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https://www.readbyqxmd.com/read/29149655/one-year-after-ischemic-stroke-changes-in-leg-movement-path-stability-in-a-speed-accuracy-task-but-no-major-effects-on-the-hands
#1
Albertas Skurvydas, Vilma Juodzbaliene, Tomas Darbutas, Marius Brazaitis
First year after the stroke is essential for motor recovery. The main motor control strategy (i.e., faster movement production at the expense of lower movement accuracy and stability, or greater movement accuracy and stability at the expense of slower movement) selected by poststroke patients during a unilateral speed-accuracy task (SAT) remains unclear. We aimed to investigate the poststroke (12 months after stroke) effects on the trade-off between movement speed and accuracy, and intraindividual variability during a motor performance task...
November 14, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29147660/analytical-validation-of-a-new-enzymatic-and-automatable-method-for-d-xylose-measurement-in-human-urine-samples
#2
Israel Sánchez-Moreno, Carmen Monsalve-Hernando, Ana Godino, Luis Illa, María Jesús Gaspar, Guillermo Manuel Muñoz, Ana Díaz, José Luis Martín, Eduardo García-Junceda, Alfonso Fernández-Mayoralas, Carmen Hermida
Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates that a new enzymatic xylose quantification method, based on the activity of xylose dehydrogenase from Caulobacter crescentus, represents an excellent alternative to the manual phloroglucinol reaction...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29131778/adventures-and-misadventures-in-plastic-surgery-and-soft-tissue-implants
#3
Dana J Lin, Tony T Wong, Gina A Ciavarra, Jonathan K Kazam
Soft-tissue augmentation and implants are increasingly seen by the radiologist as more techniques emerge for a variety of indications and locations. Some surgical and implant procedures are performed for purely cosmetic reasons in otherwise healthy patients seeking to improve their body image, and some are performed for reconstruction after cancer or other chronic illnesses. Abdominoplasty, liposuction, and autologous fat grafting can be performed for abdominal and gluteal contouring. Injection of liquid injectable silicone has historically been fraught with legal issues, although it continues to be used for augmentation in a variety of anatomic locations...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29126109/do-prospective-payment-systems-ppss-lead-to-desirable-providers-incentives-and-patients-outcomes-a-systematic-review-of-evidence-from-developing-countries
#4
Si Ying Tan, G J Melendez-Torres
The reform of provider payment systems, from retrospective to prospective payment, has been heralded as the right move to contain costs in the light of rising health expenditures in many countries. However, there are concerns on quality trade-off. The heightened attention given to prospective payment system (PPS) reforms and the rise of empirical evidence regarding PPS interventions among developing countries suggest that a systematic review is necessary to understand the effects of PPS reforms in developing countries...
November 6, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29110689/multicriteria-plan-optimization-in-the-hands-of-physicians-a-pilot-study-in-prostate-cancer-and-brain-tumors
#5
Birgit S Müller, Helen A Shih, Jason A Efstathiou, Thomas Bortfeld, David Craft
BACKGROUND: The purpose of this study was to demonstrate the feasibility of physician driven planning in intensity modulated radiotherapy (IMRT) with a multicriteria optimization (MCO) treatment planning system and template based plan optimization. Exploiting the full planning potential of MCO navigation, this alternative planning approach intends to improve planning efficiency and individual plan quality. METHODS: Planning was retrospectively performed on 12 brain tumor and 10 post-prostatectomy prostate patients previously treated with MCO-IMRT...
November 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29104835/online-adaptive-radiation-therapy-implementation-of-a-new-process-of-care
#6
James Lamb, Minsong Cao, Amar Kishan, Nzhde Agazaryan, David H Thomas, Narek Shaverdian, Yingli Yang, Suzette Ray, Daniel A Low, Ann Raldow, Michael L Steinberg, Percy Lee
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers in the world. This technology has facilitated the clinical implementation of online adaptive radiotherapy (OART), or the ability to alter the daily treatment plan based on tumor and anatomical changes in real-time while the patient is on the treatment table. However, due to the time sensitive nature of OART, implementation in a large and busy clinic has many potential obstacles as well as patient-related safety considerations...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29102478/reliability-validity-and-minimal-detectable-change-of-the-push-off-test-scores-in-assessing-upper-extremity-weight-bearing-ability
#7
Saurabh P Mehta, Hannah R George, Christian A Goering, Danielle R Shafer, Alan Koester, Steven Novotny
STUDY DESIGN: Clinical measurement study. INTRODUCTION: The push-off test (POT) was recently conceived and found to be reliable and valid for assessing weight bearing through injured wrist or elbow. However, further research with larger sample can lend credence to the preliminary findings supporting the use of the POT. PURPOSE OF THE STUDY: This study examined the interrater reliability, construct validity, and measurement error for the POT in patients with wrist conditions...
November 1, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29101141/incidence-of-patient-safety-events-and-process-related-human-failures-during-intra-hospital-transportation-of-patients-retrospective-exploration-from-the-institutional-incident-reporting-system
#8
Shu-Hui Yang, Jih-Shuin Jerng, Li-Chin Chen, Yu-Tsu Li, Hsiao-Fang Huang, Chao-Ling Wu, Jing-Yuan Chan, Szu-Fen Huang, Huey-Wen Liang, Jui-Sheng Sun
BACKGROUND: Intra-hospital transportation (IHT) might compromise patient safety because of different care settings and higher demand on the human operation. Reports regarding the incidence of IHT-related patient safety events and human failures remain limited. OBJECTIVE: To perform a retrospective analysis of IHT-related events, human failures and unsafe acts. SETTING: A hospital-wide process for the IHT and database from the incident reporting system in a medical centre in Taiwan...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29082462/low-level-laser-therapy-with-940%C3%A2-nm-diode-laser-on-stability-of-dental-implants-a-randomized-controlled-clinical-trial
#9
Parviz Torkzaban, Shahin Kasraei, Sara Torabi, Maryam Farhadian
Low-level laser therapy (LLLT) is a non-invasive modality to promote osteoblastic activity and tissue healing. The aim of this study was to evaluate the efficacy of LLLT for improvement of dental implant stability. This randomized controlled clinical trial was performed on 80 dental implants placed in 19 patients. Implants were randomly divided into two groups (n = 40). Seven sessions of LLLT (940 nm diode laser) were scheduled for the test group implants during 2 weeks. Laser was irradiated to the buccal and palatal sides...
October 29, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29043142/costimulation-pathway-blockade-in-kidney-transplant-recipients-with-de-novo-rheumatoid-arthritis
#10
Mohamed Sheta, Samy Riad, Udayakumar Deepak, Naim Issa, Mark Birkenbach, Hassan N Ibrahim, Aleksandra Kukla
The best approach to treatment of de-novo rheumatoid arthritis in solid organ transplant recipients on typical immunosuppression is not well established. The use of biologics targeting specific cell types, cytokines, and immunological pathways has been gaining interest in the treatment of both, auto- and alloimmunity. We present a case of de-novo rheumatoid arthritis in a kidney transplant recipient 10 years post-transplant while receiving cyclosporine, mycophenolate mofetil, and also prednisone. Initial presentation included features of polymyalgia rheumatica and nephrotic range proteinuria...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/28985717/identification-of-vps35-p-d620n-mutation-related-parkinson-s-disease-in-a-taiwanese-family-with-successful-bilateral-subthalamic-nucleus-deep-brain-stimulation-a-case-report-and-literature-review
#11
Ying-Fa Chen, Yung-Yee Chang, Min-Yu Lan, Pei-Lung Chen, Chin-Hsien Lin
BACKGROUND: Vacuolar protein sorting 35 (VPS35) was recently reported to be a genetic cause for late-onset autosomal dominant Parkinson's disease (PD). However, VPS35 mutations are rarely reported in Asian populations. Herein, we report the first Taiwanese family with the pathogenic VPS35 p.D620N mutation, including one patient treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS). CASE PRESENTATION: A 61-year-old woman presented with progressive left hand resting tremor at the age of 42...
October 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28950843/a-new-clinical-test-for-sensorimotor-function-of-the-hand-development-and-preliminary-validation
#12
Ulrik Röijezon, Ragnar Faleij, Petros Karvelis, George Georgoulas, George Nikolakopoulos
BACKGROUND: Sensorimotor disturbances of the hand such as altered neuromuscular control and reduced proprioception have been reported for various musculoskeletal disorders. This can have major impact on daily activities such as dressing, cooking and manual work, especially when involving high demands on precision and therefore needs to be considered in the assessment and rehabilitation of hand disorders. There is however a lack of feasible and accurate objective methods for the assessment of movement behavior, including proprioception tests, of the hand in the clinic today...
September 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28944966/inpatient-management-of-children-with-recessive-dystrophic-epidermolysis-bullosa-a-review
#13
REVIEW
Alvin W Li, Brea Prindaville, Scot T Bateman, Timothy E Gibson, Karen Wiss
Recessive dystrophic epidermolysis bullosa is a disorder marked by skin and mucosal blistering after minimal trauma. Even the most routine procedures in the hospital, if done incorrectly, can precipitate extensive skin loss, pain, and scarring. Most providers have little experience working with patients with this degree of skin fragility. When a person with recessive dystrophic epidermolysis bullosa is admitted to the hospital, there are multiple considerations to keep in mind while strategizing an effective care plan: avoidance of new blisters with a "hands-off" approach; careful consideration of all indwelling devices; symptomatic management of pain, itch, and anxiety; coordination of dressing changes; aggressive treatment of skin infections; environmental and staffing considerations; and awareness of other chronic complications that affect care, such as anemia, malnutrition, and chronic pain...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28932966/regorafenib-in-advanced-hepatocellular-carcinoma-hcc-considerations-for-treatment
#14
Kyung Kim, Reena Jha, Petra A Prins, Hongkun Wang, Monica Chacha, Marion L Hartley, Aiwu Ruth He
PURPOSE: We report our institutional observations of ten patients with advanced hepatocellular carcinoma (HCC) (seven and three were Child-Pugh class A and B, respectively) who received compassionate regorafenib therapy between June 2016 and January 2017. These patients did not fit the rigid criteria of a clinical trial and represented the use of regorafenib in an everyday clinic situation. METHODS: Regorafenib (160 mg P.O. daily) was administered to patients on a 4-week cycle (3 weeks on, 1 week off) until disease progression (assessed using mRECIST criteria) or discontinuation secondary to toxicity (assessed using CTCAE criteria)...
September 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28932486/-on-track-and-off-track-shoulder-lesions
#15
REVIEW
E Itoi
Shoulder stability depends on the position of the arm as well as activities of the muscles around the shoulder. The capsulo-ligamentous structures are the main stabilisers with the arm at the end-range of movement, whereas negative intra-articular pressure and concavity-compression effect are the main stabilisers with the arm in the mid-range of movement.There are two types of glenoid bone loss: fragment type and erosion type. A bone loss of the humeral head, known as a Hill-Sachs lesion (HSL), is a compression fracture of the humeral head caused by the anterior rim of the glenoid when the humeral head is dislocated anteriorly in front of the glenoid...
August 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28922169/app-based-bradykinesia-tasks-for-clinic-and-home-assessment-in-parkinson-s-disease-reliability-and-responsiveness
#16
Dustin A Heldman, Enrique Urrea-Mendoza, Lilia C Lovera, David A Schmerler, Xiomara Garcia, Mohammad E Mohammad, Maria Catalina U McFarlane, Joseph P Giuffrida, Alberto J Espay, Hubert H Fernandez
BACKGROUND: Clinical rating of bradykinesia in Parkinson disease (PD) is challenging as it must combine several movement features into a single score. Additionally, in-clinic assessment cannot capture fluctuations throughout the day. OBJECTIVE: To evaluate the reliability and responsiveness of a motion sensor-based tablet app for objective bradykinesia assessment in clinic and at home as compared to clinical ratings. METHODS: Thirty-two PD patients treated with subthalamic deep brain stimulation (DBS) were outfitted with a motion sensor on the index finger of the more affected hand to perform two repetitions of finger-tapping, hand opening-closing, and arm pronation-supination tasks with DBS on and 10, 20, and 30 minutes after turning DBS off...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28917388/improvised-hand-injury-treatment-using-traditional-veterinary-medicine-in-ethiopia
#17
Raf Aerts, Eva J J November, Maissa Rayyan
In remote wilderness environments, local people with traditional knowledge of medicinal plants are potentially important first-line health care providers. We present a case of a 31-year-old man who fell off a horse while trekking through a remote mountain landscape in Ethiopia and sustained blunt force trauma to the hand. A local mountain hut keeper examined the patient's hand and used heated leaves of the succulent plant Kalanchoe petitiana to treat a suspected metacarpal fracture. As first responder in a low-resource setting, the hut keeper relied on his traditional knowledge of ethnoveterinary medicine to improvise a treatment for a human injury in a remote mountain environment...
September 13, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28915580/molecular-and-functional-characterization-of-a-new-3-end-kit-juxtamembrane-deletion-in-a-duodenal-gist-treated-with-neoadjuvant-imatinib
#18
Vittorio Perfetti, Erik Laurini, Suzana Aulić, Maurizio Fermeglia, Roberta Riboni, Marco Lucioni, Elena Dallera, Sara Delfanti, Luigi Pugliese, Francesco Saverio Latteri, Andrea Pietrabissa, Sabrina Pricl
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs express the receptor tyrosine kinase KIT, and the majority of GISTs present KIT gain-of-function mutations that cluster in the 5' end of the receptor juxtamembrane domain. On the other hand, little information is known about GISTs carrying mutations in the 3' end of the KIT juxtamembrane domain. Here we report and discuss a clinical case of localized duodenal GIST whose molecular characterization revealed the presence of a new 21 nucleotide/7 amino acid deletion in the 3' end of KIT juxtamembrane domain (Δ574-580)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902098/repair-of-the-thumb-ulnar-collateral-ligament-with-suture-tape-augmentation
#19
Anthony F De Giacomo, Steven S Shin
One of the most commonly injured structures of the thumb metacarpophalangeal (MCP) joint is the ulnar collateral ligament (UCL). An acute injury of this ligament is often amenable to primary repair. Despite the favorable outcomes of primary repair, the thumb is often restricted during initial healing of the ligament with immobilization and delayed rehabilitation. We present a novel technique to augment the repair of the UCL with suture tape to provide immediate biomechanical support and strength during the critical time of ligament healing...
December 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28900068/-efficacy-of-topical-agents-for-symptomatic-treatment-of-rotigotine-patch-induced-skin-disorders
#20
Yuki Yasutaka, Shinsuke Fujioka, Hirotomo Shibaguchi, Fumiaki Kiyomi, Koyomi Hara, Kentaro Ogata, Yoshio Tsuboi, Hidetoshi Kamimura
Since the effect of a percutaneous absorption-type dopamine agonist (DA) preparation, rotigotine patch, stably persists by once-a-day application, this dosage form is appropriate for Parkinson's disease patients showing levodopa induced wearing off phenomenon. On the other hand, skin disorders, mainly application site reaction, are characteristic problems associated with use of the patch. In this study, to clarify the influence of a topical agent used to prevent or treat rotigotine patch-induced skin disorder on continuation of the patch application, patients who started rotigotine patch application at our hospital were retrospectively surveyed...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
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