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https://www.readbyqxmd.com/read/28718309/intra-articular-fracture-of-the-base-of-the-first-metacarpal-bone-treatment-through-a-volar-approach
#1
Violeta Levy, Marcelo Mazzola, Martín Gonzalez
BACKGROUND: Management of Bennett fractures has been controversial. Early reports supported closed reduction and casting with or without percutaneous pinning. Later, open reduction and internal fixation was advocated. The purpose of this article is to assess the surgical treatment using a direct volar approach. METHODS: Between March 2008 and December 2014, 21 patients with intra-articular first metacarpal fractures displaced more than 1 mm were operated on using a direct volar approach...
January 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28701947/protein-restricted-diets-for-ameliorating-motor-fluctuations-in-parkinson-s-disease
#2
REVIEW
Luxi Wang, Nian Xiong, Jinsha Huang, Shiyi Guo, Ling Liu, Chao Han, Guoxin Zhang, Haiyang Jiang, Kai Ma, Yun Xia, Xiaoyun Xu, Jie Li, Jing Y Liu, Tao Wang
Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable "on-off"). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet (LPD), protein-redistribution diet (PRD) and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28700123/nonlinear-analysis-to-detect-if-excellent-nursing-work-environments-have-highest-well-being
#3
Giuseppe Casalicchio, Emmanuel Lesaffre, Helmut Küchenhoff, Luk Bruyneel
PURPOSE: To detect potentially nonlinear associations between nurses' work environment and nurse staffing on the one hand and nurse burnout on the other hand. DESIGN: A cross-sectional multicountry study for which data collection using a survey of 33,731 registered nurses in 12 European countries took place during 2009 to 2010. METHODS: A semiparametric latent variable model that describes both linear and potentially nonlinear associations between burnout (Maslach Burnout Inventory: emotional exhaustion, depersonalization, personal accomplishment) and work environment (Practice Environment Scale of the Nursing Work Index: managerial support for nursing, doctor-nurse collegial relations, promotion of care quality) and staffing (patient-to-nurse ratio)...
July 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28696336/perspectives-on-exhaled-nitric-oxide
#4
Fabio Luigi Massimo Ricciardolo, Philip E Silkoff
The history of nitric oxide (NO) in respiratory field dates back to the beginning of '90s with the ancestral study by Lars Gustafsson et al. describing the presence of endogenous NO in the exhaled breath of human beings. Soon after, independent studies showed that exhaled NO concentrations (FENO) is higher in asthmatics than in normal subjects. Not all asthmatics demonstrate a high FENO reflecting heterogeneity of asthma. High values of FENO are associated with over-expression of corticosteroid-sensitive iNOS isoform and allergic/eosinophilic inflammation...
July 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28694679/a-clinical-perspective-on-a-pain-neuroscience-education-approach-to-manual-therapy
#5
Adriaan Louw, Jo Nijs, Emilio J Puentedura
In recent years, there has been an increased interest in pain neuroscience education (PNE) in physical therapy. There is growing evidence for the efficacy of PNE to decrease pain, disability, fear-avoidance, pain catastrophization, limited movement, and health care utilization in people struggling with pain. PNE teaches people in pain more about the biology and physiology of their pain experience including processes such as central sensitization, peripheral sensitization, allodynia, inhibition, facilitation, neuroplasticity and more...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28691973/a-swift-method-for-handing-off-obstetrical-patients-on-the-labor-floor
#6
Jean-Ju Sheen, Laura Reimers, Shravya Govindappagari, Ivan M Ngai, Diana Garretto, Roopali Donepudi, Pamela Tropper, Dena Goffman, Ashlesha K Dayal, Peter S Bernstein
OBJECTIVE: The aim of this study was to improve patient handoffs on the labor floor. METHODS: A prospective cohort study of obstetrics residents at Montefiore Medical Center was performed between 2012 and 2014. Labor-floor handoffs were recorded before and after didactic sessions as well as after installation of whiteboards formatted with the mnemonic SWIFT (Subject, Why?, Issues, Fetus, Tasks). Handoff transcripts were evaluated by obstetricians blinded to timing and speaker identity...
July 6, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28689958/one-stage-endovascular-treatment-of-a-symptomatic-penetrating-ulcer-in-the-lusorian-artery-and-an-aaa-a-challenging-case-in-a-rare-entity
#7
Mirko Esche, Pavel Sebesta, Sven Seifert
INTRODUCTION: We report a case of a 57-year old man with a successful total endovascular treatment of a symptomatic penetrating arterial ulcer (PAU) of a lusorian artery together with a standard endovascular abdominal aortic aneurysm (AAA) repair. The lusorian artery is an aberrant subclavian artery and a congenital aortic arch anomaly with a reported prevalence of 0.4 to 2.6 %. Typical for the base of the lusorian artery is a Kommerell diverticulum making an endovascular approach even more difficult...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28689707/any-questions-yes-do-pharmacists-monitor-medications-at-refill
#8
Matthew J Witry, Lisa M Guirguis
OBJECTIVES: To describe pharmacists' self-reported refill monitoring activities and test for demographic and work setting differences that contribute to variation. METHODS: This study used a cross-sectional survey design. A 4-contact survey was mailed to 599 community pharmacists randomly selected from a list provided by the state board of pharmacy. Surveys were mailed in June and July 2013. Descriptive statistics and analysis of variance were used to characterize these data...
July 6, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28687627/phase-ii-trial-of-sorafenib-in-combination-with-capecitabine-in-patients-with-hepatocellular-carcinoma-inst-08-20
#9
Yehuda Patt, Cristhiam Rojas-Hernandez, Houman Mohammad Fekrazad, Pranshu Bansal, Fa Chyi Lee
LESSONS LEARNED: There continues to be a lack of systemic options for advanced hepatocellular carcinoma (HCC); sorafenib and, very recently, regorafenib are the only approved options. There exists a potential to combine sorafenib with chemotherapeutic agents shown to be active in HCC, such as capecitabine, safely.Good tumor response was observed, with objective improvement in a few patients seldom seen by single agent sorafenib; however, because of the limited number of patients, meaningful conclusions on survival cannot be drawn...
July 7, 2017: Oncologist
https://www.readbyqxmd.com/read/28683237/late-night-salivary-cortisol-is-unaltered-in-patients-with-polycystic-ovarian-syndrome-pcos-irrespective-of-disease-phenotype-and-in-obese-women-irrespective-of-the-presence-of-pcos
#10
Hande Mefkure Ozkaya, Fatma Ela Keskin, Abdullah Tuten, Ebru Korkmaz, Hulya Zeynep Oktay, Pinar Kadioglu
OBJECTIVE: To determine cut-off values of late-night salivary cortisol (LNSC) using an electrochemiluminescent immunoassay (ECLIA) and to investigate whether the diagnostic performance of the assay was influenced by the presence of obesity or polycystic ovary syndrome (PCOS). METHODS: A total of 124 subjects comprising 25 patients with Cushing's syndrome (CS), 44 with PCOS (22 nonobese and 22 obese), 21 with constitutional obesity (CO), and 34 healthy subjects (HS) were included in the study...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28681161/functional-and-cosmetic-outcome-of-single-digit-ray-amputation-in-hand
#11
A K Bhat, A M Acharya, J K Narayanakurup, B Kumar, P S Nagpal, A Kamath
PURPOSE: To assess patient satisfaction, functional and cosmetic outcomes of single-digit ray amputation in hand and identify factors that might affect the outcome. METHODS: Forty-five patients who underwent ray amputation were evaluated, 37 males and eight females whose mean age was 36.6 years ranging between 15 and 67 years. Twenty-eight patients had dominant hand involvement. Twenty-one patients underwent primary ray amputation, and 24 patients had secondary ray amputation...
July 5, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28671144/a-novel-p-glu298lys-mutation-in-the-acmsd-gene-in-sporadic-parkinson-s-disease
#12
Dolores Vilas, Rubén Fernández-Santiago, Elena Sanchez-Rodriguez, Luis J Azcona, Meritxell Santos-Montes, Pilar Casquero, Lucía Argandoña, Eduardo Tolosa, Coro Paisán-Ruiz
Common genetic variability in the ACMSD gene has been associated with increased risk for Parkinson's disease (PD) but ACMSD mutations in clinical cases of PD have so far not been described. We report a 74-year-old man with sporadic PD who developed tremor in his right hand and slowness. On examination, moderate rigidity, asymmetric bradykinesia, and bilateral action tremor were present. He was started on levodopa with significant improvement. Two years later, he developed wearing off phenomena. The genetic study in the patient identified a novel ACMSD mutation resulting in p...
June 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28670882/circulating-hypermethylated-rassf1a-as-a-molecular-biomarker-for-diagnosis-of-hepatocellular-carcinoma
#13
Lamiaa A Mansour, Maissa El Raziky, Amal A Mohamed, Enas H Mahmoud, Sherif Hamdy, Enas H El Sayed
Background: Detection of circulating DNA can be applied for the diagnosis of many malignant neoplasms, including the hepatocellular carcinoma (HCC). The molecular pathogenesis of HCC is complex, involving different genetic and epigenetic alterations, chromosomal aberrations, gene mutations and altered molecular pathways. RASSF1A is a well-established tumor suppressor gene which suffers frequent inactivation due to promoter hypermethylation of CPG islands in multiple tumors including HCC, resulting in the reduction or loss of gene expression...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28652791/off-label-drugs-for-weight-management
#14
REVIEW
Ed J Hendricks
The global pandemic of obesity and overweight now affects between 2.8 and 3.5 billion of the world population and shows no signs of abatement. Treatment for what is now recognized as a chronic disease includes pharmacotherapy, considered an essential component of comprehensive therapy. New drug discovery is robust, but the pace of the US Food and Drug Administration approval for obesity drugs has been glacial, and only a handful of approved drugs are available for treating obesity. In the last 20 years, the US Food and Drug Administration has approved 208 drugs for cancer, 118 for cardiovascular diseases, 168 for neurological diseases, and 223 endocrinologic drugs, but only 6 for obesity, 2 of which have been taken off market...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28639597/evaluation-of-75-g-glucose-load-in-non-fasting-state-diabetes-in-pregnancy-study-group-of-india-dipsi-criteria-as-a-diagnostic-test-for-gestational-diabetes-mellitus
#15
Reva Tripathi, Divya Verma, Vinod Kumar Gupta, Shakun Tyagi, M Kalaivani, Siddarth Ramji, Y M Mala
BACKGROUND & OBJECTIVES: There is no consensus regarding optimal standard for diagnosis of gestational diabetes mellitus (GDM). In this study, use of 75 g glucose load in non-fasting state [Diabetes in Pregnancy Study Group of India (DIPSI) criteria] as a diagnostic test for GDM in pregnant women was compared with different oral glucose tolerance tests (OGTTs). METHODS: This prospective study included 936 pregnant women, who underwent plasma glucose evaluation two hours after the challenge of 75 g glucose load irrespective of the timing of last meal (DIPSI criteria for GDM)...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28616682/evidence-responsiveness-and-the-ongoing-autonomy-of-treatment-preferences
#16
Steven Weimer
To be an autonomous agent is to determine one's own path in life. However, this cannot plausibly be seen as a one-off affair. An autonomous agent does not merely set herself on a particular course and then lock the steering wheel in place, so to speak, but must maintain some form of ongoing control over her direction in life-must keep her eyes on the road and her hands on the wheel. Circumstances often change in important and unexpected ways, after all, and it is reasonable to think that a crucial part of autonomy consists of the ability and disposition to recognize and properly respond to such changes...
June 14, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28611398/derivation-and-validation-of-a-mortality-risk-score-for-severe-hand-foot-and-mouth-disease-in-china
#17
Jun Qiu, Xiulan Lu, Xiao Liu, Ping Zang, Wenjiao Zhao, Pingping Liu, Zhenghui Xiao
Outbreaks of hand, foot and mouth disease (HFMD) have increased recently, as has the case fatality rate in severe cases. No scoring system currently exists to predict mortality risk for severe HFMD in previous study. We retrospectively collected laboratory parameters for 546 patients with severe HFMD (a derivation and a validation cohort) at Hunan Children's Hospitals between January 2012 and December 2014. We developed a mortality risk score comprising four laboratory parameters: blood glucose (GLU), white blood cells (WBC), lactate (LAC), and N-terminal-probrain natriuretic peptide (NT-proBNP)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596445/development-of-a-new-care-model-for-hospitalized-children-with-medical-complexity
#18
Christine M White, Joanna E Thomson, Angela M Statile, Katherine A Auger, Ndidi Unaka, Matthew Carroll, Karen Tucker, Derek Fletcher, David E Hall, Jeffrey M Simmons, Patrick W Brady
Children with medical complexity are a rapidly growing inpatient population with frequent, lengthy, and costly hospitalizations. During hospitalization, these patients require care coordination among multiple subspecialties and their outpatient medical homes. At a large freestanding children's hospital, a new inpatient model of care was developed in an effort to consistently provide coordinated, family-centered, and efficient care. In addition to expanding the multidisciplinary team to include a pharmacist, dietician, and social worker, the team redesign included: (1) medication reconciliation rounds, (2) care coordination rounds, and (3) multidisciplinary weekly handoff with outpatient providers...
June 8, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28576543/pycnodysostosis-at-otorhinolaryngology
#19
Tekin Baglam, Adem Binnetoglu, Muhammet Fatih Topuz, Nilay Baş Ikizoglu, Refika Ersu, Serap Turan, Murat Sarı
AIM: Pycnodysostosis is a rare autosomal, recessive, skeletal dysplasia caused by a mutation in the cathepsin k gene. Pycnodysostosis is characterized by short stature, characteristic facial appearance (delayed closure of fontanelles and cranial sutures, mandibular hypoplasia and angle disorder, blue sclera), and acroosteolysis of the distal phalanges. Our aim was to describe the otorhinolaryngologic findings, differential diagnoses, various treatment options, and followup in eight cases of pycnodysostosis...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28570092/the-effect-of-physical-exercise-after-a-concussion-a-systematic-review-and-meta-analysis
#20
Avtar Lal, Stephanie A Kolakowsky-Hayner, Jamshid Ghajar, Maya Balamane
BACKGROUND: Data evaluating the role of exercise in patients with a concussion are contradictory. Studies have reported improvement in the Post-Concussion Symptom Scale (PCSS) score, whereas others showed no effect on the PCSS score. PURPOSE: To conduct a systematic review and meta-analysis on the role of physical exercise on different outcomes in patients with a concussion. STUDY DESIGN: Systematic review and meta-analysis. METHODS: A search of 5 databases from the earliest available date to September 30, 2016, and a hand search of a few articles were performed...
June 1, 2017: American Journal of Sports Medicine
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