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Histiocytic sarcoma

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https://www.readbyqxmd.com/read/28178429/variations-in-histiocytic-differentiation-of-cell-lines-from-canine-cerebral-and-articular-histiocytic-sarcomas
#1
A Thongtharb, K Uchida, J K Chambers, H Nakayama
Two newly established canine histiocytic sarcoma (HS) cell lines, designated as PWC-HS01 and FCR-HS02, were obtained from brain and articular tumors, respectively. These 2 HS cell lines had phagocytic ability and modal chromosome aberrations. Although morphologic features of both HS cells were similar, immunocytochemical examinations revealed that the PWC-HS01 cell line expressed both dendritic cell (ie, S100, CD208, CD1, and CD4) and macrophage (ie, CD68, CD163, and CD204) markers. In contrast, the FCR-HS02 cell line was immunonegative for CD204 and CD68 but consistently positive for the dendritic cell markers...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28160308/invasive-histiocytic-sarcoma-of-the-lumbar-spine-in-a-ferret-mustela-putorius-furo
#2
M Warschau, M Hoffmann, P Dziallas, F Hansmann, W Baumgärtner, R Mischke, S Cichowski, M Fehr
This report describes the history, clinical examination and histopathology of a histiocytic sarcoma in a domestic ferret. Clinical signs were acute paraplegia and dysuria. Physical examination revealed a firm, smooth, touch-sensitive mass in and around the lumbar vertebral column. Neurologic examination was consistent with a lesion between spinal cord segments T3 and L3. Magnetic resonance images revealed bone lesions of L2 and L3 combined with compression of the spinal cord due to a homogenous, isointense mass that was diagnosed as a malignant round cell tumour and the ferret was euthanased...
February 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28129095/t-lymphocytes-in-histiocytic-sarcomas-of-flat-coated-retriever-dogs
#3
A Marcinowska, F Constantino-Casas, T Williams, T Hoather, B Blacklaws, J Dobson
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such tumors. The objective of this study was to examine the presence and expression of regulatory T cells in HS tumor samples. Forty tumors were included in this study. All tumors were immunolabeled for CD3, CD79a, CD25, CD45RA, and FOXP3. The proportion of positive cells was compared between tumors presenting as a localized primary soft tissue mass (soft tissue origin HS) and disseminated HS affecting viscera, especially the spleen (splenic origin HS)...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28124421/in-this-issue-january-february-2017-experimental-hendra-virus-infection-of-dogs%C3%A2-%C3%A2-%C3%A2-brucella-suis-in-dogs%C3%A2-%C3%A2-%C3%A2-cytokines-in-stored-packed-red-blood-cells%C3%A2-%C3%A2-%C3%A2-transitional-lumbosacral-vertebrae-in-labradors%C3%A2-%C3%A2-%C3%A2-chemotherapy-for-histiocytic-sarcomas%C3%A2-%C3%A2-%C3%A2-pyothorax
#4
EDITORIAL
https://www.readbyqxmd.com/read/28124419/chemotherapy-for-dogs-with-lymph-node-metastasis-from-histiocytic-sarcomas
#5
A S Moore, D P Taylor, G Reppas, A E Frimberger
BACKGROUND: Histiocytic sarcomas (HS) frequently metastasise, most commonly to visceral sites, but also to regional lymph nodes. Nodal metastases are associated with a poorer prognosis. This retrospective study aimed to evaluate prognostic factors, including the effect of adjuvant chemotherapy, on survival in dogs with nodal, but not systemic, metastases from HS. METHODS: Retrospective case series of 12 dogs with histologically diagnosed HS metastatic to lymph nodes treated with surgery with and without adjuvant chemotherapy...
January 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28087030/dermoscopic-characteristics-of-a-cutaneous-histiocytic-sarcoma-in-a-young-patient
#6
Ines Escandell, Maria Dolores Ramon, Sara Sánchez, Liria Terradez, Esperanza Jorda
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27911942/persistent-morbillivirus-infection-leads-to-altered-cortactin-distribution-in-histiocytic-sarcoma-cells-with-decreased-cellular-migration-capacity
#7
Vanessa Maria Pfankuche, Mohamed Sayed-Ahmed, Vanessa Bono Contioso, Ingo Spitzbarth, Karl Rohn, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcomas represent rare but fatal neoplasms in humans. Based on the absence of a commercially available human histiocytic sarcoma cell line the frequently affected dog displays a suitable translational model. Canine distemper virus, closely related to measles virus, is a highly promising candidate for oncolytic virotherapy. Therapeutic failures in patients are mostly associated with tumour invasion and metastasis often induced by misdirected cytoskeletal protein activities. Thus, the impact of persistent canine distemper virus infection on the cytoskeletal protein cortactin, which is frequently overexpressed in human cancers with poor prognosis, was investigated in vitro in a canine histiocytic sarcoma cell line (DH82)...
2016: PloS One
https://www.readbyqxmd.com/read/27890406/cutaneous-histiocytic-sarcoma-with-regional-lymph-node-metastasis-in-a-netherland-dwarf-rabbit-oryctolagus-cuniculus
#8
M R Karim, T Izawa, M Pervin, H Sasai, M Kuwamura, J Yamate
A 10-year-old male Netherland dwarf rabbit (Oryctolagus cuniculus) was presented with a red nodular mass (1 cm in diameter) with ulceration and hair loss in the skin of the left upper lip. Cytological examination revealed atypical round cells. The mass was excised surgically. Histologically, the mass was composed of large round to polyhedral neoplastic cells with marked cytological atypia. The neoplastic cells were often binucleated or multinucleated. Immunohistochemically, the neoplastic cells were intensely positive for Iba1 and vimentin, but fewer neoplastic cells expressed E-cadherin...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27860224/reduced-angiogenic-gene-expression-in-morbillivirus-triggered-oncolysis-in-a-translational-model-for-histiocytic-sarcoma
#9
Vanessa Maria Pfankuche, Ingo Spitzbarth, Stefanie Lapp, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcoma represents a rare malignant tumour with a short survival time, indicating the need of novel treatment strategies including oncolytic virotherapy. The underlying molecular mechanisms of viral oncolysis are largely unknown. As cancer in companion animals shares striking similarities with human counterparts, we chose a permanent canine histiocytic sarcoma cell line (DH82 cells) to identify global transcriptome changes following infection with canine distemper virus (CDV), a paramyxovirus closely related to human measles virus...
November 17, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27856472/histiocytic-sarcoma-secondary-neoplasm-or-transdifferentiation-in-the-setting-of-b-acute-lymphoblastic-leukemia
#10
Beenu Thakral, Joseph D Khoury
No abstract text is available yet for this article.
November 17, 2016: Blood
https://www.readbyqxmd.com/read/27828780/primary-histiocytic-sarcoma-of-the-uterine-cervix-an-extremely-rare-entity
#11
Fariba Binesh, Mojgan Karimi Zarchi, Mohammad Reza Vahidfar, Zahra Kargar Hadgiabadi
OBJECTIVE: Histiocytic sarcoma (HS) is an extraordinary rare tumor and has an offensive clinical course. HS of the uterine cervix is a far uncommon tumor with just a few cases described so far. Here we presented a case of primary HS of the uterine cervix in a 62-yearold female initially misdiagnosed as large cell non-keratinizing squamous cell carcinoma. To the best of our knowledge, this is the first reported case of HS of the uterine cervix from Iran. CASE REPORT: The patient presented with post-menopausal vaginal bleeding...
November 8, 2016: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/27823979/high-frequency-of-clonal-ig-and-t-cell-receptor-gene-rearrangements-in-histiocytic-and-dendritic-cell-neoplasms
#12
Wenting Huang, Tian Qiu, Linshu Zeng, Bo Zheng, Jianming Ying, Xiaoli Feng
The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27821709/proceedings-of-the-2016-national-toxicology-program-satellite-symposium
#13
Susan A Elmore, Vivian S Chen, Schantel Hayes-Bouknight, Jessica S Hoane, Kyathanahalli Janardhan, Linda H Kooistra, Thomas Nolte, Kathleen A Szabo, Gabrielle A Willson, Jeffrey C Wolf, David E Malarkey
The 2016 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in San Diego, CA, at the Society of Toxicologic Pathology's (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma, and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria collaborations...
January 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/27795864/histiocytic-sarcoma-in-a-kidney-transplant-patient-a-case-report-and-review-of-the-literature
#14
Maressa Pollen, Siraj El Jamal, Jack Lewin, Varsha Manucha
Objective. Histiocytic sarcoma (HS) is an aggressive neoplasm with only limited number of reported series of cases and rare case reports of occurrence as a posttransplant neoplastic disorder. The etiology and pathogenesis of the disease is unknown and the optimal treatment is still under investigation. We describe an unusual case of HS in a patient with a remote history of kidney transplant. Method and Results. A 54-year-old male with a remote history of renal transplantation under maintenance immunosuppression presented with features of sepsis...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27775241/cytological-features-of-inflammatory-pseudotumor-like-follicular-dendritic-cell-sarcoma-of-spleen-a-case-report
#15
Jen-Fan Hang, Lei-Chi Wang, Chiung-Ru Lai
Here, we present the first cytological report of a primary splenic inflammatory pseudotumor-like follicular dendritic cell sarcoma. The 57 year-old male was incidentally found with a 2.2 cm well-demarcated splenic nodule. A sonography guided fine needle aspiration of the lesion was performed. The cytologic smears revealed loosely cohesive fragments of oval to spindle cells in a background of prominent lymphoplasmacytic infiltration. The cells showed sparse chromatin, distinct nucleoli, syncytial cell borders, and occasional cytoplasmic processes...
October 24, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27720131/disseminated-histiocytic-sarcoma-in-an-african-hedgehog-atelerix-albiventris
#16
K Ogihara, T Itoh, Y Mizuno, K Tamukai, H Madarame
Disseminated histiocytic sarcoma (HS) was diagnosed on post-mortem examination of a 1.5-year-old African hedgehog (Atelerix albiventris) that was presented in poor physical condition and with diarrhoea. Leucocytosis and a hypoechoic abdominal mass were noted on haematological and ultrasonographical examinations. Gross pathological, histopathological, immunohistochemical and ultrastructural evaluation of the mass supported a diagnosis of disseminated HS. To our knowledge, this report represents the first documentation of disseminated HS in this species...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27639374/comprehensive-genomic-characterization-of-five-canine-lymphoid-tumor-cell-lines
#17
Sarah C Roode, Daniel Rotroff, Kristy L Richards, Peter Moore, Alison Motsinger-Reif, Yasuhiko Okamura, Takuya Mizuno, Hajime Tsujimoto, Steven E Suter, Matthew Breen
BACKGROUND: Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the primary tumors from which they were derived, appropriate characterization including cytogenetic and transcriptional assessment is crucial for assessing their clinical predictive value. RESULTS: In the following study, five canine LL cell lines, CLBL-1, Ema, TL-1 (Nody-1), UL-1, and 3132, were characterized using extensive immunophenotyping, karyotypic analysis, oligonucleotide array comparative genomic hybridization (oaCGH), and gene expression profiling...
September 17, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27594909/an-extremely-rare-case-of-a-high-grade-pleomorphic-cardiac-sarcoma-and-likely-cerebral-metastasis-in-a-young-patient
#18
T G Wilson, P Jenkins, A Hoschtitzky, M McCabe
To date, there have been less than a 100 confirmed case reports of primary cardiac malignant fibrous histiocytomas, a rare form of sarcoma. In this report, we discuss the case of a 15-year-old girl who initially presented with a histiocytic cerebral sarcoma that was treated with aggressive resection and chemotherapy. Three years later, the same patient developed increasing shortness of breath and was found to have a high-grade pleomorphic undifferentiated cardiac sarcoma that likely represents the primary tumour from which the cerebral lesion metastasised...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27587965/hepatic-involvement-of-histiocytic-sarcoma-ct-and-mri-findings
#19
Takatoshi Kubo, Shigeru Kiryu, Hiroyuki Akai, Yasunori Ota, Arinobu Tojo, Hideo Yoshida, Naoya Kato, Yoshiyasu Nakano, Kuni Ohtomo
Histiocytic sarcoma in the liver is an extremely rare hematological malignancy. Herein, we reported the case of a 68-year-old woman who presented with characteristic wedge-shaped abnormality bounded by hepatic veins on computed tomography and magnetic resonance imaging of the liver. In the wedge-shaped area, decreased portal flow and the deposition of iron were observed. These imaging findings are consistent with intrasinusoidal tumor cell infiltration. A liver biopsy was performed, and histiocytic sarcoma was confirmed histopathologically...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27585244/alternative-lengthening-of-telomeres-does-exist-in-various-canine-sarcomas
#20
Theresa Kreilmeier, Sandra Sampl, Abigail J Deloria, Ingrid Walter, Martin Reifinger, Marlene Hauck, Luke B Borst, Klaus Holzmann, Miriam Kleiter
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism (TMM) found in some human tumors such as sarcomas. Canine tumors are not characterized for ALT and the study aim was to identify if the ALT phenotype exists in canine sarcomas. Sixty-four canine sarcoma samples (20 snap-frozen, 44 FFPE) as well as six canine sarcoma cell lines were screened for ALT by C-circle assay. ALT was further evaluated by measuring telomere length via qPCR and telomere restriction-fragments including pulsed-field electrophoresis...
March 2017: Molecular Carcinogenesis
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