Xin Yin, Binxiao Su, Haopeng Zhang, Wenying Song, Hao Wu, Xiaomei Chen, Xijing Zhang, Hailong Dong, Lize Xiong
The aim of this study is to examine the role of one of the two-pore (2P) domain K(+) channels, TREK (TWIK-related K(+) channels, TREK)-1, mediated neuroprotection on spinal cord afforded by isoflurane preconditioning. In Experiment 1, male Sprague-Dawley rats were randomly assigned to control (Con) group, an isoflurane preconditioning (Iso) group, and sham group. Twenty-four hours after the last pretreatment, spinal cord ischemia was induced in Con and Iso groups. Neurobehavioral testing and histopathologic examination were performed after reperfusion...
May 2, 2012: Neuroscience Letters