP (freeze-dried plasma) and Hemopure (hemoglobin-based oxygen carrier; HBOC) are products with potential for prehospital use. In vivo use of these products together has not been reported. This study assessed the safety of intravenous administration of HBOC+FDP, relative to normal saline (NS), in rhesus macaques (RM)...
2024: Trauma Surgery & Acute Care Open