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Blood wastage

Nancy M Dunbar, Nicholas J Olson, Zbigniew M Szczepiorkowski, Eric D Martin, Ryan M Tysarcyk, Darrell J Triulzi, Louis H Alarcon, Mark H Yazer
BACKGROUND: The purpose of massive transfusion protocols (MTPs) is to provide large quantities of blood products rapidly to exsanguinating patients. The expected rates of blood product transfusion and wastage in this setting have not been defined. This study was undertaken to assess the transfusion and wastage rates for bleeding patients requiring emergency issue of blood components at three American Level I trauma centers. STUDY DESIGN AND METHODS: Three hospitals participated, all of which are Level I trauma centers that have MTPs in place where uncrossmatched red blood cells (RBCs) can be ordered with or without platelets (PLTs), plasma, and cryoprecipitate...
October 23, 2016: Transfusion
N P Soumya, D N Das, S Jeyakumar, S Mondal, A Mor, U T Mundhe
Embryonic mortality is found to be the main source of reproductive wastage in domestic ruminants. Many genes are involved in the growth and development of the embryo, and the interferon-stimulated gene 15 (ISG 15) is one of the major gene stimulated by interferon tau, the maternal recognition of pregnancy signal in ruminants. In this study, both genomic and cDNA sequences of ISG 15 from Bos indicus (Deoni breed) were amplified and characterized. The genomic sequence of Deoni ISG 15 exhibited 99% identity with Bos taurus and 97% identity with that of Bos mutus and Bubalus bubalis...
October 21, 2016: Reproduction in Domestic Animals, Zuchthygiene
Ria R Ghai, Mary I Thurber, Azza El Bakry, Colin A Chapman, Tony L Goldberg
BACKGROUND: Health clinics in rural Africa are typically resource-limited. As a result, many patients presenting with fever are treated with anti-malarial drugs based only on clinical presentation. This is a considerable issue in Uganda, where malaria is routinely over-diagnosed and over-treated, constituting a wastage of resources and an elevated risk of mortality in wrongly diagnosed patients. However, rapid diagnostic tests (RDTs) for malaria are increasingly being used in health facilities...
2016: Malaria Journal
Pasquale L Fedele, Mark N Polizzotto, George Grigoriadis, Neil Waters, Mary Comande, Marija Borosak, David Portbury, Erica M Wood
BACKGROUND: Demand for platelet (PLT) and plasma transfusions is increasing. Improved clinical supply and contingency planning requires greater understanding of usage profiles and urgency of clinical requirement. STUDY DESIGN AND METHODS: This study was a random-sample survey of PLT and plasma units produced in Victoria, Australia, to determine product disposition, recipient demographics, clinical indications for transfusion, and urgency (or "deferability") of need...
October 2016: Transfusion
Zubaida Garba Abdullahi, Mohammmed A Abdul, Sirajo M Aminu, Bolanle O P Musa, Lawal Amadu, El-Bashir M Jibril
CONTEXT: The association between antiphospholipid antibodies (APAs) and pregnancy loss has been established and now considered as a treatable cause of pregnancy loss. Data on the prevalence of APA in patients with recurrent pregnancy loss are scarce in our environment. AIMS: To determine the prevalence of APA in pregnant women with and without recurrent fetal wastage. SETTINGS AND DESIGN: Antenatal clinic of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria...
July 2016: Annals of African Medicine
M Sekhar, S Clark, R Atugonza, A Li, Z Chaudhry
OBJECTIVES: To implement a patient blood management (PBM) programme in platelet transfusion. AIMS: To improve the appropriate use of blood components, reduce wastage and generate savings. BACKGROUND: PBM is a multidisciplinary, evidence-based approach to optimising the care of patients who need blood transfusion and to use blood products appropriately. Strategies for PBM ensure that patients receive the best possible treatment with the transfusion of components when indicated, at the same time avoiding or reducing unnecessary transfusions...
August 10, 2016: Transfusion Medicine
Chi Chiu Mok
INTRODUCTION: Despite the emergence of newer immunomodulating agents for systemic lupus erythematosus (SLE), a substantial proportion of patients still do not respond optimally. While the mechanisms for the differential responses to drug therapy are unclear, variation in drug exposure with the same dosing protocol related to pharmacogenetic and pharmacokinetic factors may contribute. This article discusses the use of therapeutic drug monitoring (TDM) to optimize therapies in SLE patients...
July 22, 2016: Expert Review of Clinical Immunology
Rajini Kurup, Audrey Anderson, Cecil Boston, Lynn Burns, Marian George, Marana Frank
BACKGROUND: Blood is a valuable resource and blood wastage in a low socio economic country could impose a very serious impact on healthcare. This study therefore analyzes the usage and wastage of blood and blood products at the Georgetown Public Hospital Cooperation (GPHC), Guyana. METHODS: A retrospective study was conducted on the data retrieved from laboratory blood banking information system on usage and wastage of blood products during the years 2012-2014 at the public hospital...
2016: BMC Research Notes
Salwa I Hindawi, Maha A Badawi, Edwin T Raj, Kholoud A Gholam, Seraj O Al-Weail, Fatima Azher
OBJECTIVES: To report 2-years experience of using transfusion-related quality indicators as a tool in hemovigilance system implementation.  METHODS: The study was carried out between 2012 and 2013. Blood transfusion service data were prospectively collected at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Donor reactions, transfusion reactions, fresh frozen plasma (FFP) in-date wastage, incidents, and errors pertaining to orders, or requests were collected quarterly and prospectively and forwarded to the Hospital Transfusion Committee (HTC) for review...
May 2016: Saudi Medical Journal
Ravneet Kaur Bedi, Kshitija Mittal, Tanvi Sood, Paramjit Kaur, Gagandeep Kaur
BACKGROUND: Blood inventory management entails maintaining a delicate balance between guaranteeing blood availability and minimizing wastage. The study was conducted to identify and analyze various factors of wastage which can provide insight to ideal inventory management, thus help in formulating policies and improve efficiency of blood transfusion services. MATERIALS AND METHODS: The study was conducted in a tertiary care hospital. To determine various causes of wastage, a retrospective analysis was done over 6 months and preventive strategies adopted...
April 2016: International Journal of Applied and Basic Medical Research
K Foley, D Poles, H Mistry, A Gray, P H B Bolton-Maggs
OBJECTIVES: To discover if any adverse clinical effects have been reported to the UK haemovigilance scheme, Serious Hazards of Transfusion (SHOT) relating to delays in set up of transfusion or extended transfusion time for red cell units. BACKGROUND: Current guidance for duration of transfusion is based on outdated studies that do not reflect current UK Blood Service practices. Recent evidence suggests that the '30-min rule' could be extended without adverse effects...
June 2016: Transfusion Medicine
Anshu Gupta, Chhavi Gupta
CONTEXT: Certain quality indicators are mandatory in the maintenance and improvement of quality in blood transfusion. Monitoring of such indicators should be done regularly and deficiencies are to be corrected for effective blood transfusion services. AIMS: To study the usefulness of monitoring of the National Accreditation Board for Hospitals and Healthcare Providers (NABH) core indicators in blood transfusion and in the maintenance of hemovigilance. SETTINGS AND DESIGN: Hemovigilance is a quality process to improve quality and increase the safety of blood transfusion...
January 2016: Asian Journal of Transfusion Science
Arash Peivandi Yazdi, Mohammad Alipour, Seyyed Saeed Jahanbakhsh, Mohammad Gharavifard, Mehryar Taghavi Gilani
BACKGROUND: Reservation of blood leads to blood wastage if the blood is not transfused. Therefore, in some centers only blood type and screen are evaluated. In this study, the efficacy of a blood crossmatch-to-transfusion ratio was measured and then compared with the standard levels. METHODS: This prospective study was conducted during one year in a university hospital. During this period, 398 patients for whom blood had been requested were studied. In these patients, at the first surgical type, the laboratory tests (hematocrit, hemoglobin, platelet count, and prothrombin time) and the number of preoperative crossmatched and intraoperative transfused blood units were recorded...
January 2016: Archives of Bone and Joint Surgery
Joseph B Rinehart, Tiffany C Lee, Kayleigh Kaneshiro, Minh-Ha Tran, Coral Sun, Zeev N Kain
BACKGROUND: As part of ongoing perioperative surgical home implantation process, we applied a previously published algorithm for creation of a maximum surgical blood order schedule (MSBOS) to our operating rooms. We hypothesized that using the MSBOS we could show a reduction in unnecessary preoperative blood testing and associated costs. STUDY DESIGN AND METHODS: Data regarding all surgical cases done at UC Irvine Health's operating rooms from January 1, 2011, to January 1, 2014 were extracted from the anesthesia information management systems (AIMS)...
April 2016: Transfusion
Zahir Mughal, Aravindan Narayanan, Vivek Gupta, Nick Reay-Jones
BACKGROUND: Unnecessary blood tests are estimated to contribute to 25% of wastage in the National Health Service. The aim of this study was to assess the financial implication of clinical need-focused blood tests guided by a senior clinician in a district general hospital. METHODS: We conducted an observational longitudinal study over six months with pre- and postanalysis of a vetting intervention. A colorectal firm (Team A) implemented a vetting system that required a registrar or consultant to discuss which blood tests needed to be requested for each in-patient with junior doctors...
September 2016: Annals of Clinical Biochemistry
Mark H Yazer, Diana S Deandrade, Darrell J Triulzi, Mary Kay Wisniewski, Jonathan H Waters
BACKGROUND: The effect on component wastage after enhancing the clinician's ability to order blood products in the computerized physician order entry (CPOE) system was investigated in a multihospital network. METHODS: A novel field was added to the CPOE of eight hospitals within a health care system allowing the physician to reserve a red blood cell (RBC) unit for transfusion at a later time. Simultaneously, an electronic means of communication with the blood bank was implemented requiring the nurse to ensure that the patient was prepared for the transfusion before a product could be issued...
March 2016: Transfusion
M Bots, E P L M de Grouw, I H M van Rooyen-Schreurs, G J van den Akker, A Sturk, J H Klinkspoor, S S Zeerleder
BACKGROUND AND OBJECTIVES: Wastage of red blood cell units (RBCs) due to their inappropriate storage at the clinical ward has become both a financial and ethical challenge in the daily hospital practice. This study was aimed at identifying the extent of RBC wastage and evaluating the effects of various interventions in reducing this wastage. MATERIALS AND METHODS: From January 2011 to March 2011, baseline wastage level was evaluated using temperature-sensitive labels...
February 2016: Vox Sanguinis
Hazel Tinegate, Kate Pendry, Michael Murphy, Paul Babra, John Grant-Casey, Cathy Hopkinson, Jot Hyare, Megan Rowley, Frances Seeney, Denise Watson, Jonathan Wallis
BACKGROUND: Knowledge of blood utilization can assist clinicians in directing patient blood management (PBM) initiatives and can facilitate demand planning by blood services. We describe a national study of red blood cell (RBC) utilization in England and North Wales in 2014. STUDY DESIGN AND METHODS: All hospitals that are supplied with blood components by NHS Blood and Transplant (NHSBT) were asked to provide data on the age and sex of all recipients of transfusions of RBCs, and the clinical indication for every unit transfused, for two separate weeks in 2014...
January 2016: Transfusion
Dania Fischer, Julian Büssow, Patrick Meybohm, Kai Zacharowski, Carla Jennewein
BACKGROUND: Basic research on the pathomechanisms of transfusion-related adverse events depends on murine transfusion models, in which leukoreduction (LR) is a prevalent standard. The commonly used neonatal LR filter (LRF) is associated with considerable animal numbers. A more efficient method would help support the guiding principles of "replacement, reduction, refinement" (3Rs). STUDY DESIGN AND METHODS: Blood from C57BL/6 and C57BL/6-Tg(UBC-GFP)30Scha/J mice was leukoreduced using (1) a neonatal LRF, (2) a syringe LRF, or (3) CD45 microbeads...
January 2016: Transfusion
Michael P Kelly, Lukas P Zebala, Han Jo Kim, Daniel M Sciubba, Justin S Smith, Christopher I Shaffrey, Shay Bess, Eric Klineberg, Gregory Mundis, Douglas Burton, Robert Hart, Alex Soroceanu, Frank Schwab, Virginie Lafage
OBJECTIVE: The goal of this study was to examine the effectiveness of preoperative autologous blood donation (PABD) in adult spinal deformity (ASD) surgery. METHODS: Patients undergoing single-stay ASD reconstructions were identified in a multicenter database. Patients were divided into groups according to PABD (either PABD or NoPABD). Propensity weighting was used to create matched cohorts of PABD and NoPABD patients. Allogeneic (ALLO) exposure, autologous (AUTO) wastage (unused AUTO), and complication rates were compared between groups...
January 2016: Journal of Neurosurgery. Spine
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