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Blood wastage

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https://www.readbyqxmd.com/read/29772289/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress-towards-approval-of-anti-alzheimer-drugs
#1
REVIEW
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29751949/platelet-storage-lesions-what-more-do-we-know-now
#2
REVIEW
Monica Suet Ying Ng, John-Paul Tung, John Francis Fraser
Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate availability and safety are limited by the development of platelet storage lesions (PSLs) and risk of bacterial contamination. Platelet storage lesions are a series of biochemical, structural, and functional changes that occur from blood collection to transfusion. Understanding of PSLs is key for devising interventions that prolong PC shelf life to improve PC access and wastage...
April 17, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29708621/approaches-to-minimize-blood-product-wastage
#3
Lisa Hauk
No abstract text is available yet for this article.
May 2018: AORN Journal
https://www.readbyqxmd.com/read/29708613/severe-blood-shortages-reinforce-the-importance-of-reducing-wastage
#4
Lisa Hauk
No abstract text is available yet for this article.
May 2018: AORN Journal
https://www.readbyqxmd.com/read/29682030/maximum-surgical-blood-order-schedule-for-elective-neurosurgery-in-a-university-teaching-hospital-in-northern-thailand
#5
Ananchanok Saringcarinkul, Siriwan Chuasuwan
Context: Preoperative blood bank testing should optimize the trade-off between intraoperative transfusion delay and blood wastage. Aims: This study aims to develop a maximal surgical blood order schedule (MSBOS) for elective neurosurgery. Settings and Design: Prospective data in University Teaching Hospital, Northern Thailand. Subjects and Methods: Blood transfusion data were collected on all adult patients satisfying inclusion/exclusion criteria in 2015...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29624677/logistical-and-safety-implications-of-temperature-based-acceptance-of-returned-red-blood-cell-units
#6
Robert A DeSimone, Michael D Nowak, Dian T Lo, Kathleen M Crowley, Priscilla Parra, Melissa M Cushing, Yen-Michael S Hsu
BACKGROUND: AABB requires that red blood cells (RBCs) are maintained at 1 to 10°C during transport. Historically, blood banks used the 30-minute rule for returned RBCs transported outside of validated containers. The implications of this policy have not been previously reported in a real-life hospital setting. STUDY DESIGN AND METHODS: A 2-year, retrospective review of RBC units returned outside of qualified containers was conducted. During the first year, the 30-minute rule was used to accept RBCs back into inventory...
April 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29516503/blood-product-transfusion-and-wastage-rates-in-obstetric-hemorrhage
#7
Mark H Yazer, Nancy M Dunbar, Claudia Cohn, Jessica Dillon, Howida Eldib, Bryon Jackson, Richard Kaufman, Michael F Murphy, Kerry O'Brien, Jay S Raval, Jansen Seheult, Julie Staves, Jonathan H Waters
BACKGROUND: Bleeding emergencies can complicate pregnancies. Understanding the disposition of the products that are issued in this clinical setting can help inform inventory levels at hospitals where obstetric patients are seen. STUDY DESIGN AND METHODS: Patients who had an obstetric hemorrhage of any etiology between January 2013 and June 2017, and whose resuscitation began with uncrossmatched red blood cells (RBCs) or emergency-issued plasma or platelets (PLT), were included...
March 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29425284/chromosomal-instability-in-women-with-primary-ovarian-insufficiency
#8
Sunita Katari, Mahmoud Aarabi, Angela Kintigh, Susan Mann, Svetlana A Yatsenko, Joseph S Sanfilippo, Anthony J Zeleznik, Aleksandar Rajkovic
STUDY QUESTION: What is the prevalence of somatic chromosomal instability among women with idiopathic primary ovarian insufficiency (POI)? SUMMARY ANSWER: A subset of women with idiopathic POI may have functional impairment in DNA repair leading to chromosomal instability in their soma. WHAT IS KNOWN ALREADY: The formation and repair of DNA double-strand breaks during meiotic recombination are fundamental processes of gametogenesis. Oocytes with compromised DNA integrity are susceptible to apoptosis which could trigger premature ovarian aging and accelerated wastage of the human follicle reserve...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29416844/negative-peri-donation-events-among-whole-blood-donors-in-a-blood-bank-in-ibadan-nigeria
#9
Foluke A Fasola
The existence and sustenance of the blood bank depends on blood donors. It is imperative that the donation experience is satisfactory for the donors. Therefore this study was carried out to determine the frequency of undesirable events experienced by the blood donor as part of donor haemovigilance. This was a retrospective descriptive study of the events that occurred amongst the blood donors of the blood bank of a tertiary institution. The blood donor incident book was reviewed for the period of six months...
December 31, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/29380872/accurate-costs-of-blood-transfusion-a-microcosting-of-administering-blood-products-in-the-united-kingdom-national-health-service
#10
Elizabeth A Stokes, Sarah Wordsworth, Julie Staves, Nicola Mundy, Jane Skelly, Kelly Radford, Simon J Stanworth
BACKGROUND: In an environment of limited health care resources, it is crucial for health care systems which provide blood transfusion to have accurate and comprehensive information on the costs of transfusion, incorporating not only the costs of blood products, but also their administration. Unfortunately, in many countries accurate costs for administering blood are not available. Our study aimed to generate comprehensive estimates of the costs of administering transfusions for the UK National Health Service...
April 2018: Transfusion
https://www.readbyqxmd.com/read/29361963/diagnostic-tools-in-childhood-malaria
#11
REVIEW
Amirah Amir, Fei-Wen Cheong, Jeremy R De Silva, Yee-Ling Lau
Every year, millions of people are burdened with malaria. An estimated 429,000 casualties were reported in 2015, with the majority made up of children under five years old. Early and accurate diagnosis of malaria is of paramount importance to ensure appropriate administration of treatment. This minimizes the risk of parasite resistance development, reduces drug wastage and unnecessary adverse reaction to antimalarial drugs. Malaria diagnostic tools have expanded beyond the conventional microscopic examination of Giemsa-stained blood films...
January 23, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29315622/patient-rescue-and-blood-utilization-in-the-ogasawara-blood-rotation-system
#12
Tomoko Igarashi, Hiroshi Fujita, Hiroyuki Asaka, Yuko Takada, Rieko Ametani, Itsuki Naya, Yasushi Tanaka, Makoto Kamesaki, Asuka Kasai
BACKGROUND: In the past, blood products were not transported to the Ogasawara Islands because of the distance; the islands are approximately 1000 km from the mainland and lack an airport. The Ogasawara Blood Rotation system involves the routine, long-distance transportation of Type O, RhD-positive, irradiated red blood cells to rescue patients with acute hemorrhage and severe anemia and to reduce wastage from the expiration of red blood cell solution. STUDY DESIGN AND METHODS: Blood transfusion and utilization in the Ogasawara blood rotation (BR) system were examined from December 2014 to March 2017...
March 2018: Transfusion
https://www.readbyqxmd.com/read/29157876/evaluating-the-effect-of-tariff-on-wastage-and-return-of-blood-products-in-kerman-province
#13
H Anani, I Baluchi, M Ghazizadeh, H Mardani Valandani, R Mirzaee Khalilabadi
BACKGROUND: In Iran blood products had been available to health care centers on free order to reduce the wastage they were tariffed in 2016. Thus, health care centers must pay for the blood products and take back the payment from the insurance. The aim of this study was to examine the effects of the tariff on consumption, wastage and return rates of blood products in health care centers in Kerman province. MATERIALS AND METHODS: In this retrospective cross-sectional study, demand, delivery and return rates of blood products (fresh frozen plasma, red blood cell and platelet) were examined in 23 health care centers and hospitals before and after the tariff...
February 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29153350/management-of-mobilization-failure-in-2017
#14
Sinem Namdaroglu, Serdal Korkmaz, Fevzi Altuntas
In contemporary clinical practice, almost all allogeneic transplantations and autologous transplantations now capitalize on peripheral blood stem cells (PBSCs) as opposed to bone marrow (BM) for the source of stem cells. In this context, granulocyte colony-stimulating factor (G-CSF) plays a pivotal role as the most frequently applied frontline agent for stem cell mobilization. For patients classified as high-risk, chemotherapy based mobilization regimens can be preferred as a first choice and it is notable that this also used for remobilization...
December 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29131870/-low-platelet-usage-haematology-laboratories-to-store-or-not-to-store
#15
COMPARATIVE STUDY
M Elmi, B Sirigireddy, J Abukar, D Tchipeva, N Chauhan, D A Tsitsikas
In the UK, hospitals with annual platelet use of less than 500 pools, like our institution, usually do not store platelets on-site and these are only ordered from the national blood service (NBS) when a transfusion is required. In 2016, we piloted routine on-site storage of one pool of A RhD negative PLT. Data were collected retrospectively on units of PLTs ordered from NBS, units transfused to patients, wastage, requirements for emergency deliveries from NBS and overall cost. These were compared to corresponding data from the four preceding years (2012-2015)...
2017: PloS One
https://www.readbyqxmd.com/read/29078874/14-day-thawed-plasma-retains-clot-enhancing-properties-and-inhibits-tpa-induced-fibrinolysis
#16
Benjamin R Huebner, Ernest E Moore, Hunter B Moore, Raymond Shepherd-Singh, Angela Sauaia, Gregory R Stettler, Geoffrey R Nunns, Christopher C Silliman
BACKGROUND: Plasma-first resuscitation attenuates trauma-induced coagulopathy (TIC); however, the logistics of plasma-first resuscitation require thawed plasma (TP) be readily available due to the obligatory thawing time of fresh frozen plasma (FFP). The current standard is storage of TP for up to 5 days at 4°C, based on factor levels at outdate, for use in patients at risk for TIC, but there remains a 2.2% outdated wastage rate. However, the multitude of plasma proteins in attenuating TIC remains unknown...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29073058/big-data-modeling-to-predict-platelet-usage-and-minimize-wastage-in-a-tertiary-care-system
#17
Leying Guan, Xiaoying Tian, Saurabh Gombar, Allison J Zemek, Gomathi Krishnan, Robert Scott, Balasubramanian Narasimhan, Robert J Tibshirani, Tho D Pham
Maintaining a robust blood product supply is an essential requirement to guarantee optimal patient care in modern health care systems. However, daily blood product use is difficult to anticipate. Platelet products are the most variable in daily usage, have short shelf lives, and are also the most expensive to produce, test, and store. Due to the combination of absolute need, uncertain daily demand, and short shelf life, platelet products are frequently wasted due to expiration. Our aim is to build and validate a statistical model to forecast future platelet demand and thereby reduce wastage...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28988805/prediction-of-massive-blood-transfusion-in-battlefield-trauma-development-and-validation-of-the-military-acute-severe-haemorrhage-mash-score
#18
Jacqueline V Mclennan, Kevin C Mackway-Jones, Jason E Smith
BACKGROUND: The predominant cause of preventable trauma death is bleeding, and many of these patients need resuscitation with massive blood transfusion. In resource-constrained environments, early recognition of such patients can improve planning and reduce wastage of blood products. No existing decision rule is sufficiently reliable to predict those patients requiring massive blood transfusion. This study aims to produce a decision rule for use on arrival at hospital for patients sustaining battlefield trauma...
February 2018: Injury
https://www.readbyqxmd.com/read/28965799/multifactorial-risk-index-for-prediction-of-intraoperative-blood-transfusion-in-endovascular-aneurysm-repair
#19
Eitezaz Mahmood, Robina Matyal, Ariel Mueller, Feroze Mahmood, Avery Tung, Mario Montealegre-Gallegos, Marc Schermerhorn, Sajid Shahul
BACKGROUND: In some institutions, the current blood ordering practice does not discriminate minimally invasive endovascular aneurysm repair (EVAR) from open procedures, with consequent increasing costs and likelihood of blood product wastage for EVARs. This limitation in practice can possibly be addressed with the development of a reliable prediction model for transfusion risk in EVAR patients. We used the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database to create a model for prediction of intraoperative blood transfusion occurrence in patients undergoing EVAR...
March 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28940216/zeroing-in-on-red-blood-cell-unit-expiry
#20
Fathima Ayyalil, Greg Irwin, Bryony Ross, Michael Manolis, Anoop K Enjeti
BACKGROUND: Expiry of red blood cell (RBC) units is a significant contributor to wastage of precious voluntary donations. Effective strategies aimed at optimal resource utilization are required to minimize wastage. STUDY DESIGN AND METHODS: This retrospective study analyzed the strategic measures implemented to reduce expiry of RBC units in an Australian tertiary regional hospital. The measures, which included inventory rearrangement, effective stock rotation, and the number of emergency courier services required during a 24-month period, were evaluated...
December 2017: Transfusion
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