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https://www.readbyqxmd.com/read/29791782/obesity-leads-to-impairments-in-the-morphology-and-organization-of-human-skeletal-muscle-lipid-droplets-and-mitochondrial-networks-which-are-resolved-with-gastric-bypass-surgery-induced-improvements-in-insulin-sensitivity
#1
Marianne D Kristensen, Signe M Petersen, Kjestine E Møller, Michael T Lund, Merethe Hansen, Christina N Hansen, Julie Courraud, Jørn W Helge, Flemming Dela, Clara Prats
AIMS: Skeletal muscle lipid stores and mitochondrial function have been appointed as key players in obesity-induced insulin resistance. However, there are conflicting reports in the literature based on in vitro quantitative measurements. Here we test the hypothesis that it is not the quantity but the quality that matters. METHODS: The present study combines quantitative and qualitative structural measurements of lipid stores and mitochondrial dynamics in skeletal muscle from lean subjects, and subjects with morbid obesity, with and without type 2 diabetes, before and after gastric bypass surgery...
May 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29790443/improvement-of-laboratory-turnaround-time-using-lean-methodology
#2
Shradha Gupta, Sahil Kapil, Monica Sharma
Purpose The purpose of this paper is to discuss the implementation of lean methodology to reduce the turnaround time (TAT) of a clinical laboratory in a super speciality hospital. Delays in report delivery lead to delayed diagnosis increased waiting time and decreased customer satisfaction. The reduction in TAT will lead to increased patient satisfaction, quality of care, employee satisfaction and ultimately the hospital's revenue. Design/methodology/approach The generic causes resulting in increasing TAT of clinical laboratories were identified using lean tools and techniques such as value stream mapping (VSM), Gemba, Pareto Analysis and Root Cause Analysis...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29788170/systematic-review-and-meta-analysis-of-the-evidence-for-oral-nutritional-intervention-on-nutritional-and-clinical-outcomes-during-chemo-radio-therapy-current-evidence-and-guidance-for-design-of-future-trials
#3
M A E de van der Schueren, A Laviano, H Blanchard, M Jourdan, J Arends, V E Baracos
Background: Driven by reduced nutritional intakes and metabolic alterations, malnutrition in cancer patients adversely affects quality of life, treatment tolerance and survival. We examined evidence for oral nutritional interventions during chemo(radio)therapy. Design: We carried out a systematic review of randomized controlled trials (RCT) with either dietary counseling (DC), high-energy oral nutritional supplements (ONS) aiming at improving intakes or ONS enriched with protein and n-3 polyunsaturated fatty acids (PUFA) additionally aiming for modulation of cancer-related metabolic alterations...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29778480/relationship-between-herd-size-and-measures-of-animal-welfare-on-dairy-cattle-farms-with-freestall-housing-in-germany
#4
Daniel Gieseke, Christian Lambertz, Matthias Gauly
The objective of this study was to examine the association of herd size with animal welfare in dairy cattle herds. Therefore, 80 conventional dairy cattle farms were classified by the number of cows into 4 herd size classes, C1 (<100 cows), C2 (100-299 cows), C3 (300-499 cows), and C4 (≥500 cows), and assessed using multiple animal-based measures of the Welfare Quality Assessment protocol for dairy cattle. Data were recorded from April 2014 to September 2016 by an experienced single assessor in Northern Germany...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29772768/within-and-between-individual-variability-of-exposure-to-work-related-musculoskeletal-disorder-risk-factors
#5
Mohsen Zare, Jean-Claude Sagot, Yves Roquelaure
Industrial companies indicate a tendency to eliminate variations in operator strategies, particularly following implementation of the lean principle. Companies believe when the operators perform the same prescribed tasks, they have to execute them in the same manner (completing the same gestures and being exposed to the same risk factors). They attempt to achieve better product quality by standardizing and reducing operational leeway. However, operators adjust and modify ways of performing tasks to balance between their abilities and the requirements of the job...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29771917/the-differentiation-of-preadipocytes-and-gene-expression-related-to-adipogenesis-in-ducks-anas-platyrhynchos
#6
Shasha Wang, Yang Zhang, Qi Xu, Xiaoya Yuan, Wangcheng Dai, Xiaokun Shen, Zhixiu Wang, Guobin Chang, Zhiquan Wang, Guohong Chen
Meat quality is closely related to adipose tissues in ducks, and adipogenesis is controlled by a complex network of transcription factors tightly acting at different stages of differentiation especially in ducks. The aim of this study was to establish the preadipocyte in vitro culture system and understand the biological characteristics of expansion of duck adipocyte tissue at the cellular and molecular level. We isolated pre-adipocytes from the subcutaneous fat of three breeds of duck and differentiated them into mature adipocytes using a mixture of insulin, rosiglitazone, dexamethasone, 3-isobutyl-1-methylxanthine, and oleic acid over 0,2, 4, 6, and 8 days...
2018: PloS One
https://www.readbyqxmd.com/read/29762047/imaging-of-suspected-pulmonary-embolism-and-deep-venous-thrombosis-in-obese-patients
#7
Vincent Cascio, Man Hon, Linda B Haramati, Animesh Gour, Peter Spiegler, Sanjeev Bhalla, Douglas Katz
Obesity is a growing problem around the world, and radiology departments frequently encounter difficulties related to large patient size. Diagnosis and management of suspected venous thromboembolism, in particular deep venous thrombosis (DVT) and pulmonary embolism (PE), are challenging even in some lean patients, and can become even more complicated in the setting of obesity. Many obstacles must be overcome to obtain imaging examinations in obese patients with suspected PE and/or DVT, and to ensure that these examinations are of sufficient quality to diagnose or exclude thromboembolic disease, or to establish an alternative diagnosis...
May 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29756982/clinical-nutritional-inflammatory-and-oxidative-stress-predictors-in-hemodialysis-mortality-a-review
#8
Andreza De Paula Santos Epifânio, Karla Pereira Balbino, Sonia Machado Rocha Ribeiro, Sylvia C C Franceschini, Helen Hermana Miranda Hermsdorff
The evaluation of clinical-nutrition status is essential to increase life quality and improve clinical outcomes of patients in hemodialysis (HD). In the absence of a gold standard, the goal of this integrative review was to present and discuss the latest scientific literature on the ability of clinical-nutritional indicators and inflammatory and oxidative stress markers to predict morbidity and mortality in HD. In this context, the lean and fat mass indexes have become good predictors of mortality in HD individuals, regardless of BMI...
January 18, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29751089/effect-of-obesity-on-patterns-and-mechanisms-of-injury-systematic-review-and-meta-analysis
#9
REVIEW
Tarn Stroud, N M Bagnall, Philip H Pucher
BACKGROUND: Trauma is one of the major causes of morbidity and mortality globally, especially in younger populations. With an increase in obesity globally, it is important to assess the potential differences in injury pattern and management of obese patients presenting with trauma compared to lean patients to try and improve patient care. This study aims to review the available literature comparing injury patterns between obese and non-obese patients. METHODS: A systematic review of articles which assessed the association between obesity and different patterns of trauma and injury were assessed...
May 8, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29750398/body-composition-fatigue-and-exercise-in-patients-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#10
Robert U Newton, Emily Jeffery, Daniel A Galvão, Carolyn McIntyre, Nigel Spry, David Joseph, Jim Denham, Dennis R Taaffe
OBJECTIVES: To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and following exercise in patients with prostate cancer already undergoing androgen deprivation therapy (ADT). SUBJECTS AND METHODS: Cross-sectional associations between lean and fat mass with fatigue and/or vitality measures were examined in 229 patients (43-90 years). Prospective analysis was undertaken in 129 patients who underwent 3-6 months exercise (predominantly resistance + aerobic)...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29737932/the-influence-of-preseason-training-phase-and-training-load-on-body-composition-and-its-relationship-with-physical-qualities-in-professional-junior-rugby-league-players
#11
Nick Dobbin, Adrian Gardner, Matt Daniels, Craig Twist
This study investigated changes in body composition in relation to training load determined using RPE and duration (sRPE), and its relationship with physical qualities over a preseason period. Sixteen professional academy players (age = 17.2 ± 0.7 years; stature = 179.9 ± 4.9 cm; body mass = 88.5 ± 10.1 kg) participated in the study. Body composition was assessed before and after each training phase and physical qualities assessed at the start and end of preseason. Across the whole preseason period, skinfold thickness, body fat percentage and fat mass were most likely lower (ES = -0...
May 8, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29726946/influence-of-feeding-thermally-peroxidized-soybean-oil-to-finishing-pigs-on-carcass-characteristics-loin-quality-and-shelf-life-of-loin-chops
#12
M F Overholt, G D Kim, D D Boler, B J Kerr, A C Dilger
The objective of this study was to evaluate the effect of feeding soybean oil (SO) with varying levels of peroxidation on carcass traits and shelf life of loins. Fifty-six barrows were randomly assigned to 1 of 4 diets containing 10% fresh SO (22.5°C) or thermally processed SO (45°C for 288 h, 90°C for 72 h, or 180°C for 6 h), each infused with air at a rate of 15L/min. Individually housed pigs were provided ad libitum access to feed for 81 d. At 82 d pigs were slaughtered and hot carcass weight (HCW) and liver weights were recorded...
May 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29725220/evaluation-of-the-quality-of-beef-patties-formulated-with-dried-pumpkin-pulp-and-seed
#13
M Serdaroğlu, H S Kavuşan, G İpek, B Öztürk
The objective of this study was to investigate quality attributes of beef patties formulated with dried pumpkin pulp and seed mixture (PM). Four different meatball formulations were prepared where lean was replaced with PM as C (0% PM), P2 (2% PM), P3 (3% PM) and P5 (5% PM). Utilization of PM decreased moisture and increased ash content of the patties. Incorporation of 5% PM (P5) increased the pH value of both uncooked and cooked patties compared to C group. Increasing levels of PM increased water-holding capacity...
February 2018: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29716978/therapy-of-endocrine-disease-growth-hormone-replacement-therapy-in-adults-thirty-years-of-personal-clinical-experience
#14
Jens Otto L Jorgensen, Anders Juul
The acute metabolic actions of purified human GH was first documented in adult hypopituitary patients more than 50 years ago, and placebo controlled long term GH trials in GH-deficient adults (GHDA) surfaced in 1989 with the availability of biosynthetic human GH. Untreated GHDA is associated with excess morbidity and mortality from cardiovascular disease and the phenotype includes fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular biomarkers...
May 1, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29712718/persisting-adverse-body-composition-changes-2-years-after-cessation-of-androgen-deprivation-therapy-for-localised-prostate-cancer
#15
Ada S Cheung, Alistair Tinson, Stefan Milevski, Rudolf Hoermann, Jd Zajac, Mathis Grossmann
OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associated with insulin resistance and decreased quality of life (QoL). Our objective was to assess whether adverse body composition changes improve after cessation of ADT. DESIGN: Prospective case-control study in a tertiary referral hospital. Thirty-four men newly commencing ADT (cases, median age 67.6 years [interquartile range 64.6, 72...
April 30, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29706143/genome-wide-association-studies-for-seven-production-traits-highlight-genomic-regions-useful-to-dissect-dry-cured-ham-quality-and-production-traits-in-duroc-heavy-pigs
#16
F Bertolini, G Schiavo, G Galimberti, S Bovo, M D'Andrea, M Gallo, L Buttazzoni, M F Rothschild, L Fontanesi
Protected designation of origin dry-cured hams are obtained from heavy pigs (slaughtered at about 160 kg of live weight). A specific breeding program designed to improve meat quality for this production has included as key traits the level of intermuscular fat between the leg muscles and ham weight loss during the seasoning period together with a balance between fat and lean cuts. In this study we carried out genome-wide association studies for seven traits used in the genetic merit of Italian Duroc heavy pigs, five related to meat and carcass quality traits (visible intermuscular fat, ham weight loss at first salting, backfat thickness, ham weight and lean cuts), and two related to performance and efficiency traits (average daily gain and feed : gain ratio)...
April 30, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29704862/a-nonrestrictive-weight-loss-diet-focused-on-fiber-and-lean-protein-increase
#17
Lijuan Zhang, Sherry Pagoto, Barbara Olendzki, Gioia Persuitte, Linda Churchill, Jessica Oleski, Yunsheng Ma
OBJECTIVE: We examined the feasibility and acceptability of a non-restrictive diet that was focused on increasing dietary fiber and lean protein intake for weight loss. METHODS: Dietary intake was assessed using three randomly selected 24-h dietary recalls. Fifteen obese adults enrolled in a 12-wk study that included six biweekly individual dietary counseling sessions to attain a daily goal of higher fiber (35 g/d) and lean protein (0.8 g/kg/d of individual's ideal body weight) intake...
March 22, 2018: Nutrition
https://www.readbyqxmd.com/read/29701774/associations-between-plasma-chemerin-concentrations-and-bone-quality-in-adults-from-the-general-population
#18
Lejla Kadric, Stephanie Zylla, Matthias Nauck, Henry Völzke, Nele Friedrich, Anke Hannemann
Chemerin is an adipokine associated with parameters of inflammation and the metabolic syndrome. Small observational studies suggested that high circulating chemerin levels are also related to bone erosion. We aimed to determine whether plasma chemerin levels are related to bone quality in the general population and to investigate the influence of body mass index (BMI) on that relation. For our analyses we obtained data from 3,583 adults who participated in the population-based Study of Health in Pomerania (SHIP)-Trend...
April 25, 2018: Endocrinology
https://www.readbyqxmd.com/read/29697274/effect-of-eicosapentaenoic-acid-on-body-composition-and-inflammation-markers-in-patients-with-head-and-neck-squamous-cell-cancer-from-a-public-hospital-in-mexico
#19
Obed Solís-Martínez, Valentina Plasa-Carvalho, Geraldine Phillips-Sixtos, Yanelly Trujillo-Cabrera, Arturo Hernández-Cuellar, Gloria E Queipo-García, Eduardo Meaney-Mendiolea, Guillermo M Ceballos-Reyes, Vanessa Fuchs-Tarlovsky
INTRODUCTION: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer. MATERIALS AND METHODS: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29681169/system-wide-lean-implementation-in-health-care-a-multiple-case-study
#20
Federica Centauri, Pamela Mazzocato, Stefano Villa, Marta Marsilio
Background Lean practices have been widely used by health care organizations to meet efficiency, performance and quality improvement needs. The lean health care literature shows that the effective implementation of lean requires a holistic system-wide approach. However, there is still limited evidence on what drives effective system-wide lean implementation in health care. The existing literature suggests that a deeper understanding of how lean interventions interact with the organizational context is necessary to identify the critical variables to successfully sustain system-wide lean strategies...
January 1, 2018: Health Services Management Research
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