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Histiocytic sarcoma

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https://www.readbyqxmd.com/read/29444632/immunohistochemical-labeling-of-multiple-myeloma-oncogene-1-interferon-regulatory-factor-4-mum1-irf-4-in-canine-cutaneous-histiocytoma
#1
Justin M Stilwell, Daniel R Rissi
Multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF-4) immunohistochemistry (IHC) is mainly used for diagnostic confirmation of plasma cell tumors (PCTs) in dogs and cats. This article describes MUM1/IRF-4 IHC expression in 20 cases of canine cutaneous histiocytoma (CH) and compares it with 10 cutaneous or mucocutaneous PCTs and 5 cutaneous histiocytic sarcomas (HSs) submitted to the same IHC protocol. All histiocytomas had strong nuclear and variable cytoplasmic immunolabeling for MUM1/IRF-4, whereas all PCTs had strong nuclear and moderate cytoplasmic immunolabeling for MUM1/IRF-4...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29414400/primary-cutaneous-histiocytic-sarcoma-a-report-of-five-cases-with-primary-cutaneous-involvement-and-review-of-the-literature
#2
Cynthia M Magro, Najiyah Kazi, Aimee E Sisinger
INTRODUCTION: Histiocytic sarcoma is an extremely rare hematologic malignancy of histiocytic origin. Five cases of primary cutaneous histiocytic sarcoma are presented. MATERIALS AND METHODS: Cases of primary cutaneous histiocytic sarcoma were identified using a natural language search from the dermatopathology data base of Cornell University. RESULTS: There was a male predominance (4 males and 1 female) ranging in age from 33years to 92years (mean age of 73years); all presented with a solitary nodule which involved the head and neck area in four and thigh in one...
February 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29406562/synovial-cell-sarcoma-in-a-dog-a-misnomer-cytologic-and-histologic-findings-and-review-of-the-literature
#3
REVIEW
Paola Monti, Darren Barnes, Anna M Adrian, Roberta Rasotto
A 4-year-old Irish Setter was presented with a history of progressive left pelvic limb lameness. Orthopedic examination revealed pain on manipulation of the left stifle. Radiographs showed an osteolytic lesion in the subchondral bone of the medial tibial condyle. Fine-needle aspirates were taken, and cytology revealed numerous cohesive clusters of plump, oval to spindloid cells often with perivascular distribution and moderate cellular atypia. A diagnosis of sarcoma was made with synovial cell sarcoma (SCS) and histiocytic sarcoma being the 2 main differentials...
February 6, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29398759/tubercular-mycobacterial-spindle-cell-pseudotumour-a-case-report
#4
Deba Prasad Dhibar, Kamal Kant Sahu, Surjit Singh, Amanjit Bal, Abhijit Chougale, Varun Dhir
Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacterium avium complex (MAC). Here, we present the case of a 38-year-old gentleman with acquired immune deficiency syndrome (AIDS) who presented with low-grade fever for 1-month duration. Clinically, he had generalised lymphadenopathy...
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29351196/a-case-report-of-disseminated-canine-histiocytic-sarcoma-in-trinidad-and-tobago
#5
Stacy Rajh, Karelma Frontera Acevedo, Gillian Williams, Indira Pargass, Alissa Bally, Rod Suepaul
Ocular histiocytic sarcomas (as a presenting part of disseminated histiocytic sarcoma) are not commonly diagnosed. A 10-year-old female intact Rottweiler presented to the School of Veterinary Medicine, Trinidad with buphthalmia and pain in the left eye. The cornea of the left eye appeared diffusely opaque with a conjunctival mucopurulent ocular discharge. A thorough ophthalmic assessment identified an intraocular proliferative tumor to which a unilateral enucleation was performed, however the animal died soon after...
January 19, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29327713/expression-of-enhancer-of-zeste-homolog-2-ezh2-protein-in-histiocytic-and-dendritic-cell-neoplasms-with-evidence-for-p-erk1-2-related-but-not-myc-or-p-stat3-related-cell-signaling
#6
Xuejun Tian, Jie Xu, Christopher Fletcher, Jason L Hornick, David M Dorfman
EZH2 is an important enzymatic subunit of the epigenetic regulator polycomb repressive complex 2 (PRC2), which controls gene silencing through post-translational modification, and is overexpressed in various carcinomas and hematopoietic neoplasms. We found that the majority of cases of histiocytic and dendritic cell neoplasms, including histiocytic sarcoma, follicular dendritic cell sarcoma, Langerhans cell histiocytosis, and interdigitating dendritic cell sarcoma, show strong EZH2 expression by immunohistochemical staining, in contrast to benign histiocytic lesions and normal cellular counterparts, which did not show EZH2 expression, suggesting that this molecule may function as an oncogenic protein in these neoplasms...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29290317/histiocytic-sarcoma-with-bladder-involvement-case-report-and-literature-review
#7
Mª Jesús Fernández-Aceñero, Pablo Pérez Alonso, Cristina Díaz Del Arco
We report an unusual case of histiocytic sarcoma with bladder involvement. An 80 year-old man with a previous history of diffuse large B-cell malignant lymphoma presented with hematuria and back pain. Serial urine cytologies revealed no urothelial malignant cells, but cystoscopy showed a large intravesical mass. The patient underwent transurethral resection (TUR) of the tumor. The bladder TUR specimen showed a widely infiltrating epithelioid neoplasm, with intense immunohistochemical positivity for CD45 and histiocytic markers (CD68, lysozime and fascin)...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29275293/morphological-distinction-of-histiocytic-sarcoma-from-other-tumor-types-in-bernese-mountain-dogs-and-flatcoated-retrievers
#8
Suzanne A Erich, Fernando Constantino-Casas, Jane M Dobson, Erik Teske
BACKGROUND/AIM: Histiocytic sarcoma (HS) represents a group of malignant canine tumors to which Bernese Mountain Dogs (BMD) and Flatcoated Retrievers (FCR) are predisposed. The differential diagnosis for HS is broad, encompassing round cell tumors, sarcomas and other histiocytic diseases. The aim of this study was to establish morphological and immunohistochemical criteria for routine use on formalin-fixed, paraffin-embedded samples and cytological smears for the recognition and differentiation of canine HS and its subtypes...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29247539/fluorescein-sodium-guided-resection-of-intracranial-lesions-in-22-dogs
#9
Yukiko Nakano, Kohei Nakata, Sanae Shibata, Yasuhiro Heishima, Hidetaka Nishida, Hiroki Sakai, Hirohito Yano, Hiroaki Kamishina
OBJECTIVE: To evaluate the safety of an intraoperative fluorescein sodium (FS) injection and elucidate the relationships between the MRI findings, pathological diagnoses, and intraoperative staining characteristics of intracranial lesions in 22 dogs. STUDY DESIGN: Prospective case series. ANIMALS: Twenty-two dogs with intracranial lesions. METHODS: FS was intravenously administered to 22 dogs undergoing craniotomy for suspected intracranial tumors to evaluate perioperative and postoperative adverse effects...
December 16, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29228722/prognostic-factors-for-histiocytic-and-dendritic-cell-neoplasms
#10
Joji Shimono, Hiroaki Miyoshi, Fumiko Arakawa, Kensaku Sato, Takuya Furuta, Reiji Muto, Eriko Yanagida, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Nagafuji, Koichi Ohshima
Histiocytic and dendritic cell neoplasms are rare and poorly studied. We report the clinical characteristics and prognostic factors in such cases in Japan. We investigated the clinical characteristics and survival in 87 adult patients with histiocytic and dendritic cell neoplasms. Fifty patients had histiocytic sarcoma, 12 had Langerhans cell histiocytosis, 11 had follicular dendritic cell sarcoma, 8 had Langerhans cell sarcoma, 6 had interdigitating cell sarcoma and 1 had indeterminate dendritic cell sarcoma...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29194093/cdkn2a-b-deletion-and-double-hit-mutations-of-the-mapk-pathway-underlie-the-aggressive-behavior-of-langerhans-cell-tumors
#11
Luc Xerri, José Adélaïde, Cornel Popovici, Séverine Garnier, Arnaud Guille, Lenaïg Mescam-Mancini, Camille Laurent, Pierre Brousset, Carole Coze, Gérard Michel, Max Chaffanet, Reda Bouabdallah, Diane Coso, François Bertucci, Daniel Birnbaum
Langerhans cell histiocytosis (LCH) has a mostly favorable outcome, whereas Langerhans cell sarcoma (LCS) is an aggressive tumor. It is still unclear whether any specific molecular alterations could underlie the aggressive behavior of Langerhans cell proliferations. We used targeted next-generation sequencing and array-comparative genomic hybridization to profile 22 LCH samples from different patients together with 3 LCS samples corresponding to different relapses from the same patient. The third LCS relapse was a composite tumor including both B-cell chronic lymphocytic leukemia and LCS components...
November 29, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29189378/simultaneous-brain-and-lung-histiocytic-sarcoma-revealed-on-18f-fdg-pet-ct
#12
Yu Pan, Yifan Zhang
A 52-year-old man with intermittent head motor tics, aphasia and right upper extremity weakness had an F-FDG avid left front lobe brain lesion, and a left upper lobe lung lesion on PET/CT. The brain lesion was surgically resected, and was diagnosed pathologically as a histiocytic sarcoma (HS). The lung lesion was also a HS via bronchial biopsy. HS is rare and generally involves nodes as shown on PET/CT in a few case reports. The current case with simultaneous brain and lung HS lesions adds new imaging pattern information of the disease to the literature...
November 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29183888/histiocytic-sarcoma-a-population-based-analysis-of-incidence-demographic-disparities-and-long-term-outcomes
#13
LETTER
Anuhya Kommalapati, Sri Harsha Tella, Martin Durkin, Ronald S Go, Gaurav Goyal
No abstract text is available yet for this article.
January 11, 2018: Blood
https://www.readbyqxmd.com/read/29181991/chest-wall-resection-and-reconstruction-for-rosai-dorfman-disease-masquerading-as-a-chest-wall-sarcoma
#14
V Joshi, G Offer, C Richards, S Rathinam
Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disease that can present as a pseudotumour of soft tissue. We describe the first chest wall resection and reconstruction.
November 28, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29169617/primary-histiocytic-sarcoma-of-the-brain-in-an-african-hedgehog-atelerix-albiventris
#15
Kikumi Ogihara, Kaoru Suzuki, Hiroo Madarame
A 2.5-year-old African hedgehog (Atelerix albiventris) with signs of progressive paresis/paralysis for approximately 6 months was diagnosed with 'wobbly hedgehog syndrome' (WHS). Post-mortem examination revealed a primary central nervous system (CNS) histiocytic sarcoma (HS) associated with neurodegenerative changes of the CNS and skeletal muscle atrophy. Grossly, a spherical mass infiltrated the left forebrain and was located between the frontal lobe and thalamus in coronal sections. Microscopically, the neoplastic cells had eccentrically located anisokaryotic nuclei and abundant eosinophilic cytoplasm...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29105675/-a-case-of-pulmonary-artery-sarcoma-and-review-of-the-literature
#16
Maria Chiara Todaro, Renzo Orlassino, Cristina Fornengo, Adriana Ravera, Giuseppe Macchia, Francesco Soffiantino, Rina Lionella Lovato, Gaetano Senatore
Pulmonary artery sarcoma (PAS) is a highly malignant tumor that originates in the pulmonary artery. This disease has a poor prognosis. Early diagnosis followed by radical surgical resection constitutes the only chance of survival for patients. However, owing to the rare and nonspecific clinical manifesta-tions and imaging findings, PAS is frequently misdiagnosed as various pulmonary thromboembolic diseases. We report the case of a 49-year-old woman who presented to our emergency department for dyspnea, hemoptysis, cough, and asthenia...
November 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29097496/response-to-mek-inhibition-with-trametinib-and-tyrosine-kinase-inhibition-with-imatinib-in-multifocal-histiocytic-sarcoma
#17
Sophie Voruz, Anne Cairoli, Olaia Naveiras, Laurence de Leval, Edoardo Missiaglia, Krisztian Homicsko, Olivier Michielin, Sabine Blum
No abstract text is available yet for this article.
November 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28958257/cutaneous-manifestation-of-histiocytic-sarcoma-presentation-and-management
#18
Joseph Zakhary, Jorge de la Torre
No abstract text is available yet for this article.
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28929581/gain-of-function-mutation-in-ptpn11-in-histiocytic-sarcomas-of-bernese-mountain-dogs
#19
T Thaiwong, S Sirivisoot, M Takada, V Yuzbasiyan-Gurkan, M Kiupel
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm of dendritic cell origin that is common in certain breeds of dogs. High prevalence of fatal, disseminated HS has been described in Bernese Mountain Dogs (BMDs). Support for genetic predisposition to develop HS has been presented in several studies, but to date, causative genetic events have not been reported. In addition, no driver mutations have been identified in tumours. Recently, E76K gain-of-function mutation in SHP2 encoded by the PTPN11 gene has been described in human histiocytic malignancies...
September 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28924109/retroperitoneal-bulky-histiocytic-sarcoma-successfully-treated-with-induction-chemotherapy-followed-by-curative-surgery
#20
Masafumi Oto, Akiko Maeda, Taku Nose, Yujiro Ueda, Shima Uneda, Akito Inadome, Koichi Oshima, Minoru Yoshida
Histiocytic sarcoma (HS) is a rare hematopoietic neoplasm. We report a patient with HS treated with induction chemotherapy followed by curative surgery. A 50-year-old man was referred to our hospital because of a retroperitoneal tumor. A computed tomography scan revealed a bulky retroperitoneal mass, infiltrating the surrounding organ. An excisional biopsy confirmed the diagnosis of HS. The tumor shrunk after multidrug chemotherapy. However, positron emission tomography showed uptake of fludeoxyglucose in the residual tumor...
October 15, 2017: Internal Medicine
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