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https://www.readbyqxmd.com/read/29344250/prevention-of-body-weight-loss-and-sarcopenia-by-a-novel-selective-androgen-receptor-modulator-in-cancer-cachexia-models
#1
Megumi Morimoto, Katsuji Aikawa, Takahito Hara, Masuo Yamaoka
Cancer cachexia is a syndrome that impairs the quality of life and overall survival of patients, and thus the effectiveness of anticancer agents. There are no effective therapies for cancer cachexia due to the complexity of the syndrome, and insufficient knowledge of its pathogenesis results in difficulty establishing appropriate animal models. Previously, promising results have been obtained in clinical trials using novel agents including the ghrelin receptor agonist anamorelin, and the selective androgen receptor modulator (SARM) enobosarm to treat cachexia in patients with cancer...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29335018/danggwijagyaksan-for-climacteric-syndrome-in-peri-and-postmenopausal-women-with-a-blood-deficiency-dominant-pattern-study-protocol-for-a-randomized-double-blind-placebo-controlled-pilot-trial
#2
Mikyung Kim, Ae-Ran Kim, Hyo-Ju Park, Ojin Kwon, Joo-Hee Kim, Eun-Ji Park, Seon-Eun Baek, Jeong-Eun Yoo, Jun-Hwan Lee
BACKGROUND: This study aims to explore the safety, efficacy, and feasibility of Danggwijagyaksan (DJS) for alleviating climacteric syndrome in peri- and postmenopausal women with a blood-deficiency dominant pattern. METHODS/DESIGN: This is a randomized, double-blind, placebo-controlled pilot clinical trial. A total of 34 women with climacteric syndrome who have signed informed consent forms will be registered in this study. Placebo or DJS will be randomly assigned to the participants in an equal proportion...
January 15, 2018: Trials
https://www.readbyqxmd.com/read/29333569/an-integrated-fuzzy-based-advanced-eutrophication-simulation-model-to-develop-the-best-management-scenarios-for-a-river-basin
#3
Rallapalli Srinivas, Ajit Pratap Singh
Assessment of water quality status of a river with respect to its discharge has become prerequisite to sustainable river basin management. The present paper develops an integrated model for simulating and evaluating strategies for water quality management in a river basin management by controlling point source pollutant loadings and operations of multi-purpose projects. Water Quality Analysis and Simulation Program (WASP version 8.0) has been used for modeling the transport of pollutant loadings and their impact on water quality in the river...
January 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29332730/biomechanical-factors-associated-with-running-economy-and-performance-of-elite-kenyan-distance-runners-a-systematic-review
#4
REVIEW
Nassib Tawa, Quinette Louw
BACKGROUND: Running economy (RE) is a determinant of performance in endurance sports and is a complex multi-factorial measure which reflects the combined functioning of bio-mechanical, neuro-muscular, metabolic and cardio-respiratory factors some of which are hereditary or adapt to coaching. Kenyan distance runners have dominated major global events with their unmatched performance for decades and this phenomenon has prompted several investigations aimed at establishing possible factors associated with their performance...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29324550/effectiveness-of-the-lean-process-compared-to-other-quality-improvement-initiatives-on-length-of-stay-and-wait-times-in-healthcare-organizations-a-systematic-review-protocol
#5
Lisa C Honeycutt, Sheila D Keller
What is the effectiveness of the Lean process compared to other quality improvement initiatives on length of stay and wait times in healthcare organizations?
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29316987/diet-nutrition-and-the-ageing-brain-current-evidence-and-new-directions
#6
Katie Moore, Catherine F Hughes, Mary Ward, Leane Hoey, Helene McNulty
Globally populations are ageing. By 2050, it is estimated that there will be two billion people aged 60 years or over, of which 131 million are projected to be affected by dementia, while depression is predicted to be the second leading cause of disability worldwide by 2020. Preventing or delaying the onset of these disorders should therefore be a public health priority. There is some evidence linking certain dietary patterns, particularly the Mediterranean diet, with a reduced risk of dementia and depression...
January 10, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29315350/gluteal-muscle-damage-leads-to-higher-in-vivo-hip-joint-loads-3-months-after-total-hip-arthroplasty
#7
Philipp Damm, Jip Zonneveld, Sophie Brackertz, Florian Streitparth, Tobias Winkler
BACKGROUND: Total hip arthroplasty (THA) is in most cases improving patients´ life quality immediately after surgery. However, a closer look at these patients, especially with modern gait analysis methods, reveals also negative consequences due to the surgical approach related injury to the pelvic muscles. We hypothesized that this damage will have a negative impact on hip joint contact forces during activities of daily living (ADL). METHODS: 10 patients undergoing THA received an instrumented hip joint implant enabling real time in vivo measurements of hip joint loads using a direct lateral approach...
2018: PloS One
https://www.readbyqxmd.com/read/29315169/health-benefits-of-an-innovative-exercise-program-for-mitochondrial-disorders
#8
Carmen Fiuza-Luces, Jorge Díez-Bermejo, Miguel Fernández-de la Torre, Gabriel Rodríguez-Romo, Paz Sanz-Ayán, Aitor Delmiro, Diego Munguía-Izquierdo, Irene Rodríguez-Gómez, Ignacio Ara, Cristina Domínguez-González, Joaquín Arenas, Miguel A Martín, Alejandro Lucia, María Morán
PURPOSE: We determined the effects of an innovative 8-week exercise intervention (aerobic, resistance and inspiratory muscle training) for patients with mitochondrial disease (MD). METHODS: Several endpoints were assessed in 12 patients (19-59 years, 4 female) at pre-training, post-training and after 4-week detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main endpoints), ability to perform activities of daily living (ADL), body composition, quality of life and blood myokines (secondary endpoints)...
January 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29302374/using-quality-of-life-scales-with-nutritional-relevance-after-gastrectomy-a-challenge-for-providing-personalized-treatment
#9
Seung Soo Lee, Wansik Yu, Ho Young Chung, Oh Kyoung Kwon, Won Kee Lee
Purpose: This study evaluated the changes in nutritional status based on quality of life (QoL) item-level analysis to determine whether individual QoL responses might facilitate personal clinical impact. Materials and Methods: This study retrospectively evaluated QoL data obtained by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Stomach (QLQ-STO22) as well as metabolic-nutritional data obtained by bioelectrical impedance analysis and blood tests...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29297385/tailoring-nutrition-therapy-to-illness-and-recovery
#10
REVIEW
Paul E Wischmeyer
Without doubt, in medicine as in life, one size does not fit all. We do not administer the same drug or dose to every patient at all times, so why then would we live under the illusion that we should give the same nutrition at all times in the continuum of critical illness? We have long lived under the assumption that critical illness and trauma lead to a consistent early increase in metabolic/caloric need, the so-called "hypermetabolism" of critical illness. What if this is incorrect? Recent data indicate that early underfeeding of calories (trophic feeding) may have benefits and may require consideration in well-nourished patients...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29280903/framework-for-research-on-implementation-of-process-redesigns
#11
Mahima Ashok, Dorothy Hung, Lucia Rojas-Smith, Michael T Halpern, Michael Harrison
BACKGROUND: Complex system interventions benefit from close attention to factors affecting implementation and resultant outcomes. This article describes a framework for examining these factors in process redesign (PR) and for assessing PR outcomes. METHODS: Using literature scans and expert comment on draft frameworks based on the Consolidated Framework for Implementation Research, a team of researchers developed the PR framework for the Agency for Healthcare Research and Quality...
January 2018: Quality Management in Health Care
https://www.readbyqxmd.com/read/29237852/cues-of-upper-body-strength-account-for-most-of-the-variance-in-men-s-bodily-attractiveness
#12
Aaron Sell, Aaron W Lukazsweski, Michael Townsley
Evolution equips sexually reproducing species with mate choice mechanisms that function to evaluate the reproductive consequences of mating with different individuals. Indeed, evolutionary psychologists have shown that women's mate choice mechanisms track many cues of men's genetic quality and ability to invest resources in the woman and her offspring. One variable that predicted both a man's genetic quality and his ability to invest is the man's formidability (i.e. fighting ability or resource holding power/potential)...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29233485/body-fat-affects-mouse-reproduction-ovarian-hormone-release-and-response-to-follicular-stimulating-hormone
#13
Alexander V Sirotkin, Dušan Fabian, Janka Babeľová Kubandová, Radoslava Vlčková, Saleh Alwasel, Abdel Halim Harrath
We investigated the effects of body fat content on mouse fecundity, ovarian hormone release, and their response to follicle stimulation hormone (FSH). 4 types of females were produced: lean (group 1), normal (group 2), slightly fat (group 3), and significantly fat (group 4). The body weights, fat content, fertility rate, embryo number produced, retarded and degenerated embryo percentage, the release of progesterone (P4), testosterone (T), and insulin-like growth factor I (IGF-I) by isolated ovaries cultured with and without FSH (1...
December 7, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29231963/body-composition-in-long-term-survivors-of-acute-lymphoblastic-leukemia-diagnosed-in-childhood-and-adolescence-a-focus-on-sarcopenic-obesity
#14
Christopher J C Marriott, Lesley F Beaumont, Troy H Farncombe, Amy N Cranston, Uma H Athale, Valerie N Yakemchuk, Colin E Webber, Ronald D Barr
BACKGROUND: The late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity. METHODS: A cross-sectional study of body composition was undertaken via dual-energy x-ray absorptiometry in 75 long-term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat-free mass (equivalent to the lean body mass [LBM]), and whole-body bone mineral content...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29224976/body-composition-and-clinical-symptoms-in-patients-with-hip-or-knee-osteoarthritis-results-from-the-khoala-cohort
#15
Clémence Jeanmaire, Bernard Mazières, Evelyne Verrouil, Lorraine Bernard, Francis Guillemin, Anne-Christine Rat
OBJECTIVE: To analyze the associations between body composition, notably low lean mass, and clinical symptoms [pain, physical function, quality of life (QoL)] in patients with symptomatic hip and/or knee OA. METHODS: Cross-sectional study using data from the 3-year follow-up visit of the Knee and Hip OsteoArthritis Long-term assessment (KHOALA) cohort. Skeletal muscle and fat mass were measured by dual X-ray absorptiometry (DXA). Fat mass index (FMI) was defined as total fat mass/height2...
October 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29224861/a-survey-of-selected-animal-based-measures-of-dairy-cattle-welfare-in-the-eastern-alps-toward-context-based-thresholds
#16
A Zuliani, M Mair, M Kraševec, I Lora, M Brscic, G Cozzi, C Leeb, M Zupan, C Winckler, S Bovolenta
In the Alps, traditional dairy farms are small-scale operations where vertical transhumance from valley indoor housing systems to highland pasture-based systems is still practiced in summer. Vertical transhumance implies a substantial change of environment, available resources, and management practices from one season to another. In such systems, animal-based welfare measures need to be monitored throughout the year to capture the variation of welfare outcomes, based on which targeted welfare management plans can be implemented...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#17
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29221645/primary-care-led-weight-management-for-remission-of-type-2-diabetes-direct-an-open-label-cluster-randomised-trial
#18
Michael Ej Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Carl Peters, Sviatlana Zhyzhneuskaya, Ahmad Al-Mrabeh, Kieren G Hollingsworth, Angela M Rodrigues, Lucia Rehackova, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Hazel M Ross, Yvonne McIlvenna, Renae Stefanetti, Michael Trenell, Paul Welsh, Sharon Kean, Ian Ford, Alex McConnachie, Naveed Sattar, Roy Taylor
BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2 diabetes. METHODS: We did this open-label, cluster-randomised trial (DiRECT) at 49 primary care practices in Scotland and the Tyneside region of England. Practices were randomly assigned (1:1), via a computer-generated list, to provide either a weight management programme (intervention) or best-practice care by guidelines (control), with stratification for study site (Tyneside or Scotland) and practice list size (>5700 or ≤5700)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29221501/lean-methodology-reduces-inappropriate-use-of-antipsychotics-for-agitation-at-a-psychiatric-hospital
#19
Joshana K Goga, Antonio Depaolo, Sunil Khushalani, J Ken Walters, Robert Roca, Marc Zisselman, Christopher Borleis
OBJECTIVE: To Evaluate the Effects of Applying Lean Methodology-Improving Quality Increasing Efficiency by Eliminating Waste and Reducing Costs-An Approach To Decrease the Prescribing Frequency of Antipsychotics for The Indication of Agitation. DESIGN: Historically Controlled Study. SETTING: Bheppard Pratt Health System is the Largest Private Provider of Psychiatric Care in Maryland With a Total Bed Capacity of 300. There Were 4 337 Patient Days From November 1 2012 to October 31 2013 on the Dementia Unit...
January 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29215962/personal-exposure-to-fine-particulate-matter-concentrations-in-central-business-district-of-a-tropical-coastal-city
#20
Jyothi S Menon, S M Shiva Nagendra
In the present study, personal exposure to fine particulate matter (PM2.5) concentrations in an urban hotspot (CBD: central business district) was investigated. The PM monitoring campaigns were carried out at an urban hotspot from June to October 2015. The personal exposure monitoring was performed during three different time periods, i.e. morning (8AM -9AM), afternoon (12.30PM-1.30PM) and evening (4PM-5PM), to cover both the peak and lean hour activities of the CBD. The median PM2.5 concentrations were 38...
December 7, 2017: Journal of the Air & Waste Management Association
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