keyword
MENU ▼
Read by QxMD icon Read
search

IgG4-related disease

keyword
https://www.readbyqxmd.com/read/28725444/post-tuberculous-fibrosing-mediastinitis-a-review-of-the-literature
#1
REVIEW
Zhe Wu, Hannah Jarvis, Luke S Howard, Corrina Wright, Onn Min Kon
Fibrosing mediastinitis (FM) is a rare disease where there is thickening of the fibrous tissue in the mediastinum. While histoplasmosis is the the most common recognised cause, the link with tuberculosis (TB) has been rarely documented. We review the link between TB and FM, and describe a case of probable TB-related FM.Our case is of a 74-year-old man who presented with breathlessness 3 years after fully treated TB. Scans revealed a calcified soft tissue mass within the mediastinum, and a diagnosis of fibrosing mediastinitis resulting in pulmonary hypertension was made...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28720475/a-case-of-igg4-related-disease-presenting-with-multiple-gastric-submucosal-tumors
#2
Shoichiro Mine, Eisuke Ozawa, Ken Ohnita, Kuniko Abe, Kazuhiko Nakao
No abstract text is available yet for this article.
July 15, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28717084/pathologically-proven-spontaneous-remission-of-igg4-related-retroperitoneal-fibrosis
#3
Hideaki Yamakawa, Akimasa Sekine, Yumie Yamanaka, Shinko Sadoyama, Tomohisa Baba, Eri Hagiwara, Koji Okudela, Takashi Ogura
Some forms of idiopathic retroperitoneal fibrosis (RF) have recently been considered to be a part of the spectrum of immunoglobulin G4 (IgG4)-related disease. This case report is the first description of a spontaneous remission in a patient with pathologically proven IgG4-related RF. Although the pathogenesis and long-term disease behavior of IgG4-related RF remains unknown, we believe that an initial assessment consisting of only careful monitoring might be one important strategy, especially in asymptomatic IgG4-related RF patients without nephropathy, while carefully monitoring these patients for the risk of recurrence...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28716871/igg4-related-disease-long-term-natural-history-and-management-of-a-relapsing-multisystem-disease-entity
#4
Sreelakshmi Kotha, Giovanni Tritto, Terry Wong, Philip Berry
Although awareness of IgG4-related disease has grown over the past decade, with earlier diagnosis and treatment, understanding of its natural history over the long term and the optimal management remains unclear. We report the case of a 48-year-old man who presented with a pancreatic pseudotumour causing bile duct obstruction with coexisting autoimmune hepatitis and multisystem involvement. His symptoms settled on steroids and maintenance with azathioprine was commenced, however periodic relapses occurred involving multiple organs...
July 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28710703/igg4-related-disease-involving-polyserous-effusions-with-elevated-serum-interleukin-6-levels-a-case-report-and-literature-review
#5
Xiang Tong, Min Bai, Weiya Wang, Qingbing Han, Panwen Tian, Hong Fan
Immunoglobulin G4-related disease (IgG4-RD) is a recently described immune-mediated fibroinflammatory disease with a characteristic histopathologic appearance that can affect various organs. We report a 43-year-old Chinese female patient with IgG4-RD involving polyserous effusions with reports of worsening exertional dyspnea for 3 months. Laboratory blood tests revealed that serum interleukin (IL)-6, carbohydrate antigens (CA-199 and CA-125), and alpha-fetoprotein levels were significantly increased, but serum IgG4 levels were normal...
July 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28710538/-manifestations-of-autoimmune-disorders-in-otorhinolaryngology-classical-symptoms-and-diagnostic-approach
#6
B Hofauer, A Chaker, K Thürmel, A Knopf
Manifestations of autoimmune disorders represent a diagnostic challenge. Many autoimmune disorders show typical manifestations in the ear, nose and throat and should be taken into account in the differential diagnosis. Sjogren's syndrome, various vasculitides and sarcoidosis represent the most common autoimmune disorders in otorhinolaryngology, but IgG4-related diseases, relapsing polychondritis and autoimmune disorders of the mucosa are also observed. Autoimmune diseases can lead to sensorineural deficits...
July 14, 2017: HNO
https://www.readbyqxmd.com/read/28701054/diagnostic-and-treatment-workup-for-igg4-related-disease
#7
Mary Abraham, Arezou Khosroshahi
IgG4-Related Disease is a newly recognized condition which is increasingly diagnosed by practitioners due to improvement in clinical awareness. Men and women have been found to be affected by this disease in various organs, more commonly with involvement of the salivary and lacrimal glands as well as pancreas and liver. Areas Covered: The diagnosis and management of this condition remain challenging as biomarkers and therapies are being investigated. Hallmark features on histology are still the gold standard for confirmation of diagnosis, whereas serum IgG4 level has been shown to be neither necessary nor sufficient for the diagnosis...
July 12, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28700400/treatment-of-pediatric-igg4-related-orbital-disease-with-tnf-%C3%AE-inhibitor
#8
Sanjai Jalaj, Kristen Dunbar, Ashley Campbell, Michael Kazim
The authors describe a 9-year-old female who presented with swelling, proptosis, and tenderness of the right upper eyelid and MRI imaging demonstrating right lacrimal gland enlargement. After failing treatment with corticosteroids, the patient underwent a biopsy that was consistent with IgG4-related orbital disease. She was subsequently successfully treated with adalimumab (TNF-α inhibitor). This is the first case report of the successful use of a TNF-α inhibitor for the treatment of IgG4-related orbital disease in a child...
July 10, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28681251/igg4-related-disease-a-complex-under-diagnosed-clinical-entity
#9
REVIEW
Sujani Yadlapati, Elijah Verheyen, Petros Efthimiou
IgG4-related disease (IgG4-RD) encompasses a spectrum of complex fibro-inflammatory disorders which are often under diagnosed due to unfamiliarity by clinicians. A challenging multitude of clinical manifestations makes the diagnosis cumbersome. The primary clinical feature in IgG4-RD entails a tumor-like presentation coupled with tissue-destructive lesions. Histopathological findings include lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. These findings, in combination with elevated serum immunoglobulin G4 levels, are diagnostic in the setting of single- or multi-organ involvement...
July 5, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28643686/-pachymeningitis-associated-with-igg4-disease
#10
Dan Zimelewicz Oberman, Carolina Cuello Oderiz, Matteo Baccanelli, Silvia Christiansen, María Cristina Zurrú
Hypertrophic pachymeningitis is an infrequent disorder. It can be idiopathic or secondary to infectious, autoimmune or neoplastic disease. The recently described 〈IgG4-related disease〉 could be the origin of many cases considered cryptogenic. We present the case of a 60-year-old man, with a history of headache and episcleritis in both eyes, with partial response to corticoid therapy. The brain MR study with gadolinium showed enhancement and thickening of the dura mater, extending from lateral wall of left temporal and occipital lobes to ipsilateral tentorium...
2017: Medicina
https://www.readbyqxmd.com/read/28639844/diagnostic-sensitivity-of-cutoff-values-of-igg4-positive-plasma-cell-number-and-igg4-positive-cd138-positive-cell-ratio-in-typical-multiple-lesions-of-patients-with-igg4-related-disease
#11
Ichiro Mizushima, Kazunori Yamada, Kenichi Harada, Shoko Matsui, Takako Saeki, Satoru Kondo, Masayuki Takahira, Yuko Waseda, Yasuhito Hamaguchi, Hiroshi Fujii, Masakazu Yamagishi, Mitsuhiro Kawano
OBJECTIVES: This study aimed to investigate the diagnostic sensitivity of the cutoff values of IgG4-positive plasma cell (PC) number and IgG4-positive/CD138-positive cell ratio proposed by the International consensus statement (ICS) on the pathology of IgG4-related disease (IgG4-RD) in typical multiple lesions of patients with IgG4-RD. METHODS: We evaluated IgG4-positive PC number and IgG4-positive/CD138-positive cell ratio in 39 samples from 18 IgG4-RD patients having more than two typical lesions of IgG4-RD...
June 22, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28626183/desquamative-interstitial-pneumonia-complicated-with-igg4-related-lung-disease
#12
Hideaki Yamakawa, Yoshihiro Suido, Shinko Sadoyama, Yumie Yamanaka, Satoshi Ikeda, Hideya Kitamura, Tomohisa Baba, Koji Okudela, Tamiko Takemura, Takashi Ogura
As an idiopathic interstitial pneumonia, desquamative interstitial pneumonia (DIP) is an uncommon form of interstitial lung disease and is considered to be a smoking- or dust inhalation-related interstitial pneumonia in the majority of cases. However, the details regarding immunoglobulin G4 (IgG4)-related lung disease remain unclear and controversial. We herein report the first case of DIP complicated with IgG4-related lung disease. Even if a patient has a smoking history, we emphasize the importance of exploring the association between DIP and IgG4-related lung disease to clarify the pathogenesis of these two disorders...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28625638/development-of-psoriatic-arthritis-during-nivolumab-therapy-for-metastatic-non-small-cell-lung-cancer-clinical-outcome-analysis-and-review-of-the-literature
#13
Juan Ruiz-Bañobre, Eva Pérez-Pampín, Jorge García-González, Antonio Gómez-Caamaño, Francisco Javier Barón-Duarte, Rafael López-López, Francisca Vázquez-Rivera
Lung cancer is the leading cause of cancer-related death worldwide. The most common type, non-small cell lung cancer (NSCLC), is further divided into two main types, squamous cell and non-squamous cell (which includes adenocarcinoma). Nivolumab, a fully human IgG4 programmed death-1 immune checkpoint inhibitor antibody, has shown not only an overall survival advantage when compared to docetaxel, but also a relatively good side-effect profile among patients with previously treated advanced squamous and non-squamous NSCLC...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28621822/cdna-microarray-analysis-identifies-nr4a2-as-a-novel-molecule-involved-in-the-pathogenesis-of-sj%C3%A3-gren-s-syndrome
#14
Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Masafumi Moriyama, Isao Matsumoto, Seiji Nakamura, Takayuki Sumida
OBJECTIVE: To examine genes expressed specifically in labial salivary glands (LSGs) of patients with Sjögren's syndrome (SS) in comparison with those of patients with IgG4-related disease (IgG4-RD) and to identify the genes involved in the pathogenesis of SS. METHODS: Gene expression in LSGs of SS patients, IgG4-RD patients and healthy controls (HC) was analyzed by cDNA microarray. Quantitative PCR (qPCR) was used to validate the up-regulation of differentially expressed genes (DEGs) in SS...
June 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28617941/association-of-igg4-and-free-light-chain-with-idiopathic-pleural-effusion
#15
Yoriyuki Murata, Keisuke Aoe, Yuka Mimura-Kimura, Tomoyuki Murakami, Keiji Oishi, Tsuneo Matsumoto, Hiroshi Ueoka, Kazuto Matsunaga, Masafumi Yano, Yusuke Mimura
The cause of pleural effusion remains uncertain in approximately 15% of patients despite exhaustive evaluation. As recently described IgG4-related disease is a fibroinflammatory disorder that can affect various organs including the lungs, we investigate whether idiopathic pleural effusion includes IgG4-associated etiology. Between 2000 and 2012, we collected 830 pleural fluid samples and reviewed 35 patients with pleural effusions undiagnosed after pleural biopsy at Yamaguchi-Ube Medical Center. Importantly, IgG4 immunostaining revealed infiltration of IgG4-positive plasma cells in the pleura of 12 patients (34%, IgG4+ group)...
June 15, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28614225/immunoglobulin-g4-related-disease-preceded-by-lung-involvement-a-case-report
#16
Miki Abo, Hazuki Takato, Satoshi Watanabe, Kazumasa Kase, Tamami Sakai, Hayato Koba, Johsuke Hara, Takashi Sone, Hideharu Kimura, Kazuo Kasahara
RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is a systemic condition involving various organs and vessels including the pancreas, bile duct, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, meninges, and aorta. Recently, some cases of IgG4-RD have been reported, in which only pulmonary lesions were present. It is not known whether IgG4-RD can be diagnosed on the basis of pulmonary lesions only, because increases in serum IgG4 levels and infiltration of IgG4-positive plasma cells into the lung tissue also occur in other inflammatory conditions...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28614220/rituximab-was-used-to-treat-recurrent-igg4-related-hypophysitis-with-ophthalmopathy-as-the-initial-presentation-a-case-report-and-literature-review
#17
REVIEW
Wei-Jun Gu, Qian Zhang, Jian Zhu, Jie Li, Shi-Hui Wei, Yi-Ming Mu
RATIONALE: Immunoglobulin G4 (IgG4)-related hypophysitis is a type of IgG4-related disease (IgG4-RD), which is characterized by plasma cells infiltration in the pituitary causing functional changes and (or) space-occupying effect in the pituitary. IgG4-related hypophysitis is sensitive to hormone therapy in most patients, but recurrence is very likely. PATIENT CONCERNS: Here, we report a 57-year-old male patient with bilateral eye redness as the initial presentation...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28612666/igg4-related-sclerosing-disease-of-the-breast-in-a-male-patient
#18
Taisia Vitkovski, Galina S Marder, Dominic A Filardi, Ekta Gupta, Frank Breuer
IgG4-related sclerosing disease of the breast is a rare entity with 10 reports in the literature. We report the first case in a male patient. A 48-year-old male presented with 4-week history of palpable right upper outer quadrant breast mass associated with skin puckering. He reported a family history of breast cancer in his aunt. Ultrasound and mammography showed a spiculated 2.5-cm mass associated with skin retraction with extension to the pectoralis muscle. Ultrasound-guided core biopsy was performed. The findings were interpreted as acute and chronic inflammatory process...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28607901/igg4-related-disease-igg4-rd-presenting-as-a-mass-in-the-carotid-triangle-masquerading-paraganglioma
#19
T Ramadass, V Balaji, S K J Sheba, K S Vali Ahmed, Raees Abdurahiman
IgG4-related disease (IgG4-RD) which is a protein disorder presented as a mass in the right carotid triangle in a 30 year male patient, who underwent battery of tests is described. The radiologist opined the mass as paraganglioma and the spindle shaped character of the mass also suggested neurogenic tumor in differential diagnosis. Reference to vascular surgeon also opined the same, and adviced for incisional biopsy. Histopathology report suggested IgG4-RD and immunochemistry confirmed the final diagnosis...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28600554/seroconversion-to-lutzomyia-intermedia-linb-13-as-a-biomarker-for-developing-cutaneous-leishmaniasis
#20
Augusto M Carvalho, Kiyoshi F Fukutani, Rohit Sharma, Rebecca P Curvelo, José Carlos Miranda, Aldina Barral, Edgar M Carvalho, Jesus G Valenzuela, Fabiano Oliveira, Camila I de Oliveira
Sand flies inject saliva while feeding in the vertebrate host and anti-saliva antibodies can be used as biomarkers of exposure to Leishmania vectors. We expressed recombinant salivary proteins from Lutzomyia intermedia, a vector of Leishmania braziliensis, and evaluated the seroreactivity in exposed individuals in search for exposure markers. We found a strong correlation among positive serology to recombinant proteins LinB-13, 26, 15, 21 and to salivary proteins: rLinB-13 was the top performing molecule; IgG4 was the most predominant antibody subclass and antibodies to rLinB-13 did not cross react with Lu...
June 9, 2017: Scientific Reports
keyword
keyword
79229
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"