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https://www.readbyqxmd.com/read/29766126/factor-viia-administration-in-traumatic-brain-injury-an-aast-mitc-propensity-score-analysis
#1
Sarah Lombardo, D Millar, Gregory J Jurkovich, Raul Coimbra, Ram Nirula
Background: Recombinant factor VIIa (rFVIIa) has been used off-label as an adjunct in the reversal of warfarin therapy and management of hemorrhage after trauma. Only a handful of these reports are rigorous studies, from which results regarding safety and effectiveness have been mixed. There remains no clear consensus as to the role of rFVIIa in traumatic brain injury (TBI). Methods: Eleven level 1 trauma centers provided clinical data and head CT scans of patients with a Glasgow Coma Scale (GCS) score of ≤13 and radiographic evidence of TBI...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29761877/diagnostic-accuracy-of-new-and-old-cognitive-screening-tools-for-hiv-associated-neurocognitive-disorders
#2
M Trunfio, D Vai, C Montrucchio, C Alcantarini, A Livelli, M C Tettoni, G Orofino, S Audagnotto, D Imperiale, S Bonora, G Di Perri, A Calcagno
OBJECTIVES: Considering the similarities between HIV-associated neurocognitive disorders (HAND) and neurodegenerative dementias and the frequency of executive dysfunctions among HIV-positive patients, we evaluated the accuracy of the Frontal Assessment Battery and Clock-Drawing Test together with the Three Questions Test and International HIV Dementia Scale to screen for HAND. METHODS: A cross-sectional monocentric study was conducted from 2010 to 2017. The index tests were represented by the four screening tools; the reference standard was represented by a comprehensive neurocognitive battery used to investigate 10 cognitive domains...
May 15, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29753276/impaction-of-swallowed-dentures-in-the-sigmoid-colon-requiring-sigmoid-colectomy
#3
Michael Flanagan, Cillian Clancy, Micheal G O Riordain
INTRODUCTION: Foreign body (FB) ingestion results in perforation in 1% of cases and is associated with significant morbidity and rarely mortality. Clinical presentation is variable and can present a diagnostic challenge. We report our experience and management of a patient with a delayed presentation of a sigmoid colon foreign body as a result of ingestion of a dental plate. PRESENTATION OF CASE: A 67 year old female attended the colorectal outpatient clinic following an incidental finding of a sigmoid mass on computed tomography (CT) abdomen...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29730963/screening-for-intellectual-disabilities-a-validation-of-the-hayes-ability-screening-index-for-in-patients-with-substance-use-disorder
#4
Kirsten J Braatveit, Torbjørn Torsheim, Oddbjørn Hove
BACKGROUND: There is a reason to believe that many individuals with substance use disorder (SUD) in contact with services have an undiagnosed intellectual disability (ID). Assessing ID in persons with SUD can be challenging due to the influence of substances, time consumption, and specific requirements for the education of the assessor. On the other hand, an undiagnosed condition may lead to a lack of treatment adjustment and may result in drop-out from treatment or lack of treatment effect...
May 7, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29706412/handover-from-operating-theatre-to-the-intensive-care-unit-a-quality-improvement-study
#5
Andrea P Marshall, Georgia Tobiano, Niki Murphy, Greg Comadira, Nicola Willis, Therese Gardiner, Lucy Hervey, Wendy Simpson, Brigid M Gillespie
BACKGROUND: Transitioning a patient from the operating theatre (OT) to the intensive care unit (ICU) is a dynamic and complex process. Handover of the critically ill postoperative patient can contribute to procedural and communication errors. Standardised protocols are means for structuring and improving handover content. Both have been shown to be effective in reducing information omission and improve communication during this transition period. OBJECTIVES: The aim of this uncontrolled before and after study was to improve handover processes and communication about the care for critically ill patients transferred from OT to ICU...
April 26, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29689575/investigating-patients-perception-of-microvascular-free-toe-flap-for-reconstruction-of-amputated-thumbs-a-guide-for-surgeons-during-informed-consent
#6
Johnny Ionut Efanov, Christopher Wong, Clarence Guilbault, Joseph Bou-Merhi, Patrick G Harris, Ali Izadpanah, Michel Alain Danino
BACKGROUND:  After thumb amputations, restoration of function and aesthetic can be accomplished with microvascular free toe flaps. However, many patients in clinical practice do not choose this reconstruction despite positive reported outcomes. This study aims to determine patients' perceptions with respect to free toe flaps to improve areas of informed consent. METHODS:  A retrospective survey was administered to patients with thumb amputations. Participants were required to complete a questionnaire about patient demographics, the Brief Michigan Hand Questionnaire (bMHQ), the standard gamble/time trade-off questionnaires for utility scores, and a questionnaire investigating potential reasons for electing not to undergo a free toe transfer...
April 24, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29683088/increase-in-skin-perfusion-pressure-predicts-amputation-free-survival-after-lower-extremity-bypass-surgery-for-critical-limb-ischemia
#7
Kota Yamamoto, Takuya Kawahara, Atsushi Akai, Toshihiko Isaji, Daisuke Akagi, Takuya Miyahara, Katsuyuki Hoshina
The objective of this study was to determine how postoperative skin perfusion pressure (SPP) as a measure of blood flow after revascularization affects limb prognosis in patients with critical limb ischemia (CLI). We retrospectively reviewed 223 consecutive bypass surgery cases performed in 192 patients with CLI during a 10-year period. SPP was measured 1-2 weeks before and after the procedure. An SPP of 40 mmHg was set as the cut-off value for revascularization. Patients were grouped according to their postoperative SPPs, and amputation-free survival (AFS) was analyzed...
April 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29679170/light-localization-with-low-contrast-targets-in-a-patient-implanted-with-a-suprachoroidal-transretinal-stimulation-retinal-prosthesis
#8
Takao Endo, Takashi Fujikado, Masakazu Hirota, Hiroyuki Kanda, Takeshi Morimoto, Kohji Nishida
PURPOSE: To evaluate the improvement in targeted reaching movements toward targets of various contrasts in a patient implanted with a suprachoroidal-transretinal stimulation (STS) retinal prosthesis. METHODS: An STS retinal prosthesis was implanted in the right eye of a 42-year-old man with advanced Stargardt disease (visual acuity: right eye, light perception; left eye, hand motion). In localization tests during the 1-year follow-up period, the patient attempted to touch the center of a white square target (visual angle, 10°; contrast, 96, 85, or 74%) displayed at a random position on a monitor...
April 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29672526/structured-patient-handoff-on-an-internal-medicine-ward-a-cluster-randomized-control-trial
#9
Penny Tam, Aman P Nijjar, Mark Fok, Chris Little, Alexandra Shingina, Jesse Bittman, Rashmi Raghavan, Nadia A Khan
BACKGROUND: The effect of a multi-faceted handoff strategy in a high volume internal medicine inpatient setting on process and patient outcomes has not been clearly established. We set out to determine if a multi-faceted handoff intervention consisting of education, standardized handoff procedures, including fixed time and location for face-to-face handoff would result in improved rates of handoff compared with usual practice. We also evaluated resident satisfaction, health resource utilization and clinical outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29670781/-candida-krusei-empyema-thoracis-a-community-acquired-infection-requiring-a-high-index-of-suspicion
#10
Hazim Bukamur, Waseem Ahmed, Yazan Numan, Ibrahim Shahoub, Fuad Zeid
Empyema thoracis is a serious condition characterized by the accumulation of purulent fluid in the pleural cavity, typically following a pneumonia, subdiaphragmatic abscess, or esophageal rupture. Fungal empyema thoracis is a rare form of this condition with especially high mortality, in which the most frequently isolated fungus is Candida spp. This article presents a 74-year-old female with Candida krusei pneumonia and a complicated hospital course, initially presenting with nausea, vomiting, and dysphagia...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29665258/health-related-quality-of-life-and-fall-risk-associated-with-age-related-body-composition-changes-sarcopenia-obesity-and-sarcopenic-obesity
#11
Zeynel Abidin Öztürk, İbrahim Halil Türkbeyler, Azer Abiyev, Seval Kul, Bahadır Edizer, Funda Datli Yakaryılmaz, Gülçimen Soylu
BACKGROUND: Sarcopenia, obesity, and sarcopenic obesity are various features of the aging process that can cause important health issues. The present study was undertaken to investigate the interrelationship between those body composition changes including their clinical components and the quality of life variables. METHODS: 423 individuals aged 65 years or more were included in this cross-sectional study. Sarcopenia was diagnosed according to The European Working Group on Sarcopenia in Older People criteria...
April 17, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29661068/correlation-between-radiological-parameters-and-functional-outcomes-in-patients-older-than-60-years-of-age-with-distal-radius-fracture
#12
Rodrigo Gutiérrez-Monclus, Héctor Gutiérrez-Espinoza, Jonathan Zavala-González, Cristian Olguín-Huerta, David Rubio-Oyarzún, Felipe Araya-Quintanilla
BACKGROUND: The relationship between radiographic and functional outcomes is controversial in the elderly. The objective of this study is to determine whether there is a correlation between functional outcome and acceptable distal radius fracture (DRF) alignment in patients older than 60 years of age. METHODS: This correlation study was carried out at the Central Metropolitan Health Service of Chile. A total of 180 patients diagnosed with extra-articular DRF, according to the AO classification, were prospectively recruited...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29660262/reactive-periostitis-from-inhalant-abuse
#13
Lauren E Hock, Iiro Honkanen, Wendy Fiordellisi, Brittany Bettendorf
The patient, a 36-year-old woman, presented with a 6-week history of swollen hands and fingers and associated arthralgia. She had a history of polysubstance abuse. The arthralgia and swelling started one month after she began inhaling two cans of "Dust-Off" (1,1-difluoroethane) daily. Physical examination revealed tender proximal and middle phalanges of all fingers bilaterally with bulbous appearance (A). There was no clubbing. Radiography of the hands revealed diffuse reactive periostitis with discrete layering of periosteal bone formation without bony destruction (B)...
April 16, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29624617/reference-values-for-hand-grip-strength-in-the-south-korean-population
#14
Chung Reen Kim, Young-Jee Jeon, Moon Chan Kim, Taeheum Jeong, Woo Ram Koo
OBJECTIVE: To establish reference values for hand grip strength (HGS) in a healthy Korean population and to identify the dependent anthropometric variables that affect HGS. METHODS: Based on the sixth Korea National Health and Nutrition Examination Survey from 2014 to 2015, we analyzed the HGS data of 7,969 South Koreans. Individuals with specific chronic diseases and who reported poor subjective health status were excluded to ensure a healthy population sample...
2018: PloS One
https://www.readbyqxmd.com/read/29624596/embodied-pain-in-fibromyalgia-disturbed-somatorepresentations-and-increased-plasticity-of-the-body-schema
#15
Endika Martínez, Zigor Aira, Itsaso Buesa, Ibane Aizpurua, Diego Rada, Jon Jatsu Azkue
Fibromyalgia syndrome (FMS) is a highly prevalent, chronic musculoskeletal condition characterized by widespread pain and evoked pain at tender points. This study evaluated various aspects of body awareness in a sample of 14 women with FMS and 13 healthy controls, such as plasticity of the body schema, body esteem, and interoceptive awareness. To this end, the Rubber Hand Illusion (RHI), the Body Esteem Scale (BES), and the Body Perception Questionnaire (BPQ) were used, respectively. Consistent with increased plasticity of the body schema, FMS patients scored higher, with large or very large effect sizes, across all three domains evaluated in the RHI paradigm, namely proprioceptive drift and perceived ownership and motor control over the rubber hand...
2018: PloS One
https://www.readbyqxmd.com/read/29622909/anemia-among-hiv-infected-individuals-taking-art-with-and-without-zidovudine-at-addis-ababa-ethiopia
#16
Zemenu Tamir, Jemal Alemu, Aster Tsegaye
Background: Hematological complications such as Zidovudine(ZDV) associated anemia are among the commonly reported adverse drug reactions of Antiretroviral Therapy(ART). Little is known about ZDV associated anemia in developing countries like Ethiopia. Methods: Comparative retrospective cohort study was conducted at the ART Clinic of St. Paul Hospital Millennium Medical College from February 2011 to December 2012 to characterize anemia among HIV/AIDS patients initiated with ZDV and non-ZDV containing ART regimens...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29622435/reactive-hyperemia-peripheral-arterial-tonometry-is-useful-for-assessment-of-not-only-endothelial-function-but-also-stenosis-of-the-digital-artery
#17
Shinji Kishimoto, Takeshi Matsumoto, Tatsuya Maruhashi, Yumiko Iwamoto, Masato Kajikawa, Nozomu Oda, Shogo Matsui, Haruki Hashimoto, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Farina Binti Mohamad Yusoff, Ayumu Nakashima, Kensuke Noma, Yukihito Higashi
BACKGROUND: Although reactive hyperemia-peripheral arterial tonometry (RH-PAT) is widely used for assessment of endothelial function, RH index (RHI) cannot be measured in some cases when pulse wave amplitude (PWA) is very low. Decrease in PWA is mainly caused by proper palmar digital artery (PPDA) stenosis. The purpose of this study was to evaluate the relationship between PWA measured by RH-PAT and stenosis of the PPDA measured by digital subtraction angiography and to evaluate the limitation of assessment of endothelial function measured by RHI in patients with PPDA stenosis...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29615901/isoquercetin-as-an-adjunct-therapy-in-patients-with-kidney-cancer-receiving-first-line-sunitinib-quasar-results-of-a-phase-i-trial
#18
Carlo Buonerba, Pietro De Placido, Dario Bruzzese, Martina Pagliuca, Paola Ungaro, Davide Bosso, Dario Ribera, Simona Iaccarino, Luca Scafuri, Antonietta Liotti, Valeria Romeo, Michela Izzo, Francesco Perri, Beniamino Casale, Giuseppe Grimaldi, Francesca Vitrone, Arturo Brunetti, Daniela Terracciano, Alfredo Marinelli, Sabino De Placido, Giuseppe Di Lorenzo
Sunitinib is the most commonly prescribed drug for advanced renal cell carcinoma in the first-line setting and has been associated with multiple adverse events related to its on-and off-target effects, including hand and foot syndrome and fatigue. It was hypothesized that sunitinib-induced fatigue may be related to off target inhibition of the AMPK enzyme, which results in impairment of energy-producing processes at a systemic level. Quercetin is a naturally occurring flavonol with established AMPK-stimulating activity...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29607820/assessment-of-sunitinib-alternative-prescription-schedules-in-metastatic-kidney-cancer-a-study-of-10-cases
#19
Habib Diallo, Hasnae Alaoui Mhamdi, Salma Elouarzazi, Mohamed Fadli, Rhizlane Belbaraka
BACKGROUND: Managing metastatic Renal Cell Carcinoma (mRCC) has been revolutionized during the first decade of the 21st century due to the development of targeted therapies. The sunitinib is an oral multi-targeted receptor Tyrosine Kinase Inhibitor (TKI). It became the first targeted therapy as first-line treatment to improve the survival of patients with metastatic kidney cancer. This treatment consists in the oral intake of 50 mg of sunitinib per day in a 6 -week cycle including 4 weeks of treatment intake (the "on" week) followed by a 2-week break (the off week)...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29599670/dermoscopic-assessment-of-skin-toxicities-in-patients-with-melanoma-during-treatment-with-vemurafenib
#20
Marcin Rajczykowski, Grazyna Kaminska-Winciorek, Elzbieta Nowara, Marzenna Samborska-Plewicka, Sebastian Giebel
Introduction: The use of vemurafenib in melanoma has improved the survival of patients; however, it is associated with skin toxicities. Aim: To assess skin toxicities by dermoscopy in patients treated with vemurafenib. Material and methods: Eight patients with BRAF V600 mutation positive metastatic melanoma were examined dermoscopically during vemurafenib treatment. All skin lesions occurring during therapy were assessed clinically and dermoscopically using a hand-held dermoscope with polarised and non-polarised light...
February 2018: Postȩpy Dermatologii i Alergologii
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